|
Name |
Accession |
Description |
Interval |
E-value |
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
1-471 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 788.46 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 1 MRKTKIVCTLGPASDSEERIAQLISAGMNVARFNFSHGTHESHRATFERICRLRDQMGVPVATLLDTKGPEIRLGLFKGG 80
Cdd:COG0469 2 MRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 81 KAQLDAGSRFTLCTGECEGDSSHASITFPGLAADVKAGSTILLNDGAIELRVAGVREGAIECDVVNGGVISDHKGVNVPG 160
Cdd:COG0469 82 PVELKKGDTFTLTTDDVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNLPG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 161 IHLSMPYVSERDRADIMFGAEMGFDFIAASFVRCADDILQIRQILERQGnEKIRIIAKIENAEGVGNIDDILRVSDGIMV 240
Cdd:COG0469 162 VGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAG-GRAPIIAKIEKPEAVENLDEIIEASDGIMV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 241 ARGDMGVEVPFEEVPILQKMLISKCYNTGKMVITATQMLESMIHNPRPTRAEAADVANAIYDGTSAIMLSGETAAGDYPI 320
Cdd:COG0469 241 ARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYPV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 321 EAVSTMAQIAERTERDINYQKRFFARSGERVPDITNAISHATCTTAYDLGAAAIITVTWSGTTARMLSKFRPDIPIIACT 400
Cdd:COG0469 321 EAVETMARIAEEAEKSLDYRRILDRLRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILALT 400
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 493929278 401 HMPHTYHQLALSWGVTPLLADVKQSTDDLFAHAVERAQAAGFVRDGDIVVITAGVPLGINGTTNLLKVHVV 471
Cdd:COG0469 401 PNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
|
|
| PRK06354 |
PRK06354 |
pyruvate kinase; Provisional |
1-576 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235784 [Multi-domain] Cd Length: 590 Bit Score: 784.88 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 1 MRKTKIVCTLGPASDSEERIAQLISAGMNVARFNFSHGTHESHRATFERICRLRDQMGVPVATLLDTKGPEIRLGLFKGG 80
Cdd:PRK06354 7 MRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRLGRFEDG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 81 KAQLDAGSRFTLCTGECEGDSSHASITFPGLAADVKAGSTILLNDGAIELRVAGV--REGAIECDVVNGGVISDHKGVNV 158
Cdd:PRK06354 87 PIELKTGDEFILTSREVLGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEVdkADGELHCKVLVGGVLSNKKGVNF 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 159 PGIHLSMPYVSERDRADIMFGAEMGFDFIAASFVRCADDILQIRQILERQGNEKIRIIAKIENAEGVGNIDDILRVSDGI 238
Cdd:PRK06354 167 PGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHNGKHIPIIAKIEKQEAIDNIDAILELCDGL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 239 MVARGDMGVEVPFEEVPILQKMLISKCYNTGKMVITATQMLESMIHNPRPTRAEAADVANAIYDGTSAIMLSGETAAGDY 318
Cdd:PRK06354 247 MVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSNETAAGDY 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 319 PIEAVSTMAQIAERTERDINYQKRFFARSGERvPDITNAISHATCTTAYDLGAAAIITVTWSGTTARMLSKFRPDIPIIA 398
Cdd:PRK06354 327 PVEAVQTMATIAVRIEKDLPYRDILSKRPEFT-TTITNAISQAVSHIALQLDAAAIVTLTKSGATARNVSKYRPKTPILA 405
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 399 CTHMPHTYHQLALSWGVTPLLADVKQSTDDLFAHAVERAQAAGFVRDGDIVVITAGVPLGINGTTNLLKVHVVGDILVSG 478
Cdd:PRK06354 406 VTPNESVARRLQLVWGVTPLLVLDAPSTDETFDAAINVAQESGLLKQGDLVVITAGTLVGESGSTDLMKVHVVGAVVAKG 485
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 479 QGVNGRCAFGRLCVARTGEEaLASFNDGDILVVPQTSNELLPIMKKASGIVTERGGLNSHAAIVGMALDIPVIVFAENAT 558
Cdd:PRK06354 486 QGIGRKSVSGKARVAKTAAE-VAKVNEGDILVTPSTDADMIPAIEKAAAIITEEGGLTSHAAVVGLRLGIPVIVGVKNAT 564
|
570
....*....|....*...
gi 493929278 559 SILKSSTVVEIDAAAGTV 576
Cdd:PRK06354 565 SLIKDGQIITVDAARGVV 582
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
2-468 |
0e+00 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 614.67 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 2 RKTKIVCTLGPASDSEERIAQLISAGMNVARFNFSHGTHESHRATFERICRLRDQMGVPVATLLDTKGPEIRLGLFKGGK 81
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 82 AQLDAGSRFTLCT--GECEGDSSHASITFPGLAADVKAGSTILLNDGAIELRVAGVREGAIECDVVNGGVISDHKGVNVP 159
Cdd:TIGR01064 81 VKLKKGDKVIITTddIKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 160 GIHLSMPYVSERDRADIMFGAEMGFDFIAASFVRCADDILQIRQILERQGNEKIRIIAKIENAEGVGNIDDILRVSDGIM 239
Cdd:TIGR01064 161 GADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKDVKIIAKIENQEGVDNIDEIAEASDGIM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 240 VARGDMGVEVPFEEVPILQKMLISKCYNTGKMVITATQMLESMIHNPRPTRAEAADVANAIYDGTSAIMLSGETAAGDYP 319
Cdd:TIGR01064 241 VARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKYP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 320 IEAVSTMAQIAERTERDINYQKRF--FARSGERVPDITNAISHATCTTAYDLGAAAIITVTWSGTTARMLSKFRPDIPII 397
Cdd:TIGR01064 321 VEAVQMMAKIAKEAEKALAYLTNFndRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAPII 400
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 493929278 398 ACTHMPHTYHQLALSWGVTPLLADVKQSTDDLFAH-AVERAQAAGFVRDGDIVVITAGVPLGINGTTNLLKV 468
Cdd:TIGR01064 401 AVTPNERVARQLALYWGVFPFLVDEEPSDTDARVNkALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
1-471 |
0e+00 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 594.68 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 1 MRKTKIVCTLGPASDSEERIAQLISAGMNVARFNFSHGTHESHRATFERICRLRDQMGVPVATLLDTKGPEIRLGLFKGG 80
Cdd:cd00288 1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 81 KA-QLDAGSRFTLCT--GECEGDSSHASITFPGLAADVKAGSTILLNDGAIELRVAGVREGA-IECDVVNGGVISDHKGV 156
Cdd:cd00288 81 KDiSLKAGDKFLVTTdpAAKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKtLVCEVLNGGVLGSRKGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 157 NVPGIHLSMPYVSERDRADIMFGAEMGFDFIAASFVRCADDILQIRQILERQGnEKIRIIAKIENAEGVGNIDDILRVSD 236
Cdd:cd00288 161 NLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKG-KDIKIIAKIENQEGVNNFDEILEASD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 237 GIMVARGDMGVEVPFEEVPILQKMLISKCYNTGKMVITATQMLESMIHNPRPTRAEAADVANAIYDGTSAIMLSGETAAG 316
Cdd:cd00288 240 GIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKG 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 317 DYPIEAVSTMAQIAERTERDINYQKRF--FARSGERVPDITNAISHATCTTAYDLGAAAIITVTWSGTTARMLSKFRPDI 394
Cdd:cd00288 320 KYPVEAVKAMARICLEAEKALSHRVLFneMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNA 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 395 PIIACTHMPHTYHQLALSWGVTPLLAD-----VKQSTDDLFAHAVERAQAAGFVRDGDIVVITAGVPLGInGTTNLLKVH 469
Cdd:cd00288 400 PIIAVTRNEQTARQLHLYRGVYPVLFEepkpgWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGS-GSTNTMRIL 478
|
..
