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Conserved domains on  [gi|495965044|ref|WP_008689623|]
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MULTISPECIES: sugar isomerase domain-containing protein [Longicatena]

Protein Classification

COG4821 family protein( domain architecture ID 10790904)

COG4821 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4821 COG4821
Uncharacterized conserved protein, contains SIS (Sugar ISomerase) phosphosugar binding domain ...
 7-237 4.74e-95

Uncharacterized conserved protein, contains SIS (Sugar ISomerase) phosphosugar binding domain [General function prediction only];


:

Pssm-ID: 443849 [Multi-domain]  Cd Length: 250  Bit Score: 278.62  E-value: 4.74e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495965044   7 YHEVVMKAMENATKTNEDAIEKGAKLMADAVQNGHTLYTFGTGHSHMIGQDVYARAGGYAKIYPIIEIEMTL---ATHPT 83
Cdd:COG4821    8 YLDEVRELLDRIEETQAEAIEKAADLIADSIAAGGLVHLFGTGHSHLLAEEVFYRAGGLVGFNPILDPSLMLhngAPGVL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495965044  84 KSTHVERTAAYADVLDVLYHIEDGDVIIATSNSGRNPLVIEYMMRAKAKGAKIIAITSLSHSKTIKSRHESGKRLFELAD 163
Cdd:COG4821   88 QSSFLERVEGYAEIILENYPIRPGDVLIVISNSGRNAVPIEMALEAKERGLKVIAITSLEHSKAVPSRHSSGKRLFELAD 167

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 495965044 164 VVLDNVAPYGDAGVDIDK-ETRMGPISTLTGCYLAQLLMGCFVEDLKQRGVDAPVFKSSNMDGADAYNQKLFDAY 237
Cdd:COG4821  168 VVIDNCVPYGDAVLPLEGlDTKVGPVSTVAGAFILNSLVAEVAELLAERGIEPPVFRSANVPGGDEHNEALLEKY 242
 
Name Accession Description Interval E-value
COG4821 COG4821
Uncharacterized conserved protein, contains SIS (Sugar ISomerase) phosphosugar binding domain ...
 7-237 4.74e-95

Uncharacterized conserved protein, contains SIS (Sugar ISomerase) phosphosugar binding domain [General function prediction only];


Pssm-ID: 443849 [Multi-domain]  Cd Length: 250  Bit Score: 278.62  E-value: 4.74e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495965044   7 YHEVVMKAMENATKTNEDAIEKGAKLMADAVQNGHTLYTFGTGHSHMIGQDVYARAGGYAKIYPIIEIEMTL---ATHPT 83
Cdd:COG4821    8 YLDEVRELLDRIEETQAEAIEKAADLIADSIAAGGLVHLFGTGHSHLLAEEVFYRAGGLVGFNPILDPSLMLhngAPGVL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495965044  84 KSTHVERTAAYADVLDVLYHIEDGDVIIATSNSGRNPLVIEYMMRAKAKGAKIIAITSLSHSKTIKSRHESGKRLFELAD 163
Cdd:COG4821   88 QSSFLERVEGYAEIILENYPIRPGDVLIVISNSGRNAVPIEMALEAKERGLKVIAITSLEHSKAVPSRHSSGKRLFELAD 167

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 495965044 164 VVLDNVAPYGDAGVDIDK-ETRMGPISTLTGCYLAQLLMGCFVEDLKQRGVDAPVFKSSNMDGADAYNQKLFDAY 237
Cdd:COG4821  168 VVIDNCVPYGDAVLPLEGlDTKVGPVSTVAGAFILNSLVAEVAELLAERGIEPPVFRSANVPGGDEHNEALLEKY 242
PRK02947 PRK02947
sugar isomerase domain-containing protein;
1-237 3.15e-94

sugar isomerase domain-containing protein;


