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Conserved domains on  [gi|493474997|ref|WP_006429992|]
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acetate--CoA ligase family protein [Natrinema versiforme]

Protein Classification

acetate--CoA ligase family protein( domain architecture ID 11437147)

acetate--CoA ligase family protein similar to ADP-forming acetate--CoA ligase that catalyzes the formation of acetate and ATP from acetyl-CoA by using ADP and phosphate

CATH:  3.30.1490.20
EC:  6.2.1.-
Gene Ontology:  GO:0043758|GO:0005524|GO:0046872
PubMed:  15491124|15316652
SCOP:  3000003

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PatZN COG1042
Acyl-CoA synthetase (NDP forming) [Energy production and conversion];
3-702 0e+00

Acyl-CoA synthetase (NDP forming) [Energy production and conversion];


:

Pssm-ID: 440664 [Multi-domain]  Cd Length: 708  Bit Score: 834.39  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997   3 RLSALFDPETVAVVGATDREGAVGRAILENLRD-GFAGEVVPINPSREAVLGLECYEDATSAP-PIDLAVVVVPPDIVIE 80
Cdd:COG1042    5 SLDALFRPRSVAVIGASDRPGKVGGRVLRNLLEgGFKGKIYPVNPKYDEVLGLPCYPSVADLPePPDLAVIAVPAETVPD 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997  81 SMRNLAAAGTENVVVITAGFAETGGEGAQRERQLREIAAEYDLNVVGPNSLGIMATSTGMNATFGPEDALEGSISFMSQS 160
Cdd:COG1042   85 VVEECGEKGVKAAVVISAGFAETGEEGAALEQELLEIARRYGMRLLGPNCLGLINPATGLNATFAPVPPLPGNIALVSQS 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997 161 GAFITAVLDWANEQGIGFRDVVSLGNKTVLDETDFVREWGDDPETDVIIGYLEDIDDGRGFIDAAREVTDDTPIVLVKSG 240
Cdd:COG1042  165 GALGTAILDWAAARGIGFSHFVSLGNEADVDFADLLDYLADDPDTRVILLYLEGIRDGRRFLSAARAAARGKPVVVLKSG 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997 241 RTDAGAQAASSHTGAIAGSERAYEAGLEQAGVLRARSVQELFDYARALSGLPEPESDGVAVVTNAGGPGVLTTDAVGDST 320
Cdd:COG1042  245 RSEAGARAAASHTGALAGSDAVYDAAFRRAGVIRVDDLEELFDAAEALARQPPPRGRRLAIVTNSGGPGVLAADALEDLG 324

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997 321 LEMADFADETIDRLGEAMPDEANVYNPIDAIGDADVERFGEALEIALADPNVGSAVVVAAPTAVLSYDDLAETVIERLEA 400
Cdd:COG1042  325 LELAELSEETQAALRAVLPPFASVGNPVDITGDADPERYAAALEALLADPNVDAVLVILTPTAMTDPEEVAEALIEAAKG 404

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997 401 HDTPVVTCLMGGERARNAEKTLRESGVPNYFDPSRAVSGLDALARYRDIRDRTVKRP--ETFDVDRERAREILARTKRRT 478
Cdd:COG1042  405 SGKPVLASWMGGDSVAEARRLLREAGIPTFRTPERAVRALAALVRYRRNQERLMETPasEDFDPDRERARAIIEAALAEG 484

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997 479 DNRL-GVESMDLLEAYGIPTPDGEIVDDPDRAREVAASIAGDVVMKIVSPDISHKSDIGGVKVGVADED-VYDAYEDVVA 556
Cdd:COG1042  485 RGVLtEAEAKALLAAYGIPVVPTRLARSAEEAVAAAEEIGYPVVLKIVSPDILHKSDVGGVRLNLRDAEaVRAAFEEILA 564

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997 557 RARNYQPDATITGVQIQEMLDleSSTETIVGMNRDPQFgplllyglggIFVEILEDTSVRVAPIDEGEAHEMVDEITAAP 636
Cdd:COG1042  565 RVRAARPDARIDGVLVQPMVP--GGVELIVGVKRDPVFgpvimfglggIFVEVLKDVALRLPPLNEALAREMIRELRAAK 642

