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Conserved domains on  [gi|496038032|ref|WP_008762539|]
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MULTISPECIES: sugar MFS transporter [Bacteroides]

Protein Classification

sugar MFS transporter( domain architecture ID 13024430)

sugar major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of sugar substrates including glucose, galactose, mannose and fucose

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_FucP_like cd17394
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ...
 17-431 1.77e-119

Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340952 [Multi-domain]  Cd Length: 401  Bit Score: 354.22  E-value: 1.77e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032  17 LAILAGMFFIFGFVSWVNSILIPYFRISCELTHFESYFVAFAFYIAYFVMAIPSGILLKKVGFKKGIMYGFMLTALGAFI 96
Cdd:cd17394    1 LALVTSLFFLWGFATNLNDILIPQFKNIFDLSNFQASLVQFAFFGAYFIMAIPAGMLIKRYGYKKGILLGLGLYAIGALL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032  97 FVPAALARQFEIFLIGLFSIGTGLAILQTAANPYVTIIGPIDSAARRISIMGICNKVAGIISPLIFAALILKANDSELFA 176
Cdd:cd17394   81 FIPAASLRTYGLFLIALFVLASGLALLQTAANPYVTVLGPEETAARRLNLAQAFNSLGSTIAPLFGSYLILSGIPSTATA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032 177 LIesgALDEATKNAMLNELIQRVIIPYIILGIILLLTGIGIRYSVLPEINTDEqnatDEQDNKHTDKKSILDFPYLILGA 256
Cdd:cd17394  161 LA---AMSAAELQAYKTAELASVQLPYLGIALVLLLLAVLILLSKLPEIEAAE----AEALGSKGTLLRLLKNPHLRLGV 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032 257 LAIFFHVGTQVIAIDTIINYAN--SMGMDLLEAKVFPSYTLGCTMIGYILGIILIpKYISQKNALIGCTLLGLALSFGVV 334
Cdd:cd17394  234 LAIFFYVGAEVAIWSFLINYLMeyIAGLTETSAATFVSYYWGGFMVGRFLGTALL-KKISPKKLLAVFALLGLLLLLGAI 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032 335 WAdfdmtlfghQANASIFFLNALGFPNALIYAGIWPLSIHGLGKFTKTGSSLLIMGLCGNAILPLVYGHFA-DQYSLRIG 413
Cdd:cd17394  313 FT---------GGMVALYALVLVGFFNSIMFPTIFSLALKGLGKHTKTGSGLLVMAIVGGAVVPLIQGAVAdDAAGLRIA 383

                        410
                 ....*....|....*...
gi 496038032 414 YWVLIPCFIYLVFFAIKG 431
Cdd:cd17394  384 FLVPLLCFAYILFYGLRG 401
 
Name Accession Description Interval E-value
MFS_FucP_like cd17394
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ...
 17-431 1.77e-119

Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340952 [Multi-domain]  Cd Length: 401  Bit Score: 354.22  E-value: 1.77e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032  17 LAILAGMFFIFGFVSWVNSILIPYFRISCELTHFESYFVAFAFYIAYFVMAIPSGILLKKVGFKKGIMYGFMLTALGAFI 96
Cdd:cd17394    1 LALVTSLFFLWGFATNLNDILIPQFKNIFDLSNFQASLVQFAFFGAYFIMAIPAGMLIKRYGYKKGILLGLGLYAIGALL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032  97 FVPAALARQFEIFLIGLFSIGTGLAILQTAANPYVTIIGPIDSAARRISIMGICNKVAGIISPLIFAALILKANDSELFA 176
Cdd:cd17394   81 FIPAASLRTYGLFLIALFVLASGLALLQTAANPYVTVLGPEETAARRLNLAQAFNSLGSTIAPLFGSYLILSGIPSTATA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032 177 LIesgALDEATKNAMLNELIQRVIIPYIILGIILLLTGIGIRYSVLPEINTDEqnatDEQDNKHTDKKSILDFPYLILGA 256
Cdd:cd17394  161 LA---AMSAAELQAYKTAELASVQLPYLGIALVLLLLAVLILLSKLPEIEAAE----AEALGSKGTLLRLLKNPHLRLGV 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032 257 LAIFFHVGTQVIAIDTIINYAN--SMGMDLLEAKVFPSYTLGCTMIGYILGIILIpKYISQKNALIGCTLLGLALSFGVV 334
Cdd:cd17394  234 LAIFFYVGAEVAIWSFLINYLMeyIAGLTETSAATFVSYYWGGFMVGRFLGTALL-KKISPKKLLAVFALLGLLLLLGAI 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032 335 WAdfdmtlfghQANASIFFLNALGFPNALIYAGIWPLSIHGLGKFTKTGSSLLIMGLCGNAILPLVYGHFA-DQYSLRIG 413
Cdd:cd17394  313 FT---------GGMVALYALVLVGFFNSIMFPTIFSLALKGLGKHTKTGSGLLVMAIVGGAVVPLIQGAVAdDAAGLRIA 383

