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Conserved domains on  [gi|495147130|ref|WP_007871937|]
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MULTISPECIES: tRNA (guanosine(18)-2'-O)-methyltransferase TrmH [Cronobacter]

Protein Classification

tRNA (guanosine(18)-2'-O)-methyltransferase TrmH( domain architecture ID 11485189)

tRNA (guanosine(18)-2'-O)-methyltransferase TrmH is a member of SpoU family of MTases, which catalyzes the transfer of the methyl group from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of the ribose of the conserved guanosine 18 (G18)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11081 PRK11081
tRNA guanosine-2'-O-methyltransferase; Provisional
 1-229 0e+00

tRNA guanosine-2'-O-methyltransferase; Provisional


:

Pssm-ID: 236837 [Multi-domain]  Cd Length: 229  Bit Score: 494.13  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130   1 MNSQRYARICEMLARRQPDLTVCMEQVHKPHNVSAIIRTADAVGVHEVHAVWPGNRMRTMASSAAGSNSWVEVKTHRNIS 80
Cdd:PRK11081   1 MNPERYARICEMLARRQPDLTVCMEQVHKPHNVSAIIRTADAVGVHEVHAVWPGSRMRTMGSTAAGSNSWVQVKTHRTIG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130  81 DAVNHLKARGMQILATHLSDKAVDFREIDYTRPTCILMGQEKTGITEEALSLADQDIIIPMTGMVQSLNVSVASALILYE 160
Cdd:PRK11081  81 DAVAHLKGQGMQILATHLSDTAVDFREIDYTRPTCILMGQEKTGISQEALALADQDIIIPMIGMVQSLNVSVASALILYE 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495147130 161 AQRQRQNAGMYQRANSTLPEEEQQRLLFEGGYPVLAKVAKRKGLPYPRVNEHGEIDAPQDWWATMQAAE 229
Cdd:PRK11081 161 AQRQRQNAGMYLRENSMLPEEEQQRLLFEGGYPVLAKVAKRKGLPYPHIDEQGQIVADADWWATMQAAG 229
 
Name Accession Description Interval E-value
PRK11081 PRK11081
tRNA guanosine-2'-O-methyltransferase; Provisional
 1-229 0e+00

tRNA guanosine-2'-O-methyltransferase; Provisional


Pssm-ID: 236837 [Multi-domain]  Cd Length: 229  Bit Score: 494.13  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130   1 MNSQRYARICEMLARRQPDLTVCMEQVHKPHNVSAIIRTADAVGVHEVHAVWPGNRMRTMASSAAGSNSWVEVKTHRNIS 80
Cdd:PRK11081   1 MNPERYARICEMLARRQPDLTVCMEQVHKPHNVSAIIRTADAVGVHEVHAVWPGSRMRTMGSTAAGSNSWVQVKTHRTIG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130  81 DAVNHLKARGMQILATHLSDKAVDFREIDYTRPTCILMGQEKTGITEEALSLADQDIIIPMTGMVQSLNVSVASALILYE 160
Cdd:PRK11081  81 DAVAHLKGQGMQILATHLSDTAVDFREIDYTRPTCILMGQEKTGISQEALALADQDIIIPMIGMVQSLNVSVASALILYE 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495147130 161 AQRQRQNAGMYQRANSTLPEEEQQRLLFEGGYPVLAKVAKRKGLPYPRVNEHGEIDAPQDWWATMQAAE 229
Cdd:PRK11081 161 AQRQRQNAGMYLRENSMLPEEEQQRLLFEGGYPVLAKVAKRKGLPYPHIDEQGQIVADADWWATMQAAG 229
SpoU-like_TrmH cd18092
SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group ...
 4-165 3.78e-91

SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of the ribose of the universally conserved guanosine 18 (G18) position in tRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349965  Cd Length: 162  Bit Score: 264.71  E-value: 3.78e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130   4 QRYARICEMLARRQPDLTVCMEQVHKPHNVSAIIRTADAVGVHEVHAVWPGNRMRTMASSAAGSNSWVEVKTHRNISDAV 83
Cdd:cd18092    1 ERLERIEEVLARRTRDLTVVLENVHDPHNASAVLRTCDAFGVQDVHVIEPKNKFKKNRGVAMGADKWLDVHRHDSTEECL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130  84 NHLKARGMQILATHLSDKAVDFREIDYTRPTCILMGQEKTGITEEALSLADQDIIIPMTGMVQSLNVSVASALILYEAQR 163
Cdd:cd18092   81 AALKEQGYRIVATSLSPDAVPLDELDYTRPTALVFGNEKDGVSEEALAAADERVYIPMYGFVESLNVSVAAAIILYELQR 160


                 ..
gi 495147130 164 QR 165
Cdd:cd18092  161 QR 162
SpoU_methylase pfam00588
SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.
 19-159 6.23e-50

SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.


