NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|495778038|ref|WP_008502617|]
View 

MULTISPECIES: YfcZ/YiiS family protein [Enterobacter]

Protein Classification

YfcZ/YiiS family protein( domain architecture ID 10007842)

YfcZ/YiiS family protein is a DUF406 domain-containing protein; similar to Vibrio cholerae protein VC_A0919

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
YfcZ COG3691
Uncharacterized conserved protein YfcZ, UPF0381/DUF406 family [Function unknown];
1-94 6.04e-49

Uncharacterized conserved protein YfcZ, UPF0381/DUF406 family [Function unknown];


:

Pssm-ID: 442906  Cd Length: 98  Bit Score: 150.12  E-value: 6.04e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778038  1 MSKCSADETPVCCCMDVGTIMDNSDCTASYSRVFTNRAEAEETLAALSKRARDVESEPCEIKSTFTEVEGGVKLDIDFVF 80
Cdd:COG3691   5 IKKCKAEETAACCCVDVGTIIDNSDCTASFEAVYASEAEAEAALAALTEKARAVESEPCEISSEITPVEDGVLLKADFTF 84

                        90
                ....*....|....
gi 495778038 81 ACEAETLIFQLGLR 94
Cdd:COG3691  85 SCQAETLIFQLGLR 98
 
Name Accession Description Interval E-value
YfcZ COG3691
Uncharacterized conserved protein YfcZ, UPF0381/DUF406 family [Function unknown];
1-94 6.04e-49

Uncharacterized conserved protein YfcZ, UPF0381/DUF406 family [Function unknown];


Pssm-ID: 442906  Cd Length: 98  Bit Score: 150.12  E-value: 6.04e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778038  1 MSKCSADETPVCCCMDVGTIMDNSDCTASYSRVFTNRAEAEETLAALSKRARDVESEPCEIKSTFTEVEGGVKLDIDFVF 80
Cdd:COG3691   5 IKKCKAEETAACCCVDVGTIIDNSDCTASFEAVYASEAEAEAALAALTEKARAVESEPCEISSEITPVEDGVLLKADFTF 84

                        90
                ....*....|....
gi 495778038 81 ACEAETLIFQLGLR 94
Cdd:COG3691  85 SCQAETLIFQLGLR 98
TIGR00743 TIGR00743
conserved hypothetical protein; These small proteins are approximately 100 amino acids in ...
 1-94 1.45e-44

conserved hypothetical protein; These small proteins are approximately 100 amino acids in length and appear to be found only in gamma proteobacteria. The function of this protein family is unknown. [Hypothetical proteins, Conserved]


Pssm-ID: 273245  Cd Length: 95  Bit Score: 138.83  E-value: 1.45e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778038   1 MSKCSADETPVCCCMDVGTIMDNSDCTASYSRVFTNRAEAEETLAALSKRARDVESEPCEIKSTFTEVEGGVKLDIDFVF 80
Cdd:TIGR00743  2 IQKCKAIETVGCNCFDVGTIIDNSDCSQVISRFYATEAEAEEALAFLTEKARDTESEPCEIQSEITKVEDGVLLDADFTF 81

                         90
                 ....*....|....
gi 495778038  81 ACEAETLIFQLGLR 94
Cdd:TIGR00743 82 SCQAEMVIFELRLR 95
DUF406 pfam04175
Protein of unknown function (DUF406); Members of this family appear to be found only in gamma ...
 14-94 2.95e-37

Protein of unknown function (DUF406); Members of this family appear to be found only in gamma proteobacteria. The function of this protein family is undetermined. Solution of the structures of the two members of this family investigated bear some resemblance to that of the single domain enzyme pterin-4a-carbinolamine dehydratase, PDC. Although the residues of PCDs involved in binding of metabolite are not conserved in the two structures under study, they do correspond to a surface-region structurally aligned with residues that are highly conserved, eg Glu 89, suggesting that this region is also involved in binding of a ligand, thereby possibly constituting a catalytic site of a yet uncharacterized enzyme specific for gamma proteobacteria.


Pssm-ID: 427760  Cd Length: 81  Bit Score: 120.05  E-value: 2.95e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778038  14 CMDVGTIMDNSDCTASYSRVFTNRAEAEETLAALSKRARDVESEPCEIKSTFTEVEGGVKLDIDFVFACEAETLIFQLGL 93
Cdd:pfam04175  1 CVDVGTIIDNGDCVAEFSIVYASEAEAEAALAKLTEKAKAVESEPCEISSEITEVEDGVELDARFTFSCQAEKLIFELGL 80


                 .
gi 495778038  94 R 94
Cdd:pfam04175 81 R 81
PRK09981 PRK09981
DUF406 domain-containing protein;
13-94 2.42e-22

DUF406 domain-containing protein;


