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Conserved domains on  [gi|496082244|ref|WP_008806751|]
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MULTISPECIES: putative transporter [Klebsiella]

Protein Classification

Yide family putative transporter( domain architecture ID 11480057)

putative transporter similar to Escherichia coli protein YidE

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK03818 PRK03818
putative transporter; Validated
1-552 0e+00

putative transporter; Validated


:

Pssm-ID: 179654 [Multi-domain]  Cd Length: 552  Bit Score: 955.47  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244   1 MSEIALTVSVLALVAVVGLWIGNVKIRGVGFGIGGVLFGGIIVGHFVDQAGVALSSPMLHFIQEFGLILFVYTIGIQVGP 80
Cdd:PRK03818   1 MSDIALTVSILALVAVVGLWIGNIKIRGVGLGIGGVLFGGIIVGHFVSQFGLTLDSDMLHFIQEFGLILFVYTIGIQVGP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244  81 GFFASLRVSGLRLNLFAILIVILGGLVTAVLHKLFNIPLPVVLGIFSGAVTNTPALGAGQQILRDLGVPFEVVDQMGMSY 160
Cdd:PRK03818  81 GFFSSLRKSGLRLNLFAVLIVILGGLVTAILHKLFGIPLPVMLGIFSGAVTNTPALGAGQQILRDLGTPGDLVDQMGMGY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244 161 AMAYPFGICGILLTMWLVRLFFRINVEKEAQRFEESSGNGHANLHTINVRVENPNLNQMAIQDVPMLNSDNIVCSRLKRG 240
Cdd:PRK03818 161 AMAYPFGICGILLSMWLIRLIFRINVDKEAQEFESSSGNGHELLQTINIRVENPNLHGKAIKDVPILNGDKFVCSRLKRG 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244 241 ELLMVPAPGTLIQAGDLLHLVGRPEDLHNAQLVIGQEVATSLSTRGTDLKVERVVVTNEKVLGKKIRDLHVKQRYDVVIS 320
Cdd:PRK03818 241 DTLMVPSPDTIIQLGDLLHLVGQPEDLHKAQLVIGEEVDTSLSTRGTDLRSERVVVTNEKVLGKKLRDLHLKNKYGVVIS 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244 321 RLNRAGVELVASSSASLQFGDILNLVGRQEAIDAVAAELGNAQQKLQQVQMLPVFIGIGLGVLLGSIPLFIPGFPAALKL 400
Cdd:PRK03818 321 RLNRAGVELVASPDLSLQFGDILNLVGRPEAIDAVANVLGNAQQKLQQVQMLPVFIGIGLGVLLGSIPFFIPGFPAALKL 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244 401 GLAGGPLIMALILGRIGSIGKLYWFMPPSANLALRELGIVLFLAVVGLKSGGDFVATLTQGEGLSWIAYGIFITAIPLLT 480
Cdd:PRK03818 401 GLAGGPLIVALILGRIGSIGKLYWFMPPSANLALRELGIVLFLAVVGLKSGGDFVDTLVNGEGLSWIGYGFLITAVPLLI 480
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 496082244 481 VGILARMLAKMNYLTLCGMLAGSMTDPPALAFANNLHATSGAAALSYATVYPLVMFLRIITPQLLAVLFWGL 552
Cdd:PRK03818 481 VGILARMLAKMNYLTLCGMLAGSMTDPPALAFANNLHPTSGAAALSYATVYPLVMFLRIITPQLLAVLFWSL 552
 
Name Accession Description Interval E-value
PRK03818 PRK03818
putative transporter; Validated
1-552 0e+00