                        650       660       670       680       690       700
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 493474997 637 LLRGARGREPADVDDVVETIQRLSQLVTDFPSILELDINPLVAGPDGVQAIDLRLTVDADELDTEE 702
Cdd:COG1042  643 LLRGYRGRPPADLDALADVLVRLSQLAADLPEILELDINPLLVVPEGVVAVDARIRLAPPAPPAPR 708
 
Name Accession Description Interval E-value
PatZN COG1042
Acyl-CoA synthetase (NDP forming) [Energy production and conversion];
3-702 0e+00

Acyl-CoA synthetase (NDP forming) [Energy production and conversion];


Pssm-ID: 440664 [Multi-domain]  Cd Length: 708  Bit Score: 834.39  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997   3 RLSALFDPETVAVVGATDREGAVGRAILENLRD-GFAGEVVPINPSREAVLGLECYEDATSAP-PIDLAVVVVPPDIVIE 80
Cdd:COG1042    5 SLDALFRPRSVAVIGASDRPGKVGGRVLRNLLEgGFKGKIYPVNPKYDEVLGLPCYPSVADLPePPDLAVIAVPAETVPD 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997  81 SMRNLAAAGTENVVVITAGFAETGGEGAQRERQLREIAAEYDLNVVGPNSLGIMATSTGMNATFGPEDALEGSISFMSQS 160
Cdd:COG1042   85 VVEECGEKGVKAAVVISAGFAETGEEGAALEQELLEIARRYGMRLLGPNCLGLINPATGLNATFAPVPPLPGNIALVSQS 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997 161 GAFITAVLDWANEQGIGFRDVVSLGNKTVLDETDFVREWGDDPETDVIIGYLEDIDDGRGFIDAAREVTDDTPIVLVKSG 240
Cdd:COG1042  165 GALGTAILDWAAARGIGFSHFVSLGNEADVDFADLLDYLADDPDTRVILLYLEGIRDGRRFLSAARAAARGKPVVVLKSG 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997 241 RTDAGAQAASSHTGAIAGSERAYEAGLEQAGVLRARSVQELFDYARALSGLPEPESDGVAVVTNAGGPGVLTTDAVGDST 320
Cdd:COG1042  245 RSEAGARAAASHTGALAGSDAVYDAAFRRAGVIRVDDLEELFDAAEALARQPPPRGRRLAIVTNSGGPGVLAADALEDLG 324

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997 321 LEMADFADETIDRLGEAMPDEANVYNPIDAIGDADVERFGEALEIALADPNVGSAVVVAAPTAVLSYDDLAETVIERLEA 400
Cdd:COG1042  325 LELAELSEETQAALRAVLPPFASVGNPVDITGDADPERYAAALEALLADPNVDAVLVILTPTAMTDPEEVAEALIEAAKG 404

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997 401 HDTPVVTCLMGGERARNAEKTLRESGVPNYFDPSRAVSGLDALARYRDIRDRTVKRP--ETFDVDRERAREILARTKRRT 478
Cdd:COG1042  405 SGKPVLASWMGGDSVAEARRLLREAGIPTFRTPERAVRALAALVRYRRNQERLMETPasEDFDPDRERARAIIEAALAEG 484

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997 479 DNRL-GVESMDLLEAYGIPTPDGEIVDDPDRAREVAASIAGDVVMKIVSPDISHKSDIGGVKVGVADED-VYDAYEDVVA 556
Cdd:COG1042  485 RGVLtEAEAKALLAAYGIPVVPTRLARSAEEAVAAAEEIGYPVVLKIVSPDILHKSDVGGVRLNLRDAEaVRAAFEEILA 564

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997 557 RARNYQPDATITGVQIQEMLDleSSTETIVGMNRDPQFgplllyglggIFVEILEDTSVRVAPIDEGEAHEMVDEITAAP 636
Cdd:COG1042  565 RVRAARPDARIDGVLVQPMVP--GGVELIVGVKRDPVFgpvimfglggIFVEVLKDVALRLPPLNEALAREMIRELRAAK 642

