endopeptidase La [Gordonia namibiensis]
Protein Classification
endopeptidase La( domain architecture ID 11422032)
endopeptidase La is an ATP-dependent serine protease that degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long; it binds to DNA in a double-stranded, site-specific manner
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||||||||
| Lon | COG0466 | ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, ... |
7-767 | 0e+00 | |||||||||||
ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; : Pssm-ID: 440234 [Multi-domain] Cd Length: 785 Bit Score: 1046.14 E-value: 0e+00
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| Name | Accession | Description | Interval | E-value | |||||||||||
| Lon | COG0466 | ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, ... |
7-767 | 0e+00 | |||||||||||
ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 440234 [Multi-domain] Cd Length: 785 Bit Score: 1046.14 E-value: 0e+00
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| lon | TIGR00763 | endopeptidase La; This protein, the ATP-dependent serine endopeptidase La, is induced by heat ... |
8-764 | 0e+00 | |||||||||||
endopeptidase La; This protein, the ATP-dependent serine endopeptidase La, is induced by heat shock and other stresses in E. coli, B. subtilis, and other species. The yeast member, designated PIM1, is located in the mitochondrial matrix, required for mitochondrial function, and also induced by heat shock. [Protein fate, Degradation of proteins, peptides, and glycopeptides] Pssm-ID: 273258 [Multi-domain] Cd Length: 775 Bit Score: 825.40 E-value: 0e+00
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| PRK10787 | PRK10787 | DNA-binding ATP-dependent protease La; Provisional |
2-775 | 0e+00 | |||||||||||
DNA-binding ATP-dependent protease La; Provisional Pssm-ID: 182730 [Multi-domain] Cd Length: 784 Bit Score: 627.35 E-value: 0e+00
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| Lon_C | pfam05362 | Lon protease (S16) C-terminal proteolytic domain; The Lon serine proteases must hydrolyse ATP ... |
563-766 | 1.66e-105 | |||||||||||
Lon protease (S16) C-terminal proteolytic domain; The Lon serine proteases must hydrolyse ATP to degrade protein substrates. In Escherichia coli, these proteases are involved in turnover of intracellular proteins, including abnormal proteins following heat-shock. The active site for protease activity resides in a C-terminal domain. The Lon proteases are classified as family S16 in Merops. Pssm-ID: 428442 [Multi-domain] Cd Length: 205 Bit Score: 321.50 E-value: 1.66e-105
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| RecA-like_Lon | cd19500 | lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an ... |
297-487 | 7.55e-97 | |||||||||||
lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an evolutionarily conserved ATP-dependent serine protease, present in bacteria and eukaryotic mitochondria and peroxisomes, which mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Lon protease is both an ATP-dependent peptidase and a protein-activated ATPase. This RecA-like Lon domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion. Pssm-ID: 410908 [Multi-domain] Cd Length: 182 Bit Score: 298.32 E-value: 7.55e-97
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| AAA | smart00382 | ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ... |
341-420 | 6.37e-04 | |||||||||||
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment. Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 40.82 E-value: 6.37e-04
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| Name | Accession | Description | Interval | E-value | |||||||||||
| Lon | COG0466 | ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, ... |
7-767 | 0e+00 | |||||||||||
ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 440234 [Multi-domain] Cd Length: 785 Bit Score: 1046.14 E-value: 0e+00
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| lon | TIGR00763 | endopeptidase La; This protein, the ATP-dependent serine endopeptidase La, is induced by heat ... |
8-764 | 0e+00 | |||||||||||
endopeptidase La; This protein, the ATP-dependent serine endopeptidase La, is induced by heat shock and other stresses in E. coli, B. subtilis, and other species. The yeast member, designated PIM1, is located in the mitochondrial matrix, required for mitochondrial function, and also induced by heat shock. [Protein fate, Degradation of proteins, peptides, and glycopeptides] Pssm-ID: 273258 [Multi-domain] Cd Length: 775 Bit Score: 825.40 E-value: 0e+00
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| PRK10787 | PRK10787 | DNA-binding ATP-dependent protease La; Provisional |
2-775 | 0e+00 | |||||||||||
DNA-binding ATP-dependent protease La; Provisional Pssm-ID: 182730 [Multi-domain] Cd Length: 784 Bit Score: 627.35 E-value: 0e+00
