|
Name |
Accession |
Description |
Interval |
E-value |
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
1-457 |
0e+00 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 804.15 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 1 MIGSLTARIFAIFWLTLALVLMLVLMLPKLDSRQMTELLESEQRQGTMIEQHVEAELAGDPPNDLMWWRRLFRAIDKWAP 80
Cdd:PRK09470 5 MINSLTARIFAIFWLTLALVLMLVLMLPKLDSRQMTELLDSEQRQGLMIEQHIEAELANDPPNDLMWWRRLFRAIDKWAP 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 81 PGQRLLLVTSEGRVIGAERNEMQIIRNFIGQSDNSDHPQKKKYGRVELVGPFSVRDGEDNYQLYLIRPASNSQSDFINLL 160
Cdd:PRK09470 85 PGQRLLLVTSEGRIIGAERSEMQAVRNFIGQSDNADHPQKKKYGRVEIVGPFSVRDGEDNYQLYLIRPANSPQSDFINLL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 161 FDRPLLLLIVTMLVSSPLLLWLAWSLARPARKLKNAADEVAQGNLRQHPELEAGPQEFIAAGASFNQMVTALERMMTTQQ 240
Cdd:PRK09470 165 FDRPLLLLLVTMLVSTPLLLWLAWSLAKPARKLKNAADEVAQGNLRQHPELETGPQEFRQAGASFNQMVTALERMMTSQQ 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 241 RLLSDISHELRTPLTRLQLGTALLRRRSGESKELERIETEAHRLDSMINDLLVMSRNQQKNALVSETMKANQIWGEVLDN 320
Cdd:PRK09470 245 RLLSDISHELRTPLTRLQLATALLRRRQGESKELERIETEAQRLDSMINDLLVLSRNQQKNHLERETFKANSLWSEVLED 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 321 AAFEAEQMGKSFEVTYPPGPWLLYGNPNALESALENIVRNALRYSHSKISVSFAVDKEGITINVDDDGPGVSQADREQIF 400
Cdd:PRK09470 325 AKFEAEQMGKSLTVSAPPGPWPINGNPNALASALENIVRNALRYSHTKIEVAFSVDKDGLTITVDDDGPGVPEEEREQIF 404
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 495054612 401 RPFYRTDEARDRESGGTGLGLAIVETAVQQHRGWVKADDSPLGGLRLTLWLPLYHRS 457
Cdd:PRK09470 405 RPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLPLYKRS 461
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
138-455 |
1.56e-66 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 218.27 E-value: 1.56e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 138 EDNYQLYLIRPASNSQSDFINLLFDRPLLLLIVTMLVSSPLLLWLAWSLARPARKLKNAADEVAQGNLRQHPELEAGPQE 217
Cdd:COG5002 64 LLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLL 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 218 FIAAGASFNQMVTALERMMTTQQRLLSDISHELRTPLTRLQLGTALLRRRSGESKE-----LERIETEAHRLDSMINDLL 292
Cdd:COG5002 144 GLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEerreyLEIILEEAERLSRLVNDLL 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 293 VMSR-NQQKNALVSETMKANQIWGEVLDNAAFEAEQMGKSFEVTYPPGPWLLYGNPNALESALENIVRNALRYSH--SKI 369
Cdd:COG5002 224 DLSRlESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPegGTI 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 370 SVSFAVDKEGITINVDDDGPGVSQADREQIFRPFYRTDEARDRESGGTGLGLAIVETAVQQHRGWVKADDSPLGGLRLTL 449
Cdd:COG5002 304 TVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTI 383
|
....*.
gi 495054612 450 WLPLYH 455
Cdd:COG5002 384 TLPLAR 389
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
142-453 |
2.86e-61 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 202.45 E-value: 2.86e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 142 QLYLIRPASNSQSDFINLLFDRPLLLLIVTMLVSSPLLLWLAWSLARPARKLKNAADEVAQGNLRQHPELEAGPQEFIAA 221
Cdd:COG0642 13 LLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 222 GASFNQMVTALERMMTTQQRLLSDISHELRTPLTRLQLGTALLRRRSGE--SKELERIETEAHRLDSMINDLLVMSR-NQ 298
Cdd:COG0642 93 LLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEeqREYLETILRSADRLLRLINDLLDLSRlEA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 299 QKNALVSETMKANQIWGEVLDNAAFEAEQMGKSFEVTYPPGPWLLYGNPNALESALENIVRNALRYSH--SKISVSFAVD 376
Cdd:COG0642 173 GKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPegGTVTVSVRRE 252
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 495054612 377 KEGITINVDDDGPGVSQADREQIFRPFYRTDEArdRESGGTGLGLAIVETAVQQHRGWVKADDSPLGGLRLTLWLPL 453
Cdd:COG0642 253 GDRVRISVEDTGPGIPPEDLERIFEPFFRTDPS--RRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPL 327
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
226-453 |
1.72e-59 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 194.74 E-value: 1.72e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 226 NQMVTALERMMTTQQRLLSDISHELRTPLTRLQLGTALLRRRSGESKE-----LERIETEAHRLDSMINDLLVMSRNQ-Q 299
Cdd:COG2205 3 EEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEerrelLEIIRESAERLLRLIEDLLDLSRLEsG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 300 KNALVSETMKANQIWGEVLDNAAFEAEQMGKSFEVTYPPGPWLLYGNPNALESALENIVRNALRYS--HSKISVSFAVDK 377
Cdd:COG2205 83 KLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSppGGTITISARREG 162
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 495054612 378 EGITINVDDDGPGVSQADREQIFRPFYRTDeaRDRESGGTGLGLAIVETAVQQHRGWVKADDSPLGGLRLTLWLPL 453
Cdd:COG2205 163 DGVRISVSDNGPGIPEEELERIFERFYRGD--NSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPL 236
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-453 |
8.60e-57 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 182.91 E-value: 8.60e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 350 LESALENIVRNALRYSHSKISVSFAVDKEGITINVDDDGPGVSQADREQIFRPFYRTDEARDRESGGTGLGLAIVETAVQ 429
Cdd:cd16949 1 LARALENVLRNALRYSPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERAIE 80
|
90 100
....*....|....*....|....
gi 495054612 430 QHRGWVKADDSPLGGLRLTLWLPL 453
Cdd:cd16949 81 QHGGKIKASNRKPGGLRVRIWLPA 104
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
188-455 |
3.92e-52 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 181.34 E-value: 3.92e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 188 RPARKLKNAADEVAQGNLRQHPELEAGpQEFIAAGASFNQMVTALERMMTTQQRLLSDISHELRTPLTRLQLGTALLRRR 267
Cdd:PRK10604 162 QDMLKLEAAAQRLGDGHLAERIHFDEG-SSLERLGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEMSDNL 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 268 S-GESKELERietEAHRLDSMINDLLVMSR-NQQKNALVSETMKANQIWGEVLDNaaFEAEQMGKSFEVTYPPGPWLLYG 345
Cdd:PRK10604 241 SaAESQALNR---DIGQLEALIEELLTYARlDRPQNELHLSEPDLPAWLSTHLAD--IQAVTPEKTVRLDTPHQGDYGAL 315
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 346 NPNALESALENIVRNALRYSHSKISVSFAVDKEGITINVDDDGPGVSQADREQIFRPFYRTDEARDRESGGTGLGLAIVE 425
Cdd:PRK10604 316 DMRLMERVLDNLLNNALRYAHSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVH 395
|
250 260 270
....*....|....*....|....*....|
gi 495054612 426 TAVQQHRGWVKADDSPLGGLRLTLWLPLYH 455
Cdd:PRK10604 396 SIALAMGGSVNCDESELGGARFSFSWPVWH 425
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
188-453 |
3.65e-43 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 157.38 E-value: 3.65e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 188 RPARKLKNAADEVAQGNlrqHPE--LEAGPQEFIAAGASFNQM---VTALErmmttQQR--LLSDISHELRTPLTRLQLG 260
Cdd:PRK09467 179 RPLVALEHAALQVGKGE---IPPplREYGASEVRSVTRAFNQMaagIKQLE-----DDRtlLMAGVSHDLRTPLTRIRLA 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 261 TALLrrrSGESKEL-ERIETEAHRLDSMINDLLVMSRNQQKnaLVSETMKANQIWGEVldnAAFEAEQmGKSFEVTYPPG 339
Cdd:PRK09467 251 TEMM---SEEDGYLaESINKDIEECNAIIEQFIDYLRTGQE--MPMEMADLNALLGEV---IAAESGY-EREIETALQPG 321
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 340 PWLLYGNPNALESALENIVRNALRYSHSKISVSFAVDKEGITINVDDDGPGVSQADREQIFRPFYRTDEARDreSGGTGL 419
Cdd:PRK09467 322 PIEVPMNPIAIKRALANLVVNAARYGNGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARG--SSGTGL 399
|
250 260 270
....*....|....*....|....*....|....