putative transporter; Validated


Pssm-ID: 179654 [Multi-domain]  Cd Length: 552  Bit Score: 955.47  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244   1 MSEIALTVSVLALVAVVGLWIGNVKIRGVGFGIGGVLFGGIIVGHFVDQAGVALSSPMLHFIQEFGLILFVYTIGIQVGP 80
Cdd:PRK03818   1 MSDIALTVSILALVAVVGLWIGNIKIRGVGLGIGGVLFGGIIVGHFVSQFGLTLDSDMLHFIQEFGLILFVYTIGIQVGP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244  81 GFFASLRVSGLRLNLFAILIVILGGLVTAVLHKLFNIPLPVVLGIFSGAVTNTPALGAGQQILRDLGVPFEVVDQMGMSY 160
Cdd:PRK03818  81 GFFSSLRKSGLRLNLFAVLIVILGGLVTAILHKLFGIPLPVMLGIFSGAVTNTPALGAGQQILRDLGTPGDLVDQMGMGY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244 161 AMAYPFGICGILLTMWLVRLFFRINVEKEAQRFEESSGNGHANLHTINVRVENPNLNQMAIQDVPMLNSDNIVCSRLKRG 240
Cdd:PRK03818 161 AMAYPFGICGILLSMWLIRLIFRINVDKEAQEFESSSGNGHELLQTINIRVENPNLHGKAIKDVPILNGDKFVCSRLKRG 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244 241 ELLMVPAPGTLIQAGDLLHLVGRPEDLHNAQLVIGQEVATSLSTRGTDLKVERVVVTNEKVLGKKIRDLHVKQRYDVVIS 320
Cdd:PRK03818 241 DTLMVPSPDTIIQLGDLLHLVGQPEDLHKAQLVIGEEVDTSLSTRGTDLRSERVVVTNEKVLGKKLRDLHLKNKYGVVIS 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244 321 RLNRAGVELVASSSASLQFGDILNLVGRQEAIDAVAAELGNAQQKLQQVQMLPVFIGIGLGVLLGSIPLFIPGFPAALKL 400
Cdd:PRK03818 321 RLNRAGVELVASPDLSLQFGDILNLVGRPEAIDAVANVLGNAQQKLQQVQMLPVFIGIGLGVLLGSIPFFIPGFPAALKL 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244 401 GLAGGPLIMALILGRIGSIGKLYWFMPPSANLALRELGIVLFLAVVGLKSGGDFVATLTQGEGLSWIAYGIFITAIPLLT 480
Cdd:PRK03818 401 GLAGGPLIVALILGRIGSIGKLYWFMPPSANLALRELGIVLFLAVVGLKSGGDFVDTLVNGEGLSWIGYGFLITAVPLLI 480
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 496082244 481 VGILARMLAKMNYLTLCGMLAGSMTDPPALAFANNLHATSGAAALSYATVYPLVMFLRIITPQLLAVLFWGL 552
Cdd:PRK03818 481 VGILARMLAKMNYLTLCGMLAGSMTDPPALAFANNLHPTSGAAALSYATVYPLVMFLRIITPQLLAVLFWSL 552
YbjL COG2985
Uncharacterized membrane protein YbjL, putative transporter [General function prediction only]; ...
18-549 0e+00

Uncharacterized membrane protein YbjL, putative transporter [General function prediction only];


Pssm-ID: 442224 [Multi-domain]  Cd Length: 543  Bit Score: 662.20  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244  18 GLWIGNVKIRGVGFGIGGVLFGGIIVGHFvdqagvALSSPMLHFIQEFGLILFVYTIGIQVGPGFFASLRVSGLRLNLFA 97
Cdd:COG2985   22 GYLLGKIKIGGFSLGVAGVLFVGLLIGHF------GVTLHIPHFVKSLGLALFVYAIGLQVGPGFFASLKRDGLKLNLLA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244  98 ILIVILGGLVTAVLHKLFNIPLPVVLGIFSGAVTNTPALGAGQQILRDLGVPFEVVDQMGMSYAMAYPFGICGILLTMWL 177
Cdd:COG2985   96 VVVVVLGLLVALALAKLFGLDPGLAAGLFAGALTNTPALGAAQDALGKLGLSKQLSANPAVGYAVAYPFGVIGIILFVAL 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244 178 VRLFFRINVEKEAQRFEESSGNGHANLHTINVRVENPNLNQMAIQDVPMLNSDNIVCSRLKRGELLMVPAPGTLIQAGDL 257
Cdd:COG2985  176 LPKLFRIDLDAEAKKLEAGEGSAYPPLVTRAYRVTNPNLVGKTVAELEALLGTRVVISRIRRGGEIIVPTPDTVLQEGDI 255
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244 258 LHLVGRPEDLHNAQLVIGQEVATSlSTRGTDLKVERVVVTNEKVLGKKIRDLHVKQRYDVVISRLNRAGVELVASSSASL 337
Cdd:COG2985  256 VLVVGTREALEAAEALLGEEVDDS-ELLDSDLDVRRIVVTNKEVAGKTLGELNLRNRFGVVITRVRRGGVELPATPDTVL 334
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244 338 QFGDILNLVGRQEAIDAVAAELGNAQQKLQQVQMLPVFIGIGLGVLLGSIPLFIPGFPaALKLGLAGGPLIMALILGRIG 417
Cdd:COG2985  335 QLGDRLTVVGPKEDVERVAKLLGNSERKLSETDLLPLGLGIVLGLLLGSIPIPLPGIP-PLSLGLAGGPLIVGLLLGRLG 413
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244 418 SIGKLYWFMPPSANLALRELGIVLFLAVVGLKSGGDFVATLTQgEGLSWIAYGIFITAIPLLTVGILARMLAKMNYLTLC 497
Cdd:COG2985  414 RTGPLVGYMPPSANLLLRELGLALFLAVVGLSAGPGFVETLQE-SGLLLFLLGALVTLVPLLVVLLVGRYVLKLNYLILL 492
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|..
gi 496082244 498 GMLAGSMTDPPALAFANNLHAtSGAAALSYATVYPLVMFLRIITPQLLAVLF 549
Cdd:COG2985  493 GALAGAMTSPPALAAANEAAG-SDAPALGYATVYPLAMILLILLGQLLVLLL 543
YidE_YbjL_dupl TIGR01625
AspT/YidE/YbjL antiporter duplication domain; This model represents a domain that is ...
378-533 5.60e-49

