|
Name |
Accession |
Description |
Interval |
E-value |
| PRK05826 |
PRK05826 |
pyruvate kinase; Provisional |
1-456 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235619 [Multi-domain] Cd Length: 465 Bit Score: 627.95 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 1 MLLKQTKIVATISDQRCDVDFIKQLFDAGMNVVRMNTAHLGREGAEKLINNVRSVSNR----IAILMDTKGPEVRTTVLA 76
Cdd:PRK05826 1 RMLRRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKlgrpVAILLDLKGPKIRVGKFK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 77 E-PIPFKAGDRVKVVGNPEQETTRECISVSYPHFVKDLNVDGHILIDDGDLELVVVEKTPDYLLCEVQNEATLGSRKSVN 155
Cdd:PRK05826 81 EgKITLKTGDKFTLDTDQKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGIN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 156 VPGVRINLPSLTEKDRTNILYAIEKNIDFIAHSFVRNKQDILDIKAILDAHNS-DIRIVAKIENQEGVDNIDEILEVADG 234
Cdd:PRK05826 161 IPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCpHAKIIAKIERAEAVDNIDEIIEASDG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 235 VMIARGDLGIEVPQERIPGIQRVLIRKCILAKKPVIVATQMLHTMISNPRPTRAEVTDIANAIYYRTDALMLSGETAYGK 314
Cdd:PRK05826 241 IMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAGK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 315 YPVEAVKTMTKIAAQAEKDkLSDNDIRIPLDENSNDVTAFLAKQAVKATTKLK-IRAIITDSYSGRTARNLAAFRGKYPV 393
Cdd:PRK05826 321 YPVEAVEAMARICKGAEKE-FSINLSKHRLDRQFDRIDEAIAMSAMYAANHLKgVKAIVALTESGRTARLISRFRPGAPI 399
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 496328440 394 LAICYKEKTMRHLALSYGVEAIYMPELANGQEYYFAALRRLLKEGRLCPTDMVGYLSSGKAGT 456
Cdd:PRK05826 400 FAVTRDEKTQRRLALYRGVYPVLFDSAADTDDAAEEALRLLLEKGLVESGDLVVVTSGDPMGT 462
|
|
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
3-466 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 623.59 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 3 LKQTKIVATISDQRCDVDFIKQLFDAGMNVVRMNTAHLGREGAEKLINNVRSVSNR----IAILMDTKGPEVRTTVLAE- 77
Cdd:COG0469 2 MRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKElgrpVAILLDLQGPKIRTGKFKEg 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 78 PIPFKAGDRVKVVGNPEqETTRECISVSYPHFVKDLNVDGHILIDDGDLELVVVEKTPDYLLCEVQNEATLGSRKSVNVP 157
Cdd:COG0469 82 PVELKKGDTFTLTTDDV-EGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNLP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 158 GVRINLPSLTEKDRTNILYAIEKNIDFIAHSFVRNKQDILDIKAILDAHNSDIRIVAKIENQEGVDNIDEILEVADGVMI 237
Cdd:COG0469 161 GVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDEIIEASDGIMV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 238 ARGDLGIEVPQERIPGIQRVLIRKCILAKKPVIVATQMLHTMISNPRPTRAEVTDIANAIYYRTDALMLSGETAYGKYPV 317
Cdd:COG0469 241 ARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYPV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 318 EAVKTMTKIAAQAEKDKLSDNDIRIPLDENSNDVTAFLAKQAVKATTKLKIRAIITDSYSGRTARNLAAFRGKYPVLAIC 397
Cdd:COG0469 321 EAVETMARIAEEAEKSLDYRRILDRLRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILALT 400
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 496328440 398 YKEKTMRHLALSYGVEAIYMPELANGQEYYFAALRRLLKEGRLCPTDMVGYLSS---GKAGTrTSFLEINVV 466
Cdd:COG0469 401 PNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGvpvGVPGT-TNTLKVHRV 471
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
4-440 |
1.05e-175 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 501.81 E-value: 1.05e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 4 KQTKIVATISDQRCDVDFIKQLFDAGMNVVRMNTAHLGREGAEKLINNVRSVS----NRIAILMDTKGPEVRT-TVLAEP 78
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAeklgRPVAILLDTKGPEIRTgEIKGGE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 79 IPFKAGDRVKVVGNP-EQETTRECISVSYPHFVKDLNVDGHILIDDGDLELVVVEKTPDYLLCEVQNEATLGSRKSVNVP 157
Cdd:TIGR01064 81 VKLKKGDKVIITTDDiKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 158 GVRINLPSLTEKDRTNILYAIEKNIDFIAHSFVRNKQDILDIKAILDAHN-SDIRIVAKIENQEGVDNIDEILEVADGVM 236
Cdd:TIGR01064 161 GADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDNIDEIAEASDGIM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 237 IARGDLGIEVPQERIPGIQRVLIRKCILAKKPVIVATQMLHTMISNPRPTRAEVTDIANAIYYRTDALMLSGETAYGKYP 316
Cdd:TIGR01064 241 VARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKYP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 317 VEAVKTMTKIAAQAEK--DKLSDNDIRIPLDENSNDVTAFLAKQAVKATTKLKIRAIITDSYSGRTARNLAAFRGKYPVL 394
Cdd:TIGR01064 321 VEAVQMMAKIAKEAEKalAYLTNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAPII 400
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 496328440 395 AICYKEKTMRHLALSYGVEAIYMPELAN-GQEYYFAALRRLLKEGRL 440
Cdd:TIGR01064 401 AVTPNERVARQLALYWGVFPFLVDEEPSdTDARVNKALELLKEKGIV 447
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
3-466 |
3.15e-161 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 465.25 E-value: 3.15e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 3 LKQTKIVATISDQRCDVDFIKQLFDAGMNVVRMNTAHLGREGAEKLINNVRSVSNR----IAILMDTKGPEVRTTVLAE- 77
Cdd:cd00288 1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKtggpVAIALDTKGPEIRTGLFKGg 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 78 -PIPFKAGDRVKVVGNP-EQETTRECISVSYPHFVKDLNVDGHILIDDGDLELVVVEKTPDY-LLCEVQNEATLGSRKSV 154
Cdd:cd00288 81 kDISLKAGDKFLVTTDPaAKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKtLVCEVLNGGVLGSRKGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 155 NVPGVRINLPSLTEKDRTNILYAIEKNIDFIAHSFVRNKQDILDIKAILDAHNSDIRIVAKIENQEGVDNIDEILEVADG 234
Cdd:cd00288 161 NLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILEASDG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 235 VMIARGDLGIEVPQERIPGIQRVLIRKCILAKKPVIVATQMLHTMISNPRPTRAEVTDIANAIYYRTDALMLSGETAYGK 314
Cdd:cd00288 241 IMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 315 YPVEAVKTMTKIAAQAEKdKLSDNDIRIPLD---ENSNDVTAFLAKQAVKATTKLKIRAIITDSYSGRTARNLAAFRGKY 391
Cdd:cd00288 321 YPVEAVKAMARICLEAEK-ALSHRVLFNEMRrltPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNA 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 392 PVLAICYKEKTMRHLALSYGVEAIYMPE----LANGQEYYF-AALRRLLKEGRLCPTDMVGYLSSGKAGT-RTSFLEINV 465
Cdd:cd00288 400 PIIAVTRNEQTARQLHLYRGVYPVLFEEpkpgWQEDTDARLkAAVNVAKEKGLLKKGDLVVVVQGWPVGSgSTNTMRILT 479
|
.