gi 495054612 420 GLAIVETAVQQHRGWVKADDSPLGGLRLTLWLPL 453
Cdd:PRK09467 400 GLAIVKRIVDQHNGKVELGNSEEGGLSARAWLPL 433
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
140-449 |
3.55e-37 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 142.47 E-value: 3.55e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 140 NYQLYLIRPASNSQS--DFINLLFDRPLLLLIV-----TMLVSsplllwlaWSLARPARKLKNAADEVAQGNLRQHPElE 212
Cdd:NF040691 167 NYELYLLFPLEDEQStlALVRGTLLLGGLALVVllgliAWLVT--------RQVVAPVRSAARTAERFAAGDLSERMP-V 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 213 AGPQEFIAAGASFNQMVTALER-------MMTTQQRLLSDISHELRTPLTRLQLGTALLRRRSGE-------SKELERIE 278
Cdd:NF040691 238 KGEDDLARLARSFNQMADSLQRqirqleeLSRLQQRFVSDVSHELRTPLTTIRMAADVIHDSRDDfdpatarSAELLHTE 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 279 TEahRLDSMINDLLVMSR-NQQKNALVSETMKANQIWGEVLDNAAFEAEQMGKSFEVTYPPGPWLLYGNPNALESALENI 357
Cdd:NF040691 318 LD--RFESLLSDLLEISRfDAGAAELDVEPVDLRPLVRRVVDALRQLAERAGVELRVDAPGTPVVAEVDPRRVERVLRNL 395
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 358 VRNALRYS-HSKISVSFAVDKEGITINVDDDGPGVSQADREQIFRPFYRTDEARDRESGGTGLGLAIVETAVQQHRGWVK 436
Cdd:NF040691 396 VVNAIEHGeGKPVVVTVAQDDTAVAVTVRDHGVGLKPGEVALVFDRFWRADPARARTTGGTGLGLAIALEDARLHGGWLE 475
|
330
....*....|....*
gi 495054612 437 ADDSPLGG--LRLTL 449
Cdd:NF040691 476 AWGRPGQGsqFRLTL 490
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-453 |
2.60e-35 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 126.78 E-value: 2.60e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 350 LESALENIVRNALRYSHSKISVSFAVDKEGITINVDDDGPGVSQADREQIFRPFYRTDEARDRESGGTGLGLAIVETAVQ 429
Cdd:cd16939 1 MARALDNLLRNALRYAHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVAL 80
|
90 100
....*....|....*....|....
gi 495054612 430 QHRGWVKADDSPLGGLRLTLWLPL 453
Cdd:cd16939 81 WHGGHVECDDSELGGACFRLTWPR 104
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
189-452 |
9.86e-35 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 134.57 E-value: 9.86e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 189 PARKLKNAADEVAQGNLrQHPELEAGPQEFIAAGASFNQMVTALERMMTTQQRLLSDISHELRTPLTRLQLGTALLRR-- 266
Cdd:NF012163 191 PVKRLVEATHRLAAGDY-TTRVTPTSNDELGKLAQDFNQLASTLEKNEQMRRDFMADISHELRTPLAVLRAELEAIQDgi 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 267 RSGESKELERIETEAHRLDSMINDLLVMSRNQQkNALVSETMKANQIwgEVLDNA--AFEA--EQMGKSFEVTYPPGPwL 342
Cdd:NF012163 270 RKFTPESLDSLQAEVGTLTKLVDDLHDLSMSDE-GALAYQKASVDLV--PLLEVEggAFRErfASAGLELEVSLPDSS-L 345
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 343 LYGNPNALESALENIVRNALRYSHS--KISVSFAVDKEGITINVDDDGPGVSQADREQIFRPFYRTDEARDRESGGTGLG 420
Cdd:NF012163 346 VFGDRDRLMQLFNNLLENSLRYTDSggSLHISASQRPKEVTLTVADSAPGVSDEQLARLFERFYRVEVSRNRASGGSGLG 425
|
250 260 270
....*....|....*....|....*....|..
gi 495054612 421 LAIVETAVQQHRGWVKADDSPLGGLRLTLWLP 452
Cdd:NF012163 426 LAISLNIVQAHGGTLHAAHSPLGGLRIVVTLP 457
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
229-453 |
1.67e-34 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 133.55 E-value: 1.67e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 229 VTALERM--MTTQQRLLSDISHELRTPLTRLQLGTALLRRRSGESKE---------LERIETEAHRLDSMINDLLVMSRN 297
Cdd:COG5000 189 ITELLRAerLAAWGELARRIAHEIKNPLTPIQLSAERLRRKLADKLEedredleraLDTIIRQVDRLKRIVDEFLDFARL 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 298 QQknaLVSETMKANQIWGEVLDNAAFEAEQMGKSFEVTYPPGPWLLYGNPNALESALENIVRNALR--YSHSKISVSFAV 375
Cdd:COG5000 269 PE---PQLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLPEVLADRDQLEQVLINLLKNAIEaiEEGGEIEVSTRR 345
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 495054612 376 DKEGITINVDDDGPGVSQADREQIFRPFYRTDEardresGGTGLGLAIVETAVQQHRGWVKADDSPLGGLRLTLWLPL 453
Cdd:COG5000 346 EDGRVRIEVSDNGPGIPEEVLERIFEPFFTTKP------KGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPL 417
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
227-456 |
2.02e-34 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 134.53 E-value: 2.02e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 227 QMVTALERMMTTQQRLLSDISHELRTPLTRLQLGTALLRRRSGES------KELERIETEAHRLDSMINDLLVMSRnQQK 300
Cdd:COG4251 270 ERTAELERSNEELEQFAYVASHDLREPLRKISGFSQLLEEDYGDKldeegrEYLERIRDAAERMQALIDDLLAYSR-VGR 348
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 301 NALVSETMKANQIWGEVLDNAAFEAEQmgKSFEVTYPPGPWLlYGNPNALESALENIVRNALRYSHS----KISVSFAVD 376
Cdd:COG4251 349 QELEFEPVDLNELLEEVLEDLEPRIEE--RGAEIEVGPLPTV-RGDPTLLRQVFQNLISNAIKYSRPgeppRIEIGAERE 425
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 377 KEGITINVDDDGPGVSQADREQIFRPFYRTDEARDREsgGTGLGLAIVETAVQQHRGWVKADDSPLGGLRLTLWLPLYHR 456
Cdd:COG4251 426 GGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRDEYE--GTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPKAPA 503
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
229-433 |
9.95e-34 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 129.25 E-value: 9.95e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 229 VTALERMMTTQQRLLSDISHELRTPLTRLQ-----LGTALLRRRSGESKELERIETEAHRLDSMINDLLVMSR-----NQ 298
Cdd:TIGR02966 104 VTRLRRLEQMRRDFVANVSHELRTPLTVLRgyletLADGPDEDPEEWNRALEIMLEQSQRMQSLVEDLLTLSRlesaaSP 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 299 QKNALVSetMkanqiwGEVLDNAAFEAEQM--GK----SFEVTypPGPWLLyGNPNALESALENIVRNALRYS--HSKIS 370
Cdd:TIGR02966 184 LEDEPVD--M------PALLDHLRDEAEALsqGKnhqiTFEID--GGVDVL-GDEDELRSAFSNLVSNAIKYTpeGGTIT 252
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 495054612 371 VSFAVDKEGITINVDDDGPGVSQADREQIFRPFYRTDEARDRESGGTGLGLAIVETAVQQHRG 433
Cdd:TIGR02966 253 VRWRRDGGGAEFSVTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRHHA 315
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
241-453 |
5.39e-33 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 127.99 E-value: 5.39e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 241 RLLSDISHELRTPLTRLQLGTALLRRRSGESKE-------LERIETEAHRLDSMINDLLVMSRNQQknaLVSETMKANQI 313
Cdd:COG4191 144 ELAAGIAHEINNPLAAILGNAELLRRRLEDEPDpeelreaLERILEGAERAAEIVRSLRAFSRRDE---EEREPVDLNEL 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 314 WGEVLDNAAFEAEQMGKSFEVTYPPGPWLLYGNPNALESALENIVRNAL----RYSHSKISVSFAVDKEGITINVDDDGP 389
Cdd:COG4191 221 IDEALELLRPRLKARGIEVELDLPPDLPPVLGDPGQLEQVLLNLLINAIdameEGEGGRITISTRREGDYVVISVRDNGP 300
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 495054612 390 GVSQADREQIFRPFYRTDEardrESGGTGLGLAIVETAVQQHRGWVKADDSPLGGLRLTLWLPL 453
Cdd:COG4191 301 GIPPEVLERIFEPFFTTKP----VGKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPL 360
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
225-455 |
5.55e-33 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 129.75 E-value: 5.55e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 225 FNQMVTALERMMTTQQRLLSDISHELRTPLT-------RLQLGtalLRRRSGESkeLERIETEAHRLDSMINDL--LVMS 295
Cdd:PRK10549 226 FNQLASTLEKNEQMRRDFMADISHELRTPLAvlrgeleAIQDG---VRKFTPES--VASLQAEVGTLTKLVDDLhqLSLS 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 296 rnqQKNALVSETMKANQIWGEVLDNAAFEAEQMGKSFEVTYP-PGPWLLYGNPNALESALENIVRNALRY--SHSKISVS 372
Cdd:PRK10549 301 ---DEGALAYRKTPVDLVPLLEVAGGAFRERFASRGLTLQLSlPDSATVFGDPDRLMQLFNNLLENSLRYtdSGGSLHIS 377
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 373 FAVDKEGITINVDDDGPGVSQADREQIFRPFYRTDEARDRESGGTGLGLAIVETAVQQHRGWVKADDSPLGGLRLTLWLP 452
Cdd:PRK10549 378 AEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELP 457
|
...
gi 495054612 453 LYH 455
Cdd:PRK10549 458 LER 460
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
232-457 |
1.55e-32 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 126.88 E-value: 1.55e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 232 LERMMTTQQRLLS------DISHELRTPLTRLQLGTALLRRRSGESKELE---RIETEAHRLDSMINDLLVMSRNQQkna 302
Cdd:COG3852 122 LERELRRAEKLAAvgelaaGLAHEIRNPLTGIRGAAQLLERELPDDELREytqLIIEEADRLNNLVDRLLSFSRPRP--- 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 303 LVSETMKANQIWGEVLDNAAFEAEQmGKSFEVTYPPGPWLLYGNPNALESALENIVRNAL-------------RYSHSkI 369
Cdd:COG3852 199 PEREPVNLHEVLERVLELLRAEAPK-NIRIVRDYDPSLPEVLGDPDQLIQVLLNLVRNAAeampeggtitirtRVERQ-V 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 370 SVSFAVDKEGITINVDDDGPGVSQADREQIFRPFYRTDEardresGGTGLGLAIVETAVQQHRGWVKADDSPLGGLRLTL 449
Cdd:COG3852 277 TLGGLRPRLYVRIEVIDNGPGIPEEILDRIFEPFFTTKE------KGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRI 350
|
....*...
