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Conserved domains on  [gi|495174087|ref|WP_007898882|]
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MULTISPECIES: glutaredoxin-dependent arsenate reductase [Enterobacterales]

Protein Classification

arsenate reductase (glutaredoxin)( domain architecture ID 10793334)

arsenate reductase (glutaredoxin) catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)]

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10026 PRK10026
arsenate reductase (glutaredoxin);
1-141 7.50e-104

arsenate reductase (glutaredoxin);


:

Pssm-ID: 182200  Cd Length: 141  Bit Score: 292.49  E-value: 7.50e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495174087   1 MSNITIYHNPACGTSRNTLEMIRNSGNEPTIIYYLDTPPTRDELIKLISDMGITVRALLRKNVEPYEHLGLDEEKFSDEQ 80
Cdd:PRK10026   1 MSNITIYHNPACGTSRNTLEMIRNSGTEPTIIHYLETPPTRDELVKLIADMGISVRALLRKNVEPYEELGLAEDKFTDDQ 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 495174087  81 LIDFMLQHPILINRPVVVTPLGTRLCRPSEIVLDILPEGQKGAFTKEDGEKIIDETGKRVK 141
Cdd:PRK10026  81 LIDFMLQHPILINRPIVVTPLGTRLCRPSEVVLEILPDAQKGAFTKEDGEKVVDEAGKRLK 141
 
Name Accession Description Interval E-value
PRK10026 PRK10026
arsenate reductase (glutaredoxin);
1-141 7.50e-104

arsenate reductase (glutaredoxin);


Pssm-ID: 182200  Cd Length: 141  Bit Score: 292.49  E-value: 7.50e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495174087   1 MSNITIYHNPACGTSRNTLEMIRNSGNEPTIIYYLDTPPTRDELIKLISDMGITVRALLRKNVEPYEHLGLDEEKFSDEQ 80
Cdd:PRK10026   1 MSNITIYHNPACGTSRNTLEMIRNSGTEPTIIHYLETPPTRDELVKLIADMGISVRALLRKNVEPYEELGLAEDKFTDDQ 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 495174087  81 LIDFMLQHPILINRPVVVTPLGTRLCRPSEIVLDILPEGQKGAFTKEDGEKIIDETGKRVK 141
Cdd:PRK10026  81 LIDFMLQHPILINRPIVVTPLGTRLCRPSEVVLEILPDAQKGAFTKEDGEKVVDEAGKRLK 141
ArsC_ArsC cd03034
Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded ...
 4-115 4.71e-62

Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the detoxification of arsenic, using reducing equivalents derived from glutathione (GSH) via glutaredoxin (GRX). ArsC contains a single catalytic cysteine, within a thioredoxin fold, that forms a covalent thiolate-As(V) intermediate, which is reduced by GRX through a mixed GSH-arsenate intermediate. This family of predominantly bacterial enzymes is unrelated to two other families of arsenate reductases which show similarity to low-molecular-weight acid phosphatases and phosphotyrosyl phosphatases.


Pssm-ID: 239332  Cd Length: 112  Bit Score: 185.87  E-value: 4.71e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495174087   4 ITIYHNPACGTSRNTLEMIRNSGNEPTIIYYLDTPPTRDELIKLISDMGITVRALLRKNVEPYEHLGLDEEKFSDEQLID 83
Cdd:cd03034    1 ITIYHNPRCSKSRNALALLEEAGIEPEIVEYLKTPPTAAELRELLAKLGISPRDLLRTKEAPYKELGLADPELSDEELID 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 495174087  84 FMLQHPILINRPVVVTPLGTRLCRPSEIVLDI 115
Cdd:cd03034   81 AMAAHPILIERPIVVTGDGAVLGRPPEAVLEL 112
arsC TIGR00014
arsenate reductase (glutaredoxin); This model describes a distinct clade, including ArsC ...
 4-116 7.07e-47

