|
Name |
Accession |
Description |
Interval |
E-value |
| NPCBM |
pfam08305 |
NPCBM/NEW2 domain; This novel putative carbohydrate binding module (NPCBM) domain is found at ... |
1620-1761 |
1.51e-48 |
|
NPCBM/NEW2 domain; This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins. This domain has also been called the NEW2 domain (Naumoff DG. Phylogenetic analysis of alpha-galactosidases of the GH27 family. Molecular Biology (Engl Transl). (2004)38:388-399.)
:
Pssm-ID: 429907 Cd Length: 137 Bit Score: 169.66 E-value: 1.51e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 1620 ETYISDLSWKSATIGSGAIGKDISVRRETIQIRNedgsyQAYEKGIGTHAQSEIVYD-SADYDIFDTWVGLDRYVagESV 1698
Cdd:pfam08305 2 EVYLSDLPWLSATNGWGPVERDRSNDGNPLTIGG-----VTYAKGLGTHAPSELTYDlGGKCTRFTAVVGVDDEV--GGK 74
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 494496751 1699 ASVNFKIYVDGVLKAETGIMKADTPKKRLVVDVRGSKQIKLVADQATNGNNWDHADWADAKFR 1761
Cdd:pfam08305 75 GSVRFEVYGDGKELYTSGVLTGGDPAVAVDVDVTGAKRLRLVVTDGGDGNNYDHADWADAKLT 137
|
|
| NPCBM |
pfam08305 |
NPCBM/NEW2 domain; This novel putative carbohydrate binding module (NPCBM) domain is found at ... |
880-1019 |
1.41e-45 |
|
NPCBM/NEW2 domain; This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins. This domain has also been called the NEW2 domain (Naumoff DG. Phylogenetic analysis of alpha-galactosidases of the GH27 family. Molecular Biology (Engl Transl). (2004)38:388-399.)
:
Pssm-ID: 429907 Cd Length: 137 Bit Score: 161.19 E-value: 1.41e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 880 DYDYLSDFKWESATTVWGTPRRNSNIQGR---VNGQTerFEKGFGIHANGKITYDLsDKQYDRFEALLGVDPSAidpNNN 956
Cdd:pfam08305 1 GEVYLSDLPWLSATNGWGPVERDRSNDGNpltIGGVT--YAKGLGTHAPSELTYDL-GGKCTRFTAVVGVDDEV---GGK 74
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 494496751 957 SSVKFKIIADGKTLTSTNVLGYYDNMVYVNVPVSGVKKLVIEVSDAENGNTADHCIIVNPKLT 1019
Cdd:pfam08305 75 GSVRFEVYGDGKELYTSGVLTGGDPAVAVDVDVTGAKRLRLVVTDGGDGNNYDHADWADAKLT 137
|
|
| NPCBM |
pfam08305 |
NPCBM/NEW2 domain; This novel putative carbohydrate binding module (NPCBM) domain is found at ... |
1396-1537 |
2.20e-45 |
|
NPCBM/NEW2 domain; This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins. This domain has also been called the NEW2 domain (Naumoff DG. Phylogenetic analysis of alpha-galactosidases of the GH27 family. Molecular Biology (Engl Transl). (2004)38:388-399.)
:
Pssm-ID: 429907 Cd Length: 137 Bit Score: 160.42 E-value: 2.20e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 1396 KSTYLSDMNWESAKTGWRTVTKDTAVgssDKIKLNVDGKvkTFDKGIGAATNAEIVYNLDGNYNYFTTYLGTDKNYDMDS 1475
Cdd:pfam08305 1 GEVYLSDLPWLSATNGWGPVERDRSN---DGNPLTIGGV--TYAKGLGTHAPSELTYDLGGKCTRFTAVVGVDDEVGGKG 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 494496751 1476 TtIRFRILADGKEVYTSDVIRKNTPAEFVNLDVTGVKKLVLVADDVDGNLVGDFASWADTKV 1537
Cdd:pfam08305 76 S-VRFEVYGDGKELYTSGVLTGGDPAVAVDVDVTGAKRLRLVVTDGGDGNNYDHADWADAKL 136
|
|
| Peptidase_M60 super family |
cl24257 |
Peptidase M60, enhancin and enhancin-like; This family of peptidases contains a zinc ... |
416-682 |
9.66e-16 |
|
Peptidase M60, enhancin and enhancin-like; This family of peptidases contains a zinc metallopeptidase motif (HEXXHX(8,28)E) and possesses mucinase activity. It includes the viral enhancins as well as enhancin-like peptidases from bacterial species. Enhancins are a class of metalloproteases found in some baculoviruses that enhance viral infection by degrading the peritrophic membrane (PM) of the insect midgut. Bacterial enhancins are found to be cytotoxic when compared to viral enhancin, however, suggesting that the bacterial enhancins do not enhance infection in the same way as viral enhancin. Bacterial enhancins may have evolved a distinct biochemical function. These bacterial domains are peptidases targetting host glycoproteins and thus probably play an important role in successful colonization of both vertebrate mucosal surfaces and the invertebrate digestive tract by both mutualistic and pathogenic microbes. This family has been augmented by a merge with the sequences in the Enhancin Pfam family.
The actual alignment was detected with superfamily member pfam13402:
Pssm-ID: 433178 [Multi-domain] Cd Length: 268 Bit Score: 79.35 E-value: 9.66e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 416 GGEEFPLYNEGDDKDAfleklkAYKEKLDKNPDTtvdIFEFNTKRLLYTGTAKAAYQvyvKEGVDVGESIQVWnDKIQEA 495
Cdd:pfam13402 1 GAVRAPYFVYGKTTDE------EWEEMLRNYPAP---WAELDGGRVILTVPSEFLRQ---LDRLNPQALWRLW-DRVMYS 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 496 FD-FAGLKDDPSDPTndSTNVRTTIRLMQPYGAAYAAYGHVGIQRGIQEIALRTDkDSINSILWGMVHEVGHQMDIS--- 571
Cdd:pfam13402 68 VNeVAGLPRRSDGRV--TRPVRFVFDRQISAGFMHAGYPIMAFPPGSASELVNYD-SARKSGCWGPLHELGHNFQQRwgw 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 572 --EREWGEITNNMFanNAYINNGAGDrvPYSQIQTSLAPDD-ASTNFDNLDYSQR-----------LGMFWQL--HLKDN 635
Cdd:pfam13402 145 twPGHTGEVTNNIL--SLYVQELLTG--IDSTRQINFNGRArWGPALGGWARDKHakeylnkgkdlLVFYGQLlyYFGWD 220
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 494496751 636 TYwAEVEKLYRKRKPSVSN--EQAKRDTFAKYASEVLNMNLTKHFEKYG 682
Cdd:pfam13402 221 FY-RKLFRAYRTQPYLPRNnsDGDKMSEFMLTFSKVAKRDLRPFFKAWG 268
|
|
| DUF5011 super family |
cl47259 |
Domain of unknown function (DUF5011); This entry represents a bacterial immunoglobulin-like ... |
1321-1393 |
7.36e-13 |
|
Domain of unknown function (DUF5011); This entry represents a bacterial immunoglobulin-like domain.
