|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
18-458 |
8.72e-104 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 314.51 E-value: 8.72e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 18 LVGAFVAILNQTLLIPAIPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTILASFA 97
Cdd:cd17503 2 LLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 98 TNFPVLLAARIVQAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWIVDSFSWKFLFYIVLPIGI 177
Cdd:cd17503 82 PNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 178 IDLILAfflmknvtqqrdtridvlsvilssfgfggllygfssvgtygwtsatvlislivgavslfffilrqsnlkrPMLE 257
Cdd:cd17503 162 LALLLA----------------------------------------------------------------------PLLD 171
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 258 FGVFKFAIFSLTTFLGMLVFALLIGTETILPLYTQNVRGLSALDTGLILLPGALFMGFLSPIIGRIFDKVGGKGLALGGF 337
Cdd:cd17503 172 LRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGL 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 338 TILAVTSLPFMMLSLDSSITLITVAYTLRLIGVGMIMMPLTTAGINSLPPHLIPHGTAMNNTMRQMGGSIGTAVLVSIMS 417
Cdd:cd17503 252 LLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLT 331
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 494762741 418 SSAANAALSDPMK--------SAVHGMNTSFIVSGAIAVIGLVLSFFLK 458
Cdd:cd17503 332 NRTQFHHSRLSELlaqqvqkqALIIAFNDAFLVSAILLLVGLLLALFLR 380
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
15-415 |
7.53e-94 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 292.75 E-value: 7.53e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 15 GIFLVGAFVAILNQTLLIPAIPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTILA 94
Cdd:TIGR00711 5 IVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLC 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 95 SFATNFPVLLAARIVQAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWIVDSFSWKFLFYIVLP 174
Cdd:TIGR00711 85 GVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVP 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 175 IGIIDLILAFFLMKNVTQQRDTRIDVLSVILSSFGFGGLLYGFSSVGTYGWTSAT-VLISLIVGAVSLFFFILRQSNLKR 253
Cdd:TIGR00711 165 IGIIVVVVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSNeILILSITGLVAIIAFVVWELTDDN 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 254 PMLEFGVFKFAIFSLTTFLGMLVFALLIGTETILPLYTQNVRGLSALDTGLILLPGALFMGFLSPIIGRIFDKVGGKGLA 333
Cdd:TIGR00711 245 PLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLV 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 334 LGGFTILAVTSLPFMM-LSLDSSITLITVAYTLRLIGVGMIMMPLTTAGINSLPPHLIPHGTAMNNTMRQMGGSIGTAVL 412
Cdd:TIGR00711 325 TIGLILYAVGFYWRAFtFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTALI 404
|
...
gi 494762741 413 VSI 415
Cdd:TIGR00711 405 TTI 407
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
18-458 |
3.81e-57 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 193.54 E-value: 3.81e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 18 LVGAFVAILNQTLLIPAIPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTILASFA 97
Cdd:cd17321 2 LLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 98 TNFPVLLAARIVQAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWIVDSFSWKFLFYIVLPIGI 177
Cdd:cd17321 82 PSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 178 IDLILAfflmknvtqqrdtridvlsvilssfgfggllygfssvgtygwtsatvlislivgavslfffilrqsnlkrpmle 257
Cdd:cd17321 162 VALLLA-------------------------------------------------------------------------- 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 258 fgvfkfAIFSLTTFLGMLVFALLIGTETILPLYTQNVRGLSALDTGLILLPGALFMGFLSPIIGRIFDKVGGKGLALGGF 337
Cdd:cd17321 168 ------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGL 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 338 TILAVTSLPFMMLSLDSSITLITVAYTLRLIGVGMIMMPLTTAGINSLPPHLIPHGTAMNNTMRQMGGSIGTAVLVSIMS 417
Cdd:cd17321 242 LLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLT 321
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 494762741 418 SSAANAALSDPMK--------SAVHGMNTSFIVSGAIAVIGLVLSFFLK 458
Cdd:cd17321 322 AGLSANLGDSGVAallsaaaaAFAAGFHLAFLVAAALALLAALLALLLP 370
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
17-458 |
6.56e-43 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 154.64 E-value: 6.56e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 17 FLVGAFVAILNQTLLIPAIPHIMEEFNiDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTILASF 96
Cdd:cd17502 1 LMLALFLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 97 ATNFPVLLAARIVQAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWIVDSFSWKFLFYIVLPIG 176
Cdd:cd17502 80 APNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 177 IIDLILafflmknvtqqrdtridvLSVILSSFGFGGLLYGFssvgtygwtsatvlislivgavslfffilrqsnlkrpml 256
Cdd:cd17502 160 GLALAL------------------LRTILLSSIFGFLFGGA--------------------------------------- 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 257 efgvfkfaifslttFLGMLVFalligtetiLPLYTQNVRGLSALDTGLILLPGALFMGFLSPIIGRIFDKVGG-KGLALG 335
Cdd:cd17502 183 --------------LFGLIYY---------LPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRyKPLIVI 239
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 336 GFTILAVTSLPFMMLSLDSSITLITVAYTLRLIGVGMIMMPLTTAGINSLPPHLIPHGTAMNNTMRQMGGSIGTAVLVsi 415
Cdd:cd17502 240 GTILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAITD-- 317
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 494762741 416 msssaanaalsdpmksavhgmntSFIVSGAIAVIGLVLSFFLK 458
Cdd:cd17502 318 -----------------------VFLVALALAALAFLLSLFLP 337
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
4-407 |
4.95e-40 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 147.43 E-value: 4.95e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 4 STTSYNRSVIVGIFLVGAFVAILNQTLLIPAIPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTA 83
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 84 LSIFTAGTILASFATNFPVLLAARIVQAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWIVDSF 163
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 164 SWKFLFYIVLPIGIIDLILAFFLMKNVTQQRDTRIdvlsvilssfgfggllygfssvgtygwtsatvlislivgavslff 243
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLRLLPESRPAARARL--------------------------------------------- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 244 filrqsnlkrPMLEFGVFKFAIFSLTTFLGMLVFALLIGTETILPLYTQNVRGLSALDTGLILLPGALFMGFLSPIIGRI 323
Cdd:COG2814 197 ----------RGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRL 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 324 FDKVGGKGLALGGFTILAVtslPFMMLSLDSSITLITVAYTLRLIGVGMIMMPLTTAGINSLPPHLIPHGTAMNNTMRQM 403
Cdd:COG2814 267 ADRFGRRRLLLIGLLLLAL---GLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
|
....
gi 494762741 404 GGSI 407
Cdd:COG2814 344 GGPL 347
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
17-458 |
9.22e-38 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 141.56 E-value: 9.22e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 17 FLVGAFVAILNQTLLIPAIPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTILASF 96
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 97 ATNFPVLLAARIVQAAGAGILmPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWIVDSFSWKFLFYIVLPIG 176
Cdd:cd17504 81 APNLPVLIAGRALQGIGGAVF-PLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 177 IIDLILAFFLMKNVTQQRdtridvlsvilssfgfggllygfssvgtygwtsaTVLISLIVGavslfffilrqsnlkrpml 256
Cdd:cd17504 160 VLLAALVPLIDLRLLRRR----------------------------------NVLLANITA------------------- 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 257 efgvfkfAIFSLTTFLGMLVFALLIGTETILPLytqnvrGLSALDTGLILLPGALFMGFLSPIIGRIFDKVGGKGLALGG 336
Cdd:cd17504 187 -------LLAGFGMFMVFQLLPQLLQLPTPTGF------GLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIG 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 337 FTILAVTSLpfMMLSLDSSITLITVAYTLRLIGVGMIMMPLTTAGINSLPPHLIPHGTAMNNTMRQMGGSIGTAVLVSIM 416
Cdd:cd17504 254 LVISAVGLL--LLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAIL 331
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 494762741 417 SSSAANAALSDPmkSAVHGMNTSFIVSGAIAVIGLVLSFFLK 458
Cdd:cd17504 332 TTYTVSITSGGV--PTEGAYVLAFLIGAALALAALLLSLLIP 371
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
17-458 |
2.82e-30 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 121.14 E-value: 2.82e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 17 FLVGAFVAILNQTLLIPAIPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTILASF 96
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 97 ATNFPVLLAARIVQAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWIVDSFSWKFLFYIVLPIG 176
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 177 IIDLILAFFLMKNVTQQRDTRIDVLSVILSSfgfggllygfssvgtygwtsatvlislivgavslFFFILRQSNLkrpml 256
Cdd:cd17325 161 LLALVLALLLLPEPRPPPNKRAVSAARLRSG----------------------------------LRLLLRDRRL----- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 257 efgvfkfAIFSLTTFLGMLVFALLigtETILPLYTQNVRGLSALDTGLILLPGALFMGFLSPIIGRIFDKVGGKGLALGG 336
Cdd:cd17325 202 -------LALFLAIFVLAFAFGAL---EPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIG 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 337 FTILAVTslpFMMLSLDSSITLITVAYTLRLIGVGMIMMPLTTAGINSLPPHLIPHGTAMNNTMRQMGGSIGTAVLVSIM 416
Cdd:cd17325 272 LLLSAVA---LLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLY 348
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 494762741 417 sssaanaalsdpmksAVHGMNTSFIVSGAIAVIGLVLSFFLK 458
Cdd:cd17325 349 ---------------DAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
21-457 |
1.39e-28 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 116.13 E-value: 1.39e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 21 AFVAILNQTLLIPAIPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTILASFATNF 100
Cdd:cd17474 8 TLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 101 PVLLAARIVQAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWIVDsFSWKFLFYIVLPIGIIDL 180
Cdd:cd17474 88 ALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLAALIPVAF 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 181 ILAFFLMKN----VTQQRDTRIDVLSVILSSFGFGGLLygfssvgtygwtsatvlislivgavslfffilrqsnlkrpml 256
Cdd:cd17474 167 LAILFLLPEpkekAKSSSATKLRDLKKALRGRGLLTFL------------------------------------------ 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 257 efgvfkfaifslttFLGMLVFALLIGTETILPLYTQNVRGLSALDTGLILLPGALFMGFLSPIIGRIFDK-VGGKGLALG 335
Cdd:cd17474 205 --------------VSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVI 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 336 GFTILAVTslpFMMLSLDSSITLITVAYTLRLIGVGMIMMPLTTAGINSLPPHLIPHGTAMNNTMRQMGGSIGtAVLVSI 415
Cdd:cd17474 271 GLLLYALS---LLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVG-PLLFGL 346
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 494762741 416 MsssaanaalsdpmkSAVHGMNTSFIVSGAIAVIGLVLSFFL 457
Cdd:cd17474 347 L--------------LEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
16-415 |
3.74e-28 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 116.96 E-value: 3.74e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 16 IFLVGAFVAILNQTLLIPAIPHIMEEFNiDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTILAS 95
Cdd:cd06179 2 ALCLAYFAQLFGVTLPAAVLPFIVADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 96 FATNFPVLLAARIVQAAGAGILmPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWIV--DSFSWKFLFYIVL 173
Cdd:cd06179 81 TAKSVNMLIGGQALIGIGAGTQ-GLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVeaNAAGWRWIFYINA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 174 PIGIIDLILAFF---------LMKNVTQQRDTRIDVLSVILSSFGFGGLLYGFSSVGT-YGWTSATVLISLIVGAVSLFF 243
Cdd:cd06179 160 IFNALALILLFFfyhppprpqLHGSSTRQKLKRLDWVGLFLLIAGLVLFLLGLSWGGNpYPWSSAHVIAPLVIGGVLLIA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 244 FIL-----RQSNLKRPMLEFGVFKFA-IFSLTTFLGMLVFALLIgtetILPLYTQNVRGLSALDTGLILLPGALFMGFLS 317
Cdd:cd06179 240 FGLyewkgTKDGLLPPRLLFRGRNFAlILIVAFVEGMIFYSLNI----FWPQQISLLFTTDPLKAGLYQLPFGLGTLFGA 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 318 PIIGRIFDKVGGKGLALGGFTILAVTSLPFMMLSLDSSITLITVAYTLRLIGVGMIMMPLTTAGINSLPPHLIPHGTAMN 397
Cdd:cd06179 316 ILAGLLLTKIKHIKWQLVAGFVLFTAFLALLALITPDNKALAIAFSVLAGIGIGGPLVLAIVIVQLSVPPEDIGTASGLL 395
|
410
....*....|....*...