AspT/YidE/YbjL antiporter duplication domain; This model represents a domain that is duplicated the aspartate-alanine antiporter AspT, as well as HI0035 of Haemophilus influenzae, YidE and YbjL of E. coli, and a number of other known or putative transporters. Member proteins may have 0, 1, or 2 copies of TrkA potassium uptake domain pfam02080 between the duplications. The domain contains several apparent transmembrane regions and is proposed here to act in transport. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 130686 [Multi-domain]  Cd Length: 154  Bit Score: 166.35  E-value: 5.60e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244  378 IGLGVLLGSIPLFIPGFPaaLKLGLAGGPLIMALILGRIGSIGKLYWFMPPSANLALRELGIVLFLAVVGLKSGGDFVAT 457
Cdd:TIGR01625   1 LALGLLLGKIPIGLPGFS--IKLGNAGGVLFVGLLLGHFGATGPLTWYIPFSANLFIREFGLMLFLYGVGLSAGPGFFSS 78
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 496082244  458 LTQGEGLSWIAYGIFITAIPLLTVGILARMLAKMNYLTLCGMLAGSMTDPPALAFANNLHATSGAAALSYATVYPL 533
Cdd:TIGR01625  79 LKDGGGLLRINGGALITVVPTLLVAVALIKLLRINYALTAGMLAGATTNTPALDAANDTLRTSDLPALGYATVYPL 154
Asp-Al_Ex pfam06826
Predicted Permease Membrane Region; This family represents five transmembrane helices that are ...
373-546 1.66e-45

Predicted Permease Membrane Region; This family represents five transmembrane helices that are normally found flanking (five either side) a pair of pfam02080 domains. This suggests that the paired regions form a ten helical structure, probably forming the pore, whereas the pfam02080) binds a ligand for export or regulation of the pore. Swiss:Q8L3K8 is described as a aspartate-alanine antiporter. In conjunction with Swiss:Q8L3K9 it forms a 'proton motive metabolic cycle catalyzed by an aspartate-alanine exchange'. The general conservation of domain architecture in this family suggests that they are functional orthologues.


Pssm-ID: 284291 [Multi-domain]  Cd Length: 167  Bit Score: 157.73  E-value: 1.66e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244  373 PVFIGIGLGVLLGSIPlfipgFPAALKLGLAGGPLIMALILGRIGSIGKLywFMPPSANLALRELGIVLFLAVVGLKSGG 452
Cdd:pfam06826   1 ALFLGIALGLLLGRIK-----ISGGFSLGVAGGVLIVGLLLGHFGSTGPT--FMPISALSFLRELGLALFLAAVGLSAGP 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244  453 DFVATLTQGeGLSWIAYGIFITAIPLLTVGILARMLAKMNYLTLCGMLAGSMTDPPALAFANNLHATSGAAALSYATVYP 532
Cdd:pfam06826  74 GFFSSLKKD-GLLLIGLALLVTVVPLLLALVLGKYVLKLDPGLLAGLLAGALTSTPALGAANDALAGSDIPALGYAVTYP 152
                         170
                  ....*....|....
gi 496082244  533 LVMFLRIITPQLLA 546
Cdd:pfam06826 153 FGVVGLILAGQVLA 166
 