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| Lon_C | pfam05362 | Lon protease (S16) C-terminal proteolytic domain; The Lon serine proteases must hydrolyse ATP ... |
563-766 | 1.66e-105 | |||||||||||
Lon protease (S16) C-terminal proteolytic domain; The Lon serine proteases must hydrolyse ATP to degrade protein substrates. In Escherichia coli, these proteases are involved in turnover of intracellular proteins, including abnormal proteins following heat-shock. The active site for protease activity resides in a C-terminal domain. The Lon proteases are classified as family S16 in Merops. Pssm-ID: 428442 [Multi-domain] Cd Length: 205 Bit Score: 321.50 E-value: 1.66e-105
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| RecA-like_Lon | cd19500 | lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an ... |
297-487 | 7.55e-97 | |||||||||||
lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an evolutionarily conserved ATP-dependent serine protease, present in bacteria and eukaryotic mitochondria and peroxisomes, which mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Lon protease is both an ATP-dependent peptidase and a protein-activated ATPase. This RecA-like Lon domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion. Pssm-ID: 410908 [Multi-domain] Cd Length: 182 Bit Score: 298.32 E-value: 7.55e-97
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| LON_substr_bdg | pfam02190 | ATP-dependent protease La (LON) substrate-binding domain; This domain has been shown to be ... |
7-185 | 7.25e-23 | |||||||||||
ATP-dependent protease La (LON) substrate-binding domain; This domain has been shown to be part of the PUA superfamily. This domain represents a general protein and polypeptide interaction domain for the ATP-dependent serine peptidase, LON, Peptidase_S16, pfam05362. ATP-dependent Lon proteases are conserved in all living organizms and catalyze rapid turnover of short-lived regulatory proteins and many damaged or denatured proteins. Pssm-ID: 426647 [Multi-domain] Cd Length: 195 Bit Score: 97.02 E-value: 7.25e-23
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| AAA | pfam00004 | ATPase family associated with various cellular activities (AAA); AAA family proteins often ... |
345-480 | 7.32e-22 | |||||||||||
ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. Pssm-ID: 459627 [Multi-domain] Cd Length: 130 Bit Score: 91.89 E-value: 7.32e-22
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| COG1750 | COG1750 | Predicted archaeal serine protease, S18 family [General function prediction only]; |
595-760 | 1.95e-16 | |||||||||||
Predicted archaeal serine protease, S18 family [General function prediction only]; Pssm-ID: 441356 [Multi-domain] Cd Length: 213 Bit Score: 78.87 E-value: 1.95e-16
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| SpoVK | COG0464 | AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ... |
163-550 | 1.50e-14 | |||||||||||
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]; Pssm-ID: 440232 [Multi-domain] Cd Length: 397 Bit Score: 76.49 E-value: 1.50e-14
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| RecA-like_protease | cd19481 | proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ... |
314-442 | 7.33e-12 | |||||||||||
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion. Pssm-ID: 410889 [Multi-domain] Cd Length: 158 Bit Score: 64.23 E-value: 7.33e-12
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| RPT1 | COG1222 | ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ... |
310-428 | 2.77e-08 | |||||||||||
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 440835 [Multi-domain] Cd Length: 326 Bit Score: 56.17 E-value: 2.77e-08
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| COG1223 | COG1223 | Predicted ATPase, AAA+ superfamily [General function prediction only]; |
316-549 | 7.63e-08 | |||||||||||
Predicted ATPase, AAA+ superfamily [General function prediction only]; Pssm-ID: 440836 [Multi-domain] Cd Length: 246 Bit Score: 54.12 E-value: 7.63e-08
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| AAA | cd00009 | The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ... |
339-438 | 1.37e-07 | |||||||||||
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases. Pssm-ID: 99707 [Multi-domain] Cd Length: 151 Bit Score: 51.38 E-value: 1.37e-07
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| AAA_5 | pfam07728 | AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ... |
345-438 | 1.78e-07 | |||||||||||
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model. Pssm-ID: 400191 [Multi-domain] Cd Length: 135 Bit Score: 50.75 E-value: 1.78e-07
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| AAA_2 | pfam07724 | AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected ... |