                        410
                 ....*....|....*...
gi 496038032 414 YWVLIPCFIYLVFFAIKG 431
Cdd:cd17394  384 FLVPLLCFAYILFYGLRG 401
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
10-438 4.64e-71

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 229.36  E-value: 4.64e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032  10 KKTYYISLAILAGMFFIFGFVSWVNSILIPYFRISCELTHFESYFVAFAFYIAYFVMAIPSGILLKKVGFKKGIMYGFML 89
Cdd:COG0738    3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032  90 TALGAFIFvpaALARQFEIFLIGLFSIGTGLAILQTAANPYVTIIGPiDSAARRISIMGICNKVAGIISPLIFAALILKA 169
Cdd:COG0738   83 MALGLLLF---ALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGP-ETAASRLNLLHAFFSLGALLGPLLGGLLILLG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032 170 NDSElfaliesgaldeatknamlneliqrVIIPYIILGIILLLTGIGIRYSVLPEINTDEqnatDEQDNKHTDKKSILDF 249
Cdd:COG0738  159 LSLS-------------------------WHLPYLILAVLLLLLALLFLRSKLPEIEEEE----EEAAGSAASLKSLLKN 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032 250 PYLILGALAIFFHVGTQVIAIDTIINYA-NSMGMDLLEAKVFPSYTLGCTMIGYILGIILIpKYISQKNALIGCTLLGLA 328
Cdd:COG0738  210 PRLLLGGLAIFLYVGAEGAIGDWLPLYLkDVLGLSEATAALGLSLFWGGMTIGRFLGGFLL-KRFGPVRLLRLSALLAAV 288

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032 329 LSFGVVwadfdmtlFGHQANASIFFLNALGFPNALIYAGIWPLSIHGLGKFT-KTGSSLLIMGLCGNAILPLVYGHFADQ 407
Cdd:COG0738  289 GLLLAL--------LAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTaAAVSAVLIMGIVGGAIGPPLIGFLADA 360

                        410       420       430
                 ....*....|....*....|....*....|.
gi 496038032 408 YSLRIGYWVLIPCFIYLVFFAIKGHKINSWR 438
Cdd:COG0738  361 FGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
gluP TIGR01272
glucose/galactose transporter; This model describes the glucose/galactose transporter in ...
 97-427 6.26e-55

glucose/galactose transporter; This model describes the glucose/galactose transporter in bacteria. This belongs to the larger facilitator superfamily. Disruption of the loci leads to the total loss of glucose or galactose uptake in E.coli. Putative transporters in other bacterial species were isolated by functional complementation, which restored it functional activity. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273531 [Multi-domain]  Cd Length: 310  Bit Score: 184.71  E-value: 6.26e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032   97 FVPAALARQFEIFLIGLFSIGTGLAILQTAANPYVTIIGPIDSAARRISIMGICNKVAGIISPLIFAALILkandselfa 176
Cdd:TIGR01272   1 FGPAASQRYYVLFLGALFVLASGLTILQVAANPYVSILGPIETAASRLALTQAFNKLGTTVAPLFGGSLIL--------- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032  177 lieSGALDEATKNAMLNELIQRVIIPYIILGIILLLTGIGIRYSVLPEINTDEQNATDEQDnkHTDKKSILDFPYLILGA 256
Cdd:TIGR01272  72 ---SGAGDLSMQVATANAEAAKVHTPYLLLAGALAVLAIIFAFLPLPELQEADVARVSSGD--TTQKTSAFQFTHLVLGA 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032  257 LAIFFHVGTQVIAIDTIINY---ANSMGMDLLEAKVFPSYTLGCTMIGYILGIILIPkYISQKNALIGCTLLGLALSFGV 333
Cdd:TIGR01272 147 LGIFVYVGAEVSAGSFLVNFlsdPHALGLPEDQAAHFTAYTWGGAMVGRFIGSAVMP-MISQGRYLAFNAFLAVLLSIGA 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032  334 vwadfdMTLFGHQANASIFflnALGFPNALIYAGIWPLSIHGLGKFTKTGSSLLIMGLCGNAILPLVYGHFADQYSLRIG 413
Cdd:TIGR01272 226 ------ALTHGYVAMWFVL---ALGLFNSIMFPTIFSLALNALGRHTSQGSGILCLAIVGGAIVPLLQGSLADCLGIQLA 296