gi 493929278 470 VV 471
Cdd:cd00288 479 TV 480
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
1-343 |
2.24e-159 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 459.53 E-value: 2.24e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 1 MRKTKIVCTLGPASDSEERIAQLISAGMNVARFNFSHGTHESHRATFERICRLRDQMGVPVATLLDTKGPEIRLGLFKGG 80
Cdd:pfam00224 1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 81 KA--QLDAGSRFTLCTGE---CEGDSSHASITFPGLAADVKAGSTILLNDGAIELRVAGV-REGAIECDVVNGGVISDHK 154
Cdd:pfam00224 81 KKdiELKAGDEMIVSTDAkykGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKdDDKTLVVEVLNGGVIGSRK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 155 GVNVPGIHLSMPYVSERDRADIMFGAEMGFDFIAASFVRCADDILQIRQILERQGNEkIRIIAKIENAEGVGNIDDILRV 234
Cdd:pfam00224 161 GVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKN-IQIIAKIENQEGVNNFDEILEA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 235 SDGIMVARGDMGVEVPFEEVPILQKMLISKCYNTGKMVITATQMLESMIHNPRPTRAEAADVANAIYDGTSAIMLSGETA 314
Cdd:pfam00224 240 TDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETA 319
|
330 340
....*....|....*....|....*....
gi 493929278 315 AGDYPIEAVSTMAQIAERTERDINYQKRF 343
Cdd:pfam00224 320 KGNYPVEAVRMMHEICLEAEKALPHRNLF 348
|
|
| PpsA |
COG0574 |
Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and ... |
472-577 |
1.93e-24 |
|
Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Phosphoenolpyruvate synthase/pyruvate phosphate dikinase is part of the Pathway/BioSystem: Gluconeogenesis
Pssm-ID: 440339 [Multi-domain] Cd Length: 455 Bit Score: 106.45 E-value: 1.93e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 472 GDILVSGQGVNGRCAFGRLCVARtGEEALASFNDGDILVVPQTSNELLPIMKKASGIVTERGGLNSHAAIVGMALDIPVI 551
Cdd:COG0574 351 GEVLAKGLPASPGAASGKVVFIA-DEAELARFQEGVILVRDETDPDDVPGMKAAAGIVTERGGMTSHAAIVARELGIPAV 429
|
90 100
....*....|....*....|....*.
gi 493929278 552 VFAENATSILKSSTVVEIDAAAGTVS 577
Cdd:COG0574 430 VGCGDATRVLKDGDEITVDGTTGEVK 455
|
|
| PEP-utilizers |
pfam00391 |
PEP-utilizing enzyme, mobile domain; This domain is a "swivelling" beta/beta/alpha domain ... |
503-574 |
4.58e-23 |
|
PEP-utilizing enzyme, mobile domain; This domain is a "swivelling" beta/beta/alpha domain which is thought to be mobile in all proteins known to contain it.
Pssm-ID: 459796 [Multi-domain] Cd Length: 73 Bit Score: 92.86 E-value: 4.58e-23
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 493929278 503 FNDGDILVVPQTSNELLPIMKKASGIVTERGGLNSHAAIVGMALDIPVIVFAENATSILKSSTVVEIDAAAG 574
Cdd:pfam00391 2 LPEGVILVAPDTTPSDTAGLDKAAGIVTERGGMTSHAAIVARELGIPAVVGVGDATILLKEGDLVTVDGSTG 73
|
|
| PEP_synth |
TIGR01418 |
phosphoenolpyruvate synthase; Also called pyruvate,water dikinase and PEP synthase. The member ... |
467-574 |
1.66e-21 |
|
phosphoenolpyruvate synthase; Also called pyruvate,water dikinase and PEP synthase. The member from Methanococcus jannaschii contains a large intein. This enzyme generates phosphoenolpyruvate (PEP) from pyruvate, hydrolyzing ATP to AMP and releasing inorganic phosphate in the process. The enzyme shows extensive homology to other enzymes that use PEP as substrate or product. This enzyme may provide PEP for gluconeogenesis, for PTS-type carbohydrate transport systems, or for other processes. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273612 [Multi-domain] Cd Length: 786 Bit Score: 99.04 E-value: 1.66e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 467 KVHVVGDILVSGQGVNGRCAFGRLCVARTGEEAlASFNDGDILVVPQTSNELLPIMKKASGIVTERGGLNSHAAIVGMAL 546
Cdd:TIGR01418 347 ELKGKGKVLVTGRAAGPGIASGKVKVIFDLKEM-DKFEEGDILVTDMTDPDWEPAMKRASAIVTNEGGMTCHAAIVAREL 425
|
90 100
....*....|....*....|....*...
gi 493929278 547 DIPVIVFAENATSILKSSTVVEIDAAAG 574
Cdd:TIGR01418 426 GIPAVVGTGDATKTLKDGMEVTVDCAEG 453
|
|
| PRK06464 |
PRK06464 |
phosphoenolpyruvate synthase; Validated |
472-575 |
5.74e-20 |
|
phosphoenolpyruvate synthase; Validated
Pssm-ID: 235809 [Multi-domain] Cd Length: 795 Bit Score: 94.04 E-value: 5.74e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 472 GDILVSGQGVNGRCAFGRLCVARTGEEaLASFNDGDILVVPQTSNELLPIMKKASGIVTERGGLNSHAAIVGMALDIPVI 551
Cdd:PRK06464 353 GKVLVEGRAIGPGIGSGKVRVILDISE-MDKVQPGDVLVTDMTDPDWEPVMKRASAIVTNRGGRTCHAAIIARELGIPAV 431
|
90 100
....*....|....*....|....