Pssm-ID: 179510 [Multi-domain]  Cd Length: 246  Bit Score: 276.37  E-value: 3.15e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495965044   1 MEFFKTYHEVVMKAMENATKTNEDAIEKGAKLMADAVQNGHTLYTFGTGHSHMIGQDVYARAGGYAKIYPIIEIEMTLAT 80
Cdd:PRK02947   1 TDMIDEYFDAVIELLERVRETQAEAIEKAADLIADSIRNGGLIYVFGTGHSHILAEEVFYRAGGLAPVNPILEPSLMLHE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495965044  81 HPTKSTHVERTAAYADVLDVLYHIEDGDVIIATSNSGRNPLVIEYMMRAKAKGAKIIAITSLSHSKTIKSRHESGKRLFE 160
Cdd:PRK02947  81 GAVASSYLERVEGYAKAILDRYDIRPGDVLIVVSNSGRNPVPIEMALEAKERGAKVIAVTSLAYSASVASRHSSGKRLAE 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 495965044 161 LADVVLDNVAPYGDAGVDIDK-ETRMGPISTLTGCYLAQLLMGCFVEDLKQRGVDAPVFKSSNMDGADAYNQKLFDAY 237
Cdd:PRK02947 161 VADVVLDNGAPKGDAVLEIPGlEAPVGPVSTVVGAAILNAIFAEVAERLVERGITPPVFLSANVDGGDEHNQALVEKY 238
SIS_2 pfam13580
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 15-141 1.65e-40

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.


Pssm-ID: 433326 [Multi-domain]  Cd Length: 138  Bit Score: 135.80  E-value: 1.65e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495965044   15 MENATKTNEDAIEKGAKLMADAVQNGHTLYTFGTGHSHMIGQDVYARAGGYAKIYPIIEIEMTLATHP--TKSTHVERTA 92
Cdd:pfam13580  10 LERVVETQADAIEKAADLIAASLANGGKVYAFGTGHSAAPAEELFARAGGLAGFEPILLPALALHTDAsaTISTALERDE 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 495965044   93 AYADVLDVLYHIEDGDVIIATSNSGRNPLVIEYMMRAKAKGAKIIAITS 141
Cdd:pfam13580  90 GYARQILALYPGRPGDVLIVISNSGINAVPVEAALEAKERGMKVIALTS 138
SIS_RpiR cd05013
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ...
 24-174 1.03e-19

RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate.


Pssm-ID: 240144 [Multi-domain]  Cd Length: 139  Bit Score: 81.89  E-value: 1.03e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495965044  24 DAIEKGAKLMADAvqngHTLYTFGTGHSHMIGQDVYARAGGYAKIypiieiemtlaTHPTKSTHVERTAAYadvldvlyH 103
Cdd:cd05013    1 EALEKAVDLLAKA----RRIYIFGVGSSGLVAEYLAYKLLRLGKP-----------VVLLSDPHLQLMSAA--------N 57

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 495965044 104 IEDGDVIIATSNSGRNPLVIEYMMRAKAKGAKIIAITSLSHSktiksrhesgkRLFELADVVLDNVAPYGD 174
Cdd:cd05013   58 LTPGDVVIAISFSGETKETVEAAEIAKERGAKVIAITDSANS-----------PLAKLADIVLLVSSEEGD 117
 
Name Accession Description Interval E-value
COG4821 COG4821
Uncharacterized conserved protein, contains SIS (Sugar ISomerase) phosphosugar binding domain ...
 7-237 4.74e-95

Uncharacterized conserved protein, contains SIS (Sugar ISomerase) phosphosugar binding domain [General function prediction only];


Pssm-ID: 443849 [Multi-domain]  Cd Length: 250  Bit Score: 278.62  E-value: 4.74e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495965044   7 YHEVVMKAMENATKTNEDAIEKGAKLMADAVQNGHTLYTFGTGHSHMIGQDVYARAGGYAKIYPIIEIEMTL---ATHPT 83
Cdd:COG4821    8 YLDEVRELLDRIEETQAEAIEKAADLIADSIAAGGLVHLFGTGHSHLLAEEVFYRAGGLVGFNPILDPSLMLhngAPGVL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495965044  84 KSTHVERTAAYADVLDVLYHIEDGDVIIATSNSGRNPLVIEYMMRAKAKGAKIIAITSLSHSKTIKSRHESGKRLFELAD 163
Cdd:COG4821   88 QSSFLERVEGYAEIILENYPIRPGDVLIVISNSGRNAVPIEMALEAKERGLKVIAITSLEHSKAVPSRHSSGKRLFELAD 167