                         330
                  ....*....|....
gi 496038032  414 YWVLIPCFIYLVFF 427
Cdd:TIGR01272 297 FALPVPCYLYILFY 310
PRK10133 PRK10133
L-fucose:H+ symporter permease;
7-428 5.47e-36

L-fucose:H+ symporter permease;


Pssm-ID: 182260 [Multi-domain]  Cd Length: 438  Bit Score: 137.33  E-value: 5.47e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032   7 SARKKTYYISLAILAGMFFIFGFVSWVNSILIPYFRISCELTHFESYFVAFAFYIAYFVMAIPSGILLKKVGFKKGIMYG 86
Cdd:PRK10133  18 AGQSRSYIIPFALLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIITG 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032  87 FMLTALGAFIFVPAALARQFEIFLIGLFSIGTGLAILQTAANPYVTIIGPIDSAARRISIMGICNKVAGIISPLIFAALI 166
Cdd:PRK10133  98 LFLYALGAALFWPAAEIMNYTLFLVGLFIIAAGLGCLETAANPFVTVLGPESSGHFRLNLAQTFNSFGAIIAVVFGQSLI 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032 167 LKANDSElfaliESGALDEATKNAML---NELIQRVIIPYIILGIILLLTGIGIRYSVLPEINTDEQNATdEQDNKHTDK 243
Cdd:PRK10133 178 LSNVPHQ-----SQDVLDKMTPEQLSaykHSLVLSVQTPYMIIVAIVLLVALLIMLTKFPALQSDNHSDA-KQGSFSASL 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032 244 KSILDFPYLILGALAIFFHVGTQVIAIDTIINYA--NSMGMDLLEAKVFPSYTLGCTMIGYILGIILIPKYISQKnALIG 321
Cdd:PRK10133 252 SRLARIRHWRWAVLAQFCYVGAQTACWSYLIRYAveEIPGMTAGFAANYLTGTMVCFFIGRFTGTWLISRFAPHK-VLAA 330

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032 322 CTLLGLALSFGVVWADfdmtlfGHQANASIFFLNALgfpNALIYAGIWPLSIHGLGKFTKTGSSLLIMGLCGNAILPLVY 401
Cdd:PRK10133 331 YALIAMALCLISAFAG------GHVGLIALTLCSAF---MSIQYPTIFSLGIKNLGQDTKYGSSFIVMTIIGGGIVTPVM 401

                        410       420
                 ....*....|....*....|....*....
gi 496038032 402 GHFADQYSlRIGYWVLIP--CFIYLVFFA 428
Cdd:PRK10133 402 GFVSDAAG-NIPTAELIPalCFAVIFIFA 429
MFS_1 pfam07690
Major Facilitator Superfamily;
20-159 3.69e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 51.65  E-value: 3.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032   20 LAGMFFIFGFVSWVNSILIPYFRISCELTHFESYFVAFAFYIAYFVMAIPSGILLKKVGFKKGIMYGFMLTALGAFIFVP 99
Cdd:pfam07690 205 LLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLL 284

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032  100 AALARQFEIFLIGLFSIGTGLAILQTAANPYVTIIGPIDSAARRISIMGICNKVAGIISP 159
Cdd:pfam07690 285 LSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
 
Name Accession Description Interval E-value
MFS_FucP_like cd17394
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ...
 17-431 1.77e-119

Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340952 [Multi-domain]  Cd Length: 401  Bit Score: 354.22  E-value: 1.77e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032  17 LAILAGMFFIFGFVSWVNSILIPYFRISCELTHFESYFVAFAFYIAYFVMAIPSGILLKKVGFKKGIMYGFMLTALGAFI 96
Cdd:cd17394    1 LALVTSLFFLWGFATNLNDILIPQFKNIFDLSNFQASLVQFAFFGAYFIMAIPAGMLIKRYGYKKGILLGLGLYAIGALL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032  97 FVPAALARQFEIFLIGLFSIGTGLAILQTAANPYVTIIGPIDSAARRISIMGICNKVAGIISPLIFAALILKANDSELFA 176
Cdd:cd17394   81 FIPAASLRTYGLFLIALFVLASGLALLQTAANPYVTVLGPEETAARRLNLAQAFNSLGSTIAPLFGSYLILSGIPSTATA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032 177 LIesgALDEATKNAMLNELIQRVIIPYIILGIILLLTGIGIRYSVLPEINTDEqnatDEQDNKHTDKKSILDFPYLILGA 256
Cdd:cd17394  161 LA---AMSAAELQAYKTAELASVQLPYLGIALVLLLLAVLILLSKLPEIEAAE----AEALGSKGTLLRLLKNPHLRLGV 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032 257 LAIFFHVGTQVIAIDTIINYAN--SMGMDLLEAKVFPSYTLGCTMIGYILGIILIpKYISQKNALIGCTLLGLALSFGVV 334
Cdd:cd17394  234 LAIFFYVGAEVAIWSFLINYLMeyIAGLTETSAATFVSYYWGGFMVGRFLGTALL-KKISPKKLLAVFALLGLLLLLGAI 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032 335 WAdfdmtlfghQANASIFFLNALGFPNALIYAGIWPLSIHGLGKFTKTGSSLLIMGLCGNAILPLVYGHFA-DQYSLRIG 413
Cdd:cd17394  313 FT---------GGMVALYALVLVGFFNSIMFPTIFSLALKGLGKHTKTGSGLLVMAIVGGAVVPLIQGAVAdDAAGLRIA 383