gi 494762741 398 NTMRQMGGSIGTAVLVSI 415
Cdd:cd06179 396 GSARALGGAVGTAIFTSI 413
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
17-409 |
2.48e-27 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 112.13 E-value: 2.48e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 17 FLVGAFVAILNQTLLIPAIP-HIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTILAS 95
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 96 FATNFPVLLAARIVQAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWIVDSFSWKFLFYIVLPI 175
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 176 GIIDLILAFFLMKNVTQQRDTRidvlsvilssfgfggllygfssvgtygwtsatvlislivgavslfffilRQSNLKRPM 255
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKP-------------------------------------------------AEEARLSLI 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 256 LEFGVFKFAIFSLTTFLGMLVFALLIGTETILPLYtQNVRGLSALDTGLILLPGALFMGFLSPIIGRIFDKVGGKGLALG 335
Cdd:pfam07690 192 VAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLL 270
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 494762741 336 GFTILAVTSLPFMMLSLDSSITLITVAYTLRLIGVGMIMMPLTTAGINSLPPHLIPHGTAMNNTMRQMGGSIGT 409
Cdd:pfam07690 271 ALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
16-411 |
1.74e-26 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 111.75 E-value: 1.74e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 16 IFLVGAFVAILNQTLLIPAIPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTILAS 95
Cdd:PRK10504 14 IVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 96 FATNFPVLLAARIVQAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWIVDSFSWKFLFYIVLPI 175
Cdd:PRK10504 94 LSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPV 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 176 GIIDLILAFFLMKNVTQQrDTRIDVLSVILSSFGFGGLLYGFSSVGTYGWTSATVLISLIVGAVSLFFFILRQSNLKRPM 255
Cdd:PRK10504 174 GIIGAIATLMLMPNYTMQ-TRRFDLSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLVAVGVVALLLYLLHARNNNRAL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 256 LEFGVFKFAIFSLTTF--------LGMLVFalligtetILPLYTQNVRGLSALDTGLILLPGALFMGFLSPIIGRIFDKV 327
Cdd:PRK10504 253 FSLKLFRTRTFSLGLAgsfagrigSGMLPF--------MTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRF 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 328 GGKGLALGGFTILAVTSLPFMMLSLDSSITLITVAYTLRLIGVGMIMMPLTTAGINSLPPHLIPHGTAMNNTMRQMGGSI 407
Cdd:PRK10504 325 GYRRVLVATTLGLALVSLLFMLVALLGWYYLLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLSMSI 404
|
....
gi 494762741 408 GTAV 411
Cdd:PRK10504 405 GVTI 408
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
9-289 |
4.97e-25 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 104.51 E-value: 4.97e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 9 NRSVIVGIFLVGAFVAILNQTLLIPAIPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFT 88
Cdd:COG0477 11 RRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 89 AGTILASFATNFPVLLAARIVQAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWIVDSFSWKFL 168
Cdd:COG0477 91 LASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWI 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 169 FYIVLPIGIIDLILAFFLMKNVTQQRDTRIDVLSVILSSFGFGGLLYGFSSVGTYGWTSATVLISLIVGAVSLFFFILRQ 248
Cdd:COG0477 171 FLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLAL 250
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 494762741 249 SNLKRPMLEFGVFKFAIFSLTTFLGMLVFALLIGTETILPL 289
Cdd:COG0477 251 LLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLL 291
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
3-462 |
5.83e-25 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 105.72 E-value: 5.83e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 3 QSTTSYNRSVIVGIFLVGAFVAILNQTLLIPAIPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLT 82
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 83 ALSIFTAGTILASFATNFPVLLAARIVQAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWIVDS 162
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 163 FSWKFLFYIVLPIGIIDLILAFFLMknvtqqrdtridvlsvILSSFGFGGLLYGFSsvgtygwtsatvlislivgavslf 242
Cdd:COG2271 161 FGWRAAFLILGLPGLLLALLRFWLL----------------ALAYFLVYFALYGFL------------------------ 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 243 ffilrqsnlkrpmlefgvfkfaifslttflgmlvfalligteTILPLYTQNVRGLSALDTGLILLPGALFMGFLSPIIGR 322
Cdd:COG2271 201 ------------------------------------------TWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGW 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 323 IFDKVGGKGLALGGFTiLAVTSLPFMMLSLDSSITLITVAYTLRLIGVGMIMMPLTTAGINSLPPHLIPHGTAMNNTMRQ 402
Cdd:COG2271 239 LSDRLGRRRKLVLAIG-LLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGF 317
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 403 MGGSIGTAVLVSIMsssaanaalsdpmksAVHGMNTSFIVSGAIAVIGLVLSFFLKEKRK 462
Cdd:COG2271 318 LGGALGPLLVGYLL---------------DATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
16-412 |
2.21e-24 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 104.19 E-value: 2.21e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 16 IFLVGAFVAI--LNQTLLIPAIPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTIL 93
Cdd:cd17320 1 LLLLALLVALgpLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 94 ASFATNFPVLLAARIVQAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWIVDSFSWKFLFYIVL 173
Cdd:cd17320 81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 174 PIGIIDLILAFFLMKNvTQQRDTRIDVLSVILSSFGfggllygfssvgtygwtsatvlislivgavslfffilrqsnlkr 253
Cdd:cd17320 161 LLGLLLLLLVLLFLPE-TLPEEKRKPLLSSLLRAYK-------------------------------------------- 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 254 pmlefGVFKFAIFSLTTFLGMLVFALLIGTETILPLYTQNVRGLSALDTGLILLPGALFMGFLSPIIGRIFDKVGGKGLA 333
Cdd:cd17320 196 -----RVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLL 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 334 LGGFTILAVTSLPFMMLSLDSSITLITVAYTLRLIGVGM-IMMPLTTAGINSLPPHLIPHGTAMNNTMRQMGGSIGTAVL 412
Cdd:cd17320 271 RLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFgLIFPNATSLALEPFPHVAGTASALLGFLQFLIGALAGALV 350
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
14-411 |
3.16e-24 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 103.78 E-value: 3.16e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 14 VGIFLVGAFVAILNQTLLIPAIPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTIL 93
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 94 ASFATNFPVLLAARIVQAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWIVDSFSWKFLFYIVL 173
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 174 PIGIIDLILAFFLMKNVTQQRDTRIDVLSVILSSFGFGGLLYGFssvgtygwtsatVLISLIVGAVSLFFfilrqsnlkr 253
Cdd:cd17324 161 VLALLAALLLWRLLPSLPPKKPGSLGLLSSLLLLLRNPRLRLAY------------LITFLLFGGFFALY---------- 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 254 pmlefgvfkfaifslttflgmlvfalligteTILPLYTQNVRGLSALDTGLILLPGALFMGFLSPIIGRIFDKVGGKGLA 333
Cdd:cd17324 219 -------------------------------TYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALL 267
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 494762741 334 LGGFTILAVTSLPFMMLSLDSSITLITVaytlrLIGVGM-IMMPLTTAGINSLPPHLIPHGTAMNNTMRQMGGSIGTAV 411
Cdd:cd17324 268 IALLLLAAALLLLTLLGPSPLLLLVGLV-----LWGLGFfAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAAL 341
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
9-465 |
1.42e-22 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 99.18 E-value: 1.42e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 9 NRSVIVGIFLVGAFVAILNQTLLIPAIPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFT 88
Cdd:COG2223 2 GRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 89 AGTILASFATNFPVLLAARIVQAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWIVDSFSWKFL 168
Cdd:COG2223 82 IGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 169 FYIVLPIGIIDLILAFFLMKNVTQQRDTridvlsviLSSFGFGGLLYGFSSVGTYgwtsatvlislivgAVSLFFFIlrq 248
Cdd:COG2223 162 FLILGILLLVVAVLAWLFLRDPPAGAAA--------AAKASLRDQLEALRDPRFW--------------LLSLLYFG--- 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 249 snlkrpmlefgvfkfaifsltTFLGMLVFAlligteTILPLYTQNVRGLSALDTGLILLPGALFMGFLSPIIGRIFDKVG 328
Cdd:COG2223 217 ---------------------TFGSFIGFS------SWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIG 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 329 GKGLALGGFTILAVTSLPFMMLSLdssitlitvayTLRLIGVGMIMMPLTTAGINSLPPHLIP-----HGTAMNNTMRQM 403
Cdd:COG2223 270 GRRVLLIVFALMALGLLLLALALG-----------SLWLFLVLFLLLGLALGGGNGAVFALVPdifptKNAGAVYGLVGA 338
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 494762741 404 GGSIGTAVLVSIMSSsaanaalsdpMKSAVHGMNTSFIVSGAIAVIGLVLSFFLKEKRKNKV 465