                        650       660       670       680       690       700
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 493474997 637 LLRGARGREPADVDDVVETIQRLSQLVTDFPSILELDINPLVAGPDGVQAIDLRLTVDADELDTEE 702
Cdd:COG1042  643 LLRGYRGRPPADLDALADVLVRLSQLAADLPEILELDINPLLVVPEGVVAVDARIRLAPPAPPAPR 708
AcCoA-syn-alpha TIGR02717
acetyl coenzyme A synthetase (ADP forming), alpha domain; Although technically reversible, it ...
 4-447 0e+00

acetyl coenzyme A synthetase (ADP forming), alpha domain; Although technically reversible, it is believed that this group of ADP-dependent acetyl-CoA synthetases (ACS) act in the direction of acetate and ATP production in the organisms in which it has been characterized. In most species this protein exists as a fused alpha-beta domain polypeptide. In Pyrococcus and related species, however the domains exist as separate polypeptides. This model represents the alpha (N-terminal) domain. In Pyrococcus and related species there appears to have been the development of a paralogous family such that four other proteins are close relatives. In reference, one of these (along with its beta-domain partner) was characterized as ACS-II showing specificity for phenylacetyl-CoA. This model has been constructed to exclude these non-ACS-I paralogs. This may result in new, authentic ACS-I sequences falling below the trusted cutoff.


Pssm-ID: 131764 [Multi-domain]  Cd Length: 447  Bit Score: 538.43  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997    4 LSALFDPETVAVVGATDREGAVGRAILENLRD-GFAGEVVPINPSREAVLGLECYEDATSAP-PIDLAVVVVPPDIVIES 81
Cdd:TIGR02717   1 LEHLFNPKSVAVIGASRDPGKVGYAIMKNLIEgGYKGKIYPVNPKAGEILGVKAYPSVLEIPdPVDLAVIVVPAKYVPQV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997   82 MRNLAAAGTENVVVITAGFAETGGEGAQRERQLREIAAEYDLNVVGPNSLGIMATSTGMNATFGPEDALEGSISFMSQSG 161
Cdd:TIGR02717  81 VEECGEKGVKGAVVITAGFKEVGEEGAELEQELVEIARKYGMRLLGPNCLGIINTHIKLNATFAPTMPKKGGIAFISQSG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997  162 AFITAVLDWANEQGIGFRDVVSLGNKTVLDETDFVREWGDDPETDVIIGYLEDIDDGRGFIDAAREVTDDTPIVLVKSGR 241
Cdd:TIGR02717 161 ALLTALLDWAEKNGVGFSYFVSLGNKADIDESDLLEYLADDPDTKVILLYLEGIKDGRKFLKTAREISKKKPIVVLKSGT 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997  242 TDAGAQAASSHTGAIAGSERAYEAGLEQAGVLRARSVQELFDYARALSGLPEPESDGVAVVTNAGGPGVLTTDAVGDSTL 321
Cdd:TIGR02717 241 SEAGAKAASSHTGALAGSDEAYDAAFKQAGVIRADSIEELFDLARLLSNQPLPKGNRVAIITNAGGPGVIATDACEENGL 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997  322 EMADFADETIDRLGEAMPDEANVYNPIDAIGDADVERFGEALEIALADPNVGSAVVVAAPTAVLSYDDLAETVIE-RLEA 400
Cdd:TIGR02717 321 ELAELSEATKNKLRNILPPEASIKNPVDVLGDATPERYAKALKTVAEDENVDGVVVVLTPTAMTDPEEVAKGIIEgAKKS 400

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 493474997  401 HDTPVVTCLMGGERARNAEKTLRESGVPNYFDPSRAVSGLDALARYR 447
Cdd:TIGR02717 401 NEKPVVAGFMGGKSVDPAKRILEENGIPNYTFPERAVKALSALYRYA 447
ATP-grasp_5 pfam13549
ATP-grasp domain; This family includes a diverse set of enzymes that possess ATP-dependent ...
 472-693 6.91e-79

ATP-grasp domain; This family includes a diverse set of enzymes that possess ATP-dependent carboxylate-amine ligase activity.


Pssm-ID: 463918 [Multi-domain]  Cd Length: 221  Bit Score: 250.86  E-value: 6.91e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997  472 ARTKRRTdNRLGVESMDLLEAYGIPTPDGEIVDDPDRAREVAASIAGDVVMKIVSPDISHKSDIGGVKVGVAD-EDVYDA 550
Cdd:pfam13549   2 ALAEGRT-VLTEPEAKALLAAYGIPVVPTRLARSPEEAVAAAEEIGYPVVLKIVSPDILHKSDVGGVRLNLRSaEAVRAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997  551 YEDVVARARNYQPDATITGVQIQEMLdlESSTETIVGMNRDPQFGPLLLYGLGGIFVEILEDTSVRVAPIDEGEAHEMVD 630
Cdd:pfam13549  81 YEEILERVRRYRPDARIEGVLVQPMA--PGGRELIVGVTRDPQFGPVIMFGLGGIAVEVLKDVAFRLPPLNMTLAREMIR 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 493474997  631 EITAAPLLRGARGREPADVDDVVETIQRLSQLVTDFPSILELDINPLVAGPDGVQAIDLRLTV 693
Cdd:pfam13549 159 RTRAYKLLKGYRGEPPADLDALEDVLVRVSQLVIDFPEIRELDINPLLADEDGVVALDARIRL 221
CoA_binding smart00881
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 7-100 5.54e-11

