|
Name |
Accession |
Description |
Interval |
E-value |
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
234-593 |
1.88e-77 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 250.62 E-value: 1.88e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 234 IIQIYKRLHETKEALYIEREKLITHLQISHEGLGVFTKDKKEILVNNLFTQYSNLISDSNLETTEEVFAISELKEIIHFI 313
Cdd:COG5002 30 LLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 314 NKNQQERSRGKGEKRMSVTINKNGRTFIVECIIFQDASFEISINDVTQEEEQVRLKRQLTQNIAHELKTPVSSIQGYLET 393
Cdd:COG5002 110 LLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLEL 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 394 IVSNENIPREKINVFLERCYAQSNRLSRLLRDISVLTRMDEAASMIDMERVDISVLVGNIINEVSLELDEKHITV-INSL 472
Cdd:COG5002 190 LLDGAADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELeLDLP 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 473 KKSIQVKGNYSLLYSIFRNLMDNAIAYAGSNIQININCfREDENFYYFSFADTGIGVSPEHLNRLFERFYRVDKGRSRKL 552
Cdd:COG5002 270 EDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSL-REEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRET 348
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 495920141 553 GGTGLGLAIVKNAVIIHGGNISAKNNQGGGLEFVFTLAKEK 593
Cdd:COG5002 349 GGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLAR 389
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
361-589 |
2.68e-64 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 210.92 E-value: 2.68e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 361 QEEEQVRLKRQLTQNIAHELKTPVSSIQGYLETIVSNENIPREKINVFLERCYAQSNRLSRLLRDISVLTRMDEAASMID 440
Cdd:COG2205 8 ELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLESGKLSLE 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 441 MERVDISVLVGNIINEVSLELDEKHITVINSL-KKSIQVKGNYSLLYSIFRNLMDNAIAYAGSNIQININCFREDENFyY 519
Cdd:COG2205 88 LEPVDLAELLEEAVEELRPLAEEKGIRLELDLpPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREGDGV-R 166
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 520 FSFADTGIGVSPEHLNRLFERFYRVDkgRSRKLGGTGLGLAIVKNAVIIHGGNISAKNNQGGGLEFVFTL 589
Cdd:COG2205 167 ISVSDNGPGIPEEELERIFERFYRGD--NSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTL 234
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
358-589 |
8.34e-60 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 202.05 E-value: 8.34e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 358 DVTQEE--EQVRlkRQLTQNIAHELKTPVSSIQGYLETIVSNENIPREKINVFLERCYAQSNRLSRLLRDISVLTRMDEA 435
Cdd:TIGR02966 103 DVTRLRrlEQMR--RDFVANVSHELRTPLTVLRGYLETLADGPDEDPEEWNRALEIMLEQSQRMQSLVEDLLTLSRLESA 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 436 ASMIDMERVDISVLVGNIINEVSLELDEKHITVINSLKKSIQVKGNYSLLYSIFRNLMDNAIAYAGSNIQINInCFREDE 515
Cdd:TIGR02966 181 ASPLEDEPVDMPALLDHLRDEAEALSQGKNHQITFEIDGGVDVLGDEDELRSAFSNLVSNAIKYTPEGGTITV-RWRRDG 259
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 495920141 516 NFYYFSFADTGIGVSPEHLNRLFERFYRVDKGRSRKLGGTGLGLAIVKNAVIIHGGNISAKNNQGGGLEFVFTL 589
Cdd:TIGR02966 260 GGAEFSVTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRHHARLEIESELGKGSTFSFIF 333
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
345-589 |
1.36e-57 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 196.28 E-value: 1.36e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 345 IIFQDASFEISINDVTQEEEQVRLKRQLTQNIAHELKTPVSSIQGYLETIVSNENiprEKINVFLERCYAQSNRLSRLLR 424
Cdd:COG0642 86 LLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELD---EEQREYLETILRSADRLLRLIN 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 425 DISVLTRMDEAASMIDMERVDISVLVGNIINEVSLELDEKHITVINSLKKSI-QVKGNYSLLYSIFRNLMDNAIAYAGSN 503
Cdd:COG0642 163 DLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLpTVRGDPDRLRQVLLNLLSNAIKYTPEG 242
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 504 IQININCfREDENFYYFSFADTGIGVSPEHLNRLFERFYRVDkgRSRKLGGTGLGLAIVKNAVIIHGGNISAKNNQGGGL 583
Cdd:COG0642 243 GTVTVSV-RREGDRVRISVEDTGPGIPPEDLERIFEPFFRTD--PSRRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGT 319
|
....*.
gi 495920141 584 EFVFTL 589
Cdd:COG0642 320 TFTVTL 325
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
172-589 |
2.32e-49 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 176.69 E-value: 2.32e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 172 YLWFTIIVTLLLMIIFYKFTNKLGTSISQLREFA---MRADRNEPIEMAMQsafphNELGEISQHIIQIYKRLHETKEAL 248
Cdd:COG5000 11 LLLIALLLLLLALWLALLLARRLTRPLRRLAEATravAAGDLSVRLPVTGD-----DEIGELARAFNRMTDQLKEQREEL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 249 YIEREKLITHLQISHEGLGVFTKDKKEILVNNLFTQYSNLISDSNL-ETTEEVFAISELKEIIhfinknqQERSRGKGEK 327
Cdd:COG5000 86 EERRRYLETILENLPAGVIVLDADGRITLANPAAERLLGIPLEELIgKPLEELLPELDLAELL-------REALERGWQE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 328 RMSVTINkNGRTFIVECIIFQDASFEISINDVTQEEEQVRLK--RQLTQNIAHELKTPVSSIQGYLETIVS--NENIP-- 401
Cdd:COG5000 159 EIELTRD-GRRTLLVRASPLRDDGYVIVFDDITELLRAERLAawGELARRIAHEIKNPLTPIQLSAERLRRklADKLEed 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 402 REKINVFLERCYAQSNRLSRLLRDISVLTRMDEAasmiDMERVDISVLVGNIINEVSLELDEKHITVINSLKKSI-QVKG 480
Cdd:COG5000 238 REDLERALDTIIRQVDRLKRIVDEFLDFARLPEP----QLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLpEVLA 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 481 NYSLLYSIFRNLMDNAIAYAGSNIQININCFREDeNFYYFSFADTGIGVSPEHLNRLFERFYrvdkgrSRKLGGTGLGLA 560
Cdd:COG5000 314 DRDQLEQVLINLLKNAIEAIEEGGEIEVSTRRED-GRVRIEVSDNGPGIPEEVLERIFEPFF------TTKPKGTGLGLA 386
|
410 420
....*....|....*....|....*....