Cdd:COG2223 339 AGGLGGFLGPLLFGA----------LLDATGSYTAAFLVFAVLALVALVLTLLLYRRPRRAA 390
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
12-411 |
5.28e-22 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 98.65 E-value: 5.28e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 12 VIVGIFLVGAFVAIlNQTLLIPAIPHIMEEFNIDVSKGQWLTTAFMLT-NGILIPITAfLIEKFSSRSLVLTALSIFTAG 90
Cdd:PRK14995 7 TLVIIVLVYIPVAI-DATVLHVAAPTLSMTLGASGNELLWIIDIYSLVmAGMVLPMGA-LGDRIGFKRLLMLGGTLFGLA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 91 TILASFATNFPVLLAARIVQAAGAGILMPLMQTIFLTIFPKEK-RGQAMGMVGLVISFAPALGPTLGGWIVDSFSWKFLF 169
Cdd:PRK14995 85 SLAAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATFTEEKqRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVF 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 170 YIVLPIGIIDLILAFFLMKNVTQQRDTRID-------VLSVILSSFGFGGLLYGFSSVGTygwtsatVLISLIVGAVSLF 242
Cdd:PRK14995 165 LINVPIVLVVMGLTARYVPRQAGRRDQPLNlghalmlIVAILLLVYSAKTALKGFLSLWV-------TSLTLLTGALLLG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 243 FFILRQSNLKRPMLEFGVFKFAIFSLTTFLGMLVFALLIGTETILPLYTQNVRGLSALDTGLILLPGALFMGFLSPIIGR 322
Cdd:PRK14995 238 LFIRTQLAASRPMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGI 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 323 IFDKVGGKGLALGGFTILAVTSLPFMMLSLDSSITLITVAYTLRLIGVGMIMMPLTTAGINSLPPHLIPHGTAMNNTMRQ 402
Cdd:PRK14995 318 LVSRLGLRLVATGGMALSALSFYGLAMTDFSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPPEKAAAAGAIETMAYE 397
|
....*....
gi 494762741 403 MGGSIGTAV 411
Cdd:PRK14995 398 LGAGLGIAI 406
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
10-457 |
3.35e-20 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 91.86 E-value: 3.35e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 10 RSVIVGIFLVGAFVAILNQTLLIPAIPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTA 89
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 90 GTILASFATNFPVLLAARIVQAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWIVDSFSWKFLF 169
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 170 YIVLPIGIIDLILAFFLMKNvtqqrdtridVLSVILSSFGFGGLLYGFSsvgtygwtsatvlislivgavslfffilrqs 249
Cdd:cd17319 161 IIEGLLGLLLAVLWWFYLRQ----------VWGLALGYFGINYALYGLL------------------------------- 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 250 nlkrpmlefgvfkfaifslttflgmlvfalligteTILPLYTQNVRGLSALDTGLILLPGALFMGFLSPIIGRIFDKVGG 329
Cdd:cd17319 200 -----------------------------------TWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLR 244
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 330 KGLALGGFTILAVTSLPFMMLSLDSSITLITVAYTLRLIGVGMIMMPLTTAGINSLPPHLIPHGTAMNNTMRQMGGSIGT 409
Cdd:cd17319 245 GARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAP 324
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 494762741 410 AVLVSImsssaanaalsdpmKSAVHGMNTSFIVSGAIAVIGLVLSFFL 457
Cdd:cd17319 325 LLIGYL--------------VDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
22-253 |
1.23e-18 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 87.25 E-value: 1.23e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 22 FVAILNQTLLIPAIPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTILASFATNFP 101
Cdd:cd17323 9 FVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 102 VLLAARIVQAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWIVDSFSWKFLFYIVLPIGIIDLI 181
Cdd:cd17323 89 MLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLI 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 182 LAFFLMKNVtqqrdtridVLSVILSSFGFgGLLYGFSS------VGTYGWTSATV---LISLIVGAVSLFFFILRQSNLK 252
Cdd:cd17323 169 LIFLFLPIV---------LLLGLYVGLVY-AILYLFLTafpyvfGEVYGFSPGEVglmYLPIGIGALIGSIIGGRLSDYY 238
|
.
gi 494762741 253 R 253
Cdd:cd17323 239 Y 239
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
14-280 |
7.12e-18 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 85.37 E-value: 7.12e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 14 VGIFLVGAFVAILNQTLLIPAIPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTIL 93
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 94 ASFATNFPVLLAARIVQAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWIVDSF-SWKFLFYIV 172
Cdd:cd17328 81 SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 173 LPIGIIDLILAFFLMKNvtQQRDTRIDVLSVILSSFGFGGLLYGFSSVGTYGWTS-ATVLISLIVGAVSLFF--FILRQS 249
Cdd:cd17328 161 GVLGVLLAILLLLFVRE--PPRGAAEGGVMAKSTATSFLADLKALAKNPSFILSTlGFTAVSFVTGALAFWAptFFLRAF 238
|
250 260 270
....*....|....*....|....*....|..
gi 494762741 250 NLKRPMLEFGVFKF-AIFSLTTFLGMLVFALL 280
Cdd:cd17328 239 GVGDLSSADVGLIFgAITCIAGVLGVLLGGIL 270
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
26-415 |
1.80e-17 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 83.97 E-value: 1.80e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 26 LNQTLLIPAIPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTILASFATNFPVLLA 105
Cdd:TIGR00710 19 LGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLV 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 106 ARIVQAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWIVDSFSWKFLFYIVLPIGIIDLILAFF 185
Cdd:TIGR00710 99 LRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFF 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 186 LMKNVTQQRDtridvlsvilssfgfggllygFSSVGTYGWTsatvlislivgavslFFFILRQSNLKRPMLEFGvFKFAI 265
Cdd:TIGR00710 179 ILPETLPYEA---------------------RIQISTYFET---------------FLLLLKSKMFWGYALIYG-ASFGG 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 266 FslttflgmlvFALLIGTETILplytQNVRGLSALDTGLILLPGALFMGFLSPIIGRIFDKVGGKGLALGGFTILAVTS- 344
Cdd:TIGR00710 222 F----------FAFFSGAPFVY----IDIMGVSPSVFGLLFALNIIAMIFGGFLNGRFIKKWGAKSLLRMGLILFAVSAv 287
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 494762741 345 -LPFMMLSLDSSITLITVAYTLRLIGVGMImMPLTTAGINSLPPHLIPHGTAMNNTMRQMGGSIGTAVLVSI 415
Cdd:TIGR00710 288 lLEITAILGLGSWAMIIGPMMFVGIGNSMI-SSIAMAYALEDFPHVAGTASALFGTLRLVLGAIVGYLVSLI 358
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
30-412 |
2.87e-16 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 79.95 E-value: 2.87e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 30 LLIPAIPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTILASFATNFPVLLAARIV 109
Cdd:cd17489 14 LLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLI 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 110 QAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWIVDSFSWKFLFYIVLPIGIIDLILAFFLmkn 189
Cdd:cd17489 94 HGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLV--- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 190 vtqqrdtridvlsvilssfgfggllygfssvgtygwTSATVLISLIVGAVSLFFFILRQSNLKRPMLEFGVFKFAIFSLT 269
Cdd:cd17489 171 ------------------------------------KDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAIS 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 270 TFlgmlvfalligtetiLPLYTQNvRGLSalDTGLILLPGALFMGFLSPIIGRIFDKVGGKGLALGGFTILAVTslpFMM 349
Cdd:cd17489 215 TF---------------LPLYAAE-RGIS--NAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALG---LLL 273
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 494762741 350 LSLDSSITLITVAYTLRLIGVGMIMMPLTTAGINSLPPHLIPHGTAMNNTMRQMGGSIGTAVL 412
Cdd:cd17489 274 LSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLL 336
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
65-188 |
5.15e-16 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 74.61 E-value: 5.15e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 65 PITAFLIEKFSSRSLVLTALSIFTAGTILASFATNFPVLLAARIVQAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLV 144
Cdd:TIGR00880 16 PLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVALGLMSAG 95
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 494762741 145 ISFAPALGPTLGGWIVDSFSWKFLFYIVLPIGIIDLILAFFLMK 188
Cdd:TIGR00880 96 IALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
12-350 |
2.29e-15 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 77.61 E-value: 2.29e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 12 VIVGIFLVgAFVAILNQTLLIPAIPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGT 91
Cdd:COG2807 19 LLLAIVLV-ALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 92 ILASFATNFPVLLAARIVQAAGAGILMPLMQTIFLTIFPKeKRGQAMGMVGLVISFAPALGPTLGGWIVDSFSWKFLFYI 171
Cdd:COG2807 98 LLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPD-RVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAV 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 172 VLPIGIIDLILAFFLMKNVTQQR---DTRIDVLSVILSS--------FGFGGLLY--------------GFSSVGTyGWT 226