Pssm-ID: 425768  Cd Length: 142  Bit Score: 159.62  E-value: 6.23e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130   19 DLTVCMEQVHKPHNVSAIIRTADAVGVHEVHAVWPG---NRMRTMASSAAGSNSWVEVKTHRNISDAVNHLKARGMQILA 95
Cdd:pfam00588   1 PLVVVLDNIQDPGNLGAIIRTAAAFGADGLILVEPRsadPYNPKAIRASAGALFHLPLVVVDNLEEALKDLKEAGYAVVA 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 495147130   96 THLsdKAVDFREIDYTRPTCILMGQEKTGITEEALSLADQDIIIPMTGMVQSLNVSVASALILY 159
Cdd:pfam00588  81 TSL--GGKSLYEIDFPKKVALVFGNEGTGLSNEVLELCDRLVRIPMSGDVESLNVAVAAAIALY 142
SpoU COG0566
tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA ...
 5-168 6.71e-44

tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA G18 (ribose-2'-O)-methylase SpoU is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440332 [Multi-domain]  Cd Length: 265  Bit Score: 148.04  E-value: 6.71e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130   5 RYARICEMLA-RRQPDLTVCMEQVHKPHNVSAIIRTADAVGVHEVhaVWPGNRM----RTMASSAAGSNSWVEVKTHRNI 79
Cdd:COG0566  100 EYADLEDLLAeAGEPPLLLVLDGVQDPGNLGAILRSAAAFGVDGV--ILPKRRAdpynPKVVRASAGALFHVPVARVTNL 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130  80 SDAVNHLKARGMQILATHLsDKAVDFREIDYTRPTCILMGQEKTGITEEALSLADQDIIIPMTGMVQSLNVSVASALILY 159
Cdd:COG0566  178 ADALEELKEAGFWVVGTDL-DGEASLYEVDLPGPVALVLGNEGKGLSRLVLEACDELVRIPMAGGVESLNVAVAAAILLY 256


                 ....*....
gi 495147130 160 EAQRQRQNA 168
Cdd:COG0566  257 EAARQRRAK 265
rRNA_methyl_3 TIGR00186
rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases ...
 30-165 2.48e-23

rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129290 [Multi-domain]  Cd Length: 237  Bit Score: 93.95  E-value: 2.48e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130   30 PHNVSAIIRTADAVGVHEVhaVWPGNRM----RTMASSAAGSNSWVEVKTHRNISDAVNHLKARGMQILATHLSDKAVDF 105
Cdd:TIGR00186 101 PHNLGAILRTAEAFGVDGV--ILPKRRSaplnSTVVKTSSGAVEYVPLARVTNLSRTITKLKESGFWTVGTDLDAQDTLY 178

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130  106 REIDyTRPTCILMGQEKTGITEEALSLADQDIIIPMTGMVQSLNVSVASALILYEAQRQR 165
Cdd:TIGR00186 179 QVKL-TKPLALVVGNEGEGVSRLIKENCDFLIKIPMAGKVDSLNVSVAAGILLFEIKRQR 237
 
Name Accession Description Interval E-value
PRK11081 PRK11081
tRNA guanosine-2'-O-methyltransferase; Provisional
 1-229 0e+00

tRNA guanosine-2'-O-methyltransferase; Provisional


Pssm-ID: 236837 [Multi-domain]  Cd Length: 229  Bit Score: 494.13  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130   1 MNSQRYARICEMLARRQPDLTVCMEQVHKPHNVSAIIRTADAVGVHEVHAVWPGNRMRTMASSAAGSNSWVEVKTHRNIS 80
Cdd:PRK11081   1 MNPERYARICEMLARRQPDLTVCMEQVHKPHNVSAIIRTADAVGVHEVHAVWPGSRMRTMGSTAAGSNSWVQVKTHRTIG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130  81 DAVNHLKARGMQILATHLSDKAVDFREIDYTRPTCILMGQEKTGITEEALSLADQDIIIPMTGMVQSLNVSVASALILYE 160
Cdd:PRK11081  81 DAVAHLKGQGMQILATHLSDTAVDFREIDYTRPTCILMGQEKTGISQEALALADQDIIIPMIGMVQSLNVSVASALILYE 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495147130 161 AQRQRQNAGMYQRANSTLPEEEQQRLLFEGGYPVLAKVAKRKGLPYPRVNEHGEIDAPQDWWATMQAAE 229
Cdd:PRK11081 161 AQRQRQNAGMYLRENSMLPEEEQQRLLFEGGYPVLAKVAKRKGLPYPHIDEQGQIVADADWWATMQAAG 229
SpoU-like_TrmH cd18092
SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group ...
 4-165 3.78e-91

SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of the ribose of the universally conserved guanosine 18 (G18) position in tRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349965  Cd Length: 162  Bit Score: 264.71  E-value: 3.78e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130   4 QRYARICEMLARRQPDLTVCMEQVHKPHNVSAIIRTADAVGVHEVHAVWPGNRMRTMASSAAGSNSWVEVKTHRNISDAV 83
Cdd:cd18092    1 ERLERIEEVLARRTRDLTVVLENVHDPHNASAVLRTCDAFGVQDVHVIEPKNKFKKNRGVAMGADKWLDVHRHDSTEECL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130  84 NHLKARGMQILATHLSDKAVDFREIDYTRPTCILMGQEKTGITEEALSLADQDIIIPMTGMVQSLNVSVASALILYEAQR 163
Cdd:cd18092   81 AALKEQGYRIVATSLSPDAVPLDELDYTRPTALVFGNEKDGVSEEALAAADERVYIPMYGFVESLNVSVAAAIILYELQR 160


                 ..
gi 495147130 164 QR 165
Cdd:cd18092  161 QR 162
SpoU_methylase pfam00588
SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.
 19-159 6.23e-50

SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.


Pssm-ID: 425768  Cd Length: 142  Bit Score: 159.62  E-value: 6.23e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130   19 DLTVCMEQVHKPHNVSAIIRTADAVGVHEVHAVWPG---NRMRTMASSAAGSNSWVEVKTHRNISDAVNHLKARGMQILA 95
Cdd:pfam00588   1 PLVVVLDNIQDPGNLGAIIRTAAAFGADGLILVEPRsadPYNPKAIRASAGALFHLPLVVVDNLEEALKDLKEAGYAVVA 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 495147130   96 THLsdKAVDFREIDYTRPTCILMGQEKTGITEEALSLADQDIIIPMTGMVQSLNVSVASALILY 159
Cdd:pfam00588  81 TSL--GGKSLYEIDFPKKVALVFGNEGTGLSNEVLELCDRLVRIPMSGDVESLNVAVAAAIALY 142
SpoU COG0566
tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA ...
 5-168 6.71e-44

tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA G18 (ribose-2'-O)-methylase SpoU is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440332 [Multi-domain]  Cd Length: 265  Bit Score: 148.04  E-value: 6.71e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130   5 RYARICEMLA-RRQPDLTVCMEQVHKPHNVSAIIRTADAVGVHEVhaVWPGNRM----RTMASSAAGSNSWVEVKTHRNI 79
Cdd:COG0566  100 EYADLEDLLAeAGEPPLLLVLDGVQDPGNLGAILRSAAAFGVDGV--ILPKRRAdpynPKVVRASAGALFHVPVARVTNL 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130  80 SDAVNHLKARGMQILATHLsDKAVDFREIDYTRPTCILMGQEKTGITEEALSLADQDIIIPMTGMVQSLNVSVASALILY 159
Cdd:COG0566  178 ADALEELKEAGFWVVGTDL-DGEASLYEVDLPGPVALVLGNEGKGLSRLVLEACDELVRIPMAGGVESLNVAVAAAILLY 256


                 ....*....
gi 495147130 160 EAQRQRQNA 168
Cdd:COG0566  257 EAARQRRAK 265
SpoU-like_rRNA-MTase cd18095
SAM-dependent rRNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 30-161 8.56e-37

SAM-dependent rRNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349968  Cd Length: 143  Bit Score: 126.00  E-value: 8.56e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130  30 PHNVSAIIRTADAVGVHEV----HAVWPGNR--MRtmasSAAGSNSWVEVKTHRNISDAVNHLKARGMQILATHLsDKAV 103
Cdd:cd18095   11 PGNLGTIIRTAAAFGVDGVilskGTVDPYNPkvVR----ASMGALFRLPIIRVDDLEELLEELKEAGYKVVAADL-DGGS 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 495147130 104 DFREIDYTRPTCILMGQEKTGITEEALSLADQDIIIPMTGMVQSLNVSVASALILYEA 161
Cdd:cd18095   86 SLYDLDLPKPVALVLGNEGNGLSDELLELCDKRVTIPMSGGVESLNVAVAAAILLYEL 143
SpoU-like cd18097
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 20-161 9.32e-37

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349970  Cd Length: 144  Bit Score: 126.14  E-value: 9.32e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130  20 LTVCMEQVHKPHNVSAIIRTADAVGVHEVH----AVWPGNRmrTMASSAAGSNSWVEVKTHRNISDAVNHLKARGMQILA 95
Cdd:cd18097    1 LVVVLDNLRSAHNVGSIFRTADAAGVEKIYlcgyTPTPPHP--KVAKTALGAEESVPWEHFEDTLEAVRALKARGYTIIA 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 495147130  96 THLSDKAVDFREIDYTRPTCILMGQEKTGITEEALSLADQDIIIPMTGMVQSLNVSVASALILYEA 161
Cdd:cd18097   79 LETTENSVPLHEARLPRPLALVLGNEVRGVSPEVLALCDAVVEIPMFGRKNSLNVAVAAAVALYEL 144
SpoU-like_RlmB cd18103
SAM-dependent rRNA methylase related to RlmB; 23S rRNA-M2G2251-MTase RlmB catalyzes the ...
 22-161 1.45e-36