gi 495054612 450 WLPLYHRS 457
Cdd:COG3852 351 YLPLEQAE 358
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
188-452 |
1.64e-32 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 128.66 E-value: 1.64e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 188 RPARKLKNAADEVAQGNLRQHPELEAGPQEFIAAGASFNQMVTALERMMTTQQRLLSDISHELRTPLTRL--QLGTALLR 265
Cdd:TIGR01386 190 EPLRRLSAVAARISPESLDQRLDPSRAPAELRELAQSFNAMLGRLEDAFQRLSQFSADLAHELRTPLTNLlgQTQVALSQ 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 266 RRSGESKE--LERIETEAHRLDSMINDLLVMSRNQQKN-ALVSETMKANQIWGEVLDNAAFEAEQMGKSFEVTyppGPWL 342
Cdd:TIGR01386 270 PRTGEEYRevLESNLEELERLSRMVSDMLFLARADNGQlALERVRLDLAAELAKVAEYFEPLAEERGVRIRVE---GEGL 346
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 343 LYGNPNALESALENIVRNALRYS--HSKISVSFAVDKEGITINVDDDGPGVSQADREQIFRPFYRTDEARDRESGGTGLG 420
Cdd:TIGR01386 347 VRGDPQMFRRAISNLLSNALRHTpdGGTITVRIERRSDEVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLG 426
|
250 260 270
....*....|....*....|....*....|..
gi 495054612 421 LAIVETAVQQHRGWVKAdDSPLGGLRLTLWLP 452
Cdd:TIGR01386 427 LAIVRSIMEAHGGRASA-ESPDGKTRFILRFP 457
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
345-453 |
2.52e-30 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 113.51 E-value: 2.52e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 345 GNPNALESALENIVRNALRYSHS--KISVSFAVDKEGITINVDDDGPGVSQADREQIFRPFYRTDEaRDRESGGTGLGLA 422
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEggRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|.
gi 495054612 423 IVETAVQQHRGWVKADDSPLGGLRLTLWLPL 453
Cdd:smart00387 80 IVKKLVELHGGEISVESEPGGGTTFTITLPL 110
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
350-451 |
2.16e-29 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 110.39 E-value: 2.16e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 350 LESALENIVRNALRYS--HSKISVSFAVDKEGITINVDDDGPGVSQADREQIFRPFYRTDEArdRESGGTGLGLAIVETA 427
Cdd:cd00075 1 LEQVLSNLLDNALKYSppGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKS--REGGGTGLGLAIVRRI 78
|
90 100
....*....|....*....|....
gi 495054612 428 VQQHRGWVKADDSPLGGLRLTLWL 451
Cdd:cd00075 79 VEAHGGRITVESEPGGGTTFTVTL 102
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
346-452 |
1.66e-26 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 102.93 E-value: 1.66e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 346 NPNALESALENIVRNALRYSHS--KISVSFAVDKEGITINVDDDGPGVSQADREQIFRPFYRTDEARDRESGGTGLGLAI 423
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTggKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 495054612 424 VETAVQQHRGWVKADDSPLGGLRLTLWLP 452
Cdd:cd16946 81 CHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
188-452 |
2.52e-26 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 111.02 E-value: 2.52e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 188 RPARKLKNAADEVAQGNLRQHPELEAGPQEFIAAGASFNQMVTALERMMTTQQRLLSDISHELRTPLTRL--QLGTALLR 265
Cdd:PRK09835 211 APIRSVSRQIQNITSKDLDVRLDPQTVPIELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLitQTEIALSQ 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 266 RRSgeSKELERI----ETEAHRLDSMINDLLVMSR--NQQ----KNA--LVSETMKanqiwgeVLDnaAFEAEQMGKSFE 333
Cdd:PRK09835 291 SRS--QKELEDVlysnLEELTRMAKMVSDMLFLAQadNNQlipeKKMldLADEVGK-------VFD--FFEAWAEERGVE 359
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 334 VTYPPGPWLLYGNPNALESALENIVRNALRYSHS--KISVSFAVDKEGITINVDDDGPGVSQADREQIFRPFYRTDEARD 411
Cdd:PRK09835 360 LRFVGDPCQVAGDPLMLRRAISNLLSNALRYTPAgeAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQ 439
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 495054612 412 RESGGTGLGLAIVETAVQQHRG--WVKADdspLGGLRLTLWLP 452
Cdd:PRK09835 440 RKGEGSGIGLAIVKSIVVAHKGtvAVTSD---ARGTRFVISLP 479
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
188-453 |
5.64e-26 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 109.93 E-value: 5.64e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 188 RPARKLKNAADEVAQGNLRQHPELeaGPQEFIAAGASFNQMVTALE---------RMMTtqqrllsdisHELRTPLTRLq 258
Cdd:PRK11100 208 RSIRRLTRYADAVTEGKPVPLPKL--GSSELRELAQALESMRVKLEgkayveqyvQTLT----------HELKSPLAAI- 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 259 LGTALLRRRSGESKELER----IETEAHRLDSMINDLLVMSRNQQKNAL-VSETMKANQIWGEVLDNAAFEAEQMGKSFE 333
Cdd:PRK11100 275 RGAAELLQEDPPPEDRARftgnILTQSARLQQLIDRLLELARLEQRQELeVLEPVALAALLEELVEAREAQAAAKGITLR 354
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 334 VTyPPGPWLLyGNPNALESALENIVRNALRYSH--SKISVSFAVDKEGITINVDDDGPGVSQADREQIFRPFY---RTDE 408
Cdd:PRK11100 355 LR-PDDARVL-GDPFLLRQALGNLLDNAIDFSPegGTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERFYslpRPAN 432
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 495054612 409 ARDresgGTGLGLAIVETAVQQHRGWVKADDSPLGGLRLTLWLPL 453
Cdd:PRK11100 433 GRK----STGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPR 473
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
345-453 |
1.01e-24 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 98.21 E-value: 1.01e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 345 GNPNALESALENIVRNALRYSHSKISVSFAVDKEG-ITINVDDDGPGVSQADREQIFRPFYRTDearDRESGGTGLGLAI 423
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEGGeLTLTVEDNGIGIPPEDLPRIFEPFSTAD---KRGGGGTGLGLSI 77
|
90 100 110
....*....|....*....|....*....|
gi 495054612 424 VETAVQQHRGWVKADDSPLGGLRLTLWLPL 453
Cdd:pfam02518 78 VRKLVELLGGTITVESEPGGGTTVTLTLPL 107
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
216-452 |
9.98e-24 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 101.97 E-value: 9.98e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 216 QEFIAAGASFNQMVTaleRMMTT--QQRLL-SDISHELRTPLTRLQLGTALLRRRSG-ESKELerIEteahRLDSM---I 288
Cdd:PRK10755 114 LEIEAVTSALNQLVS---RLTSTldQERLFtADVAHELRTPLAGIRLHLELLEKQHHiDVAPL--IA----RLDQMmhtV 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 289 NDLLVMSR--------NQQKNALVSETMKANQiwgevlDNAAFEAEQMGKSFEVTYPPGPWLLYGNPNALESALENIVRN 360
Cdd:PRK10755 185 EQLLQLARagqsfssgHYQTVKLLEDVILPSQ------DELSEMLEQRQQTLLLPESAADITVQGDATLLRLLLRNLVEN 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 361 ALRYS--HSKISVSFAVDKEGITINVDDDGPGVSQADREQIFRPFYRTdearDRESGGTGLGLAIVETAVQQHRGWVKAD 438
Cdd:PRK10755 259 AHRYSpeGSTITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRM----DSRYGGIGLGLSIVSRITQLHHGQFFLQ 334
|
250
....*....|....*
gi 495054612 439 D-SPLGGLRLTLWLP 452
Cdd:PRK10755 335 NrQERSGTRAWVWLP 349
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-452 |
1.79e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 94.44 E-value: 1.79e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 350 LESALENIVRNALRYSHSKISVSFAVDKEGITINVDDDGPGVSQADREQIFRPFYRTDEARDreSGGTGLGLAIVETAVQ 429
Cdd:cd16950 1 LKRVLSNLVDNALRYGGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQRISD 78
|
90 100
....*....|....*....|...
gi 495054612 430 QHRGWVKADDSPLGGLRLTLWLP 452
Cdd:cd16950 79 AHGGSLTLANRAGGGLCARIELP 101
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
189-433 |
3.04e-23 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 100.45 E-value: 3.04e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 189 PARKLKNAADEVAQGNLrqhpELEAGPQEFIAAGAS-----FNQMVTALERMMTTQQRLLSDISHELRTPLT----RLQ- 258
Cdd:NF012226 87 PINFLADAAKKISQGDL----SARAEDSQIHSAEISelmhnFNDMAQKLESSVKNAQVWNAAIAHELRTPITilqgRLQg 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 259 -----------LGTALLRRRSGESKELERIETeahrldsmindlLVMSRNQQ------KNALVSETMKANQIWGEVLDNA 321
Cdd:NF012226 163 ildgvfepdpaLFKSLLNQVEGLSHLVEDLRT------------LSLVENQQlrlnyeSVDLKDSIEKVLKMFEDRLEQA 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 322 AFEAEqmgksFEVTYPPgpwlLYGNPNALESALENIVRNALRYSHS-KISVSFAVDKEGITINVDDDGPGVSQADREQIF 400
Cdd:NF012226 231 QLTIV-----LNLTATP----VFCDRRRIEQVLIALIDNAIRYANAgKLKISSSVIQDDWILQIEDEGPGIAEEYQQDLF 301
|
250 260 270
....*....|....*....|....*....|...
