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Conserved domains on  [gi|493177921|ref|WP_006177466|]
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MULTISPECIES: single-stranded DNA-binding protein SSB1 [Enterobacteriaceae]

Protein Classification

single-stranded DNA-binding protein( domain architecture ID 10793128)

single-stranded DNA (ssDNA)-binding protein plays a key role in DNA replication, recombination, and repair

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK09010 PRK09010
single-stranded DNA-binding protein; Provisional
 1-176 3.38e-103

single-stranded DNA-binding protein; Provisional


:

Pssm-ID: 236362 [Multi-domain]  Cd Length: 177  Bit Score: 293.68  E-value: 3.38e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493177921   1 MASRGVNKVILVGNLGQDPEVRYMPSGGAVANITLATSESWRDKATGEMKEQTEWHRVVLFGKLAEVAGEYLRKGSQVYI 80
Cdd:PRK09010   1 MASRGVNKVILVGNLGQDPEVRYMPNGGAVANITLATSESWRDKQTGEMKEQTEWHRVVLFGKLAEVAGEYLRKGSQVYI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493177921  81 EGQLRTRKWTDQSGAEKYTTEVVVNVGGTMQMLGGRQGGGAPAGGGQNQQQGGW-GQPQQPQGGNQFSGGAQSRPQQQSA 159
Cdd:PRK09010  81 EGQLRTRKWTDQSGQDRYTTEVVVNVGGTMQMLGGRQGGGAPAGGNIGGQQQGGwGQPQQPQGGNQFSGGAQSRPQQSAP 160

                        170
                 ....*....|....*..
gi 493177921 160 PAPSNEPPMDFDDDIPF 176
Cdd:PRK09010 161 AAPSNEPPMDFDDDIPF 177
 
Name Accession Description Interval E-value
PRK09010 PRK09010
single-stranded DNA-binding protein; Provisional
 1-176 3.38e-103

single-stranded DNA-binding protein; Provisional


Pssm-ID: 236362 [Multi-domain]  Cd Length: 177  Bit Score: 293.68  E-value: 3.38e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493177921   1 MASRGVNKVILVGNLGQDPEVRYMPSGGAVANITLATSESWRDKATGEMKEQTEWHRVVLFGKLAEVAGEYLRKGSQVYI 80
Cdd:PRK09010   1 MASRGVNKVILVGNLGQDPEVRYMPNGGAVANITLATSESWRDKQTGEMKEQTEWHRVVLFGKLAEVAGEYLRKGSQVYI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493177921  81 EGQLRTRKWTDQSGAEKYTTEVVVNVGGTMQMLGGRQGGGAPAGGGQNQQQGGW-GQPQQPQGGNQFSGGAQSRPQQQSA 159
Cdd:PRK09010  81 EGQLRTRKWTDQSGQDRYTTEVVVNVGGTMQMLGGRQGGGAPAGGNIGGQQQGGwGQPQQPQGGNQFSGGAQSRPQQSAP 160

                        170
                 ....*....|....*..
gi 493177921 160 PAPSNEPPMDFDDDIPF 176
Cdd:PRK09010 161 AAPSNEPPMDFDDDIPF 177
ssb TIGR00621
single stranded DNA-binding protein (ssb); All proteins in this family for which functions are ...
 3-176 3.40e-68

single stranded DNA-binding protein (ssb); All proteins in this family for which functions are known are single-stranded DNA binding proteins that function in many processes including transcription, repair, replication and recombination. Members encoded between genes for ribosomal proteins S6 and S18 should be annotated as primosomal protein N (PriB). Forms in gamma-protoeobacteria are much shorter and poorly recognized by this model. Additional members of this family include phage proteins. Eukaryotic members are organellar proteins. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273179 [Multi-domain]  Cd Length: 164  Bit Score: 204.57  E-value: 3.40e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493177921    3 SRGVNKVILVGNLGQDPEVRYMPSGGAVANITLATSESWRDKAtGEMKEQTEWHRVVLFGKLAEVAGEYLRKGSQVYIEG 82
Cdd:TIGR00621   1 MRMVNKVILVGRLTRDPELRYTPSGNAVANFTLATNRRWKDQD-GEWKEETEWHDIVIFGRLAEVAAQYLKKGSLVYVEG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493177921   83 QLRTRKWTDQSGAEKYTTEVVVNVGGTMQMLGGRQGGGAPAGGGQNQQQGGWGQPQQPQGGnqfsGGAQSRPQQQSAPap 162
Cdd:TIGR00621  80 RLRTRKWEDQNGQKRSKTEIIADNVQLLDLLGARAQGGEFSGGGGSGNRPQGGQEQSATGK----DPAQSAPQSGSAD-- 153