Name Accession Description Interval E-value
PRK03818 PRK03818
putative transporter; Validated
1-552 0e+00

putative transporter; Validated


Pssm-ID: 179654 [Multi-domain]  Cd Length: 552  Bit Score: 955.47  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244   1 MSEIALTVSVLALVAVVGLWIGNVKIRGVGFGIGGVLFGGIIVGHFVDQAGVALSSPMLHFIQEFGLILFVYTIGIQVGP 80
Cdd:PRK03818   1 MSDIALTVSILALVAVVGLWIGNIKIRGVGLGIGGVLFGGIIVGHFVSQFGLTLDSDMLHFIQEFGLILFVYTIGIQVGP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244  81 GFFASLRVSGLRLNLFAILIVILGGLVTAVLHKLFNIPLPVVLGIFSGAVTNTPALGAGQQILRDLGVPFEVVDQMGMSY 160
Cdd:PRK03818  81 GFFSSLRKSGLRLNLFAVLIVILGGLVTAILHKLFGIPLPVMLGIFSGAVTNTPALGAGQQILRDLGTPGDLVDQMGMGY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244 161 AMAYPFGICGILLTMWLVRLFFRINVEKEAQRFEESSGNGHANLHTINVRVENPNLNQMAIQDVPMLNSDNIVCSRLKRG 240
Cdd:PRK03818 161 AMAYPFGICGILLSMWLIRLIFRINVDKEAQEFESSSGNGHELLQTINIRVENPNLHGKAIKDVPILNGDKFVCSRLKRG 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244 241 ELLMVPAPGTLIQAGDLLHLVGRPEDLHNAQLVIGQEVATSLSTRGTDLKVERVVVTNEKVLGKKIRDLHVKQRYDVVIS 320
Cdd:PRK03818 241 DTLMVPSPDTIIQLGDLLHLVGQPEDLHKAQLVIGEEVDTSLSTRGTDLRSERVVVTNEKVLGKKLRDLHLKNKYGVVIS 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244 321 RLNRAGVELVASSSASLQFGDILNLVGRQEAIDAVAAELGNAQQKLQQVQMLPVFIGIGLGVLLGSIPLFIPGFPAALKL 400
Cdd:PRK03818 321 RLNRAGVELVASPDLSLQFGDILNLVGRPEAIDAVANVLGNAQQKLQQVQMLPVFIGIGLGVLLGSIPFFIPGFPAALKL 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244 401 GLAGGPLIMALILGRIGSIGKLYWFMPPSANLALRELGIVLFLAVVGLKSGGDFVATLTQGEGLSWIAYGIFITAIPLLT 480
Cdd:PRK03818 401 GLAGGPLIVALILGRIGSIGKLYWFMPPSANLALRELGIVLFLAVVGLKSGGDFVDTLVNGEGLSWIGYGFLITAVPLLI 480
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 496082244 481 VGILARMLAKMNYLTLCGMLAGSMTDPPALAFANNLHATSGAAALSYATVYPLVMFLRIITPQLLAVLFWGL 552
Cdd:PRK03818 481 VGILARMLAKMNYLTLCGMLAGSMTDPPALAFANNLHPTSGAAALSYATVYPLVMFLRIITPQLLAVLFWSL 552
YbjL COG2985
Uncharacterized membrane protein YbjL, putative transporter [General function prediction only]; ...
18-549 0e+00

Uncharacterized membrane protein YbjL, putative transporter [General function prediction only];