                        410
                 ....*....|....*...
gi 496038032 414 YWVLIPCFIYLVFFAIKG 431
Cdd:cd17394  384 FLVPLLCFAYILFYGLRG 401
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
10-438 4.64e-71

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 229.36  E-value: 4.64e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032  10 KKTYYISLAILAGMFFIFGFVSWVNSILIPYFRISCELTHFESYFVAFAFYIAYFVMAIPSGILLKKVGFKKGIMYGFML 89
Cdd:COG0738    3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032  90 TALGAFIFvpaALARQFEIFLIGLFSIGTGLAILQTAANPYVTIIGPiDSAARRISIMGICNKVAGIISPLIFAALILKA 169
Cdd:COG0738   83 MALGLLLF---ALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGP-ETAASRLNLLHAFFSLGALLGPLLGGLLILLG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032 170 NDSElfaliesgaldeatknamlneliqrVIIPYIILGIILLLTGIGIRYSVLPEINTDEqnatDEQDNKHTDKKSILDF 249
Cdd:COG0738  159 LSLS-------------------------WHLPYLILAVLLLLLALLFLRSKLPEIEEEE----EEAAGSAASLKSLLKN 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032 250 PYLILGALAIFFHVGTQVIAIDTIINYA-NSMGMDLLEAKVFPSYTLGCTMIGYILGIILIpKYISQKNALIGCTLLGLA 328
Cdd:COG0738  210 PRLLLGGLAIFLYVGAEGAIGDWLPLYLkDVLGLSEATAALGLSLFWGGMTIGRFLGGFLL-KRFGPVRLLRLSALLAAV 288

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032 329 LSFGVVwadfdmtlFGHQANASIFFLNALGFPNALIYAGIWPLSIHGLGKFT-KTGSSLLIMGLCGNAILPLVYGHFADQ 407
Cdd:COG0738  289 GLLLAL--------LAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTaAAVSAVLIMGIVGGAIGPPLIGFLADA 360

                        410       420       430
                 ....*....|....*....|....*....|.
gi 496038032 408 YSLRIGYWVLIPCFIYLVFFAIKGHKINSWR 438
Cdd:COG0738  361 FGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
gluP TIGR01272
glucose/galactose transporter; This model describes the glucose/galactose transporter in ...
 97-427 6.26e-55

glucose/galactose transporter; This model describes the glucose/galactose transporter in bacteria. This belongs to the larger facilitator superfamily. Disruption of the loci leads to the total loss of glucose or galactose uptake in E.coli. Putative transporters in other bacterial species were isolated by functional complementation, which restored it functional activity. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273531 [Multi-domain]  Cd Length: 310  Bit Score: 184.71  E-value: 6.26e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032   97 FVPAALARQFEIFLIGLFSIGTGLAILQTAANPYVTIIGPIDSAARRISIMGICNKVAGIISPLIFAALILkandselfa 176
Cdd:TIGR01272   1 FGPAASQRYYVLFLGALFVLASGLTILQVAANPYVSILGPIETAASRLALTQAFNKLGTTVAPLFGGSLIL--------- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032  177 lieSGALDEATKNAMLNELIQRVIIPYIILGIILLLTGIGIRYSVLPEINTDEQNATDEQDnkHTDKKSILDFPYLILGA 256
Cdd:TIGR01272  72 ---SGAGDLSMQVATANAEAAKVHTPYLLLAGALAVLAIIFAFLPLPELQEADVARVSSGD--TTQKTSAFQFTHLVLGA 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032  257 LAIFFHVGTQVIAIDTIINY---ANSMGMDLLEAKVFPSYTLGCTMIGYILGIILIPkYISQKNALIGCTLLGLALSFGV 333
Cdd:TIGR01272 147 LGIFVYVGAEVSAGSFLVNFlsdPHALGLPEDQAAHFTAYTWGGAMVGRFIGSAVMP-MISQGRYLAFNAFLAVLLSIGA 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032  334 vwadfdMTLFGHQANASIFflnALGFPNALIYAGIWPLSIHGLGKFTKTGSSLLIMGLCGNAILPLVYGHFADQYSLRIG 413
Cdd:TIGR01272 226 ------ALTHGYVAMWFVL---ALGLFNSIMFPTIFSLALNALGRHTSQGSGILCLAIVGGAIVPLLQGSLADCLGIQLA 296