gi 495054612 401 RPFYRTDEARDRESGGTGLGLAIVETAVQQHRG 433
Cdd:NF012226 302 NPFFRLEQSRNKEFGGTGLGLAVVHAIVIAHKG 334
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
238-452 |
2.44e-22 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 98.93 E-value: 2.44e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 238 TQQRLL--------SDISHELRTPLTRLQLGTALLRRRSGES----KELERIETEAHRLDSMINDLLVMSRNQqknalVS 305
Cdd:PRK11006 195 TQMHQLegarrnffANVSHELRTPLTVLQGYLEMMQDQPLEGalreKALHTMREQTQRMEGLVKQLLTLSKIE-----AA 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 306 ETMKANqiwgEVLDNAAF------EAEQMG-KSFEVTYPPGPWL-LYGNPNALESALENIVRNALRYS--HSKISVSFAV 375
Cdd:PRK11006 270 PTIDLN----EKVDVPMMlrvlerEAQTLSqGKHTITFEVDNSLkVFGNEDQLRSAISNLVYNAVNHTpeGTHITVRWQR 345
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 376 DKEGITINVDDDGPGVSQadrEQIFR---PFYRTDEARDRESGGTGLGLAIVETAVQQHRGWVKADDSPLGGLRLTLWLP 452
Cdd:PRK11006 346 VPQGAEFSVEDNGPGIAP---EHIPRlteRFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLP 422
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
329-446 |
9.00e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 90.77 E-value: 9.00e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 329 GKSFEVTYPPGpWLLYGNPNALESALENIVRNALRYSHSKISVSFAVDKEGITINVDDDGPGVSQADREQIFRPFYRTDE 408
Cdd:cd16954 18 GVSISLDISPE-LRFPGERNDLMELLGNLLDNACKWCLEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDE 96
|
90 100 110
....*....|....*....|....*....|....*...
gi 495054612 409 ARDresgGTGLGLAIVETAVQQHRGWVKADDSPLGGLR 446
Cdd:cd16954 97 QRP----GQGLGLAIAKEIVEQYGGELSLSDSPLGGAR 130
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
203-453 |
6.72e-20 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 92.79 E-value: 6.72e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 203 GNLRQH--PELEAGPQEFIAAGASfnqmvtALERMMTTQQR---------------LLSDISHELRTPLTRLqLGTA--- 262
Cdd:PRK10490 617 GNLRQLmiPEQQRLLETFTLLIAN------ALERLTLTASEeqarlasereqlrnaLLAALSHDLRTPLTVL-FGQAeil 689
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 263 ---LLRRRSGESKELERIETEAHRLDSMINDLLVMSRNQQKN-ALVSETMKANQIWGEVLdnAAFEAEQMGKSFEVTYPP 338
Cdd:PRK10490 690 tldLASEGSPHARQASEIRQQVLNTTRLVNNLLDMARIQSGGfNLRKEWLTLEEVVGSAL--QMLEPGLSGHPINLSLPE 767
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 339 GPWLLYGNPNALESALENIVRNALRYSHSK--ISVSFAVDKEGITINVDDDGPGVSQADREQIFRPFYRTDeardRESG- 415
Cdd:PRK10490 768 PLTLIHVDGPLFERVLINLLENAVKYAGAQaeIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGN----KESAi 843
|
250 260 270
....*....|....*....|....*....|....*....
gi 495054612 416 -GTGLGLAIVETAVQQHRGWVKADDSPLGGLRLTLWLPL 453
Cdd:PRK10490 844 pGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLPL 882
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
232-433 |
1.10e-19 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 91.19 E-value: 1.10e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 232 LERMMTTQQRL------LSDISHELRTPLTRL----QLgtaLLRRRSGESKE-LERIETEAHRLDSMINDLLVMSRNQqk 300
Cdd:COG5809 257 LEELLRKSEKLsvvgelAAGIAHEIRNPLTSLkgfiQL---LKDTIDEEQKTyLDIMLSELDRIESIISEFLVLAKPQ-- 331
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 301 nALVSETMKANQIWGEVLDnaAFEAEQMGKSFEVTY------PPgpwlLYGNPNALESALENIVRNALRY--SHSKISVS 372
Cdd:COG5809 332 -AIKYEPKDLNTLIEEVIP--LLQPQALLKNVQIELeleddiPD----ILGDENQLKQVFINLLKNAIEAmpEGGNITIE 404
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 495054612 373 -FAVDKEGITINVDDDGPGVSQADREQIFRPFYRTDEardresGGTGLGLAIVETAVQQHRG 433
Cdd:COG5809 405 tKAEDDDKVVISVTDEGCGIPEERLKKLGEPFYTTKE------KGTGLGLMVSYKIIEEHGG 460
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
232-453 |
3.45e-19 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 89.46 E-value: 3.45e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 232 LERMMTTQQRLLS------DISHELRTPLTRLQ-LGTALLRR--RSGESKEL-ERIETEAHRLDSMINDLLVMSRNQQkn 301
Cdd:PRK10364 224 LQDEMKRKEKLVAlghlaaGVAHEIRNPLSSIKgLAKYFAERapAGGEAHQLaQVMAKEADRLNRVVSELLELVKPTH-- 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 302 aLVSETMKANQIWGEVLDNAAFEAEQMGKSFEVTYPPGPWLLYGNPNALESALENIVRNALRY--SHSKISVSFAVDKEG 379
Cdd:PRK10364 302 -LALQAVDLNDLINHSLQLVSQDANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAigQHGVISVTASESGAG 380
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 495054612 380 ITINVDDDGPGVSQADREQIFRPFYRTdeardrESGGTGLGLAIVETAVQQHRGWVKADDSPLGGLRLTLWLPL 453
Cdd:PRK10364 381 VKISVTDSGKGIAADQLEAIFTPYFTT------KAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPV 448
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
346-450 |
1.21e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 80.97 E-value: 1.21e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 346 NPNALESALENIVRNALRYSHSK--ISVSFAVDKEGITINVDDDGPGVSQADREQIFRPFYRTDEARDreSGG-TGLGLA 422
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGgtVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRR--SGGhYGMGLY 78
|
90 100
....*....|....*....|....*...
gi 495054612 423 IVETAVQQHRGWVKADDSPLGGLRLTLW 450
Cdd:cd16975 79 IAKNLVEKHGGSLIIENSQKGGAEVTVK 106
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
215-449 |
2.24e-18 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 87.01 E-value: 2.24e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 215 PQEFIAAGASFNQMVTALERMMTTQQRLLSDISHELRTPLTRLQLGT--ALLRRRSGESKE--LERIETEAHRLDSMIND 290
Cdd:PRK10337 213 PSEVRPLVEALNQLFARTHAMMVRERRFTSDAAHELRSPLAALKVQTevAQLSDDDPQARKkaLLQLHAGIDRATRLVDQ 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 291 LLVMSRNQQKNALvsETMKANQiWGEVLDNAAFE----AEQMGKSFEVTYPPGPWLLYGNPNALESALENIVRNALRYSH 366
Cdd:PRK10337 293 LLTLSRLDSLDNL--QDVAEIP-LEDLLQSAVMDiyhtAQQAGIDVRLTLNAHPVIRTGQPLLLSLLVRNLLDNAIRYSP 369
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 367 SKISVSFAVDKEGITinVDDDGPGVSQADREQIFRPFYRTDearDRESGGTGLGLAIVETAVQQHRGWVKADDSPLGGLR 446
Cdd:PRK10337 370 QGSVVDVTLNARNFT--VRDNGPGVTPEALARIGERFYRPP---GQEATGSGLGLSIVRRIAKLHGMNVSFGNAPEGGFE 444
|
...
gi 495054612 447 LTL 449
Cdd:PRK10337 445 AKV 447
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
217-453 |
2.33e-18 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 86.44 E-value: 2.33e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 217 EFIAAGASFNQmVTALERMMT--TQQRLLSDI----SHELRTpltRLQLGTALLRrrSGESKELER-IETEAHRLDSMIN 289
Cdd:COG3290 162 RVVGAVATFRD-RTELERLEEelEGVKELAEAlraqRHDFRN---HLHTISGLLQ--LGEYDEALEyIDEISEELQELID 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 290 DLLVMSRNQQKNALVSEtmKANqiwgevldnaafEAEQMGKSFEVTYPPGPWLLYGNPNALESALENIVRNALRY----- 364
Cdd:COG3290 236 SLLSRIGNPVLAALLLG--KAA------------RARERGIDLTIDIDSDLPDLPLSDTDLVTILGNLLDNAIEAveklp 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 365 -SHSKISVSFAVDKEGITINVDDDGPGVSQADREQIFRPFYRTdeardRESGGTGLGLAIVETAVQQHRGWVKADDSPLG 443
Cdd:COG3290 302 eEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFST-----KLGEGRGLGLALVKQIVEKYGGTIEVESEEGE 376
|
250
....*....|
gi 495054612 444 GLRLTLWLPL 453
Cdd:COG3290 377 GTVFTVRLPK 386
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
345-451 |
4.37e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 76.68 E-value: 4.37e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 345 GNPNALESALENIVRNALRYSHSKISVSFAVDKE-GITINVDDDGPGVSQADREQIFRPFYRTDEardRESGGTGLGLAI 423
Cdd:cd16940 9 GDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADdGAVIRVEDNGPGIDEEELEALFERFYRSDG---QNYGGSGLGLSI 85
|
90 100
....*....|....*....|....*...