gi 495920141 561 IVKNAVIIHGGNISAKNNQGGGLEFVFTL 589
Cdd:COG5000 387 IVKKIVEEHGGTIELESRPGGGTTFTIRL 415
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
358-591 |
7.51e-42 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 156.32 E-value: 7.51e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 358 DVTQEEEQVRLKRQLTQNIAHELKTPVSSIQGYLETIVSN--ENIPREK-INVFLErcyaQSNRLSRLLRDISVLTRMdE 434
Cdd:PRK11006 193 DVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQDQplEGALREKaLHTMRE----QTQRMEGLVKQLLTLSKI-E 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 435 AASMIDM-ERVDISVLVGNIINEVSLELDEKHiTVINSLKKSIQVKGNYSLLYSIFRNLMDNAIAY--AGSNIQIninCF 511
Cdd:PRK11006 268 AAPTIDLnEKVDVPMMLRVLEREAQTLSQGKH-TITFEVDNSLKVFGNEDQLRSAISNLVYNAVNHtpEGTHITV---RW 343
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 512 REDENFYYFSFADTGIGVSPEHLNRLFERFYRVDKGRSRKLGGTGLGLAIVKNAVIIHGGNISAKNNQGGGLEFVFTLAK 591
Cdd:PRK11006 344 QRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLPE 423
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
246-593 |
5.26e-38 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 147.24 E-value: 5.26e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 246 EALYIEREKLITHLQISHEGLGVFTKDKKEILVNNLFTQYSNLISDSNLETTEEVFAISELKEIIHFINKNQQERSRGKG 325
Cdd:COG4251 149 LLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLL 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 326 EKRMSVTINKNGRTFIVECIIFQDASFEISINDVTQEEEQVRLKRQLTQ-N---------IAHELKTPVSSIQGYLETIV 395
Cdd:COG4251 229 LLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAELERsNeeleqfayvASHDLREPLRKISGFSQLLE 308
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 396 SN-ENIPREKINVFLERCYAQSNRLSRLLRDISVLTRMDEAAsmIDMERVDISVLVGNIINEVSLELDEKHITV-INSLk 473
Cdd:COG4251 309 EDyGDKLDEEGREYLERIRDAAERMQALIDDLLAYSRVGRQE--LEFEPVDLNELLEEVLEDLEPRIEERGAEIeVGPL- 385
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 474 ksIQVKGNYSLLYSIFRNLMDNAIAYAGSNI--QININCfREDENFYYFSFADTGIGVSPEHLNRLFERFYRVDkgRSRK 551
Cdd:COG4251 386 --PTVRGDPTLLRQVFQNLISNAIKYSRPGEppRIEIGA-EREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLH--SRDE 460
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 495920141 552 LGGTGLGLAIVKNAVIIHGGNISAKNNQGGGLEFVFTLAKEK 593
Cdd:COG4251 461 YEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPKAP 502
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
371-589 |
1.44e-35 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 137.24 E-value: 1.44e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 371 QLTQNIAHELKTPVSSIQGYLETIVS--NENIPREKINVFLERCYAQSNRLSRLLRDISVLTRMDEAasmiDMERVDISV 448
Cdd:COG4191 144 ELAAGIAHEINNPLAAILGNAELLRRrlEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRDEE----EREPVDLNE 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 449 LVGNIINEVSLELDEKHITVINSLKKSI-QVKGNYSLLYSIFRNLMDNAI-AYAGSNI-QININCfREDENFYYFSFADT 525
Cdd:COG4191 220 LIDEALELLRPRLKARGIEVELDLPPDLpPVLGDPGQLEQVLLNLLINAIdAMEEGEGgRITIST-RREGDYVVISVRDN 298
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 495920141 526 GIGVSPEHLNRLFERFY---RVDKGrsrklggTGLGLAIVKNAVIIHGGNISAKNNQGGGLEFVFTL 589
Cdd:COG4191 299 GPGIPPEVLERIFEPFFttkPVGKG-------TGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITL 358
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
480-589 |
1.36e-30 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 115.44 E-value: 1.36e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 480 GNYSLLYSIFRNLMDNAIAYAGSNIQININCFREDENfYYFSFADTGIGVSPEHLNRLFERFYRVDKgRSRKLGGTGLGL 559
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDH-VEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGL 78
|
90 100 110
....*....|....*....|....*....|
gi 495920141 560 AIVKNAVIIHGGNISAKNNQGGGLEFVFTL 589
Cdd:smart00387 79 SIVKKLVELHGGEISVESEPGGGTTFTITL 108
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
362-590 |
1.63e-30 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 124.42 E-value: 1.63e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 362 EEEQVRLKrQLTQNIAHELKTPVSSIQGYLETIVSNENIPREKINVfLERCYAQSNRLSRLLRDISVLTRMDEAASMIDM 441
Cdd:TIGR01386 235 EDAFQRLS-QFSADLAHELRTPLTNLLGQTQVALSQPRTGEEYREV-LESNLEELERLSRMVSDMLFLARADNGQLALER 312
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 442 ERVDISVLVGNIINEVSLELDEKHITVinSLKKSIQVKGNYSLLYSIFRNLMDNAIAYAGSNIQININCfREDENFYYFS 521
Cdd:TIGR01386 313 VRLDLAAELAKVAEYFEPLAEERGVRI--RVEGEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRI-ERRSDEVRVS 389
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495920141 522 FADTGIGVSPEHLNRLFERFYRVDKGRSRKLGGTGLGLAIVKNAVIIHGGNISAKNNQGgglEFVFTLA 590
Cdd:TIGR01386 390 VSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDG---KTRFILR 455
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
356-589 |
3.58e-30 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 123.80 E-value: 3.58e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 356 INDVTQEEEQVRLK-------RQLTQNIAHELKTPVSSIQGYLETIvsNENIPREKINVFLERCYAQSNRLSRLLRDISV 428
Cdd:PRK11100 236 LRELAQALESMRVKlegkayvEQYVQTLTHELKSPLAAIRGAAELL--QEDPPPEDRARFTGNILTQSARLQQLIDRLLE 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 429 LTRMDEAASMIDMERVDISVLVGNIINEVSLELDEKHITVINSLKkSIQVKGNYSLLYSIFRNLMDNAIAYAGSNIQINI 508
Cdd:PRK11100 314 LARLEQRQELEVLEPVALAALLEELVEAREAQAAAKGITLRLRPD-DARVLGDPFLLRQALGNLLDNAIDFSPEGGTITL 392
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 509 NCFREDEnFYYFSFADTGIGVsPEH-LNRLFERFY---RVDKGRSrklgGTGLGLAIVKNAVIIHGGNISAKNNQGGGLE 584
Cdd:PRK11100 393 SAEVDGE-QVALSVEDQGPGI-PDYaLPRIFERFYslpRPANGRK----STGLGLAFVREVARLHGGEVTLRNRPEGGVL 466
|
....*
gi 495920141 585 FVFTL 589
Cdd:PRK11100 467 ATLTL 471
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
485-589 |
2.66e-29 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 111.54 E-value: 2.66e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 485 LYSIFRNLMDNAIAYA--GSNIQINIncfREDENFYYFSFADTGIGVSPEHLNRLFERFYRVDKgrSRKLGGTGLGLAIV 562
Cdd:cd00075 1 LEQVLSNLLDNALKYSppGGTIEISL---RQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDK--SREGGGTGLGLAIV 75
|
90 100
....*....|....*....|....*..
gi 495920141 563 KNAVIIHGGNISAKNNQGGGLEFVFTL 589
Cdd:cd00075 76 RRIVEAHGGRITVESEPGGGTTFTVTL 102
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
485-589 |
1.81e-28 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 109.34 E-value: 1.81e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 485 LYSIFRNLMDNAIAYAGSNIQININcfrEDENFYYFSFADTGIGVSPEHLNRLFERFYRVDKGRSRKLGGTGLGLAIVKN 564
Cdd:cd16949 1 LARALENVLRNALRYSPSKILLDIS---QDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAER 77
|
90 100
....*....|....*....|....*
gi 495920141 565 AVIIHGGNISAKNNQGGGLEFVFTL 589
Cdd:cd16949 78 AIEQHGGKIKASNRKPGGLRVRIWL 102
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
355-589 |
3.35e-28 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 117.73 E-value: 3.35e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 355 SINDVTQEEEQVRLKRQ-LTQNIAHELKTPVSSIQgyLETIV-------SNEniprekinvfLERCYAQSNRLSRLLRDI 426
Cdd:PRK09470 228 SFNQMVTALERMMTSQQrLLSDISHELRTPLTRLQ--LATALlrrrqgeSKE----------LERIETEAQRLDSMINDL 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 427 SVLTRMdEAASMIDMERVDISVLVGNIINEVSLELDEKHIT-VINSLKKSIQVKGNYSLLYSIFRNLMDNAIAYAGSNIQ 505
Cdd:PRK09470 296 LVLSRN-QQKNHLERETFKANSLWSEVLEDAKFEAEQMGKSlTVSAPPGPWPINGNPNALASALENIVRNALRYSHTKIE 374
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 506 ININCfreDENFYYFSFADTGIGVSPEHLNRLFERFYRVDKGRSRKLGGTGLGLAIVKNAVIIHGGNISAKNNQGGGLEF 585
Cdd:PRK09470 375 VAFSV---DKDGLTITVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRL 451
|
....