Cdd:COG2807 177 WALLALLALLLWLPLLRRRPAAAaaaPAAASLRSLWRSPlawlltlfFGLQSLLYyavvawlppilrdaGLSAATA-GLL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 227 SATVLISLIVGAVSLFFFILRQSNLKRPMLEFGVFK---FAIFSLTTFLGMLVFALLIG---------TETILPLYTQNV 294
Cdd:COG2807 256 LSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGlagLLGLLLAPGSLPWLWAVLLGlgqgglfplALTLIGLRARTP 335
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 494762741 295 RGLSALdTGLILLPGALFMGFLSPIIGRIFDKVGGKGLALGGFTILAVTSLPFMML 350
Cdd:COG2807 336 AEAAAL-SGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLL 390
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
16-188 |
2.77e-15 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 77.25 E-value: 2.77e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 16 IFLVGAFVAI--LNQTLLIPAIPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTIL 93
Cdd:PRK11652 10 LFMLVLLVAVgqMAQTIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 94 ASFATNFPVLLAARIVQAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWIVDSFSWKFLFYIVL 173
Cdd:PRK11652 90 ALFAHSLTVLIAASAIQGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLL 169
|
170
....*....|....*
gi 494762741 174 PIGIIDLILAFFLMK 188
Cdd:PRK11652 170 LLGAGVTFSMARWMP 184
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
18-457 |
1.31e-14 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 75.30 E-value: 1.31e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 18 LVGAFVAILNQTLLIPAIPHIMEEFNIDVSKG-QWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTILASF 96
Cdd:cd17473 5 LLASTLTVMAGAAIAPALPAIAQHFVPNSELLvPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 97 ATNFPVLLAARIVQAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWIVDsFSWKFLFYIVLpIG 176
Cdd:cd17473 85 LDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYL-LA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 177 IIDLILAFFLMKNVTQQRDTRIDVLSVILSSFgfggllygfssvgtygwtsatvlislIVGAVSLFFFIlrqsnlkrpml 256
Cdd:cd17473 163 LPVLILVLLFLPEPARKSKSAASPGAATAAAL--------------------------PWKRVLPIYFL----------- 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 257 efgvfkfaifsltTFLGMLVFALLIgteTILPLYTQNVRGLSALDTGLILLPGALFMGFLSPIIGRIFDKVGGKGLALGG 336
Cdd:cd17473 206 -------------AFLAMLLFYVIP---IQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIG 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 337 FTILAVTslpFMMLSLDSSITLITVAYTLRLIGVGMIMMPLTTAGINSLPPHLIPHGTAMNNTMRQMGGSIGTAVLvsim 416
Cdd:cd17473 270 FALMALG---FLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVL---- 342
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 494762741 417 sssaanaalsDPMKSAVHGMNTSFIVSGAIAVIGLVLSFFL 457
Cdd:cd17473 343 ----------GPLVNLTGGLSGAFLILGVLALVLAIVLLLL 373
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
1-217 |
6.92e-13 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 69.88 E-value: 6.92e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 1 MNQSTTSYNRSVIVGIFLVGAFVAILNQTLlipaIPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLV 80
Cdd:COG0738 1 MSKKNYRRALIAIYLLFFLWGFATALWGPL----IPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 81 LTALSIFTAGTILASFATNFPVLLAARIVQAAGAGILMPLMQTIFLTIFPkEKRGQAMGMVGLVISFAPALGPTLGGWIV 160
Cdd:COG0738 77 LLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGP-ETAASRLNLLHAFFSLGALLGPLLGGLLI 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 494762741 161 D---SFSWKFLFYIV-LPIGIIDLILAFFLMKNVTQQRDTRIDVLSVILSSFGFGGLLYGF 217
Cdd:COG0738 156 LlglSLSWHLPYLILaVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGG 216
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
1-188 |
8.33e-12 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 66.61 E-value: 8.33e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 1 MNQSTTSYNRSVIVGIFLVgAFVAILNQTLLIPAIPHIMEEFNIDVSKGQWLTTAF---MLTNGILIPITAfliEKFSSR 77
Cdd:TIGR00895 7 RKQPLSRYQWRAIILSFLI-MLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGligMAFGALFFGPLA---DRIGRR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 78 SLVLTALSIFTAGTILASFATNFPVLLAARIVQAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGG 157
Cdd:TIGR00895 83 RVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAG 162
|
170 180 190
....*....|....*....|....*....|.
gi 494762741 158 WIVDSFSWKFLFYIVlpiGIIDLILAFFLMK 188
Cdd:TIGR00895 163 WLIPVFGWRSLFYVG---GIAPLLLLLLLMR 190
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
22-412 |
5.94e-11 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 63.90 E-value: 5.94e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 22 FVAILNQTLLIPAIPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTILASFATNFP 101
Cdd:TIGR00893 4 VINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGAYV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 102 VLLAARIVQAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWIVDSFSWKFLFYIVLPIGIIDLI 181
Cdd:TIGR00893 84 SLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLGIIWGV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 182 LAFFLMKNVTQQRDTRIDVLSVILSsfgfGGLLYGFSSVGTYGWTSATVLislivgavslffFILRQsnlkRPMLEFGVF 261
Cdd:TIGR00893 164 LWLKFIPDPPQKAKWLTEEEKYIVV----GGLLAEQQGKGPSTPKKYQIK------------ELLKD----RRVWGLALG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 262 KFAIFSLTTFLGmlvfalligteTILPLYTQNVRGLSALDTGLILLPGALFmGFLS-PIIGRIFDKVGGKGLALGGFTIL 340
Cdd:TIGR00893 224 QFLVNIGLGFFL-----------TWFPTYLVQERGLSILEAGFMASLPGIV-GFIGmILGGRLSDLLLRRGKSLVFARKT 291
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 494762741 341 AVTSLPFMMLSLDSSITLITVAYTLRLIGVGMIMMPLTTAGI----NSLPPHLIPHGTAMNNTMRQMGGSIGTAVL 412
Cdd:TIGR00893 292 AIIAGLVLSLLMFATNYVNIPYAALALVALGFFGLGAGAIGWalisDNAPGNIAGLTGGLINSLGNLGGIVGPIVI 367
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
17-281 |
1.18e-10 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 63.21 E-value: 1.18e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 17 FLVGAFVAILNQTLLIPAIPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTILASF 96
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 97 ATNFPVLLAARIVQAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWIVD--SFSWKFLFYIVLP 174
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 175 IGIIDLILAFFLMKnvtQQRDTRIDVLSVILSSFGFGGLLYGFSSVGTYGWTSATVLISLIVGAVSLFFFILRQSNLKRP 254
Cdd:cd06174 161 LALLAAILLLLVVP---DPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLS 237
|
250 260
....*....|....*....|....*..
gi 494762741 255 MLEFGVFkFAIFSLTTFLGMLVFALLI 281
Cdd:cd06174 238 VAVAGLL-LSLFGLAGALGSLLLGLLS 263
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
49-187 |
8.06e-10 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 60.32 E-value: 8.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 49 GQWLTTAFMLTNGILI----PITAFLIEKFSSRSLVLTALSIFTAGTILASFATNFPVLLAARIVQAAGAGILMPLMQTI 124
Cdd:cd17329 234 GESLLGLLLALNALLIvllqFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTL 313
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 494762741 125 FLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWIVDSFSWKFLFYIVLPIGIIDLILAFFLM 187
Cdd:cd17329 314 VAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
70-225 |
8.53e-10 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 60.29 E-value: 8.53e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 70 LIEKFSSRSLVLTALSIFTAGTILASFATNFPVLLAARIVQAAGAGILMPLMQTIFLTIFPKEKRGQA----MGMVGLvi 145
Cdd:PRK11043 64 LSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVGVCSAAVIWQALVIDRYPAQKANRVfatiMPLVAL-- 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 146 sfAPALGPTLGGWIVDSFSWKFLFYIVLPIGIIDLILAFFLMKNVTQQRDT--RIDVLSvILSSFGFGG--LLYGFSSVG 221
Cdd:PRK11043 142 --SPALAPLLGAWLLNHFGWQAIFATLFAITLLLILPTLRLKPSKKARKQSqdALTFKQ-LLKSKTYLGnvLIFAACSAA 218
|
....
gi 494762741 222 TYGW 225
Cdd:PRK11043 219 FFAW 222
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
18-278 |
2.48e-09 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 58.74 E-value: 2.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 18 LVGAFVAILNQTLLIPAIPHIMEEFN---IDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTILA 94
Cdd:cd17330 2 FLVVFLDALGFGIVFPVLPFYVREFNklgASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 95 SFATNFPVLLAARIVQAAGAGILmPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWIVDSFSWKFLFYIVLP 174
Cdd:cd17330 82 GLSRNLWLLFLARFLDGLTGGNV-SVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 175 IGIIDLILAFFLMKNVtqqrdtRIDVLSVILSSFGFGGLLYGFS--SVGTYGWTSATV-LISLIVGAVSLFFFILRQSNL 251
Cdd:cd17330 161 LALLNLVLVLFFLPPL------RRLLLVYFLIALAFAGLESVFSlfLKDRFGFSPSQIgLLLALVGIAGILAQLLLIPRL 234
|
250 260
....*....|....*....|....*..