gi 495054612 424 VETAVQQHRGWVKADDSPLGGLRLTLWL 451
Cdd:cd16940 86 VKRIVELHGGQIFLGNAQGGGLEAWVRL 113
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
206-447 |
6.66e-17 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 82.76 E-value: 6.66e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 206 RQHPELEAG---------PQEFIAAGASFNQMVTAlERMMTTQQRL-LSDISHELRTPLTRLQlgTALLRRRSG-----E 270
Cdd:PRK10815 224 KQVRELEEGereqldpnpPRELTSLVRNLNRLLKN-ERERYTKYRTtLTDLTHSLKTPLAVLQ--STLRSLRSGkqmsvE 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 271 SKE---LERIETEA-------HRLdSMINDLLVMSRNQQK-----NALVSETMKANQIWGEVLdnaafeaeQMGKSFEVT 335
Cdd:PRK10815 301 QAEpimLEQISRISqqigyylHRA-SMRSEHNLLSRELHSvapllDNLTSALNKVYQRKGVNI--------TLDISPEIT 371
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 336 yppgpWLlyGNPNALESALENIVRNALRYSHSKISVSFAVDKEGITINVDDDGPGVSQADREQIFRPFYRTDEARDresg 415
Cdd:PRK10815 372 -----FV--GEKNDFMEVMGNVLDNACKYCLEFVEISARQTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRP---- 440
|
250 260 270
....*....|....*....|....*....|..
gi 495054612 416 GTGLGLAIVETAVQQHRGWVKADDSPLGGLRL 447
Cdd:PRK10815 441 GQGLGLSVAREITEQYEGKISAGDSPLGGARM 472
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
224-452 |
9.84e-17 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 82.87 E-value: 9.84e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 224 SFNQMVTALERMMTTQQRLLSDISHELRTP-------LTRLQLGTAllrrrSGESKE-LERIETEAHRLDSMINDLLVMS 295
Cdd:TIGR03785 470 SFAQMVARLRQYTHYLENMSSRLSHELRTPvavvrssLENLELQAL-----EQEKQKyLERAREGTERLSMILNNMSEAT 544
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 296 RNQQKnalVSETMKANQIWGEVLdNAAFEAEQM---GKSFEVTYPPGPWLLYGNPNALESALENIVRNALRYSHSK--IS 370
Cdd:TIGR03785 545 RLEQA---IQSAEVEDFDLSEVL-SGCMQGYQMtypPQRFELNIPETPLVMRGSPELIAQMLDKLVDNAREFSPEDglIE 620
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 371 VSFAVDKEGITINVDDDGPGVSQADREQIFRPFYRTDEARDRESGGTGLGLAIVETAVQQHRGWVKADDSPLG-GLRLTL 449
Cdd:TIGR03785 621 VGLSQNKSHALLTVSNEGPPLPEDMGEQLFDSMVSVRDQGAQDQPHLGLGLYIVRLIADFHQGRIQAENRQQNdGVVFRI 700
|
...
gi 495054612 450 WLP 452
Cdd:TIGR03785 701 SLP 703
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-452 |
1.06e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 75.70 E-value: 1.06e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 350 LESALENIVRNALRYS--HSKISVSFAVDKEGITINVDDDGPGVSQADREQIFRPFYRTDEARDRESGGTGLGLAIVETA 427
Cdd:cd16952 1 LRSAFSNLVSNAVKYTppSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHV 80
|
90 100
....*....|....*....|....*
gi 495054612 428 VQQHRGWVKADDSPLGGLRLTLWLP 452
Cdd:cd16952 81 MSRHDARLLIASELGKGSRFTCLFP 105
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
229-453 |
1.07e-16 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 82.32 E-value: 1.07e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 229 VTALERMMTTQQR---------LLSDISHELRTPLTRLQLGTALLRR---RSGESKELERIETEAHRLDSMINDLLVMSR 296
Cdd:PRK11360 371 LTERKRLQRRVARqerlaalgeLVAGVAHEIRNPLTAIRGYVQIWRQqtsDPPSQEYLSVVLREVDRLNKVIDQLLEFSR 450
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 297 -----NQQK--NALVSETMKANQIWGeVLDNAAFEAEqmgksFEVTYPPgpwlLYGNPNALESALENIVRNALRYSHSKI 369
Cdd:PRK11360 451 presqWQPVslNALVEEVLQLFQTAG-VQARVDFETE-----LDNELPP----IWADPELLKQVLLNILINAVQAISARG 520
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 370 SVSFAVDKEG---ITINVDDDGPGVSQADREQIFRPFYRTdeardrESGGTGLGLAIVETAVQQHRGWVKADDSPLGGLR 446
Cdd:PRK11360 521 KIRIRTWQYSdgqVAVSIEDNGCGIDPELLKKIFDPFFTT------KAKGTGLGLALSQRIINAHGGDIEVESEPGVGTT 594
|
....*..
gi 495054612 447 LTLWLPL 453
Cdd:PRK11360 595 FTLYLPI 601
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
346-452 |
1.20e-15 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 72.53 E-value: 1.20e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 346 NPNALESALENIVRNALRYSHSKISVSFAVDK---EGITINVDDDGPGVSQADREQIFRPFYRTDEARDRESGGTGLGLA 422
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKfrlNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80
|
90 100 110
....*....|....*....|....*....|
gi 495054612 423 IVETAVQQHRGWVKADDSPLGGLRLTLWLP 452
Cdd:cd16925 81 IVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
233-453 |
4.23e-15 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 77.76 E-value: 4.23e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 233 ERMMTTQQRLLSDISHELRTPLTRLQLGTALLRRRSGESKELERIETeAHR----LDSMINDLLVMSR--------NQQK 300
Cdd:PRK15347 392 EQANKRKSEHLTTISHEIRTPLNGVLGALELLQNTPLTAEQMDLADT-ARQctlsLLAIINNLLDFSRiesgqmtlSLEE 470
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 301 NALVsetmkanqiwgEVLDNAAFEAEQMGKSFEVTY-----PPGPWLLYGNPNALESALENIVRNALRY-SHSKISVSFA 374
Cdd:PRK15347 471 TALL-----------PLLDQAMLTIQGPAQSKSLTLrtfvgAHVPLYLHLDSLRLRQILVNLLGNAVKFtETGGIRLRVK 539
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495054612 375 VDKEGITINVDDDGPGVSQADREQIFRPFYRTDEardrESGGTGLGLAIVETAVQQHRGWVKADDSPLGGLRLTLWLPL 453
Cdd:PRK15347 540 RHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADT----HSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLPL 614
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
231-456 |
1.30e-14 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 76.25 E-value: 1.30e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 231 ALERMMTTQQRL------LSDISHE----LRTPLTRLQLGTALLRRRSGESKELERIETEAHRLDSMINDLLVMSRnqqK 300
Cdd:PRK13837 436 ALERRLEHARRLeavgtlASGIAHNfnniLGAILGYAEMALNKLARHSRAARYIDEIISAGARARLIIDQILAFGR---K 512
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 301 NALVSETMKANQIWGEVLDNAAFeAEQMGKSFEVTYPPGPWLLYGNPNALESALENIVRNALRYSHSKISVSFAVDKEGI 380
Cdd:PRK13837 513 GERNTKPFDLSELVTEIAPLLRV-SLPPGVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDISLSRAKL 591
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 381 T-----------------INVDDDGPGVSQADREQIFRPFYRTdeardrESGGTGLGLAIVETAVQQHRGWVKADDSPLG 443
Cdd:PRK13837 592 RapkvlshgvlppgryvlLRVSDTGAGIDEAVLPHIFEPFFTT------RAGGTGLGLATVHGIVSAHAGYIDVQSTVGR 665
|
250
....*....|...
gi 495054612 444 GLRLTLWLPLYHR 456
Cdd:PRK13837 666 GTRFDVYLPPSSK 678
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
246-453 |
1.49e-14 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 75.54 E-value: 1.49e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 246 ISHELRTPLTR----LQLgtaLLRRRSGESKELERIETEAHRLDSMINDLLVMSRNQqknALVSETMKANQIWGEV---- 317
Cdd:COG5805 294 IAHEIRNPLTSikgfLQL---LQPGIEDKEEYFDIMLSELDRIESIISEFLALAKPQ---AVNKEKENINELIQDVvtll 367
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 318 -----LDNAAFEAEQMGKSFEVtyppgpwllYGNPNALESALENIVRNALRY--SHSKISVSFAVDKEGITINVDDDGPG 390
Cdd:COG5805 368 eteaiLHNIQIRLELLDEDPFI---------YCDENQIKQVFINLIKNAIEAmpNGGTITIHTEEEDNSVIIRVIDEGIG 438
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 495054612 391 VSQADREQIFRPFYRTDEArdresgGTGLGLAIVETAVQQHRGWVKADDSPLGGLRLTLWLPL 453
Cdd:COG5805 439 IPEERLKKLGEPFFTTKEK------GTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPL 495
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
354-453 |
7.60e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 67.52 E-value: 7.60e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 354 LENIVRNALRYSHsKISVSFAVDKEG-------ITINVDDDGPGVSQADREQIFRPFYRTDEARDRESGGTGLGLAIVET 426
Cdd:cd16922 5 LLNLLGNAIKFTE-EGEVTLRVSLEEeeedgvqLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAISKK 83
|
90 100 110
....*....|....*....|....*....|
gi 495054612 427 AVQQHRG--WVKaddSPLG-GLRLTLWLPL 453
Cdd:cd16922 84 LVELMGGdiSVE---SEPGqGSTFTFTLPL 110
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
243-437 |
8.36e-14 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 74.04 E-value: 8.36e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 243 LSDISHELRTPLTRLqLGTALLRRRSG----ESKELERIETEAHRLDSMINDLLVMSRNQQKNALVSET-MKANQIWGEV 317
Cdd:TIGR02956 468 LATMSHEIRTPLNGI-LGTLELLGDTGltsqQQQYLQVINRSGESLLDILNDILDYSKIEAGHLSISPRpFDLNALLDDV 546
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 318 LDNAAFEAEQMGKSFEVTYP---PGPWLlyGNPNALESALENIVRNALRYSHS-KISVSFAVDKEG-ITINVDDDGPGVS 392
Cdd:TIGR02956 547 HHLMVSRAQLKGIQLRLNIPeqlPNWWQ--GDGPRIRQVLINLVGNAIKFTDRgSVVLRVSLNDDSsLLFEVEDTGCGIA 624
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 495054612 393 QADREQIFRPFYRTDEArdRESGGTGLGLAIVETAVQQHRG--WVKA 437
Cdd:TIGR02956 625 EEEQATLFDAFTQADGR--RRSGGTGLGLAISQRLVEAMDGelGVES 669
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
236-296 |
8.90e-14 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 65.70 E-value: 8.90e-14
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 495054612 236 MTTQQRLLSDISHELRTPLTRLQLGTALLRRRSGESKE----LERIETEAHRLDSMINDLLVMSR 296
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEqreyLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
347-453 |
2.04e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 66.29 E-value: 2.04e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 347 PNALESALENIVRNALRY--SHSKISVSFAVDKEGITINVDDDGPGVSQADREQIFRPFYRTDEARDresgGTGLGLAIV 424
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQAmeGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGE----GTGLGLSLS 76
|
90 100
....*....|....*....|....*....