gi 496328440 466 V 466
Cdd:cd00288 480 V 480
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
3-332 |
3.44e-137 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 399.05 E-value: 3.44e-137
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 3 LKQTKIVATISDQRCDVDFIKQLFDAGMNVVRMNTAHLGREGAEKLINNVRSVSNR----IAILMDTKGPEVRTTVL--- 75
Cdd:pfam00224 1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKtggtVAIALDTKGPEIRTGNTkdg 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 76 AEPIPFKAGDRVKVVGNPE--QETTRECISVSYPHFVKDLNVDGHILIDDGDLELVVVEKTPD-YLLCEVQNEATLGSRK 152
Cdd:pfam00224 81 KKDIELKAGDEMIVSTDAKykGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDkTLVVEVLNGGVIGSRK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 153 SVNVPGVRINLPSLTEKDRTNILYAIEKNIDFIAHSFVRNKQDILDIKAILDAHNSDIRIVAKIENQEGVDNIDEILEVA 232
Cdd:pfam00224 161 GVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFDEILEAT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 233 DGVMIARGDLGIEVPQERIPGIQRVLIRKCILAKKPVIVATQMLHTMISNPRPTRAEVTDIANAIYYRTDALMLSGETAY 312
Cdd:pfam00224 241 DGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAK 320
|
330 340
....*....|....*....|
gi 496328440 313 GKYPVEAVKTMTKIAAQAEK 332
Cdd:pfam00224 321 GNYPVEAVRMMHEICLEAEK 340
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK05826 |
PRK05826 |
pyruvate kinase; Provisional |
1-456 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235619 [Multi-domain] Cd Length: 465 Bit Score: 627.95 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 1 MLLKQTKIVATISDQRCDVDFIKQLFDAGMNVVRMNTAHLGREGAEKLINNVRSVSNR----IAILMDTKGPEVRTTVLA 76
Cdd:PRK05826 1 RMLRRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKlgrpVAILLDLKGPKIRVGKFK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 77 E-PIPFKAGDRVKVVGNPEQETTRECISVSYPHFVKDLNVDGHILIDDGDLELVVVEKTPDYLLCEVQNEATLGSRKSVN 155
Cdd:PRK05826 81 EgKITLKTGDKFTLDTDQKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGIN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 156 VPGVRINLPSLTEKDRTNILYAIEKNIDFIAHSFVRNKQDILDIKAILDAHNS-DIRIVAKIENQEGVDNIDEILEVADG 234
Cdd:PRK05826 161 IPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCpHAKIIAKIERAEAVDNIDEIIEASDG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 235 VMIARGDLGIEVPQERIPGIQRVLIRKCILAKKPVIVATQMLHTMISNPRPTRAEVTDIANAIYYRTDALMLSGETAYGK 314
Cdd:PRK05826 241 IMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAGK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 315 YPVEAVKTMTKIAAQAEKDkLSDNDIRIPLDENSNDVTAFLAKQAVKATTKLK-IRAIITDSYSGRTARNLAAFRGKYPV 393
Cdd:PRK05826 321 YPVEAVEAMARICKGAEKE-FSINLSKHRLDRQFDRIDEAIAMSAMYAANHLKgVKAIVALTESGRTARLISRFRPGAPI 399
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 496328440 394 LAICYKEKTMRHLALSYGVEAIYMPELANGQEYYFAALRRLLKEGRLCPTDMVGYLSSGKAGT 456
Cdd:PRK05826 400 FAVTRDEKTQRRLALYRGVYPVLFDSAADTDDAAEEALRLLLEKGLVESGDLVVVTSGDPMGT 462
|
|
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
3-466 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 623.59 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 3 LKQTKIVATISDQRCDVDFIKQLFDAGMNVVRMNTAHLGREGAEKLINNVRSVSNR----IAILMDTKGPEVRTTVLAE- 77
Cdd:COG0469 2 MRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKElgrpVAILLDLQGPKIRTGKFKEg 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 78 PIPFKAGDRVKVVGNPEqETTRECISVSYPHFVKDLNVDGHILIDDGDLELVVVEKTPDYLLCEVQNEATLGSRKSVNVP 157
Cdd:COG0469 82 PVELKKGDTFTLTTDDV-EGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNLP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 158 GVRINLPSLTEKDRTNILYAIEKNIDFIAHSFVRNKQDILDIKAILDAHNSDIRIVAKIENQEGVDNIDEILEVADGVMI 237
Cdd:COG0469 161 GVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDEIIEASDGIMV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 238 ARGDLGIEVPQERIPGIQRVLIRKCILAKKPVIVATQMLHTMISNPRPTRAEVTDIANAIYYRTDALMLSGETAYGKYPV 317
Cdd:COG0469 241 ARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYPV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 318 EAVKTMTKIAAQAEKDKLSDNDIRIPLDENSNDVTAFLAKQAVKATTKLKIRAIITDSYSGRTARNLAAFRGKYPVLAIC 397
Cdd:COG0469 321 EAVETMARIAEEAEKSLDYRRILDRLRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILALT 400
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 496328440 398 YKEKTMRHLALSYGVEAIYMPELANGQEYYFAALRRLLKEGRLCPTDMVGYLSS---GKAGTrTSFLEINVV 466
Cdd:COG0469 401 PNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGvpvGVPGT-TNTLKVHRV 471
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
4-440 |
