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Conserved domains on  [gi|493864985|ref|WP_006811691|]
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MULTISPECIES: DNA-binding protein StpA [Enterobacter]

Protein Classification

DNA-binding protein StpA( domain architecture ID 11484657)

DNA-binding protein StpA acts in a fashion similar to H-NS protein upon overexpression, repressing a number of genes including the cryptic blg operon, hns, papB and the proU locus

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10328 PRK10328
DNA-binding protein StpA;
1-134 6.92e-75

DNA-binding protein StpA;


:

Pssm-ID: 182380 [Multi-domain]  Cd Length: 134  Bit Score: 218.59  E-value: 6.92e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864985   1 MALTLQNLNNIRTLRALARELSMDVLEEVLEKFRMVTEEKRSEQAELERQRAEQQDKINALLELMKADGISPSDLLGSDL 80
Cdd:PRK10328   1 MSVMLQSLNNIRTLRAMAREFSIDVLEEMLEKFRVVTKERREEEEQQQRELAERQEKINTWLELMKADGINPEELLGNSS 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 493864985  81 AQAGQPTKKRKARAAKYRFIDANGEEKTWTGQGRTPKPIATALANGKSLDDFLI 134
Cdd:PRK10328  81 AAAPRAGKKRQPRPAKYRFTDVNGETKTWTGQGRTPKPIAQALAEGKSLDDFLI 134
 
Name Accession Description Interval E-value
PRK10328 PRK10328
DNA-binding protein StpA;
1-134 6.92e-75

DNA-binding protein StpA;


Pssm-ID: 182380 [Multi-domain]  Cd Length: 134  Bit Score: 218.59  E-value: 6.92e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864985   1 MALTLQNLNNIRTLRALARELSMDVLEEVLEKFRMVTEEKRSEQAELERQRAEQQDKINALLELMKADGISPSDLLGSDL 80
Cdd:PRK10328   1 MSVMLQSLNNIRTLRAMAREFSIDVLEEMLEKFRVVTKERREEEEQQQRELAERQEKINTWLELMKADGINPEELLGNSS 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 493864985  81 AQAGQPTKKRKARAAKYRFIDANGEEKTWTGQGRTPKPIATALANGKSLDDFLI 134
Cdd:PRK10328  81 AAAPRAGKKRQPRPAKYRFTDVNGETKTWTGQGRTPKPIAQALAEGKSLDDFLI 134
Hns COG2916
DNA-binding protein H-NS [Transcription];
18-134 3.10e-31

DNA-binding protein H-NS [Transcription];


Pssm-ID: 442160 [Multi-domain]  Cd Length: 109  Bit Score: 107.28  E-value: 3.10e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864985  18 ARELSMDVLEEVLEKFrmvteekrsEQAELERQRAEQQDKINALLELMKADGISPSDLLGSdlAQAGQPTKKRKARAAKY 97
Cdd:COG2916    5 LRELSLEELEELIEKL---------EKVIEELEKRERAEALAEIKELAAEYGISLEELLGA--LAAKKAKKKRAKVPAKY 73

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 493864985  98 RfiDANGEEKTWTGQGRTPKPIATALANGKSLDDFLI 134
Cdd:COG2916   74 R--DPNGPGKTWTGRGRKPKWIKAALAAGKSLEDFLI 108
Histone_HNS pfam00816
H-NS histone family;
39-128 6.83e-23

H-NS histone family;


Pssm-ID: 425884 [Multi-domain]  Cd Length: 91  Bit Score: 85.40  E-value: 6.83e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864985   39 EKRSEQAElERQRAEQQDKINALLELMKADGISPSDLLGSdLAQAGQPTKKRKARAAKYRfiDANGEEKTWTGQGRTPKP 118
Cdd:pfam00816   6 AELEKEIE-ALRKRERKEVLAQIRELAAEYGLTLEELGGA-AKAARKAKAKAAKVPAKYR--DPATPGETWTGRGRKPKW 81

                          90
                  ....*....|
gi 493864985  119 IATALANGKS 128
Cdd:pfam00816  82 IKAALAAGKS 91
HNS smart00528
Domain in histone-like proteins of HNS family;
87-134 7.71e-19

Domain in histone-like proteins of HNS family;


Pssm-ID: 128801  Cd Length: 46  Bit Score: 74.00  E-value: 7.71e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 493864985    87 TKKRKARAAKYRFIDANGEekTWTGQGRTPKPIATALANGKSLDDFLI 134
Cdd:smart00528   1 KKKRAARPAKYRYPDNNGE--TWSGRGRTPRWLAAALDSGKSLEDFLI 46
 