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 495965044 164 VVLDNVAPYGDAGVDIDK-ETRMGPISTLTGCYLAQLLMGCFVEDLKQRGVDAPVFKSSNMDGADAYNQKLFDAY 237
Cdd:COG4821  168 VVIDNCVPYGDAVLPLEGlDTKVGPVSTVAGAFILNSLVAEVAELLAERGIEPPVFRSANVPGGDEHNEALLEKY 242
PRK02947 PRK02947
sugar isomerase domain-containing protein;
1-237 3.15e-94

sugar isomerase domain-containing protein;


Pssm-ID: 179510 [Multi-domain]  Cd Length: 246  Bit Score: 276.37  E-value: 3.15e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495965044   1 MEFFKTYHEVVMKAMENATKTNEDAIEKGAKLMADAVQNGHTLYTFGTGHSHMIGQDVYARAGGYAKIYPIIEIEMTLAT 80
Cdd:PRK02947   1 TDMIDEYFDAVIELLERVRETQAEAIEKAADLIADSIRNGGLIYVFGTGHSHILAEEVFYRAGGLAPVNPILEPSLMLHE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495965044  81 HPTKSTHVERTAAYADVLDVLYHIEDGDVIIATSNSGRNPLVIEYMMRAKAKGAKIIAITSLSHSKTIKSRHESGKRLFE 160
Cdd:PRK02947  81 GAVASSYLERVEGYAKAILDRYDIRPGDVLIVVSNSGRNPVPIEMALEAKERGAKVIAVTSLAYSASVASRHSSGKRLAE 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 495965044 161 LADVVLDNVAPYGDAGVDIDK-ETRMGPISTLTGCYLAQLLMGCFVEDLKQRGVDAPVFKSSNMDGADAYNQKLFDAY 237
Cdd:PRK02947 161 VADVVLDNGAPKGDAVLEIPGlEAPVGPVSTVVGAAILNAIFAEVAERLVERGITPPVFLSANVDGGDEHNQALVEKY 238
SIS_2 pfam13580
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 15-141 1.65e-40

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.


Pssm-ID: 433326 [Multi-domain]  Cd Length: 138  Bit Score: 135.80  E-value: 1.65e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495965044   15 MENATKTNEDAIEKGAKLMADAVQNGHTLYTFGTGHSHMIGQDVYARAGGYAKIYPIIEIEMTLATHP--TKSTHVERTA 92
Cdd:pfam13580  10 LERVVETQADAIEKAADLIAASLANGGKVYAFGTGHSAAPAEELFARAGGLAGFEPILLPALALHTDAsaTISTALERDE 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 495965044   93 AYADVLDVLYHIEDGDVIIATSNSGRNPLVIEYMMRAKAKGAKIIAITS 141
Cdd:pfam13580  90 GYARQILALYPGRPGDVLIVISNSGINAVPVEAALEAKERGMKVIALTS 138
SIS_RpiR cd05013
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ...
 24-174 1.03e-19

RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate.


Pssm-ID: 240144 [Multi-domain]  Cd Length: 139  Bit Score: 81.89  E-value: 1.03e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495965044  24 DAIEKGAKLMADAvqngHTLYTFGTGHSHMIGQDVYARAGGYAKIypiieiemtlaTHPTKSTHVERTAAYadvldvlyH 103
Cdd:cd05013    1 EALEKAVDLLAKA----RRIYIFGVGSSGLVAEYLAYKLLRLGKP-----------VVLLSDPHLQLMSAA--------N 57

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 495965044 104 IEDGDVIIATSNSGRNPLVIEYMMRAKAKGAKIIAITSLSHSktiksrhesgkRLFELADVVLDNVAPYGD 174
Cdd:cd05013   58 LTPGDVVIAISFSGETKETVEAAEIAKERGAKVIAITDSANS-----------PLAKLADIVLLVSSEEGD 117
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
 2-215 4.98e-14

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 69.57  E-value: 4.98e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495965044   2 EFFKTYHEVVMKAMENATKT-NEDAIEKGAKLMADAvqngHTLYTFGTGHSHMIGQDVY---ARAGGYAKIYPiieiemt 77
Cdd:COG1737   99 DILAKVLEAEIANLEETLELlDEEALERAVDLLAKA----RRIYIFGVGASAPVAEDLAyklLRLGKNVVLLD------- 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495965044  78 lathptksthvertAAYADVLDVLYHIEDGDVIIATSNSGRNPLVIEYMMRAKAKGAKIIAITSLSHSktiksrhesgkR 157
Cdd:COG1737  168 --------------GDGHLQAESAALLGPGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDSPLS-----------P 222