                         330
                  ....*....|....
gi 496038032  414 YWVLIPCFIYLVFF 427
Cdd:TIGR01272 297 FALPVPCYLYILFY 310
fucP TIGR00885
L-fucose:H+ symporter permease; This family describes the L-fucose permease in bacteria. ...
 13-427 8.94e-37

L-fucose:H+ symporter permease; This family describes the L-fucose permease in bacteria. L-fucose(6-deoxy-L-galactose) is a monosaccharide found in glycoproteins and cell wall polysaccharides. L-fucose is used in bacteria through an inducible pathway mediated by atleast four enzymes: a permease, isomerase, kinase and an aldolase which are encoded by fucP, fucI, fucK, fucA respectively. The fuc genes belong to a regulon comprising of four linked operons: fucO, fucA, fucPIK and fucR. The positive regulator is encoded by fucR, whose protein responds to fuculose-1-phosphate, which acts as an effector. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 211614  Cd Length: 408  Bit Score: 139.22  E-value: 8.94e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032   13 YYISLAILAGMFFIFGFVSWVNSILIPYFRISCELTHFESYFVAFAFYIAYFVMAIPSGILLKKVGFKKGIMYGFMLTAL 92
Cdd:TIGR00885   1 YIIPFALITSLFALWGFANDITNPMVPQFQQAFTLTAFQAALVQSAFYGGYFIMAIPAAIFMKKLSYKAGILLGLFLYAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032   93 GAFIFVPAALARQFEIFLIGLFSIGTGLAILQTAANPYVTIIGPIDSAARRISIMGICNKVAGIISPLIFAALILKANDS 172
Cdd:TIGR00885  81 GAFLFWPAAEIMNYTLFLVGLFILTAGLGFLETAANPYILVMGPESTATRRLNLAQSFNPFGSIIGMVVAQQLILSNLPH 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032  173 ElfALIESGALDEATKNAMLNELIQRVIIPYIILGIILLLTGIGIRYSVLPEINTDEQNatdeQDNKHTDKKSILDFPYL 252
Cdd:TIGR00885 161 Q--SQDVLDKLSPEELSAIKHSDLASVQTPYMIIGAVVLAVALLIMLTKMPALNHSDAK----QISFSASLSRLARIRHY 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032  253 ILGALAIFFHVGTQVIAIDTIINYANSMGMDLLE--AKVFPSYTLGCTMIGYILGIILIpKYISQKNALIGCTLLGLALS 330
Cdd:TIGR00885 235 REGVIAQFFYVGVQIMCWTFIIQYAVRLIPGMTAgfAANYNIGAMVIFFISRFIGTWLI-SYLAAHKVLMAYAIIGMALC 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032  331 FGVVWADfdmtlfghqanaSIFFLNALGFPNA---LIYAGIWPLSIHGLGKFTKTGSSLLIMGLCGNAILPLVYGHFADQ 407
Cdd:TIGR00885 314 LGSIFAG------------GHVGLYCLTLCSAfmsLMFPTIYGIALKGLGQDTKYGAAGLVMAIIGGGIVPPLQGFIIDM 381

                         410       420
                  ....*....|....*....|....
gi 496038032  408 YSLR----IGYWVLIPCFIYLVFF 427
Cdd:TIGR00885 382 KEIAaapaVNTSFILPLLCFAVIF 405
PRK10133 PRK10133
L-fucose:H+ symporter permease;
7-428 5.47e-36

L-fucose:H+ symporter permease;


Pssm-ID: 182260 [Multi-domain]  Cd Length: 438  Bit Score: 137.33  E-value: 5.47e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032   7 SARKKTYYISLAILAGMFFIFGFVSWVNSILIPYFRISCELTHFESYFVAFAFYIAYFVMAIPSGILLKKVGFKKGIMYG 86
Cdd:PRK10133  18 AGQSRSYIIPFALLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIITG 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032  87 FMLTALGAFIFVPAALARQFEIFLIGLFSIGTGLAILQTAANPYVTIIGPIDSAARRISIMGICNKVAGIISPLIFAALI 166
Cdd:PRK10133  98 LFLYALGAALFWPAAEIMNYTLFLVGLFIIAAGLGCLETAANPFVTVLGPESSGHFRLNLAQTFNSFGAIIAVVFGQSLI 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032 167 LKANDSElfaliESGALDEATKNAML---NELIQRVIIPYIILGIILLLTGIGIRYSVLPEINTDEQNATdEQDNKHTDK 243
Cdd:PRK10133 178 LSNVPHQ-----SQDVLDKMTPEQLSaykHSLVLSVQTPYMIIVAIVLLVALLIMLTKFPALQSDNHSDA-KQGSFSASL 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032 244 KSILDFPYLILGALAIFFHVGTQVIAIDTIINYA--NSMGMDLLEAKVFPSYTLGCTMIGYILGIILIPKYISQKnALIG 321
Cdd:PRK10133 252 SRLARIRHWRWAVLAQFCYVGAQTACWSYLIRYAveEIPGMTAGFAANYLTGTMVCFFIGRFTGTWLISRFAPHK-VLAA 330