gi 494762741 252 KRPMLEFGVFKFAIFSLTTFLGMLVFA 278
Cdd:cd17330 235 AKRLGERKLLRLGLLLAIIGLLLLPFA 261
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
18-224 |
5.84e-09 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 57.57 E-value: 5.84e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 18 LVGAFVAILNQTLLIPAIPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTILASFA 97
Cdd:cd17477 2 LLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 98 TNFPVLLAARIVQAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWiVDSFSWKFLFYIVLPIGI 177
Cdd:cd17477 82 DSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLAL-VGTAGALPFLIAAVLLLL 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 494762741 178 IDLILAFFLMKNVTQQRDTRIDVLSVILSSFG--FGGLLYGFSSVGTYG 224
Cdd:cd17477 161 ALVPLLLTRRAAPEIEEAESISLRRLLRIAPLalLGAFVAGFLEGAFYS 209
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
35-187 |
6.57e-09 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 57.62 E-value: 6.57e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 35 IPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIE-KFSSRSLVLTALSIFTAGTILASFATNFPVLLAARIVQAAG 113
Cdd:cd17490 218 TPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFYkKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFG 297
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 494762741 114 AGILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWIVDSFSWKFLFYIVLPIGIIDLILAFFLM 187
Cdd:cd17490 298 TGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSLAYY 371
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
12-187 |
8.65e-09 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 57.28 E-value: 8.65e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 12 VIVGIFLVGAFVAILNQTLLIPAIPhIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGT 91
Cdd:cd17355 4 VLAVTFLILILSWGIRYYFGVFIIP-IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 92 ILASFATNFPVL-LAARIVQAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWIVDSFSWKFLFY 170
Cdd:cd17355 83 VLLALATSLWQLyLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALL 162
|
170
....*....|....*..
gi 494762741 171 IVLPIGIIDLILAFFLM 187
Cdd:cd17355 163 VLALLALLVLVPVLLLL 179
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
32-221 |
1.22e-08 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 56.85 E-value: 1.22e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 32 IPAIPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTILASFATNFPVLLAARIVQ- 110
Cdd:PRK11102 11 LPALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHg 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 111 ---AAGAGILMPLMQTIFltifPKEKRGQAMGMVGLVISFAPALGPTLGGWIVDSFSWKFLFYIVLPIGIIDLILAFFLM 187
Cdd:PRK11102 91 laaAAASVVINALMRDMF----PKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFI 166
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 494762741 188 KNvTQQRDTRI------------------DVLSVILSS-FGFGGlLYGFSSVG 221
Cdd:PRK11102 167 PE-TLPKERRQpfhlrttirnfaslfrhkRVLGYMLASgFSFAG-MFSFLTAG 217
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
73-190 |
1.82e-08 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 56.07 E-value: 1.82e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 73 KFSSRSLVLTALSIFTAGTILASFATNFPVLLAARIVQAAGA--GILMPLMQTifLTifPKEKRGQAMGMVGLVISFAPA 150
Cdd:cd17472 58 RIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGAisSVVMALLAD--LT--REENRTKAMALIGASIGIAFA 133
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 494762741 151 LGPTLGGWIVDSFSWKFLFYIVLPIGIIDLILAFFLMKNV 190
Cdd:cd17472 134 ISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDP 173
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
34-298 |
2.85e-08 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 56.21 E-value: 2.85e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 34 AIPHIMEEfnIDVSKGQWL-TTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTILASFATNFPVLLAARIVQAA 112
Cdd:pfam06609 66 ALPNILQD--IGQSENQGLfSTLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVGCTANKFNTLLAAMTLLGV 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 113 GAGilmPLMQTiflTIFPKEKRGQAMGMVGLVISFAP-----ALGPTLGGWIVDSFSWKFLFYIVLPIGIIDLILAFF-- 185
Cdd:pfam06609 144 AAG---PAGAS---PLFIGELMSNKTKFLGLLIVSAPtiamnGAGPYFGQRLAIQGNWRWIFYIYIIMSAIAVLLIIIwy 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 186 -------LMKNVTQQRD--TRIDVLSVILSSFGFGGLLYGFSSVGTYG--WTSATVLISLIVGAVSLFFFILRQSNLK-- 252
Cdd:pfam06609 218 hppsfaqLHGKKARKRDelAKLDWIGIFLVIAGTSLFLLGVSWGGKPNnpWNSAKIIGLISSGAGSLVIFALYEVFGKpe 297
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 494762741 253 RPMLEFGVFK-----FAIFSLTTFLGMLVFALLIgtetILPLYTQNVRGLS 298
Cdd:pfam06609 298 QPIIPPALFKdtrgfVCILIISSIMGAMHLCLTI----IYPQQVINIFGSS 344
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
26-188 |
7.28e-08 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 54.10 E-value: 7.28e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 26 LNQTLLIPAIPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTILASFATNFPVLLA 105
Cdd:cd17478 10 FYQGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 106 ARIVQAAGAGILMPLMQTIfLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWIVDSFSWKFLFYIVLPIGIIDLILAFF 185
Cdd:cd17478 90 LVALAGIGSAAFHPEGARL-ASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLR 168
|
...
gi 494762741 186 LMK 188
Cdd:cd17478 169 LRP 171
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
22-186 |
1.05e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 53.86 E-value: 1.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 22 FVAILNQTLLIPAIPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTILASFATNFP 101
Cdd:cd17333 6 FSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIY 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 102 VLLAARIVQAAGAGILMPLMQTIFLTIFPkEKRGQAMGMVGLVISFAPALGPTLGGWIVD-SFSWKFLFYIVLPIGIIDL 180
Cdd:cd17333 86 LFVVLMFLAGLGAGILDTGANTFVGALFE-ESSATRLNVLHGFFGLGALIGPLIATSLLTsELSWSWAYLIIGLIYLLLA 164
|
....*.
gi 494762741 181 ILAFFL 186
Cdd:cd17333 165 ILILLT 170
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
37-329 |
1.20e-07 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 53.71 E-value: 1.20e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 37 HIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTILASFATNFPVL-LAARIVQAAGAG 115
Cdd:cd17352 28 ELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLyLTYGVLGGLGLG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 116 ILMPLMQTIFLTIFPKeKRGQAMGMVGLVISFAPALGPTLGGWIVDSFSWKflfYIVLPIGIIDLILAFF-LMKNVTQQR 194
Cdd:cd17352 108 LIYSPAIVIVGQYFEK-KRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWR---GALLILGGLCLNLCVCgLLLRLLKDP 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 195 DTRIDVLSVILSSFGFGGLLYGFSSVGT-YGWTS--ATVLISlIVGAVSLFF-----FILRQSNLKRPMLEF------GV 260
Cdd:cd17352 184 TFVLLALGVSFAMLGFFVPFVYLPSYAKsLGIDEsdAAFLLS-IIGISDIVGrillgLLADKPRIGRLYLYIftllilGL 262
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 494762741 261 FKFAIFSLTTFLGMLVFALLIG--TETILPLYTQNVRGLSALDT-----GLILLPGALFMGFLSPIIGRIFDKVGG 329
Cdd:cd17352 263 SLLAFPLATTYVGLIVFSVLFGfcSGSYSSLTPVILADLVGLEKlsnayGLVLLFQGLAALVGPPIAGLLRDYTGD 338
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
34-171 |
1.37e-07 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 53.36 E-value: 1.37e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 34 AIPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTILASFATNFPVLLAARIVQAAG 113
Cdd:cd17365 21 VAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLG 100
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 494762741 114 AGILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWIVDSFSWKFLFYI 171
Cdd:cd17365 101 LGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLL 158
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
22-240 |
3.85e-07 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 52.14 E-value: 3.85e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 22 FVAILNQTLLIPAIPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTILASFATNFP 101
Cdd:PRK15403 26 FAAYLTTDLIQPGIINVVRDFNADVSLAPASVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATLFTTSMT 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 102 VLLAARIVQAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWIVDSFSWKFLFYIVLPIGIIDLI 181
Cdd:PRK15403 106 QFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWKVLFAIIAVMGLIAFV 185
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 494762741 182 LAFFLMKNVTQQRDTRIDVLSVILS--------SFGFGGLLYGFSSVGTYGWTSATVLISLIVGAVS 240
Cdd:PRK15403 186 GLLLAMPETVKRGAVPFSAKSVLRDfrnvfrnrLFLTGAATLSLSYIPMMSWVAVSPVILIDAGGMT 252
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
8-188 |
4.26e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 51.85 E-value: 4.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 8 YNRSVIVGIFLVGAFVAILNQTLLIPAIPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIF 87
Cdd:cd06173 205 RRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 88 TAGTILASFATNFPVLLAARIVQAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWIVDSFSWKF 167
Cdd:cd06173 285 GLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSA 364
|
170 180
....*....|....*....|.