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 495965044 158 LFELADVVLDNVAPygdagvdiDKETRMGPISTLTGC-YLAQLLMGCFVEDLKQRGVDA 215
Cdd:COG1737  223 LAKLADVVLYVPSE--------EPTLRSSAFSSRVAQlALIDALAAAVAQRDGDKARER 273
SIS_GmhA cd05006
Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose ...
 6-166 9.67e-12

Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of gram-negative bacteria inner core lipopolysaccharide precursor, L-glycero-D-mannoheptose (Gmh).


Pssm-ID: 240139 [Multi-domain]  Cd Length: 177  Bit Score: 61.37  E-value: 9.67e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495965044   6 TYHEVVMKAMENAtktNEDAIEKGAKLMADAVQNGHTLYTFGTGHSHMIGQDVYA----RAGGYAKIYPIIeiemTLATH 81
Cdd:cd05006    2 QESIQLKEALLEL---LAEAIEQAAQLLAEALLNGGKILICGNGGSAADAQHFAAelvkRFEKERPGLPAI----ALTTD 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495965044  82 PTksthvERTAA-----YADVLD--VLYHIEDGDVIIATSNSGRNPLVIEYMMRAKAKGAKIIAITSlshsktiksrhES 154
Cdd:cd05006   75 TS-----ILTAIandygYEEVFSrqVEALGQPGDVLIGISTSGNSPNVLKALEAAKERGMKTIALTG-----------RD 138

                        170
                 ....*....|..
gi 495965044 155 GKRLFELADVVL 166
Cdd:cd05006  139 GGKLLELADIEI 150
PRK11337 PRK11337
MurR/RpiR family transcriptional regulator;
15-171 2.95e-08

MurR/RpiR family transcriptional regulator;


Pssm-ID: 183089 [Multi-domain]  Cd Length: 292  Bit Score: 53.23  E-value: 2.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495965044  15 MENATKTNEDAIEKGAKLMADAVQngHTLYtfGTGHSHMIGQDV---YARAGGYAKIYPIIEIEMTLAThptksthvert 91
Cdd:PRK11337 119 EETQSILDVDEFHRAARFFYQARQ--RDLY--GAGGSAAIARDVqhkFLRIGVRCQAYDDAHIMLMSAA----------- 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495965044  92 aayadvldVLyhiEDGDVIIATSNSGRNPLVIEYMMRAKAKGAKIIAITSLSHSKtiksrhesgkrLFELADVVLDNVAP 171
Cdd:PRK11337 184 --------LL---QEGDVVLVVSHSGRTSDVIEAVELAKKNGAKIICITNSYHSP-----------IAKLADYVICSTAQ 241
SIS pfam01380
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 41-145 5.79e-07

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway.


Pssm-ID: 426230 [Multi-domain]  Cd Length: 131  Bit Score: 47.29  E-value: 5.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495965044   41 HTLYTFGTGHSHMIGQdvyaraggyakiypiiEIEMTLATHPTKSTHVErtAAYADVLDVLYHIEDGDVIIATSNSGRNP 120
Cdd:pfam01380   6 KRIFVIGRGTSYAIAL----------------ELALKFEEIGYKVVEVE--LASELRHGVLALVDEDDLVIAISYSGETK 67

                          90       100
                  ....*....|....*....|....*
gi 495965044  121 LVIEYMMRAKAKGAKIIAITSLSHS 145
Cdd:pfam01380  68 DLLAAAELAKARGAKIIAITDSPGS 92
SIS_Kpsf cd05014
KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ...
 103-167 8.80e-07

KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-phosphate to arabinose 5-phosphate. This is the second step in the CMP-Kdo biosynthesis pathway.


Pssm-ID: 240145 [Multi-domain]  Cd Length: 128  Bit Score: 46.77  E-value: 8.80e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 495965044 103 HIEDGDVIIATSNSGRNPLVIEYMMRAKAKGAKIIAITSLSHSktiksrhesgkRLFELADVVLD 167
Cdd:cd05014   44 MVTPGDVVIAISNSGETDELLNLLPHLKRRGAPIIAITGNPNS-----------TLAKLSDVVLD 97
SIS_PHI cd05005
Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) ...
 104-166 1.08e-06

Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with formadelhyde to become hexulose-6-phosphate, which is then isomerized to fructose-6-phosphate by PHI.


