|
Name |
Accession |
Description |
Interval |
E-value |
| lacY |
PRK09528 |
galactoside permease; Reviewed |
4-420 |
0e+00 |
|
galactoside permease; Reviewed
Pssm-ID: 236549 Cd Length: 420 Bit Score: 632.32 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 4 TVCTRKHNPNFWIFGLFFFFYFFIMATCFPFLPIWLSDVIGLNKTDTGIVFSCMSLFAIAFQPVLGVISDKLGLKKHLLW 83
Cdd:PRK09528 2 ATMYYLKNPNYWIFSLFFFFFFFIWSSWFSFFPIWLHDINGLSGTDTGIIFSANSLFALLFQPLYGLISDKLGLKKHLLW 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 84 IITTLLVLFAPFFLWVFGPLLKVNIWLGALMGGLYIGFCFSSGAGAIEAYIERVSRSSGFEYGKARMFGCLGWGLCASTA 163
Cdd:PRK09528 82 IISGLLVLFGPFFIYVFAPLLQYNILLGAIVGGIYLGFGFLAGAGAIEAYIERVSRRSGFEYGRARMWGSLGWALCAFIA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 164 GMLFNVNPAIVFWMGSSAALVLMGLLLFARPRANQTAQVMNALGANQPQVTAKMALGLFRLPKLWMFILYVVGVACVYDV 243
Cdd:PRK09528 162 GILFNINPQINFWLGSGSALILLVLLFFAKPDAPSTAKVANALGANASAVSLKDALALLKLPKFWFLVLYVIGVACFYDV 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 244 FDQQFATFFKSFFPTPQAGTQAFGFATTAGELCNAIIMFCSPWIINRIGAKNTLLIAGTIMATRIIGSAFATNVYEIVAL 323
Cdd:PRK09528 242 FDQQFPNFFASFFATPEQGTRVFGYLNSFQVFLEALIMFFAPFIINRIGAKNALLLAGTIMAVRIIGSGFATGPLEVSIL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 324 KMLHALEVPFLLVGAFKYITGVFDTRLSATIYLIGFQFAKQMAAIFLSAFAGTMYDRIGFQDTYLILGSFVLAITVVSAF 403
Cdd:PRK09528 322 KLLHAFEVPFLLVGVFKYITLNFDVRLSATIYLVGFQFAKQLGAVFLSTLAGNLYDSIGFQGTYLILGGIVLLFTLISVF 401
|
410
....*....|....*..
gi 495055146 404 TLTNTRQAVVSEETVKA 420
Cdd:PRK09528 402 TLSGDRELSLLRRQVPE 418
|
|
| 2A0105 |
TIGR00882 |
oligosaccharide:H+ symporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
11-406 |
0e+00 |
|
oligosaccharide:H+ symporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 211613 Cd Length: 396 Bit Score: 569.76 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 11 NPNFWIFGLFFFFYFFIMATCFPFLPIWLSDVIGLNKTDTGIVFSCMSLFAIAFQPVLGVISDKLGLKKHLLWIITTLLV 90
Cdd:TIGR00882 1 NTNFWMFGLFFFLYFFIMSAYFPFFPIWLHDVNGLSKTDTGIVFSCISLFSILFQPLFGLISDKLGLKKHLLWIISGLLV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 91 LFAPFFLWVFGPLLKVNIWLGALMGGLYIGFCFSSGAGAIEAYIERVSRSSGFEYGKARMFGCLGWGLCASTAGMLFNVN 170
Cdd:TIGR00882 81 LFAPFFIYVFGPLLQSNILVGAIVGGLYLGFVFSAGAGAIEAYIEKVSRNSNFEYGKARMFGCVGWALCASIAGILFSID 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 171 PAIVFWMGSSAALVLMGLLLFARPRANQTAQVMNALGANQPQVTAKMALGLFRLPKLWMFILYVVGVACVYDVFDQQFAT 250
Cdd:TIGR00882 161 PQIVFWLGSGFALILMLLLMFAKPKAPSSATVANALGANASAFSLKLALELFRQRKFWMFVLYVVGVACVYDVFDQQFAN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 251 FFKSFFPTPQAGTQAFGFATTAGELCNAIIMFCSPWIINRIGAKNTLLIAGTIMATRIIGSAFATNVYEIVALKMLHALE 330
Cdd:TIGR00882 241 FFTSFFATPQQGTRVFGYVTTMGELLNALIMFCAPLIINRIGAKNALLIAGTIMSVRIIGSSFATTALEVVILKMLHAFE 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 495055146 331 VPFLLVGAFKYITGVFDTRLSATIYLIGFQFAKQMAAIFLSAFAGTMYDRIGFQDTYLILGSFVLAITVVSAFTLT 406
Cdd:TIGR00882 321 VPFLLVGCFKYITSQFDVRLSATIYLIGFQFAKQLAMIFLSTLAGNMYDSIGFQGAYLVLGCIVLLFTLISVFTLS 396
|
|
| LacY_symp |
pfam01306 |
LacY proton/sugar symporter; This family is closely related to the sugar transporter family. |
27-418 |
0e+00 |
|
LacY proton/sugar symporter; This family is closely related to the sugar transporter family.