Pssm-ID: 442224 [Multi-domain]  Cd Length: 543  Bit Score: 662.20  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244  18 GLWIGNVKIRGVGFGIGGVLFGGIIVGHFvdqagvALSSPMLHFIQEFGLILFVYTIGIQVGPGFFASLRVSGLRLNLFA 97
Cdd:COG2985   22 GYLLGKIKIGGFSLGVAGVLFVGLLIGHF------GVTLHIPHFVKSLGLALFVYAIGLQVGPGFFASLKRDGLKLNLLA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244  98 ILIVILGGLVTAVLHKLFNIPLPVVLGIFSGAVTNTPALGAGQQILRDLGVPFEVVDQMGMSYAMAYPFGICGILLTMWL 177
Cdd:COG2985   96 VVVVVLGLLVALALAKLFGLDPGLAAGLFAGALTNTPALGAAQDALGKLGLSKQLSANPAVGYAVAYPFGVIGIILFVAL 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244 178 VRLFFRINVEKEAQRFEESSGNGHANLHTINVRVENPNLNQMAIQDVPMLNSDNIVCSRLKRGELLMVPAPGTLIQAGDL 257
Cdd:COG2985  176 LPKLFRIDLDAEAKKLEAGEGSAYPPLVTRAYRVTNPNLVGKTVAELEALLGTRVVISRIRRGGEIIVPTPDTVLQEGDI 255
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244 258 LHLVGRPEDLHNAQLVIGQEVATSlSTRGTDLKVERVVVTNEKVLGKKIRDLHVKQRYDVVISRLNRAGVELVASSSASL 337
Cdd:COG2985  256 VLVVGTREALEAAEALLGEEVDDS-ELLDSDLDVRRIVVTNKEVAGKTLGELNLRNRFGVVITRVRRGGVELPATPDTVL 334
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244 338 QFGDILNLVGRQEAIDAVAAELGNAQQKLQQVQMLPVFIGIGLGVLLGSIPLFIPGFPaALKLGLAGGPLIMALILGRIG 417
Cdd:COG2985  335 QLGDRLTVVGPKEDVERVAKLLGNSERKLSETDLLPLGLGIVLGLLLGSIPIPLPGIP-PLSLGLAGGPLIVGLLLGRLG 413
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244 418 SIGKLYWFMPPSANLALRELGIVLFLAVVGLKSGGDFVATLTQgEGLSWIAYGIFITAIPLLTVGILARMLAKMNYLTLC 497
Cdd:COG2985  414 RTGPLVGYMPPSANLLLRELGLALFLAVVGLSAGPGFVETLQE-SGLLLFLLGALVTLVPLLVVLLVGRYVLKLNYLILL 492
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|..
gi 496082244 498 GMLAGSMTDPPALAFANNLHAtSGAAALSYATVYPLVMFLRIITPQLLAVLF 549
Cdd:COG2985  493 GALAGAMTSPPALAAANEAAG-SDAPALGYATVYPLAMILLILLGQLLVLLL 543
YidE_YbjL_dupl TIGR01625
AspT/YidE/YbjL antiporter duplication domain; This model represents a domain that is ...
378-533 5.60e-49

AspT/YidE/YbjL antiporter duplication domain; This model represents a domain that is duplicated the aspartate-alanine antiporter AspT, as well as HI0035 of Haemophilus influenzae, YidE and YbjL of E. coli, and a number of other known or putative transporters. Member proteins may have 0, 1, or 2 copies of TrkA potassium uptake domain pfam02080 between the duplications. The domain contains several apparent transmembrane regions and is proposed here to act in transport. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 130686 [Multi-domain]  Cd Length: 154  Bit Score: 166.35  E-value: 5.60e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244  378 IGLGVLLGSIPLFIPGFPaaLKLGLAGGPLIMALILGRIGSIGKLYWFMPPSANLALRELGIVLFLAVVGLKSGGDFVAT 457
Cdd:TIGR01625   1 LALGLLLGKIPIGLPGFS--IKLGNAGGVLFVGLLLGHFGATGPLTWYIPFSANLFIREFGLMLFLYGVGLSAGPGFFSS 78
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 496082244  458 LTQGEGLSWIAYGIFITAIPLLTVGILARMLAKMNYLTLCGMLAGSMTDPPALAFANNLHATSGAAALSYATVYPL 533
Cdd:TIGR01625  79 LKDGGGLLRINGGALITVVPTLLVAVALIKLLRINYALTAGMLAGATTNTPALDAANDTLRTSDLPALGYATVYPL 154
Asp-Al_Ex pfam06826
Predicted Permease Membrane Region; This family represents five transmembrane helices that are ...
373-546 1.66e-45

Predicted Permease Membrane Region; This family represents five transmembrane helices that are normally found flanking (five either side) a pair of pfam02080 domains. This suggests that the paired regions form a ten helical structure, probably forming the pore, whereas the pfam02080) binds a ligand for export or regulation of the pore. Swiss:Q8L3K8 is described as a aspartate-alanine antiporter. In conjunction with Swiss:Q8L3K9 it forms a 'proton motive metabolic cycle catalyzed by an aspartate-alanine exchange'. The general conservation of domain architecture in this family suggests that they are functional orthologues.