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 214881 [Multi-domain]  Cd Length: 100  Bit Score: 59.45  E-value: 5.54e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997     7 LFDPET-VAVVGATDREGAVGRAILENLRDG---FAGEVVP--INPSreaVLGLECYEDATSAP---PIDLAVVVVPPDI 77
Cdd:smart00881   1 LLNPNTsVAVVGASGNLGSFGLAVMRNLLEYgtkFVGGVYPgkVGPK---VDGVPVYDSVAEAPeetGVDVAVIFVPAEA 77

                           90       100
                   ....*....|....*....|...
gi 493474997    78 VIESMRNLAAAGTENVVVITAGF 100
Cdd:smart00881  78 APDAIDEAIEAGIKGIVVITEGI 100
sucC PRK00696
ADP-forming succinate--CoA ligase subunit beta;
488-550 6.41e-05

ADP-forming succinate--CoA ligase subunit beta;


Pssm-ID: 234813 [Multi-domain]  Cd Length: 388  Bit Score: 45.85  E-value: 6.41e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 493474997 488 DLLEAYGIPTPDGEIVDDPDRAREVAASIAGDVVMkiVspdishKSDI--------GGVKVGVADEDVYDA 550
Cdd:PRK00696  10 ELFAKYGVPVPRGIVATTPEEAVEAAEELGGGVWV--V------KAQVhaggrgkaGGVKLAKSPEEAREF 72
 
Name Accession Description Interval E-value
PatZN COG1042
Acyl-CoA synthetase (NDP forming) [Energy production and conversion];
3-702 0e+00

Acyl-CoA synthetase (NDP forming) [Energy production and conversion];


Pssm-ID: 440664 [Multi-domain]  Cd Length: 708  Bit Score: 834.39  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997   3 RLSALFDPETVAVVGATDREGAVGRAILENLRD-GFAGEVVPINPSREAVLGLECYEDATSAP-PIDLAVVVVPPDIVIE 80
Cdd:COG1042    5 SLDALFRPRSVAVIGASDRPGKVGGRVLRNLLEgGFKGKIYPVNPKYDEVLGLPCYPSVADLPePPDLAVIAVPAETVPD 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997  81 SMRNLAAAGTENVVVITAGFAETGGEGAQRERQLREIAAEYDLNVVGPNSLGIMATSTGMNATFGPEDALEGSISFMSQS 160
Cdd:COG1042   85 VVEECGEKGVKAAVVISAGFAETGEEGAALEQELLEIARRYGMRLLGPNCLGLINPATGLNATFAPVPPLPGNIALVSQS 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997 161 GAFITAVLDWANEQGIGFRDVVSLGNKTVLDETDFVREWGDDPETDVIIGYLEDIDDGRGFIDAAREVTDDTPIVLVKSG 240
Cdd:COG1042  165 GALGTAILDWAAARGIGFSHFVSLGNEADVDFADLLDYLADDPDTRVILLYLEGIRDGRRFLSAARAAARGKPVVVLKSG 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997 241 RTDAGAQAASSHTGAIAGSERAYEAGLEQAGVLRARSVQELFDYARALSGLPEPESDGVAVVTNAGGPGVLTTDAVGDST 320
Cdd:COG1042  245 RSEAGARAAASHTGALAGSDAVYDAAFRRAGVIRVDDLEELFDAAEALARQPPPRGRRLAIVTNSGGPGVLAADALEDLG 324

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997 321 LEMADFADETIDRLGEAMPDEANVYNPIDAIGDADVERFGEALEIALADPNVGSAVVVAAPTAVLSYDDLAETVIERLEA 400
Cdd:COG1042  325 LELAELSEETQAALRAVLPPFASVGNPVDITGDADPERYAAALEALLADPNVDAVLVILTPTAMTDPEEVAEALIEAAKG 404