Pssm-ID: 396050 Cd Length: 413 Bit Score: 547.44 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 27 IMATCFPFLPIWLSDVIGLNKTDTGIVFSCMSLFAIAFQPVLGVISDKLGLKKHLLWIITTLLVLFAPFFLWVFGPLLKV 106
Cdd:pfam01306 22 IMSAYFPFFPIWLHDVNHLSKTDTGIVFSCISLFSILFQPLFGLISDKLGLRKHLLWCITGLLVLFAPFFIYVFGPLLQS 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 107 NIWLGALMGGLYIGFCFSSGAGAIEAYIERVSRSSGFEYGKARMFGCLGWGLCASTAGMLFNVNPAIVFWMGSSAALVLM 186
Cdd:pfam01306 102 NILVGAIVGGVYLGFVFSAGAGAIEAYIEKVSRRSNFEYGKARMFGCVGWALCASIAGILFSIDPQIVFWLGSGFALILA 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 187 GLLLFARPRANQTAQVMNALGANQPQVTAKMALGLFRLPKLWMFILYVVGVACVYDVFDQQFATFFKSFFPTPQAGTQAF 266
Cdd:pfam01306 182 LLLMFAKPDKSSSAIVADALGANKSAFSLRLALELFRMPKFWVFVLYVVGVACVYDVFDQQFANFFTSFFATPQQGTRVF 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 267 GFATTAGELCNAIIMFCSPWIINRIGAKNTLLIAGTIMATRIIGSAFATNVYEIVALKMLHALEVPFLLVGAFKYITGVF 346
Cdd:pfam01306 262 GYVTTMGELLNALIMFCAPLIINRIGAKNALLIAGTIMSVRILGSSFATTALEVVILKMLHMFEVPFLLVGCFKYITSQF 341
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 495055146 347 DTRLSATIYLIGFQFAKQMAAIFLSAFAGTMYDRIGFQDTYLILGSFVLAITVVSAFTLTNTRQAVVSEETV 418
Cdd:pfam01306 342 DVRLSATIYLIGFQFSKQLAMILLSTLAGIMYDSIGFQGAYLVLGGIVLSFTLISVFTLSGSGPQILLPRPV 413
|
|
| MFS_LacY |
cd06172 |
LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY ... |
27-405 |
0e+00 |
|
LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY proton/sugar family (also called LacY/RafB family) symporters are integral membrane proteins responsible for the transport of specific beta-glucosides into the cell accompanied by the import of a proton. Members include lactose permease (LacY), raffinose permease (RafB), and sucrose permease, which facilitate the transport of beta-galactosides, raffinose, and sucrose, respectively. The prototypical member, LacY, contains 12 transmembrane helices connected by hydrophilic loops with both N and C termini on the cytoplasmic face. The LacY/RafB permease family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340862 [Multi-domain] Cd Length: 389 Bit Score: 522.95 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 27 IMATCFPFLPIWLSDVIGLNKTDTGIVFSCMSLFAIAFQPVLGVISDKLGLKKHLLWIITTLLVLFAPFFLWVFGPLLKV 106
Cdd:cd06172 14 IWSASFSFFPIWLTQINHLSGSETGIVFSANSLFALLFQPVYGLISDKLGLKKHLLWFISGLLVLFGPFFIFVYGPLLQS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 107 NIWLGALMGGLYIGFCFSSGAGAIEAYIERVSRSSGFEYGKARMFGCLGWGLCASTAGMLFNVNPAIVFWMGSSAALVLM 186
Cdd:cd06172 94 NILLGAIVGGIYLGFAFLAGCGAIESYIERVSRRFNFEYGRARMWGSLGWALAAFFAGILFNINPNINFWLGSGFALILL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 187 GLLLFARPRANQTAQvmnALGANQPQVTAKMALGLFRLPKLWMFILYVVGVACVYDVFDQQFATFFKSFFPTPQAGTQAF 266
Cdd:cd06172 174 LLLLFAKPEDSDTAA---AAGANASSVSLKDVLELFRMPKFWFFILFVIGVSCFYDVFDQQFPPYFTSLFATPEQGNRVF 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 267 GFATTAGELCNAIIMFCSPWIINRIGAKNTLLIAGTIMATRIIGSAFATNVYEIVALKMLHALEVPFLLVGAFKYITGVF 346
Cdd:cd06172 251 GYLNSAQVFLEAGMMFLAPLIVNRIGAKNGLLLAGTIMAVRIIGSGLATSPLEISILKLLHAFEVPLLLVSIFKYITSHF 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 495055146 347 DTRLSATIYLIGFQFAKQMAAIFLSAFAGTMYDRIGFQDTYLILGSFVLAITVVSAFTL 405
Cdd:cd06172 331 DTRLSATLYLVGFQFAKQLGAVVLSPLAGNLYDSIGFQQTYLVLGGIVLVFTLISVFTL 389