gi 494762741 168 LFYIvlpIGIIDLILAFFLMK 188
Cdd:cd06173 365 VFLL---AGALLLLAALLLLL 382
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
22-215 |
9.85e-07 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 50.72 E-value: 9.85e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 22 FVAILNQTLLIPAIPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTILASFATNFP 101
Cdd:cd17476 8 LLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFI 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 102 VLLAARIVQAAGAGILMPLMQTIFLTIFPKEK-RGQAMGMVGLVISFAPALGPTLGGWIVDSFSWKFLFYIVLPIGIIDL 180
Cdd:cd17476 88 FFIICRALQGLGPAFLLPNAMALLGRTYPPGPrKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAAIVA 167
|
170 180 190
....*....|....*....|....*....|....*
gi 494762741 181 ILAFFlmknvTQQRDTRIDVLSVILSSFGFGGLLY 215
Cdd:cd17476 168 VAAIF-----WTSPSFIAVLLAVFLGWASFGIWVF 197
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
201-462 |
1.14e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 50.67 E-value: 1.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 201 LSVILSSFGFGGLLYGFSSVGTYGWTSATVLISLI--VGAVSLFFFILRQSNLKRPMLEFGVFKFAIFSLTTFLGMLVFA 278
Cdd:COG2211 158 LGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLglLAFLLTFFGTKERPVPEEEKVSLKESLKALLKNRPFLLLLLAY 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 279 LLIGT-----ETILPLYTQNVRGLSALDTGLILLPGALFMGFLSPIIGRIFDKVGGKGLALGGFTILAVTSLPFMMLSLD 353
Cdd:COG2211 238 LLFFLalalvAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPG 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 354 sSITLITVAYTLRLIGVGMIMMPLTTAGINSLPPHLIPHG-------TAMNNTMRQMGGSIGTAVLVSIMSSSAANAALS 426
Cdd:COG2211 318 -NLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGrrreglyFGIFTFAIKLGQALAGALAGLLLALFGYVAGAA 396
|
250 260 270
....*....|....*....|....*....|....*.
gi 494762741 427 DPMKSAVHGMNTSFIVSGAIAVIGLVLSFFLKEKRK 462
Cdd:COG2211 397 QSPSALTGIRLLFFLLPAVLLLLAALLLLFYPLTRE 432
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
39-193 |
1.68e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 50.24 E-value: 1.68e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 39 MEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTILASFATNFPVLLAARIVQAAGAGILM 118
Cdd:COG0738 238 KDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMF 317
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 494762741 119 PLMQTIFLTIFPKeKRGQAMGMVGLVISFAPALGPTLGGWIVDSFSWKFLFYIVLPIGIIDLILAFFLMKNVTQQ 193
Cdd:COG0738 318 PTIFSLALDGLGK-RTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
19-189 |
2.37e-06 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 49.68 E-value: 2.37e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 19 VGAFVAILNQTLLIPAIPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTILASFAT 98
Cdd:TIGR00881 2 IGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 99 NFPVLLAARIVQAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGG-WIVDSFSWKFLFYIVLPIGI 177
Cdd:TIGR00881 82 SLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLfGIAELYSWHWVFIVPGIIAI 161
|
170
....*....|..
gi 494762741 178 IDLILAFFLMKN 189
Cdd:TIGR00881 162 IVSLICFLLLRD 173
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
14-255 |
4.95e-06 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 48.79 E-value: 4.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 14 VGIFLVGAFVAILNQTLLIPAIPHIMEEFNIDVSK----GQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTA 89
Cdd:cd17388 1 LIFILVTVLLDAMGIGLIMPVLPTLLREFVGDSADaathYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 90 GTILASFATNFPVLLAARIVQAAGAGILMPLMQTIfLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWIVDsFSWKFLF 169
Cdd:cd17388 81 DYLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYI-ADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGE-ISPRAPF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 170 YIVLPIGIIDLILAFFLMKNvTQQRDTRIDVLSVILSSFGFGGLLYGFSSVG--------------------------TY 223
Cdd:cd17388 159 LVAAGLNGLNFLLGLFVLPE-SLPPERRRAFRWRRANPFGSLRWLTGFPGLLgllavffliqligqvpattwvlftedRF 237
|
250 260 270
....*....|....*....|....*....|..
gi 494762741 224 GWTSATVLISLivgAVSLFFFILRQSNLKRPM 255
Cdd:cd17388 238 DWSPTMVGLSL---AVFGLLHALFQAFVTGPI 266
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
77-188 |
6.25e-06 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 48.48 E-value: 6.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 77 RSLVLTALSIFTAGTILASFATNFPVLLAARIVQAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLG 156
Cdd:PRK10473 68 KPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLG 147
|
90 100 110
....*....|....*....|....*....|..
gi 494762741 157 GWIVDSFSWKFLFYIVLPIGIIDLILAFFLMK 188
Cdd:PRK10473 148 HLIMLKFPWQSLFYTMAAMGILVLLLSLFILK 179
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
73-194 |
6.92e-06 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 47.93 E-value: 6.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 73 KFSSRSLVLTALSIFTAGTILASFATNFPVLLAARIVQAAGAGILMPLMQTI---FLTIFPKEKRGQAMGMVGLVISFAP 149
Cdd:cd17471 59 GGDRKPLILLALLAGALGYLLFAFLRNYWVLLLVGVVLLSLGAAAFPQLFALareYADRSSGRDATLFNSVLRAAFSLAW 138
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 494762741 150 ALGPTLGGWIVDSFSWKFLFYIVLPIGIIDLILAFFLMKNVTQQR 194
Cdd:cd17471 139 VIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVKPPA 183
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
17-457 |
8.85e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 48.00 E-value: 8.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 17 FLVGAFVAILNQTLLIPAIPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTILASF 96
Cdd:cd06173 4 LWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLAL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 97 AT-----NFPVLLAARIVQAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWIVDSFSWKFLFYI 171
Cdd:cd06173 84 LAllgslSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAI 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 172 VLPIGIIDLILAFFLMKNVTQQRDTRidvlsvilssfgfggllygfssvgtygwtsatvlISLIVGAVSLFFFILRQSNL 251
Cdd:cd06173 164 NALSFLLSALLLLFIRRPPPAAPGES----------------------------------SSLLLRDLREGLRYLRRSPL 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 252 KRPMLefgvfkfaifslttFLGMLVFALLIGTETILPLYTQNVRGLSALDTGLILLPGALFMGFLSPIIGRIFDKVGGKG 331
Cdd:cd06173 210 LRLLL--------------LALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGR 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 332 LALGGFTILAVTSLPFmmlSLDSSITLITVAYTLRLIGVGMIMMPLTTAGINSLPPHLIPHGTAMNNTMRQMGGSIGtAV 411
Cdd:cd06173 276 LLLIGALLLGLALLVL---GLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLG-AL 351
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 494762741 412 LVSIMsssaanaalsdpmkSAVHGMNTSFIVSGAIAVIGLVLSFFL 457
Cdd:cd06173 352 LAGLL--------------ADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
11-188 |
1.04e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 47.57 E-value: 1.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 11 SVIVGIFLVGAFVAILNQTLLIPAIPHIMEEFNIDVSKGQWLTTAF----MLTNGILIPItafLIEKFSSRSLVLTALSI 86
Cdd:cd17330 174 PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVgiagILAQLLLIPR---LAKRLGERKLLRLGLLL 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 87 FTAGTILASFATNFPVLLAARIVQAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWIVDSFSWK 166
Cdd:cd17330 251 AIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPG 330
|
170 180
....*....|....*....|..
gi 494762741 167 FLFYIVlpiGIIDLILAFFLMK 188
Cdd:cd17330 331 VPFLLA---AGLLLIALFLLSL 349
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
54-184 |
1.49e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 47.15 E-value: 1.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 54 TAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTILASFATNFPVLLAARIVQAAGAGILMPLMQTIFLTIFPKEK 133
Cdd:cd17370 241 ALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAEL 320
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 494762741 134 RGQAMGMVGLVISFAPALGPTLGGWIVDSFSWKFLFYIVLPIGIIDLILAF 184
Cdd:cd17370 321 RGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
69-372 |
1.62e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 46.83 E-value: 1.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 69 FLIEKFSSRSLVLTALSIFTAGTILASFATNFPVLLAARIVQAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFA 148
Cdd:cd17316 58 YLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALG 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 149 PALGPTLGGWIVDSFSWKFLFYIVLPIGIIDLILAFFLmknvtqqrdtRIDVLSVILSSFGFGGLLYGFSsvgtygwtsa 228
Cdd:cd17316 138 ALLAALVASLLIPLLSGDWGWRILFLIGALPALLALLL----------RRRTLLLILLWFFISFGYYGLT---------- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 229 tvlislivgavslfffilrqsnlkrpmlefgvfkfaifslttflgmlvfalligteTILPLYTQNVRGLSALDTGLILLP 308
Cdd:cd17316 198 --------------------------------------------------------TFLPTYLQTVLGLSPATSSLYLLL 221
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 494762741 309 GALFMGFLSPIIGRIFDKVGGKGLALGGFTILAVTSLPFMMLSLDSSITLITVAYTLRLIGVGM 372
Cdd:cd17316 222 ISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGV 285
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
36-184 |
4.79e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 45.62 E-value: 4.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 36 PHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTILASFATNFPVLLAARIVQAAGAG 115
Cdd:cd17324 223 PFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFF 302
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 494762741 116 ILMPLMQTIFLTIFPkEKRGQAMGMVGLVISFAPALGPTLGGWIVDSFSWKFLFYIVLPIGIIDLILAF 184
Cdd:cd17324 303 AAHSALQTRVLRLAP-EARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
57-187 |
4.80e-05 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 45.28 E-value: 4.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 57 MLTNGILIPITAFLIEKFSSRSLVLTA--LSIFTAGTILASFATNFPVLLAARIVQAAGAGILMPLMQTIFLTIFPKEKR 134
Cdd:cd17472 239 ILIGFILMVPFVIYAEKKGKMKQVFVSsiLLIAVGFLLLLFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYR 318
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 494762741 135 GQAMGMVGLVISFAPALGPTLGGWIVDSFSWKFLFYIVLPIGIIDLILAFFLM 187
Cdd:cd17472 319 GTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILILALLWLLVSFLLP 371
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
29-392 |
4.85e-05 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 45.32 E-value: 4.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 29 TLLIPAIPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTI-LASFATNFPVLLAAR 107
Cdd:cd17341 16 FLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLaLALAVSSYWGLLVLG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 108 IVQAAGAGILMPLMQTIFlTIFPKEKRGQA------MGMVGLVIS--FAPALGpTLGGWIVDSFSWKFLFYIVLPIGIID 179
Cdd:cd17341 96 FLLGFAGANFASGQPWAS-FWFPKEKIGGAaggiagAGNMGVAVSqlLAPLIA-GAIVFDGGFVGWRNAFFVPGILLAIA 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 180 LILAFFLMKNVTQQRDTRIDVLSVILSSFGFG-----GLLYGFSsvgtygwtsatvlislivgavslfffilrqsnlkrp 254
Cdd:cd17341 174 AVLVLLFGDDLPTGKASALEFLKVQLAVLKNYrtwilSLLYGVT------------------------------------ 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 255 mleFGVFkfaifslttflgmlvfallIGTETILPLYTQNVRGLSALDTGLILLPGALFMGFLSPIIGRIFDKVGGKGLAL 334
Cdd:cd17341 218 ---FGSF-------------------VGFSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLW 275
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 494762741 335 GGFTILAVTSLPFMMLSLDSSITLITVAytlrligVGMIMMPLTTAGINSLPPHLIPH 392
Cdd:cd17341 276 WLFIVMTIGAALLSLSLPTSGTNLVLFL-------ALFVALGLGAGAGNGSVFRMVPF 326
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
85-188 |
5.43e-05 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 45.24 E-value: 5.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 85 SIFTAGTILASfATNFPVLLAARIVQAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWIVDSFS 164
Cdd:cd17380 75 SLATLLTPLLA-YSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYG 153
|
90 100
....*....|....*....|....