The actual alignment was detected with superfamily member pfam16403:
Pssm-ID: 435320 [Multi-domain] Cd Length: 71 Bit Score: 65.26 E-value: 7.36e-13
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 494496751 1321 TLKFEEFTMVKKNSEFNLMdGVVADDKeDGDITNKVVVDnGGFNPNKVGTYTVTYTITDKDSNITTKQRTIVV 1393
Cdd:pfam16403 2 TLNGDNDITIELGTTYEDP-GATATDN-DGDLTDKVKVT-GSVDTSKPGTYTLTYTVTDSDGNSATVTRTVTV 71
|
|
| F5_F8_type_C |
pfam00754 |
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family. |
1124-1254 |
5.52e-12 |
|
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
:
Pssm-ID: 459925 [Multi-domain] Cd Length: 127 Bit Score: 64.78 E-value: 5.52e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 1124 PIKSVKNNAGNYqssVITNAIDGKINTHWetdSPNNNSFKNEVTFDLGEVQEISKIAYASRRDGNfKGFATQFEIYVSES 1203
Cdd:pfam00754 1 QITASSSYSGEG---PAAAALDGDPNTAW---SAWSGDDPQWIQVDLGKPKKITGVVTQGRQDGS-NGYVTSYKIEYSLD 73
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 494496751 1204 ESGDDFYLAG--QGSYSGAISDVVEFNVSkVKARRVKFKFVQA--SGDWASFSEV 1254
Cdd:pfam00754 74 GENWTTVKDEkiPGNNDNNTPVTNTFDPP-IKARYVRIVPTSWngGNGIALRAEL 127
|
|
| LRR super family |
cl34836 |
Leucine-rich repeat (LRR) protein [Transcription]; |
1849-1973 |
4.91e-09 |
|
Leucine-rich repeat (LRR) protein [Transcription];
The actual alignment was detected with superfamily member COG4886:
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 60.72 E-value: 4.91e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 1849 KQLNLSG-QIT-----VGDMRKLVSLNLS--QVESLEGLQYAINLQSLNIQYNEIRDLSPLKNLKKLT--DLKANPIGGL 1918
Cdd:COG4886 208 EELDLSGnQLTdlpepLANLTNLETLDLSnnQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKtlDLSNNQLTDL 287
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 494496751 1919 MSTNIrpQNNKATINFDFINREGKKLAPTLITLKNNKTQEVKQLNVGECVDENGL 1973
Cdd:COG4886 288 KLKEL--ELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTL 340
|
|
| DUF5011 super family |
cl47259 |
Domain of unknown function (DUF5011); This entry represents a bacterial immunoglobulin-like ... |
1029-1097 |
4.99e-09 |
|
Domain of unknown function (DUF5011); This entry represents a bacterial immunoglobulin-like domain.
The actual alignment was detected with superfamily member pfam16403:
Pssm-ID: 435320 [Multi-domain] Cd Length: 71 Bit Score: 54.48 E-value: 4.99e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 494496751 1029 AEDKYIKLGQDFdVREGVKAHDQeDGDLTAQIQVESNTFVkDKIGKYEVVYKVADKDGNETTKKINVTV 1097
Cdd:pfam16403 6 DNDITIELGTTY-EDPGATATDN-DGDLTDKVKVTGSVDT-SKPGTYTLTYTVTDSDGNSATVTRTVTV 71
|
|
| F5_F8_type_C |
pfam00754 |
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family. |
115-225 |
2.17e-07 |
|
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
:
Pssm-ID: 459925 [Multi-domain] Cd Length: 127 Bit Score: 51.68 E-value: 2.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 115 KAFDDEVETYWASSklnSDTFKNEIVVTLKESTKIDTMIYGGTPHWQKGYAEQFEIYASNtdEGDDFRLIATGEQPANHD 194
Cdd:pfam00754 16 AALDGDPNTAWSAW---SGDDPQWIQVDLGKPKKITGVVTQGRQDGSNGYVTSYKIEYSL--DGENWTTVKDEKIPGNND 90
|
90 100 110
....*....|....*....|....*....|....*
gi 494496751 195 ---IKEINF-TPTKLKRLKFVFKKGNLNQAACSVF 225
Cdd:pfam00754 91 nntPVTNTFdPPIKARYVRIVPTSWNGGNGIALRA 125
|
|
| DUF5011 super family |
cl47259 |
Domain of unknown function (DUF5011); This entry represents a bacterial immunoglobulin-like ... |
1546-1614 |
5.22e-07 |
|
Domain of unknown function (DUF5011); This entry represents a bacterial immunoglobulin-like domain.
The actual alignment was detected with superfamily member pfam16403:
Pssm-ID: 435320 [Multi-domain] Cd Length: 71 Bit Score: 48.70 E-value: 5.22e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 494496751 1546 IKGDDVVVFDVKEKVDLlQGITATDfEDGDITSCIQIETDYTQGKAGVFEVVYSVTDNDGFTTKFTRKV 1614
Cdd:pfam16403 3 LNGDNDITIELGTTYED-PGATATD-NDGDLTDKVKVTGSVDTSKPGTYTLTYTVTDSDGNSATVTRTV 69
|
|
| M60-like_N super family |
cl38578 |
N-terminal domain of M60-like peptidases; This accessory domain has a jelly roll topology. |
293-414 |
1.97e-05 |
|
N-terminal domain of M60-like peptidases; This accessory domain has a jelly roll topology.