Pssm-ID: 284291 [Multi-domain]  Cd Length: 167  Bit Score: 157.73  E-value: 1.66e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244  373 PVFIGIGLGVLLGSIPlfipgFPAALKLGLAGGPLIMALILGRIGSIGKLywFMPPSANLALRELGIVLFLAVVGLKSGG 452
Cdd:pfam06826   1 ALFLGIALGLLLGRIK-----ISGGFSLGVAGGVLIVGLLLGHFGSTGPT--FMPISALSFLRELGLALFLAAVGLSAGP 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244  453 DFVATLTQGeGLSWIAYGIFITAIPLLTVGILARMLAKMNYLTLCGMLAGSMTDPPALAFANNLHATSGAAALSYATVYP 532
Cdd:pfam06826  74 GFFSSLKKD-GLLLIGLALLVTVVPLLLALVLGKYVLKLDPGLLAGLLAGALTSTPALGAANDALAGSDIPALGYAVTYP 152
                         170
                  ....*....|....
gi 496082244  533 LVMFLRIITPQLLA 546
Cdd:pfam06826 153 FGVVGLILAGQVLA 166
Asp-Al_Ex pfam06826
Predicted Permease Membrane Region; This family represents five transmembrane helices that are ...
18-180 8.59e-36

Predicted Permease Membrane Region; This family represents five transmembrane helices that are normally found flanking (five either side) a pair of pfam02080 domains. This suggests that the paired regions form a ten helical structure, probably forming the pore, whereas the pfam02080) binds a ligand for export or regulation of the pore. Swiss:Q8L3K8 is described as a aspartate-alanine antiporter. In conjunction with Swiss:Q8L3K9 it forms a 'proton motive metabolic cycle catalyzed by an aspartate-alanine exchange'. The general conservation of domain architecture in this family suggests that they are functional orthologues.


Pssm-ID: 284291 [Multi-domain]  Cd Length: 167  Bit Score: 131.54  E-value: 8.59e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244   18 GLWIGNVKI-RGVGFGI-GGVLFGGIIVGHFVDQAGVALSSPMLHFIQEFGLILFVYTIGIQVGPGFFASLRVSGLRLNL 95
Cdd:pfam06826   9 GLLLGRIKIsGGFSLGVaGGVLIVGLLLGHFGSTGPTFMPISALSFLRELGLALFLAAVGLSAGPGFFSSLKKDGLLLIG 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244   96 FAILIVILGGLVTAVLHK-LFNIPLPVVLGIFSGAVTNTPALGAGQQILRDLGVPfevvdqmGMSYAMAYPFGICGILLT 174
Cdd:pfam06826  89 LALLVTVVPLLLALVLGKyVLKLDPGLLAGLLAGALTSTPALGAANDALAGSDIP-------ALGYAVTYPFGVVGLILA 161

                  ....*.
gi 496082244  175 MWLVRL 180
Cdd:pfam06826 162 GQVLAK 167
YidE_YbjL_dupl TIGR01625
AspT/YidE/YbjL antiporter duplication domain; This model represents a domain that is ...
18-166 6.99e-32

AspT/YidE/YbjL antiporter duplication domain; This model represents a domain that is duplicated the aspartate-alanine antiporter AspT, as well as HI0035 of Haemophilus influenzae, YidE and YbjL of E. coli, and a number of other known or putative transporters. Member proteins may have 0, 1, or 2 copies of TrkA potassium uptake domain pfam02080 between the duplications. The domain contains several apparent transmembrane regions and is proposed here to act in transport. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 130686 [Multi-domain]  Cd Length: 154  Bit Score: 120.13  E-value: 6.99e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244   18 GLWIGNVKIRGVGFGI-----GGVLFGGIIVGHFVDQAGVALSSP--MLHFIQEFGLILFVYTIGIQVGPGFFASLRVSG 90
Cdd:TIGR01625   4 GLLLGKIPIGLPGFSIklgnaGGVLFVGLLLGHFGATGPLTWYIPfsANLFIREFGLMLFLYGVGLSAGPGFFSSLKDGG 83
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 496082244   91 --LRLNLFAILIVILGGLVTAVLHKLFNIPLPVVLGIFSGAVTNTPALGAGQQILRDlgvpfevVDQMGMSYAMAYPF 166
Cdd:TIGR01625  84 glLRINGGALITVVPTLLVAVALIKLLRINYALTAGMLAGATTNTPALDAANDTLRT-------SDLPALGYATVYPL 154
PRK04972 PRK04972
putative transporter; Provisional
18-550 5.73e-31