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
32-414 |
1.02e-19 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 90.33 E-value: 1.02e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 32 FPFLPIWLSDVIGLNKTDTGIVFSCMSLFAIAFQPVLGVISDKLGLKKhllWIITTLLVLFAPFFLWVFGPLLKVNIWLG 111
Cdd:COG2223 24 WSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRR---VLLIGLLLLGIGLLLLALAVSYWLLLLLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 112 ALmGGLYIGFCFSSGAGAIEAYIERVSRssGFEYGKARMFGCLGWGLCASTAGMLFN-VNPAIVFWMGSSAALVLM-GLL 189
Cdd:COG2223 101 LL-LGIGGGGSFAVGIALVSKWFPPDRR--GLALGLAAGGGNLGAAVAAFLAPLLIAaFGWRNAFLILGILLLVVAvLAW 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 190 LFARPRANQTAQVmnalganqPQVTAKMALGLFRLPKLWMFILYVVGVACVYDVFDQQFATFFKSFFPTPQAgtqAFGFA 269
Cdd:COG2223 178 LFLRDPPAGAAAA--------AKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAA---TAGLL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 270 TTAGELCNAIIMFCSPWIINRIGAKNTLLIAGTIMATRIIGSAFAT-NVYEIVALKMLHALEVPFLLVGAFKYITGVFDT 348
Cdd:COG2223 247 AALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALgSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPT 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 495055146 349 RLSATIYLIGFqFAKQMAAIFLSAFAGTMYDRIG-FQDTYLILGSFVLAITVVSAFTLTNTRQAVVS 414
Cdd:COG2223 327 KNAGAVYGLVG-AAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLYRRPRRAAAA 392
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
27-403 |
2.65e-18 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 85.71 E-value: 2.65e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 27 IMATCFPFLPIWLSDvIGLNKTDTGIVFSCMSLFAIAFQPVLGVISDKLGLKKHLLWIITTLLVLFAPFFLWVFGpllkv 106
Cdd:cd17335 12 ALGSLLPFLSVYLKQ-LGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSLFFVAQ----- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 107 NIWLGALMGGLYIgFCFSSGAGAIEAYIERVSRSSGFEYGKARMFGCLGWGLCASTAGMLFN-----VNPAIVFWMGSSA 181
Cdd:cd17335 86 IFWLLLLLVILGA-FFSAPVVPLVDSITLQYLGEERERYGKQRLWGSIGFGIAALLVGILIDrsstyKNYTIAFYVFAVL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 182 ALVLMGLLLFARPRANQTaqvmnalganQPQVTAKMALGLFRLPKLWMFILyvvgVACVYDVFDQQFATFFKSFFPTPQA 261
Cdd:cd17335 165 MLLALLLALKFPFRPKHP----------EPNENTGGLLALLRNPRVLAFLL----VAFLMGFGHGLIYSFLFWHLQDLGG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 262 GTQAFGFATTAGELCNAIIMFCSPWIINRIGAKNTLLIAGTIMATRIIGSAFATNVYEIVALKMLHALEVPFLLVGAFKY 341
Cdd:cd17335 231 SKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSY 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 495055146 342 ITGVFDTRLSAT----IYLIGFQFAKQMAAIflsaFAGTMYDRIGFQDTYLILGSFVLAITVVSAF 403
Cdd:cd17335 311 ASAAAPPGLRATaqglLQGLYFGLGGGLGSL----IGGYLYEAFGARTTFRFFAIAALAGLLAFFL 372
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
32-403 |
1.64e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 62.21 E-value: 1.64e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 32 FPFLPIWLSDvIGLNKTDTGIVFSCMSLFAIAFQPVLGVISDKLGLKKHLLW-----IITTLLVLFAPFFLWVFgpllkv 106
Cdd:cd17325 16 IPILPLYAES-LGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLgllllAVSTLLFAFATSYWQLL------ 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 107 niwLGALMGGLYIGFCFSSGAGAIEAYIERVSRSSGFeyGKARMFGCLGWGLCASTAGMLFNV-NPAIVFWMGSSAALVL 185