gi 495920141 586 VFTL 589
Cdd:PRK09470 452 TIWL 455
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
317-589 |
1.39e-27 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 114.17 E-value: 1.39e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 317 QQERSRGKGEKRMSVTI-NKNGRTFIVECII--FQDASFE----ISINDVTqeeEQVRLKRQLTQ------------NIA 377
Cdd:COG3852 67 ERALAEGQPVTEREVTLrRKDGEERPVDVSVspLRDAEGEggvlLVLRDIT---ERKRLERELRRaeklaavgelaaGLA 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 378 HELKTPVSSIQGYLETIvsNENIPREKINVFLERCYAQSNRLSRLLRDISVLTRMDEaasmIDMERVDISVLVGNIINEV 457
Cdd:COG3852 144 HEIRNPLTGIRGAAQLL--ERELPDDELREYTQLIIEEADRLNNLVDRLLSFSRPRP----PEREPVNLHEVLERVLELL 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 458 SLELDeKHITVINSLKKSI-QVKGNYSLLYSIFRNLMDNAIAYAGSNIQININCFRE---------DENFYYFSFADTGI 527
Cdd:COG3852 218 RAEAP-KNIRIVRDYDPSLpEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRVErqvtlgglrPRLYVRIEVIDNGP 296
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 495920141 528 GVSPEHLNRLFERFYrvdkgrSRKLGGTGLGLAIVKNAVIIHGGNISAKNNQGGGLEFVFTL 589
Cdd:COG3852 297 GIPEEILDRIFEPFF------TTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYL 352
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
364-583 |
2.17e-27 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 115.50 E-value: 2.17e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 364 EQVRlkRQLTQNIAHELKTPVSSIQGYLETIVSNENIPR-EKINVFLercyAQSNRLSRLLRDISVLTRMDEAASMIDME 442
Cdd:PRK10549 237 EQMR--RDFMADISHELRTPLAVLRGELEAIQDGVRKFTpESVASLQ----AEVGTLTKLVDDLHQLSLSDEGALAYRKT 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 443 RVDISVLVGNIINEVSLELDEKHITVINSLKKSIQVKGNYSLLYSIFRNLMDNAIAYAGSNIQININCFREDENFYyFSF 522
Cdd:PRK10549 311 PVDLVPLLEVAGGAFRERFASRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLR-LTF 389
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 495920141 523 ADTGIGVSPEHLNRLFERFYRVDKGRSRKLGGTGLGLAIVKNAVIIHGGNISAKNNQGGGL 583
Cdd:PRK10549 390 ADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGV 450
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
485-589 |
2.40e-26 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 103.31 E-value: 2.40e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 485 LYSIFRNLMDNAIAYAGSNIQININCFREDENfYYFSFADTGIGVSPEHLNRLFERFYRVDKGRSRKLGGTGLGLAIVKN 564
Cdd:cd16946 5 LQQLFVNLLENSLRYTDTGGKLRIRAAQTPQE-VRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAICHN 83
|
90 100
....*....|....*....|....*
gi 495920141 565 AVIIHGGNISAKNNQGGGLEFVFTL 589
Cdd:cd16946 84 IALAHGGTISAEHSPLGGLRLVLTL 108
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
485-590 |
6.46e-25 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 99.58 E-value: 6.46e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 485 LYSIFRNLMDNAIAYAGSNIQININcFREDENFYYFSFADTGIGVSPEHLNRLFERFYRVDKGRSRKLGGTGLGLAIVKN 564
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVR-WSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKH 79
|
90 100
....*....|....*....|....*.
gi 495920141 565 AVIIHGGNISAKNNQGGGLEFVFTLA 590
Cdd:cd16952 80 VMSRHDARLLIASELGKGSRFTCLFP 105
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
480-589 |
1.10e-24 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 98.59 E-value: 1.10e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 480 GNYSLLYSIFRNLMDNAI--AYAGSNIQINIncfrEDENFYYFSFADTGIGVSPEHLNRLFERFYRVDKgrsRKLGGTGL 557
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALkhAAKAGEITVTL----SEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGL 73
|
90 100 110
....*....|....*....|....*....|..
gi 495920141 558 GLAIVKNAVIIHGGNISAKNNQGGGLEFVFTL 589
Cdd:pfam02518 74 GLSIVRKLVELLGGTITVESEPGGGTTVTLTL 105
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
488-589 |
4.88e-24 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 96.79 E-value: 4.88e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 488 IFRNLMDNAIAY--AGSnIQININCFREDENFYY--FSFADTGIGVSPEHLNRLFERFYRVDKGRSRKLGGTGLGLAIVK 563
Cdd:cd16922 4 ILLNLLGNAIKFteEGE-VTLRVSLEEEEEDGVQlrFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAISK 82
|
90 100
....*....|....*....|....*.
gi 495920141 564 NAVIIHGGNISAKNNQGGGLEFVFTL 589
Cdd:cd16922 83 KLVELMGGDISVESEPGQGSTFTFTL 108
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
475-584 |
2.46e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 95.17 E-value: 2.46e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 475 SIQVKGNYSLLYSIFRNLMDNAIAY--AGSNIQINIncfrEDENFYYFSFADTGIGVSPEHLNRLFERFYRVDKgrsRKL 552
Cdd:cd16940 4 DIQVQGDALLLFLLLRNLVDNAVRYspQGSRVEIKL----SADDGAVIRVEDNGPGIDEEELEALFERFYRSDG---QNY 76
|
90 100 110
....*....|....*....|....*....|..
gi 495920141 553 GGTGLGLAIVKNAVIIHGGNISAKNNQGGGLE 584
Cdd:cd16940 77 GGSGLGLSIVKRIVELHGGQIFLGNAQGGGLE 108
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
354-591 |
2.64e-23 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 103.31 E-value: 2.64e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 354 ISINDVTQEEEQVrLKRQ--LTQNIAHELKTPVSSIQGYLETIVSNENIPREKINVF---LErcyaQSNRLSRLLRDISV 428
Cdd:PRK09835 246 LSFNHMIERIEDV-FTRQsnFSADIAHEIRTPITNLITQTEIALSQSRSQKELEDVLysnLE----ELTRMAKMVSDMLF 320
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 429 LTRMDEAASMIDMERVDISVLVGNIINEVSLELDEKHITvINSLKKSIQVKGNYSLLYSIFRNLMDNAIAY--AGSNIQI 506
Cdd:PRK09835 321 LAQADNNQLIPEKKMLDLADEVGKVFDFFEAWAEERGVE-LRFVGDPCQVAGDPLMLRRAISNLLSNALRYtpAGEAITV 399
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 507 NIncfREDENFYYFSFADTGIGVSPEHLNRLFERFYRVDKGRSRKLGGTGLGLAIVKNAVIIHGGNISAKNNqGGGLEFV 586
Cdd:PRK09835 400 RC---QEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSD-ARGTRFV 475
|
....*
gi 495920141 587 FTLAK 591
Cdd:PRK09835 476 ISLPR 480
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
262-589 |
9.37e-23 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 101.59 E-value: 9.37e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 262 SHEGLGVFTKDKKEILVNNLFTQYSNlISDSNLE--TTEEVFAISELKEIIHFINKNQQERSRGKGEKRmsvTINKNGRT 339
Cdd:COG5809 150 SPDGIIVTDLDGRIIYANPAACKLLG-ISIEELIgkSILELIHSDDQENVAAFISQLLKDGGIAQGEVR---FWTKDGRW 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 340 FIVECIIF------QDASFEISINDVTQEEEQVRLKR---------QLTQNIAHELKTPVSSIQGYLETIVSNENIPREK 404
Cdd:COG5809 226 RLLEASGApikkngEVDGIVIIFRDITERKKLEELLRkseklsvvgELAAGIAHEIRNPLTSLKGFIQLLKDTIDEEQKT 305
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 405 -INVFLErcyaQSNRLSRLLRDISVLTRmdeaASMIDMERVDISVLVGNIINEVSLELDEKHITVI-NSLKKSIQVKGNY 482
Cdd:COG5809 306 yLDIMLS----ELDRIESIISEFLVLAK----PQAIKYEPKDLNTLIEEVIPLLQPQALLKNVQIElELEDDIPDILGDE 377
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 483 SLLYSIFRNLMDNAIAYAGSNIQININCFREDENFYYFSFADTGIGVSPEHLNRLFERFYrvdkgrSRKLGGTGLGLAIV 562
Cdd:COG5809 378 NQLKQVFINLLKNAIEAMPEGGNITIETKAEDDDKVVISVTDEGCGIPEERLKKLGEPFY------TTKEKGTGLGLMVS 451
|
330 340
....*....|....*....|....*..