putative transporter; Provisional


Pssm-ID: 179905 [Multi-domain]  Cd Length: 558  Bit Score: 126.76  E-value: 5.73e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244  18 GLWIGNVKIRGVGFGIG-GVLFGGIIVGHfvdqAGVALSSPMLHFiqefGLILFVYTIGIQVGPGFFASLRVSGLRLNLF 96
Cdd:PRK04972  24 GLCLGKLRLGSIQLGNSiGVLVVSLLLGQ----QHFSINTDALNL----GFMLFIFCVGVEAGPNFFSIFFRDGKNYLML 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244  97 AILIVILGGLVTAVLHKLFNIPLPVVLGIFSGAVTNTPALGAGQQILR-------DLGVpfeVVDQMGMSYAMAYPFGIC 169
Cdd:PRK04972  96 ALVMVGSALVIALGLGKLFGWDIGLTAGMLAGSMTSTPVLVGAGDTLRhsgaesrQLSL---ALDNLSLGYALTYLIGLV 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244 170 GILLTMWLVRLFFRINVEKEAQRFEESSGNGHAN-----LHTINVRVENPNLNQMA----IQDVPMLNSDNIVCSRLKRG 240
Cdd:PRK04972 173 SLIVGARYLPKLQHQDLQTSAQQIARERGLDTDAqrkvyLPVIRAYRVGPELVAWTdgknLRELGIYRQTGCYIERIRRN 252
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244 241 ELLMVPAPGTLIQAGDLLHLVGRPeDLH---NAQLVIGQEVatsLSTRGTDLKV--ERVVVTNEKVLGKKIRDLHVKQrY 315
Cdd:PRK04972 253 GILANPDGDAVLQMGDEIALVGYP-DAHarlDPSFRNGKEV---FDRDLLDMRIvtEEIVVKNHNAVGKRLSQLKLTD-H 327
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244 316 DVVISRLNRAGVELVASSSASLQFGDILNLVGRQEAIDAVAAELGNAQQKLQQVQMLPVFIGIGLGVLLGSIPLFIPGFp 395
Cdd:PRK04972 328 GCFLNRVIRSQIEMPIDDNVVLNKGDVLQVSGDARRVKTIADRIGFISIHSQVTDLLAFCAFFIIGLMIGMITFQFSNF- 406
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244 396 aALKLGLAGGPLIMALILGRIGSIGKLYWFMPPSANLALRELGIVLFLAVVGLKSGGDFVATLTQgEGLSWIAYGIFITA 475
Cdd:PRK04972 407 -SFGIGNAAGLLFAGIMLGFLRANHPTFGYIPQGALNMVKEFGLMVFMAGVGLSAGSGINNGLGA-VGGQMLIAGLIVSL 484
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 496082244 476 IPLLTVGILARMLAKMNYLTLCGMLAGSMTDPPALAFANNlHATSGAAALSYATVYPLVMFLRIITPQLLaVLFW 550
Cdd:PRK04972 485 VPVVICFLFGAYVLRMNRALLFGAIMGARTCAPAMEIISD-TARSNIPALGYAGTYAIANVLLTLAGTLI-VIVW 557
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
291-359 5.18e-08

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 49.92  E-value: 5.18e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 496082244  291 VERVVVTNEKVLGKKIRDLHVKQRYDVVISRLNRAGVELVASSSASLQFGDILNLVGRQEAIDAVAAEL 359
Cdd:pfam02080   2 VEVTVPENSPLVGKTLKELNLPERFGVRIVAIRRGGRLIIPSGDTVLEAGDRLLVIGTPDDLAALRELL 70
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
231-359 1.96e-04

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 41.83  E-value: 1.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244 231 NIVCSRLKRGELLMVPAPGTLIQAGDLLHLVGRPEDLHNAQLVIGQEVATSLSTRGTDLKVERVVVTNE-KVLGKKIRDL 309
Cdd:COG0490   10 IILLLLLALAALLVAIVIVGVLGLILRGLLLLELALLLLLLGELLRLLTRLLIELVLLLAIEEVKVPPGsPLVGKTLGEL 89
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 496082244 310 HVKQRYDVVISRLNRAGVELVA-SSSASLQFGDILNLVGRQEAIDAVAAEL 359
Cdd:COG0490   90 NLRQRTGVTVVAIRRGGEVILSpGPDTVLEAGDTLVVVGTREQLERLEELL 140
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
211-268 2.47e-04

