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Conserved domains on  [gi|495145585|ref|WP_007870392|]
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MULTISPECIES: MarR family winged helix-turn-helix transcriptional regulator [Cronobacter]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
5-134 4.56e-27

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 97.73  E-value: 4.56e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495145585   5 QQAFHLLRQLFQQHTAQWQLALPE--LTKPQYAVLRSIAENPGIEQVALTEAAVSTKATLAEMLSRMESRGLVRRESAPE 82
Cdd:COG1846   10 ERLGLLLRRLARALRRALDRALAElgLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPE 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 495145585  83 DKRRRFIYLTPEGEALLHASIPKGDAVDEAFLGKLNAEERALFAALITRMID 134
Cdd:COG1846   90 DRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAE 141
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
5-134 4.56e-27

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 97.73  E-value: 4.56e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495145585   5 QQAFHLLRQLFQQHTAQWQLALPE--LTKPQYAVLRSIAENPGIEQVALTEAAVSTKATLAEMLSRMESRGLVRRESAPE 82
Cdd:COG1846   10 ERLGLLLRRLARALRRALDRALAElgLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPE 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 495145585  83 DKRRRFIYLTPEGEALLHASIPKGDAVDEAFLGKLNAEERALFAALITRMID 134
Cdd:COG1846   90 DRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAE 141
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
29-122 9.79e-21

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 80.33  E-value: 9.79e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495145585    29 LTKPQYAVLRSIAENPGIEQVALTEAAVSTKATLAEMLSRMESRGLVRRESAPEDKRRRFIYLTPEGEALLHASIPKGDA 108
Cdd:smart00347   8 LTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLEARSE 87

                           90
                   ....*....|....
gi 495145585   109 VDEAFLGKLNAEER 122
Cdd:smart00347  88 TLAELLAGLTAEEQ 101
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 29-85 1.13e-10

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 53.32  E-value: 1.13e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 495145585   29 LTKPQYAVLRSIAENPGIEQVALTEAAVSTKATLAEMLSRMESRGLVRRESAPEDKR 85
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRR 57
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
28-133 1.93e-05

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 41.81  E-value: 1.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495145585  28 ELTKPQYAVLRSIAENPGIEQVALTEAAVSTKATLAEMLSRMESRGLVRRESAPEDKRRRFIYLTPEGEAL---LHASIp 104
Cdd:PRK11512  37 DITAAQFKVLCSIRCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDKRGVLVKLTTSGAAIceqCHQLV- 115

                         90       100
                 ....*....|....*....|....*....
gi 495145585 105 kGDAVDEAFLGKLNAEERALFAALITRMI 133
Cdd:PRK11512 116 -GQDLHQELTKNLTADEVATLEHLLKKVL 143
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
5-134 4.56e-27

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 97.73  E-value: 4.56e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495145585   5 QQAFHLLRQLFQQHTAQWQLALPE--LTKPQYAVLRSIAENPGIEQVALTEAAVSTKATLAEMLSRMESRGLVRRESAPE 82
Cdd:COG1846   10 ERLGLLLRRLARALRRALDRALAElgLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPE 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 495145585  83 DKRRRFIYLTPEGEALLHASIPKGDAVDEAFLGKLNAEERALFAALITRMID 134
Cdd:COG1846   90 DRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAE 141
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
29-122 9.79e-21

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 80.33  E-value: 9.79e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495145585    29 LTKPQYAVLRSIAENPGIEQVALTEAAVSTKATLAEMLSRMESRGLVRRESAPEDKRRRFIYLTPEGEALLHASIPKGDA 108
Cdd:smart00347   8 LTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLEARSE 87

                           90
                   ....*....|....
gi 495145585   109 VDEAFLGKLNAEER 122
Cdd:smart00347  88 TLAELLAGLTAEEQ 101
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 29-85 1.13e-10