gi 495920141 563 KNAVIIHGGNISAKNNQGGGLEFVFTL 589
Cdd:COG5809 452 YKIIEEHGGKITVESEVGKGTTFSITL 478
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
370-584 |
3.33e-22 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 99.72 E-value: 3.33e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 370 RQLTQNIAHELKTPVSSIQGYLETIVSNENIP--REKInvfLERCYAQSNRLSRLLRDISVLTRMDEAASMIDMERVDIS 447
Cdd:PRK10337 238 RRFTSDAAHELRSPLAALKVQTEVAQLSDDDPqaRKKA---LLQLHAGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLE 314
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 448 VLVGNIINEVSLELDEKHITVINSLKKSIQVKGNYSLLYSIF-RNLMDNAIAY--AGSNIQININCFRedenfyyFSFAD 524
Cdd:PRK10337 315 DLLQSAVMDIYHTAQQAGIDVRLTLNAHPVIRTGQPLLLSLLvRNLLDNAIRYspQGSVVDVTLNARN-------FTVRD 387
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 525 TGIGVSPEHLNRLFERFYRvDKGRSRKlgGTGLGLAIVKNAVIIHGGNISAKNNQGGGLE 584
Cdd:PRK10337 388 NGPGVTPEALARIGERFYR-PPGQEAT--GSGLGLSIVRRIAKLHGMNVSFGNAPEGGFE 444
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
360-593 |
2.07e-20 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 95.87 E-value: 2.07e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 360 TQEEEQVRL--KRQLTQN-----IAHELKTPVSSIQGYLETI---VSNENIPrekinvflercYAQsnRLSRLLRDISVL 429
Cdd:PRK10490 648 TASEEQARLasEREQLRNallaaLSHDLRTPLTVLFGQAEILtldLASEGSP-----------HAR--QASEIRQQVLNT 714
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 430 TRMdeAASMIDMERVD------------ISVLVGNIINEVSLELDEKHITVinSLKKSIQ-VKGNYSLLYSIFRNLMDNA 496
Cdd:PRK10490 715 TRL--VNNLLDMARIQsggfnlrkewltLEEVVGSALQMLEPGLSGHPINL--SLPEPLTlIHVDGPLFERVLINLLENA 790
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 497 IAYAGSNIQININCfREDENFYYFSFADTGIGVSPEHLNRLFERFYRVDKGRSrkLGGTGLGLAIVKNAVIIHGGNISAK 576
Cdd:PRK10490 791 VKYAGAQAEIGIDA-HVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKESA--IPGVGLGLAICRAIVEVHGGTIWAE 867
|
250
....*....|....*..
gi 495920141 577 NNQGGGLEFVFTLAKEK 593
Cdd:PRK10490 868 NRPEGGACFRVTLPLET 884
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
485-589 |
1.05e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 84.30 E-value: 1.05e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 485 LYSIFRNLMDNAIAYAGS--NIQININCfREDENFYYFSFADTGIGVSPEHLNRLFERFYRVDkGRSrKLGGTGLGLAIV 562
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPrrPPRIEVGA-EDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLH-SRE-EYEGTGVGLAIV 77
|
90 100
....*....|....*....|....*..
gi 495920141 563 KNAVIIHGGNISAKNNQGGGLEFVFTL 589
Cdd:cd16921 78 RKIIERHGGRIWLESEPGEGTTFYFTL 104
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
369-589 |
1.60e-19 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 91.20 E-value: 1.60e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 369 KRQLTQNIAHELKTPVSSIQGYLETivsNENiPREKINVFLERCYAQsnrLSRLLRDISVLTRMDEAASMIDMERVDISV 448
Cdd:PRK10604 212 KKQLIDGIAHELRTPLVRLRYRLEM---SDN-LSAAESQALNRDIGQ---LEALIEELLTYARLDRPQNELHLSEPDLPA 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 449 LVGNIINEVSLELDEKHITVinslkkSIQVKGNYS-----LLYSIFRNLMDNAIAYAGSNIQININcfrEDENFYYFSFA 523
Cdd:PRK10604 285 WLSTHLADIQAVTPEKTVRL------DTPHQGDYGaldmrLMERVLDNLLNNALRYAHSRVRVSLL---LDGNQACLIVE 355
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 495920141 524 DTGIGVSPEHLNRLFERFYRVDKGRSRKLGGTGLGLAIVKNAVIIHGGNISAKNNQGGGLEFVFTL 589
Cdd:PRK10604 356 DDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSW 421
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
491-584 |
8.64e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 81.73 E-value: 8.64e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 491 NLMDNAIAYAGSNIQININCfreDENFYYFSFADTGIGVSPEHLNRLFERFYRVDKgrSRKLGGTGLGLAIVKNAVIIHG 570
Cdd:cd16950 7 NLVDNALRYGGGWVEVSSDG---EGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDN--ARGTSGTGLGLAIVQRISDAHG 81
|
90
....*....|....
gi 495920141 571 GNISAKNNQGGGLE 584
Cdd:cd16950 82 GSLTLANRAGGGLC 95
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
225-591 |
1.65e-18 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 88.64 E-value: 1.65e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 225 NELGEISQhIIQIYKRLhETKEALYIEREKLITHLQISHEGLGVFTKDKKEILVNNLFTQYSNlISDSNL--ETTEEVFA 302
Cdd:COG5805 131 NGQAAILA-LRDITKKK-KIEEILQEQEERLQTLIENSPDLICVIDTDGRILFINESIERLFG-APREELigKNLLELLH 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 303 ISELKEIIHFINKNQQERSRGKGEKRMsvtINKNGRTFIVECII-------FQDASFEISINDVTQ----EEEQVRLKR- 370
Cdd:COG5805 208 PCDKEEFKERIESITEVWQEFIIEREI---ITKDGRIRYFEAVIvplidtdGSVKGILVILRDITEkkeaEELMARSEKl 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 371 ----QLTQNIAHELKTPVSSIQGYLETIVSNENIPREKINVFLErcyaQSNRLSRLLRDISVLTRMDEaasmIDMERVDI 446
Cdd:COG5805 285 siagQLAAGIAHEIRNPLTSIKGFLQLLQPGIEDKEEYFDIMLS----ELDRIESIISEFLALAKPQA----VNKEKENI 356
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 447 SVLVGNIIN--EVSLELDEKHItVINSLKKSIQVKGNYSLLYSIFRNLMDNAIAY--AGSNIQINIncfREDENFYYFSF 522
Cdd:COG5805 357 NELIQDVVTllETEAILHNIQI-RLELLDEDPFIYCDENQIKQVFINLIKNAIEAmpNGGTITIHT---EEEDNSVIIRV 432
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495920141 523 ADTGIGVSPEHLNRLFERFYrvdkgrSRKLGGTGLGLAIVKNAVIIHGGNISAKNNQGGGLEFVFTLAK 591
Cdd:COG5805 433 IDEGIGIPEERLKKLGEPFF------TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPL 495
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
358-589 |
8.37e-18 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 86.95 E-value: 8.37e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 358 DVTQEEE-QVRLKRQ--------LTQNIAHELKTPVSSIQGYLETIV--SNENIPREKINVFLErcyaQSNRLSRLLRDI 426
Cdd:PRK11360 370 DLTERKRlQRRVARQerlaalgeLVAGVAHEIRNPLTAIRGYVQIWRqqTSDPPSQEYLSVVLR----EVDRLNKVIDQL 445
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 427 SVLTRMDEAAsmidMERVDISVLVGNIINEVSLELDEKHITVINSLKKSI-QVKGNYSLLYSIFRNLMDNAIAYAGSNIQ 505
Cdd:PRK11360 446 LEFSRPRESQ----WQPVSLNALVEEVLQLFQTAGVQARVDFETELDNELpPIWADPELLKQVLLNILINAVQAISARGK 521
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 506 ININCFREDENFYYFSFADTGIGVSPEHLNRLFERFYrvdkgrSRKLGGTGLGLAIVKNAVIIHGGNISAKNNQGGGLEF 585
Cdd:PRK11360 522 IRIRTWQYSDGQVAVSIEDNGCGIDPELLKKIFDPFF------TTKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTF 595
|
....
gi 495920141 586 VFTL 589
Cdd:PRK11360 596 TLYL 599
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
370-583 |
8.48e-18 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 85.02 E-value: 8.48e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 370 RQLTQNIAHELKTPVSSIQGYLETIVSNENIprekinvfleRCYAQSNRLSRLLRDIS---VLTRMDEAASMIDMERVDi 446
Cdd:PRK10755 138 RLFTADVAHELRTPLAGIRLHLELLEKQHHI----------DVAPLIARLDQMMHTVEqllQLARAGQSFSSGHYQTVK- 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 447 svLVGNII----NEVSLELDEKHITVI-NSLKKSIQVKGNYSLLYSIFRNLMDNAIAYA--GSNIQININcfrEDENFYY 519
Cdd:PRK10755 207 --LLEDVIlpsqDELSEMLEQRQQTLLlPESAADITVQGDATLLRLLLRNLVENAHRYSpeGSTITIKLS---QEDGGAV 281
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 495920141 520 FSFADTGIGVSPEHLNRLFERFYRVDkgrsRKLGGTGLGLAIVKNAVIIHGGNISAKN-NQGGGL 583
Cdd:PRK10755 282 LAVEDEGPGIDESKCGELSKAFVRMD----SRYGGIGLGLSIVSRITQLHHGQFFLQNrQERSGT 342
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
488-585 |
2.69e-17 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 77.92 E-value: 2.69e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 488 IFRNLMDNAIAYAGSNIQININCFREDENFYYFSFADTGIGVSPEHLNRLFERFYRVDKGRSRKLGGTGLGLAIVKNAVI 567
Cdd:cd16925 8 VVLNLLSNAFKFTPDGGRIRCILEKFRLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLSIVKEFVE 87
|
90
....*....|....*...