gi 493929278 552 VFAENATSILKSSTVVEIDAAAGT 575
Cdd:PRK06464 432 VGTGNATEVLKDGQEVTVSCAEGD 455
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
1-471 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 788.46 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 1 MRKTKIVCTLGPASDSEERIAQLISAGMNVARFNFSHGTHESHRATFERICRLRDQMGVPVATLLDTKGPEIRLGLFKGG 80
Cdd:COG0469 2 MRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 81 KAQLDAGSRFTLCTGECEGDSSHASITFPGLAADVKAGSTILLNDGAIELRVAGVREGAIECDVVNGGVISDHKGVNVPG 160
Cdd:COG0469 82 PVELKKGDTFTLTTDDVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNLPG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 161 IHLSMPYVSERDRADIMFGAEMGFDFIAASFVRCADDILQIRQILERQGnEKIRIIAKIENAEGVGNIDDILRVSDGIMV 240
Cdd:COG0469 162 VGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAG-GRAPIIAKIEKPEAVENLDEIIEASDGIMV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 241 ARGDMGVEVPFEEVPILQKMLISKCYNTGKMVITATQMLESMIHNPRPTRAEAADVANAIYDGTSAIMLSGETAAGDYPI 320
Cdd:COG0469 241 ARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYPV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 321 EAVSTMAQIAERTERDINYQKRFFARSGERVPDITNAISHATCTTAYDLGAAAIITVTWSGTTARMLSKFRPDIPIIACT 400
Cdd:COG0469 321 EAVETMARIAEEAEKSLDYRRILDRLRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILALT 400
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 493929278 401 HMPHTYHQLALSWGVTPLLADVKQSTDDLFAHAVERAQAAGFVRDGDIVVITAGVPLGINGTTNLLKVHVV 471
Cdd:COG0469 401 PNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
|
|
| PRK06354 |
PRK06354 |
pyruvate kinase; Provisional |
1-576 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235784 [Multi-domain] Cd Length: 590 Bit Score: 784.88 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 1 MRKTKIVCTLGPASDSEERIAQLISAGMNVARFNFSHGTHESHRATFERICRLRDQMGVPVATLLDTKGPEIRLGLFKGG 80
Cdd:PRK06354 7 MRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRLGRFEDG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 81 KAQLDAGSRFTLCTGECEGDSSHASITFPGLAADVKAGSTILLNDGAIELRVAGV--REGAIECDVVNGGVISDHKGVNV 158
Cdd:PRK06354 87 PIELKTGDEFILTSREVLGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEVdkADGELHCKVLVGGVLSNKKGVNF 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 159 PGIHLSMPYVSERDRADIMFGAEMGFDFIAASFVRCADDILQIRQILERQGNEKIRIIAKIENAEGVGNIDDILRVSDGI 238
Cdd:PRK06354 167 PGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHNGKHIPIIAKIEKQEAIDNIDAILELCDGL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 239 MVARGDMGVEVPFEEVPILQKMLISKCYNTGKMVITATQMLESMIHNPRPTRAEAADVANAIYDGTSAIMLSGETAAGDY 318
Cdd:PRK06354 247 MVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSNETAAGDY 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 319 PIEAVSTMAQIAERTERDINYQKRFFARSGERvPDITNAISHATCTTAYDLGAAAIITVTWSGTTARMLSKFRPDIPIIA 398
Cdd:PRK06354 327 PVEAVQTMATIAVRIEKDLPYRDILSKRPEFT-TTITNAISQAVSHIALQLDAAAIVTLTKSGATARNVSKYRPKTPILA 405
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 399 CTHMPHTYHQLALSWGVTPLLADVKQSTDDLFAHAVERAQAAGFVRDGDIVVITAGVPLGINGTTNLLKVHVVGDILVSG 478
Cdd:PRK06354 406 VTPNESVARRLQLVWGVTPLLVLDAPSTDETFDAAINVAQESGLLKQGDLVVITAGTLVGESGSTDLMKVHVVGAVVAKG 485
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 479 QGVNGRCAFGRLCVARTGEEaLASFNDGDILVVPQTSNELLPIMKKASGIVTERGGLNSHAAIVGMALDIPVIVFAENAT 558
Cdd:PRK06354 486 QGIGRKSVSGKARVAKTAAE-VAKVNEGDILVTPSTDADMIPAIEKAAAIITEEGGLTSHAAVVGLRLGIPVIVGVKNAT 564
|
570
....*....|....*...
gi 493929278 559 SILKSSTVVEIDAAAGTV 576
Cdd:PRK06354 565 SLIKDGQIITVDAARGVV 582
|
|
| PRK05826 |
PRK05826 |
pyruvate kinase; Provisional |
1-461 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235619 [Multi-domain] Cd Length: 465 Bit Score: 649.52 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 1 MRKTKIVCTLGPASDSEERIAQLISAGMNVARFNFSHGTHESHRATFERICRLRDQMGVPVATLLDTKGPEIRLGLFKGG 80
Cdd:PRK05826 3 LRRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFKEG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 81 KAQLDAGSRFTLCTGEC-EGDSSHASITFPGLAADVKAGSTILLNDGAIELRVAGVREGAIECDVVNGGVISDHKGVNVP 159
Cdd:PRK05826 83 KITLKTGDKFTLDTDQKeEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGINIP 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 160 GIHLSMPYVSERDRADIMFGAEMGFDFIAASFVRCADDILQIRQILERQGNEKIRIIAKIENAEGVGNIDDILRVSDGIM 239
Cdd:PRK05826 163 GGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCPHAKIIAKIERAEAVDNIDEIIEASDGIM 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 240 VARGDMGVEVPFEEVPILQKMLISKCYNTGKMVITATQMLESMIHNPRPTRAEAADVANAIYDGTSAIMLSGETAAGDYP 319
Cdd:PRK05826 243 VARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAGKYP 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 320 IEAVSTMAQIAERTE--RDINYQKRFFARSGERvpdITNAISHATCTTAYDL-GAAAIITVTWSGTTARMLSKFRPDIPI 396
Cdd:PRK05826 323 VEAVEAMARICKGAEkeFSINLSKHRLDRQFDR---IDEAIAMSAMYAANHLkGVKAIVALTESGRTARLISRFRPGAPI 399
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 493929278 397 IACTHMPHTYHQLALSWGVTPLLADVKQSTDDLFAHAVERAQAAGFVRDGDIVVITAGVPLGING 461
Cdd:PRK05826 400 FAVTRDEKTQRRLALYRGVYPVLFDSAADTDDAAEEALRLLLEKGLVESGDLVVVTSGDPMGTAG 464
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
2-468 |
0e+00 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 614.67 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 2 RKTKIVCTLGPASDSEERIAQLISAGMNVARFNFSHGTHESHRATFERICRLRDQMGVPVATLLDTKGPEIRLGLFKGGK 81
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 82 AQLDAGSRFTLCT--GECEGDSSHASITFPGLAADVKAGSTILLNDGAIELRVAGVREGAIECDVVNGGVISDHKGVNVP 159
Cdd:TIGR01064 81 VKLKKGDKVIITTddIKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 160 GIHLSMPYVSERDRADIMFGAEMGFDFIAASFVRCADDILQIRQILERQGNEKIRIIAKIENAEGVGNIDDILRVSDGIM 239
Cdd:TIGR01064 161 GADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKDVKIIAKIENQEGVDNIDEIAEASDGIM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 240 VARGDMGVEVPFEEVPILQKMLISKCYNTGKMVITATQMLESMIHNPRPTRAEAADVANAIYDGTSAIMLSGETAAGDYP 319
Cdd:TIGR01064 241 VARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKYP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 320 IEAVSTMAQIAERTERDINYQKRF--FARSGERVPDITNAISHATCTTAYDLGAAAIITVTWSGTTARMLSKFRPDIPII 397
Cdd:TIGR01064 321 VEAVQMMAKIAKEAEKALAYLTNFndRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAPII 400
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 493929278 398 ACTHMPHTYHQLALSWGVTPLLADVKQSTDDLFAH-AVERAQAAGFVRDGDIVVITAGVPLGINGTTNLLKV 468
Cdd:TIGR01064 401 AVTPNERVARQLALYWGVFPFLVDEEPSDTDARVNkALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
1-471 |
0e+00 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 594.68 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 1 MRKTKIVCTLGPASDSEERIAQLISAGMNVARFNFSHGTHESHRATFERICRLRDQMGVPVATLLDTKGPEIRLGLFKGG 80
Cdd:cd00288 1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 81 KA-QLDAGSRFTLCT--GECEGDSSHASITFPGLAADVKAGSTILLNDGAIELRVAGVREGA-IECDVVNGGVISDHKGV 156
Cdd:cd00288 81 KDiSLKAGDKFLVTTdpAAKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKtLVCEVLNGGVLGSRKGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 157 NVPGIHLSMPYVSERDRADIMFGAEMGFDFIAASFVRCADDILQIRQILERQGnEKIRIIAKIENAEGVGNIDDILRVSD 236
Cdd:cd00288 161 NLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKG-KDIKIIAKIENQEGVNNFDEILEASD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 237 GIMVARGDMGVEVPFEEVPILQKMLISKCYNTGKMVITATQMLESMIHNPRPTRAEAADVANAIYDGTSAIMLSGETAAG 316
Cdd:cd00288 240 GIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKG 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 317 DYPIEAVSTMAQIAERTERDINYQKRF--FARSGERVPDITNAISHATCTTAYDLGAAAIITVTWSGTTARMLSKFRPDI 394
Cdd:cd00288 320 KYPVEAVKAMARICLEAEKALSHRVLFneMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNA 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 395 PIIACTHMPHTYHQLALSWGVTPLLAD-----VKQSTDDLFAHAVERAQAAGFVRDGDIVVITAGVPLGInGTTNLLKVH 469
Cdd:cd00288 400 PIIAVTRNEQTARQLHLYRGVYPVLFEepkpgWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGS-GSTNTMRIL 478
|
..