1.05e-175 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 501.81 E-value: 1.05e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 4 KQTKIVATISDQRCDVDFIKQLFDAGMNVVRMNTAHLGREGAEKLINNVRSVS----NRIAILMDTKGPEVRT-TVLAEP 78
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAeklgRPVAILLDTKGPEIRTgEIKGGE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 79 IPFKAGDRVKVVGNP-EQETTRECISVSYPHFVKDLNVDGHILIDDGDLELVVVEKTPDYLLCEVQNEATLGSRKSVNVP 157
Cdd:TIGR01064 81 VKLKKGDKVIITTDDiKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 158 GVRINLPSLTEKDRTNILYAIEKNIDFIAHSFVRNKQDILDIKAILDAHN-SDIRIVAKIENQEGVDNIDEILEVADGVM 236
Cdd:TIGR01064 161 GADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDNIDEIAEASDGIM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 237 IARGDLGIEVPQERIPGIQRVLIRKCILAKKPVIVATQMLHTMISNPRPTRAEVTDIANAIYYRTDALMLSGETAYGKYP 316
Cdd:TIGR01064 241 VARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKYP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 317 VEAVKTMTKIAAQAEK--DKLSDNDIRIPLDENSNDVTAFLAKQAVKATTKLKIRAIITDSYSGRTARNLAAFRGKYPVL 394
Cdd:TIGR01064 321 VEAVQMMAKIAKEAEKalAYLTNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAPII 400
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 496328440 395 AICYKEKTMRHLALSYGVEAIYMPELAN-GQEYYFAALRRLLKEGRL 440
Cdd:TIGR01064 401 AVTPNERVARQLALYWGVFPFLVDEEPSdTDARVNKALELLKEKGIV 447
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
3-466 |
3.15e-161 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 465.25 E-value: 3.15e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 3 LKQTKIVATISDQRCDVDFIKQLFDAGMNVVRMNTAHLGREGAEKLINNVRSVSNR----IAILMDTKGPEVRTTVLAE- 77
Cdd:cd00288 1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKtggpVAIALDTKGPEIRTGLFKGg 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 78 -PIPFKAGDRVKVVGNP-EQETTRECISVSYPHFVKDLNVDGHILIDDGDLELVVVEKTPDY-LLCEVQNEATLGSRKSV 154
Cdd:cd00288 81 kDISLKAGDKFLVTTDPaAKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKtLVCEVLNGGVLGSRKGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 155 NVPGVRINLPSLTEKDRTNILYAIEKNIDFIAHSFVRNKQDILDIKAILDAHNSDIRIVAKIENQEGVDNIDEILEVADG 234
Cdd:cd00288 161 NLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILEASDG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 235 VMIARGDLGIEVPQERIPGIQRVLIRKCILAKKPVIVATQMLHTMISNPRPTRAEVTDIANAIYYRTDALMLSGETAYGK 314
Cdd:cd00288 241 IMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 315 YPVEAVKTMTKIAAQAEKdKLSDNDIRIPLD---ENSNDVTAFLAKQAVKATTKLKIRAIITDSYSGRTARNLAAFRGKY 391
Cdd:cd00288 321 YPVEAVKAMARICLEAEK-ALSHRVLFNEMRrltPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNA 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 392 PVLAICYKEKTMRHLALSYGVEAIYMPE----LANGQEYYF-AALRRLLKEGRLCPTDMVGYLSSGKAGT-RTSFLEINV 465
Cdd:cd00288 400 PIIAVTRNEQTARQLHLYRGVYPVLFEEpkpgWQEDTDARLkAAVNVAKEKGLLKKGDLVVVVQGWPVGSgSTNTMRILT 479
|
.
gi 496328440 466 V 466
Cdd:cd00288 480 V 480
|
|
| PRK06354 |
PRK06354 |
pyruvate kinase; Provisional |
1-470 |
2.14e-148 |
|
pyruvate kinase; Provisional
Pssm-ID: 235784 [Multi-domain] Cd Length: 590 Bit Score: 436.28 E-value: 2.14e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 1 MLLKQTKIVATISDQRCDVDFIKQLFDAGMNVVRMNTAHLGREGAEKLINNVRSVSNR----IAILMDTKGPEVRTTVLA 76
Cdd:PRK06354 5 DLMRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKlgktVGILQDLQGPKIRLGRFE 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 77 E-PIPFKAGDRVkVVGNPEQETTRECISVSYPHFVKDLNVDGHILIDDGDLELVV--VEKTPDYLLCEVQNEATLGSRKS 153
Cdd:PRK06354 85 DgPIELKTGDEF-ILTSREVLGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVeeVDKADGELHCKVLVGGVLSNKKG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 154 VNVPGVRINLPSLTEKDRTNILYAIEKNIDFIAHSFVRNKQDILDIKAILDAHN-SDIRIVAKIENQEGVDNIDEILEVA 232
Cdd:PRK06354 164 VNFPGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHNgKHIPIIAKIEKQEAIDNIDAILELC 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 233 DGVMIARGDLGIEVPQERIPGIQRVLIRKCILAKKPVIVATQMLHTMISNPRPTRAEVTDIANAIYYRTDALMLSGETAY 312
Cdd:PRK06354 244 DGLMVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSNETAA 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 313 GKYPVEAVKTMTKIAAQAEKDkLSDNDIRIPLDENSNDVTAFLAkQAVKAT-TKLKIRAIITDSYSGRTARNLAAFRGKY 391
Cdd:PRK06354 324 GDYPVEAVQTMATIAVRIEKD-LPYRDILSKRPEFTTTITNAIS-QAVSHIaLQLDAAAIVTLTKSGATARNVSKYRPKT 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 392 PVLAICYKEKTMRHLALSYGVEAIYMPELANGQEYYFAALRRLLKEGRLCPTDMV----GYLsSGKAGTrTSFLEINVVE 467
Cdd:PRK06354 402 PILAVTPNESVARRLQLVWGVTPLLVLDAPSTDETFDAAINVAQESGLLKQGDLVvitaGTL-VGESGS-TDLMKVHVVG 479
|
...