                         170
                  ....*....|....
gi 493177921  163 snePPMDFDDDIPF 176
Cdd:TIGR00621 154 ---PIDGDDDEIPF 164
Ssb COG0629
Single-stranded DNA-binding protein [Replication, recombination and repair];
6-113 6.48e-57

Single-stranded DNA-binding protein [Replication, recombination and repair];


Pssm-ID: 440394  Cd Length: 116  Bit Score: 174.26  E-value: 6.48e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493177921   6 VNKVILVGNLGQDPEVRYMPSGGAVANITLATSESWRDKaTGEMKEQTEWHRVVLFGKLAEVAGEYLRKGSQVYIEGQLR 85
Cdd:COG0629    1 MNKVTLVGRLGKDPELRYTPSGTAVANFRLAVNRRYKDQ-DGEWKDETDWHRVVAWGKLAENAAEYLKKGDKVYVEGRLR 79

                         90       100
                 ....*....|....*....|....*...
gi 493177921  86 TRKWTDQSGAEKYTTEVVVNvggTMQML 113
Cdd:COG0629   80 TRSWEDKDGQKRYTTEVVAD---EIQFL 104
SSB pfam00436
Single-strand binding protein family; This family includes single stranded binding proteins ...
 6-113 9.25e-50

Single-strand binding protein family; This family includes single stranded binding proteins and also the primosomal replication protein N (PriB). PriB forms a complex with PriA, PriC and ssDNA.


Pssm-ID: 425680  Cd Length: 103  Bit Score: 155.86  E-value: 9.25e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493177921    6 VNKVILVGNLGQDPEVRYMPSGGAVANITLATSESWRDKATGEmkEQTEWHRVVLFGKLAEVAGEYLRKGSQVYIEGQLR 85
Cdd:pfam00436   1 MNKVILVGRLTRDPELRYTPNGNAVANFTLATNRRFKDRGEGD--EETDFHRVVVFGKLAEVAAQYLKKGSLVYVEGRLQ 78

                          90       100
                  ....*....|....*....|....*...
gi 493177921   86 TRKWTDQSGAEKYTTEVVVNvggTMQML 113
Cdd:pfam00436  79 TRKYEDQEGQKRYVTEIVAD---EVQFL 103
SSB_OBF cd04496
SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs ...
 9-105 2.63e-44

SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date oligomerize to bring together four OB folds in their active state. The majority (e.g. Escherichia coli SSB) have a single OB fold per monomer, which oligomerize to form a homotetramer. However, Deinococcus and Thermus SSB proteins have two OB folds per monomer, which oligomerize to form a homodimer. Mycobacterium tuberculosis SSB varies in quaternary structure from E. coli SSB. It forms a dimer of dimers having a unique dimer interface, which lends the protein greater stability. Included in this group are OB folds similar to Escherichia coli PriB. E.coli PriB is homodimeric with each monomer having a single OB fold. It does not appear to form higher order oligomers. PriB is an essential protein for the replication restart at forks that have stalled at sites of DNA damage. It also plays a role in the assembly of primosome during replication initiation at the bacteriophage phiX174 origin. PriB physically interacts with SSB and binds ssDNA with high affinity.