gi 493929278 470 VV 471
Cdd:cd00288 479 TV 480
|
|
| PRK09206 |
PRK09206 |
pyruvate kinase PykF; |
1-471 |
0e+00 |
|
pyruvate kinase PykF;
Pssm-ID: 181699 [Multi-domain] Cd Length: 470 Bit Score: 555.05 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 1 MRKTKIVCTLGPASDSEERIAQLISAGMNVARFNFSHGTHESHRatfERICRLRDQM---GVPVATLLDTKGPEIRLGLF 77
Cdd:PRK09206 1 MKKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHG---QRIKNLRNVMsktGKKAAILLDTKGPEIRTMKL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 78 KGGK-AQLDAGSRFTLCTG-ECEGDSSHASITFPGLAADVKAGSTILLNDGAIELRVAGVREGAIECDVVNGGVISDHKG 155
Cdd:PRK09206 78 EGGNdVSLKAGQTFTFTTDkSVVGNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGDLGENKG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 156 VNVPGIHLSMPYVSERDRADIMFGAEMGFDFIAASFVRCADDILQIRQILERQGNEKIRIIAKIENAEGVGNIDDILRVS 235
Cdd:PRK09206 158 VNLPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGGENIQIISKIENQEGLNNFDEILEAS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 236 DGIMVARGDMGVEVPFEEVPILQKMLISKCYNTGKMVITATQMLESMIHNPRPTRAEAADVANAIYDGTSAIMLSGETAA 315
Cdd:PRK09206 238 DGIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAK 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 316 GDYPIEAVSTMAQIAERTERDINyqKRFFARSGERVPDITNAISHATCTTAYDLGAAAIITVTWSGTTARMLSKFRPDIP 395
Cdd:PRK09206 318 GKYPLEAVSIMATICERTDRVMN--SRLESNNDNRKLRITEAVCRGAVETAEKLDAPLIVVATQGGKSARSVRKYFPDAT 395
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 493929278 396 IIACTHMPHTYHQLALSWGVTPLLADVKQSTDDLFAHAVERAQAAGFVRDGDIVVITAGVpLGINGTTNLLKVHVV 471
Cdd:PRK09206 396 ILALTTNEKTARQLVLSKGVVPQLVKEIASTDDFYRLGKELALQSGLAQKGDVVVMVSGA-LVPSGTTNTASVHVL 470
|
|
| PRK06247 |
PRK06247 |
pyruvate kinase; Provisional |
2-472 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 180487 [Multi-domain] Cd Length: 476 Bit Score: 541.82 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 2 RKTKIVCTLGPASDSEERIAQLISAGMNVARFNFSHGTHESHRATFERICRLRDQMGVPVATLLDTKGPEIRLGLFKGGK 81
Cdd:PRK06247 5 RRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDETGRPIGILADLQGPKLRLGRFADGK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 82 AQLDAGSRFTLCTGECEGDSSHASITFPGLAADVKAGSTILLNDGAIELRVAGVREGAIECDVVNGGVISDHKGVNVPGI 161
Cdd:PRK06247 85 VQLANGQTFRLDVDDAPGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGGPVSDRKGVSLPGT 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 162 HLSMPYVSERDRADIMFGAEMGFDFIAASFVRCADDILQIRQILERqgneKIRIIAKIENAEGVGNIDDILRVSDGIMVA 241
Cdd:PRK06247 165 VLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKIIGG----RVPVMAKIEKPQAIDRLEAIVEASDAIMVA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 242 RGDMGVEVPFEEVPILQKMLISKCYNTGKMVITATQMLESMIHNPRPTRAEAADVANAIYDGTSAIMLSGETAAGDYPIE 321
Cdd:PRK06247 241 RGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETASGKYPVE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 322 AVSTMAQIAERTERDINYQKRFFARSGERVPDITNAISHATCTTAYDLGAAAIITVTWSGTTARMLSKFRPDIPIIACTH 401
Cdd:PRK06247 321 AVRTMARIIRQVERDPTYPPLIHAQRPQPEATKRDAISYAARDIAERLDLAALVAYTSSGDTALRAARERPPLPILALTP 400
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 493929278 402 MPHTYHQLALSWGVTPLLADVKQSTDDLFAHAVERAQAAGFVRDGDIVVITAGVPLGINGTTNLLKVHVVG 472
Cdd:PRK06247 401 NPETARRLALTWGVHCVVVDDARDTDDMVRRADRIALAEGFYKRGDRVVIVAGVPPGTPGSTNMLRIAYIG 471
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
1-343 |
2.24e-159 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 459.53 E-value: 2.24e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 1 MRKTKIVCTLGPASDSEERIAQLISAGMNVARFNFSHGTHESHRATFERICRLRDQMGVPVATLLDTKGPEIRLGLFKGG 80
Cdd:pfam00224 1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 81 KA--QLDAGSRFTLCTGE---CEGDSSHASITFPGLAADVKAGSTILLNDGAIELRVAGV-REGAIECDVVNGGVISDHK 154
Cdd:pfam00224 81 KKdiELKAGDEMIVSTDAkykGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKdDDKTLVVEVLNGGVIGSRK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 155 GVNVPGIHLSMPYVSERDRADIMFGAEMGFDFIAASFVRCADDILQIRQILERQGNEkIRIIAKIENAEGVGNIDDILRV 234
Cdd:pfam00224 161 GVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKN-IQIIAKIENQEGVNNFDEILEA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 235 SDGIMVARGDMGVEVPFEEVPILQKMLISKCYNTGKMVITATQMLESMIHNPRPTRAEAADVANAIYDGTSAIMLSGETA 314
Cdd:pfam00224 240 TDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETA 319
|
330 340
....*....|....*....|....*....
