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Conserved domains on  [gi|495295774|ref|WP_008020527|]
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MULTISPECIES: phosphopantetheine-binding protein [Bacteroides]

Protein Classification

acyl carrier protein( domain architecture ID 516)

acyl carrier protein may function as a carrier of the growing fatty acid chain in fatty acid biosynthesis or as the carrier of activated (amino) acid groups in polyketide synthases and non-ribosomal peptide synthases

Gene Ontology:  GO:0006633
PubMed:  30543875

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PP-binding super family cl09936
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 10-91 6.85e-23

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


The actual alignment was detected with superfamily member PRK09184:

Pssm-ID: 447865  Cd Length: 89  Bit Score: 83.95  E-value: 6.85e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495295774 10 ELMDEVKGKLIEELNLEEITPEDIDDEAPLFGdEGLGLDSIDALEIILILEREYGIKI--ENPsEGKQIFYSVCTLTDYI 87
Cdd:PRK09184  6 ALERELAELIVEELNLEDVQPESIDADAPLYG-EGLGLDSIDILEIALVISKRYGFQLrsDNP-DNQRIFASLRALAAYV 83


                ....
gi 495295774 88 IANR 91
Cdd:PRK09184 84 AAHR 87
 
Name Accession Description Interval E-value
PRK09184 PRK09184
acyl carrier protein; Provisional
 10-91 6.85e-23

acyl carrier protein; Provisional


Pssm-ID: 181682  Cd Length: 89  Bit Score: 83.95  E-value: 6.85e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495295774 10 ELMDEVKGKLIEELNLEEITPEDIDDEAPLFGdEGLGLDSIDALEIILILEREYGIKI--ENPsEGKQIFYSVCTLTDYI 87
Cdd:PRK09184  6 ALERELAELIVEELNLEDVQPESIDADAPLYG-EGLGLDSIDILEIALVISKRYGFQLrsDNP-DNQRIFASLRALAAYV 83


                ....
gi 495295774 88 IANR 91
Cdd:PRK09184 84 AAHR 87
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 7-92 6.86e-11

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 52.93  E-value: 6.86e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495295774  7 TKRELMDEVKGKLIEELNLEeitPEDIDDEAPLFGDegLGLDSIDALEIILILEREYGIKIenPSEGKQIFYSVCTLTDY 86
Cdd:COG0236   2 PREELEERLAEIIAEVLGVD---PEEITPDDSFFED--LGLDSLDAVELIAALEEEFGIEL--PDTELFEYPTVADLADY 74


                ....*.
gi 495295774 87 IIANRK 92
Cdd:COG0236  75 LEEKLA 80
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 13-68 9.05e-07

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 42.17  E-value: 9.05e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 495295774  13 DEVKGKLIEELNLEeitPEDIDDEAPLFGdegLGLDSIDALEIILILEREYGIKIE 68
Cdd:pfam00550  1 ERLRELLAEVLGVP---AEEIDPDTDLFD---LGLDSLLAVELIARLEEEFGVEIP 50
PKS_PP smart00823
Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the ...
 5-67 1.68e-05

Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where it serves as a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups.


Pssm-ID: 214834 [Multi-domain]  Cd Length: 86  Bit Score: 39.54  E-value: 1.68e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 495295774    5 DQTKRELMDEVKGKLIEELNLEeiTPEDIDDEAPLFGdegLGLDSIDALEIILILEREYGIKI 67
Cdd:smart00823  7 AERRRLLLDLVREQVAAVLGHA--AAEAIDPDRPFRD---LGLDSLMAVELRNRLEAATGLRL 64
acyl_carrier TIGR00517
acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser ...
 8-87 3.19e-04

acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser residue. It acts as a carrier of the growing fatty acid chain, which is bound to the prosthetic group, during fatty acid biosynthesis. Homologous phosphopantetheine-binding domains are found in longer proteins. Acyl carrier proteins scoring above the noise cutoff but below the trusted cutoff may be specialized versions. These include those involved in mycolic acid biosynthesis in the Mycobacteria, lipid A biosynthesis in Rhizobium, actinorhodin polyketide synthesis in Streptomyces coelicolor, etc. This protein is not found in the Archaea.Gene name acpP.S (Ser) at position 37 in the seed alignment, in the motif DSLD, is the phosphopantetheine attachment site. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 213536 [Multi-domain]  Cd Length: 77  Bit Score: 35.84  E-value: 3.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495295774   8 KRELMDEVKGKLIEELNleeITPEDIDDEAPLFGDegLGLDSIDALEIILILEREYGIKIenPSEGKQIFYSVCTLTDYI 87
Cdd:TIGR00517  1 MQEIFEKVKAIIKEQLN---VDEDQITTDARFVED--LGADSLDTVELVMALEEEFDIEI--PDEEAEKIATVGDAVNYI 73
 
Name Accession Description Interval E-value
PRK09184 PRK09184
acyl carrier protein; Provisional
 10-91 6.85e-23

acyl carrier protein; Provisional


Pssm-ID: 181682  Cd Length: 89  Bit Score: 83.95  E-value: 6.85e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495295774 10 ELMDEVKGKLIEELNLEEITPEDIDDEAPLFGdEGLGLDSIDALEIILILEREYGIKI--ENPsEGKQIFYSVCTLTDYI 87
Cdd:PRK09184  6 ALERELAELIVEELNLEDVQPESIDADAPLYG-EGLGLDSIDILEIALVISKRYGFQLrsDNP-DNQRIFASLRALAAYV 83