gi 496328440 468 DAL 470
Cdd:PRK06354 480 AVV 482
|
|
| PRK09206 |
PRK09206 |
pyruvate kinase PykF; |
3-446 |
4.38e-143 |
|
pyruvate kinase PykF;
Pssm-ID: 181699 [Multi-domain] Cd Length: 470 Bit Score: 418.69 E-value: 4.38e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 3 LKQTKIVATISDQRCDVDFIKQLFDAGMNVVRMNTAHLGREGAEKLINNVRSVSN----RIAILMDTKGPEVRTTVLAE- 77
Cdd:PRK09206 1 MKKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSktgkKAAILLDTKGPEIRTMKLEGg 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 78 -PIPFKAGDRV------KVVGNPEqettreCISVSYPHFVKDLNVDGHILIDDGDLELVVVEKTPDYLLCEVQNEATLGS 150
Cdd:PRK09206 81 nDVSLKAGQTFtfttdkSVVGNKE------RVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGDLGE 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 151 RKSVNVPGVRINLPSLTEKDRTNILYAIEKNIDFIAHSFVRNKQDILDIKAILDAHN-SDIRIVAKIENQEGVDNIDEIL 229
Cdd:PRK09206 155 NKGVNLPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGgENIQIISKIENQEGLNNFDEIL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 230 EVADGVMIARGDLGIEVPQERIPGIQRVLIRKCILAKKPVIVATQMLHTMISNPRPTRAEVTDIANAIYYRTDALMLSGE 309
Cdd:PRK09206 235 EASDGIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGE 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 310 TAYGKYPVEAVKTMTKIAAQAekDKLSDNDIRIPLDENSNDVTAFLAKQAVKATTKLKIRAIITDSYSGRTARNLAAFRG 389
Cdd:PRK09206 315 SAKGKYPLEAVSIMATICERT--DRVMNSRLESNNDNRKLRITEAVCRGAVETAEKLDAPLIVVATQGGKSARSVRKYFP 392
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 496328440 390 KYPVLAICYKEKTMRHLALSYGVEAIYMPELANGQEYYFAALRRLLKEGRLCPTDMV 446
Cdd:PRK09206 393 DATILALTTNEKTARQLVLSKGVVPQLVKEIASTDDFYRLGKELALQSGLAQKGDVV 449
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
3-332 |
3.44e-137 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 399.05 E-value: 3.44e-137
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 3 LKQTKIVATISDQRCDVDFIKQLFDAGMNVVRMNTAHLGREGAEKLINNVRSVSNR----IAILMDTKGPEVRTTVL--- 75
Cdd:pfam00224 1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKtggtVAIALDTKGPEIRTGNTkdg 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 76 AEPIPFKAGDRVKVVGNPE--QETTRECISVSYPHFVKDLNVDGHILIDDGDLELVVVEKTPD-YLLCEVQNEATLGSRK 152
Cdd:pfam00224 81 KKDIELKAGDEMIVSTDAKykGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDkTLVVEVLNGGVIGSRK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 153 SVNVPGVRINLPSLTEKDRTNILYAIEKNIDFIAHSFVRNKQDILDIKAILDAHNSDIRIVAKIENQEGVDNIDEILEVA 232
Cdd:pfam00224 161 GVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFDEILEAT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 233 DGVMIARGDLGIEVPQERIPGIQRVLIRKCILAKKPVIVATQMLHTMISNPRPTRAEVTDIANAIYYRTDALMLSGETAY 312
Cdd:pfam00224 241 DGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAK 320
|
330 340
....*....|....*....|
gi 496328440 313 GKYPVEAVKTMTKIAAQAEK 332
Cdd:pfam00224 321 GNYPVEAVRMMHEICLEAEK 340
|
|
| PRK06247 |
PRK06247 |
pyruvate kinase; Provisional |
3-446 |
3.55e-124 |
|
pyruvate kinase; Provisional
Pssm-ID: 180487 [Multi-domain] Cd Length: 476 Bit Score: 370.41 E-value: 3.55e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 3 LKQTKIVATISDQRCDVDFIKQLFDAGMNVVRMNTAHLGREGAEKLINNVRSVSNR----IAILMDTKGPEVRTTVLAE- 77
Cdd:PRK06247 4 NRRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDEtgrpIGILADLQGPKLRLGRFADg 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 78 PIPFKAGDRVKVVGNPEQETTREcISVSYPHFVKDLNVDGHILIDDGDLELVVVEKTPDYLLCEVQNEATLGSRKSVNVP 157
Cdd:PRK06247 84 KVQLANGQTFRLDVDDAPGDHDR-VSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGGPVSDRKGVSLP 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 158 GVRINLPSLTEKDRTNILYAIEKNIDFIAHSFVRNKQDILDIKAILdahNSDIRIVAKIENQEGVDNIDEILEVADGVMI 237
Cdd:PRK06247 163 GTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKII---GGRVPVMAKIEKPQAIDRLEAIVEASDAIMV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 238 ARGDLGIEVPQERIPGIQRVLIRKCILAKKPVIVATQMLHTMISNPRPTRAEVTDIANAIYYRTDALMLSGETAYGKYPV 317
Cdd:PRK06247 240 ARGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETASGKYPV 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 318 EAVKTMTKIAAQAEKDKLSDNDI---RIPLDENSNDVTAFLAKQAVKattKLKIRAIITDSYSGRTARNLAAFRGKYPVL 394
Cdd:PRK06247 320 EAVRTMARIIRQVERDPTYPPLIhaqRPQPEATKRDAISYAARDIAE---RLDLAALVAYTSSGDTALRAARERPPLPIL 396
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 496328440 395 AICYKEKTMRHLALSYGVEAIYMPELANGQEYYFAALRRLLKEGRLCPTDMV 446
Cdd:PRK06247 397 ALTPNPETARRLALTWGVHCVVVDDARDTDDMVRRADRIALAEGFYKRGDRV 448