gi 493929278 315 AGDYPIEAVSTMAQIAERTERDINYQKRF 343
Cdd:pfam00224 320 KGNYPVEAVRMMHEICLEAEKALPHRNLF 348
|
|
| PTZ00066 |
PTZ00066 |
pyruvate kinase; Provisional |
2-468 |
9.06e-154 |
|
pyruvate kinase; Provisional
Pssm-ID: 173361 [Multi-domain] Cd Length: 513 Bit Score: 451.52 E-value: 9.06e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 2 RKTKIVCTLGPASDSEERIAQLISAGMNVARFNFSHGTHESHRATFERIcrLRDQMGVPVAT---LLDTKGPEIRLGLFK 78
Cdd:PTZ00066 38 KKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNV--REAAKARPNANlgiLLDTKGPEIRTGFLK 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 79 GGKA-QLDAGSRFTLCTG-ECEGDSSHASITFPGLAADVKAGSTILLNDGAIELRVAGVREGAIECDVVNGGVISDHKGV 156
Cdd:PTZ00066 116 NHKPiTLKEGQTLKITTDyTFLGDETCISCSYKKLPQSVKVGNIILIADGSLSCKVLEVHDDYIITKVLNNATIGERKNM 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 157 NVPGIHLSMPYVSERDRADIM-FGAEMGFDFIAASFVRCADDILQIRQILERQGnEKIRIIAKIENAEGVGNIDDILRVS 235
Cdd:PTZ00066 196 NLPGVKVELPVIGEKDKNDILnFAIPMGCDFIALSFVQSADDVRLCRQLLGERG-RHIKIIPKIENIEGLINFDEILAES 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 236 DGIMVARGDMGVEVPFEEVPILQKMLISKCYNTGKMVITATQMLESMIHNPRPTRAEAADVANAIYDGTSAIMLSGETAA 315
Cdd:PTZ00066 275 DGIMVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVMLSGETAN 354
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 316 GDYPIEAVSTMAQIAERTERDINYQKRFFARSGERVPDIT--NAISHATCTTAYDLGAAAIITVTWSGTTARMLSKFRPD 393
Cdd:PTZ00066 355 GKFPVEAVNIMAKICFEAETCIDYRVLYHAIHLAVPTPVSvqEAVARSAVETAEDINAKLIIALTETGNTARLISKYRPS 434
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 493929278 394 IPIIACTHMPHTYHQLALSWGVTPLLADVKQSTDDLFAHAVERAQAAGFVRDGDIVVITAGVPLGINGTTNLLKV 468
Cdd:PTZ00066 435 CTILALSASPSVVKSLSVARGVTTYVVNSFQGTDVVIRNAIALAKERGLVESGDSAIAVHGVKEEVAGSSNLMKV 509
|
|
| PLN02461 |
PLN02461 |
Probable pyruvate kinase |
3-450 |
1.39e-152 |
|
Probable pyruvate kinase
Pssm-ID: 215255 [Multi-domain] Cd Length: 511 Bit Score: 448.27 E-value: 1.39e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 3 KTKIVCTLGPASDSEERIAQLISAGMNVARFNFSHGTHESHRATFERicrLRDQM---GVPVATLLDTKGPEIRLGLFKG 79
Cdd:PLN02461 22 KTKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDN---LRQAMantGILCAVMLDTKGPEIRTGFLKD 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 80 GKA-QLDAGSRFTLCTG-ECEGDSSHASITFPGLAADVKAGSTILLNDGAIELRV--AGVREGAIECDVVNGGVISDHKG 155
Cdd:PLN02461 99 GKPvQLKQGQEITITTDySIKGDENMIAMSYKKLAVDVKPGSVILCADGTITLTVlsCDVEAGTVRCRCENSAMLGERKN 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 156 VNVPGIHLSMPYVSERDRADIM-FGAEMGFDFIAASFVRCADDILQIRQILERQGNeKIRIIAKIENAEGVGNIDDILRV 234
Cdd:PLN02461 179 VNLPGVVVDLPTLTEKDKEDILqWGVPNKIDFIALSFVRKGSDLVEVRKVLGEHAK-SILLISKVENQEGLDNFDDILAE 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 235 SDGIMVARGDMGVEVPFEEVPILQKMLISKCYNTGKMVITATQMLESMIHNPRPTRAEAADVANAIYDGTSAIMLSGETA 314
Cdd:PLN02461 258 SDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGETA 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 315 AGDYPIEAVSTMAQIAERTERDINYQKrFFARSGERVP---DITNAISHATCTTAYDLGAAAIITVTWSGTTARMLSKFR 391
Cdd:PLN02461 338 AGAYPELAVKTMARICREAEASLDYGA-LFKEIMRSAPlpmSPLESLASSAVRTANKVKASLIVVLTRGGTTARLVAKYR 416
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 493929278 392 PDIPII--------------ACTHMPHTYHQLaLSWGVTPLLADV------KQSTDDLFAHAVERAQAAGFVRDGDIVV 450
Cdd:PLN02461 417 PAVPILsvvvpeittdsfdwSCSDEAPARHSL-IYRGLIPVLAEGsakatdSESTEEILEAAIEHAKKKGLCKPGDSVV 494
|
|
| PykA2 |
COG3848 |
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms]; |
264-576 |
2.39e-148 |
|
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
Pssm-ID: 443058 Cd Length: 321 Bit Score: 430.09 E-value: 2.39e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 264 KCYNTGKMVITATQMLESMIHNPRPTRAEAADVANAIYDGTSAIMLSGETAAGDYPIEAVSTMAQIAERTERDINYQKRF 343
Cdd:COG3848 1 KCNAAGKPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEDLEYREQR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 344 FARSGERVPDITNAISHATCTTAYDLGAAAIITVTWSGTTARMLSKFRPDIPIIACTHMPHTYHQLALSWGVTPLLADVK 423
Cdd:COG3848 81 VPRAKESSTTITDAISHAVATTAADLGAAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGVYPLLVEES 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 424 QSTDDLFAHAVERAQAAGFVRDGDIVVITAGVPLGINGTTNLLKVHVVGDILVSGQGVNGRCAFGRLCVARTGEEALASF 503
Cdd:COG3848 161 ASTDEMFAVAVALALEAGLVKDGDLVVITAGVPVGVSGTTNLLKVHVVGDVLAKGQGIGRGSVTGKAVVARSAEEALEKF 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 493929278 504 NDGDILVVPQTSNELLPIMKKASGIVTERGGLNSHAAIVGMALDIPVIVFAENATSILKSSTVVEIDAAAGTV 576
Cdd:COG3848 241 EEGDILVVPSTDAEFVPAIEKAAGIITEEGGLTSHAAIVGLELGIPVIVGAEGATEILKDGQVVTVDAERGVV 313
|
|
| PTZ00300 |
PTZ00300 |
pyruvate kinase; Provisional |
28-451 |
7.87e-125 |
|
pyruvate kinase; Provisional
Pssm-ID: 140321 [Multi-domain] Cd Length: 454 Bit Score: 375.16 E-value: 7.87e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 28 MNVARFNFSHGTHESHRATFERICRLRDQMGVPVATLLDTKGPEIRLGLFKGGKAQLDAGSRFTLCTG---ECEGDSSHA 104
Cdd:PTZ00300 1 MSVARMNFSHGSHEYHQTTINNVRQAAAELGVNIAIALDTKGPEIRTGLFVGGEAVMERGATCYVTTDpafADKGTKDKF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 105 SITFPGLAADVKAGSTILLNDGAIELRVAGVR-EGAIECDVVNGGVISDHKGVNVPGIHLSMPYVSERDRADIMFGAEMG 183
Cdd:PTZ00300 81 YIDYQNLSKVVRPGGYIYIDDGILILHVQSHEdEQTLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCADLQFGVEQG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 184 FDFIAASFVRCADDILQIRQILERQGNEkIRIIAKIENAEGVGNIDDILRVSDGIMVARGDMGVEVPFEEVPILQKMLIS 263
Cdd:PTZ00300 161 VDMIFASFIRSAEQVGEVRKALGAKGGD-IMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKILIS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 264 KCYNTGKMVITATQMLESMIHNPRPTRAEAADVANAIYDGTSAIMLSGETAAGDYPIEAVSTMAQIAERTERDINyQKRF 343
Cdd:PTZ00300 240 KCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSAVN-EYVF 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 344 FaRSGERVPDITNAISHATCTTA----YDLGAAAIITVTWSGTTARMLSKFRPDIPIIACTHMPHTYHQLALSWGVTPLL 419
Cdd:PTZ00300 319 F-NSIKKLQPIPMSAEEAVCSSAvnsvYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVESVF 397
|
410 420 430
....*....|....*....|....*....|....*..