gi 495920141 568 IHGGNISAKNNQGGGLEF 585
Cdd:cd16925 88 LHGGTVTVSDAPGGGALF 105
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
172-593 |
3.31e-17 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 83.74 E-value: 3.31e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 172 YLWFTIIVTLLLMIIFYKFTNKLGTSISQLREFAMRADRNEPIEMAMQSAFPHNELGEISQHIIQIYKRLHETKEALYIE 251
Cdd:COG3290 6 LLLLLLLILLILILILLLLLLIILLLILLLVLLLLLFLLFVIILLLLLLILLLILLLLLLLLLAALLLKLLEEIARLVEE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 252 REKLithLQISHEGLGVFTKDKKEILVNNLFTQYsnlisdsnLETTEEVFAISELKEIIHFINKNQQERSRGKGEKRMSV 331
Cdd:COG3290 86 REAV---LESIREGVIAVDRDGRITLINDAARRL--------LGLDAIGRPIDEVLAEVLETGERDEEILLNGRVLVVNR 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 332 TINKNGRTFIVECIIFQDasfeisINDVTQEEEQVRLKRQLTQNI---AHELKTPVSSIQGYLetivsneniprekinvf 408
Cdd:COG3290 155 VPIRDDGRVVGAVATFRD------RTELERLEEELEGVKELAEALraqRHDFRNHLHTISGLL----------------- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 409 lercyaQSNRLSRLLRDISVLTRMDEAASMIDMERVDISVLVGnIINEVSLELDEKHITVINSLKKSIQVKG-NYSLLYS 487
Cdd:COG3290 212 ------QLGEYDEALEYIDEISEELQELIDSLLSRIGNPVLAA-LLLGKAARARERGIDLTIDIDSDLPDLPlSDTDLVT 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 488 IFRNLMDNAIAYAGSN------IQINIncfREDENFYYFSFADTGIGVSPEHLNRLFERfyrvdkGRSRKLG-GTGLGLA 560
Cdd:COG3290 285 ILGNLLDNAIEAVEKLpeeerrVELSI---RDDGDELVIEVEDSGPGIPEELLEKIFER------GFSTKLGeGRGLGLA 355
|
410 420 430
....*....|....*....|....*....|...
gi 495920141 561 IVKNAVIIHGGNISAKNNQGGGLEFVFTLAKEK 593
Cdd:COG3290 356 LVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEG 388
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
490-589 |
7.88e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 76.31 E-value: 7.88e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 490 RNLMDNAIAYAGSNIQINincFREDENFYYFSFADTGIGVSPEHLNRLFERFYRVDKGRSRKLGGTGLGLAIVKNAVIIH 569
Cdd:cd16939 6 DNLLRNALRYAHRTVRIA---LLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVALWH 82
|
90 100
....*....|....*....|
gi 495920141 570 GGNISAKNNQGGGLEFVFTL 589
Cdd:cd16939 83 GGHVECDDSELGGACFRLTW 102
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
485-575 |
1.46e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 75.50 E-value: 1.46e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 485 LYSIFRNLMDNAIAYAGSNIQININCFREDENFYyFSFADTGIGVSPEHLNRLFERFYRVDKgrSRKLGGTGLGLAIVKN 564
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVN-IMFKNPSSHPLDFKLEKLFERFYRGDN--SRNTEGAGLGLSIAKA 77
|
90
....*....|.
gi 495920141 565 AVIIHGGNISA 575
Cdd:cd16923 78 IIELHGGSASA 88
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
481-587 |
4.28e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 74.42 E-value: 4.28e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 481 NYSLLYSIFRNLMDNAIAYA--GSNIQININCfreDENFYYFSFADTGIGVSPEHLNRLFERFYRVDKGRSRKlGGTGLG 558
Cdd:cd16975 1 DTLLLSRALINIISNACQYApeGGTVSISIYD---EEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSG-GHYGMG 76
|
90 100
....*....|....*....|....*....
gi 495920141 559 LAIVKNAVIIHGGNISAKNNQGGGLEFVF 587
Cdd:cd16975 77 LYIAKNLVEKHGGSLIIENSQKGGAEVTV 105
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
372-589 |
4.48e-15 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 77.90 E-value: 4.48e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 372 LTQNIAHELKTPVSSIQGYLETIvsNENIP-----REKINVFLErcyaQSNRLSRLLRDISVLTRmdeaASMIDMERVDI 446
Cdd:PRK10364 240 LAAGVAHEIRNPLSSIKGLAKYF--AERAPaggeaHQLAQVMAK----EADRLNRVVSELLELVK----PTHLALQAVDL 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 447 SVLVGNIINEVSLELDEKHITV---INSLKKSIQVKGNYslLYSIFRNLMDNAIAYAGSNIQININCFREDENFYyFSFA 523
Cdd:PRK10364 310 NDLINHSLQLVSQDANSREIQLrftANDTLPEIQADPDR--LTQVLLNLYLNAIQAIGQHGVISVTASESGAGVK-ISVT 386
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 495920141 524 DTGIGVSPEHLNRLFERFYrvdkgrSRKLGGTGLGLAIVKNAVIIHGGNISAKNNQGGGLEFVFTL 589
Cdd:PRK10364 387 DSGKGIAADQLEAIFTPYF------TTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWL 446
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
369-592 |
9.52e-15 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 77.85 E-value: 9.52e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 369 KRQLTQNIAHELKTPVSSIQGYLEtIVSNENIPREKINVFLERCYAQSNRLSRLLRDISVLTRMDEAASMIDMERVDISV 448
Cdd:PRK09959 712 KSQFLATMSHEIRTPISSIMGFLE-LLSGSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQWVDIPT 790
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 449 LVGNIINEVSLELDEKHITV--INSLKKSIQVKGNYSLLYSIFRNLMDNAIAYAGSN-IQININCFREDEN--FYYFSFA 523
Cdd:PRK09959 791 LVQNTCHSFGAIAASKSIALscSSTFPDHYLVKIDPQAFKQVLSNLLSNALKFTTEGaVKITTSLGHIDDNhaVIKMTIM 870
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495920141 524 DTGIGVSPEHLNRLFERFYRVDKGRSRKlgGTGLGLAIVKNAVIIHGGNISAKNNQGGGLEFVFTLAKE 592
Cdd:PRK09959 871 DSGSGLSQEEQQQLFKRYSQTSAGRQQT--GSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIPVE 937
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
372-583 |
2.00e-14 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 75.72 E-value: 2.00e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 372 LTQNIAHELKTPVSSIQGYLETIVSNENIPREKINVFLERCYAQSNRLsrllrdISVLtRMDEAASMidmERVDISVLVG 451
Cdd:PRK09467 232 LMAGVSHDLRTPLTRIRLATEMMSEEDGYLAESINKDIEECNAIIEQF------IDYL-RTGQEMPM---EMADLNALLG 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 452 NIIN-------EVSLELDEKHITV-INSLkksiqvkgnysllySIFR---NLMDNAIAYAGSNIQININcfrEDENFYYF 520
Cdd:PRK09467 302 EVIAaesgyerEIETALQPGPIEVpMNPI--------------AIKRalaNLVVNAARYGNGWIKVSSG---TEGKRAWF 364
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 495920141 521 SFADTGIGVSPEHLNRLFERFYRVDKGRSRKlgGTGLGLAIVKNAVIIHGGNISAKNNQGGGL 583
Cdd:PRK09467 365 QVEDDGPGIPPEQLKHLFQPFTRGDSARGSS--GTGLGLAIVKRIVDQHNGKVELGNSEEGGL 425
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
469-574 |
6.83e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 68.69 E-value: 6.83e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 469 INSLKKSIQVKGNYSLLYSIFRNLMDNAIAYAGSNIQININcFREDENFYYFSFADTGIGVSPEHLNRLFERFYRVDKGR 548
Cdd:cd16947 5 INIPDRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMT-LREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSR 83
|
90 100
....*....|....*....|....*.