|
|
| PLN02461 |
PLN02461 |
Probable pyruvate kinase |
4-423 |
3.26e-121 |
|
Probable pyruvate kinase
Pssm-ID: 215255 [Multi-domain] Cd Length: 511 Bit Score: 364.30 E-value: 3.26e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 4 KQTKIVATISDQRCDVDFIKQLFDAGMNVVRMNTAHLGREGAEKLINNVRSVSN----RIAILMDTKGPEVRTTVLA--E 77
Cdd:PLN02461 21 PKTKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMAntgiLCAVMLDTKGPEIRTGFLKdgK 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 78 PIPFKAGDRVKVVGNPEQETTRECISVSYPHFVKDLNVDGHILIDDGDLELVVVEKTPDYLL--CEVQNEATLGSRKSVN 155
Cdd:PLN02461 101 PVQLKQGQEITITTDYSIKGDENMIAMSYKKLAVDVKPGSVILCADGTITLTVLSCDVEAGTvrCRCENSAMLGERKNVN 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 156 VPGVRINLPSLTEKDRTNIL-YAIEKNIDFIAHSFVRNKQDILDIKAILDAHNSDIRIVAKIENQEGVDNIDEILEVADG 234
Cdd:PLN02461 181 LPGVVVDLPTLTEKDKEDILqWGVPNKIDFIALSFVRKGSDLVEVRKVLGEHAKSILLISKVENQEGLDNFDDILAESDA 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 235 VMIARGDLGIEVPQERIPGIQRVLIRKCILAKKPVIVATQMLHTMISNPRPTRAEVTDIANAIYYRTDALMLSGETAYGK 314
Cdd:PLN02461 261 FMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGETAAGA 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 315 YPVEAVKTMTKIAAQAEK----DKLSDNDIR---IPLdensnDVTAFLAKQAVKATTKLKIRAIITDSYSGRTARNLAAF 387
Cdd:PLN02461 341 YPELAVKTMARICREAEAsldyGALFKEIMRsapLPM-----SPLESLASSAVRTANKVKASLIVVLTRGGTTARLVAKY 415
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 496328440 388 RGKYPVLAICYKEKTMRHLALSYGVEA------IY---MPELANG 423
Cdd:PLN02461 416 RPAVPILSVVVPEITTDSFDWSCSDEAparhslIYrglIPVLAEG 460
|
|
| PTZ00066 |
PTZ00066 |
pyruvate kinase; Provisional |
4-438 |
4.75e-121 |
|
pyruvate kinase; Provisional
Pssm-ID: 173361 [Multi-domain] Cd Length: 513 Bit Score: 363.70 E-value: 4.75e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 4 KQTKIVATISDQRCDVDFIKQLFDAGMNVVRMNTAHLGREGAEKLINNVRSV-----SNRIAILMDTKGPEVRTTVL--A 76
Cdd:PTZ00066 38 KKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVREAakarpNANLGILLDTKGPEIRTGFLknH 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 77 EPIPFKAGDRVKVVGNPEQETTRECISVSYPHFVKDLNVDGHILIDDGDLELVVVEKTPDYLLCEVQNEATLGSRKSVNV 156
Cdd:PTZ00066 118 KPITLKEGQTLKITTDYTFLGDETCISCSYKKLPQSVKVGNIILIADGSLSCKVLEVHDDYIITKVLNNATIGERKNMNL 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 157 PGVRINLPSLTEKDRTNIL-YAIEKNIDFIAHSFVRNKQDILDIKAILDAHNSDIRIVAKIENQEGVDNIDEILEVADGV 235
Cdd:PTZ00066 198 PGVKVELPVIGEKDKNDILnFAIPMGCDFIALSFVQSADDVRLCRQLLGERGRHIKIIPKIENIEGLINFDEILAESDGI 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 236 MIARGDLGIEVPQERIPGIQRVLIRKCILAKKPVIVATQMLHTMISNPRPTRAEVTDIANAIYYRTDALMLSGETAYGKY 315
Cdd:PTZ00066 278 MVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVMLSGETANGKF 357
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 316 PVEAVKTMTKIAAQAE---------KDKLSDNDIRIPLDENsndvtafLAKQAVKATTKLKIRAIITDSYSGRTARNLAA 386
Cdd:PTZ00066 358 PVEAVNIMAKICFEAEtcidyrvlyHAIHLAVPTPVSVQEA-------VARSAVETAEDINAKLIIALTETGNTARLISK 430
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 496328440 387 FRGKYPVLAICYKEKTMRHLALSYGVEAIYMPELANGQEYYFAAL-----RRLLKEG 438
Cdd:PTZ00066 431 YRPSCTILALSASPSVVKSLSVARGVTTYVVNSFQGTDVVIRNAIalakeRGLVESG 487
|
|
| PLN02623 |
PLN02623 |
pyruvate kinase |
4-453 |
1.34e-103 |
|
pyruvate kinase
Pssm-ID: 215334 [Multi-domain] Cd Length: 581 Bit Score: 321.11 E-value: 1.34e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 4 KQTKIVATISDQRCDVDFIKQLFDAGMNVVRMNTAHLGREGAEKLIN-----NVRSVSNRIAILMDTKGPEVRTTVLAEP 78
Cdd:PLN02623 110 RKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDlvkeyNAQSKDNVIAIMLDTKGPEVRSGDLPQP 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 79 IPFKAGDRV-----KVVGnpeqetTRECISVSYPHFVKDLNVDGHILIDDGDLELVVVEKTPDYLLCEVQNEATLGSRKS 153
Cdd:PLN02623 190 IMLEEGQEFtftikRGVS------TEDCVSVNYDDFVNDVEVGDMLLVDGGMMSLAVKSKTSDSVKCEVVDGGELKSRRH 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 154 VNVPGVRINLPSLTEKDRTNILYAIEKNIDFIAHSFVRNKQDILDIKAILDAHNSDIRIVAKIENQEGVDNIDEILEVAD 233
Cdd:PLN02623 264 LNVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSCNADIHVIVKIESADSIPNLHSIITASD 343
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 234 GVMIARGDLGIEVPQERIPGIQRVLIRKCILAKKPVIVATQMLHTMISNPRPTRAEVTDIANAIYYRTDALMLSGETAYG 313
Cdd:PLN02623 344 GAMVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHG 423
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 314 KYPVEAVKTMTKIAAQAEKdKLSDNDIRIPLDENS-NDVTAFLAKQAVKATTKLKIrAIITDSYSGRTARNLAAFRGKYP 392