Pssm-ID: 239942  Cd Length: 100  Bit Score: 141.98  E-value: 2.63e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493177921   9 VILVGNLGQDPEVRYMPSGGAVANITLATSESWRDKatGEMKEQTEWHRVVLFGKLAEVAGEYLRKGSQVYIEGQLRTRK 88
Cdd:cd04496    1 VILIGRLGKDPELRYTPSGTPVARFSLAVNRRRKDR--DEEEEETDWIRVVAFGKLAENAAKYLKKGDLVYVEGRLRTRS 78

                         90
                 ....*....|....*..
gi 493177921  89 WTDQSGAEKYTTEVVVN 105
Cdd:cd04496   79 WEDKDGQKRYGTEVVAD 95
 
Name Accession Description Interval E-value
PRK09010 PRK09010
single-stranded DNA-binding protein; Provisional
 1-176 3.38e-103

single-stranded DNA-binding protein; Provisional


Pssm-ID: 236362 [Multi-domain]  Cd Length: 177  Bit Score: 293.68  E-value: 3.38e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493177921   1 MASRGVNKVILVGNLGQDPEVRYMPSGGAVANITLATSESWRDKATGEMKEQTEWHRVVLFGKLAEVAGEYLRKGSQVYI 80
Cdd:PRK09010   1 MASRGVNKVILVGNLGQDPEVRYMPNGGAVANITLATSESWRDKQTGEMKEQTEWHRVVLFGKLAEVAGEYLRKGSQVYI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493177921  81 EGQLRTRKWTDQSGAEKYTTEVVVNVGGTMQMLGGRQGGGAPAGGGQNQQQGGW-GQPQQPQGGNQFSGGAQSRPQQQSA 159
Cdd:PRK09010  81 EGQLRTRKWTDQSGQDRYTTEVVVNVGGTMQMLGGRQGGGAPAGGNIGGQQQGGwGQPQQPQGGNQFSGGAQSRPQQSAP 160

                        170
                 ....*....|....*..
gi 493177921 160 PAPSNEPPMDFDDDIPF 176
Cdd:PRK09010 161 AAPSNEPPMDFDDDIPF 177
PRK13732 PRK13732
single-stranded DNA-binding protein; Provisional
 1-176 1.30e-73

single-stranded DNA-binding protein; Provisional


Pssm-ID: 184284 [Multi-domain]  Cd Length: 175  Bit Score: 218.83  E-value: 1.30e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493177921   1 MASRGVNKVILVGNLGQDPEVRYMPSGGAVANITLATSESWRDKATGEMKEQTEWHRVVLFGKLAEVAGEYLRKGSQVYI 80
Cdd:PRK13732   1 MAVRGINKVILVGRLGKDPEVRYIPNGGAVANLQVATSESWRDKQTGEMREQTEWHRVVLFGKLAEVAGEYLRKGAQVYI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493177921  81 EGQLRTRKWTDqSGAEKYTTEVVVNVGGTMQMLGGRQGGGAPAGGGQNQQQGGWGQPQQPQGGNQFSGGAQSRPQQQSAP 160
Cdd:PRK13732  81 EGQLRTRSWED-NGITRYVTEILVKTTGTMQMLGRAPQQNAQPQPGPQQNGQPQSADATKKGGAKTKGRGRKAAQPEPQP 159

                        170
                 ....*....|....*.
gi 493177921 161 APSNEPPMDFDDDIPF 176
Cdd:PRK13732 160 QPPEGEDYGFSDDIPF 175
PRK05733 PRK05733
single-stranded DNA-binding protein; Provisional
 1-176 2.87e-71

single-stranded DNA-binding protein; Provisional


Pssm-ID: 235585 [Multi-domain]  Cd Length: 172  Bit Score: 212.87  E-value: 2.87e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493177921   1 MAsRGVNKVILVGNLGQDPEVRYMPSGGAVANITLATSESWRDKATGEMKEQTEWHRVVLFGKLAEVAGEYLRKGSQVYI 80
Cdd:PRK05733   1 MA-RGVNKVILVGTCGQDPEVRYLPNGNAVTNLSLATSEQWTDKQSGQKVERTEWHRVSLFGKVAEIAGEYLRKGSQVYI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493177921  81 EGQLRTRKWtDQSGAEKYTTEVVVNVGGTMQMLGGRQGGGAPAGGGQNQQQGGWGQPQQPQGGNQFSGGAQSRPQQqsaP 160
Cdd:PRK05733  80 EGKLQTREW-EKDGIKRYTTEIVVDMQGTMQLLGGRPQGDDQGGQGGGNYNQSAPRQQAQRPQQAAQQQSRPAPQQ---P 155