gi 493929278 420 ADVK-----QSTDDLFAHAVERAQAAGFVRDGDIVVI 451
Cdd:PTZ00300 398 FDAErlghdEGKEQRVAMGVGFAKSKGYVQSGDLMVV 434
|
|
| PRK06739 |
PRK06739 |
pyruvate kinase; Validated |
7-334 |
3.03e-116 |
|
pyruvate kinase; Validated
Pssm-ID: 180676 [Multi-domain] Cd Length: 352 Bit Score: 349.63 E-value: 3.03e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 7 VCTLGPASDSEERIAQLISAGMNVARFNFSHGTHESHRAtferICRLRDQMGVPVATLLDTKGPEIRLGLFKGGKAQLDA 86
Cdd:PRK06739 6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKD----IIRLVKSLDDSIKILGDVQGPKIRLGEIKGEQITLQA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 87 GSRFTLCTGECEGDSSHASITFPGLAADVKAGSTILLNDGAIELRVAGVREGAIECDVVNGGVISDHKGVNVPGIHLSMP 166
Cdd:PRK06739 82 GDSFILHTQPVTGSSTEASVDYEGIANDVKVGSRILMNDGEVELIVEKVSTDKIETKVKTGGNISSHKGVNLPGAIVRLP 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 167 YVSERDRADIMFGAEMGFDFIAASFVRCADDILQIRQILERQGNEKIRIIAKIENAEGVGNIDDILRVSDGIMVARGDMG 246
Cdd:PRK06739 162 AITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETSPNLIAKIETMEAIENFQDICKEADGIMIARGDLG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 247 VEVPFEEVPILQKMLISKCYNTGKMVITATQMLESMIHNPRPTRAEAADVANAIYDGTSAIMLSGETAAGDYPIEAVSTM 326
Cdd:PRK06739 242 VELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESASGEHPIESVSTL 321
|
....*...
gi 493929278 327 AQIAERTE 334
Cdd:PRK06739 322 RLVSEFAE 329
|
|
| PLN02623 |
PLN02623 |
pyruvate kinase |
2-451 |
1.61e-105 |
|
pyruvate kinase
Pssm-ID: 215334 [Multi-domain] Cd Length: 581 Bit Score: 329.58 E-value: 1.61e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 2 RKTKIVCTLGPASDSEERIAQLISAGMNVARFNFSHGTHESHRATFERICRLRDQMGVPV-ATLLDTKGPEIRLGLFKGg 80
Cdd:PLN02623 110 RKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLVKEYNAQSKDNViAIMLDTKGPEVRSGDLPQ- 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 81 KAQLDAGSRFTLCTGECEGDSSHASITFPGLAADVKAGSTILLNDGAIELRVAGVREGAIECDVVNGGVISDHKGVNVPG 160
Cdd:PLN02623 189 PIMLEEGQEFTFTIKRGVSTEDCVSVNYDDFVNDVEVGDMLLVDGGMMSLAVKSKTSDSVKCEVVDGGELKSRRHLNVRG 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 161 IHLSMPYVSERDRADIMFGAEMGFDFIAASFVRCADDILQIRQILERQgNEKIRIIAKIENAEGVGNIDDILRVSDGIMV 240
Cdd:PLN02623 269 KSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSC-NADIHVIVKIESADSIPNLHSIITASDGAMV 347
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 241 ARGDMGVEVPFEEVPILQKMLISKCYNTGKMVITATQMLESMIHNPRPTRAEAADVANAIYDGTSAIMLSGETAAGDYPI 320
Cdd:PLN02623 348 ARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKFPL 427
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 321 EAVSTMAQIAERTERDINyqkrffarSGERVPDITNAI---------SHATcTTAYDLGaAAIITVTWSGTTARMLSKFR 391
Cdd:PLN02623 428 KAVKVMHTVALRTEATLP--------EGTTPPNLGQAFknhmsemfaFHAT-MMANTLG-TSIIVFTRTGFMAILLSHYR 497
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 392 PDIPIIACTHMPHTYHQLALSWGVTPLLADVKQSTDDLFAHAVERAQAAGFVRDGDIVVI 451
Cdd:PLN02623 498 PSGTIFAFTNEKRIQQRLALYQGVCPIYMQFSDDAEETFARALSLLLNKGMVKEGEEVAL 557
|
|
| PLN02762 |
PLN02762 |
pyruvate kinase complex alpha subunit |
1-451 |
1.26e-101 |
|
pyruvate kinase complex alpha subunit
Pssm-ID: 215407 [Multi-domain] Cd Length: 509 Bit Score: 317.46 E-value: 1.26e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 1 MRKTKIVCTLGPASDSEERIAQLISAGMNVARFNFSHGTHESHRATFERICRLRDQMGVPVATLLDTKGPEIRLGLFkGG 80
Cdd:PLN02762 24 TRRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRLNEEKGFAVAVMMDTEGSEIHMGDL-GG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 81 KAQLDA--GSRFTLCTGECEGDSSHASIT--FPGLAADVKAGSTILLNDGAIELRVAGVREGAIECDVVNGGVISDHKGV 156
Cdd:PLN02762 103 ASSAKAedGEEWTFTVRKFDGSRPEFTIQvnYDGFAEDVKVGDELVVDGGMVRFEVIEKIGPDVKCKCTDPGLLLPRANL 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 157 N-------VPGIHLSMPYVSERDRADIMFGAEMGFDFIAASFVRCADDILQIRQILERQG-NEKIRIIAKIENAEGVGNI 228
Cdd:PLN02762 183 TfwrdgslVRERNAMLPTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAARSrDSDIGVIAKIESLDSLKNL 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 229 DDILRVSDGIMVARGDMGVEVPFEEVPILQKMLISKCYNTGKMVITATQMLESMIHNPRPTRAEAADVANAIYDGTSAIM 308
Cdd:PLN02762 263 EEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQRADALM 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 309 LSGETAAGDYPIEAVSTMAQIAERTERDINYQKRffaRSGERVPDITNA----ISHATCTTAY----DLGAAAIITVTWS 380
Cdd:PLN02762 343 LSGESAMGLYPEKALSVLRSVSLRMELWSREEKR---HEALELPQLSSSlsdrISEEICNSAAkmanNLGVDAIFVYTKH 419
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 493929278 381 GTTARMLSKFRPDIPIIACTHMPHTYHQLALSWGVTPLLADVKQSTDDLFAHAVERAQAAGFVRDGDIVVI 451
Cdd:PLN02762 420 GHMASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPFRLDFSDDMESNLNKTFSLLKARGMIKSGDLVIA 490
|
|
| PLN02765 |
PLN02765 |
pyruvate kinase |
4-473 |
6.91e-100 |
|
pyruvate kinase
Pssm-ID: 215409 [Multi-domain] Cd Length: 526 Bit Score: 313.14 E-value: 6.91e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 4 TKIVCTLGPASDSEERIAQLISAGMNVARFNFSHGTHESHRATFE----------RICrlrdqmgvpvATLLDTKGPEIR 73
Cdd:PLN02765 30 TKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLEnlkiavkntkKLC----------AVMLDTVGPELQ 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 74 LGLFKGGKAQLDAGSRFTLCTGECEGDSSHA-SITFPGLAADVKAGSTILLND--------GAIELRVAGVREGAIECDV 144
Cdd:PLN02765 100 VINKTEKPISLKAGNTVTLTPDQSKEASSEVlPINFPGLAKAVKPGDTIFVGQylftgsetTSVWLEVDEVKGDDVVCTV 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 145 VNGGVISdhkG----VNVPGIHLSMPYVSERDRADI-MFGAEMGFDFIAASFVRCADDILQIRQILERQGNEKIRIIAKI 219
Cdd:PLN02765 180 KNSATLA---GslftLHVSQVRIDLPTLSEKDKEVIsTWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGLSQTQIFAKI 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 220 ENAEGVGNIDDILRVSDGIMVARGDMGVEVPFEEVPILQKMLISKCYNTGKMVITaTQMLESMIHNPRPTRAEAADVANA 299
Cdd:PLN02765 257 ENVEGLTHFDEILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDVANA 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 300 IYDGTSAIMLSGETAAGDYPIEAVSTMAQI---AERTERDINYQKRFFARSGERVPDItNAISHATCTTAYDLGAAAIIT 376
Cdd:PLN02765 336 VLDGADAILLGAETLRGLYPVETISTVGRIcaeAEKVFNQDLYFKKTVKYVGEPMSHL-ESIASSAVRAAIKVKASVIIV 414
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 377 VTWSGTTARMLSKFRPDIPIIACT-------HMPHTY------HQLALSWGVTPLLADVKQSTDDLFAH-------AVER 436
Cdd:PLN02765 415 FTSSGRAARLIAKYRPTMPVLSVViprlktnQLKWSFtgafqaRQCLIVRGLFPMLADPRHSAESTSATnesvlkvALDH 494
|
490 500 510
....*....|....*....|....*....|....*..