gi 495920141 549 SRKLGGTGLGLAIVKNAVIIHGGNIS 574
Cdd:cd16947 84 NSAKQGNGLGLTITKRLAESMGGSIY 109
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
370-589 |
6.09e-13 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 71.70 E-value: 6.09e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 370 RQLTQNIAHELKTPVSSIQGYLETIVSNENIPREKinVFLERCYAQSNRLSRLLRDISVLTRMDEAASMIDMERVDISVL 449
Cdd:TIGR03785 486 ENMSSRLSHELRTPVAVVRSSLENLELQALEQEKQ--KYLERAREGTERLSMILNNMSEATRLEQAIQSAEVEDFDLSEV 563
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 450 VGNIINEVSLeLDEKHITVINSLKKSIQVKGNYSLLYSIFRNLMDNAIAYAGSNIQINInCFREDENFYYFSFADTGIGV 529
Cdd:TIGR03785 564 LSGCMQGYQM-TYPPQRFELNIPETPLVMRGSPELIAQMLDKLVDNAREFSPEDGLIEV-GLSQNKSHALLTVSNEGPPL 641
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 495920141 530 sPEHLN-RLFERFYRVDKGRSRKLGGTGLGLAIVKNAVIIHGGNISAKNN-QGGGLEFVFTL 589
Cdd:TIGR03785 642 -PEDMGeQLFDSMVSVRDQGAQDQPHLGLGLYIVRLIADFHQGRIQAENRqQNDGVVFRISL 702
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
491-589 |
7.84e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 64.73 E-value: 7.84e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 491 NLMDNAI-AYAGSNI---QININCFREDENFYYFSFADTGIGVSPEHLNRLFERFYrvdkgrSRKLGGTGLGLAIVKNAV 566
Cdd:cd16920 7 NLVRNGIeAMSEGGCerrELTIRTSPADDRAVTISVKDTGPGIAEEVAGQLFDPFY------TTKSEGLGMGLSICRSII 80
|
90 100
....*....|....*....|...
gi 495920141 567 IIHGGNISAKNNQGGGLEFVFTL 589
Cdd:cd16920 81 EAHGGRLSVESPAGGGATFQFTL 103
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
463-589 |
2.10e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 64.58 E-value: 2.10e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 463 EKHITVINSLKKSIQVKGNYSLLYSIFRNLMDNAIAYAGSNIQIninCFREDENFYYFSFADTGIGVSPEHLNRLFERFY 542
Cdd:cd16954 16 RKGVSISLDISPELRFPGERNDLMELLGNLLDNACKWCLEFVEV---TARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQ 92
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 495920141 543 RVDKGRSrklgGTGLGLAIVKNAVIIHGGNISAKNNQGGGLEFVFTL 589
Cdd:cd16954 93 RLDEQRP----GQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
364-589 |
2.18e-12 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 68.82 E-value: 2.18e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 364 EQVRLKRQLTQNIAHELKTPVSSIQGYLETIVSNENIP-REKINVFLERCYAQSNR----LSRLLRDISVLTRMDEAASM 438
Cdd:PRK09303 146 EQLKFKDRVLAMLAHDLRTPLTAASLALETLELGQIDEdTELKPALIEQLQDQARRqleeIERLITDLLEVGRTRWEALR 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 439 IDMERVDISVLVGNIINEVSLELDEKHITVINSLKKSI-QVKGNYSLLYSIFRNLMDNAIAYAGSNIQININCFREDENF 517
Cdd:PRK09303 226 FNPQKLDLGSLCQEVILELEKRWLAKSLEIQTDIPSDLpSVYADQERIRQVLLNLLDNAIKYTPEGGTITLSMLHRTTQK 305
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 495920141 518 YYFSFADTGIGVSPEHLNRLFERFYRVDkgRSRKLGGTGLGLAIVKNAVIIHGGNISAKNNQGGGLEFVFTL 589
Cdd:PRK09303 306 VQVSICDTGPGIPEEEQERIFEDRVRLP--RDEGTEGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHFTL 375
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
484-585 |
3.82e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 62.86 E-value: 3.82e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 484 LLYSIFRNLMDNAIAYAGSNIQININCFREDENFYYFSFaDTGIGVSPEHLNRLFERFYRVDKGRSRKlGGTGLGLAIVK 563
Cdd:cd16945 4 LLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVF-DEGSGIPDYALNRVFERFYSLPRPHSGQ-KSTGLGLAFVQ 81
|
90 100
....*....|....*....|..
gi 495920141 564 NAVIIHGGNISAKNNQGGGLEF 585
Cdd:cd16945 82 EVAQLHGGRITLRNRPDGVLAF 103
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
485-589 |
6.91e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 62.30 E-value: 6.91e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 485 LYSIFRNLMDNAI-AYAGSNIQIN-INCFREDEN-FYYFSFADTGIGVSPEHLNRLFERFYRvdkgrSRKLGGTGLGLAI 561
Cdd:cd16915 1 LITIVGNLIDNALdALAATGAPNKqVEVFLRDEGdDLVIEVRDTGPGIAPELRDKVFERGVS-----TKGQGERGIGLAL 75
|
90 100
....*....|....*....|....*...
gi 495920141 562 VKNAVIIHGGNISAKNNQGGGLEFVFTL 589
Cdd:cd16915 76 VRQSVERLGGSITVESEPGGGTTFSIRI 103
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
485-590 |
9.11e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 61.92 E-value: 9.11e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 485 LYSIFRNLMDNAIAYAGSNIQININCFrEDENFYYFSFADTGIGVSPEHLNRLFERFYRVDKGRsRKLGGTGLGLAIVKN 564
Cdd:cd16948 6 LSFIIGQIVSNALKYSKQGGKIEIYSE-TNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGR-NFQESTGMGLYLVKK 83
|
90 100
....*....|....*....|....*.
gi 495920141 565 AVIIHGGNISAKNNQGGGLEFVFTLA 590
Cdd:cd16948 84 LCDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
483-589 |
4.66e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 59.74 E-value: 4.66e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 483 SLLYSIFRNLMDNAIAYAGSNIQININCFREDENFYyFSFADTGIGVSPEHLNRLFERFYRvdkgrSRKLG-GTGLGLAI 561
Cdd:cd16943 2 SQLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVL-IEVEDTGSGIDPEILGRIFDPFFT-----TKPVGeGTGLGLSL 75
|
90 100
....*....|....*....|....*...
gi 495920141 562 VKNAVIIHGGNISAKNNQGGGLEFVFTL 589
Cdd:cd16943 76 SYRIIQKHGGTIRVASVPGGGTRFTIIL 103
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
369-434 |
7.08e-11 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 57.99 E-value: 7.08e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 495920141 369 KRQLTQNIAHELKTPVSSIQGYLETIvsNENIPREKINVFLERCYAQSNRLSRLLRDISVLTRMDE 434
Cdd:pfam00512 2 KSEFLANLSHELRTPLTAIRGYLELL--RDEKLDEEQREYLETILRSAERLLRLINDLLDLSRIEA 65
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
367-431 |
1.55e-10 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 56.84 E-value: 1.55e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 495920141 367 RLKRQLTQNIAHELKTPVSSIQGYLETIVSNENIPrEKINVFLERCYAQSNRLSRLLRDISVLTR 431
Cdd:cd00082 2 QAKGEFLANVSHELRTPLTAIRGALELLEEELLDD-EEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
491-589 |
1.87e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 57.85 E-value: 1.87e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 491 NLMDNAIAYAGS--NIQININCFREDENfYYFSFADTGIGVSPEHLNRLFERFYRvdkgrSRKLG-GTGLGLAIVKNAVI 567
Cdd:cd16976 7 NLLQNALDAMGKveNPRIRIAARRLGGR-LVLVVRDNGPGIAEEHLSRVFDPFFT-----TKPVGkGTGLGLSISYGIVE 80
|
90 100
....*....|....*....|..
gi 495920141 568 IHGGNISAKNNQGGGLEFVFTL 589
Cdd:cd16976 81 EHGGRLSVANEEGAGARFTFDL 102
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
369-434 |
1.94e-10 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 56.81 E-value: 1.94e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 495920141 369 KRQLTQNIAHELKTPVSSIQGYLETIVSNENIPREKinVFLERCYAQSNRLSRLLRDISVLTRMDE 434
Cdd:smart00388 2 KREFLANLSHELRTPLTAIRGYLELLLDTELSEEQR--EYLETILREAERLLRLINDLLDLSRIEA 65
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
485-589 |
2.77e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 57.97 E-value: 2.77e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 485 LYSIFRNLMDNAIAYA-GSNIQININCFREDeNFYYFSFADTGIGVSPEHLNRLFERFYrVDKGRSRKLG-GTGLGLAIV 562
Cdd:cd16953 1 LGQVLRNLIGNAISFSpPDTGRITVSAMPTG-KMVTISVEDEGPGIPQEKLESIFDRFY-TERPANEAFGqHSGLGLSIS 78
|
90 100 110
....*....|....*....|....*....|.