gi 495054612 425 ETAVQQHRGWVKADDSPLGGLRLTLWLPL 453
Cdd:cd16943 77 YRIIQKHGGTIRVASVPGGGTRFTIILPI 105
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
239-299 |
3.07e-13 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 64.54 E-value: 3.07e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 495054612 239 QQRLLSDISHELRTPLTRLQLGTALLRRR--SGESKE-LERIETEAHRLDSMINDLLVMSRNQQ 299
Cdd:pfam00512 2 KSEFLANLSHELRTPLTAIRGYLELLRDEklDEEQREyLETILRSAERLLRLINDLLDLSRIEA 65
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-433 |
7.79e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 64.33 E-value: 7.79e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 350 LESALENIVRNALRYSHSKISVSFAVDKEGITINVDDDGPGVSQADR--EQIFRPFYRTDEARDreSGGTGLGLAIVETA 427
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFklEKLFERFYRGDNSRN--TEGAGLGLSIAKAI 78
|
....*.
gi 495054612 428 VQQHRG 433
Cdd:cd16923 79 IELHGG 84
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
239-299 |
8.25e-13 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 62.97 E-value: 8.25e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 495054612 239 QQRLLSDISHELRTPLTRLQLGTALLRRRSGESKE---LERIETEAHRLDSMINDLLVMSRNQQ 299
Cdd:smart00388 2 KREFLANLSHELRTPLTAIRGYLELLLDTELSEEQreyLETILREAERLLRLINDLLDLSRIEA 65
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
348-452 |
1.17e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 63.85 E-value: 1.17e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 348 NALESALenivrnALRYSHSKISVSFAVDKEGITINVDDDGPGVSQADREQIFRPFYRTDEARDResggtGLGLAIVETA 427
Cdd:cd16915 11 NALDALA------ATGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQGER-----GIGLALVRQS 79
|
90 100
....*....|....*....|....*
gi 495054612 428 VQQHRGWVKADDSPLGGLRLTLWLP 452
Cdd:cd16915 80 VERLGGSITVESEPGGGTTFSIRIP 104
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-452 |
1.30e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 63.89 E-value: 1.30e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 350 LESALENIVRNALRYSHSK----ISVSFAVDKEGITINVDDDGPGVSQADREQIFRPFYRTDEarDRESGGTGLGLAIVE 425
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRrpprIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHS--REEYEGTGVGLAIVR 78
|
90 100
....*....|....*....|....*..
gi 495054612 426 TAVQQHRGWVKADDSPLGGLRLTLWLP 452
Cdd:cd16921 79 KIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
243-455 |
3.78e-12 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 68.78 E-value: 3.78e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 243 LSDISHELRTPLTRLqLGTALL---RRRSGESKE-LERIETEAHRLDSMINDLLVMSRNQQKNALVS---ETMKANQIWG 315
Cdd:PRK11466 448 LAAMSHEIRTPLYGI-LGTAQLladNPALNAQRDdLRAITDSGESLLTILNDILDYSAIEAGGKNVSvsdEPFEPRPLLE 526
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 316 EVLDNAAFEAEQMGKSFEVTYPPG-PWLLYGNPNALESALENIVRNALRYS-HSKISVSFAVDKEGITINVDDDGPGVSQ 393
Cdd:PRK11466 527 STLQLMSGRVKGRPIRLATDIADDlPTALMGDPRRIRQVITNLLSNALRFTdEGSIVLRSRTDGEQWLVEVEDSGCGIDP 606
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 495054612 394 ADREQIFRPFYRTDEARdresGGTGLGLAIVETAVQQHRGWVKADDSPLGGLRLTLWLPLYH 455
Cdd:PRK11466 607 AKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPLRV 664
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
333-441 |
4.90e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 62.92 E-value: 4.90e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 333 EVTYPPGPWLLYGNPNALESALENIVRNALRYSHSK--ISVSFAVDKEGITINVDDDGPGVSQADREQIFRPFYRTDEAR 410
Cdd:cd16947 4 EINIPDRPIYANANTEALQRILKNLISNAIKYGSDGkfLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSR 83
|
90 100 110
....*....|....*....|....*....|.
gi 495054612 411 DRESGGTGLGLAIVETAVQQHRGWVKADDSP 441
Cdd:cd16947 84 NSAKQGNGLGLTITKRLAESMGGSIYVNSKP 114
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-441 |
7.93e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 61.65 E-value: 7.93e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 350 LESALENIVRNA---LRYSHSKI----SVSFAVD------KEGITINVDDDGPGVSQADREQIFRPFYRTDEardresGG 416
Cdd:cd16918 1 LIQVFLNLVRNAaqaLAGSGGEIilrtRTQRQVTlghprhRLALRVSVIDNGPGIPPDLQDTIFYPMVSGRE------NG 74
|
90 100
....*....|....*....|....*
gi 495054612 417 TGLGLAIVETAVQQHRGWVKADDSP 441
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGVIECDSQP 99
|
|
| nifL_nitrog |
TIGR02938 |
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation ... |
340-453 |
8.64e-12 |
|
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions]
Pssm-ID: 131984 [Multi-domain] Cd Length: 494 Bit Score: 66.85 E-value: 8.64e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 340 PWLLyGNPNALESALENIVRNAL------RYSHSKISVSFAVDKEGITINVDDDGPGVSQADREQIFRPFYRTDEARDRe 413
Cdd:TIGR02938 379 PAIL-GRELQLRSLFKALVDNAIeamnikGWKRRELSITTALNGDLIVVSILDSGPGIPQDLRYKVFEPFFTTKGGSRK- 456
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 495054612 414 sgGTGLGLAIVETAVQQHRGWVKADDSPLGGLRLTLWLPL 453
Cdd:TIGR02938 457 --HIGMGLSVAQEIVADHGGIIDLDDDYSEGCRIIVEFRV 494
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
239-453 |
1.19e-11 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 67.07 E-value: 1.19e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 239 QQRLLSDISHELRTPLTRLqLGTALLRRRSGESKElERIETEAhrldsmindlLVMSRNQQKNALVSETMKANQI----- 313
Cdd:PRK09959 712 KSQFLATMSHEIRTPISSI-MGFLELLSGSGLSKE-QRVEAIS----------LAYATGQSLLGLIGEILDVDKIesgny 779
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 314 -----WGEV---LDNA--AFEAEQMGKSFEVTYP---PGPWLLYGNPNALESALENIVRNALRYSHS---KISVSFA-VD 376
Cdd:PRK09959 780 qlqpqWVDIptlVQNTchSFGAIAASKSIALSCSstfPDHYLVKIDPQAFKQVLSNLLSNALKFTTEgavKITTSLGhID 859
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495054612 377 KEG--ITINVDDDGPGVSQADREQIFRPFYRTDEArdRESGGTGLGLAIVETAVQQHRGWVKADDSPLGGLRLTLWLPL 453
Cdd:PRK09959 860 DNHavIKMTIMDSGSGLSQEEQQQLFKRYSQTSAG--RQQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIPV 936
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
239-454 |
5.16e-11 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 64.20 E-value: 5.16e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 239 QQRLLSDISHELRTPLT-------RLQLGtalLRRRSGESKE--LERIETEAHR----LDSMINDLLVMSR--------N 297
Cdd:PRK09303 151 KDRVLAMLAHDLRTPLTaaslaleTLELG---QIDEDTELKPalIEQLQDQARRqleeIERLITDLLEVGRtrwealrfN 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 298 QQKNALVSetmkanqIWGEVLDNaaFEAEQMGKSFEVTY--PPGPWLLYGNPNALESALENIVRNALRYS--HSKISVSf 373
Cdd:PRK09303 228 PQKLDLGS-------LCQEVILE--LEKRWLAKSLEIQTdiPSDLPSVYADQERIRQVLLNLLDNAIKYTpeGGTITLS- 297
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 374 AVDK--EGITINVDDDGPGVSQADREQIFRPFYRTDeaRDRESGGTGLGLAIVETAVQQHRG--WVkaDDSPLGGLRLTL 449
Cdd:PRK09303 298 MLHRttQKVQVSICDTGPGIPEEEQERIFEDRVRLP--RDEGTEGYGIGLSVCRRIVRVHYGqiWV--DSEPGQGSCFHF 373
|
....*
gi 495054612 450 WLPLY 454
Cdd:PRK09303 374 TLPVY 378
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-452 |
9.71e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 58.56 E-value: 9.71e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 350 LESALENIVRNALRY------SHSKISVSFAV-DKEGITINVDDDGPGVSQADREQIFRPFYRTdeardrESGGTGLGLA 422
Cdd:cd16920 1 IQQVLINLVRNGIEAmseggcERRELTIRTSPaDDRAVTISVKDTGPGIAEEVAGQLFDPFYTT------KSEGLGMGLS 74
|
90 100 110
....*....|....*....|....*....|
gi 495054612 423 IVETAVQQHRGWVKADDSPLGGLRLTLWLP 452
Cdd:cd16920 75 ICRSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
346-451 |
2.03e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 57.86 E-value: 2.03e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 346 NPNALESALENIVRNALRYS--HSKISVSFAVDKEGITINVDDDGPGVSQADREQIFRPFYRTDEARDRESGgTGLGLAI 423
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSpeGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQKS-TGLGLAF 79
|
90 100
....*....|....*....|....*...