Cdd:cd17325 89 ---LARFLQGLASAAVWPAAMALIADIAPPEERGRAM--GIFSSAIGLGFLIGPLLGGLLADAlGYRAPFLVCAALALLA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 186 MGLLLFARPRANQTAqvmnALGANQPQVTAKMALGLFRLPKLWMFILYVVGVACVYDVFDQQFATFFKSFFptpQAGTQA 265
Cdd:cd17325 164 LVLALLLLPEPRPPP----NKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELG---GLSPAQ 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 266 FGFATTAGELCNAIIMFCSPWIINRIGAKNTLLIAGTIMATRIIGSAFATNVYEIVALKMLHALEVPFLLVGAFKYITGV 345
Cdd:cd17325 237 IGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADI 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 495055146 346 FDTRLSATIYLIgFQFAKQMAAIFLSAFAGTMYDRIGFQDTYLILGSFVLAITVVSAF 403
Cdd:cd17325 317 VPPEGRGTAMGL-FNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
33-401 |
1.46e-09 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 59.36 E-value: 1.46e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 33 PFLPIWLSDViGLNKTDTGIVFSCMSLFAIAFQPVLGVISDKLGLKKhLLWIITTLLVLFAPFFLWVFGPLLkvnIWLGA 112
Cdd:cd06174 17 PLLPALLQSF-GLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRP-VLLLGLLLFALGALLFAFAPSFWL---LLLGR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 113 LMGGLYIGFCFSSGAGAIEAYIERvsRSSGFEYGKARMFGCLGWGLCASTAGMLFNVNPAIVFWM--GSSAALVLMGLLL 190
Cdd:cd06174 92 FLLGLGSGLIDPAVLALIADLFPE--RERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVflIAAALALLAAILL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 191 FARPRANQTAQVMNalgaNQPQVTAKMALGLFRLPKLWMFILYVVGVACVYDVFDQQFATFFKSFFPTPQAGTQAFGFAT 270
Cdd:cd06174 170 LLVVPDPPESARAK----NEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 271 TAGELCNAIIMFCSPWIINR-IGAKNTLLIAGTIMATRIIGSAFATNVYEIVALKMLHALEVPFLLVGAFKYITGVFDTR 349
Cdd:cd06174 246 SLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPE 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 495055146 350 LSATIYLIGFQFAKQMAAIFLSAFAGTMYDRIGFQDTYLILGSFVLAITVVS 401
Cdd:cd06174 326 IRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
7-193 |
5.49e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 57.59 E-value: 5.49e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 7 TRKHNPNFWIFGLFFFFYFFIMATCFPFLPIWLSDVIGLNKTDTGIVFSCMSLFAIAFQPVLGVISDKLGLKKhllWIIT 86
Cdd:cd17325 194 LLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKP---LILI 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 87 TLLVLFAPFFLWVFGPLLkVNIWLGALMGGLYIGFCFSSGAGAIEAYIERVSRssGFEYGKARMFGCLGWGLCASTAGML 166
Cdd:cd17325 271 GLLLSAVALLLLPLATSF-WLLLLLLALLGLGLGLVFPATLALLADIVPPEGR--GTAMGLFNTAFSLGMVLGPLLGGFL 347
|
170 180
....*....|....*....|....*...
gi 495055146 167 F-NVNPAIVFWMGSSAALVLMGLLLFAR 193
Cdd:cd17325 348 YdAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
32-195 |
1.79e-08 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 56.08 E-value: 1.79e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 32 FPFLPIWLSDVIGLNKTDTGIVFSCMSLFAIAFQPVLGVISDKLGLKKHLLWIITTLLVLFAPFFLWVFGPLLKVNIWLG 111
Cdd:cd17329 19 WPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLT 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 112 ALMGGLYIgfcfssgaGAIEAYIERVSRSSGFEYGKA--RMFGCLGWGLCASTAGMLFNVNPAIVFWMGSSAALVLMGLL 189
Cdd:cd17329 99 GFGGGLFE--------PASEAMIADVTTPENRTRAFSllYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVL 170
|
....*.