Name Accession Description Interval E-value
PRK10328 PRK10328
DNA-binding protein StpA;
1-134 6.92e-75

DNA-binding protein StpA;


Pssm-ID: 182380 [Multi-domain]  Cd Length: 134  Bit Score: 218.59  E-value: 6.92e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864985   1 MALTLQNLNNIRTLRALARELSMDVLEEVLEKFRMVTEEKRSEQAELERQRAEQQDKINALLELMKADGISPSDLLGSDL 80
Cdd:PRK10328   1 MSVMLQSLNNIRTLRAMAREFSIDVLEEMLEKFRVVTKERREEEEQQQRELAERQEKINTWLELMKADGINPEELLGNSS 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 493864985  81 AQAGQPTKKRKARAAKYRFIDANGEEKTWTGQGRTPKPIATALANGKSLDDFLI 134
Cdd:PRK10328  81 AAAPRAGKKRQPRPAKYRFTDVNGETKTWTGQGRTPKPIAQALAEGKSLDDFLI 134
PRK10947 PRK10947
DNA-binding transcriptional regulator H-NS;
1-134 1.01e-37

DNA-binding transcriptional regulator H-NS;


Pssm-ID: 182858  Cd Length: 135  Bit Score: 124.64  E-value: 1.01e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864985   1 MALTLQNLNNIRTLRALARELSMDVLEEVLEKFRMVTEEKRSEQAELERQRAEQQDKINALLELMKADGISPSDLLGSdL 80
Cdd:PRK10947   1 MSEALKILNNIRTLRAQARECTLETLEEMLEKLEVVVNERREEESAAAAEVEERTRKLQQYREMLIADGIDPNELLNS-L 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 493864985  81 AQAGQPTK-KRKARAAKYRFIDANGEEKTWTGQGRTPKPIATALAN-GKSLDDFLI 134
Cdd:PRK10947  80 AAVKSGTKaKRAARPAKYSYVDENGETKTWTGQGRTPAVIKKAMDEqGKSLDDFLI 135
Hns COG2916
DNA-binding protein H-NS [Transcription];
18-134 3.10e-31

DNA-binding protein H-NS [Transcription];


Pssm-ID: 442160 [Multi-domain]  Cd Length: 109  Bit Score: 107.28  E-value: 3.10e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864985  18 ARELSMDVLEEVLEKFrmvteekrsEQAELERQRAEQQDKINALLELMKADGISPSDLLGSdlAQAGQPTKKRKARAAKY 97
Cdd:COG2916    5 LRELSLEELEELIEKL---------EKVIEELEKRERAEALAEIKELAAEYGISLEELLGA--LAAKKAKKKRAKVPAKY 73

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 493864985  98 RfiDANGEEKTWTGQGRTPKPIATALANGKSLDDFLI 134
Cdd:COG2916   74 R--DPNGPGKTWTGRGRKPKWIKAALAAGKSLEDFLI 108
Histone_HNS pfam00816
H-NS histone family;
39-128 6.83e-23

H-NS histone family;


Pssm-ID: 425884 [Multi-domain]  Cd Length: 91  Bit Score: 85.40  E-value: 6.83e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493864985   39 EKRSEQAElERQRAEQQDKINALLELMKADGISPSDLLGSdLAQAGQPTKKRKARAAKYRfiDANGEEKTWTGQGRTPKP 118
Cdd:pfam00816   6 AELEKEIE-ALRKRERKEVLAQIRELAAEYGLTLEELGGA-AKAARKAKAKAAKVPAKYR--DPATPGETWTGRGRKPKW 81

                          90
                  ....*....|
gi 493864985  119 IATALANGKS 128
Cdd:pfam00816  82 IKAALAAGKS 91
HNS smart00528
Domain in histone-like proteins of HNS family;
87-134 7.71e-19

Domain in histone-like proteins of HNS family;


Pssm-ID: 128801  Cd Length: 46  Bit Score: 74.00  E-value: 7.71e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 493864985    87 TKKRKARAAKYRFIDANGEekTWTGQGRTPKPIATALANGKSLDDFLI 134
Cdd:smart00528   1 KKKRAARPAKYRYPDNNGE--TWSGRGRTPRWLAAALDSGKSLEDFLI 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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