Cdd:PLN02623 424 KFPLKAVKVMHTVALRTEA-TLPEGTTPPNLGQAFkNHMSEMFAFHATMMANTLGT-SIIVFTRTGFMAILLSHYRPSGT 501
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 496328440 393 VLAICYKEKTMRHLALSYGVEAIYMPELANGQEYYFAALRRLLKEGRLCPTDMVGYLSSGK 453
Cdd:PLN02623 502 IFAFTNEKRIQQRLALYQGVCPIYMQFSDDAEETFARALSLLLNKGMVKEGEEVALVQSGR 562
|
|
| PTZ00300 |
PTZ00300 |
pyruvate kinase; Provisional |
30-416 |
3.90e-103 |
|
pyruvate kinase; Provisional
Pssm-ID: 140321 [Multi-domain] Cd Length: 454 Bit Score: 315.84 E-value: 3.90e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 30 MNVVRMNTAHLGREGAEKLINNVRSVSNR----IAILMDTKGPEVRTTVLAE-PIPFKAGDRVKVVGNP--EQETTRECI 102
Cdd:PTZ00300 1 MSVARMNFSHGSHEYHQTTINNVRQAAAElgvnIAIALDTKGPEIRTGLFVGgEAVMERGATCYVTTDPafADKGTKDKF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 103 SVSYPHFVKDLNVDGHILIDDGDLELVVVEKTPDYLL-CEVQNEATLGSRKSVNVPGVRINLPSLTEKDRTNILYAIEKN 181
Cdd:PTZ00300 81 YIDYQNLSKVVRPGGYIYIDDGILILHVQSHEDEQTLkCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCADLQFGVEQG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 182 IDFIAHSFVRNKQDILDIKAILDAHNSDIRIVAKIENQEGVDNIDEILEVADGVMIARGDLGIEVPQERIPGIQRVLIRK 261
Cdd:PTZ00300 161 VDMIFASFIRSAEQVGEVRKALGAKGGDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKILISK 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 262 CILAKKPVIVATQMLHTMISNPRPTRAEVTDIANAIYYRTDALMLSGETAYGKYPVEAVKTMTKIAAQAE---KDKLSDN 338
Cdd:PTZ00300 241 CNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQsavNEYVFFN 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 339 DIR----IPLdensnDVTAFLAKQAVKATTKLKIRAIITDSYSGRTARNLAAFRGKYPVLAICYKEKTMRHLALSYGVEA 414
Cdd:PTZ00300 321 SIKklqpIPM-----SAEEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVES 395
|
..
gi 496328440 415 IY 416
Cdd:PTZ00300 396 VF 397
|
|
| PRK06739 |
PRK06739 |
pyruvate kinase; Validated |
9-331 |
2.69e-85 |
|
pyruvate kinase; Validated
Pssm-ID: 180676 [Multi-domain] Cd Length: 352 Bit Score: 266.43 E-value: 2.69e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 9 VATISDQRCDVDFIKQLFDAGMNVVRMNTAHLGREGAEKLINNVRSVSNRIAILMDTKGPEVRTTVL-AEPIPFKAGDRV 87
Cdd:PRK06739 6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVKSLDDSIKILGDVQGPKIRLGEIkGEQITLQAGDSF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 88 KVVGNPEQETTRECiSVSYPHFVKDLNVDGHILIDDGDLELVVVEKTPDYLLCEVQNEATLGSRKSVNVPGVRINLPSLT 167
Cdd:PRK06739 86 ILHTQPVTGSSTEA-SVDYEGIANDVKVGSRILMNDGEVELIVEKVSTDKIETKVKTGGNISSHKGVNLPGAIVRLPAIT 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 168 EKDRTNILYAIEKNIDFIAHSFVRNKQDILDIKA-ILDAHNSDIRIVAKIENQEGVDNIDEILEVADGVMIARGDLGIEV 246
Cdd:PRK06739 165 EKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDfIQQYKETSPNLIAKIETMEAIENFQDICKEADGIMIARGDLGVEL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 247 PQERIPGIQRVLIRKCILAKKPVIVATQMLHTMISNPRPTRAEVTDIANAIYYRTDALMLSGETAYGKYPVEAVKTMTKI 326
Cdd:PRK06739 245 PYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESASGEHPIESVSTLRLV 324
|
....*
gi 496328440 327 AAQAE 331
Cdd:PRK06739 325 SEFAE 329
|
|
| PLN02765 |
PLN02765 |
pyruvate kinase |
6-402 |
1.41e-83 |
|
pyruvate kinase
Pssm-ID: 215409 [Multi-domain] Cd Length: 526 Bit Score: 267.31 E-value: 1.41e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 6 TKIVATISDQRCDVDFIKQLFDAGMNVVRMNTAHLGREGAEKLINN----VRSVSNRIAILMDTKGPEVRTTVLAE-PIP 80
Cdd:PLN02765 30 TKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENlkiaVKNTKKLCAVMLDTVGPELQVINKTEkPIS 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 81 FKAGDRVKVVGNPEQETTRECISVSYPHFVKDLNVDGHILI--------DDGDLELVVVEKTPDYLLCEVQNEATL-GSR 151
Cdd:PLN02765 110 LKAGNTVTLTPDQSKEASSEVLPINFPGLAKAVKPGDTIFVgqylftgsETTSVWLEVDEVKGDDVVCTVKNSATLaGSL 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 152 KSVNVPGVRINLPSLTEKDRTNI-LYAIEKNIDFIAHSFVRNKQDILDIKAILDAHN-SDIRIVAKIENQEGVDNIDEIL 229
Cdd:PLN02765 190 FTLHVSQVRIDLPTLSEKDKEVIsTWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGlSQTQIFAKIENVEGLTHFDEIL 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 230 EVADGVMIARGDLGIEVPQERIPGIQRVLIRKCILAKKPVIVaTQMLHTMISNPRPTRAEVTDIANAIYYRTDALMLSGE 309
Cdd:PLN02765 270 QEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDVANAVLDGADAILLGAE 348
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 310 TAYGKYPVEAVKTMTKIAAQAEKdkLSDNDIRI-----PLDENSNDVTAfLAKQAVKATTKLKIRAIITDSYSGRTARNL 384
Cdd:PLN02765 349 TLRGLYPVETISTVGRICAEAEK--VFNQDLYFkktvkYVGEPMSHLES-IASSAVRAAIKVKASVIIVFTSSGRAARLI 425
|
410
....*....|....*....