gi 494762741 165 WKFLFYIvlpIGIIDLILAFFLMK 188
Cdd:cd17380 154 WPSVFYF---FGLLGLLWALVWLI 174
|
|
| PRK03545 |
PRK03545 |
putative arabinose transporter; Provisional |
69-188 |
6.40e-05 |
|
putative arabinose transporter; Provisional
Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 45.27 E-value: 6.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 69 FLIEKFSSRSLVLTALSIFTAGTILASFATNFPVLLAARIVQAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFA 148
Cdd:PRK03545 66 LLTSNVERRKLLIGLFVLFIASHVLSALAWNFTVLLISRIGIAFAHAIFWSITASLAIRVAPAGKKAQALSLLATGTALA 145
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 494762741 149 PALGPTLGGWIVDSFSWKFLFYIvlpIGIIDLILAFFLMK 188
Cdd:PRK03545 146 MVLGLPLGRVIGQYLGWRTTFLA---IGGGALITLLLLIK 182
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
35-198 |
8.80e-05 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 44.70 E-value: 8.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 35 IPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTILASFATNFPVLLAARIVQAAGA 114
Cdd:PRK10091 26 LTELAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIGNAMFTLSSSYLMLAIGRLVSGFPH 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 115 GILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWIVDSFSWKFLFYIVLPIGIIDLILAFFLMKNVTQQR 194
Cdd:PRK10091 106 GAFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQEFSWRYTFLLIAVFNIAVLASIYFWVPDIRDEA 185
|
....
gi 494762741 195 DTRI 198
Cdd:PRK10091 186 KGGL 189
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
30-189 |
1.46e-04 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 43.80 E-value: 1.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 30 LLIPAIPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTILASFATNFPVLLAARIV 109
Cdd:cd17312 21 NFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 110 QAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWIVDSFSWKFLFYIVLPIGIIDLILAFFLMKN 189
Cdd:cd17312 101 NGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRD 180
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
65-215 |
3.25e-04 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 43.03 E-value: 3.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 65 PITAFLIEKFSSRSLVLTALSIFTAGTILASFATNFPVLLAARIVQAAGAGILMpLMQTIFLTIFPKEKRGQAMGMVGLV 144
Cdd:cd17389 82 PITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVS-LSTAIVADVTSPKKRSKGMALIGVA 160
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 494762741 145 ISFAPALGPTLGGWI--------VDSFSWKFLFYIVLpiGIIDLILAFFLMKNvTQQRDTRIDVLSVILSSFGFGGLLY 215
Cdd:cd17389 161 FSLGFIIGPMIGAYFasftrslgEVFFSMPALFALVL--ALADLLFIFFFLPE-TLPSNLRRLGLVYFLYLFLFSGLEF 236
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
58-188 |
4.10e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 42.64 E-value: 4.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 58 LTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTILASFATNFPVLLAARIVQAAGAGiLMPLMQTIFLTIFPKEKRGQA 137
Cdd:cd17391 47 LVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSG-YVPNATALIASQTPKEKSGWA 125
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 494762741 138 MGMVGLVISFAPALGPTLGGWIVDSFSWKFLFYIVLPIGIIDLILAFFLMK 188
Cdd:cd17391 126 LGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLFFVK 176
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
34-186 |
5.34e-04 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 42.17 E-value: 5.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 34 AIPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTILASFATNFPVLLAARIVQAAG 113
Cdd:cd17359 23 ALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 114 AGILMPLMQTIFLTIFPKEKRG------QAMGMVGLVISFAP--ALGPTLGGWIVDSFSWKFLFYIVLPIGIIDLILAFF 185
Cdd:cd17359 103 VGGASALVPMYIAEVAPAEIRGrlvslnQLMIVFGQLLAYIVnyLIANAGGADWLGAEGWRWMLGLEAIPAILFLLGMLF 182
|
.
gi 494762741 186 L 186
Cdd:cd17359 183 I 183
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
268-459 |
5.75e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 42.20 E-value: 5.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 268 LTTFLGMLVFALLIgteTILPLYTQNVrGLSALDTGLILLPGALFMGFLSPIIGRIFDKVGGKGLALGGFTILAVTSLpf 347
Cdd:cd17489 3 LANFFFFLSFYLLL---PVLPLYAHDL-GGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATL-- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 348 mMLSLDSSITLITVAYTLRLIGVGMIMMPLTTAGINSLPPHLIPHGTAMNNTMRQMGGSIGTAVLVSIMSSSaanaalsd 427
Cdd:cd17489 77 -LYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHL-------- 147
|
170 180 190
....*....|....*....|....*....|..
gi 494762741 428 pmksavhGMNTSFIVSGAIAVIGLVLSFFLKE 459
Cdd:cd17489 148 -------GFAVLFIVAAVLALLALLLVFLVKD 172
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
72-253 |
6.60e-04 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 41.99 E-value: 6.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 72 EKFSSRSLVLTALSIFTAGTILASFATNFPVLLAARIVQAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPAL 151
Cdd:PRK03893 80 DRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVV 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 152 GPTLGGWIVDSFSWKFLFYivlpIGIIDLILAFFLMKNVTQQRD------------TRIDVL--------SVILSSFGFG 211
Cdd:PRK03893 160 AAQVYSLVVPVWGWRALFF----IGILPIIFALWLRKNLPEAEDwkekhagkapvrTMVDILyrgehriiNILLTLAAAA 235
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 494762741 212 GLLYGFSSVGTYGWtsatVLISLIVGAVSLFFFILRQSNLKR 253
Cdd:PRK03893 236 ALWFCFAGNLQNAA----IVAVLGLLCAAIFISFMVQSSGKR 273
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
65-194 |
7.00e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 41.83 E-value: 7.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 65 PITAFLIEKFSSRSLVLTALSIFTAGTILASFATNFPVLLAARIVQAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLV 144
Cdd:cd17329 53 LIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWA 132
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 494762741 145 ISFAPALGPTLGGWIVD-SFSWKFLFYIVLPIGIIdLILAFFLMKNVTQQR 194
Cdd:cd17329 133 INLGVAIGPLLGGLLLLySFRLLFLAAAVLFLLAA-LVLLFLLPETRPKRR 182
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
14-243 |
7.76e-04 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 41.79 E-value: 7.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 14 VGIFLVGAFVAILNqtlliPAIPHIMEEFNIDVSKGQW-LTTAFMLTNGILIPITA-FLIEKFSSRSLVLTALSIFTAGT 91
Cdd:cd17315 4 LGGLLFGYDLGVIN-----GALLYIAKDLGFGLSTSLQgLVVSSLLLGAAIGSLFGgPLADRFGRRKSLLIAAVLYVIGA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 92 ILASFATNFPVLLAARIVQAAGAGIlmplmQTIFLTIF-----PKEKRG------QAMGMVGLVISFAPALGPTLGGWIv 160
Cdd:cd17315 79 LLSALAPNVWVLIVGRFLLGLGVGL-----ASVLVPLYiseiaPAKIRGalgtlnQLMITFGILLAYLLGLALSLSPPG- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 161 dsfSWKFLFYIVLPIGIIDLILAFFLmknvtqqRDTRIDVLSVILSSF----GFGGLLYGFSSV-GTYGWTSATVLISLI 235
Cdd:cd17315 153 ---WWRLMFALAAVPALLQLLLMFFL-------PESRALLVGVGLQLLqqltGINAVMYYAPTIfKSAGGGTASILASII 222
|
....*...