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032 322 CTLLGLALSFGVVWADfdmtlfGHQANASIFFLNALgfpNALIYAGIWPLSIHGLGKFTKTGSSLLIMGLCGNAILPLVY 401
Cdd:PRK10133 331 YALIAMALCLISAFAG------GHVGLIALTLCSAF---MSIQYPTIFSLGIKNLGQDTKYGSSFIVMTIIGGGIVTPVM 401

                        410       420
                 ....*....|....*....|....*....
gi 496038032 402 GHFADQYSlRIGYWVLIP--CFIYLVFFA 428
Cdd:PRK10133 402 GFVSDAAG-NIPTAELIPalCFAVIFIFA 429
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
7-166 3.53e-12

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 67.20  E-value: 3.53e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032   7 SARKKTYYISLAILAGMFFIFGFVSWVNSILIPYFRISCELTHFESYFVAFAFYIAYFVMAIPSGILLKKVGFKKGIMYG 86
Cdd:COG2271    2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032  87 FMLTALGAFIFvpaALARQFEIFLIGLFSIGTGLAILQTAANPYVTIIGPIDSAARRISIMGICNKVAGIISPLIFAALI 166
Cdd:COG2271   82 LLLWGLATLLF---GFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLL 158
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 23-430 3.72e-11

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 64.26  E-value: 3.72e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032  23 MFFIFGFVSWVNSILIPYFRISCELTHFESYFVAFAFYIAYFVMAIPSGILLKKVGFKKGIMYGFMLTALGAFIFvpaAL 102
Cdd:cd17333    4 SFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALI---FA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032 103 ARQFEIFLIGLFSIGTGLAILQTAANPYVTIIGPiDSAARRISIMGICNKVAGIISPLIFAALILKANDSELFALIesga 182
Cdd:cd17333   81 TPSIYLFVVLMFLAGLGAGILDTGANTFVGALFE-ESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLI---- 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032 183 ldeatknamlneliqrviipYIILGIILLLTGIGIRYSVLPeintDEQNATDEQDNKHTDKKSILDFPYLILGALAIFFH 262
Cdd:cd17333  156 --------------------IGLIYLLLAILILLTLFPELP----SARNPQQSVGAFSASASRLLRNPSIILGALALFLY 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032 263 VGTQVIAIDTIINYA-NSMGMDLLEAKVFPSYTLGCTMIGYILGIILIPKYISQKNALIGCtLLGLALSFGVVWADFDMT 341
Cdd:cd17333  212 VGAETAFSSWVPSYLvEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSG-SGALLGLLILLLAPTLVV 290

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032 342 LFghQANASIFFLNALGFPNALIYAgiwplSIHGLGKFTKTGSSLLIMGLCGNAILPLVYGHFADQYSLRIGYWVLIPCF 421
Cdd:cd17333  291 GL--VATALLGLFMAALFPTILSLG-----ISNLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILY 363


                 ....*....
gi 496038032 422 IYLVFFAIK 430
Cdd:cd17333  364 AIIFVLALL 372
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
7-166 2.65e-10

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 61.53  E-value: 2.65e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032   7 SARKKTYYISLAILAGMFFIFGFVSWVNSILIPYFRISCELTHFESYFVAFAFYIAYFVMAIPSGILLKKVGFKKGIMYG 86
Cdd:COG2814    2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032  87 FMLTALGAFIfvpAALARQFEIFLIGLFSIGTGLAILQTAANPYVTIIGPIDSAARRISIMGICNKVAGIISPLIFAALI 166
Cdd:COG2814   82 LLLFALGSLL---CALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLA 158
MFS_1 pfam07690
Major Facilitator Superfamily;
20-159 3.69e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 51.65  E-value: 3.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032   20 LAGMFFIFGFVSWVNSILIPYFRISCELTHFESYFVAFAFYIAYFVMAIPSGILLKKVGFKKGIMYGFMLTALGAFIFVP 99
Cdd:pfam07690 205 LLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLL 284