gi 496328440 385 AAFRGKYPVLA-ICYKEKT 402
Cdd:PLN02765 426 AKYRPTMPVLSvVIPRLKT 444
|
|
| PLN02762 |
PLN02762 |
pyruvate kinase complex alpha subunit |
3-412 |
9.94e-77 |
|
pyruvate kinase complex alpha subunit
Pssm-ID: 215407 [Multi-domain] Cd Length: 509 Bit Score: 249.28 E-value: 9.94e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 3 LKQTKIVATISDQRCDVDFIKQLFDAGMNVVRMNTAHLGREGAEKLINNVRSVSNR----IAILMDTKGPEVRTTVLAEP 78
Cdd:PLN02762 24 TRRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRLNEEkgfaVAVMMDTEGSEIHMGDLGGA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 79 IPFKAGD------RVKVVGNPEQETTrecISVSYPHFVKDLNVDGHILIDDGDLELVVVEKTPDYLLCEVQNEATLGSRK 152
Cdd:PLN02762 104 SSAKAEDgeewtfTVRKFDGSRPEFT---IQVNYDGFAEDVKVGDELVVDGGMVRFEVIEKIGPDVKCKCTDPGLLLPRA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 153 SVN-------VPGVRINLPSLTEKDRTNILYAIEKNIDFIAHSFVRNKQDILDIKAILDAH--NSDIRIVAKIENQEGVD 223
Cdd:PLN02762 181 NLTfwrdgslVRERNAMLPTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAARsrDSDIGVIAKIESLDSLK 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 224 NIDEILEVADGVMIARGDLGIEVPQERIPGIQRVLIRKCILAKKPVIVATQMLHTMISNPRPTRAEVTDIANAIYYRTDA 303
Cdd:PLN02762 261 NLEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQRADA 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 304 LMLSGETAYGKYPVEAVKTMTKIAAQAEK--------DKLSDNDIRIPLdenSNDVTAFLAKQAVKATTKLKIRAIITDS 375
Cdd:PLN02762 341 LMLSGESAMGLYPEKALSVLRSVSLRMELwsreekrhEALELPQLSSSL---SDRISEEICNSAAKMANNLGVDAIFVYT 417
|
410 420 430
....*....|....*....|....*....|....*..
gi 496328440 376 YSGRTARNLAAFRGKYPVLAICYKEKTMRHLALSYGV 412
Cdd:PLN02762 418 KHGHMASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGL 454
|
|
| PRK08187 |
PRK08187 |
pyruvate kinase; Validated |
4-320 |
3.38e-61 |
|
pyruvate kinase; Validated
Pssm-ID: 236178 Cd Length: 493 Bit Score: 207.95 E-value: 3.38e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 4 KQTKIVATI-SDQRCDVDFIKQLFDAGMNVVRMNTAHLGREGAEKLINNVR----SVSNRIAILMDTKGPEVRTTVLAEP 78
Cdd:PRK08187 133 RRTRIMVTLpSEAADDPDFVLRLAERGMDCARINCAHDDPAAWQAMIGHLRqaerATGRRCKILMDLAGPKIRTGAVAGP 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 79 IP---FKAGDRVKVVGNPEQETTREC---ISVSYPHFVKDLNVDGHILIDDGDLELVVVEKTPDYLLCEVQNEATLGSR- 151
Cdd:PRK08187 213 LGktrLYTGDRLALVAQGPPRRIDEEhfqVTCTLPEILARLAVGARVWIDDGKLGARVERVGPGGALLEVTHARPKGLKl 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 152 ---KSVNVPGVRINLPSLTEKDRTNILYAIEkNIDFIAHSFVRNKQDILDIKAILDAHNSDIR----IVAKIENQEGVDN 224
Cdd:PRK08187 293 kpeKGLNFPDTALDLPALTEKDRADLDFVAR-HADLVGYSFVQSPGDVEALQAALAARRPDDWrklgLVLKIETPRAVAN 371
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 225 IDEILEVADG-----VMIARGDLGIEVPQERIPGIQRVLIRKCILAKKPVIVATQMLHTMISNPRPTRAEVTDIANAiyY 299
Cdd:PRK08187 372 LPELIVQAAGrqpfgVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSRAEMTDAAMA--A 449
|
330 340
....*....|....*....|.