arsenate reductase (glutaredoxin); This model describes a distinct clade, including ArsC itself, of the broader ArsC family described by Pfam pfam03960. This clade is almost completely restricted to the Proteobacteria. An anion-translocating ATPase has been identified as the product of the arsenical resistance operon of resistance plasmid R773. When expressed in Escherichia coli this ATP-driven oxyanion pump catalyses extrusion of the oxyanions arsenite, antimonite and arsenate. The pump is composed of two polypeptides, the products of the arsA and arsB genes. The pump alone produces resistance to arsenite and antimonite. This protein, ArsC, catalyzes the reduction of arsenate to arsenite, and thus extends resistance to include arsenate. [Cellular processes, Detoxification]


Pssm-ID: 272855  Cd Length: 114  Bit Score: 147.60  E-value: 7.07e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495174087    4 ITIYHNPACGTSRNTLEMIRNSGNEPTIIYYLDTPPTRDELIKLISDMGITV-RALLRKNVEPYEHLGLDEEKFSDEQLI 82
Cdd:TIGR00014   1 VTIYHNPRCSKSRNTLALLEDKGIEPEVVKYLKNPPTKSELEAIFAKLGLTVaREMIRTKEALYKELGLSDPNLSDQELL 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 495174087   83 DFMLQHPILINRPVVVTPLGTRLCRPSEIVLDIL 116
Cdd:TIGR00014  81 DAMVAHPILLERPIVVAGDGARIGRPPENVLDIL 114
ArsC COG1393
Arsenate reductase or related protein, glutaredoxin family [Inorganic ion transport and ...
 3-117 2.22e-46

Arsenate reductase or related protein, glutaredoxin family [Inorganic ion transport and metabolism];


Pssm-ID: 441003  Cd Length: 115  Bit Score: 146.01  E-value: 2.22e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495174087   3 NITIYHNPACGTSRNTLEMIRNSGNEPTIIYYLDTPPTRDELIKLISDMGITVRALLRKNVEPYEHLGLDEEKFSDEQLI 82
Cdd:COG1393    1 MITIYGNPNCSTSRKALAWLEEAGIEYEFIDYLKTPPTAEELKELLAKLGLGVEELLNTRGTTYRELGLKDKALSEEEAL 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 495174087  83 DFMLQHPILINRPVVVTPLGTRLCRPSEIVLDILP 117
Cdd:COG1393   81 ALMLEHPSLIKRPIVVTGDKALVGFPPEEVLALLG 115
ArsC pfam03960
ArsC family; This family is related to glutaredoxins pfam00462.
 7-115 2.50e-40

ArsC family; This family is related to glutaredoxins pfam00462.


Pssm-ID: 427617  Cd Length: 109  Bit Score: 130.80  E-value: 2.50e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495174087    7 YHNPACGTSRNTLEMIRNSGNEPTIIYYLDTPPTRDELIKLISDMGITVRALLRKNVEPYEHLGLDEEKFSDEQLIDFML 86
Cdd:pfam03960   1 YGSPNCSTCRKALAWLEEHGIEYQEIDYLETPPSKEELKDILAKLGDGVEALLNTRGTTYRELNLDKEDLSEDELLELIL 80

                          90       100
                  ....*....|....*....|....*....
gi 495174087   87 QHPILINRPVVVTPLGTRLCRPSEIVLDI 115
Cdd:pfam03960  81 EHPSLIRRPIVVDGGKLLVGFNEEEIRAF 109
 
Name Accession Description Interval E-value
PRK10026 PRK10026
arsenate reductase (glutaredoxin);
1-141 7.50e-104

arsenate reductase (glutaredoxin);