gi 495920141 563 KNAVIIHGGNISAKN----NQGGGLEFVFTL 589
Cdd:cd16953 79 RQIIEAHGGISVAENhnqpGQVIGARFTVQL 109
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
491-586 |
7.06e-10 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 61.91 E-value: 7.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 491 NLMDNAIAYAGS-NIQININCfreDENFYYFSFADTGIGVSPEHLNRLFERFYRVDKGRSRKLGGTGLGLAIVKNAVIIH 569
Cdd:PRK10841 569 NLLSNAIKFTDTgCIVLHVRV---DGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMM 645
|
90
....*....|....*..
gi 495920141 570 GGNISAKNNQGGGLEFV 586
Cdd:PRK10841 646 DGDISVDSEPGMGSQFT 662
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
488-589 |
1.39e-09 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 61.02 E-value: 1.39e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 488 IFRNLMDNAIAYAGS-NIQININCFREDENFYY--FSFADTGIGVSPEHLNRLFERFYRVDKGRSRKLGGTGLGLAIVKN 564
Cdd:PRK11107 412 IITNLVGNAIKFTESgNIDILVELRALSNTKVQleVQIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQK 491
|
90 100
....*....|....*....|....*
gi 495920141 565 AVIIHGGNISAKNNQGGGLEFVFTL 589
Cdd:PRK11107 492 LVNEMGGDISFHSQPNRGSTFWFHL 516
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
356-589 |
1.59e-09 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 60.81 E-value: 1.59e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 356 INDVTQEEEQV--RLKRQLTqNIAHELKTPVSSIQGYLETIVSNENIPREK----------------INVFLERCYAQSN 417
Cdd:PRK15347 384 LAEAKQRAEQAnkRKSEHLT-TISHEIRTPLNGVLGALELLQNTPLTAEQMdladtarqctlsllaiINNLLDFSRIESG 462
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 418 RLSRLLRDISVLTRMDEAASMIDM----ERVDISVLVGNiinEVSLELDekhitvINSLKksiqvkgnyslLYSIFRNLM 493
Cdd:PRK15347 463 QMTLSLEETALLPLLDQAMLTIQGpaqsKSLTLRTFVGA---HVPLYLH------LDSLR-----------LRQILVNLL 522
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 494 DNAIAYAGSNiQININCFREDENFYyFSFADTGIGVSPEHLNRLFERFYRVDKgrsrKLGGTGLGLAIVKNAVIIHGGNI 573
Cdd:PRK15347 523 GNAVKFTETG-GIRLRVKRHEQQLC-FTVEDTGCGIDIQQQQQIFTPFYQADT----HSQGTGLGLTIASSLAKMMGGEL 596
|
250
....*....|....*.
gi 495920141 574 SAKNNQGGGLEFVFTL 589
Cdd:PRK15347 597 TLFSTPGVGSCFSLVL 612
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
362-589 |
2.20e-09 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 60.46 E-value: 2.20e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 362 EEEQVRLKRQLTQ------------NIAHELKTPVSSIQGYLEtIVSNENIPREKINVFLERCYAQSNRLSRLLRDISVL 429
Cdd:PRK13837 431 ETERDALERRLEHarrleavgtlasGIAHNFNNILGAILGYAE-MALNKLARHSRAARYIDEIISAGARARLIIDQILAF 509
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 430 TRMDEAASmidmERVDISVLVGNIINEVSLELDEkHITVINSL-KKSIQVKGNYSLLYSIFRNLMDNAIAYAGSNIQINI 508
Cdd:PRK13837 510 GRKGERNT----KPFDLSELVTEIAPLLRVSLPP-GVELDFDQdQEPAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDI 584
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 509 NCFRED--------------ENFYYFSFADTGIGVSPEHLNRLFERFYRVdkgRSrklGGTGLGLAIVKNAVIIHGGNIS 574
Cdd:PRK13837 585 SLSRAKlrapkvlshgvlppGRYVLLRVSDTGAGIDEAVLPHIFEPFFTT---RA---GGTGLGLATVHGIVSAHAGYID 658
|
250
....*....|....*
gi 495920141 575 AKNNQGGGLEFVFTL 589
Cdd:PRK13837 659 VQSTVGRGTRFDVYL 673
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
376-589 |
6.84e-09 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 58.80 E-value: 6.84e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 376 IAHELKTPVSSIQGyLETIVSNENIPREKINvFLERCYAQSNRLSRLLRDISVLTRMDEAASMIDMERVDISVLVGNIIN 455
Cdd:PRK11091 290 ISHELRTPLNGIVG-LSRILLDTELTAEQRK-YLKTIHVSAITLGNIFNDIIDMDKMERRKLQLDNQPIDFTDFLADLEN 367
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 456 EVSLELDEK----HITVINSLKKSIQVKGnySLLYSIFRNLMDNAIAYAGSNiQININCFREDENFYYFSFADTGIGVSP 531
Cdd:PRK11091 368 LSGLQAEQKglrfDLEPLLPLPHKVITDG--TRLRQILWNLISNAVKFTQQG-GVTVRVRYEEGDMLTFEVEDSGIGIPE 444
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 495920141 532 EHLNRLFERFYRVDKGRSRKLG-GTGLGLAIVKNAVIIHGGNISAKNNQGGGLEFVFTL 589
Cdd:PRK11091 445 DELDKIFAMYYQVKDSHGGKPAtGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTI 503
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
485-582 |
7.97e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 50.61 E-value: 7.97e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 485 LYSIFRNLMDNAIAYAGSNIQININCFREDENFYYFSFADTGIGVSPEHLNRLFERfYRVDKGRsrklgGTGLGLAIVKN 564
Cdd:cd16944 9 LTNILKNAAEAIEGRPSDVGEVRIRVEADQDGRIVLIVCDNGKGFPREMRHRATEP-YVTTRPK-----GTGLGLAIVKK 82
|
90
....*....|....*...
gi 495920141 565 AVIIHGGNISAKNNQGGG 582
Cdd:cd16944 83 IMEEHGGRISLSNREAGG 100
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
361-589 |
2.28e-06 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 50.67 E-value: 2.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 361 QEEEQVRLKRQLTQNIAHELKTPVSSIQGYLETIVSNENIPREKinVFLERCYAQSNRLSRLLRDIsvltrMDEAASMID 440
Cdd:PRK11466 436 EAEKASQAKSAFLAAMSHEIRTPLYGILGTAQLLADNPALNAQR--DDLRAITDSGESLLTILNDI-----LDYSAIEAG 508
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 441 MERVDIS-------VLVGNIINEVSLELDEKHITVINSLKKSI--QVKGNYSLLYSIFRNLMDNAIAYAGSNIqININCF 511
Cdd:PRK11466 509 GKNVSVSdepfeprPLLESTLQLMSGRVKGRPIRLATDIADDLptALMGDPRRIRQVITNLLSNALRFTDEGS-IVLRSR 587
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 495920141 512 REDENfYYFSFADTGIGVSPEHLNRLFERFYRVdkgrSRKLGGTGLGLAIVKNAVIIHGGNISAKNNQGGGLEFVFTL 589
Cdd:PRK11466 588 TDGEQ-WLVEVEDSGCGIDPAKLAEIFQPFVQV----SGKRGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRL 660
|
|
| ArsS_fam_HK |
NF038389 |
ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase ... |
375-570 |
3.09e-06 |
|
ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase participating in a two-component system that controls the response to acid conditiions encountered during the process of gastric colonization. This HMM identified ArsS itself but also a broader collection of apparent orthologs from closely related non-gastric colonizers such as Helicobacter hepaticus, Campylobacter jejuni and Wolinella succinogenes. See BlastRule NBR014349 for specific identification of ArsS itself, distinguished by a signature His residue that becomes protonated at low pH.