gi 493929278 437 AQAAGFVRDGDIVVITAGVplginGTTNLLKVHVVGD 473
Cdd:PLN02765 495 GKAAGVIKSHDRVVVCQKV-----GDSSVVKIIELDD 526
|
|
| PK_C |
pfam02887 |
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ... |
356-469 |
6.86e-51 |
|
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.
Pssm-ID: 460738 [Multi-domain] Cd Length: 114 Bit Score: 170.74 E-value: 6.86e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 356 NAISHATCTTAYDLGAAAIITVTWSGTTARMLSKFRPDIPIIACTHMPHTYHQLALSWGVTPLLADVKQSTDDLFAHAVE 435
Cdd:pfam02887 1 EAIAHAAVEAAEELGAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDEAETTDEMLRRAVK 80
|
90 100 110
....*....|....*....|....*....|....
gi 493929278 436 RAQAAGFVRDGDIVVITAGVPLGINGTTNLLKVH 469
Cdd:pfam02887 81 VAKEAGLVKKGDLVVITAGVPFGVSGTTNTLKVI 114
|
|
| PRK08187 |
PRK08187 |
pyruvate kinase; Validated |
2-335 |
2.95e-42 |
|
pyruvate kinase; Validated
Pssm-ID: 236178 Cd Length: 493 Bit Score: 158.64 E-value: 2.95e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 2 RKTKIVCTL-GPASDSEERIAQLISAGMNVARFNFSHGTHESHRATFERICRLRDQMGVPVATLLDTKGPEIRLGLFKG- 79
Cdd:PRK08187 133 RRTRIMVTLpSEAADDPDFVLRLAERGMDCARINCAHDDPAAWQAMIGHLRQAERATGRRCKILMDLAGPKIRTGAVAGp 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 80 -GKAQLDAGSRFTLCTGECEG--DSSHASI--TFPGLAADVKAGSTILLNDGAIELRVAGVREGAIECDVV----NGGVI 150
Cdd:PRK08187 213 lGKTRLYTGDRLALVAQGPPRriDEEHFQVtcTLPEILARLAVGARVWIDDGKLGARVERVGPGGALLEVTharpKGLKL 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 151 SDHKGVNVPGIHLSMPYVSERDRADIMFGAEMGfDFIAASFVRCADDILQIRQILERQGNEKIR---IIAKIENAEGVGN 227
Cdd:PRK08187 293 KPEKGLNFPDTALDLPALTEKDRADLDFVARHA-DLVGYSFVQSPGDVEALQAALAARRPDDWRklgLVLKIETPRAVAN 371
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 228 IDDIL-----RVSDGIMVARGDMGVEVPFEEVPILQKMLISKCYNTGKMVITATQMLESMIHNPRPTRAEAADVANAiyD 302
Cdd:PRK08187 372 LPELIvqaagRQPFGVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSRAEMTDAAMA--A 449
|
330 340 350
....*....|....*....|....*....|...
gi 493929278 303 GTSAIMLSgetaAGDYPIEAVSTMAQIAERTER 335
Cdd:PRK08187 450 RAECVMLN----KGPYLVEAVTFLDDLLARMDG 478
|
|
| PRK14725 |
PRK14725 |
pyruvate kinase; Provisional |
80-335 |
1.53e-36 |
|
pyruvate kinase; Provisional
Pssm-ID: 237804 Cd Length: 608 Bit Score: 144.32 E-value: 1.53e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 80 GKAQLDAGSRFTLCTGECEGDSSHA-------SITFPGLAADVKAGSTILLNDGAIELRVAGVREGAIECDVVN---GGV 149
Cdd:PRK14725 331 QKLRLKVGDRLVLTRDDAPGDPAQGdappariSCTLPEAFRAARVGERVWFDDGKIGAVVVKVEADEVELRITHarpGGS 410
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 150 -ISDHKGVNVPGIHLSMPYVSERDRADIMFGAEMGfDFIAASFVRCADDILQIRQILERQGNEKIRIIAKIENAEGVGNI 228
Cdd:PRK14725 411 kLKAGKGINLPDSHLPLPALTDKDLEDLAFVAKHA-DIVALSFVRSPEDVRLLLDALEKLGADDLGVVLKIETRRAFENL 489
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 229 DDIL-----RVSDGIMVARGDMGVEVPFEEVPILQKMLISKCYNTGKMVITATQMLESMIHNPRPTRAEAADVANAIYdg 303
Cdd:PRK14725 490 PRILleamrHPRFGVMIARGDLAVEVGFERLAEVQEEILWLCEAAHVPVIWATQVLESLAKKGLPSRAEITDAAMALR-- 567
|
250 260 270
....*....|....*....|....*....|..
gi 493929278 304 TSAIMLSgetaAGDYPIEAVSTMAQIAERTER 335
Cdd:PRK14725 568 AECVMLN----KGPHIVEAVRVLDDILRRMEE 595
|
|
| PpsA |
COG0574 |
Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and ... |
472-577 |
1.93e-24 |
|
Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Phosphoenolpyruvate synthase/pyruvate phosphate dikinase is part of the Pathway/BioSystem: Gluconeogenesis
Pssm-ID: 440339 [Multi-domain] Cd Length: 455 Bit Score: 106.45 E-value: 1.93e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 472 GDILVSGQGVNGRCAFGRLCVARtGEEALASFNDGDILVVPQTSNELLPIMKKASGIVTERGGLNSHAAIVGMALDIPVI 551
Cdd:COG0574 351 GEVLAKGLPASPGAASGKVVFIA-DEAELARFQEGVILVRDETDPDDVPGMKAAAGIVTERGGMTSHAAIVARELGIPAV 429
|
90 100
....*....|....*....|....*.
gi 493929278 552 VFAENATSILKSSTVVEIDAAAGTVS 577
Cdd:COG0574 430 VGCGDATRVLKDGDEITVDGTTGEVK 455
|
|
| PEP-utilizers |
pfam00391 |
PEP-utilizing enzyme, mobile domain; This domain is a "swivelling" beta/beta/alpha domain ... |
503-574 |
4.58e-23 |
|
PEP-utilizing enzyme, mobile domain; This domain is a "swivelling" beta/beta/alpha domain which is thought to be mobile in all proteins known to contain it.