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032  100 AALARQFEIFLIGLFSIGTGLAILQTAANPYVTIIGPIDSAARRISIMGICNKVAGIISP 159
Cdd:pfam07690 285 LSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 20-167 6.35e-07

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 51.27  E-value: 6.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032  20 LAGMFFIFGFVSWVNSILIPYFRISCELTHFESYFVAFAFYIAYFVMAIPSGILLKKVGFKKGIMYGFMLTALGAFIFvp 99
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLF-- 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 496038032 100 aALARQFEIFLIGLFSIGTGLAILQTAANPYVTIIGPIDSAARRISIMGICNKVAGIISPLIFAALIL 167
Cdd:cd06174   79 -AFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAS 145
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
17-165 1.03e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 50.67  E-value: 1.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032  17 LAILAGMFFIFGFVSWVNSILIPYFRISCELTHFESYFVAFAFYIAYFVMAIPSGILLKKVGFKKGIMYGFMLTALGaFI 96
Cdd:COG2211  231 LLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG-LL 309

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 496038032  97 FVPAALARQFEIFLIGLFSIGTGLAILQTAANPYVTIIGPIDSAARRI-------SIMGICNKVAGIISPLIFAAL 165
Cdd:COG2211  310 LLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRrreglyfGIFTFAIKLGQALAGALAGLL 385
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 19-167 2.11e-06

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 49.49  E-value: 2.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032  19 ILAGMFFIFGFVSWVN----SILIPYFRISCELTHFESYFVAFAFYIAYFVMAIPSGILLKKVGFKKGIMYGFMLTALGA 94
Cdd:cd17319    3 RIIPLLFLAYVINYLDrvniSVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFT 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 496038032  95 FIFvpaALARQFEIFLIGLFSIGTGLAILQTAANPYVTIIGPIDSAARRISIMGICNKVAGIISPLIFAALIL 167
Cdd:cd17319   83 ALT---GFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLL 152
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
17-155 2.89e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 49.20  E-value: 2.89e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032  17 LAILAGMFFIFGFVSWVNSILIPYFRISCELTHFESYFVAFAFYIAYFVMAIPSGILLKKVGFKKGIMYGFMLTALGAFI 96
Cdd:COG2814  210 LLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLL 289

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 496038032  97 FvpaALARQFEIFLIGLFSIGTGLAILQTAANPYVTIIGPIDSAARRISIMGICNKVAG 155
Cdd:COG2814  290 L---ALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
MFS_1 pfam07690
Major Facilitator Superfamily;
19-166 3.10e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 48.95  E-value: 3.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032   19 ILAGMFFIFGFVSWVNSILIPYFRISCELTHFESYFVAFAFYIAYFVMAIPSGILLKKVGFKKGIMYGFMLTALGAFIFV 98
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 496038032   99 PAAlarQFEIFLIGLFSIGTGLAILQTAANPYVTIIGPIDSAARRISIMGICNKVAGIISPLIFAALI 166
Cdd:pfam07690  81 FAS---SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA 145
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 15-128 3.28e-06

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 49.09  E-value: 3.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032  15 ISLAILAGMFFIFGFVSwVNSILIPYFRISCELTHFESYFVAFAFYIAYFVMAIPSGILLKKVGFKKGIMYGFMLTALGA 94
Cdd:cd17321  170 FSGAVLAAFLLGAALGG-LLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGL 248

                         90       100       110
                 ....*....|....*....|....*....|....
gi 496038032  95 FIFVPAALARQFEIFLIGLFSIGTGLAILQTAAN 128
Cdd:cd17321  249 LLLALLGADSSVWLLLPGLVLLGLGLGLFATPLT 282
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 16-166 1.07e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 47.19  E-value: 1.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032  16 SLAILAGMFFIFGFVSWVNSILIP-YFRISCELTHFESYFVAFAFYIAYFVMAIPSGILLKKVGFKKGIMYGFMLTALGA 94
Cdd:cd17325  200 RLLALFLAIFVLAFAFGALEPFLPlYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVAL 279

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 496038032  95 FIFvpaALARQFEIFLIGLFSIGTGLAILQTAANPYVTIIGPIDSAARRISIMGICNKVAGIISPLIFAALI 166
Cdd:cd17325  280 LLL---PLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLY 348
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
12-166 1.52e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 46.79  E-value: 1.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032  12 TYYISLAILAGMFFIFGFVSWvnsiLIPYFRISCELTHFESYFVAFAFYIAYFVMAIPSGILLKKVGFKKGIMYGFMLTA 91
Cdd:COG2271  182 FWLLALAYFLVYFALYGFLTW----LPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLL 257