Pssm-ID: 182200  Cd Length: 141  Bit Score: 292.49  E-value: 7.50e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495174087   1 MSNITIYHNPACGTSRNTLEMIRNSGNEPTIIYYLDTPPTRDELIKLISDMGITVRALLRKNVEPYEHLGLDEEKFSDEQ 80
Cdd:PRK10026   1 MSNITIYHNPACGTSRNTLEMIRNSGTEPTIIHYLETPPTRDELVKLIADMGISVRALLRKNVEPYEELGLAEDKFTDDQ 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 495174087  81 LIDFMLQHPILINRPVVVTPLGTRLCRPSEIVLDILPEGQKGAFTKEDGEKIIDETGKRVK 141
Cdd:PRK10026  81 LIDFMLQHPILINRPIVVTPLGTRLCRPSEVVLEILPDAQKGAFTKEDGEKVVDEAGKRLK 141
ArsC_ArsC cd03034
Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded ...
 4-115 4.71e-62

Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the detoxification of arsenic, using reducing equivalents derived from glutathione (GSH) via glutaredoxin (GRX). ArsC contains a single catalytic cysteine, within a thioredoxin fold, that forms a covalent thiolate-As(V) intermediate, which is reduced by GRX through a mixed GSH-arsenate intermediate. This family of predominantly bacterial enzymes is unrelated to two other families of arsenate reductases which show similarity to low-molecular-weight acid phosphatases and phosphotyrosyl phosphatases.


Pssm-ID: 239332  Cd Length: 112  Bit Score: 185.87  E-value: 4.71e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495174087   4 ITIYHNPACGTSRNTLEMIRNSGNEPTIIYYLDTPPTRDELIKLISDMGITVRALLRKNVEPYEHLGLDEEKFSDEQLID 83
Cdd:cd03034    1 ITIYHNPRCSKSRNALALLEEAGIEPEIVEYLKTPPTAAELRELLAKLGISPRDLLRTKEAPYKELGLADPELSDEELID 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 495174087  84 FMLQHPILINRPVVVTPLGTRLCRPSEIVLDI 115
Cdd:cd03034   81 AMAAHPILIERPIVVTGDGAVLGRPPEAVLEL 112
arsC TIGR00014
arsenate reductase (glutaredoxin); This model describes a distinct clade, including ArsC ...
 4-116 7.07e-47

arsenate reductase (glutaredoxin); This model describes a distinct clade, including ArsC itself, of the broader ArsC family described by Pfam pfam03960. This clade is almost completely restricted to the Proteobacteria. An anion-translocating ATPase has been identified as the product of the arsenical resistance operon of resistance plasmid R773. When expressed in Escherichia coli this ATP-driven oxyanion pump catalyses extrusion of the oxyanions arsenite, antimonite and arsenate. The pump is composed of two polypeptides, the products of the arsA and arsB genes. The pump alone produces resistance to arsenite and antimonite. This protein, ArsC, catalyzes the reduction of arsenate to arsenite, and thus extends resistance to include arsenate. [Cellular processes, Detoxification]


Pssm-ID: 272855  Cd Length: 114  Bit Score: 147.60  E-value: 7.07e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495174087    4 ITIYHNPACGTSRNTLEMIRNSGNEPTIIYYLDTPPTRDELIKLISDMGITV-RALLRKNVEPYEHLGLDEEKFSDEQLI 82
Cdd:TIGR00014   1 VTIYHNPRCSKSRNTLALLEDKGIEPEVVKYLKNPPTKSELEAIFAKLGLTVaREMIRTKEALYKELGLSDPNLSDQELL 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 495174087   83 DFMLQHPILINRPVVVTPLGTRLCRPSEIVLDIL 116
Cdd:TIGR00014  81 DAMVAHPILLERPIVVAGDGARIGRPPENVLDIL 114
ArsC COG1393
Arsenate reductase or related protein, glutaredoxin family [Inorganic ion transport and ...
 3-117 2.22e-46

Arsenate reductase or related protein, glutaredoxin family [Inorganic ion transport and metabolism];


