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Conserved domains on  [gi|495315571|ref|WP_008040318|]
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MULTISPECIES: LuxR family transcriptional regulator [unclassified Pseudomonas]

Protein Classification

helix-turn-helix transcriptional regulator( domain architecture ID 10507063)

helix-turn-helix (HTH) transcriptional regulator containing an N-terminal an autoinducer binding domain and a LuxR family HTH DNA-binding domain; may act as an activator or repressor in response to an inducer

Gene Ontology:  GO:0006355|GO:0003677|GO:0003700
PubMed:  15808743|19076237|10473770|8831795

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Autoind_bind pfam03472
Autoinducer binding domain; This domain is found a a large family of transcriptional ...
 18-158 3.38e-24

Autoinducer binding domain; This domain is found a a large family of transcriptional regulators. This domain specifically binds to autoinducer molecules (N-Acyl homoserine lactones, chlorolactone and rosmarinic acid) (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


:

Pssm-ID: 427319  Cd Length: 148  Bit Score: 93.97  E-value: 3.38e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495315571   18 IDAAYPIALEFAKNIGFKFFAFSTTYQTKNNQLNTIRHNNYPTIWNKYYEQKNLSSVDPVVAHCNHSMLPIMWSETLFS- 96
Cdd:pfam03472   2 EEELFDALARLAAALGFDHFAYGARAPLGLSAPDVLVLSNYPAEWLDRYDEANYFAIDPVVRHARRSSSPFSWSDVLFAe 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 495315571   97 ---KVPSLWEALETHGLQHGWSQSLHDeDSGLCSILSLARSHCPITALELYENLGFSVFMCRHLH 158
Cdd:pfam03472  82 argAERRFLDEARDFGLRDGYTVPVHG-PGGRLGALSFAGPGEDLDPAEAIEAAARLQLLAIYAH 145
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
156-223 6.80e-15

DNA-binding transcriptional regulator, CsgD family [Transcription];


:

Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 70.55  E-value: 6.80e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 495315571 156 HLHALIAQSLPKKMLKPPAAHLSPREIDVLELAAAGKTAEESARILNLSARTIHFHIQSVILKLGVSN 223
Cdd:COG2771  107 ALALAALLLAALARLLARAPGLTPREREVLRLLAEGLTLKEIARILGISERTVRTHLKRIYRKLGVSS 174
 
Name Accession Description Interval E-value
Autoind_bind pfam03472
Autoinducer binding domain; This domain is found a a large family of transcriptional ...
 18-158 3.38e-24

Autoinducer binding domain; This domain is found a a large family of transcriptional regulators. This domain specifically binds to autoinducer molecules (N-Acyl homoserine lactones, chlorolactone and rosmarinic acid) (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 427319  Cd Length: 148  Bit Score: 93.97  E-value: 3.38e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495315571   18 IDAAYPIALEFAKNIGFKFFAFSTTYQTKNNQLNTIRHNNYPTIWNKYYEQKNLSSVDPVVAHCNHSMLPIMWSETLFS- 96
Cdd:pfam03472   2 EEELFDALARLAAALGFDHFAYGARAPLGLSAPDVLVLSNYPAEWLDRYDEANYFAIDPVVRHARRSSSPFSWSDVLFAe 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 495315571   97 ---KVPSLWEALETHGLQHGWSQSLHDeDSGLCSILSLARSHCPITALELYENLGFSVFMCRHLH 158
Cdd:pfam03472  82 argAERRFLDEARDFGLRDGYTVPVHG-PGGRLGALSFAGPGEDLDPAEAIEAAARLQLLAIYAH 145
PRK10188 PRK10188
transcriptional regulator SdiA;
55-211 1.59e-22

transcriptional regulator SdiA;


Pssm-ID: 182292 [Multi-domain]  Cd Length: 240  Bit Score: 92.16  E-value: 1.59e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495315571  55 HNNYPTIWNKYYEQKNLSSVDPVVAHCNHSMLPIMWSETLFSKVPSLWEALETHGLQHGWSQS--LHDEDSGLCSILSLA 132
Cdd:PRK10188  60 YTTYPEAWVSHYQAENYFAIDPVLKPENFSQGHLMWNDDLFSEAQALWDAARAHGLRRGVTQClmLPNRALGFLSFSRCS 139

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495315571 133 RSHCPITALELYENLGFSVFMCrhLHALIaqSLPKKMLKPPAAHLSPREIDVLELAAAGKTAEESARILNLSARTIHFH 211
Cdd:PRK10188 140 AREIPILSDELELRLQLLVRES--LMALM--RLEDEMVMTPEMNFSKREKEILKWTAEGKTSAEIAMILSISENTVNFH 214
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
156-223 6.80e-15

DNA-binding transcriptional regulator, CsgD family [Transcription];


Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 70.55  E-value: 6.80e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 495315571 156 HLHALIAQSLPKKMLKPPAAHLSPREIDVLELAAAGKTAEESARILNLSARTIHFHIQSVILKLGVSN 223
Cdd:COG2771  107 ALALAALLLAALARLLARAPGLTPREREVLRLLAEGLTLKEIARILGISERTVRTHLKRIYRKLGVSS 174
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 174-223 5.88e-14

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 64.47  E-value: 5.88e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 495315571   174 AAHLSPREIDVLELAAAGKTAEESARILNLSARTIHFHIQSVILKLGVSN 223
Cdd:smart00421   1 LASLTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRS 50
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 177-223 1.49e-12

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 60.63  E-value: 1.49e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 495315571 177 LSPREIDVLELAAAGKTAEESARILNLSARTIHFHIQSVILKLGVSN 223
Cdd:cd06170    1 LTPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKS 47
GerE pfam00196
Bacterial regulatory proteins, luxR family;
177-223 6.97e-12

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 58.75  E-value: 6.97e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 495315571  177 LSPREIDVLELAAAGKTAEESARILNLSARTIHFHIQSVILKLGVSN 223
Cdd:pfam00196   3 LSPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHS 49
PRK10840 PRK10840
transcriptional regulator RcsB; Provisional
 177-223 5.06e-05

transcriptional regulator RcsB; Provisional


Pssm-ID: 182771 [Multi-domain]  Cd Length: 216  Bit Score: 42.90  E-value: 5.06e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 495315571 177 LSPREIDVLELAAAGKTAEESARILNLSARTIHFHIQSVILKLGVSN 223
Cdd:PRK10840 151 LSPKESEVLRLFAEGFLVTEIAKKLNRSIKTISSQKKSAMMKLGVEN 197
 
Name Accession Description Interval E-value
Autoind_bind pfam03472
Autoinducer binding domain; This domain is found a a large family of transcriptional ...
 18-158 3.38e-24

Autoinducer binding domain; This domain is found a a large family of transcriptional regulators. This domain specifically binds to autoinducer molecules (N-Acyl homoserine lactones, chlorolactone and rosmarinic acid) (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 427319  Cd Length: 148  Bit Score: 93.97  E-value: 3.38e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495315571   18 IDAAYPIALEFAKNIGFKFFAFSTTYQTKNNQLNTIRHNNYPTIWNKYYEQKNLSSVDPVVAHCNHSMLPIMWSETLFS- 96
Cdd:pfam03472   2 EEELFDALARLAAALGFDHFAYGARAPLGLSAPDVLVLSNYPAEWLDRYDEANYFAIDPVVRHARRSSSPFSWSDVLFAe 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 495315571   97 ---KVPSLWEALETHGLQHGWSQSLHDeDSGLCSILSLARSHCPITALELYENLGFSVFMCRHLH 158
Cdd:pfam03472  82 argAERRFLDEARDFGLRDGYTVPVHG-PGGRLGALSFAGPGEDLDPAEAIEAAARLQLLAIYAH 145
PRK10188 PRK10188
transcriptional regulator SdiA;
55-211 1.59e-22

transcriptional regulator SdiA;


Pssm-ID: 182292 [Multi-domain]  Cd Length: 240  Bit Score: 92.16  E-value: 1.59e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495315571  55 HNNYPTIWNKYYEQKNLSSVDPVVAHCNHSMLPIMWSETLFSKVPSLWEALETHGLQHGWSQS--LHDEDSGLCSILSLA 132
Cdd:PRK10188  60 YTTYPEAWVSHYQAENYFAIDPVLKPENFSQGHLMWNDDLFSEAQALWDAARAHGLRRGVTQClmLPNRALGFLSFSRCS 139

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495315571 133 RSHCPITALELYENLGFSVFMCrhLHALIaqSLPKKMLKPPAAHLSPREIDVLELAAAGKTAEESARILNLSARTIHFH 211
Cdd:PRK10188 140 AREIPILSDELELRLQLLVRES--LMALM--RLEDEMVMTPEMNFSKREKEILKWTAEGKTSAEIAMILSISENTVNFH 214
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
156-223 6.80e-15

DNA-binding transcriptional regulator, CsgD family [Transcription];


Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 70.55  E-value: 6.80e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 495315571 156 HLHALIAQSLPKKMLKPPAAHLSPREIDVLELAAAGKTAEESARILNLSARTIHFHIQSVILKLGVSN 223
Cdd:COG2771  107 ALALAALLLAALARLLARAPGLTPREREVLRLLAEGLTLKEIARILGISERTVRTHLKRIYRKLGVSS 174
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 177-223 2.08e-14

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 67.61  E-value: 2.08e-14
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 495315571 177 LSPREIDVLELAAAGKTAEESARILNLSARTIHFHIQSVILKLGVSN 223
Cdd:COG2197   70 LTPREREVLRLLAEGLSNKEIAERLGISERTVKTHVSNILRKLGVRN 116
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 174-223 5.88e-14