gi 496328440 300 RTDALMLSGetayGKYPVEAV 320
Cdd:PRK08187 450 RAECVMLNK----GPYLVEAV 466
|
|
| PykA2 |
COG3848 |
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms]; |
261-470 |
1.31e-41 |
|
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
Pssm-ID: 443058 Cd Length: 321 Bit Score: 150.82 E-value: 1.31e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 261 KCILAKKPVIVATQMLHTMISNPRPTRAEVTDIANAIYYRTDALMLSGETAYGKYPVEAVKTMTKIAAQAEKDKLSDNDI 340
Cdd:COG3848 1 KCNAAGKPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEDLEYREQR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 341 RIPLDENSNDVTAFLAKQAVKATTKLKIRAIITDSYSGRTARNLAAFRGKYPVLAICYKEKTMRHLALSYGVEAIYMPEL 420
Cdd:COG3848 81 VPRAKESSTTITDAISHAVATTAADLGAAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGVYPLLVEES 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 496328440 421 ANGQEYYFAALRRLLKEGRLCPTDMV----GYLsSGKAGTrTSFLEINVVEDAL 470
Cdd:COG3848 161 ASTDEMFAVAVALALEAGLVKDGDLVvitaGVP-VGVSGT-TNLLKVHVVGDVL 212
|
|
| PRK14725 |
PRK14725 |
pyruvate kinase; Provisional |
18-326 |
2.52e-41 |
|
pyruvate kinase; Provisional
Pssm-ID: 237804 Cd Length: 608 Bit Score: 155.88 E-value: 2.52e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 18 DVDFIKQLFDAGMNVVRMNTAHLGREGAEKLINNVRSVSNR----IAILMDTKGPEVRT--------------------T 73
Cdd:PRK14725 154 DPDLVRRLLAAGMDIARINCAHDDPEAWRAMIANVRTAEEElgrrCRIAMDLAGPKLRTgpiapgprviklrptrdalgR 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 74 VLA------------EPIP----------------FKAGDRV------------KVVGN--------------------- 92
Cdd:PRK14725 234 VLTparlwltasespPPSPppgpvglpvdpewlarLEPGDELrftdargkkrklTVTEVddegvlaegsqtaylangtll 313
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 93 -------------PEQET------------TREC--------------ISVSYPHFVKDLNVDGHILIDDGDLELVVVEK 133
Cdd:PRK14725 314 rlgrhdstrvgglPPVEQklrlkvgdrlvlTRDDapgdpaqgdapparISCTLPEAFRAARVGERVWFDDGKIGAVVVKV 393
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 134 TPDYLLCEVQNEATLGSR----KSVNVPGVRINLPSLTEKDRTNiLYAIEKNIDFIAHSFVRNKQDILDIKAILDAHN-S 208
Cdd:PRK14725 394 EADEVELRITHARPGGSKlkagKGINLPDSHLPLPALTDKDLED-LAFVAKHADIVALSFVRSPEDVRLLLDALEKLGaD 472
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 209 DIRIVAKIENQEGVDNIDEILEVA-----DGVMIARGDLGIEVPQERIPGIQRVLIRKCILAKKPVIVATQMLHTMISNP 283
Cdd:PRK14725 473 DLGVVLKIETRRAFENLPRILLEAmrhprFGVMIARGDLAVEVGFERLAEVQEEILWLCEAAHVPVIWATQVLESLAKKG 552
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 496328440 284 RPTRAEVTDIANAIyyRTDALMLSGetayGKYPVEAVKTMTKI 326
Cdd:PRK14725 553 LPSRAEITDAAMAL--RAECVMLNK----GPHIVEAVRVLDDI 589
|
|
| PK_C |
pfam02887 |
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ... |
355-446 |
5.41e-16 |
|
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.
Pssm-ID: 460738 [Multi-domain] Cd Length: 114 Bit Score: 73.67 E-value: 5.41e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 355 LAKQAVKATTKLKIRAIITDSYSGRTARNLAAFRGKYPVLAICYKEKTMRHLALSYGVEAIYMPELANGQEYYFAALRRL 434
Cdd:pfam02887 3 IAHAAVEAAEELGAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDEAETTDEMLRRAVKVA 82
|
90
....*....|..
gi 496328440 435 LKEGRLCPTDMV 446
Cdd:pfam02887 83 KEAGLVKKGDLV 94
|
|
| HpcH_HpaI |
pfam03328 |
HpcH/HpaI aldolase/citrate lyase family; This family includes 2,4-dihydroxyhept-2-ene-1, ... |
157-293 |
1.93e-04 |
|
HpcH/HpaI aldolase/citrate lyase family; This family includes 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase and 4-hydroxy-2-oxovalerate aldolase.
Pssm-ID: 427247 [Multi-domain] Cd Length: 221 Bit Score: 42.73 E-value: 1.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496328440 157 PGVRINL--PSLTEKDrtniLYAIEKNIDFIAHSFVRNKQDILDIKAILDAH-------NSDIRIVAKIENQEGVDNIDE 227
Cdd:pfam03328 62 VVVRVNSldSPFGKQD----LAVLDLGAQVVLVPKVETAEDARAAVSAIRYPpkgirraNGNTCLLAQIESALGVLNADE 137
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 496328440 228 ILEV--ADGVMIARGDLGIEVPQERIPGIQRVL-IRKCIL--AKKPVIVATQMLHTMISNPRPTRAEVTDI 293
Cdd:pfam03328 138 IAAVegVDGIFLGAEDLSADLGTLRSPGGPEVLyARERIVtaARAAGIAAFDTVYSDENDAEGFLAEGALF 208
|
|
| PRK10558 |
PRK10558 |
alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional |
207-242 |
9.66e-04 |
|
alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional
Pssm-ID: 182547 Cd Length: 256 Bit Score: 40.88 E-value: 9.66e-04
10 20 30
....*....|....*....|....*....|....*...
gi 496328440 207 NSDIRIVAKIENQEGVDNIDEI--LEVADGVMIARGDL 242
Cdd:PRK10558 143 NKNITVLVQIESQQGVDNVDAIaaTEGVDGIFVGPSDL 180
|
|
| |