347-438 | 1.07e-06 | |||||||||||
AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model. Pssm-ID: 400187 [Multi-domain] Cd Length: 168 Bit Score: 49.50 E-value: 1.07e-06
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| T7SS_EccA | TIGR03922 | type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the ... |
310-446 | 1.65e-06 | |||||||||||
type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the actinobacterial flavor of type VII secretion systems. Species such as Mycobacterium tuberculosis have several instances of this system per genome, designated EccA1, EccA2, etc. [Protein fate, Protein and peptide secretion and trafficking] Pssm-ID: 188437 [Multi-domain] Cd Length: 557 Bit Score: 51.38 E-value: 1.65e-06
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| MoxR | COG0714 | MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ... |
349-525 | 1.75e-06 | |||||||||||
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis Pssm-ID: 440478 [Multi-domain] Cd Length: 292 Bit Score: 50.55 E-value: 1.75e-06
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| McrB | COG1401 | 5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB ... |
129-437 | 2.15e-06 | |||||||||||
5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB [Defense mechanisms]; Pssm-ID: 441011 [Multi-domain] Cd Length: 477 Bit Score: 50.92 E-value: 2.15e-06
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| PRK13342 | PRK13342 | recombination factor protein RarA; Reviewed |
345-418 | 1.59e-05 | |||||||||||
recombination factor protein RarA; Reviewed Pssm-ID: 237355 [Multi-domain] Cd Length: 413 Bit Score: 48.16 E-value: 1.59e-05
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| ChlI | pfam13541 | Subunit ChlI of Mg-chelatase; |
607-733 | 1.67e-05 | |||||||||||
Subunit ChlI of Mg-chelatase; Pssm-ID: 433293 [Multi-domain] Cd Length: 121 Bit Score: 44.75 E-value: 1.67e-05
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| RecA-like_ClpB_Hsp104-like | cd19499 | Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and ... |
316-438 | 2.29e-05 | |||||||||||
Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and eukaryotic Heat shock protein 104 (Hsp104) are ATP-dependent molecular chaperones and essential proteins of the heat-shock response. ClpB/Hsp104 ATPases, in concert with the DnaK/Hsp70 chaperone system, disaggregate and reactivate aggregated proteins. This RecA-like_ClpB_Hsp104_like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion. Pssm-ID: 410907 [Multi-domain] Cd Length: 178 Bit Score: 45.63 E-value: 2.29e-05
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| SdrC | COG3480 | Predicted secreted protein YlbL, contains PDZ domain [Signal transduction mechanisms]; |
670-733 | 3.10e-05 | |||||||||||
Predicted secreted protein YlbL, contains PDZ domain [Signal transduction mechanisms]; Pssm-ID: 442703 [Multi-domain] Cd Length: 344 Bit Score: 46.73 E-value: 3.10e-05
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| RarA | COG2256 | Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ... |
345-418 | 5.24e-05 | |||||||||||
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair]; Pssm-ID: 441857 [Multi-domain] Cd Length: 439 Bit Score: 46.59 E-value: 5.24e-05
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| RecA-like_NVL_r1-like | cd19518 | first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ... |
310-423 | 9.46e-05 | |||||||||||
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion. Pssm-ID: 410926 [Multi-domain] Cd Length: 169 Bit Score: 43.55 E-value: 9.46e-05
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| PRK04195 | PRK04195 | replication factor C large subunit; Provisional |
346-442 | 5.95e-04 | |||||||||||
replication factor C large subunit; Provisional Pssm-ID: 235250 [Multi-domain] Cd Length: 482 Bit Score: 42.99 E-value: 5.95e-04
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| AAA | smart00382 | ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ... |
341-420 | 6.37e-04 | |||||||||||
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment. Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 40.82 E-value: 6.37e-04
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| RecA-like_VPS4-like | cd19509 | ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ... |
310-426 | 8.18e-04 | |||||||||||
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion. Pssm-ID: 410917 [Multi-domain] Cd Length: 163 Bit Score: 40.80 E-value: 8.18e-04
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| SK | cd00464 | Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic ... |
346-371 | 9.38e-04 | |||||||||||
Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids, p-aminobenzoic acid, folate and ubiquinone. Shikimate kinase catalyses the phosphorylation of the 3-hydroxyl group of shikimic acid using ATP. Pssm-ID: 238260 [Multi-domain] Cd Length: 154 Bit Score: 40.62 E-value: 9.38e-04
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| Sms | COG1066 | DNA repair protein RadA/Sms, contains AAA+ ATPase domain [Replication, recombination and ... |
671-764 | 9.73e-04 | |||||||||||
DNA repair protein RadA/Sms, contains AAA+ ATPase domain [Replication, recombination and repair]; Pssm-ID: 440685 [Multi-domain] Cd Length: 453 Bit Score: 42.34 E-value: 9.73e-04
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| AroK | COG0703 | Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the ... |
346-371 | 1.24e-03 | |||||||||||
Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis Pssm-ID: 440467 [Multi-domain] Cd Length: 165 Bit Score: 40.11 E-value: 1.24e-03
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| RecA-like_PAN_like | cd19502 | proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ... |
346-423 | 1.29e-03 | |||||||||||
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion. Pssm-ID: 410910 [Multi-domain] Cd Length: 171 Bit Score: 40.40 E-value: 1.29e-03
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| aroK | PRK00131 | shikimate kinase; Reviewed |
346-371 | 1.65e-03 | |||||||||||
shikimate kinase; Reviewed Pssm-ID: 234654 [Multi-domain] Cd Length: 175 Bit Score: 40.17 E-value: 1.65e-03
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| RecA-like_FtsH | cd19501 | ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ... |
306-422 | 2.60e-03 | |||||||||||
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion. Pssm-ID: 410909 [Multi-domain] Cd Length: 171 Bit Score: 39.52 E-value: 2.60e-03
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| RecA-like_Ycf46-like | cd19507 | ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ... |
310-476 | 2.68e-03 | |||||||||||
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion. Pssm-ID: 410915 [Multi-domain] Cd Length: 161 Bit Score: 39.27 E-value: 2.68e-03
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| RecA-like_CDC48_NLV2_r1-like | cd19503 | first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ... |
310-419 | 3.12e-03 | |||||||||||
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion. Pssm-ID: 410911 [Multi-domain] Cd Length: 165 Bit Score: 39.20 E-value: 3.12e-03
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| AAA_16 | pfam13191 | AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ... |
339-442 | 4.06e-03 | |||||||||||
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Pssm-ID: 433025 [Multi-domain] Cd Length: 167 Bit Score: 39.02 E-value: 4.06e-03
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| AAA_PrkA | smart00763 | PrkA AAA domain; This is a family of PrkA bacterial and archaeal serine kinases approximately ... |
302-366 | 4.33e-03 | |||||||||||
PrkA AAA domain; This is a family of PrkA bacterial and archaeal serine kinases approximately 630 residues long. This is the N-terminal AAA domain. Pssm-ID: 214810 Cd Length: 361 Bit Score: 39.97 E-value: 4.33e-03
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| hflB | PRK10733 | ATP-dependent zinc metalloprotease FtsH; |
306-422 | 4.87e-03 | |||||||||||
ATP-dependent zinc metalloprotease FtsH; Pssm-ID: 182683 [Multi-domain] Cd Length: 644 Bit Score: 40.40 E-value: 4.87e-03
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| Kti12 | COG4088 | tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) ... |
341-396 | 5.64e-03 | |||||||||||
tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) [Translation, ribosomal structure and biogenesis, Defense mechanisms]; Pssm-ID: 443264 [Multi-domain] Cd Length: 179 Bit Score: 38.55 E-value: 5.64e-03
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| TIP49 | pfam06068 | TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and ... |
310-384 | 5.74e-03 | |||||||||||
TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the pfam00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases. Pssm-ID: 399217 [Multi-domain] Cd Length: 347 Bit Score: 39.60 E-value: 5.74e-03
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| clpA | PRK11034 | ATP-dependent Clp protease ATP-binding subunit; Provisional |
346-438 | 7.93e-03 | |||||||||||
ATP-dependent Clp protease ATP-binding subunit; Provisional Pssm-ID: 236828 [Multi-domain] Cd Length: 758 Bit Score: 39.82 E-value: 7.93e-03
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| ABC_ATPase | cd00267 | ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large ... |
341-419 | 9.58e-03 | |||||||||||
ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213179 [Multi-domain] Cd Length: 157 Bit Score: 37.61 E-value: 9.58e-03
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