Pssm-ID: 468500 [Multi-domain] Cd Length: 402 Bit Score: 49.84 E-value: 3.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 375 NIAHELKTPVSSIQGYLETIVSNENipREK-INVFlercyaqsNRLSRLlrdISVLTRMDEAAS---MIDMERVDISVLV 450
Cdd:NF038389 212 NIMHELKTPITKGRIVAEMLEDEKQ--KERlISIF--------ERLESL---INEFAKIEQLTSknyKLNKKEYRLSDII 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 451 GNIINevSLELDEKHITVINSLKKSIqVKGNYSLLYSIFRNLMDNAIAYAgSNIQININCfreDENFYYFSfadtGIGVS 530
Cdd:NF038389 279 DEAID--MLMIDDSSVIIKVSLEDFK-LNVDFELFSLAIKNLIDNAIKYS-PDKKVTIEI---KGDKIEFK----NKGEP 347
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 495920141 531 PEH-LNRLFERFYrvdKGRSRKLGGTGLGLAIVKNAVIIHG 570
Cdd:NF038389 348 LEEpLEYYFEPFF---KGNEKSKSGFGLGLYIVKNILKAHG 385
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
485-574 |
3.75e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 45.85 E-value: 3.75e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 485 LYSIFRNLMDNAI-AYAGSNIQININCFREdenfYYFSFA-------------DTGIGVSPEHLNRLFERFYrvdkgrSR 550
Cdd:cd16918 1 LIQVFLNLVRNAAqALAGSGGEIILRTRTQ----RQVTLGhprhrlalrvsviDNGPGIPPDLQDTIFYPMV------SG 70
|
90 100
....*....|....*....|....
gi 495920141 551 KLGGTGLGLAIVKNAVIIHGGNIS 574
Cdd:cd16918 71 RENGTGLGLAIAQNIVSQHGGVIE 94
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
516-582 |
1.79e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 44.29 E-value: 1.79e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 495920141 516 NFYYFSFADTGIGVSPEHLNRLFERFYRVdKGRSRklgGTGLGLAIVKNAVIIHGGNISAKNNQGGG 582
Cdd:cd16919 46 NYVCLEVSDTGSGMPAEVLRRAFEPFFTT-KEVGK---GTGLGLSMVYGFVKQSGGHLRIYSEPGVG 108
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
346-537 |
3.11e-05 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 47.23 E-value: 3.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 346 IFQDASFEISINDVTQE-----EEQVRLKRQLTQNIAHELKTPVSSIQGYLETI--VSNENIPREKINVFLErcyaQSNR 418
Cdd:PRK10618 422 LLRDQDREVLVNKKLQQaqreyEKNQQARKAFLQNIGDELKQPLQSLAQLAAQLrqTSDEEQQQPELDQLAE----QSDV 497
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 419 LSRLLRDISVLTRMDEAASMIDMERVDISVLVGNIINEVSLELDEKHITVI--NSLKKSIQVKGNYSLLYSIFRNLMDNA 496
Cdd:PRK10618 498 LVRLVDNIQLLNMLETQDWKPEQELFSLQDLIDEVLPEVLPAIKRKGLQLLihNHLKAEQLRIGDRDALRKILLLLLNYA 577
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 495920141 497 I---AYAgsNIQININCFREDENFYYFSFADTGIGVSPEHLNRL 537
Cdd:PRK10618 578 ItttAYG--KITLEVDQDESSPDRLTIRILDTGAGVSIKELDNL 619
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
375-587 |
9.28e-05 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 45.39 E-value: 9.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 375 NIAHELKTPVSSIQGYLETIVSNENIPREKIN-VFLErcyaQSNRLSRLLRdiSVLTRmdeaASMidmeRVDISVLVGNI 453
Cdd:PRK10815 272 DLTHSLKTPLAVLQSTLRSLRSGKQMSVEQAEpIMLE----QISRISQQIG--YYLHR----ASM----RSEHNLLSREL 337
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 454 iNEVSLELDekhiTVINSLKKSIQVKG-NYSLLYS--------------IFRNLMDNAIAYAGSNIQINIncfREDENFY 518
Cdd:PRK10815 338 -HSVAPLLD----NLTSALNKVYQRKGvNITLDISpeitfvgekndfmeVMGNVLDNACKYCLEFVEISA---RQTDEHL 409
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 495920141 519 YFSFADTGIGVSPEHLNRLFERFYRVDKGRSrklgGTGLGLAIVKNAVIIHGGNISAKNNQGGG--LEFVF 587
Cdd:PRK10815 410 HIVVEDDGPGIPESKRELIFDRGQRADTLRP----GQGLGLSVAREITEQYEGKISAGDSPLGGarMEVIF 476
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
485-585 |
6.40e-04 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 42.59 E-value: 6.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 485 LYSIFRNLMDNAIAYAGSNIQININC-FREDENFYYFSFADTGIGVSPEHLNRLFErfyrvdKGRSRKLGGTGLGLAIVK 563
Cdd:PRK11086 434 LITILGNLIENALEAVGGEEGGEISVsLHYRNGWLHCEVSDDGPGIAPDEIDAIFD------KGYSTKGSNRGVGLYLVK 507
|
90 100
....*....|....*....|..
gi 495920141 564 NAVIIHGGNISAKNNQGGGLEF 585
Cdd:PRK11086 508 QSVENLGGSIAVESEPGVGTQF 529
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
357-573 |
6.99e-04 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 42.75 E-value: 6.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 357 NDVTQEEEQVRLKRQLTQnIAHELKTPVSSIQGYLETI-VSNENIPREKINVFLERCYAQSNRLSRLLRDISVLTRMDEA 435
Cdd:COG4192 422 DELIQAAKMAVVGQTMTS-LAHELNQPLNAMSMYLFSAkKALEQENYAQLPTSLDKIEGLIERMDKIIKSLRQFSRKSDT 500
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 436 asmiDMERVDISVLVgniinEVSLELDE---KHITVINSLKKSIQVKGNYSLLYSIFRNLMDNAIAYAGSNIQININCFR 512
Cdd:COG4192 501 ----PLQPVDLRQVI-----EQAWELVEsraKPQQITLHIPDDLMVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLS 571
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 495920141 513 EDENFYyFSFADTGIGVSPehLNRLFERFYrvdkgrSRKLGGTGLGLAIVKNAVIIHGGNI 573
Cdd:COG4192 572 NAENLR-VAISDNGNGWPL--VDKLFTPFT------TTKEVGLGLGLSICRSIMQQFGGDL 623
|
|
| HATPase_AgrC-ComD-like |
cd16935 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
453-578 |
3.98e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.
Pssm-ID: 340412 [Multi-domain] Cd Length: 134 Bit Score: 37.94 E-value: 3.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 453 IINEVSLELDEKHITVINSLKKSIQVKGNYSLLYSIFRNLMDNAI----AYAGSNIQINInCFREDENFYYFSFADTgig 528
Cdd:cd16935 5 LLSEKLELAREKGIEFTIEIDIPILLPISPLDLCIIFGNLLDNAIeacaKIDKENRFIHL-KIRQKKGFLIISIENS--- 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 495920141 529 vSPEHLNRLFERFYRVDKGRSRklggtGLGLAIVKNAVIIHGGNISAKNN 578
Cdd:cd16935 81 -YEGELKKKNGLFLSTKKDKNH-----GIGLKSIREIVKKYNGNLSIEYE 124
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
360-589 |
7.15e-03 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 38.45 E-value: 7.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 360 TQEEEQVRLKRQLTQNIAHELktpvSSIQGYLETIVSNENIPREKINVFLERCYAQSNRLSRLLRDIS-VLtrMDEAASM 438
Cdd:COG4585 49 AREEERRRIARELHDGVGQSL----SAIKLQLEAARRLLDADPEAAREELEEIRELAREALAELRRLVrGL--RPPALDD 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 439 IDMERvDISVLVGNIINEVSLELDEKHITVINSLKKSIQVkgnysLLYSIFRNLMDNAIAYAG-SNIQINIncfREDENF 517
Cdd:COG4585 123 LGLAA-ALEELAERLLRAAGIRVELDVDGDPDRLPPEVEL-----ALYRIVQEALTNALKHAGaTRVTVTL---EVDDGE 193
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 495920141 518 YYFSFADTGIGVSPEhlnrlferfyrvdkgrsrKLGGTGLGLAIVKNAVIIHGGNISAKNNQGGGLEFVFTL 589
Cdd:COG4585 194 LTLTVRDDGVGFDPE------------------AAPGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATL 247
|
|
| HATPase_c_5 |
pfam14501 |
GHKL domain; This family represents the structurally related ATPase domains of histidine ... |
485-580 |
9.61e-03 |
|
GHKL domain; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 433996 [Multi-domain] Cd Length: 102 Bit Score: 36.04 E-value: 9.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495920141 485 LYSIFRNLMDNAI---AYAGSNIQINInCFREDENFYYFSFADTGIGVSPEhLNRLFErfyrvdkgRSRKLGGTGLGLAI 561
Cdd:pfam14501 6 LCVIFGNLLDNAIeacSKIDDNRFIRL-KIREKQNFLIIRIENTYEGELKF-EGKLPS--------TKTKGDGHGIGLKS 75
|
90
....*....|....*....
gi 495920141 562 VKNAVIIHGGNISAKNNQG 580
Cdd:pfam14501 76 IRRIVKKYGGNLSTEIENG 94
|
|
| |