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 39.51  E-value: 2.47e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 496082244  211 VENPNLNQMAIQDVPMLNSDNIVCSRLKRGELLMVPAPGTLIQAGDLLHLVGRPEDLH 268
Cdd:pfam02080   7 PENSPLVGKTLKELNLPERFGVRIVAIRRGGRLIIPSGDTVLEAGDRLLVIGTPDDLA 64
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
270-343 1.57e-03

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 40.82  E-value: 1.57e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 496082244 270 AQLVIGQEVATSLSTRGTDLKVERVVVT-NEKVLGKKIRDLHVKQRYDVVISRLNRAGVELVASSSASLQFGDIL 343
Cdd:COG0569  221 ARLLLRPGVLDVLELADGDAEIVEVTVPeGSPLVGKTLKELDLRERYGVTVVAIKRGGEVIIPSGDTVLEAGDEL 295
COG3273 COG3273
Uncharacterized protein, contains PhoU and TrkA_C domains [General function prediction only];
235-361 4.80e-03

Uncharacterized protein, contains PhoU and TrkA_C domains [General function prediction only];


Pssm-ID: 442504 [Multi-domain]  Cd Length: 387  Bit Score: 39.65  E-value: 4.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244 235 SRLKRGELLMVPAPGTLIQAGDLLHLVGRPEDLHNAQLVIGQEVATSLST--------RGTDLKVERVVVTNEKVL-GKK 305
Cdd:COG3273  251 SRLEAWVLRAARRVDDPVALRGLLHLASSTEVISDAALDIAEGVLRGLEDhpvvaeavRESDERIVRVTVPPGSPLvGKT 330
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 496082244 306 IRDLHVKQRYDVVISRLNRAG-VELVASSSASLQFGDILNLVGRQEAIDAVAAELGN 361
Cdd:COG3273  331 LGELKLETETGVRVIAIRRGGgWIYDPDGDTRLRAGDVLIVKGTREGLERLEELAGG 387
PRK04972 PRK04972
putative transporter; Provisional
366-513 6.11e-03

putative transporter; Provisional


Pssm-ID: 179905 [Multi-domain]  Cd Length: 558  Bit Score: 39.32  E-value: 6.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244 366 LQQVQMLPVFIGIGLGVLLGSIPLfipgfpAALKLGLAGGPLIMALILGRIGsigklYWFMPPSANLalrelGIVLFLAV 445
Cdd:PRK04972   9 LNGNYILLLFVVLALGLCLGKLRL------GSIQLGNSIGVLVVSLLLGQQH-----FSINTDALNL-----GFMLFIFC 72
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 496082244 446 VGLKSGGDFVAT-LTQGEGLSWIAYGIFITAIpLLTVGiLARMLAkMNYLTLCGMLAGSMTDPPALAFA 513
Cdd:PRK04972  73 VGVEAGPNFFSIfFRDGKNYLMLALVMVGSAL-VIALG-LGKLFG-WDIGLTAGMLAGSMTSTPVLVGA 138
Lys_export pfam03956
Lysine exporter LysO; Members of this family contain a conserved core of four predicted ...
35-128 9.37e-03

Lysine exporter LysO; Members of this family contain a conserved core of four predicted transmembrane segments. Some members have an additional pair of N-terminal transmembrane helices. This family includes lysine exporter LysO (YbjE) from E. coli.


Pssm-ID: 427613  Cd Length: 190  Bit Score: 37.40  E-value: 9.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082244   35 GVLFGGIIVGHFVDQAGVALSSPMLhfiqEFGLILFVYTIGIQVG--PGFFASLRVSGLRLnLFAILIVILGGLVTAVL- 111
Cdd:pfam03956   2 AFFIAGILLGYFLLPPADLLLDDLS----TYALYLLLFLVGIDLGsnRSLLQILRRLGPRI-LLLPLATILGSLLGGALa 76
                          90
                  ....*....|....*..
gi 496082244  112 HKLFNIPLPVVLGIFSG 128
Cdd:pfam03956  77 SLLLGLSLKESLAVGSG 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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