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997 401 HDTPVVTCLMGGERARNAEKTLRESGVPNYFDPSRAVSGLDALARYRDIRDRTVKRP--ETFDVDRERAREILARTKRRT 478
Cdd:COG1042  405 SGKPVLASWMGGDSVAEARRLLREAGIPTFRTPERAVRALAALVRYRRNQERLMETPasEDFDPDRERARAIIEAALAEG 484

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997 479 DNRL-GVESMDLLEAYGIPTPDGEIVDDPDRAREVAASIAGDVVMKIVSPDISHKSDIGGVKVGVADED-VYDAYEDVVA 556
Cdd:COG1042  485 RGVLtEAEAKALLAAYGIPVVPTRLARSAEEAVAAAEEIGYPVVLKIVSPDILHKSDVGGVRLNLRDAEaVRAAFEEILA 564

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997 557 RARNYQPDATITGVQIQEMLDleSSTETIVGMNRDPQFgplllyglggIFVEILEDTSVRVAPIDEGEAHEMVDEITAAP 636
Cdd:COG1042  565 RVRAARPDARIDGVLVQPMVP--GGVELIVGVKRDPVFgpvimfglggIFVEVLKDVALRLPPLNEALAREMIRELRAAK 642

                        650       660       670       680       690       700
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 493474997 637 LLRGARGREPADVDDVVETIQRLSQLVTDFPSILELDINPLVAGPDGVQAIDLRLTVDADELDTEE 702
Cdd:COG1042  643 LLRGYRGRPPADLDALADVLVRLSQLAADLPEILELDINPLLVVPEGVVAVDARIRLAPPAPPAPR 708
AcCoA-syn-alpha TIGR02717
acetyl coenzyme A synthetase (ADP forming), alpha domain; Although technically reversible, it ...
 4-447 0e+00

acetyl coenzyme A synthetase (ADP forming), alpha domain; Although technically reversible, it is believed that this group of ADP-dependent acetyl-CoA synthetases (ACS) act in the direction of acetate and ATP production in the organisms in which it has been characterized. In most species this protein exists as a fused alpha-beta domain polypeptide. In Pyrococcus and related species, however the domains exist as separate polypeptides. This model represents the alpha (N-terminal) domain. In Pyrococcus and related species there appears to have been the development of a paralogous family such that four other proteins are close relatives. In reference, one of these (along with its beta-domain partner) was characterized as ACS-II showing specificity for phenylacetyl-CoA. This model has been constructed to exclude these non-ACS-I paralogs. This may result in new, authentic ACS-I sequences falling below the trusted cutoff.


Pssm-ID: 131764 [Multi-domain]  Cd Length: 447  Bit Score: 538.43  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997    4 LSALFDPETVAVVGATDREGAVGRAILENLRD-GFAGEVVPINPSREAVLGLECYEDATSAP-PIDLAVVVVPPDIVIES 81
Cdd:TIGR02717   1 LEHLFNPKSVAVIGASRDPGKVGYAIMKNLIEgGYKGKIYPVNPKAGEILGVKAYPSVLEIPdPVDLAVIVVPAKYVPQV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997   82 MRNLAAAGTENVVVITAGFAETGGEGAQRERQLREIAAEYDLNVVGPNSLGIMATSTGMNATFGPEDALEGSISFMSQSG 161
Cdd:TIGR02717  81 VEECGEKGVKGAVVITAGFKEVGEEGAELEQELVEIARKYGMRLLGPNCLGIINTHIKLNATFAPTMPKKGGIAFISQSG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997  162 AFITAVLDWANEQGIGFRDVVSLGNKTVLDETDFVREWGDDPETDVIIGYLEDIDDGRGFIDAAREVTDDTPIVLVKSGR 241
Cdd:TIGR02717 161 ALLTALLDWAEKNGVGFSYFVSLGNKADIDESDLLEYLADDPDTKVILLYLEGIKDGRKFLKTAREISKKKPIVVLKSGT 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997  242 TDAGAQAASSHTGAIAGSERAYEAGLEQAGVLRARSVQELFDYARALSGLPEPESDGVAVVTNAGGPGVLTTDAVGDSTL 321
Cdd:TIGR02717 241 SEAGAKAASSHTGALAGSDEAYDAAFKQAGVIRADSIEELFDLARLLSNQPLPKGNRVAIITNAGGPGVIATDACEENGL 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997  322 EMADFADETIDRLGEAMPDEANVYNPIDAIGDADVERFGEALEIALADPNVGSAVVVAAPTAVLSYDDLAETVIE-RLEA 400
Cdd:TIGR02717 321 ELAELSEATKNKLRNILPPEASIKNPVDVLGDATPERYAKALKTVAEDENVDGVVVVLTPTAMTDPEEVAKGIIEgAKKS 400