SAM-dependent rRNA methylase related to RlmB; 23S rRNA-M2G2251-MTase RlmB catalyzes the methylation of guanosine 2251, a modification conserved in the peptidyltransferase domain of 23S rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349976  Cd Length: 143  Bit Score: 125.57  E-value: 1.45e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130  22 VCMEQVHKPHNVSAIIRTADAVGVHEVhaVWPGNRM----RTMASSAAGSNSWVEVKTHRNISDAVNHLKARGMQILATH 97
Cdd:cd18103    3 LILDGITDPHNLGAIIRSAEAFGVDGV--IIPKRRSapltPTVAKASAGALEHLPIARVTNLARALEELKEAGFWIYGAD 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 495147130  98 LSDkAVDFREIDYTRPTCILMGQEKTGITEEALSLADQDIIIPMTGMVQSLNVSVASALILYEA 161
Cdd:cd18103   81 GEA-EKSLYDVDLTGPLALVLGSEGKGLRRLVLKNCDFLVKIPMAGKVDSLNVSVAAGIILYEI 143
SpoU-like_RNA-MTase cd18104
SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 25-165 5.03e-33

SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349977  Cd Length: 146  Bit Score: 116.53  E-value: 5.03e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130  25 EQVHKPHNVSAIIRTADAVGVHEVHAVWPG------NRMRtmasSAAGSNSWVEVkTHRNISDAVNHLKARGMQILATHL 98
Cdd:cd18104    6 EGLEKPGNLGAILRSADAAGADAVILCDPKtdlfnpNVIR----ASLGAVFTLPV-AEASSEETLAWLKENKIRILATTP 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 495147130  99 sDKAVDFREIDYTRPTCILMGQEKTGITEEALSLADQDIIIPMTGMVQSLNVSVASALILYEAQRQR 165
Cdd:cd18104   81 -KAEKLYYEADLRGPIAIVVGSESEGLSEFWLKAADERVRIPMAGQADSLNVSVAAAILLYEALRQR 146
SpoU-like_family cd18082
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 21-161 7.79e-32

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349955  Cd Length: 145  Bit Score: 113.47  E-value: 7.79e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130  21 TVCMEQVHKPHNVSAIIRTADAVGVHEVH------AVWPGNRMRTmassAAGSNSWVEVKTHRNISDAVNHLKARGMQIL 94
Cdd:cd18082    1 HLVLDNIRSPGNIGSIFRTADAFGVEKIYlvgptaDIFDPKAKRT----SRGTHFSVPYERVDNFEEYLKSLKEEGYPLI 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495147130  95 ATHLSDKAVDFREIDY--TRPTCILMGQEKTGITEEALSLADQDIIIPMTGMVQSLNVSVASALILYEA 161
Cdd:cd18082   77 GLELTDGSIPLSEFKFkkPKKIALIFGNERSGLSPELLALCDYTVHIPMSGKNSSLNVSVATGIALYEF 145
SpoU-like cd18096
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 22-160 7.69e-29

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349969  Cd Length: 140  Bit Score: 105.38  E-value: 7.69e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130  22 VCMEQVHKPHNVSAIIRTADAVGVHEVHAVwpgNRMRTMASSAAGSNSWVEVKTHRNISDAVNHLKARGMQILATHLSDK 101
Cdd:cd18096    3 LVLHNVAKRHNIGTIVRSANAFGVKEVHLV---GRRKFNPFGAMGTDRHVKFRHFDTLAEAKEYLKERGIRLVGVEIVPG 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130 102 AVDFREIDYTRPTCILMGQEKTGITEEALSLADQDIIIPMTG-MVQSLNVSVASALILYE 160
Cdd:cd18096   80 AEPIETHPFPGDTAFVLGNEGTGLSDEQLAICDGFVYIPQYGsGTASLNVSVAASIVLHH 139
SpoU_methylas_C pfam12105
SpoU, rRNA methylase, C-terminal; This domain is found in bacteria. This domain is about 60 ...
 163-218 6.63e-28

SpoU, rRNA methylase, C-terminal; This domain is found in bacteria. This domain is about 60 amino acids in length. This domain is found in association with pfam00588. This domain has a conserved LFE sequence motif. Some members of the Pfam family SpoU_methylase, pfam00588, carry this very distinctive sequence region at their extreme C-terminus. The exact function of this region is not known.