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 53.32  E-value: 1.13e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 495145585   29 LTKPQYAVLRSIAENPGIEQVALTEAAVSTKATLAEMLSRMESRGLVRRESAPEDKR 85
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRR 57
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 29-86 9.09e-10

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 51.05  E-value: 9.09e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 495145585   29 LTKPQYAVLRSIAENPGIEQVALTEAAVSTKATLAEMLSRMESRGLVRRESAPEDKRR 86
Cdd:pfam12802   3 LTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
HTH_27 pfam13463
Winged helix DNA-binding domain;
29-95 3.09e-07

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 44.59  E-value: 3.09e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 495145585   29 LTKPQYAVLRSI-AENPGIEQVALTEAAVSTKATLAEMLSRMESRGLVRRESAPEDKRRRFIYLTPEG 95
Cdd:pfam13463   1 LTRLEALILHNIgHRGDPKTLADICFRLNVEDSHVSYSLKKLTEAGLVEREGSEEDGRETRVRLTAKG 68
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 24-96 1.64e-06

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 42.98  E-value: 1.64e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 495145585  24 LALPELTKPQYAVLRSIAENPG-IEQVALTEAAVSTKATLAEMLSRMESRGLVRREsapEDKRRRFIYLTPEGE 96
Cdd:COG2512    8 LLYPELLEDERRVLELLRENGGrMTQSEIVKETGWSKSKVSRLLSRLEERGLIEKE---RVGRENVVELPEDEP 78
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
28-133 1.93e-05

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 41.81  E-value: 1.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495145585  28 ELTKPQYAVLRSIAENPGIEQVALTEAAVSTKATLAEMLSRMESRGLVRRESAPEDKRRRFIYLTPEGEAL---LHASIp 104
Cdd:PRK11512  37 DITAAQFKVLCSIRCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDKRGVLVKLTTSGAAIceqCHQLV- 115

                         90       100
                 ....*....|....*....|....*....
gi 495145585 105 kGDAVDEAFLGKLNAEERALFAALITRMI 133
Cdd:PRK11512 116 -GQDLHQELTKNLTADEVATLEHLLKKVL 143
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
58-98 1.06e-04

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 39.42  E-value: 1.06e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 495145585  58 TKATLAEMLSRMESRGLVRREsapedkRRRFIYLTPEGEAL 98
Cdd:COG1321   37 SPPSVTEMLKKLEEKGLVEYE------PYGGITLTEEGREL 71
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
58-99 1.71e-03

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 35.61  E-value: 1.71e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 495145585  58 TKATLAEMLSRMESRGLVRRESAPEdKRRRFIY-LTPEGEALL 99
Cdd:COG1733   49 SQKMLTQRLRELEEDGLVERTVYPE-VPPRVEYsLTEKGRSLL 90
PadR COG1695
DNA-binding transcriptional regulator, PadR family [Transcription];
33-101 4.17e-03

DNA-binding transcriptional regulator, PadR family [Transcription];


Pssm-ID: 441301  Cd Length: 102  Bit Score: 34.53  E-value: 4.17e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495145585  33 QYAVLRSIAENPG--------IEQVALTEAAVSTkATLAEMLSRMESRGLVR-RESAPEDKRRRFIY-LTPEGEALLHA 101
Cdd:COG1695   11 ELLILALLAEGPMygyeiikeLEERSGGFWKVSE-GTLYPALKRLEKEGLVEsEWEESEGGPRRKYYrLTEAGREELAE 88
PRK13777 PRK13777
HTH-type transcriptional regulator Hpr;
56-109 5.10e-03

HTH-type transcriptional regulator Hpr;


Pssm-ID: 237501  Cd Length: 185  Bit Score: 35.40  E-value: 5.10e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 495145585  56 VSTKATLAEMLsrmESRGLVRRESAPEDKRRRFIYLTPEGEALLHASI----PKGDAV 109
Cdd:PRK13777  73 VSTAFNFSKKL---EERGYLTFSKKEDDKRNTYIELTEKGEELLLETMeeydPENNSV 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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