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 493474997  401 HDTPVVTCLMGGERARNAEKTLRESGVPNYFDPSRAVSGLDALARYR 447
Cdd:TIGR02717 401 NEKPVVAGFMGGKSVDPAKRILEENGIPNYTFPERAVKALSALYRYA 447
ATP-grasp_5 pfam13549
ATP-grasp domain; This family includes a diverse set of enzymes that possess ATP-dependent ...
 472-693 6.91e-79

ATP-grasp domain; This family includes a diverse set of enzymes that possess ATP-dependent carboxylate-amine ligase activity.


Pssm-ID: 463918 [Multi-domain]  Cd Length: 221  Bit Score: 250.86  E-value: 6.91e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997  472 ARTKRRTdNRLGVESMDLLEAYGIPTPDGEIVDDPDRAREVAASIAGDVVMKIVSPDISHKSDIGGVKVGVAD-EDVYDA 550
Cdd:pfam13549   2 ALAEGRT-VLTEPEAKALLAAYGIPVVPTRLARSPEEAVAAAEEIGYPVVLKIVSPDILHKSDVGGVRLNLRSaEAVRAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997  551 YEDVVARARNYQPDATITGVQIQEMLdlESSTETIVGMNRDPQFGPLLLYGLGGIFVEILEDTSVRVAPIDEGEAHEMVD 630
Cdd:pfam13549  81 YEEILERVRRYRPDARIEGVLVQPMA--PGGRELIVGVTRDPQFGPVIMFGLGGIAVEVLKDVAFRLPPLNMTLAREMIR 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 493474997  631 EITAAPLLRGARGREPADVDDVVETIQRLSQLVTDFPSILELDINPLVAGPDGVQAIDLRLTV 693
Cdd:pfam13549 159 RTRAYKLLKGYRGEPPADLDALEDVLVRVSQLVIDFPEIRELDINPLLADEDGVVALDARIRL 221
Succ_CoA_lig pfam13607
Succinyl-CoA ligase like flavodoxin domain; This domain contains the catalytic domain from ...
 152-288 3.39e-59

Succinyl-CoA ligase like flavodoxin domain; This domain contains the catalytic domain from Succinyl-CoA ligase alpha subunit and other related enzymes. A conserved histidine is involved in phosphoryl transfer.


Pssm-ID: 433345 [Multi-domain]  Cd Length: 138  Bit Score: 195.76  E-value: 3.39e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997  152 GSISFMSQSGAFITAVLDWANEQGIGFRDVVSLGNKTVLDETDFVREWGDDPETDVIIGYLEDIDDGRGFIDAAREVTDD 231
Cdd:pfam13607   2 GNIALVSQSGALGAALLDWARSRGIGFSKFVSLGNEADVDFADLLEYLADDPETRVILLYLEGIRDGRRFLRAARRAARR 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 493474997  232 TPIVLVKSGRTDAGAQAASSHTGAIAGSERAYEAGLEQAGVLRARSVQELFDYARAL 288
Cdd:pfam13607  82 KPVVVLKAGRSEAGARAAASHTGALAGSDAVYDAAFRQAGVIRVDDLEELFDAAEAL 138
CoA_binding_2 pfam13380
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 12-134 9.60e-14

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 433162 [Multi-domain]  Cd Length: 116  Bit Score: 67.95  E-value: 9.60e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997   12 TVAVVGATDREGAVGRAILENLRD-GFagEVVPINPSREAVLGLECYED-ATSAPPIDLAVVVVPPDIVIESMRNLAAAG 89
Cdd:pfam13380   2 TIAVVGASPNPGRPGYKVARYLLEhGY--PVIPVNPKAKEILGEPVYPSlADPPEPVDLVDVFRPPEAVPEIVEEALALG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 493474997   90 TENVVVITAGFAEtggegaqrerQLREIAAEYDLNVVGPNSLGIM 134
Cdd:pfam13380  80 AKAVWLQPGIENE----------EAAAIARAAGIRVVGDRCLGVE 114
CoA_binding smart00881
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 7-100 5.54e-11