Pssm-ID: 463460  Cd Length: 54  Bit Score: 100.32  E-value: 6.63e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 495147130  163 RQRQNAGMYQRANstLPEEEQQRLLFEGGYPVLAKVAKRKGLPYPRVNEHGEIDAP 218
Cdd:pfam12105   1 RQRQAAGMYDRPR--LSEEEYQRLLFEWGYPVLAKLCRRKGLPYPALDEDGEILAD 54
rRNA_methyl_3 TIGR00186
rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases ...
 30-165 2.48e-23

rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129290 [Multi-domain]  Cd Length: 237  Bit Score: 93.95  E-value: 2.48e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130   30 PHNVSAIIRTADAVGVHEVhaVWPGNRM----RTMASSAAGSNSWVEVKTHRNISDAVNHLKARGMQILATHLSDKAVDF 105
Cdd:TIGR00186 101 PHNLGAILRTAEAFGVDGV--ILPKRRSaplnSTVVKTSSGAVEYVPLARVTNLSRTITKLKESGFWTVGTDLDAQDTLY 178

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130  106 REIDyTRPTCILMGQEKTGITEEALSLADQDIIIPMTGMVQSLNVSVASALILYEAQRQR 165
Cdd:TIGR00186 179 QVKL-TKPLALVVGNEGEGVSRLIKENCDFLIKIPMAGKVDSLNVSVAAGILLFEIKRQR 237
SpoU-like_TRM3-like cd18091
SAM-dependent tRNA methylase related to TRM3; Yeast tRNA (guanosine(18)-2'-O) ...
 20-160 8.19e-23

SAM-dependent tRNA methylase related to TRM3; Yeast tRNA (guanosine(18)-2'-O)-methyltransferase TRM3 catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in various tRNAs. TRM3 is similar to C-terminal domain of TAR (HIV-1) RNA binding protein 1 (TARBP1), a protein binding to TAR, which functions as a RNA regulatory signal by forming a stable stem-loop structure to which transactivator protein Tat binds. The role of TARBP1 is believed to be to disengage RNA polymerase II from TAR during transcriptional elongation. TRM3 and the C-terminal methyltransferase domain of TARBP1 are members of the SPOUT methyltransferase superfamily.


Pssm-ID: 349964  Cd Length: 145  Bit Score: 89.90  E-value: 8.19e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130  20 LTVCMEQVHKPHNVSAIIRTADAVGVHEVHAvwPGNRM------RTMASSAAgsnSWVEVKTHR--NISDAVNHLKARGM 91
Cdd:cd18091    1 LIVVASLIDKPPNLGGLCRTCEIFGVSKLVL--PNLAVvedkqfKALSVSAE---KWLPIEEVKpeDLLPYLKEKKQEGY 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495147130  92 QILATHLSDKAVDFREIDYTRPTCILMGQEKTGITEEALSLADQDIIIPMTGMVQSLNVSVASALILYE 160
Cdd:cd18091   76 TIVGLEQTANSVSLHDFQFPKKTVLVLGNEKEGIPAELLSLLDVCVEIPQLGVIRSLNVHVSGAIAIYE 144
PRK11181 PRK11181
23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB;
11-165 3.04e-19

23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB;


Pssm-ID: 183021 [Multi-domain]  Cd Length: 244  Bit Score: 83.09  E-value: 3.04e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130  11 EMLARRQPDLTVCMEQVHKPHNVSAIIRTADAVGVHEVhaVWPGNR-------MRTMASSAAGSNSWVEVKthrNISDAV 83
Cdd:PRK11181  87 DLLASLEQPFLLILDGVTDPHNLGACLRSADAAGVHAV--IVPKDRsaqlnatAKKVACGAAETVPLIRVT---NLARTM 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130  84 NHLKARGMQIL-----ATHlsdkavDFREIDYTRPTCILMGQEKTG---ITEEAlslADQDIIIPMTGMVQSLNVSVASA 155
Cdd:PRK11181 162 RMLQEKNIWIVgtageADH------TLYQSKLTGPLALVMGAEGEGmrrLTREH---CDELISIPMAGSVSSLNVSVATG 232

                        170
                 ....*....|
gi 495147130 156 LILYEAQRQR 165
Cdd:PRK11181 233 ICLFEAVRQR 242
SpoU-like_AviRb cd18107
SAM-dependent rRNA methylase related to AviRb; AviRb from Streptomyces viridochromogenes ...
 29-161 7.76e-18

SAM-dependent rRNA methylase related to AviRb; AviRb from Streptomyces viridochromogenes methylates the 2'-O atom of U2479 of the 23S ribosomal RNA. AviRb is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349980  Cd Length: 148  Bit Score: 77.04  E-value: 7.76e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130  29 KPHNVSAIIRTADAVGVHEV----HAVWPGNRMRTMASSAA-GSNSWVEVKTHRNISDAVNHLKARG--MQILATHLSDK 101
Cdd:cd18107   10 SPGNLGTIIRSADALGAHGLvvtgHAADVYDPKTIRASTGSlFSLPIVRVPSNRELEDWVEARKARGtpLQLVGTDEHGD 89

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130 102 aVDFREIDYTRPTCILMGQEKTGITEEALSLADQDIIIPMTGMVQSLNVSVASALILYEA 161
Cdd:cd18107   90 -HQIADHDFTRPTLLLIGNETAGLSAAWRELCDETVSIPMAGSASSLNAACAASIFLYEA 148
SpoU-like_TrmL cd18094
SAM-dependent tRNA methylase related to TrmL; tRNA (Um34/Cm34) methyltransferase TrmL ...
 30-164 2.71e-17