The actual alignment was detected with superfamily member pfam17291:
Pssm-ID: 435844 [Multi-domain] Cd Length: 106 Bit Score: 45.41 E-value: 1.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 293 TDRTFTLTQNGHThsksrnvlrmsrlgTDLQSTGIVARPGQVFKIFVEADSNTKLpQIVFTQQEGHFSH---W------Q 363
Cdd:pfam17291 4 TREKARVRINSRY--------------SDWQSTGLYAPPGELITIEVPDNAVGKL-VVQIGCHTDNLGHadeLfrppvvT 68
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 494496751 364 KEYQLKKGLNVITVPeiysdswsqksvKGGAVYLmnRYTADEQGKAPVVRI 414
Cdd:pfam17291 69 CRFPLDEGVNKISWP------------YGGLIYI--IVPIDTFEGAVEVTI 105
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| NPCBM |
pfam08305 |
NPCBM/NEW2 domain; This novel putative carbohydrate binding module (NPCBM) domain is found at ... |
1620-1761 |
1.51e-48 |
|
NPCBM/NEW2 domain; This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins. This domain has also been called the NEW2 domain (Naumoff DG. Phylogenetic analysis of alpha-galactosidases of the GH27 family. Molecular Biology (Engl Transl). (2004)38:388-399.)
Pssm-ID: 429907 Cd Length: 137 Bit Score: 169.66 E-value: 1.51e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 1620 ETYISDLSWKSATIGSGAIGKDISVRRETIQIRNedgsyQAYEKGIGTHAQSEIVYD-SADYDIFDTWVGLDRYVagESV 1698
Cdd:pfam08305 2 EVYLSDLPWLSATNGWGPVERDRSNDGNPLTIGG-----VTYAKGLGTHAPSELTYDlGGKCTRFTAVVGVDDEV--GGK 74
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 494496751 1699 ASVNFKIYVDGVLKAETGIMKADTPKKRLVVDVRGSKQIKLVADQATNGNNWDHADWADAKFR 1761
Cdd:pfam08305 75 GSVRFEVYGDGKELYTSGVLTGGDPAVAVDVDVTGAKRLRLVVTDGGDGNNYDHADWADAKLT 137
|
|
| NPCBM |
pfam08305 |
NPCBM/NEW2 domain; This novel putative carbohydrate binding module (NPCBM) domain is found at ... |
880-1019 |
1.41e-45 |
|
NPCBM/NEW2 domain; This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins. This domain has also been called the NEW2 domain (Naumoff DG. Phylogenetic analysis of alpha-galactosidases of the GH27 family. Molecular Biology (Engl Transl). (2004)38:388-399.)
Pssm-ID: 429907 Cd Length: 137 Bit Score: 161.19 E-value: 1.41e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 880 DYDYLSDFKWESATTVWGTPRRNSNIQGR---VNGQTerFEKGFGIHANGKITYDLsDKQYDRFEALLGVDPSAidpNNN 956
Cdd:pfam08305 1 GEVYLSDLPWLSATNGWGPVERDRSNDGNpltIGGVT--YAKGLGTHAPSELTYDL-GGKCTRFTAVVGVDDEV---GGK 74
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 494496751 957 SSVKFKIIADGKTLTSTNVLGYYDNMVYVNVPVSGVKKLVIEVSDAENGNTADHCIIVNPKLT 1019
Cdd:pfam08305 75 GSVRFEVYGDGKELYTSGVLTGGDPAVAVDVDVTGAKRLRLVVTDGGDGNNYDHADWADAKLT 137
|
|
| NPCBM |
pfam08305 |
NPCBM/NEW2 domain; This novel putative carbohydrate binding module (NPCBM) domain is found at ... |
1396-1537 |
2.20e-45 |
|
NPCBM/NEW2 domain; This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins. This domain has also been called the NEW2 domain (Naumoff DG. Phylogenetic analysis of alpha-galactosidases of the GH27 family. Molecular Biology (Engl Transl). (2004)38:388-399.)
Pssm-ID: 429907 Cd Length: 137 Bit Score: 160.42 E-value: 2.20e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 1396 KSTYLSDMNWESAKTGWRTVTKDTAVgssDKIKLNVDGKvkTFDKGIGAATNAEIVYNLDGNYNYFTTYLGTDKNYDMDS 1475
Cdd:pfam08305 1 GEVYLSDLPWLSATNGWGPVERDRSN---DGNPLTIGGV--TYAKGLGTHAPSELTYDLGGKCTRFTAVVGVDDEVGGKG 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 494496751 1476 TtIRFRILADGKEVYTSDVIRKNTPAEFVNLDVTGVKKLVLVADDVDGNLVGDFASWADTKV 1537
Cdd:pfam08305 76 S-VRFEVYGDGKELYTSGVLTGGDPAVAVDVDVTGAKRLRLVVTDGGDGNNYDHADWADAKL 136
|
|
| NPCBM |
smart00776 |
This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of ... |
1620-1761 |
9.36e-41 |
|
This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins;
Pssm-ID: 214816 Cd Length: 145 Bit Score: 147.51 E-value: 9.36e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 1620 ETYISDLSWKSATIGSGAIGKDISV------RRETIQIRNedgsyQAYEKGIGTHAQSEIVYDSA-DYDIFDTWVGLDRY 1692
Cdd:smart00776 4 DVYLSDLGWKSATNGWGPVEKNRSNgesnagDGRPLTLGG-----QTYAKGIGTHAPSEIVYDLGgGCDTFTALVGVDDE 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 494496751 1693 VAgeSVASVNFKIYVDGVLKAETGIMKADTPKKRLVVDVRGSKQIKLVADQATNGNNWDHADWADAKFR 1761
Cdd:smart00776 79 VG--NRGSVVFEVYADGTKLYNSGVLRGADPAKAVDVDVSGAKELRLVVTDAGDGISYDHADWADAKLT 145
|
|
| NPCBM |
smart00776 |
This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of ... |
1395-1537 |
9.89e-36 |
|
This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins;
Pssm-ID: 214816 Cd Length: 145 Bit Score: 133.26 E-value: 9.89e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 1395 SKSTYLSDMNWESAKTGWRTVTKDTAVGSS---DKIKLNVDGKvkTFDKGIGAATNAEIVYNLDGNYNYFTTYLGTDKNy 1471
Cdd:smart00776 2 SGDVYLSDLGWKSATNGWGPVEKNRSNGESnagDGRPLTLGGQ--TYAKGIGTHAPSEIVYDLGGGCDTFTALVGVDDE- 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 494496751 1472 DMDSTTIRFRILADGKEVYTSDVIRKNTPAEFVNLDVTGVKKLVLVADDVDGNLVGDFASWADTKV 1537
Cdd:smart00776 79 VGNRGSVVFEVYADGTKLYNSGVLRGADPAKAVDVDVSGAKELRLVVTDAGDGISYDHADWADAKL 144
|
|
| NPCBM |
smart00776 |
This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of ... |
883-1019 |
1.09e-32 |
|
This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins;
Pssm-ID: 214816 Cd Length: 145 Bit Score: 124.79 E-value: 1.09e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 883 YLSDFKWESATTVWGTPRRNSNI------QGR---VNGQTerFEKGFGIHANGKITYDLsDKQYDRFEALLGVDpsaiDP 953
Cdd:smart00776 6 YLSDLGWKSATNGWGPVEKNRSNgesnagDGRpltLGGQT--YAKGIGTHAPSEIVYDL-GGGCDTFTALVGVD----DE 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 494496751 954 N-NNSSVKFKIIADGKTLTSTNVLGYYDNMVYVNVPVSGVKKLVIEVSDAENGNTADHCIIVNPKLT 1019
Cdd:smart00776 79 VgNRGSVVFEVYADGTKLYNSGVLRGADPAKAVDVDVSGAKELRLVVTDAGDGISYDHADWADAKLT 145
|
|
| Peptidase_M60 |
pfam13402 |
Peptidase M60, enhancin and enhancin-like; This family of peptidases contains a zinc ... |
416-682 |
9.66e-16 |
|
Peptidase M60, enhancin and enhancin-like; This family of peptidases contains a zinc metallopeptidase motif (HEXXHX(8,28)E) and possesses mucinase activity. It includes the viral enhancins as well as enhancin-like peptidases from bacterial species. Enhancins are a class of metalloproteases found in some baculoviruses that enhance viral infection by degrading the peritrophic membrane (PM) of the insect midgut. Bacterial enhancins are found to be cytotoxic when compared to viral enhancin, however, suggesting that the bacterial enhancins do not enhance infection in the same way as viral enhancin. Bacterial enhancins may have evolved a distinct biochemical function. These bacterial domains are peptidases targetting host glycoproteins and thus probably play an important role in successful colonization of both vertebrate mucosal surfaces and the invertebrate digestive tract by both mutualistic and pathogenic microbes. This family has been augmented by a merge with the sequences in the Enhancin Pfam family.
Pssm-ID: 433178 [Multi-domain] Cd Length: 268 Bit Score: 79.35 E-value: 9.66e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 416 GGEEFPLYNEGDDKDAfleklkAYKEKLDKNPDTtvdIFEFNTKRLLYTGTAKAAYQvyvKEGVDVGESIQVWnDKIQEA 495
Cdd:pfam13402 1 GAVRAPYFVYGKTTDE------EWEEMLRNYPAP---WAELDGGRVILTVPSEFLRQ---LDRLNPQALWRLW-DRVMYS 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 496 FD-FAGLKDDPSDPTndSTNVRTTIRLMQPYGAAYAAYGHVGIQRGIQEIALRTDkDSINSILWGMVHEVGHQMDIS--- 571
Cdd:pfam13402 68 VNeVAGLPRRSDGRV--TRPVRFVFDRQISAGFMHAGYPIMAFPPGSASELVNYD-SARKSGCWGPLHELGHNFQQRwgw 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 572 --EREWGEITNNMFanNAYINNGAGDrvPYSQIQTSLAPDD-ASTNFDNLDYSQR-----------LGMFWQL--HLKDN 635
Cdd:pfam13402 145 twPGHTGEVTNNIL--SLYVQELLTG--IDSTRQINFNGRArWGPALGGWARDKHakeylnkgkdlLVFYGQLlyYFGWD 220
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 494496751 636 TYwAEVEKLYRKRKPSVSN--EQAKRDTFAKYASEVLNMNLTKHFEKYG 682
Cdd:pfam13402 221 FY-RKLFRAYRTQPYLPRNnsDGDKMSEFMLTFSKVAKRDLRPFFKAWG 268
|
|
| DUF5011 |
pfam16403 |
Domain of unknown function (DUF5011); This entry represents a bacterial immunoglobulin-like ... |
1321-1393 |
7.36e-13 |
|
Domain of unknown function (DUF5011); This entry represents a bacterial immunoglobulin-like domain.
Pssm-ID: 435320 [Multi-domain] Cd Length: 71 Bit Score: 65.26 E-value: 7.36e-13
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 494496751 1321 TLKFEEFTMVKKNSEFNLMdGVVADDKeDGDITNKVVVDnGGFNPNKVGTYTVTYTITDKDSNITTKQRTIVV 1393
Cdd:pfam16403 2 TLNGDNDITIELGTTYEDP-GATATDN-DGDLTDKVKVT-GSVDTSKPGTYTLTYTVTDSDGNSATVTRTVTV 71
|
|
| F5_F8_type_C |
pfam00754 |
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family. |
1124-1254 |
5.52e-12 |
|
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
Pssm-ID: 459925 [Multi-domain] Cd Length: 127 Bit Score: 64.78 E-value: 5.52e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 1124 PIKSVKNNAGNYqssVITNAIDGKINTHWetdSPNNNSFKNEVTFDLGEVQEISKIAYASRRDGNfKGFATQFEIYVSES 1203
Cdd:pfam00754 1 QITASSSYSGEG---PAAAALDGDPNTAW---SAWSGDDPQWIQVDLGKPKKITGVVTQGRQDGS-NGYVTSYKIEYSLD 73
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 494496751 1204 ESGDDFYLAG--QGSYSGAISDVVEFNVSkVKARRVKFKFVQA--SGDWASFSEV 1254
Cdd:pfam00754 74 GENWTTVKDEkiPGNNDNNTPVTNTFDPP-IKARYVRIVPTSWngGNGIALRAEL 127
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
1849-1973 |
4.91e-09 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 60.72 E-value: 4.91e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 1849 KQLNLSG-QIT-----VGDMRKLVSLNLS--QVESLEGLQYAINLQSLNIQYNEIRDLSPLKNLKKLT--DLKANPIGGL 1918
Cdd:COG4886 208 EELDLSGnQLTdlpepLANLTNLETLDLSnnQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKtlDLSNNQLTDL 287
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 494496751 1919 MSTNIrpQNNKATINFDFINREGKKLAPTLITLKNNKTQEVKQLNVGECVDENGL 1973
Cdd:COG4886 288 KLKEL--ELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTL 340
|
|
| DUF5011 |
pfam16403 |
Domain of unknown function (DUF5011); This entry represents a bacterial immunoglobulin-like ... |
1029-1097 |
4.99e-09 |
|
Domain of unknown function (DUF5011); This entry represents a bacterial immunoglobulin-like domain.
Pssm-ID: 435320 [Multi-domain] Cd Length: 71 Bit Score: 54.48 E-value: 4.99e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 494496751 1029 AEDKYIKLGQDFdVREGVKAHDQeDGDLTAQIQVESNTFVkDKIGKYEVVYKVADKDGNETTKKINVTV 1097
Cdd:pfam16403 6 DNDITIELGTTY-EDPGATATDN-DGDLTDKVKVTGSVDT-SKPGTYTLTYTVTDSDGNSATVTRTVTV 71
|
|
| F5_F8_type_C |
pfam00754 |
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family. |
115-225 |
2.17e-07 |
|
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
Pssm-ID: 459925 [Multi-domain] Cd Length: 127 Bit Score: 51.68 E-value: 2.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 115 KAFDDEVETYWASSklnSDTFKNEIVVTLKESTKIDTMIYGGTPHWQKGYAEQFEIYASNtdEGDDFRLIATGEQPANHD 194
Cdd:pfam00754 16 AALDGDPNTAWSAW---SGDDPQWIQVDLGKPKKITGVVTQGRQDGSNGYVTSYKIEYSL--DGENWTTVKDEKIPGNND 90
|
90 100 110
....*....|....*....|....*....|....*
gi 494496751 195 ---IKEINF-TPTKLKRLKFVFKKGNLNQAACSVF 225
Cdd:pfam00754 91 nntPVTNTFdPPIKARYVRIVPTSWNGGNGIALRA 125
|
|
| DUF5011 |
pfam16403 |
Domain of unknown function (DUF5011); This entry represents a bacterial immunoglobulin-like ... |
1546-1614 |
5.22e-07 |
|
Domain of unknown function (DUF5011); This entry represents a bacterial immunoglobulin-like domain.
Pssm-ID: 435320 [Multi-domain] Cd Length: 71 Bit Score: 48.70 E-value: 5.22e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 494496751 1546 IKGDDVVVFDVKEKVDLlQGITATDfEDGDITSCIQIETDYTQGKAGVFEVVYSVTDNDGFTTKFTRKV 1614
Cdd:pfam16403 3 LNGDNDITIELGTTYED-PGATATD-NDGDLTDKVKVTGSVDTSKPGTYTLTYTVTDSDGNSATVTRTV 69
|
|
| M60-like_N |
pfam17291 |
N-terminal domain of M60-like peptidases; This accessory domain has a jelly roll topology. |
293-414 |
1.97e-05 |
|
N-terminal domain of M60-like peptidases; This accessory domain has a jelly roll topology.
Pssm-ID: 435844 [Multi-domain] Cd Length: 106 Bit Score: 45.41 E-value: 1.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 293 TDRTFTLTQNGHThsksrnvlrmsrlgTDLQSTGIVARPGQVFKIFVEADSNTKLpQIVFTQQEGHFSH---W------Q 363
Cdd:pfam17291 4 TREKARVRINSRY--------------SDWQSTGLYAPPGELITIEVPDNAVGKL-VVQIGCHTDNLGHadeLfrppvvT 68
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 494496751 364 KEYQLKKGLNVITVPeiysdswsqksvKGGAVYLmnRYTADEQGKAPVVRI 414
Cdd:pfam17291 69 CRFPLDEGVNKISWP------------YGGLIYI--IVPIDTFEGAVEVTI 105
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
1865-1915 |
1.34e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 42.47 E-value: 1.34e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 494496751 1865 LVSLNLS--QVESLEGLQYAINLQSLNIQYNEIRDLS----PLKNLKKLT--DLKANPI 1915
Cdd:cd21340 122 LRVLNISgnNIDSLEPLAPLRNLEQLDASNNQISDLEelldLLSSWPSLRelDLTGNPV 180
|
|
| LRR_4 |
pfam12799 |
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
1884-1910 |
1.98e-03 |
|
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.
Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 37.61 E-value: 1.98e-03
10 20
....*....|....*....|....*..
gi 494496751 1884 NLQSLNIQYNEIRDLSPLKNLKKLTDL 1910
Cdd:pfam12799 2 NLEVLDLSNNQITDIPPLAKLPNLETL 28
|
|
| COG3291 |
COG3291 |
Uncharacterized conserved protein, PKD repeat domain [Function unknown]; |
1366-1608 |
2.00e-03 |
|
Uncharacterized conserved protein, PKD repeat domain [Function unknown];
Pssm-ID: 442520 [Multi-domain] Cd Length: 333 Bit Score: 42.73 E-value: 2.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 1366 NKVGTYTVTYTITDKDSNITTKQRTIVVYSKSTYLSDMNWESAKTGWRTVTKDTAVGSSDKIKLNVDGKVKTFDKGIGAA 1445
Cdd:COG3291 47 TTPGTYTVTLTVTDAAGCSDTTTKTITVGAPNPGVTTVTTSTTVTTLANTANGGATTVVAGSTVGTGVATSTTTAAAPGG 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 1446 TNAEIVYNLDGNYNYFTTYLGTDKNYDMDSTTIRFRILADGKEVYTSDVIRKNTPAEFVNLDVTGVKKLVLVADDVDGNL 1525
Cdd:COG3291 127 GGGTGTTTTTGTDTGLTGSTGTASDTATVTTSVSTTDVTSDGTTSASTNPSVTTDTVTTLTGSYTGTIVGGSGSGTVTSG 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 1526 VGDFASWADTKVYQYNSKPVIKGDDVVVFDVKEKVDLLQGITATDFEDGDITSCIQIETDYTQGKAGVFEVVYSVTDNDG 1605
Cdd:COG3291 207 TAGVTTGATSGTSGTGSATSGVAVTDVTLTGISTGDAGTPGTNTVTTSGANTAGTSTITGGTSGVVTTSAATGTSTNGTG 286
|
...
gi 494496751 1606 FTT 1608
Cdd:COG3291 287 GLG 289
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| NPCBM |
pfam08305 |
NPCBM/NEW2 domain; This novel putative carbohydrate binding module (NPCBM) domain is found at ... |
1620-1761 |
1.51e-48 |
|
NPCBM/NEW2 domain; This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins. This domain has also been called the NEW2 domain (Naumoff DG. Phylogenetic analysis of alpha-galactosidases of the GH27 family. Molecular Biology (Engl Transl). (2004)38:388-399.)
Pssm-ID: 429907 Cd Length: 137 Bit Score: 169.66 E-value: 1.51e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 1620 ETYISDLSWKSATIGSGAIGKDISVRRETIQIRNedgsyQAYEKGIGTHAQSEIVYD-SADYDIFDTWVGLDRYVagESV 1698
Cdd:pfam08305 2 EVYLSDLPWLSATNGWGPVERDRSNDGNPLTIGG-----VTYAKGLGTHAPSELTYDlGGKCTRFTAVVGVDDEV--GGK 74
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 494496751 1699 ASVNFKIYVDGVLKAETGIMKADTPKKRLVVDVRGSKQIKLVADQATNGNNWDHADWADAKFR 1761
Cdd:pfam08305 75 GSVRFEVYGDGKELYTSGVLTGGDPAVAVDVDVTGAKRLRLVVTDGGDGNNYDHADWADAKLT 137
|
|
| NPCBM |
pfam08305 |
NPCBM/NEW2 domain; This novel putative carbohydrate binding module (NPCBM) domain is found at ... |
880-1019 |
1.41e-45 |
|
NPCBM/NEW2 domain; This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins. This domain has also been called the NEW2 domain (Naumoff DG. Phylogenetic analysis of alpha-galactosidases of the GH27 family. Molecular Biology (Engl Transl). (2004)38:388-399.)
Pssm-ID: 429907 Cd Length: 137 Bit Score: 161.19 E-value: 1.41e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 880 DYDYLSDFKWESATTVWGTPRRNSNIQGR---VNGQTerFEKGFGIHANGKITYDLsDKQYDRFEALLGVDPSAidpNNN 956
Cdd:pfam08305 1 GEVYLSDLPWLSATNGWGPVERDRSNDGNpltIGGVT--YAKGLGTHAPSELTYDL-GGKCTRFTAVVGVDDEV---GGK 74
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 494496751 957 SSVKFKIIADGKTLTSTNVLGYYDNMVYVNVPVSGVKKLVIEVSDAENGNTADHCIIVNPKLT 1019
Cdd:pfam08305 75 GSVRFEVYGDGKELYTSGVLTGGDPAVAVDVDVTGAKRLRLVVTDGGDGNNYDHADWADAKLT 137
|
|
| NPCBM |
pfam08305 |
NPCBM/NEW2 domain; This novel putative carbohydrate binding module (NPCBM) domain is found at ... |
1396-1537 |
2.20e-45 |
|
NPCBM/NEW2 domain; This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins. This domain has also been called the NEW2 domain (Naumoff DG. Phylogenetic analysis of alpha-galactosidases of the GH27 family. Molecular Biology (Engl Transl). (2004)38:388-399.)
Pssm-ID: 429907 Cd Length: 137 Bit Score: 160.42 E-value: 2.20e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 1396 KSTYLSDMNWESAKTGWRTVTKDTAVgssDKIKLNVDGKvkTFDKGIGAATNAEIVYNLDGNYNYFTTYLGTDKNYDMDS 1475
Cdd:pfam08305 1 GEVYLSDLPWLSATNGWGPVERDRSN---DGNPLTIGGV--TYAKGLGTHAPSELTYDLGGKCTRFTAVVGVDDEVGGKG 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 494496751 1476 TtIRFRILADGKEVYTSDVIRKNTPAEFVNLDVTGVKKLVLVADDVDGNLVGDFASWADTKV 1537
Cdd:pfam08305 76 S-VRFEVYGDGKELYTSGVLTGGDPAVAVDVDVTGAKRLRLVVTDGGDGNNYDHADWADAKL 136
|
|
| NPCBM |
smart00776 |
This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of ... |
1620-1761 |
9.36e-41 |
|
This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins;
Pssm-ID: 214816 Cd Length: 145 Bit Score: 147.51 E-value: 9.36e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 1620 ETYISDLSWKSATIGSGAIGKDISV------RRETIQIRNedgsyQAYEKGIGTHAQSEIVYDSA-DYDIFDTWVGLDRY 1692
Cdd:smart00776 4 DVYLSDLGWKSATNGWGPVEKNRSNgesnagDGRPLTLGG-----QTYAKGIGTHAPSEIVYDLGgGCDTFTALVGVDDE 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 494496751 1693 VAgeSVASVNFKIYVDGVLKAETGIMKADTPKKRLVVDVRGSKQIKLVADQATNGNNWDHADWADAKFR 1761
Cdd:smart00776 79 VG--NRGSVVFEVYADGTKLYNSGVLRGADPAKAVDVDVSGAKELRLVVTDAGDGISYDHADWADAKLT 145
|
|
| NPCBM |
smart00776 |
This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of ... |
1395-1537 |
9.89e-36 |
|
This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins;
Pssm-ID: 214816 Cd Length: 145 Bit Score: 133.26 E-value: 9.89e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 1395 SKSTYLSDMNWESAKTGWRTVTKDTAVGSS---DKIKLNVDGKvkTFDKGIGAATNAEIVYNLDGNYNYFTTYLGTDKNy 1471
Cdd:smart00776 2 SGDVYLSDLGWKSATNGWGPVEKNRSNGESnagDGRPLTLGGQ--TYAKGIGTHAPSEIVYDLGGGCDTFTALVGVDDE- 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 494496751 1472 DMDSTTIRFRILADGKEVYTSDVIRKNTPAEFVNLDVTGVKKLVLVADDVDGNLVGDFASWADTKV 1537
Cdd:smart00776 79 VGNRGSVVFEVYADGTKLYNSGVLRGADPAKAVDVDVSGAKELRLVVTDAGDGISYDHADWADAKL 144
|
|
| NPCBM |
smart00776 |
This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of ... |
883-1019 |
1.09e-32 |
|
This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins;
Pssm-ID: 214816 Cd Length: 145 Bit Score: 124.79 E-value: 1.09e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 883 YLSDFKWESATTVWGTPRRNSNI------QGR---VNGQTerFEKGFGIHANGKITYDLsDKQYDRFEALLGVDpsaiDP 953
Cdd:smart00776 6 YLSDLGWKSATNGWGPVEKNRSNgesnagDGRpltLGGQT--YAKGIGTHAPSEIVYDL-GGGCDTFTALVGVD----DE 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 494496751 954 N-NNSSVKFKIIADGKTLTSTNVLGYYDNMVYVNVPVSGVKKLVIEVSDAENGNTADHCIIVNPKLT 1019
Cdd:smart00776 79 VgNRGSVVFEVYADGTKLYNSGVLRGADPAKAVDVDVSGAKELRLVVTDAGDGISYDHADWADAKLT 145
|
|
| Peptidase_M60 |
pfam13402 |
Peptidase M60, enhancin and enhancin-like; This family of peptidases contains a zinc ... |
416-682 |
9.66e-16 |
|
Peptidase M60, enhancin and enhancin-like; This family of peptidases contains a zinc metallopeptidase motif (HEXXHX(8,28)E) and possesses mucinase activity. It includes the viral enhancins as well as enhancin-like peptidases from bacterial species. Enhancins are a class of metalloproteases found in some baculoviruses that enhance viral infection by degrading the peritrophic membrane (PM) of the insect midgut. Bacterial enhancins are found to be cytotoxic when compared to viral enhancin, however, suggesting that the bacterial enhancins do not enhance infection in the same way as viral enhancin. Bacterial enhancins may have evolved a distinct biochemical function. These bacterial domains are peptidases targetting host glycoproteins and thus probably play an important role in successful colonization of both vertebrate mucosal surfaces and the invertebrate digestive tract by both mutualistic and pathogenic microbes. This family has been augmented by a merge with the sequences in the Enhancin Pfam family.
Pssm-ID: 433178 [Multi-domain] Cd Length: 268 Bit Score: 79.35 E-value: 9.66e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 416 GGEEFPLYNEGDDKDAfleklkAYKEKLDKNPDTtvdIFEFNTKRLLYTGTAKAAYQvyvKEGVDVGESIQVWnDKIQEA 495
Cdd:pfam13402 1 GAVRAPYFVYGKTTDE------EWEEMLRNYPAP---WAELDGGRVILTVPSEFLRQ---LDRLNPQALWRLW-DRVMYS 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 496 FD-FAGLKDDPSDPTndSTNVRTTIRLMQPYGAAYAAYGHVGIQRGIQEIALRTDkDSINSILWGMVHEVGHQMDIS--- 571
Cdd:pfam13402 68 VNeVAGLPRRSDGRV--TRPVRFVFDRQISAGFMHAGYPIMAFPPGSASELVNYD-SARKSGCWGPLHELGHNFQQRwgw 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 572 --EREWGEITNNMFanNAYINNGAGDrvPYSQIQTSLAPDD-ASTNFDNLDYSQR-----------LGMFWQL--HLKDN 635
Cdd:pfam13402 145 twPGHTGEVTNNIL--SLYVQELLTG--IDSTRQINFNGRArWGPALGGWARDKHakeylnkgkdlLVFYGQLlyYFGWD 220
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 494496751 636 TYwAEVEKLYRKRKPSVSN--EQAKRDTFAKYASEVLNMNLTKHFEKYG 682
Cdd:pfam13402 221 FY-RKLFRAYRTQPYLPRNnsDGDKMSEFMLTFSKVAKRDLRPFFKAWG 268
|
|
| DUF5011 |
pfam16403 |
Domain of unknown function (DUF5011); This entry represents a bacterial immunoglobulin-like ... |
1321-1393 |
7.36e-13 |
|
Domain of unknown function (DUF5011); This entry represents a bacterial immunoglobulin-like domain.
Pssm-ID: 435320 [Multi-domain] Cd Length: 71 Bit Score: 65.26 E-value: 7.36e-13
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 494496751 1321 TLKFEEFTMVKKNSEFNLMdGVVADDKeDGDITNKVVVDnGGFNPNKVGTYTVTYTITDKDSNITTKQRTIVV 1393
Cdd:pfam16403 2 TLNGDNDITIELGTTYEDP-GATATDN-DGDLTDKVKVT-GSVDTSKPGTYTLTYTVTDSDGNSATVTRTVTV 71
|
|
| F5_F8_type_C |
pfam00754 |
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family. |
1124-1254 |
5.52e-12 |
|
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
Pssm-ID: 459925 [Multi-domain] Cd Length: 127 Bit Score: 64.78 E-value: 5.52e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 1124 PIKSVKNNAGNYqssVITNAIDGKINTHWetdSPNNNSFKNEVTFDLGEVQEISKIAYASRRDGNfKGFATQFEIYVSES 1203
Cdd:pfam00754 1 QITASSSYSGEG---PAAAALDGDPNTAW---SAWSGDDPQWIQVDLGKPKKITGVVTQGRQDGS-NGYVTSYKIEYSLD 73
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 494496751 1204 ESGDDFYLAG--QGSYSGAISDVVEFNVSkVKARRVKFKFVQA--SGDWASFSEV 1254
Cdd:pfam00754 74 GENWTTVKDEkiPGNNDNNTPVTNTFDPP-IKARYVRIVPTSWngGNGIALRAEL 127
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
1849-1973 |
4.91e-09 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 60.72 E-value: 4.91e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 1849 KQLNLSG-QIT-----VGDMRKLVSLNLS--QVESLEGLQYAINLQSLNIQYNEIRDLSPLKNLKKLT--DLKANPIGGL 1918
Cdd:COG4886 208 EELDLSGnQLTdlpepLANLTNLETLDLSnnQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKtlDLSNNQLTDL 287
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 494496751 1919 MSTNIrpQNNKATINFDFINREGKKLAPTLITLKNNKTQEVKQLNVGECVDENGL 1973
Cdd:COG4886 288 KLKEL--ELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTL 340
|
|
| DUF5011 |
pfam16403 |
Domain of unknown function (DUF5011); This entry represents a bacterial immunoglobulin-like ... |
1029-1097 |
4.99e-09 |
|
Domain of unknown function (DUF5011); This entry represents a bacterial immunoglobulin-like domain.
Pssm-ID: 435320 [Multi-domain] Cd Length: 71 Bit Score: 54.48 E-value: 4.99e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 494496751 1029 AEDKYIKLGQDFdVREGVKAHDQeDGDLTAQIQVESNTFVkDKIGKYEVVYKVADKDGNETTKKINVTV 1097
Cdd:pfam16403 6 DNDITIELGTTY-EDPGATATDN-DGDLTDKVKVTGSVDT-SKPGTYTLTYTVTDSDGNSATVTRTVTV 71
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
1754-1918 |
6.47e-08 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 57.25 E-value: 6.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 1754 DWADAKFRNVPEFNTAELEKLLEEAKELDLNNYTEESIEALENAIQTGEEAMTSENQETVDKAVEQLRNAMNSLVEANLN 1833
Cdd:COG4886 3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 1834 QVVKIQDEYLRKAIQ-KQLNLSGQITVGDMRKLVSLNLS--QVESL-EGLQYAINLQSLNIQYNEIRDL-SPLKNLKKLT 1908
Cdd:COG4886 83 SLLLLGLTDLGDLTNlTELDLSGNEELSNLTNLESLDLSgnQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLK 162
|
170
....*....|..
gi 494496751 1909 --DLKANPIGGL 1918
Cdd:COG4886 163 slDLSNNQLTDL 174
|
|
| F5_F8_type_C |
pfam00754 |
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family. |
115-225 |
2.17e-07 |
|
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
Pssm-ID: 459925 [Multi-domain] Cd Length: 127 Bit Score: 51.68 E-value: 2.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 115 KAFDDEVETYWASSklnSDTFKNEIVVTLKESTKIDTMIYGGTPHWQKGYAEQFEIYASNtdEGDDFRLIATGEQPANHD 194
Cdd:pfam00754 16 AALDGDPNTAWSAW---SGDDPQWIQVDLGKPKKITGVVTQGRQDGSNGYVTSYKIEYSL--DGENWTTVKDEKIPGNND 90
|
90 100 110
....*....|....*....|....*....|....*
gi 494496751 195 ---IKEINF-TPTKLKRLKFVFKKGNLNQAACSVF 225
Cdd:pfam00754 91 nntPVTNTFdPPIKARYVRIVPTSWNGGNGIALRA 125
|
|
| DUF5011 |
pfam16403 |
Domain of unknown function (DUF5011); This entry represents a bacterial immunoglobulin-like ... |
1546-1614 |
5.22e-07 |
|
Domain of unknown function (DUF5011); This entry represents a bacterial immunoglobulin-like domain.
Pssm-ID: 435320 [Multi-domain] Cd Length: 71 Bit Score: 48.70 E-value: 5.22e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 494496751 1546 IKGDDVVVFDVKEKVDLlQGITATDfEDGDITSCIQIETDYTQGKAGVFEVVYSVTDNDGFTTKFTRKV 1614
Cdd:pfam16403 3 LNGDNDITIELGTTYED-PGATATD-NDGDLTDKVKVTGSVDTSKPGTYTLTYTVTDSDGNSATVTRTV 69
|
|
| M60-like_N |
pfam17291 |
N-terminal domain of M60-like peptidases; This accessory domain has a jelly roll topology. |
293-414 |
1.97e-05 |
|
N-terminal domain of M60-like peptidases; This accessory domain has a jelly roll topology.
Pssm-ID: 435844 [Multi-domain] Cd Length: 106 Bit Score: 45.41 E-value: 1.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 293 TDRTFTLTQNGHThsksrnvlrmsrlgTDLQSTGIVARPGQVFKIFVEADSNTKLpQIVFTQQEGHFSH---W------Q 363
Cdd:pfam17291 4 TREKARVRINSRY--------------SDWQSTGLYAPPGELITIEVPDNAVGKL-VVQIGCHTDNLGHadeLfrppvvT 68
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 494496751 364 KEYQLKKGLNVITVPeiysdswsqksvKGGAVYLmnRYTADEQGKAPVVRI 414
Cdd:pfam17291 69 CRFPLDEGVNKISWP------------YGGLIYI--IVPIDTFEGAVEVTI 105
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
1849-1915 |
2.74e-05 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 48.78 E-value: 2.74e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 494496751 1849 KQLNLSG-QIT-----VGDMRKLVSLNLS--QVESL-EGLQYAINLQSLNIQYNEIRDLS-PLKNLKKLT--DLKANPI 1915
Cdd:COG4886 116 ESLDLSGnQLTdlpeeLANLTNLKELDLSnnQLTDLpEPLGNLTNLKSLDLSNNQLTDLPeELGNLTNLKelDLSNNQI 194
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
1865-1915 |
1.34e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 42.47 E-value: 1.34e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 494496751 1865 LVSLNLS--QVESLEGLQYAINLQSLNIQYNEIRDLS----PLKNLKKLT--DLKANPI 1915
Cdd:cd21340 122 LRVLNISgnNIDSLEPLAPLRNLEQLDASNNQISDLEelldLLSSWPSLRelDLTGNPV 180
|
|
| LRR_4 |
pfam12799 |
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
1884-1910 |
1.98e-03 |
|
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.
Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 37.61 E-value: 1.98e-03
10 20
....*....|....*....|....*..
gi 494496751 1884 NLQSLNIQYNEIRDLSPLKNLKKLTDL 1910
Cdd:pfam12799 2 NLEVLDLSNNQITDIPPLAKLPNLETL 28
|
|
| COG3291 |
COG3291 |
Uncharacterized conserved protein, PKD repeat domain [Function unknown]; |
1366-1608 |
2.00e-03 |
|
Uncharacterized conserved protein, PKD repeat domain [Function unknown];
Pssm-ID: 442520 [Multi-domain] Cd Length: 333 Bit Score: 42.73 E-value: 2.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 1366 NKVGTYTVTYTITDKDSNITTKQRTIVVYSKSTYLSDMNWESAKTGWRTVTKDTAVGSSDKIKLNVDGKVKTFDKGIGAA 1445
Cdd:COG3291 47 TTPGTYTVTLTVTDAAGCSDTTTKTITVGAPNPGVTTVTTSTTVTTLANTANGGATTVVAGSTVGTGVATSTTTAAAPGG 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 1446 TNAEIVYNLDGNYNYFTTYLGTDKNYDMDSTTIRFRILADGKEVYTSDVIRKNTPAEFVNLDVTGVKKLVLVADDVDGNL 1525
Cdd:COG3291 127 GGGTGTTTTTGTDTGLTGSTGTASDTATVTTSVSTTDVTSDGTTSASTNPSVTTDTVTTLTGSYTGTIVGGSGSGTVTSG 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 1526 VGDFASWADTKVYQYNSKPVIKGDDVVVFDVKEKVDLLQGITATDFEDGDITSCIQIETDYTQGKAGVFEVVYSVTDNDG 1605
Cdd:COG3291 207 TAGVTTGATSGTSGTGSATSGVAVTDVTLTGISTGDAGTPGTNTVTTSGANTAGTSTITGGTSGVVTTSAATGTSTNGTG 286
|
...
gi 494496751 1606 FTT 1608
Cdd:COG3291 287 GLG 289
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
1849-1978 |
6.03e-03 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 41.46 E-value: 6.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494496751 1849 KQLNLSG-QIT----VGDMRKLVSLNLS--QVESLEGLQYAINLQSLNIQYNEIRDLSpLKNLKKLTDLKANPIGGLMST 1921
Cdd:COG4886 231 ETLDLSNnQLTdlpeLGNLTNLEELDLSnnQLTDLPPLANLTNLKTLDLSNNQLTDLK-LKELELLLGLNSLLLLLLLLN 309
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 494496751 1922 NIRPQNNKATINFDFINREGKKLAPTLITLKNNKTQEVKQLNVGECVDENGLVTIDT 1978
Cdd:COG4886 310 LLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLL 366
|
|
| |