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 214881 [Multi-domain]  Cd Length: 100  Bit Score: 59.45  E-value: 5.54e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997     7 LFDPET-VAVVGATDREGAVGRAILENLRDG---FAGEVVP--INPSreaVLGLECYEDATSAP---PIDLAVVVVPPDI 77
Cdd:smart00881   1 LLNPNTsVAVVGASGNLGSFGLAVMRNLLEYgtkFVGGVYPgkVGPK---VDGVPVYDSVAEAPeetGVDVAVIFVPAEA 77

                           90       100
                   ....*....|....*....|...
gi 493474997    78 VIESMRNLAAAGTENVVVITAGF 100
Cdd:smart00881  78 APDAIDEAIEAGIKGIVVITEGI 100
Ligase_CoA_2 pfam19045
Ligase-CoA domain; This domain is related to pfam00549 and adopts a flavodoxin fold.
 299-446 4.27e-07

Ligase-CoA domain; This domain is related to pfam00549 and adopts a flavodoxin fold.


Pssm-ID: 408815  Cd Length: 162  Bit Score: 50.34  E-value: 4.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997  299 VAVVTNAGGPGVLTTDAVGDSTLEMADFADETIDRLGEAMPDEANVYNPIDAIGDADVERFGEALEIALADPNVGSAVVV 378
Cdd:pfam19045   1 VVIITGAGGSGVLLSDACVDNGLTLMAIPPDLDAAFRKFIPPFGAAGNPVDITGGEPPSTYEATIRLGLEDPRIHALILG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 493474997  379 ---AAPTAVLSYDDLAETVIE--RLEAHDTPVVTCLMGGERARNAEKTLRESGVPNY-FDPSRAVSGLDALARY 446
Cdd:pfam19045  81 ywhTIVTPPMVFAELMVRVVEemRAKGIDKPVVASLAGDVEVEEAAEYLFQHGIVAYpYTTEKPVAVLGAKYRW 154
SucD COG0074
Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA ...
 86-281 1.51e-06

Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA synthetase, alpha subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 439844 [Multi-domain]  Cd Length: 288  Bit Score: 50.44  E-value: 1.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997  86 AAAGTENVVVITagfaetggEG--AQRERQLREIAAEYDLNVVGPNSLGIMATSTGMNATFGPEDALEGSISFMSQSGAF 163
Cdd:COG0074   85 IDAGIKLIVCIT--------EGipVLDMVRVKRYAKAKGTRLIGPNCPGIITPGECKLGIMPGHIFKPGRVGIVSRSGTL 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997 164 ITAVLDWANEQGIGFRDVVSLGNKTV--LDETDFVREWGDDPETDVII------GYLEdiddgrgfIDAAREVTD--DTP 233
Cdd:COG0074  157 TYEAVWQLTQAGLGQSTCVGIGGDPIigTSFIDVLELFEEDPETEAIVmigeigGSAE--------EEAAEYIKEnmTKP 228

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 493474997 234 IVLVKSGRT--------DAGAQAASShtgaiAGSERAYEAGLEQAGVLRARSVQEL 281
Cdd:COG0074  229 VVAYIAGRTappgkrmgHAGAIISGG-----KGTAESKIEALEAAGVPVAESPSEI 279
ATP-grasp_2 pfam08442
ATP-grasp domain;
485-678 6.00e-06

ATP-grasp domain;


Pssm-ID: 400651 [Multi-domain]  Cd Length: 202  Bit Score: 47.64  E-value: 6.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997  485 ESMDLLEAYGIPTPDGEIVDDPDRAREVAASIAGDVVMKivspdishKSDI--------GGVKVGVADEDVYDAYEDVV- 555
Cdd:pfam08442   6 QAKEIFAKYGIPVPRGEVATSPEEAEEIAKKLGGKVYVV--------KAQVlaggrgkaGGVKLAKSPEEAKEVAKEMLg 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997  556 ARARNYQPDA---TITGVQIQEMLDLESstETIVG--MNRDPQfgplllyGLGGIF-----VEILE------DTSVRVA- 618
Cdd:pfam08442  78 KNLVTKQTGPdgqPVNKVLVEEALDIKK--EYYLSivLDRASK-------GPVIIAsteggVDIEEvaaknpEKIHKFPi 148