Pssm-ID: 441003  Cd Length: 115  Bit Score: 146.01  E-value: 2.22e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495174087   3 NITIYHNPACGTSRNTLEMIRNSGNEPTIIYYLDTPPTRDELIKLISDMGITVRALLRKNVEPYEHLGLDEEKFSDEQLI 82
Cdd:COG1393    1 MITIYGNPNCSTSRKALAWLEEAGIEYEFIDYLKTPPTAEELKELLAKLGLGVEELLNTRGTTYRELGLKDKALSEEEAL 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 495174087  83 DFMLQHPILINRPVVVTPLGTRLCRPSEIVLDILP 117
Cdd:COG1393   81 ALMLEHPSLIKRPIVVTGDKALVGFPPEEVLALLG 115
ArsC pfam03960
ArsC family; This family is related to glutaredoxins pfam00462.
 7-115 2.50e-40

ArsC family; This family is related to glutaredoxins pfam00462.


Pssm-ID: 427617  Cd Length: 109  Bit Score: 130.80  E-value: 2.50e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495174087    7 YHNPACGTSRNTLEMIRNSGNEPTIIYYLDTPPTRDELIKLISDMGITVRALLRKNVEPYEHLGLDEEKFSDEQLIDFML 86
Cdd:pfam03960   1 YGSPNCSTCRKALAWLEEHGIEYQEIDYLETPPSKEELKDILAKLGDGVEALLNTRGTTYRELNLDKEDLSEDELLELIL 80

                          90       100
                  ....*....|....*....|....*....
gi 495174087   87 QHPILINRPVVVTPLGTRLCRPSEIVLDI 115
Cdd:pfam03960  81 EHPSLIRRPIVVDGGKLLVGFNEEEIRAF 109
ArsC_family cd02977
Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins ...
 4-107 1.25e-38

Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from glutathione (GSH) via glutaredoxin (GRX), through a single catalytic cysteine. This family of predominantly bacterial enzymes is unrelated to two other families of arsenate reductases which show similarity to low-molecular-weight acid phosphatases and phosphotyrosyl phosphatases. Spx is a general regulator that exerts negative and positive control over transcription initiation by binding to the C-terminal domain of the alpha subunit of RNA polymerase.


Pssm-ID: 239275  Cd Length: 105  Bit Score: 126.07  E-value: 1.25e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495174087   4 ITIYHNPACGTSRNTLEMIRNSGNEPTIIYYLDTPPTRDELIKLISDMGITVRALLRKNVEPYEHLGLDEEK-FSDEQLI 82
Cdd:cd02977    1 ITIYGNPNCSTSRKALAWLEEHGIEYEFIDYLKEPPTKEELKELLAKLGLGVEDLFNTRGTPYRKLGLADKDeLSDEEAL 80

                         90       100
                 ....*....|....*....|....*
gi 495174087  83 DFMLQHPILINRPVVVTPLGTRLCR 107
Cdd:cd02977   81 ELMAEHPKLIKRPIVVDGDRLLVGF 105
arsC_related TIGR01617
transcriptional regulator, Spx/MgsR family; This model represents a portion of the proteins ...
 4-100 1.21e-10

transcriptional regulator, Spx/MgsR family; This model represents a portion of the proteins within the larger set covered by pfam03960. That larger family includes a glutaredoxin-dependent arsenate reductase (TIGR00014). Characterized members of this family include Spx and MgsR from Bacillus subtili. Spx is a global regulator for response to thiol-specific oxidative stress. It interacts with RNA polymerase. MgsR (modulator of the general stress response, also called YqgZ) provides a second level of regulation for more than a third of the proteins in the B. subtilis general stress regulon controlled by Sigma-B. [Regulatory functions, DNA interactions]