Pssm-ID: 240138 [Multi-domain]  Cd Length: 179  Bit Score: 47.57  E-value: 1.08e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 495965044 104 IEDGDVIIATSNSGRNPLVIEYMMRAKAKGAKIIAITSLSHSktiksrhesgkRLFELADVVL 166
Cdd:cd05005   73 IGPGDLLIAISGSGETSSVVNAAEKAKKAGAKVVLITSNPDS-----------PLAKLADVVV 124
SIS_Etherase cd05007
N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ...
 25-141 1.20e-06

N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid carries a unique D-lactyl ether substituent at the C3 position. The etherase catalyzes the cleavage of the lactyl ether bond of N-acetylmuramic acid 6-phosphate.


Pssm-ID: 240140 [Multi-domain]  Cd Length: 257  Bit Score: 48.29  E-value: 1.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495965044  25 AIEKGAKLMADAVQNGHTLYTFGTGHSHMIG-QDVYARAGGY----AKIYPIIEIEMTLATHPTKSTHVERTAAYADVLD 99
Cdd:cd05007   34 QIARAVDAAAERLRAGGRLIYVGAGTSGRLGvLDASELPPTFgtppERVVGLIAGGEPALTRAVEGAEDDEEAGAADLQA 113

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 495965044 100 VlyHIEDGDVIIATSNSGRNPLVIEYMMRAKAKGAKIIAITS 141
Cdd:cd05007  114 I--NLTERDVVIGIAASGRTPYVLGALRYARARGALTIGIAC 153
PRK14101 PRK14101
bifunctional transcriptional regulator/glucokinase;
22-141 3.99e-06

bifunctional transcriptional regulator/glucokinase;


Pssm-ID: 184507 [Multi-domain]  Cd Length: 638  Bit Score: 47.22  E-value: 3.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495965044  22 NEDAIEKGAKLMADAvqngHTLYTFGTGHSHMIGQDVYARAGGYAkiYPIIeiemtlathptKSTHVERTAAYADVLDvl 101
Cdd:PRK14101 454 NFEHVEQAIDILNNA----RRIEFYGLGNSNIVAQDAHYKFFRFG--IPTI-----------AYGDLYMQAASAALLG-- 514

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 495965044 102 yhieDGDVIIATSNSGRNPLVIEYMMRAKAKGAKIIAITS 141
Cdd:PRK14101 515 ----KGDVIVAVSKSGRAPELLRVLDVAMQAGAKVIAITS 550
PRK13937 PRK13937
phosphoheptose isomerase; Provisional
 12-174 6.52e-06

phosphoheptose isomerase; Provisional


Pssm-ID: 184408 [Multi-domain]  Cd Length: 188  Bit Score: 45.23  E-value: 6.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495965044  12 MKAMENATKTNEDAIEKGAKLMADAVQNGHTLYTFGTGHS-----H----MIGQDVYARAGgyakiYPIIeiemTLATHP 82
Cdd:PRK13937  10 QAVMEAFLESLLEAIAKVAEALIEALANGGKILLCGNGGSaadaqHiaaeLVGRFKKERPA-----LPAI----ALTTDT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495965044  83 TKSTHVERTAAYADVLD--VLYHIEDGDVIIATSNSGRNPLVIEYMMRAKAKGAKIIAITSLshsktiksrheSGKRLFE 160
Cdd:PRK13937  81 SALTAIGNDYGFERVFSrqVEALGRPGDVLIGISTSGNSPNVLAALEKARELGMKTIGLTGR-----------DGGKMKE 149

                        170
                 ....*....|....
gi 495965044 161 LADVVLdnVAPYGD 174
Cdd:PRK13937 150 LCDHLL--IVPSDD 161
PRK15482 PRK15482
HTH-type transcriptional regulator MurR;
47-170 9.35e-06

HTH-type transcriptional regulator MurR;