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 493474997  619 ----PIDEGEAHEMVDEItaapllrgarGREPADVDDVVETIQRLSQLVTDFPSILeLDINPLV 678
Cdd:pfam08442 149 dplkGLTPYQAREIAFKL----------GLPGELIKQAADIIKKLYKLFVEYDATL-VEINPLV 201
sucC PRK00696
ADP-forming succinate--CoA ligase subunit beta;
488-550 6.41e-05

ADP-forming succinate--CoA ligase subunit beta;


Pssm-ID: 234813 [Multi-domain]  Cd Length: 388  Bit Score: 45.85  E-value: 6.41e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 493474997 488 DLLEAYGIPTPDGEIVDDPDRAREVAASIAGDVVMkiVspdishKSDI--------GGVKVGVADEDVYDA 550
Cdd:PRK00696  10 ELFAKYGVPVPRGIVATTPEEAVEAAEELGGGVWV--V------KAQVhaggrgkaGGVKLAKSPEEAREF 72
SucC COG0045
Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Succinyl-CoA ...
 485-522 3.79e-04

Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Succinyl-CoA synthetase, beta subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 439815 [Multi-domain]  Cd Length: 388  Bit Score: 43.50  E-value: 3.79e-04
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 493474997 485 ESMDLLEAYGIPTPDGEIVDDPDRAREVAASIAGDVVM 522
Cdd:COG0045    7 QAKELLAKYGVPVPRGIVATTPEEAVAAAEELGGPPVV 44
YccU COG1832
Predicted CoA-binding protein [General function prediction only];
7-68 4.87e-04

Predicted CoA-binding protein [General function prediction only];


Pssm-ID: 441437 [Multi-domain]  Cd Length: 138  Bit Score: 40.88  E-value: 4.87e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 493474997   7 LFDPETVAVVGATDREG----AVGRAILENlrdGFagEVVPINPSREAVLGLECYEDATSAP-PIDL 68
Cdd:COG1832   13 LKSAKTIAVVGLSPNPErpsyYVAKYLQRH---GY--RVIPVNPGAKEILGEKVYASLADIPePVDI 74
AccC COG0439
Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway ...
 488-586 2.09e-03

Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440208 [Multi-domain]  Cd Length: 263  Bit Score: 40.63  E-value: 2.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997 488 DLLEAYGIPTPDGEIVDDPDRAREVAASIAGDVVMKivsPDISHKSDigGVKVgVAD-EDVYDAYEDVVARARNYQPDAT 566
Cdd:COG0439   60 EALAAAGVPVPGFALVDSPEEALAFAEEIGYPVVVK---PADGAGSR--GVRV-VRDeEELEAALAEARAEAKAGSPNGE 133

                         90       100
                 ....*....|....*....|.
gi 493474997 567 itgVQIQEMLD-LESSTETIV 586
Cdd:COG0439  134 ---VLVEEFLEgREYSVEGLV 151
PRK14016 PRK14016
cyanophycin synthetase; Provisional
 489-523 3.55e-03

cyanophycin synthetase; Provisional


Pssm-ID: 237586 [Multi-domain]  Cd Length: 727  Bit Score: 40.52  E-value: 3.55e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 493474997 489 LLEAYGIPTPDGEIVDDPDRAREVAASIAGDVVMK 523
Cdd:PRK14016 221 LLAAAGVPVPEGRVVTSAEDAWEAAEEIGYPVVVK 255
LysX COG0189
Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily [Amino acid transport ...
 484-593 4.72e-03

Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily [Amino acid transport and metabolism, Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis, Secondary metabolites biosynthesis, transport and catabolism]; Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 439959 [Multi-domain]  Cd Length: 289  Bit Score: 39.54  E-value: 4.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493474997 484 VESMDLLEAYGIPTPDGEIVDDPDRAREVAASIAGDVVMKivsPDISHksdiGGVKVGVADEDvyDAYEDVVARARNYQP 563
Cdd:COG0189   98 LFTLQLLARAGIPVPPTLVTRDPDDLRAFLEELGGPVVLK---PLDGS----GGRGVFLVEDE--DALESILEALTELGS 168

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 493474997 564 DATItgvqIQEMLDLESST---------ETIVGMNRDPQ 593
Cdd:COG0189  169 EPVL----VQEFIPEEDGRdirvlvvggEPVAAIRRIPA 203
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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