gi 495055146 190 LFARPR 195
Cdd:cd17329 171 LFLLPE 176
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
21-329 |
8.72e-08 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 53.79 E-value: 8.72e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 21 FFFYFFIMATCFPFLPIWLSDvIGLNKTDTGIVFSCMSLFAIAFQPVLGVISDKLGLKKhllWIITTLLVLFAPFFLWVF 100
Cdd:pfam12832 8 YFFYFAALGCLLPYWGLYLRS-IGLNPSEIGLITAILPLTRILAPPIWGWLADRTGKRK---AVVRLASILAAVLFLSVL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 101 GPLLKVNIWLGALMGGLYIGFCFSSGAGAIEAYIERVSRSSGfEYGKARMFGCLGWGLCASTAGMLFNVNPaivFWMGSS 180
Cdd:pfam12832 84 FIPISLTFWWLALLVVLFSFFWNAILPQFEVATLQHLGEKRK-DYGRQRLWGSVGFALSVFGLGALFDHYS---VGLLPS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 181 AALVLMGLLLFArprANQTAQVMNALGANQPQVTAKMALGLFRLPKLWMFILyvvgVACVYDVFDQQFATFFKSFFPTPQ 260
Cdd:pfam12832 160 VLFYLFAALMLL---SLLLPLAPPEMEYESKGGSKAVFWNLLKQPEVIIFFL----AAFLLGFSHGPFYTFLFLYLENLG 232
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 261 AGTQAFGFATTAGELCNAIIMFCSPWIINRIGAKNTLLIAGTIMATRIIG-SAFATNVYEIVALKMLHAL 329
Cdd:pfam12832 233 ASNTLLGALWALGVVAEIPLFFYAHRLLRRFGHRNLLIIALLLTALRWLLyAFFVENPWLVLPIQFLHAI 302
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
32-323 |
1.14e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 53.19 E-value: 1.14e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 32 FPFLPIWLSDVIGLNKTDTGIVFSCMSLFAIAFQPVLGVISDKLGLKKhllWIITTLLVLFAPFFLWVFGPLLKVNIWLG 111
Cdd:pfam07690 16 GPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRR---VLLIGLLLFALGLLLLLFASSLWLLLVLR 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 112 ALMGGLYiGFCFSSGAGAIEAYIERVSRSSGFeyGKARMFGCLGWGLCASTAGMLF-NVNPAIVFWMGSSAALVLMGLLL 190
Cdd:pfam07690 93 VLQGLGA-GALFPAALALIADWFPPEERGRAL--GLVSAGFGLGAALGPLLGGLLAsLFGWRAAFLILAILSLLAAVLLL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 191 FARPRANQTAQvmnaLGANQPQVTAKMALGLFRLPKLWMFILYVVGVACVYDVFDQQFATFFKSFFPTPQAGTQAFGFAT 270
Cdd:pfam07690 170 LPRPPPESKRP----KPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGG 245
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 495055146 271 TAGelcnAIIMFCSPWIINRIGAKNTLLIAGTIMATRIIGSAFATNVYEIVAL 323
Cdd:pfam07690 246 LLG----AIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWL 294
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
34-384 |
1.20e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 53.75 E-value: 1.20e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 34 FLPIWLSDVIGLNKTDTGIVFSCMSLFAIAFQPVLGVISD----KLGLKKHLLWIITTLLVLFAPFFLWVFGPLLKVNIW 109
Cdd:COG2211 32 YLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDrtrtRWGRRRPWILIGAIPLALSFVLLFTAPDLSPTGKLI 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 110 LGALMGGLYiGFCFSSGAGAIEAYIERVS-----RSSGFEYgkARMFGCLGWGLCASTAGMLFNV----NPAIVFWMGSS 180
Cdd:COG2211 112 YALVTYLLL-GLAYTLVNIPYSALGAELTpdyeeRTRLSSW--RFAFAGLGGLLASVLPPPLVAAfggdAALGYRLTALI 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 181 AALVLMGLLLFARPRANQTAQVmnalgANQPQVTAKMALGLFRLPKLWMFILYVVGVACVYDVFDQQFATFFKSFFptpQ 260
Cdd:COG2211 189 FAVLGLLAFLLTFFGTKERPVP-----EEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVL---G 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 261 AGTQAFGFATTAGELCNAIIMFCSPWIINRIGAKNTLLIAGTIMATRIIGSAFA--TNVYEIVALKMLHALEVPFLLVGA 338
Cdd:COG2211 261 LSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLP 340
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 495055146 339 FKYITGVFDTRLSAT------IYLIGFQFAKQMAAIFLSAFAGTMYDRIGFQ 384