                ....
gi 495295774 88 IANR 91
Cdd:PRK09184 84 AAHR 87
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 7-92 6.86e-11

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 52.93  E-value: 6.86e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495295774  7 TKRELMDEVKGKLIEELNLEeitPEDIDDEAPLFGDegLGLDSIDALEIILILEREYGIKIenPSEGKQIFYSVCTLTDY 86
Cdd:COG0236   2 PREELEERLAEIIAEVLGVD---PEEITPDDSFFED--LGLDSLDAVELIAALEEEFGIEL--PDTELFEYPTVADLADY 74


                ....*.
gi 495295774 87 IIANRK 92
Cdd:COG0236  75 LEEKLA 80
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 13-68 9.05e-07

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 42.17  E-value: 9.05e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 495295774  13 DEVKGKLIEELNLEeitPEDIDDEAPLFGdegLGLDSIDALEIILILEREYGIKIE 68
Cdd:pfam00550  1 ERLRELLAEVLGVP---AEEIDPDTDLFD---LGLDSLLAVELIARLEEEFGVEIP 50
PRK05350 PRK05350
acyl carrier protein; Provisional
 5-89 1.91e-06

acyl carrier protein; Provisional


Pssm-ID: 180033  Cd Length: 82  Bit Score: 41.90  E-value: 1.91e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495295774  5 DQTKRELMDEVKGKLIEELnleEITPEDIDDEAPLFGDegLGLDSIDALEIILILEREYGIKIEnPSEgkqiFYSVCTLT 84
Cdd:PRK05350  1 MMTREEILERLRAILVELF---EIDPEDITPEANLYED--LDLDSIDAVDLVVHLQKLTGKKIK-PEE----FKSVRTVQ 70


                ....*
gi 495295774 85 DYIIA 89
Cdd:PRK05350 71 DVVDA 75
PKS_PP smart00823
Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the ...
 5-67 1.68e-05

Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where it serves as a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups.


Pssm-ID: 214834 [Multi-domain]  Cd Length: 86  Bit Score: 39.54  E-value: 1.68e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 495295774    5 DQTKRELMDEVKGKLIEELNLEeiTPEDIDDEAPLFGdegLGLDSIDALEIILILEREYGIKI 67
Cdd:smart00823  7 AERRRLLLDLVREQVAAVLGHA--AAEAIDPDRPFRD---LGLDSLMAVELRNRLEAATGLRL 64
AcpA COG3433
Acyl carrier protein/domain [Lipid transport and metabolism, Secondary metabolites ...
 27-71 1.38e-04

Acyl carrier protein/domain [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442659 [Multi-domain]  Cd Length: 295  Bit Score: 38.58  E-value: 1.38e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 495295774  27 EITPEDIDDEAPLFgdeGLGLDSIDALEIILILeREYGIKI------ENPS 71
Cdd:COG3433  233 GVDPEEIDPDDNLF---DLGLDSIRLMQLVERW-RKAGLDVsfadlaEHPT 279
acyl_carrier TIGR00517
acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser ...
 8-87 3.19e-04

acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser residue. It acts as a carrier of the growing fatty acid chain, which is bound to the prosthetic group, during fatty acid biosynthesis. Homologous phosphopantetheine-binding domains are found in longer proteins. Acyl carrier proteins scoring above the noise cutoff but below the trusted cutoff may be specialized versions. These include those involved in mycolic acid biosynthesis in the Mycobacteria, lipid A biosynthesis in Rhizobium, actinorhodin polyketide synthesis in Streptomyces coelicolor, etc. This protein is not found in the Archaea.Gene name acpP.S (Ser) at position 37 in the seed alignment, in the motif DSLD, is the phosphopantetheine attachment site. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 213536 [Multi-domain]  Cd Length: 77  Bit Score: 35.84  E-value: 3.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495295774   8 KRELMDEVKGKLIEELNleeITPEDIDDEAPLFGDegLGLDSIDALEIILILEREYGIKIenPSEGKQIFYSVCTLTDYI 87
Cdd:TIGR00517  1 MQEIFEKVKAIIKEQLN---VDEDQITTDARFVED--LGADSLDTVELVMALEEEFDIEI--PDEEAEKIATVGDAVNYI 73
PRK07639 PRK07639
petrobactin biosynthesis protein AsbD;
7-87 1.32e-03

petrobactin biosynthesis protein AsbD;


Pssm-ID: 181065  Cd Length: 86  Bit Score: 34.34  E-value: 1.32e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495295774  7 TKRELMDEVKGKLIEELNLEEITpeDIDDEAPLfgDEGLGLDSIDALEIILILEREYGIKIENPSEGKQIFYSVCTLTDY 86
Cdd:PRK07639  2 RREALKNAVLKIMEEKLELKNVT--HLEETMRL--NEDLYIDSVMMLQLIVYIEMDVKLCVPEDEVDPKAFLTVGSLLDF 77


                .
gi 495295774 87 I 87
Cdd:PRK07639 78 M 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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