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 64.47  E-value: 5.88e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 495315571   174 AAHLSPREIDVLELAAAGKTAEESARILNLSARTIHFHIQSVILKLGVSN 223
Cdd:smart00421   1 LASLTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRS 50
GerE COG5905
Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell ...
 177-223 5.34e-13

Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell division, chromosome partitioning, Transcription];


Pssm-ID: 444607 [Multi-domain]  Cd Length: 76  Bit Score: 62.28  E-value: 5.34e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 495315571 177 LSPREIDVLELAAAGKTAEESARILNLSARTIHFHIQSVILKLGVSN 223
Cdd:COG5905   13 LTKREREVLELLAEGLTNKEIARQLFISEKTVKNHVSNILRKLGVRN 59
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 177-223 1.49e-12

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 60.63  E-value: 1.49e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 495315571 177 LSPREIDVLELAAAGKTAEESARILNLSARTIHFHIQSVILKLGVSN 223
Cdd:cd06170    1 LTPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKS 47
GerE pfam00196
Bacterial regulatory proteins, luxR family;
177-223 6.97e-12

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 58.75  E-value: 6.97e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 495315571  177 LSPREIDVLELAAAGKTAEESARILNLSARTIHFHIQSVILKLGVSN 223
Cdd:pfam00196   3 LSPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHS 49
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 175-223 4.56e-09

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 54.34  E-value: 4.56e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 495315571 175 AHLSPREIDVLELAAAGKTAEESARILNLSARTIHFHIQSVILKLGVSN 223
Cdd:COG4566  136 ASLTPREREVLDLVVAGLSNKQIARELGISPRTVEVHRANVMEKLGARS 184
MalT COG2909
ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];
98-223 3.87e-06

ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];


Pssm-ID: 442153 [Multi-domain]  Cd Length: 184  Bit Score: 45.85  E-value: 3.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495315571  98 VPSLWEALEthglqhGWSQSLHDEDSglcsilslARSHCPiTALELYENLGFSVFMCRHLHALiaqslpkkmLKPPAAHL 177
Cdd:COG2909   72 AARLAERTE------GWARLALDPEE--------ALALLE-RLLALAEAAGRLLLRALALRAL---------GDREEALA 127

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 495315571 178 SPREidvlELAAAGKTAEESARILNLSARTIHFHIQSVILKLGVSN 223
Cdd:COG2909  128 ALRR----RLLAEGLSNKEIAERLFISVNTVKTHLRNIYRKLGVRS 169
PRK10840 PRK10840
transcriptional regulator RcsB; Provisional
 177-223 5.06e-05

transcriptional regulator RcsB; Provisional


Pssm-ID: 182771 [Multi-domain]  Cd Length: 216  Bit Score: 42.90  E-value: 5.06e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 495315571 177 LSPREIDVLELAAAGKTAEESARILNLSARTIHFHIQSVILKLGVSN 223
Cdd:PRK10840 151 LSPKESEVLRLFAEGFLVTEIAKKLNRSIKTISSQKKSAMMKLGVEN 197
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
173-221 2.41e-04

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 40.99  E-value: 2.41e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 495315571 173 PAAHLSPREIDVLELAAAGKTAEESARILNLSARTIHFHIQSVILKLGV 221
Cdd:PRK10403 150 PFSVLTERELDVLHELAQGLSNKQIASVLNISEQTVKVHIRNLLRKLNV 198
PRK10360 PRK10360
transcriptional regulator UhpA;
177-223 3.27e-04

transcriptional regulator UhpA;


Pssm-ID: 182408 [Multi-domain]  Cd Length: 196  Bit Score: 40.35  E-value: 3.27e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 495315571 177 LSPREIDVLELAAAGKTAEESARILNLSARTIHFHIQSVILKLGVSN 223
Cdd:PRK10360 138 LTKRERQVAEKLAQGMAVKEIAAELGLSPKTVHVHRANLMEKLGVSN 184
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 157-220 3.80e-04

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 40.40  E-value: 3.80e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 495315571 157 LHALIAQSL--PKKMLKPPAAHLSPREIDVLELAAAGKTAEESARILNLSARTIHFHIQSVILKLG 220
Cdd:PRK10651 134 LTPVLAASLraNRATTERDVNQLTPRERDILKLIAQGLPNKMIARRLDITESTVKVHVKHMLKKMK 199
fixJ PRK09390
response regulator FixJ; Provisional
 175-223 7.43e-03

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 36.52  E-value: 7.43e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 495315571 175 AHLSPREIDVLELAAAGKTAEESARILNLSARTIHFHIQSVILKLGVSN 223
Cdd:PRK09390 140 ASLSERERQVMDGLVAGLSNKVIARDLDISPRTVEVYRANVMTKMQAGS 188
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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