Cdd:COG2211 341 WAMLADVVDYDEWKTgrrregLYFGIFTFAIKLGQALAGALAGLLLALFGYV 392
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
33-354 |
2.63e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 52.28 E-value: 2.63e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 33 PFLPiWLSDVIGLNKTDTGIVFSCMSLFAIAFQPVLGVISDKLGLKKHLLW-----IITTLLVLFAPFFLWVFgpllkvn 107
Cdd:COG2814 31 PALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLglllfALGSLLCALAPSLWLLL------- 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 108 iwLGALMGGLYIGFCFSSGAGAIEAYIERVSRSSGFeyGKARMFGCLGWGLCASTAGMLFN-VNPAIVFWMGSSAALVLM 186
Cdd:COG2814 103 --AARFLQGLGAGALFPAALALIADLVPPERRGRAL--GLLGAGLGLGPALGPLLGGLLADlFGWRWVFLVNAVLALLAL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 187 GLLLFARPRANQTAqvmnalganqPQVTAKMALGLFRLPKLWMFILYVVGVACVYDVFDQQFATFFKSFFptpQAGTQAF 266
Cdd:COG2814 179 LLLLRLLPESRPAA----------RARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL---GLSASAA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 267 GFATTAGELCNAIIMFCSPWIINRIGAKNTLLIAGTIMATRIIGSAFATNVYEIVALKMLHALEVPFLLVGAFKYITGVF 346
Cdd:COG2814 246 GLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELA 325
|
....*...
gi 495055146 347 DTRLSATI 354
Cdd:COG2814 326 PPEARGRA 333
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
27-403 |
1.10e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 47.18 E-value: 1.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 27 IMATC--FPFLPIWLSDVIGLNKTDTGIVFSCMSLFAIAFQPVLGVISDKLGLKKHLLW-IITTLLVLFAPFFLWVFGPL 103
Cdd:cd17473 12 VMAGAaiAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAgLLLYGIGGVAGLFLDSLYAL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 104 LKVNIWLGalmggLYIGFCFSSGAGAIEAYIERVSRSSGFeyGKARMFGCLGWGLCASTAGMLFNVNPAIVFWMGSSAAL 183
Cdd:cd17473 92 LASRALLG-----IGVAGIMTLATALIGDYFEGEERAKML--GLQSAAMSLGGVVFLLLGGALAEIGWRAPFLVYLLALP 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 184 VLMGLLLFARPRANQtaqvmnalgANQPQVTAKMALGLFRLPKLWMFILYVVGVACVYDVFDQQFATFFKSFFPTPQAGT 263
Cdd:cd17473 165 VLILVLLFLPEPARK---------SKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 264 qafGFATTAGELCNAIIMFCSPWIINRIGAKNTLLIAGTIMATRIIGSAFATNVYEIVALKMLHALEVPFLLVGAFKYIT 343
Cdd:cd17473 236 ---GLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAM 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 495055146 344 GVFDTRLS--ATIYLIGFQFAKQMAAIFLSAFAGTMYDriGFQDTYLILGSFVLAITVVSAF 403
Cdd:cd17473 313 SLVPPELRgrAMGIVTSAFFLGQFLSPLVLGPLVNLTG--GLSGAFLILGVLALVLAIVLLL 372
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
39-410 |
3.10e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 45.63 E-value: 3.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 39 LSDVIGLNKTDTGIVFSCMSLFAIAFQPVLGVISDKLGLKKhLLWIITTLLVLFAPFFLWVFGPLLkvnIWLGALMGGLY 118
Cdd:COG2271 36 LQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRR-VLAIGLLLWGLATLLFGFATSFWQ---LLLLRFLLGLG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 119 IGFCFSSGAGAIEAYIERVSRssgfeygkARMFGClgWGLCASTAGMLFN-VNPAIVFWMGSSAALVLMGLLLFarpran 197
Cdd:COG2271 112 EAGFFPAALKLIAEWFPPKER--------GRALGI--FNAGGPLGGALAPpLLGWLLAAFGWRAAFLILGLPGL------ 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 198 qtaqvmnalganqpqvtakmalgLFRLPKLWMFILYVVGVACVYDVFDQQFATFFKSFFptpQAGTQAFGFATTAGELCN 277
Cdd:COG2271 176 -----------------------LLALLRFWLLALAYFLVYFALYGFLTWLPTYLVEVR---GLSLAQAGLLLSLPFLAG 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 278 AIIMFCSPWIINRIGA--KNTLLIAGTIMATRIIGSAFATNVYEIVALKMLHALEVPFLLVGAFKYITGVFDTRLSATIY 355