SAM-dependent tRNA methylase related to TrmL; tRNA (Um34/Cm34) methyltransferase TrmL catalyzes the methyl transfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH at position 34 in both tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349967  Cd Length: 145  Bit Score: 75.57  E-value: 2.71e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130  30 PHNVSAIIRTADAVGVhEVHAVWP-G-----NRMRTmassaAGSNSW--VEVKTHRNISDAVNHLKARGMqILATHLSDK 101
Cdd:cd18094   10 PQNTGNIARTCAATGA-RLHLIEPlGfslddKRLKR-----AGLDYWdhVDLTVHDSWEAFLEALPPGRL-FLFTTKGTK 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 495147130 102 AVDfrEIDYTRPTCILMGQEKTGITEEAL-SLADQDIIIPMTGMVQSLNVSVASALILYEAQRQ 164
Cdd:cd18094   83 PYT--DFDFKPGDYLVFGRESTGLPEEILdAFPDRRLRIPMRPKVRSLNLSNSVAIVLYEALRQ 144
PRK10864 PRK10864
putative methyltransferase; Provisional
 19-166 5.45e-16

putative methyltransferase; Provisional


Pssm-ID: 236779 [Multi-domain]  Cd Length: 346  Bit Score: 75.59  E-value: 5.45e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130  19 DLTVCMEQVHKPHNVSAIIRTADAVGV-----HEVHAVWPGNRMRTmassAAGSNSWVEVKTHRNISDAVNHLKARGMQI 93
Cdd:PRK10864 198 DCVLALEDVGNPHNLGGIMRSCAHFGVkgvvvQDAALLESGAAIRT----AEGGAEHVQPITGDSFVDVLDDFRQAGYTI 273

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 495147130  94 LATHlSDKAVDFREIDYTRPTCILMGQEKTGITEEALSLADQDIIIPMTGMVQSLNVSVASALILYEAQRQRQ 166
Cdd:PRK10864 274 VTTS-SHKGTPLFKASLPAKMVLVLGQEYDGLSDAARQQGDLSVSIDGTGNVESLNVSVATGVLLAEWWRQNK 345
SpoU-like_MRM1 cd18105
SAM-dependent rRNA methylase related to MRM1; MRM1 catalyzes the methylation of 2'-O-ribose ...
 20-160 2.63e-15

SAM-dependent rRNA methylase related to MRM1; MRM1 catalyzes the methylation of 2'-O-ribose residues G1145 to GmG residue of the mitochondrial 16S rRNA. MRM1 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349978  Cd Length: 158  Bit Score: 70.63  E-value: 2.63e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130  20 LTVCMEQVHKPHNVSAIIRTADAVGVHEVhAVWPGNRMR---TMASSAAGSNSWVEVKTHRNISDAVNHLKARGMQILAT 96
Cdd:cd18105    1 LWLLLDEITDPQNLGAILRSAYFLGVDGV-VVSSKNSAPlspVVSKASAGALELMPIYSVDNLASFLKSSKENGWKVVGT 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 495147130  97 HLSD---------KAVDFREIDYTRPTCILMGQEKTGITEEALSLADQDIIIPM-----TGMVQSLNVSVASALILYE 160
Cdd:cd18105   80 SAPPsassdkktiPANELSELLLEKPTILVLGNEGRGLRTNIKNLCDYLVSIPGgrsaeNPGVDSLNVSVAAGILLHS 157
TrmL COG0219
tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain [Translation, ...
 30-170 1.25e-14

tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain [Translation, ribosomal structure and biogenesis]; tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 439989  Cd Length: 153  Bit Score: 68.52  E-value: 1.25e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130  30 PHNVSAIIRTADAVGVhEVHAVWP-G-----NRMRTmassaAGSNSW--VEVKTHRNISDAVNHLKARgmQILAthLSDK 101
Cdd:COG0219   12 PQNTGNIIRLCAATGA-RLHLIEPlGfslddKKLKR-----AGLDYWelVDLTVHDSWEAFLEALPGG--RLFL--FTTK 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 495147130 102 A-VDFREIDYtRPTCILM-GQEKTGITEEAL-SLADQDIIIPMTGMVQSLNVSVASALILYEAQRQRQNAGM 170
Cdd:COG0219   82 GtKPYTDVDY-QPGDVLLfGRETAGLPEEVLaAPADQRLRIPMRPGVRSLNLSNAVAIVLYEALRQLGFPGL 152
SpoU-like_RNMTL1 cd18106
SAM-dependent rRNA methylase related to RNMTL1; RNMTL1 (also known as HC90, MRM3 and RMTL1) ...
 20-161 2.34e-13