                        170
                 ....*....|....*..
gi 493177921 161 APSNEPPMD-FDDDIPF 176
Cdd:PRK05733 156 APQPAADFDsFDDDIPF 172
ssb TIGR00621
single stranded DNA-binding protein (ssb); All proteins in this family for which functions are ...
 3-176 3.40e-68

single stranded DNA-binding protein (ssb); All proteins in this family for which functions are known are single-stranded DNA binding proteins that function in many processes including transcription, repair, replication and recombination. Members encoded between genes for ribosomal proteins S6 and S18 should be annotated as primosomal protein N (PriB). Forms in gamma-protoeobacteria are much shorter and poorly recognized by this model. Additional members of this family include phage proteins. Eukaryotic members are organellar proteins. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273179 [Multi-domain]  Cd Length: 164  Bit Score: 204.57  E-value: 3.40e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493177921    3 SRGVNKVILVGNLGQDPEVRYMPSGGAVANITLATSESWRDKAtGEMKEQTEWHRVVLFGKLAEVAGEYLRKGSQVYIEG 82
Cdd:TIGR00621   1 MRMVNKVILVGRLTRDPELRYTPSGNAVANFTLATNRRWKDQD-GEWKEETEWHDIVIFGRLAEVAAQYLKKGSLVYVEG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493177921   83 QLRTRKWTDQSGAEKYTTEVVVNVGGTMQMLGGRQGGGAPAGGGQNQQQGGWGQPQQPQGGnqfsGGAQSRPQQQSAPap 162
Cdd:TIGR00621  80 RLRTRKWEDQNGQKRSKTEIIADNVQLLDLLGARAQGGEFSGGGGSGNRPQGGQEQSATGK----DPAQSAPQSGSAD-- 153

                         170
                  ....*....|....
gi 493177921  163 snePPMDFDDDIPF 176
Cdd:TIGR00621 154 ---PIDGDDDEIPF 164
PRK06863 PRK06863
single-stranded DNA-binding protein; Provisional
 5-176 2.03e-66

single-stranded DNA-binding protein; Provisional


Pssm-ID: 136097 [Multi-domain]  Cd Length: 168  Bit Score: 200.19  E-value: 2.03e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493177921   5 GVNKVILVGNLGQDPEVRYMPSGGAVANITLATSESWRDKATGEMKEQTEWHRVVLFGKLAEVAGEYLRKGSQVYIEGQL 84
Cdd:PRK06863   3 GINKVIIVGHLGNDPEIRTMPNGEAVANISVATSESWTDKNTGERREVTEWHRIVFYRRQAEVAGEYLRKGSQVYVEGRL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493177921  85 RTRKWTDQSGAEKYTTEVvvnVGGTMQMLGGRQGGGAPAGGGQNQQQGGWGQPQQpqggnqfSGGAQSRPQQQSAP---A 161
Cdd:PRK06863  83 KTRKWQDQNGQDRYTTEI---QGDVLQMLGGRNQRNAGGYGNSGPAPQQSYQAGQ-------TNNGNSQQASRPAPqqaA 152