gi 495054612 424 VETAVQQHRGWVKADDSPLGGLRlTLWL 451
Cdd:cd16945 80 VQEVAQLHGGRITLRNRPDGVLA-FLTL 106
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
224-455 |
2.24e-10 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 63.07 E-value: 2.24e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 224 SFNQMVTALERMMTTQQRLLSDISHELRTPLTRLQLGTALLRrrsgeSKELERietEAHRLdsmindllVMSRNQQKNAL 303
Cdd:PRK10841 432 SLQEMAQAAEQASQSKSMFLATVSHELRTPLYGIIGNLDLLQ-----TKELPK---GVDRL--------VTAMNNSSSLL 495
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 304 VsetmkanQIWGEVLDNAAFEAEQMG---KSF---EV------TY----------------PPGPWLLYGNPNALESALE 355
Cdd:PRK10841 496 L-------KIISDILDFSKIESEQLKiepREFsprEVinhitaNYlplvvkkrlglycfiePDVPVALNGDPMRLQQVIS 568
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 356 NIVRNALRYSHSK-ISVSFAVDKEGITINVDDDGPGVSQADREQIFRPFYRTDEARDRESGGTGLGLAIVETAVQQHRGW 434
Cdd:PRK10841 569 NLLSNAIKFTDTGcIVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMDGD 648
|
250 260
....*....|....*....|.
gi 495054612 435 VKADDSPLGGLRLTLWLPLYH 455
Cdd:PRK10841 649 ISVDSEPGMGSQFTIRIPLYG 669
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
243-430 |
1.05e-09 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 61.02 E-value: 1.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 243 LSDISHELRTPL------TRLQLGTALlrrRSGESKELERIETEAHRLDSMINDLLVMSRnQQKNALVSETMKAN--QIW 314
Cdd:PRK11107 297 LANMSHELRTPLngvigfTRQTLKTPL---TPTQRDYLQTIERSANNLLAIINDILDFSK-LEAGKLVLENIPFSlrETL 372
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 315 GEV---LDNAAFEaeqmgKSFEVTY---PPGPWLLYGNPNALESALENIVRNALRYSHS---KISVSF-AVDKEGITINV 384
Cdd:PRK11107 373 DEVvtlLAHSAHE-----KGLELTLnidPDVPDNVIGDPLRLQQIITNLVGNAIKFTESgniDILVELrALSNTKVQLEV 447
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 495054612 385 D--DDGPGVSQADREQIFRPFYRTDEARDRESGGTGLGLAIVETAVQQ 430
Cdd:PRK11107 448 QirDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQKLVNE 495
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-451 |
1.90e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 54.77 E-value: 1.90e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 350 LESALENIVRNALRYSHS----KISVSFAVDKEGITINVDDDGPGVSQADREQIFRPFYRTdeardRESG-GTGLGLAIV 424
Cdd:cd16976 1 IQQVLMNLLQNALDAMGKvenpRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTT-----KPVGkGTGLGLSIS 75
|
90 100
....*....|....*....|....*..
gi 495054612 425 ETAVQQHRGWVKADDSPLGGLRLTLWL 451
Cdd:cd16976 76 YGIVEEHGGRLSVANEEGAGARFTFDL 102
|
|
| CpxA_peri |
pfam16527 |
Two-component sensor protein CpxA, periplasmic domain; CpxA_peri is the periplasmic ... |
81-144 |
3.68e-09 |
|
Two-component sensor protein CpxA, periplasmic domain; CpxA_peri is the periplasmic domain-family of the Gram-negative Gammaproteobacteria two-component signalling system, Cpx. It represents the recognition-site for sensing specific envelope stress signals. The fold that the domain-core of CpxA_peri conforms to is a PAS fold. The domain senses the environmental change and triggers a signal transduction to the cytoplasmic domain. As well as the PAS-core, there is a C-terminal tail that is necessary for ligand-sensing and binding to CpxP, a CpxA-associated and a regulatory protein. This domain recognizes KCl and RbCl (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 435400 [Multi-domain] Cd Length: 134 Bit Score: 54.74 E-value: 3.68e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 495054612 81 PGQRLLLVTSEGRVIGAERN---EMQIIRNFIGQSDNSDHPQKKKYGRVELVGPFSVRDGEDNYQLY 144
Cdd:pfam16527 51 GRPRFFFTDYEGEILTTKRRsdfRLKALRNFVTSIEDPQKPQQKLYGRYMMAGPVPITLADQTLLMY 117
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-452 |
9.34e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 52.96 E-value: 9.34e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 350 LESALENIVRNALRYS---HSKISVSFAVDKEGITINVDDDGPGVSQADREQIFRPFYRTDEARDRESGGTGLGLAIVET 426
Cdd:cd16953 1 LGQVLRNLIGNAISFSppdTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQHSGLGLSISRQ 80
|
90 100 110
....*....|....*....|....*....|
gi 495054612 427 AVQQHRGWVKA----DDSPLGGLRLTLWLP 452
Cdd:cd16953 81 IIEAHGGISVAenhnQPGQVIGARFTVQLP 110
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-452 |
2.48e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 51.77 E-value: 2.48e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 349 ALESALENIVRNA--------LRYSHSKISVSFAVDkEGITINVDDDGPGVSQADREQIFRPFYRTDEArdresgGTGLG 420
Cdd:cd16944 4 QISQVLTNILKNAaeaiegrpSDVGEVRIRVEADQD-GRIVLIVCDNGKGFPREMRHRATEPYVTTRPK------GTGLG 76
|
90 100 110
....*....|....*....|....*....|..
gi 495054612 421 LAIVETAVQQHRGWVKADDSPLGGLRLTLWLP 452
Cdd:cd16944 77 LAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
343-453 |
2.78e-08 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 55.47 E-value: 2.78e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 343 LYGNPNALESALENIVRNA---LRYSHSKISV----SFAVDKEGI------TINVDDDGPGVSQADREQIFRPFYRTDEa 409
Cdd:PRK11073 231 LAHDPDQIEQVLLNIVRNAlqaLGPEGGTITLrtrtAFQLTLHGEryrlaaRIDIEDNGPGIPPHLQDTLFYPMVSGRE- 309
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 495054612 410 rdresGGTGLGLAIVETAVQQHRGWVKADDSPlGGLRLTLWLPL 453
Cdd:PRK11073 310 -----GGTGLGLSIARNLIDQHSGKIEFTSWP-GHTEFSVYLPI 347
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
350-452 |
5.47e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 50.84 E-value: 5.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 350 LESALENIVRNA---------LRYSHSKISVSFAVDK------EG--ITINVDDDGPGVSQADREQIFRPFYRTDEardr 412
Cdd:cd16919 1 LELAILNLAVNArdampeggrLTIETSNQRVDADYALnyrdliPGnyVCLEVSDTGSGMPAEVLRRAFEPFFTTKE---- 76
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 495054612 413 ESGGTGLGLAIVETAVQQHRGWVKADDSPLGGLRLTLWLP 452
Cdd:cd16919 77 VGKGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
246-433 |
1.01e-07 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 54.31 E-value: 1.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 246 ISHELRTPLTRL-----QLGTALLRRRSGESKE-LERIETEAHRLDSMINDLLVMSRNQQKNA-LVSETMKANQIWGEVL 318
Cdd:COG4192 440 LAHELNQPLNAMsmylfSAKKALEQENYAQLPTsLDKIEGLIERMDKIIKSLRQFSRKSDTPLqPVDLRQVIEQAWELVE 519
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 319 DNAAFEAEQMgksfevTYPPGPWLLyGNPNALESALENIVRNALRYS--HSKISVSFAVDKEGITINVDDDGPGVSQADR 396
Cdd:COG4192 520 SRAKPQQITL------HIPDDLMVQ-GDQVLLEQVLVNLLVNALDAVatQPQISVDLLSNAENLRVAISDNGNGWPLVDK 592
|
170 180 190
....*....|....*....|....*....|....*..
gi 495054612 397 eqIFRPFYRTDEArdresgGTGLGLAIVETAVQQHRG 433
Cdd:COG4192 593 --LFTPFTTTKEV------GLGLGLSICRSIMQQFGG 621
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
231-453 |
1.84e-07 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 53.41 E-value: 1.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 231 ALERMMTTQQRLLSDISHELRTP------LTRLQLGTALlrrRSGESKELERIETEAHRLDSMINDLLVMSR-NQQKNAL 303
Cdd:PRK11091 275 ALEKASRDKTTFISTISHELRTPlngivgLSRILLDTEL---TAEQRKYLKTIHVSAITLGNIFNDIIDMDKmERRKLQL 351
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 304 VSETMKANQIWGEVLDNAAFEAEQMGKSFEV-TYPPGPWLLYGNPNALESALENIVRNALRYSHS-KISVSFAVD-KEGI 380
Cdd:PRK11091 352 DNQPIDFTDFLADLENLSGLQAEQKGLRFDLePLLPLPHKVITDGTRLRQILWNLISNAVKFTQQgGVTVRVRYEeGDML 431
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 495054612 381 TINVDDDGPGVSQADREQIFRPFYR-TDEARDRESGGTGLGLAIVETAVQQHRGWVKADDSPLGGLRLTLWLPL 453
Cdd:PRK11091 432 TFEVEDSGIGIPEDELDKIFAMYYQvKDSHGGKPATGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIHA 505
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
254-453 |
5.51e-07 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 50.77 E-value: 5.51e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 254 LTRLQLGTALLRRRSGESKELERIETEAHRLDSMINDLLVMSRNQQKNALVSETMKAnqIWGEVLDNAAfeaEQMGKSFE 333
Cdd:COG4585 71 AIKLQLEAARRLLDADPEAAREELEEIRELAREALAELRRLVRGLRPPALDDLGLAA--ALEELAERLL---RAAGIRVE 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 334 VTYPPGPWLLygnPNALESALENIVR----NALRYSH-SKISVSFAVDKEGITINVDDDGPGVSQADReqifrpfyrtde 408
Cdd:COG4585 146 LDVDGDPDRL---PPEVELALYRIVQealtNALKHAGaTRVTVTLEVDDGELTLTVRDDGVGFDPEAA------------ 210
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 495054612 409 ardresGGTGLGLAIVETAVQQHRGWVKADDSPLGGLRLTLWLPL 453
Cdd:COG4585 211 ------PGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPL 249
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
341-424 |
1.60e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 46.51 E-value: 1.60e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 341 WLLYgnpnalesALENIVRNALRYSH--SKISVSFAVDKEGITINVDDDGPGVSQADREQIFRPFYrTDEARDRESGGTG 418
Cdd:cd16948 5 WLSF--------IIGQIVSNALKYSKqgGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGF-TGENGRNFQESTG 75
|
....*.