Pssm-ID: 185379 [Multi-domain]  Cd Length: 285  Bit Score: 45.84  E-value: 9.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495965044  47 GTGHSHMIGQDVYaraggyakiYPIIEIEMTLATHptKSTHVERTAAYAdvldvlyhIEDGDVIIATSNSGRNPLVIEYM 126
Cdd:PRK15482 142 GLGGSALVGRDLS---------FKLMKIGYRVACE--ADTHVQATVSQA--------LKKGDVQIAISYSGSKKEIVLCA 202

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 495965044 127 MRAKAKGAKIIAITSLSHSKtiksrhesgkrLFELADVVLDNVA 170
Cdd:PRK15482 203 EAARKQGATVIAITSLADSP-----------LRRLAHFTLDTVS 235
gmhA PRK00414
D-sedoheptulose 7-phosphate isomerase;
18-164 9.44e-06

D-sedoheptulose 7-phosphate isomerase;


Pssm-ID: 179012 [Multi-domain]  Cd Length: 192  Bit Score: 44.73  E-value: 9.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495965044  18 ATKTNEDAIEKGAKLMADAVQNGHTLYTFGTGHSH---------MIGQDVYARAGgyakiYPIIEIemtlaTHPTKSTHV 88
Cdd:PRK00414  22 KDDANIHAIQRAAVLIADSFKAGGKVLSCGNGGSHcdamhfaeeLTGRYRENRPG-----YPAIAI-----SDVSHLSCV 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495965044  89 ERTAAYADVLDvlYHIE----DGDVIIATSNSGRNPLVIEYMMRAKAKGAKIIAITSlshsktiksrhESGKRLFELADV 164
Cdd:PRK00414  92 SNDFGYDYVFS--RYVEavgrEGDVLLGISTSGNSGNIIKAIEAARAKGMKVITLTG-----------KDGGKMAGLADI 158
GutQ COG0794
D-arabinose 5-phosphate isomerase GutQ [Carbohydrate transport and metabolism, Cell wall ...
 104-167 1.32e-04

D-arabinose 5-phosphate isomerase GutQ [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440557 [Multi-domain]  Cd Length: 317  Bit Score: 42.27  E-value: 1.32e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 495965044 104 IEDGDVIIATSNSGRNPLVIEYMMRAKAKGAKIIAITSLSHSktiksrhesgkRLFELADVVLD 167
Cdd:COG0794   89 ITPGDVVIAISNSGETEELLALLPLLKRLGVPLIAITGNPDS-----------TLARAADVVLD 141
murQ PRK05441
N-acetylmuramic acid-6-phosphate etherase; Reviewed
 25-141 1.70e-04

N-acetylmuramic acid-6-phosphate etherase; Reviewed


Pssm-ID: 235467 [Multi-domain]  Cd Length: 299  Bit Score: 41.69  E-value: 1.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495965044  25 AIEKGAKLMADAVQNGHTL-Y-------------------TFGTGHshmiGQDVYARAGGYAKIYPIIEiemtlathptk 84
Cdd:PRK05441  47 QIAAAVDAAAAALRQGGRLiYigagtsgrlgvldasecppTFGVPP----ELVVGLIAGGEKALTKAVE----------- 111

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 495965044  85 stHVE--RTAAYADVLDvlYHIEDGDVIIATSNSGRNPLVIEYMMRAKAKGAKIIAITS 141
Cdd:PRK05441 112 --GAEddAELGAADLKA--INLTAKDVVVGIAASGRTPYVIGALEYARERGALTIGISC 166
AgaS COG2222
Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain ...
 97-167 7.76e-04

Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441824 [Multi-domain]  Cd Length: 336  Bit Score: 39.88  E-value: 7.76e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 495965044  97 VLDVLYHIEDGDVIIATSNSGRNPLVIEYMMRAKAKGAKIIAITSlshsktiksrHESGKrLFELADVVLD 167
Cdd:COG2222   73 VVYPAYLKLEGTLVVAISRSGNSPEVVAALELAKARGARTLAITN----------NPDSP-LAEAADRVLP 132
SIS cd04795
SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 103-140 8.57e-03

SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.


Pssm-ID: 240112 [Multi-domain]  Cd Length: 87  Bit Score: 34.66  E-value: 8.57e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 495965044 103 HIEDGDVIIATSNSGRNPLVIEYMMRAKAKGAKIIAIT 140
Cdd:cd04795   44 LLRKGDVVIALSYSGRTEELLAALEIAKELGIPVIAIT 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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