gi 494762741 236 VGAVSLFF 243
Cdd:cd17315 223 VGVVNLLA 230
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
268-391 |
7.82e-04 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 41.74 E-value: 7.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 268 LTTFLGMLVFALLIGTETILPL-YTQNVRGLSALDTGLILLPGALFMGFLSPIIGRIFDKVGGKGLALGGFTILAVTSLP 346
Cdd:cd17369 231 LLAIGLRLAENVLFYLFTTFALsYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFP 310
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 494762741 347 FMMLSLDSSITLITVAytlrLIGVGMIMMPLTTAGINSLPPHLIP 391
Cdd:cd17369 311 FFWLLDTGSTWLIVLA----AVVVLGVLHGMMYGPQAAFLAELFP 351
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
266-463 |
8.69e-04 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 41.41 E-value: 8.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 266 FSLTTFLGMLVFALLIgteTILPLYTQNVrGLSALDTGLILLPGALFMGFLSPIIGRIFDKVGGKGLALGGFTILAVTSL 345
Cdd:cd17325 1 LSLALFLDMLGYGIII---PILPLYAESL-GASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 346 PFMMLSldsSITLITVAYTLRLIGVGMIMMPLTTAGINSLPPHLIPHGTAMNNTMRQMGGSIGtAVLVSIMsssaanaal 425
Cdd:cd17325 77 LFAFAT---SYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIG-PLLGGLL--------- 143
|
170 180 190
....*....|....*....|....*....|....*...
gi 494762741 426 sdpmkSAVHGMNTSFIVSGAIAVIGLVLSFFLKEKRKN 463
Cdd:cd17325 144 -----ADALGYRAPFLVCAALALLALVLALLLLPEPRP 176
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
70-186 |
9.35e-04 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 41.45 E-value: 9.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 70 LIEKFSSRSLVLTAL---SIFTAGTILASfATNFPVLLAARIVQAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLVIS 146
Cdd:cd17318 79 LAEKYGAKRVLGYSIlitALLTLLTPLAA-RGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQ 157
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 494762741 147 FAPALGPTLGGWIVDSFSWKFLFYIVLPIGIIDLILAFFL 186
Cdd:cd17318 158 FGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFL 197
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
66-189 |
1.19e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 41.07 E-value: 1.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 66 ITAFLIEKFSSRSLVLTALSIFTAGTILASFATNFPVLLAARIVQAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLVI 145
Cdd:cd17475 50 PAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGV 129
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 494762741 146 SFAPALGPTLGGWIVDSFSWKFLFYIVLPIGIIDLILAFFLMKN 189
Cdd:cd17475 130 PLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYRE 173
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
14-153 |
1.36e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.86 E-value: 1.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 14 VGIFLVGAFVAILNQTLLIPAIPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRS---LVLTALSIFTAG 90
Cdd:pfam07690 202 VLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRrllLALLLLILAALG 281
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 494762741 91 TILASFATNFPVLLAARIVQAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGP 153
Cdd:pfam07690 282 LLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
29-197 |
2.91e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 39.89 E-value: 2.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 29 TLLIPAIPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSR-SLVLTALSIFTAGTILAsFATNFPVLLAAR 107
Cdd:cd17331 17 WLQQPVLPYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRaALVLSFLSSALSYLLLA-FASSVPMLFLSR 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 108 IVQAAGAGilMPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWIVDSFSWKFLFYIVLPIGIIDLILAFFLM 187
Cdd:cd17331 96 LPSVFMHA--MQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLI 173
|
170
....*....|
gi 494762741 188 KNVTQQRDTR 197
Cdd:cd17331 174 PSNTKSKREK 183
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
38-185 |
3.29e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 39.51 E-value: 3.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 38 IMEEFNIDVSKGQWLTTAF----MLTNGILIPItafLIEKFSSRSLVLTALSIFTAGTILASFATNFPVLLAARIVQAAG 113
Cdd:cd17331 234 AMDFFGLTPEENGYLMSYAgvlgMVVQGLLVGP---LTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIG 310
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 494762741 114 AGILMPLMQTIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGWIVDSFSWKFLFYIVLPIGIIDLILAFF 185
Cdd:cd17331 311 GSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAINGLLTVYLLL 382
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
30-190 |
3.34e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 39.59 E-value: 3.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 30 LLIPAIPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTILASFATNFPVLLAARIV 109
Cdd:cd17371 17 LLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 110 QAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVGLVIS----FAPALGPTLGGWIVDSFSWKFLFYivlpIGIIDLILAFF 185
Cdd:cd17371 97 AGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAvgwlLATLLAALLFPLLPPEIAWRVLFL----LGALPALLVLF 172
|
....*
gi 494762741 186 LMKNV 190
Cdd:cd17371 173 IRRFV 177
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
285-459 |
3.76e-03 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 39.65 E-value: 3.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 285 TILPLYTQNVRGLSALDTGLILLPGALFMGFLSPIIGRIFDKVGGKGLALGGFTILAVTSLPFMMLSLDSSITLItvayt 364
Cdd:cd17366 214 SYMPSYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAGLAGLLVLAVPAFLLMNSGSIAAI----- 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 365 lrLIGVGMIMMPLT--TAGINSLPPHLIPhgtamnNTMRQMGGSIGTAVLVSI------MSSSAANAALSDPMKSAVHGM 436
Cdd:cd17366 289 --FIGLLVLGLLLScyTATMASTLPALFP------THVRYSALAIAFNISVSLfggttpLVASWLVSATGNPLMPAYYLM 360
|
170 180
....*....|....*....|...
gi 494762741 437 ntsfivsgAIAVIGLVLSFFLKE 459
Cdd:cd17366 361 --------VAAVVGLVAVLFLTE 375
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
13-165 |
4.24e-03 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 39.48 E-value: 4.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 13 IVGIFLVgAFVAILNQTLLIPAIPHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTI 92
Cdd:cd17339 1 ILGIVLI-AFNLRPAITSVGPLLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGIL 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 494762741 93 LASFaTNFPVLLAARIVQAAGAGILMPLMQTIFLTIFPkEKRGQAMGMVGLVISFAPALGPTLGGWIVDSFSW 165
Cdd:cd17339 80 LRSL-GGIALLFLGTALAGAGIAVGNVLLPSLIKRDFP-RRVGLMTGLYTTSMNLGAALASGLSVPLAQALGG 150
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
73-186 |
5.05e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 39.13 E-value: 5.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 73 KFSSRSLVLTALSIFT-AGTILASFATNFPVLLAARIVQAAGAGILMPLMqTIFLTIFPKEKRGQAMGMVGLVISFAPAL 151
Cdd:cd17490 57 RIGKRKLFIIIGLLFTvLASLIMILFPSPWGLLIARFLSGIAAATWVSFT-VLYASYFPPDEAAKAMGLINLVNNLGQLI 135
|
90 100 110
....*....|....*....|....*....|....*
gi 494762741 152 GPTLGGWIVDSFSWKFLFYIVLPIGIIDLILAFFL 186
Cdd:cd17490 136 AFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFI 170
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
66-186 |
8.12e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 38.41 E-value: 8.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 66 ITAFLIEKFSSRSLVLTALSIFTAGTILASFAT---NFPVLLAARIVQAAGAGILMPLMQTIFLTIFPKEKRGQAMGMVG 142
Cdd:pfam00083 65 FAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQ 144
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 494762741 143 LVISFAPALGPTLG---GWIVDSFSWKFLFYIVLPIGIIDLILAFFL 186
Cdd:pfam00083 145 LAITFGILLAYIFGlglNKTSNSDGWRIPLGLQLVPALLLIIGLLFL 191
|
|
| MFS_SLC18A3_VAChT |
cd17383 |
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ... |
12-195 |
8.54e-03 |
|
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340941 [Multi-domain] Cd Length: 378 Bit Score: 38.45 E-value: 8.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 12 VIVGIFLvgafvaILNQTLLIPAIPHIMEEFNIDVSKGqWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGT 91
Cdd:cd17383 2 VIVCIAL------LLDNMLYMVIVPIIPDYLNEDIAIG-VLFASKAIVQLLVNPFSGTLIDRVGYDIPMMIGLTVMFLST 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 92 ILASFATNFPVLLAARIVQAAG------AGILMplmqtIFLTIFPKEKRGQAMGMVGLVISFAPALGPTLGGwIVDSFSW 165
Cdd:cd17383 75 AVFAFGESYAVLFFARSLQGVGsafadtAGLAM-----IADRFTEEAERSKALGIALAFISFGCLVAPPFGG-ILYEFAG 148
|
170 180 190
....*....|....*....|....*....|.
gi 494762741 166 KFLFYIVLP-IGIIDLILAFFLMKNVTQQRD 195
Cdd:cd17383 149 KEVPFLILAfVCLLDGLLLLLVMKPVRRETR 179
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
50-250 |
9.35e-03 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 38.38 E-value: 9.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 50 QWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTILASFATNFPVLLAARIVQAAGAGILMPLMQTIFLTIF 129
Cdd:cd17327 44 NWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWY 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 130 PKEKRGQAMGmvglvISFAPA-LGPTLGGWIVDSF----------SWKFLFYIVLPIGIIDLILAFFLMKNVTQQ----- 193
Cdd:cd17327 124 KREEQAKRIA-----FFYAAAgLGSIFGGLLAYGVfkilgvgglaGWRWLFIIEGLITIIIGLVIFFWLPDNPSKawflt 198
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 494762741 194 --------RDTRIDVLSVILSSFGFGGLLYGFSSVGTYGWTSATVLISLIVGAVSLFFFILRQSN 250
Cdd:cd17327 199 eeekelavERLRANQTGKGDQKFKWKQIKEAFKDPRTWLLFLFFFCSQITNNGISNFLPLILKSL 263
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
36-187 |
9.88e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 38.36 E-value: 9.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494762741 36 PHIMEEFNIDVSKGQWLTTAFMLTNGILIPITAFLIEKFSSRSLVLTALSIFTAGTILASFATNFP-VLLAARIVQAAGA 114
Cdd:cd17353 27 PPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPlLFLGYGVLGGIGA 106
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 494762741 115 GILMPLMQTIFLTIFPkEKRGQAMGMVGLVISFAPALGPTLGGWIVDSFSWKFLFYIvlpIGIIDLILAFFLM 187
Cdd:cd17353 107 GIGYITPVSTAVKWFP-DKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLI---LGIIFLIIIVIGA 175
|
|
| |