gi 495054612 419 LGLAIV 424
Cdd:cd16948 76 MGLYLV 81
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
188-237 |
6.69e-06 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 43.01 E-value: 6.69e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 495054612 188 RPARKLKNAADEVAQGNLRQHPELEaGPQEFIAAGASFNQMVTALERMMT 237
Cdd:smart00304 5 RPLRRLAEAAQRIADGDLTVRLPVD-GRDEIGELARAFNEMADRLEETIA 53
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
242-452 |
8.32e-06 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 48.13 E-value: 8.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 242 LLSDISHELRTPLTRLQLGTALLRR--RSGEskeleRIETEAHRLDSMINDLLVMSRNQQK-------NALVSETMK-AN 311
Cdd:PRK13557 177 LLQVMSGYLDVIQAALSHPDADRGRmaRSVE-----NIRAAAERAATLTQQLLAFARKQRLegrvlnlNGLVSGMGElAE 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 312 QIWGEvldnaafeaeqmGKSFEVTYPPGPWLLYGNPNALESALENIVRNA-----------LRYSHSKIS----VSFAVD 376
Cdd:PRK13557 252 RTLGD------------AVTIETDLAPDLWNCRIDPTQAEVALLNVLINArdampeggrvtIRTRNVEIEdedlAMYHGL 319
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 495054612 377 KEG--ITINVDDDGPGVSQADREQIFRPFYRTDEardrESGGTGLGLAIVETAVQQHRGWVKADDSPLGGLRLTLWLP 452
Cdd:PRK13557 320 PPGryVSIAVTDTGSGMPPEILARVMDPFFTTKE----EGKGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFP 393
|
|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
349-426 |
2.70e-05 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 42.64 E-value: 2.70e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495054612 349 ALESALENIVRNALRYSHSK-ISVSFAVDKEGITINVDDDGPGVsqaDREQIFRPfyrtdEARDRESggtGLGLAIVET 426
Cdd:cd16936 4 AVSEAVTNAVRHAYRHDGPGpVRLELDLDPDRLRVEVTDSGPGF---DPLRPADP-----DAGLREG---GRGLALIRA 71
|
|
| HAMP |
pfam00672 |
HAMP domain; |
188-234 |
6.84e-05 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 40.30 E-value: 6.84e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 495054612 188 RPARKLKNAADEVAQGNLRQHPElEAGPQEFIAAGASFNQMVTALER 234
Cdd:pfam00672 8 RPLRRLAEAARRIASGDLDVRLP-VSGRDEIGELARAFNQMAERLRE 53
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
188-335 |
6.86e-05 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 45.01 E-value: 6.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 188 RPARKLKNAADEVAQGNLRQHPELEaGPQEFIAAGASFNQMVTALERMMTTqqrlLSDISHELRTPLTRLQLGTALLRRR 267
Cdd:COG0840 208 RPLRELLEVLERIAEGDLTVRIDVD-SKDEIGQLADAFNRMIENLRELVGQ----VRESAEQVASASEELAASAEELAAG 282
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495054612 268 SGE-SKELERIETEAHRLDSMINDllVMSRNQQKNALVSETMKANQIWGEVLDNAAFEAEQMGKSFEVT 335
Cdd:COG0840 283 AEEqAASLEETAAAMEELSATVQE--VAENAQQAAELAEEASELAEEGGEVVEEAVEGIEEIRESVEET 349
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
188-232 |
7.66e-05 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 40.12 E-value: 7.66e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 495054612 188 RPARKLKNAADEVAQGNLRQHPELEaGPQEFIAAGASFNQMVTAL 232
Cdd:cd06225 2 RPLRRLTEAARRIAEGDLDVRVPVR-SKDEIGELARAFNQMAERL 45
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
357-452 |
1.28e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 40.61 E-value: 1.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 357 IVR----NALRYSH-SKISVSFAVDKEGITINVDDDGPGvsqadreqiFRPfyrtdearDRESGGTGLGLAIVETAVQQH 431
Cdd:cd16917 4 IVQealtNALKHAGaSRVRVTLSYTADELTLTVVDDGVG---------FDG--------PAPPGGGGFGLLGMRERAELL 66
|
90 100
....*....|....*....|.
gi 495054612 432 RGWVKADDSPLGGLRLTLWLP 452
Cdd:cd16917 67 GGTLTIGSRPGGGTRVTARLP 87
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
169-424 |
2.23e-04 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 43.47 E-value: 2.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 169 IVTMLVSSPLLLWLAWSLARPARKLKNAADEVAQGNLRQHPEleAGPQEFIAAGASFNQMVTALERMMTTQQRLlsdish 248
Cdd:COG2972 164 LLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLVRLEV--SGNDEIGILARSFNEMVERIKELIEEVYEL------ 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 249 ELRtpLTRLQLgtALLR---------------RRSGESKELERIETeahrldsMINDLLVMSRN--QQKNALVSetmkan 311
Cdd:COG2972 236 ELE--KKEAEL--KALQaqinphflfntlnsiRWLAELEDPEEAEE-------MLEALSKLLRYslSKGDELVT------ 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 312 qiWGEVLDNAA--FEAEQM--GKSFEVTYppgpwllygnpnALESALEN----------IVRNALRYS------HSKISV 371
Cdd:COG2972 299 --LEEELELIKsyLEIQKLrfGDRLEVEI------------EIDEELLDllipklilqpLVENAIEHGiepkegGGTIRI 364
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 495054612 372 SFAVDKEGITINVDDDGPGVSQADREQIFRPFyrtdearDRESGGTGLGLAIV 424
Cdd:COG2972 365 SIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-------SSKGEGRGIGLRNV 410
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
232-419 |
1.02e-03 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 41.46 E-value: 1.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 232 LERMMTTQQRLLSDISHELRTPLTRLQLGTALLRRRS---GESKELERIETEAHRLDSMIND--LLVMSRNQQKnALVSE 306
Cdd:PRK10618 443 YEKNQQARKAFLQNIGDELKQPLQSLAQLAAQLRQTSdeeQQQPELDQLAEQSDVLVRLVDNiqLLNMLETQDW-KPEQE 521
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 307 TMKANQIWGEVLDNAAFEAEQMGKSFEVTYPPGPWLLY-GNpnalESALENIVRNALRYS-----HSKISVSFAVDKEG- 379
Cdd:PRK10618 522 LFSLQDLIDEVLPEVLPAIKRKGLQLLIHNHLKAEQLRiGD----RDALRKILLLLLNYAitttaYGKITLEVDQDESSp 597
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 495054612 380 --ITINVDDDGPGVSQADREQIFRPFYrTDEARDRESGGTGL 419
Cdd:PRK10618 598 drLTIRILDTGAGVSIKELDNLHFPFL-NQTQGDRYGKASGL 638
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
348-457 |
1.17e-03 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 41.36 E-value: 1.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 348 NALESALENIVRNalRYSHSKISVSFAVDKEGITINVDDDGPGVSQADREQIFRPFYRTdeaRDRESGGTGLGLAIVETA 427
Cdd:PRK15053 439 NLLDNAFEASLRS--DEGNKIVELFLSDEGDDVVIEVADQGCGVPESLRDKIFEQGVST---RADEPGEHGIGLYLIASY 513
|
90 100 110
....*....|....*....|....*....|
gi 495054612 428 VQQHRGWVKADDSPLGGLRLTLWLPLYHRS 457
Cdd:PRK15053 514 VTRCGGVITLEDNDPCGTLFSIFIPKVKPN 543
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
360-453 |
3.22e-03 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 39.89 E-value: 3.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 360 NALRY-----SHSKISVSFAVDKEGITINVDDDGPGVSqadreqifrpfyrtdeARDRESGGTGLGLAIVETAVQQHRGW 434
Cdd:COG3920 410 NALKHaflsgEGGRIRVSWRREDGRLRLTVSDNGVGLP----------------EDVDPPARKGLGLRLIRALVRQLGGT 473
|
90
....*....|....*....
gi 495054612 435 VKADDSPlgGLRLTLWLPL 453
Cdd:COG3920 474 LELDRPE--GTRVRITFPL 490
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
350-430 |
9.42e-03 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 38.36 E-value: 9.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495054612 350 LESALENIVRNALRYSHSK----ISVSFAVDKEGITINVDDDGPGVSQADREQIFRPFYRTdeardrESGGTGLGLAIVE 425
Cdd:PRK11086 434 LITILGNLIENALEAVGGEeggeISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGYST------KGSNRGVGLYLVK 507
|
....*
gi 495054612 426 TAVQQ 430
Cdd:PRK11086 508 QSVEN 512
|
|
| |