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 496038032  92 LGAFIFVpAALARQFEIFLIGLFSIGTGLAILQTAANPYVTIIGPIDSAARRISIMGICNKVAGIISPLIFAALI 166
Cdd:COG2271  258 AALALLL-LALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLL 331
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
9-166 3.75e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 45.64  E-value: 3.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032   9 RKKTYYISLAILAGMFFIFGFVSWvnsiLIPYFRISCELTHFESYFVAFAFYIAYFVMAIPSGILLKKVGFKKGIMYGFM 88
Cdd:COG2223  204 DPRFWLLSLLYFGTFGSFIGFSSW----LPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFA 279

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 496038032  89 LTALGAFIFvpAALARQFEIFLIGLFSIGTGLAILQTAANPYVTIIGPIDSAARRISIMGICNKVAGIISPLIFAALI 166
Cdd:COG2223  280 LMALGLLLL--ALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALL 355
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 19-161 1.15e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 44.12  E-value: 1.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032  19 ILAGMFFIFGFVSWVNSILiPYFRISCELTHFESYFVAFAFYIAYFVMAIPSGILLKKVGFKKGIMYGFMLTALGAFIFV 98
Cdd:cd17489    1 ILLANFFFFLSFYLLLPVL-PLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 496038032  99 PAAlarQFEIFLIGLFSIGTGLAILQTAANPYVTIIGPIDSAARRISIMGICNKVAGIISPLI 161
Cdd:cd17489   80 LAT---SVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPAL 139
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 9-166 6.05e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 42.03  E-value: 6.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032   9 RKKTYYISLAILAGMFFIFGFVSWVNSILIPYFRISCElthfESYFVAFAFYIAYFVMAIPSGILLKKVGFKKGIMYGFM 88
Cdd:cd06174  202 NPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVA----VAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGL 277

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 496038032  89 LtaLGAFIFVPAALARQFEIFLIGLFSIGTGLAILQTAANPYVTIIGPIDSAARRISIMGICNKVAGIISPLIFAALI 166
Cdd:cd06174  278 L--LMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLL 353
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 20-128 6.55e-04

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 41.79  E-value: 6.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032  20 LAGMFFIFGFVSWVNSILIPYFRISCELTHFESYFVAFAFYIAYFVMAIPSGILLKKVGFKKGIMYGFMLTALGAFIFVP 99
Cdd:cd17503  184 LLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAF 263

                         90       100
                 ....*....|....*....|....*....
gi 496038032 100 AALARQFEIFLIGLFSIGTGLAILQTAAN 128
Cdd:cd17503  264 LTPDTSLWLIILPLFIRGLGMGLVFMPLN 292
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 9-178 1.50e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 40.66  E-value: 1.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032   9 RKKTYYISLAILAGMFFIFGFVSWVNSilipYFRISCELTHFESYFVAFAFYIAYFVMAIPSGILLKKVGFKKGIMYGFM 88
Cdd:cd17316  176 RRRTLLLILLWFFISFGYYGLTTFLPT----YLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLI 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032  89 LTALGAFIFVPAALARQFEIFLIGLFSIGTGLAIlQTAANPYVTIIGPIDSAARRISIMGICNKVAGIISPLIFAALILK 168
Cdd:cd17316  252 LSGILALPLFYLLSGSPTLLLLLLFILSFFVGGV-WGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAS 330

                        170
                 ....*....|
gi 496038032 169 ANDSELFALI 178
Cdd:cd17316  331 TGGTGVPALI 340
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 3-166 2.27e-03

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 39.79  E-value: 2.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032   3 NNQPSARKKTYYISLAILAGMFFIFGFVSWVNSILIPYFRISCELTHFESYFVAFAFYIAYFVMAIPSGILLKKVGFKKG 82
Cdd:COG0477    2 SSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032  83 IMYGFMLTALGAFIfvpAALARQFEIFLIGLFSIGTGLAILQTAANPYVTIIGPIDSAARRISIMGICNKVAGIISPLIF 162
Cdd:COG0477   82 LLIGLLLFGLASLL---CGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLG 158


                 ....
gi 496038032 163 AALI 166
Cdd:COG0477  159 GLLV 162
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 17-177 4.08e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 39.14  E-value: 4.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032  17 LAILAGMFFIFGFVSWVNSILIPYFRISCELTHFESYFVAFAFYIAYFVMAIPSGILLKKVGFKKGIMYGFMLTALGAFI 96
Cdd:cd06173  211 RLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLV 290

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496038032  97 FvpaALARQFEIFLIGLFSIGTGLAILQTAANPYVTIIGPIDSAARRISIMGICNKVAGIISPLIFAALILKANDSELFA 176
Cdd:cd06173  291 L---GLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFL 367


                 .
gi 496038032 177 L 177
Cdd:cd06173  368 L 368
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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