Pssm-ID: 273720  Cd Length: 117  Bit Score: 55.13  E-value: 1.21e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495174087    4 ITIYHNPACGTSRNTLEMIRNSGNEPTIIYYLDTPPTRDELIKLISDMGITVRALLRKNVEPYEHLGLDEEK--FSDEQL 81
Cdd:TIGR01617   1 IKVYGSPNCTTCKKARRWLEANGIEYQFIDIGEDGPTREELLDILSLLEDGIDPLLNTRGQSYRALNTSNTFldLSDKEA 80

                          90
                  ....*....|....*....
gi 495174087   82 IDFMLQHPILINRPVVVTP 100
Cdd:TIGR01617  81 LELLAEDPALLRRPLIVDT 99
ArsC_like cd03036
Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a ...
 4-100 1.16e-08

Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX) function as protein disulfide oxidoreductases, altering the redox state of target proteins via the reversible oxidation of the active site dithiol. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from glutathione via GRX, through a single catalytic cysteine.


Pssm-ID: 239334  Cd Length: 111  Bit Score: 49.55  E-value: 1.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495174087   4 ITIYHNPACGTSRNTLEMIRNSGNEPTIIYYLDTPPTRDELIKLISDMGITVRALLRKNVEPYEHLGLDE--EKFSDEQL 81
Cdd:cd03036    1 LKFYEYPKCSTCRKAKKWLDEHGVDYTAIDIVEEPPSKEELKKWLEKSGLPLKKFFNTSGKSYRELGLKDklPSLSEEEA 80

                         90
                 ....*....|....*....
gi 495174087  82 IDFMLQHPILINRPVVVTP 100
Cdd:cd03036   81 LELLSSDGMLIKRPFVVDD 99
ArsC_15kD cd03033
Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown ...
 3-95 5.00e-06

Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also encodes dinitrogenase reductase ADP-ribosyltransferase (DRAT) and dinitrogenase reductase activating glycohydrolase (DRAG). ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from glutathione via glutaredoxin, through a single catalytic cysteine.


Pssm-ID: 239331  Cd Length: 113  Bit Score: 42.65  E-value: 5.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495174087   3 NITIYHNPACGTSRNTLEMIRNSGNEPTIIYYLDTPPTRDELIKLISDMGITV---RALLR-KNVEpyehlgLDEEKFSD 78
Cdd:cd03033    1 DIIFYEKPGCANNARQKALLEAAGHEVEVRDLLTEPWTAETLRPFFGDLPVAEwfnPAAPRvKSGE------VVPEALDE 74

                         90
                 ....*....|....*..
gi 495174087  79 EQLIDFMLQHPILINRP 95
Cdd:cd03033   75 EEALALMIADPLLIRRP 91
ArsC_Spx cd03032
Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding ...
 3-98 2.53e-05

Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex formation between RNAP and certain transcriptional activator proteins like ResD and ComA. In response to oxidative stress, Spx can also activate transcription, making it a general regulator that exerts both positive and negative control over transcription initiation. Spx has been shown to exert redox-sensitive transcriptional control over genes like trxA (TRX) and trxB (TRX reductase), genes that function in thiol homeostasis. This redox-sensitive activity is dependent on the presence of a CXXC motif, present in some members of the Spx subfamily, that acts as a thiol/disulfide switch. Spx has also been shown to repress genes in a sulfate-dependent manner independent of the presence of the CXXC motif.


Pssm-ID: 239330  Cd Length: 115  Bit Score: 40.69  E-value: 2.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495174087   3 NITIYHNPACGTSRNTLEMIRNSGNEPTIIYYLDTPPTRDELIKLISDMGITVRALLRKNVEPYEHLGLDEEKFSDEQLI 82
Cdd:cd03032    1 MIKLYTSPSCSSCRKAKQWLEEHQIPFEERNLFKQPLTKEELKEILSLTENGVEDIISTRSKAFKNLNIDIDELSLSELI 80

                         90
                 ....*....|....*.
gi 495174087  83 DFMLQHPILINRPVVV 98
Cdd:cd03032   81 RLISEHPSLLRRPIII 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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