                        170
                 ....*....|....*.
gi 493177921 162 PSNEPPMD-FDDDIPF 176
Cdd:PRK06863 153 PQAEPPMDgFDDDIPF 168
PRK06958 PRK06958
single-stranded DNA-binding protein; Provisional
 1-176 3.28e-60

single-stranded DNA-binding protein; Provisional


Pssm-ID: 180777 [Multi-domain]  Cd Length: 182  Bit Score: 185.00  E-value: 3.28e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493177921   1 MASrgVNKVILVGNLGQDPEVRYMPSGGAVANITLATSESWRDKATGEMKEQTEWHRVVLFGKLAEVAGEYLRKGSQVYI 80
Cdd:PRK06958   1 MAS--VNKVILVGNLGADPEVRYLPSGDAVANIRLATTDRYKDKASGEFKEATEWHRVAFFGRLAEIVGEYLKKGSSVYI 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493177921  81 EGQLRTRKWTDQSGAEKYTTEVVVNvggTMQML----------------GGRQGGGAPAGGGQNQQQGGWGQPQQPQGGN 144
Cdd:PRK06958  79 EGRIRTRKWQGQDGQDRYSTEIVAD---QMQMLggrggsgggggggdegGYGGGGGGGGGGYGGESRSGGGGGRASGGGG 155

                        170       180       190
                 ....*....|....*....|....*....|..
gi 493177921 145 QFSGGAQSRPQQqsapAPSNEPPmDFDDDIPF 176
Cdd:PRK06958 156 GGAGGGASRPSA----PAGGGFD-EMDDDIPF 182
Ssb COG0629
Single-stranded DNA-binding protein [Replication, recombination and repair];
6-113 6.48e-57

Single-stranded DNA-binding protein [Replication, recombination and repair];


Pssm-ID: 440394  Cd Length: 116  Bit Score: 174.26  E-value: 6.48e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493177921   6 VNKVILVGNLGQDPEVRYMPSGGAVANITLATSESWRDKaTGEMKEQTEWHRVVLFGKLAEVAGEYLRKGSQVYIEGQLR 85
Cdd:COG0629    1 MNKVTLVGRLGKDPELRYTPSGTAVANFRLAVNRRYKDQ-DGEWKDETDWHRVVAWGKLAENAAEYLKKGDKVYVEGRLR 79

                         90       100
                 ....*....|....*....|....*...
gi 493177921  86 TRKWTDQSGAEKYTTEVVVNvggTMQML 113
Cdd:COG0629   80 TRSWEDKDGQKRYTTEVVAD---EIQFL 104
PRK06341 PRK06341
single-stranded DNA-binding protein; Provisional
 6-176 2.95e-53

single-stranded DNA-binding protein; Provisional


Pssm-ID: 235782 [Multi-domain]  Cd Length: 166  Bit Score: 166.90  E-value: 2.95e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493177921   6 VNKVILVGNLGQDPEVRYMPSGGAVANITLATSESWRDKATGEMKEQTEWHRVVLFGK-LAEVAGEYLRKGSQVYIEGQL 84
Cdd:PRK06341   5 VNKVILIGNLGADPEIRRTQDGRPIANLRIATSETWRDRNSGERKEKTEWHRVVIFNEgLCKVAEQYLKKGAKVYIEGQL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493177921  85 RTRKWTDQSGAEKYTTEVVV-NVGGTMQMLGGRQGGGAPAGGGQNQQQGGWGqpqqpqggnqfSGGAQSRPQQQSAPAPS 163
Cdd:PRK06341  85 QTRKWTDQSGVERYSTEVVLqGFNSTLTMLDGRGEGGGGGGGGDDGGGGDFG-----------SSGPSRGGPRPASSGGG 153

                        170
                 ....*....|...
gi 493177921 164 NEPPMDFDDDIPF 176
Cdd:PRK06341 154 GNFSRDMDDDIPF 166
SSB pfam00436
Single-strand binding protein family; This family includes single stranded binding proteins ...
 6-113 9.25e-50

Single-strand binding protein family; This family includes single stranded binding proteins and also the primosomal replication protein N (PriB). PriB forms a complex with PriA, PriC and ssDNA.