SAM-dependent rRNA methylase related to RNMTL1; RNMTL1 (also known as HC90, MRM3 and RMTL1) catalyzes the methylation of 2'-O-ribose residues G1370 to GmG residue of the mitochondrial 16S rRNA. RNMTL1 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349979  Cd Length: 148  Bit Score: 64.97  E-value: 2.34e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130  20 LTVCMEQVHKPHNVSAIIRTADAVGVHEVHA------VWPGNRMRtmassaAGSNSWVEVKTHRNIS-DAVNHLKARGMQ 92
Cdd:cd18106    1 LTVICDNIRDPGNLGSILRSAAAAGCSKVLLtkgcvdPWEPKVLR------AGAGAHFRLPIYGNLSwDDIPNYLPDDSK 74

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 495147130  93 ILATHLSDKAVDFREIDYTR-PTCILMGQEKTGITEEALSLADQD----IIIPMTGMVQSLNVSVASALILYEA 161
Cdd:cd18106   75 VFLADNNLPVQPYDSIDYCSgPIVLVIGGETHGVSPEAYKLAHSTggsrVHIPLANGVDSLNSAVAASILLFEM 148
SpoU-like_RNA-MTase cd18109
SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 20-160 3.46e-13

SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349982  Cd Length: 141  Bit Score: 64.48  E-value: 3.46e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130  20 LTVCMEQVHKPHNVSAIIRTADAVGVHEVHA----VWPGNR---MRTMASSAAgsnswveVKTHR-NISDAVNHLKARGM 91
Cdd:cd18109    1 LTLALDGIQDPGNLGTIIRTADWFGIRQIICspdtVDPYNPkvvQASMGSIFR-------VQIHYtDLPALLAELKKAFP 73

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130  92 qILATHLSDKAVdfREIDYTRPTCILMGQEKTGITEEALSLADQDIIIPMTG-MVQSLNVSVASALILYE 160
Cdd:cd18109   74 -VYGADLDGENL--YEFTLPEKGILVMGNEGHGISPEVLKLLTHRLTIPRYGkGAESLNVAVATAILLSE 140
SpoU-like cd18098
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 22-159 6.87e-11

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349971  Cd Length: 138  Bit Score: 58.04  E-value: 6.87e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130  22 VCMEQVHKPHNVSAIIRTADAVGVHEVHAVwpGNRMRTMASSAAGSNSW-----VEVKThrnISDAVNHLkARGMQILAT 96
Cdd:cd18098    3 IGIENPKTPKNVGTLWRAAGCLGASFVFTI--GARYKRRKQSTDTSKAWrhiplFHYDD---LEDLAEPL-PFGAVLVAV 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 495147130  97 HLSDKAVDFreIDYTRP--TCILMGQEKTGITEEALSLADQDIIIPMTGmvqSLNVSVASALILY 159
Cdd:cd18098   77 ELTEGATPL--PDFKHPdrAVYLLGPEDGGLPQEVLARCHHVVYLPTRG---SLNVAVAGSIVLY 136
SpoU-like_TrmJ cd18093
SAM-dependent tRNA methylase related to TrmJ; tRNA methyltransferase TrmJ catalyzes the methyl ...
 30-160 3.12e-10

SAM-dependent tRNA methylase related to TrmJ; tRNA methyltransferase TrmJ catalyzes the methyl transfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH at position 32 in both tRNASer1 and tRNAGln2. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349966  Cd Length: 153  Bit Score: 56.74  E-value: 3.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130  30 PHNVSAIIRTADAVGVHEVHAV----WPGNRMRTMAssAAGSNSWVE-VKTHRNISDAVNHL--------KARGMQILAT 96
Cdd:cd18093   11 PGNIGAVARAMKNFGLSDLRLVnprcDDPEEAARAL--ASGAEDVLEnAKVYDTLEEALADCdlvvattaRPRGLRRPLL 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 495147130  97 HLSDKAVDFREIDYTRPTCILMGQEKTGITEEALSLADQDIIIPMTGMVQSLNVSVASALILYE 160
Cdd:cd18093   89 TPRELAELLKEHAAGGKVALVFGREDSGLTNEELALCDLLVTIPTNPEYPSLNLAQAVAIVLYE 152
SpoU-like_NHR cd18108
Nosiheptide-resistance methyltransferase (NHR); Nosiheptide-resistance methyltransferase (NHR) ...
 32-160 2.59e-09

Nosiheptide-resistance methyltransferase (NHR); Nosiheptide-resistance methyltransferase (NHR) confers resistance to the thiazole antibiotic nosiheptide via catalyzing 2'O-methylation of 23S rRNA at the nucleotide A1067. NHR is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349981  Cd Length: 144  Bit Score: 54.02  E-value: 2.59e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130  32 NVSAIIRTADAVGVHEVHAVWPG-----NRMRTMASSAAGSNSWVEVKTHRnisDAVNHLKARGMQIlATHLSDKAVDFR 106
Cdd:cd18108   13 NIGAIVRTSLALGAAGIVLVDSDlatvaDRRLLRASRGYVFSLPVVLADRE---EAVAFLRDNDIPL-MTLDADGDVPVK 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 495147130 107 EI-DYTRPTCILMGQEKTGITEEALSLADQDIIIPMTGMVQSLNVSVASALILYE 160
Cdd:cd18108   89 ELgDRPDRLALVFGSEKGGPSGLFEEAAAGTVSIPMSSSTESLNVSVSAGIALHE 143
SPOUT_MTase cd07060
SPOUT superfamily of SAM-dependent RNA methyltransferases; The SPOUT (SpoU-TrmD) ...
 21-161 3.41e-09