Cdd:COG2271 230 IVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTAS 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 495055146 356 LIGFqFAKQMAAIFLSAFAGTMYDRIGFQDTYLILGSFVLAITVVSAFTLTNTRQ 410
Cdd:COG2271 310 GLVN-TFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
39-411 |
1.04e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 44.07 E-value: 1.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 39 LSDVIGLNKTDTGIVFSCMSLFAIAFQPVLGVISDKLGLKKHllwIITTLLVLFAPFFLWVFGPllkvnIWLGALMGGLY 118
Cdd:COG0738 34 LKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRG---LLLGLLLMALGLLLFALAP-----SYPLLLLALFL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 119 IGFCFSSGAGAIEAYIERVSRssgfEYGKARM-----FGCLGWGLCASTAGMLF--NVNPAIVFWMGSSAALVLMGLLLF 191
Cdd:COG0738 106 LGLGLGLLDVAANPYVAALGP----ETAASRLnllhaFFSLGALLGPLLGGLLIllGLSLSWHLPYLILAVLLLLLALLF 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 192 ARPRANQTAQVmnalgANQPQVTAKMALGLFRLPKLWMFILYVVGVACVYDVFDQQFATFFKSFFptpQAGTQAFGFATT 271
Cdd:COG0738 182 LRSKLPEIEEE-----EEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVL---GLSEATAALGLS 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 272 AGELCNAIIMFCSPWIINRIGAKNTLLIAGTIMATRIIGSAFATNVYEIVALkmlhalevpFLLVGAFkyITGVFDTRLS 351
Cdd:COG0738 254 LFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIG---------LALVGLG--LSLMFPTIFS 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495055146 352 ATIYLIGFQFAKQMAAIFLSAFAGTM---------YDRIGFQDTYLILGSFVLAITVVSAFTLTNTRQA 411
Cdd:COG0738 323 LALDGLGKRTAAAVSAVLIMGIVGGAigppligflADAFGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
48-403 |
1.38e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 43.76 E-value: 1.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 48 TDTGIVFSCMSLFAIAFQPVLGVISDKLGLKKHLLWIITTLLVLFAPFFLWVFGPLLkvNIWLGALMGGLyIGFCFSSGA 127
Cdd:cd06173 34 LLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSL--SLWLLLVLAFL-LGIASAFFG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 128 GAIEAYI------ERVSRSSGFEYGKARMFGCLGWGLcastAGMLFNVNPAIVFWMGSSAALVLMGLLLFARPRANQTAQ 201
Cdd:cd06173 111 PARQALLpelvpkEQLVRANALNSLATQLARIIGPAL----GGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAP 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 202 vmNALGANQPQVTAKMALGLFRLPKLWMFILYVVGVACVYDVFDQQFATFFKSffpTPQAGTQAFGFATTAGELCNAIIM 281
Cdd:cd06173 187 --GESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKE---VLGGGAAGYGLLLAAFGVGALLGA 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 282 FCSPWIINRIGAKNTLLIAGTIMATRIIGSAFATNVYEIVALKMLHALEVPFLLVGAFKYITGVFDTRLSATIYLIGFQF 361
Cdd:cd06173 262 LLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNAL 341
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 495055146 362 AkQMAAIFLSAFAGTMYDRIGFQDTYLILGSFVLAITVVSAF 403
Cdd:cd06173 342 N-SGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
34-196 |
2.95e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 42.55 E-value: 2.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 34 FLPIWLSDVIGLNKTDTGIVFSCMSLFAIAFQPVLGVISDKLGLKKHLLWIITTLLVLFAPFFLWVFGPLLKVNIWLGAl 113
Cdd:COG2271 202 WLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFL- 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 114 mgglyIGFCFSSGAGAIEAYIERV--SRSSGFEYGKARMFGCLGWGLCASTAGMLF-NVNPAIVFWMGSSAALVLMGLLL 190
Cdd:COG2271 281 -----AGFGLGGAFGLLWALAAELfpKKARGTASGLVNTFGFLGGALGPLLVGYLLdATGYQAAFLLLAALALLAALLAL 355
|
....*.