Pssm-ID: 459796 [Multi-domain] Cd Length: 73 Bit Score: 92.86 E-value: 4.58e-23
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 493929278 503 FNDGDILVVPQTSNELLPIMKKASGIVTERGGLNSHAAIVGMALDIPVIVFAENATSILKSSTVVEIDAAAG 574
Cdd:pfam00391 2 LPEGVILVAPDTTPSDTAGLDKAAGIVTERGGMTSHAAIVARELGIPAVVGVGDATILLKEGDLVTVDGSTG 73
|
|
| PEP_synth |
TIGR01418 |
phosphoenolpyruvate synthase; Also called pyruvate,water dikinase and PEP synthase. The member ... |
467-574 |
1.66e-21 |
|
phosphoenolpyruvate synthase; Also called pyruvate,water dikinase and PEP synthase. The member from Methanococcus jannaschii contains a large intein. This enzyme generates phosphoenolpyruvate (PEP) from pyruvate, hydrolyzing ATP to AMP and releasing inorganic phosphate in the process. The enzyme shows extensive homology to other enzymes that use PEP as substrate or product. This enzyme may provide PEP for gluconeogenesis, for PTS-type carbohydrate transport systems, or for other processes. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273612 [Multi-domain] Cd Length: 786 Bit Score: 99.04 E-value: 1.66e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 467 KVHVVGDILVSGQGVNGRCAFGRLCVARTGEEAlASFNDGDILVVPQTSNELLPIMKKASGIVTERGGLNSHAAIVGMAL 546
Cdd:TIGR01418 347 ELKGKGKVLVTGRAAGPGIASGKVKVIFDLKEM-DKFEEGDILVTDMTDPDWEPAMKRASAIVTNEGGMTCHAAIVAREL 425
|
90 100
....*....|....*....|....*...
gi 493929278 547 DIPVIVFAENATSILKSSTVVEIDAAAG 574
Cdd:TIGR01418 426 GIPAVVGTGDATKTLKDGMEVTVDCAEG 453
|
|
| PRK06464 |
PRK06464 |
phosphoenolpyruvate synthase; Validated |
472-575 |
5.74e-20 |
|
phosphoenolpyruvate synthase; Validated
Pssm-ID: 235809 [Multi-domain] Cd Length: 795 Bit Score: 94.04 E-value: 5.74e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 472 GDILVSGQGVNGRCAFGRLCVARTGEEaLASFNDGDILVVPQTSNELLPIMKKASGIVTERGGLNSHAAIVGMALDIPVI 551
Cdd:PRK06464 353 GKVLVEGRAIGPGIGSGKVRVILDISE-MDKVQPGDVLVTDMTDPDWEPVMKRASAIVTNRGGRTCHAAIIARELGIPAV 431
|
90 100
....*....|....*....|....
gi 493929278 552 VFAENATSILKSSTVVEIDAAAGT 575
Cdd:PRK06464 432 VGTGNATEVLKDGQEVTVSCAEGD 455
|
|
| PRK08296 |
PRK08296 |
hypothetical protein; Provisional |
488-577 |
5.22e-13 |
|
hypothetical protein; Provisional
Pssm-ID: 181362 Cd Length: 603 Bit Score: 71.61 E-value: 5.22e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 488 GRLCVARTGEEaLASFNDGDILVVPQTSNELLPIMKKASGIVTERGGLNSHAAIVGMALDIPVIVFAENATSILKSSTVV 567
Cdd:PRK08296 512 GPARVIRSADE-LSEVQEGEILVCPVTSPSWAPIFAKIKATVTDIGGVMSHAAIVCREYGLPAVVGTGNATKRIKTGQRL 590
|
90
....*....|
gi 493929278 568 EIDAAAGTVS 577
Cdd:PRK08296 591 RVDGTKGVVT 600
|
|
| PRK06241 |
PRK06241 |
phosphoenolpyruvate synthase; Validated |
478-576 |
8.00e-12 |
|
phosphoenolpyruvate synthase; Validated
Pssm-ID: 235751 [Multi-domain] Cd Length: 871 Bit Score: 68.38 E-value: 8.00e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 478 GQGVNGRCAFGRLCVARTGEEALAsfNDGDILVVPQTSNELLPIMKKASGIVTERGGLNSHAAIVGMALDIPVIVFAENA 557
Cdd:PRK06241 770 GLPVSSGVVEGRARVILNPEDADL--EKGDILVTAFTDPGWTPLFVSIKGLVTEVGGLMTHGAVIAREYGIPAVVGVENA 847
|
90
....*....|....*....
gi 493929278 558 TSILKSSTVVEIDAAAGTV 576
Cdd:PRK06241 848 TKLIKDGQRIRVDGTEGYV 866
|
|
| PtsA |
COG1080 |
Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate ... |
497-576 |
9.13e-10 |
|
Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism];
Pssm-ID: 440698 [Multi-domain] Cd Length: 571 Bit Score: 61.25 E-value: 9.13e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 497 EEALASFNDGDILVvpqtSNELLPIM------KKASGIVTERGGLNSHAAIVGMALDIPVIVFAENATSILKSSTVVEID 570
Cdd:COG1080 145 APDLSDLPEPVILV----AHDLTPSDtaqldpSRVAGFVTDLGGRTSHTAILARSLGIPAVVGLGDALLLVKDGDLVIVD 220
|
....*.
gi 493929278 571 AAAGTV 576
Cdd:COG1080 221 GDAGVV 226
|
|
| PRK05865 |
PRK05865 |
sugar epimerase family protein; |
478-576 |
4.08e-07 |
|
sugar epimerase family protein;
Pssm-ID: 235630 [Multi-domain] Cd Length: 854 Bit Score: 53.12 E-value: 4.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493929278 478 GQGVNGRCAFGRLCVARTgeEALASFNDGDILVVPQTSNELLPIMKKASGIVTERGGLNSHAAIVGMALDIPVIVFAENA 557
Cdd:PRK05865 738 GVGVCGGRVRGRVRIVRP--ETIDDLQPGEILVAEVTDVGYTAAFCYAAAVVTELGGPMSHAAVVAREFGFPCVVDAQGA 815
|
90
....*....|....*....
gi 493929278 558 TSILKSSTVVEIDAAAGTV 576
Cdd:PRK05865 816 TRFLPPGALVEVDGATGEI 834
|
|
| PRK05878 |
PRK05878 |
pyruvate phosphate dikinase; Provisional |
498-576 |
1.18e-06 |
|
pyruvate phosphate dikinase; Provisional
Pssm-ID: 235635 [Multi-domain] Cd Length: 530 Bit Score: 51.28 E-value: 1.18e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 493929278 498 EALASFNDGDILVVPQTSNELLPIMKKASGIVTERGGLNSHAAIVGMALDIPVIVFAENATSILKSSTVVEIDAAAGTV 576
Cdd:PRK05878 373 LDAADRGEPVILVRDHTRPDDVHGMLAAQGIVTEVGGATSHAAVVSRELGRVAVVGCGAGVAAALAGKEITVDGYEGEV 451
|
|
| |