SPOUT superfamily of SAM-dependent RNA methyltransferases; The SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, also known as class IV methyltransferase family, is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot. Members of the SPOUT superfamily that have been characterized functionally are involved in post-transcriptional RNA modification by catalyzing methylation of the 2-OH group of ribose, the N-1 atom of guanosine 37 in tRNA, or the N-3 atom of uridine 1498 in 16S rRNA.


Pssm-ID: 349952  Cd Length: 99  Bit Score: 52.44  E-value: 3.41e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130  21 TVCMEQVHKPHNVSAIIRTADAVGVHEVHAVwpgnrmrtmassaagsnswvevkthrnisdavnhlkargmQILATHLSD 100
Cdd:cd07060    1 RIVIDEKKIPEKVDKIIRAALAEYAKRLSIY----------------------------------------GIVTLSSEG 40

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 495147130 101 KAVDFRE--IDYTRPTCILMGQEKTGITEEALSLADQDIIIPMtgmvQSLNVSVASALILYEA 161
Cdd:cd07060   41 FAVKISEleISGGSNIAFVIGGEYGGLEESARALADEPISISS----MTLSAELAATILLEQL 99
TrmJ COG0565
tRNA C32,U32 (ribose-2'-O)-methylase TrmJ or a related methyltransferase [Translation, ...
 51-189 1.17e-05

tRNA C32,U32 (ribose-2'-O)-methylase TrmJ or a related methyltransferase [Translation, ribosomal structure and biogenesis]; tRNA C32,U32 (ribose-2'-O)-methylase TrmJ or a related methyltransferase is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440331 [Multi-domain]  Cd Length: 237  Bit Score: 44.72  E-value: 1.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130  51 VWPGNRMRTMASSAagsnSWV--EVKTHRNISDAV---NHL-----KARGMQILATHLSDKAVDFREIDYTRPTCILMGQ 120
Cdd:COG0565   39 GWPDEEARAMASGA----DDVleNARVVDTLEEALadcDLVvgttaRPRELRKPVLTPREAAEELLARAAGGKVALVFGR 114

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130 121 EKTGITEEALSLADQDIIIPMTGMVQSLNVSVASALILYEAQRQRQNAGMYQRANST-LPEEEQQRLLFE 189
Cdd:COG0565  115 ERSGLTNEELALCDALVTIPTNPEYPSLNLAQAVQVVAYELRKAALEAPPLPPPPEPePATAEELEGLYE 184
PRK10358 PRK10358
tRNA (uridine(34)/cytosine(34)/5-carboxymethylaminomethyluridine(34)-2'-O)-methyltransferase ...
 102-174 7.41e-05

tRNA (uridine(34)/cytosine(34)/5-carboxymethylaminomethyluridine(34)-2'-O)-methyltransferase TrmL;


Pssm-ID: 182406  Cd Length: 157  Bit Score: 41.90  E-value: 7.41e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 495147130 102 AVDFREIDYtrptcILMGQEKTGITEEALSL--ADQDIIIPMTGMVQSLNVSVASALILYEAQRQRQNAGMYQRA 174
Cdd:PRK10358  88 AVSYQDGDY-----LMFGPETRGLPASILDAlpAEQKIRIPMMPDSRSMNLSNAVSVVVYEAWRQLGYPGAVLRD 157
rRNA_methyl_1 TIGR00050
RNA methyltransferase, TrmH family, group 1; This is part of the trmH (spoU) family of ...
 113-189 2.55e-04

RNA methyltransferase, TrmH family, group 1; This is part of the trmH (spoU) family of S-adenosyl-L-methionine (AdoMet)-dependent methyltransferases, and is now characterized, in E. coli, as a tRNA:Cm32/Um32 methyltransferase. It may be named TrMet(Xm32), or TrmJ, according to the nomenclature style chosen [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 272876 [Multi-domain]  Cd Length: 233  Bit Score: 40.85  E-value: 2.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495147130  113 PTCILMGQEKTGITEEALSLADQDIIIPMTGMVQSLNVSVASALILYE---AQRQRQNAgmyqRANSTLPEEEQQRLLFE 189
Cdd:TIGR00050 105 KVALVFGREDSGLTNEELQKCHVLVSIPTSEEYPSLNLSHAVAVILYElrmAWLAQQEN----LSEMPYATVDDLELLLE 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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