gi 495055146 191 FARPRA 196
Cdd:COG2271 356 LLLRET 361
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
32-97 |
4.82e-04 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 41.96 E-value: 4.82e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 495055146 32 FPFLPIWLSDVIGLNKTDTGIVFSCMSLFAIAFQPVLGVISDKLGLKKHLLWIITTLLVLFAPFFL 97
Cdd:cd17366 213 LSYMPSYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAGLAGLLVLAVPAFL 278
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
34-118 |
6.50e-04 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 41.72 E-value: 6.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 34 FLPIWLSDVIGLNKTDTGIVFSCMSLFAIAFQPVLGVISDKLGLKKHLLWI------ITTLLVLFAPFFlwvFGPllkvN 107
Cdd:cd17337 230 FMPLYFTDTGGFSTSQWLQIWGIIFLVNIFFNLIFGILGDKIGWRRTVRWFggvgcaISTLLFYYVPQL---FGH----N 302
|
90
....*....|.
gi 495055146 108 IWLGALMGGLY 118
Cdd:cd17337 303 YWAALIAAILF 313
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
261-411 |
1.76e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 40.34 E-value: 1.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 261 AGTQAFGFATTAGELCNAIIMFCSPWIINRIGAKNTLLIAGTIMATRIIGSAFATNVYEIVALKMLHALEVPFLLVGAFK 340
Cdd:COG2814 42 ASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALA 121
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 495055146 341 YITGVFDTRLSATIylIGFQFAKQMAAIFLSAF-AGTMYDRIGFQDTYLILGSFVLAITVVSAFTLTNTRQA 411
Cdd:COG2814 122 LIADLVPPERRGRA--LGLLGAGLGLGPALGPLlGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPA 191
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
9-121 |
2.47e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 39.89 E-value: 2.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 9 KHNPNFWIFGLFFFFYFFIMATCFPFLPIWLSDVIGLNKTDTGIVFSCMSLFAIAFQPVLGVISDKLGlkKHLLWIITTL 88
Cdd:COG2211 225 LKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFG--KKKAFIIGLL 302
|
90 100 110
....*....|....*....|....*....|...
gi 495055146 89 LVLFAPFFLWVFGPLLKVNIWLGALMGGLYIGF 121
Cdd:COG2211 303 LAALGLLLLFFLGPGNLWLLLVLAALAGIGLGA 335
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
10-121 |
2.90e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 39.57 E-value: 2.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 10 HNPNFWIFGLFFFFYFFIMATCFPFLPIWLSDVIGLNKTDTGIVFSCMSLFAIAFQPVLGVISDKLGLKKHLLWiitTLL 89
Cdd:COG2814 205 RRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLI---GLL 281
|
90 100 110
....*....|....*....|....*....|..
gi 495055146 90 VLFAPFFLWVFGPLLKVNIWLGALMGGLYIGF 121
Cdd:COG2814 282 LLALGLLLLALAGSLWLLLLALFLLGFGFGLL 313
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
34-125 |
5.22e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 38.98 E-value: 5.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 34 FLPIWLSDVIGLNKTDT-----GIVFSCMSLFAIAFQPVLGVISDKLGLKKHLLWIITTLLVLFApFFLWVFGPLlkvNI 108
Cdd:COG2270 33 VFPPYFTSVAALGDPAAatalwGYALAIAGLLVALLAPVLGAIADRSGRKKPFLAFFTLLGVLAT-AALFFVAPG---GL 108
|
90
....*....|....*...
gi 495055146 109 WLGALMGGL-YIGFCFSS 125
Cdd:COG2270 109 WLGLLLFVLaNIGFEGSL 126
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
290-419 |
9.96e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 38.01 E-value: 9.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495055146 290 RIGAKNTLLIAGTIMATRIIGSAFATNVYEIVALKMLhalevpfllvgafkyiTGVFDTRLSATIYLIGFQFAKQ----- 364
Cdd:cd17391 62 RYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLL----------------QGVFSGYVPNATALIASQTPKEksgwa 125
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 495055146 365 MAAIFLSAFAGTMY---------DRIGFQDTYLILGSFVLAITVVSAFTLTNTRQAVVSEETVK 419
Cdd:cd17391 126 LGTLSTGVVAGTLIgpllggflaDLFGIRNVFFITGGLLFLAFLLTLFFVKEDFKPVEKKKMVS 189
|
|
| |