Pssm-ID: 182180  Cd Length: 99  Bit Score: 83.03  E-value: 2.42e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778038 13 CCMDVGTIMDNSDCTASYSRVFTNRAEAEETLAALSKRARDV--ESEPCEIKSTFTEVEGGVKLDIDFVFACEAETLIFQ 90
Cdd:PRK09981 13 CAIDIGTVIDNDNCTSKFSRFFATREEAESFMTKLKELAAAAssADEGASVAYKIKDLEGQVELDAAFTFSCQAEMIIFE 92


                ....
gi 495778038 91 LGLR 94
Cdd:PRK09981 93 LSLR 96
 
Name Accession Description Interval E-value
YfcZ COG3691
Uncharacterized conserved protein YfcZ, UPF0381/DUF406 family [Function unknown];
1-94 6.04e-49

Uncharacterized conserved protein YfcZ, UPF0381/DUF406 family [Function unknown];


Pssm-ID: 442906  Cd Length: 98  Bit Score: 150.12  E-value: 6.04e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778038  1 MSKCSADETPVCCCMDVGTIMDNSDCTASYSRVFTNRAEAEETLAALSKRARDVESEPCEIKSTFTEVEGGVKLDIDFVF 80
Cdd:COG3691   5 IKKCKAEETAACCCVDVGTIIDNSDCTASFEAVYASEAEAEAALAALTEKARAVESEPCEISSEITPVEDGVLLKADFTF 84

                        90
                ....*....|....
gi 495778038 81 ACEAETLIFQLGLR 94
Cdd:COG3691  85 SCQAETLIFQLGLR 98
TIGR00743 TIGR00743
conserved hypothetical protein; These small proteins are approximately 100 amino acids in ...
 1-94 1.45e-44

conserved hypothetical protein; These small proteins are approximately 100 amino acids in length and appear to be found only in gamma proteobacteria. The function of this protein family is unknown. [Hypothetical proteins, Conserved]


Pssm-ID: 273245  Cd Length: 95  Bit Score: 138.83  E-value: 1.45e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778038   1 MSKCSADETPVCCCMDVGTIMDNSDCTASYSRVFTNRAEAEETLAALSKRARDVESEPCEIKSTFTEVEGGVKLDIDFVF 80
Cdd:TIGR00743  2 IQKCKAIETVGCNCFDVGTIIDNSDCSQVISRFYATEAEAEEALAFLTEKARDTESEPCEIQSEITKVEDGVLLDADFTF 81

                         90
                 ....*....|....
gi 495778038  81 ACEAETLIFQLGLR 94
Cdd:TIGR00743 82 SCQAEMVIFELRLR 95
DUF406 pfam04175
Protein of unknown function (DUF406); Members of this family appear to be found only in gamma ...
 14-94 2.95e-37

Protein of unknown function (DUF406); Members of this family appear to be found only in gamma proteobacteria. The function of this protein family is undetermined. Solution of the structures of the two members of this family investigated bear some resemblance to that of the single domain enzyme pterin-4a-carbinolamine dehydratase, PDC. Although the residues of PCDs involved in binding of metabolite are not conserved in the two structures under study, they do correspond to a surface-region structurally aligned with residues that are highly conserved, eg Glu 89, suggesting that this region is also involved in binding of a ligand, thereby possibly constituting a catalytic site of a yet uncharacterized enzyme specific for gamma proteobacteria.


Pssm-ID: 427760  Cd Length: 81  Bit Score: 120.05  E-value: 2.95e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778038  14 CMDVGTIMDNSDCTASYSRVFTNRAEAEETLAALSKRARDVESEPCEIKSTFTEVEGGVKLDIDFVFACEAETLIFQLGL 93
Cdd:pfam04175  1 CVDVGTIIDNGDCVAEFSIVYASEAEAEAALAKLTEKAKAVESEPCEISSEITEVEDGVELDARFTFSCQAEKLIFELGL 80


                 .
gi 495778038  94 R 94
Cdd:pfam04175 81 R 81
PRK09981 PRK09981
DUF406 domain-containing protein;
13-94 2.42e-22

DUF406 domain-containing protein;


Pssm-ID: 182180  Cd Length: 99  Bit Score: 83.03  E-value: 2.42e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495778038 13 CCMDVGTIMDNSDCTASYSRVFTNRAEAEETLAALSKRARDV--ESEPCEIKSTFTEVEGGVKLDIDFVFACEAETLIFQ 90
Cdd:PRK09981 13 CAIDIGTVIDNDNCTSKFSRFFATREEAESFMTKLKELAAAAssADEGASVAYKIKDLEGQVELDAAFTFSCQAEMIIFE 92


                ....
gi 495778038 91 LGLR 94
Cdd:PRK09981 93 LSLR 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH