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Conserved domains on  [gi|494493634|ref|WP_007283103|]
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CHAP domain-containing protein [Gluconobacter thailandicus]

Protein Classification

CHAP domain-containing protein( domain architecture ID 11467641)

cysteine, histidine-dependent amidohydrolase/peptidase (CHAP) domain-containing protein may function as an amidase involved in the cleavage of peptidoglycan

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3942 COG3942
Surface antigen [Cell wall/membrane/envelope biogenesis];
22-119 1.45e-18

Surface antigen [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 443142 [Multi-domain]  Cd Length: 129  Bit Score: 76.18  E-value: 1.45e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494493634  22 SRASFNGPLQCAPYARSRTGLQ------LSGAAASWWRQSAGH-YARSHSPTPGSVLVFRATSRVPSGHVSIVRKQISSR 94
Cdd:COG3942   16 DPWNGYPYGQCTWYAAWRRAQLggpigsGWGNANNWADNARAAgYTVGSTPKVGAVAVFTPGVAGPYGHVAVVESVNSDG 95

                         90       100
                 ....*....|....*....|....*..
gi 494493634  95 TILVDHANWE-PGRID-RNVPVTDVSP 119
Cdd:COG3942   96 SILVSEMNWGgPGIYStRTISAGNASS 122
 
Name Accession Description Interval E-value
COG3942 COG3942
Surface antigen [Cell wall/membrane/envelope biogenesis];
22-119 1.45e-18

Surface antigen [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443142 [Multi-domain]  Cd Length: 129  Bit Score: 76.18  E-value: 1.45e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494493634  22 SRASFNGPLQCAPYARSRTGLQ------LSGAAASWWRQSAGH-YARSHSPTPGSVLVFRATSRVPSGHVSIVRKQISSR 94
Cdd:COG3942   16 DPWNGYPYGQCTWYAAWRRAQLggpigsGWGNANNWADNARAAgYTVGSTPKVGAVAVFTPGVAGPYGHVAVVESVNSDG 95

                         90       100
                 ....*....|....*....|....*..
gi 494493634  95 TILVDHANWE-PGRID-RNVPVTDVSP 119
Cdd:COG3942   96 SILVSEMNWGgPGIYStRTISAGNASS 122
CHAP pfam05257
CHAP domain; This domain corresponds to an amidase function. Many of these proteins are ...
 31-102 1.21e-10

CHAP domain; This domain corresponds to an amidase function. Many of these proteins are involved in cell wall metabolism of bacteria. This domain is found at the N-terminus of Swiss:P43675, where it functions as a glutathionylspermidine amidase EC:3.5.1.78. This domain is found to be the catalytic domain of PlyCA. CHAP is the amidase domain of bifunctional Escherichia coli glutathionylspermidine synthetase/amidase, and it catalyzes the hydrolysis of Gsp (glutathionylspermidine) into glutathione and spermidine.


Pssm-ID: 461605 [Multi-domain]  Cd Length: 83  Bit Score: 54.74  E-value: 1.21e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 494493634   31 QCAPYA--RSRTGLQLSGAAASWWRQSAGHYARSHS-PTPGSVLVFRATSRVPS-GHVSIVRKqISSRTILVDHAN 102
Cdd:pfam05257   9 QCTWFVywRVAQLGIYLGNAGDWADAAAGAYKVGSTtPKVGDIVVFDPGGGGASyGHVAIVEK-VNDGSITVSEQN 83
 
Name Accession Description Interval E-value
COG3942 COG3942
Surface antigen [Cell wall/membrane/envelope biogenesis];
22-119 1.45e-18

Surface antigen [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443142 [Multi-domain]  Cd Length: 129  Bit Score: 76.18  E-value: 1.45e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 494493634  22 SRASFNGPLQCAPYARSRTGLQ------LSGAAASWWRQSAGH-YARSHSPTPGSVLVFRATSRVPSGHVSIVRKQISSR 94
Cdd:COG3942   16 DPWNGYPYGQCTWYAAWRRAQLggpigsGWGNANNWADNARAAgYTVGSTPKVGAVAVFTPGVAGPYGHVAVVESVNSDG 95

                         90       100
                 ....*....|....*....|....*..
gi 494493634  95 TILVDHANWE-PGRID-RNVPVTDVSP 119
Cdd:COG3942   96 SILVSEMNWGgPGIYStRTISAGNASS 122
CHAP pfam05257
CHAP domain; This domain corresponds to an amidase function. Many of these proteins are ...
 31-102 1.21e-10

CHAP domain; This domain corresponds to an amidase function. Many of these proteins are involved in cell wall metabolism of bacteria. This domain is found at the N-terminus of Swiss:P43675, where it functions as a glutathionylspermidine amidase EC:3.5.1.78. This domain is found to be the catalytic domain of PlyCA. CHAP is the amidase domain of bifunctional Escherichia coli glutathionylspermidine synthetase/amidase, and it catalyzes the hydrolysis of Gsp (glutathionylspermidine) into glutathione and spermidine.


Pssm-ID: 461605 [Multi-domain]  Cd Length: 83  Bit Score: 54.74  E-value: 1.21e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 494493634   31 QCAPYA--RSRTGLQLSGAAASWWRQSAGHYARSHS-PTPGSVLVFRATSRVPS-GHVSIVRKqISSRTILVDHAN 102
Cdd:pfam05257   9 QCTWFVywRVAQLGIYLGNAGDWADAAAGAYKVGSTtPKVGDIVVFDPGGGGASyGHVAIVEK-VNDGSITVSEQN 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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