Pssm-ID: 425680  Cd Length: 103  Bit Score: 155.86  E-value: 9.25e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493177921    6 VNKVILVGNLGQDPEVRYMPSGGAVANITLATSESWRDKATGEmkEQTEWHRVVLFGKLAEVAGEYLRKGSQVYIEGQLR 85
Cdd:pfam00436   1 MNKVILVGRLTRDPELRYTPNGNAVANFTLATNRRFKDRGEGD--EETDFHRVVVFGKLAEVAAQYLKKGSLVYVEGRLQ 78

                          90       100
                  ....*....|....*....|....*...
gi 493177921   86 TRKWTDQSGAEKYTTEVVVNvggTMQML 113
Cdd:pfam00436  79 TRKYEDQEGQKRYVTEIVAD---EVQFL 103
PRK08763 PRK08763
single-stranded DNA-binding protein; Provisional
 3-176 6.38e-47

single-stranded DNA-binding protein; Provisional


Pssm-ID: 181549 [Multi-domain]  Cd Length: 164  Bit Score: 150.86  E-value: 6.38e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493177921   3 SRGVNKVILVGNLGQDPEVRYMPSGGAVANITLATSESWRDKaTGEMKEQTEWHRVVLFGKLAEVAGEYLRKGSQVYIEG 82
Cdd:PRK08763   2 ARGINKVILVGNLGNDPDIKYTQSGMTITRISLATTSVRKDR-EGNTQERTEWHRVKFFGKLGEIAGEYLRKGSQCYIEG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493177921  83 QLRTRKWTDQSGAEKYTTEVVVNvggTMQMLggrQGGGAPAGGGQNQQQGGWGQPQQPQGGNQFSGGAQSRPQQQSApap 162
Cdd:PRK08763  81 SIRYDKFTGQDGQERYVTEIVAD---EMQML---GGRGEGGGGGGGGIRPQRQPAPRQNNGQDYAPRRQQPAPQQSA--- 151

                        170
                 ....*....|....*.
gi 493177921 163 snePPMD--FDDDIPF 176
Cdd:PRK08763 152 ---PPMDdfADDDIPF 164
SSB_OBF cd04496
SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs ...
 9-105 2.63e-44

SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date oligomerize to bring together four OB folds in their active state. The majority (e.g. Escherichia coli SSB) have a single OB fold per monomer, which oligomerize to form a homotetramer. However, Deinococcus and Thermus SSB proteins have two OB folds per monomer, which oligomerize to form a homodimer. Mycobacterium tuberculosis SSB varies in quaternary structure from E. coli SSB. It forms a dimer of dimers having a unique dimer interface, which lends the protein greater stability. Included in this group are OB folds similar to Escherichia coli PriB. E.coli PriB is homodimeric with each monomer having a single OB fold. It does not appear to form higher order oligomers. PriB is an essential protein for the replication restart at forks that have stalled at sites of DNA damage. It also plays a role in the assembly of primosome during replication initiation at the bacteriophage phiX174 origin. PriB physically interacts with SSB and binds ssDNA with high affinity.


Pssm-ID: 239942  Cd Length: 100  Bit Score: 141.98  E-value: 2.63e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493177921   9 VILVGNLGQDPEVRYMPSGGAVANITLATSESWRDKatGEMKEQTEWHRVVLFGKLAEVAGEYLRKGSQVYIEGQLRTRK 88
Cdd:cd04496    1 VILIGRLGKDPELRYTPSGTPVARFSLAVNRRRKDR--DEEEEETDWIRVVAFGKLAENAAKYLKKGDLVYVEGRLRTRS 78

                         90
                 ....*....|....*..
gi 493177921  89 WTDQSGAEKYTTEVVVN 105
Cdd:cd04496   79 WEDKDGQKRYGTEVVAD 95
PRK06642 PRK06642
single-stranded DNA-binding protein; Provisional
 6-104 8.85e-44

single-stranded DNA-binding protein; Provisional


Pssm-ID: 135984  Cd Length: 152  Bit Score: 142.55  E-value: 8.85e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493177921   6 VNKVILVGNLGQDPEVRYMPSGGAVANITLATSESWRDKATGEMKEQTEWHRVVLFGK-LAEVAGEYLRKGSQVYIEGQL 84
Cdd:PRK06642   5 LNKVILIGNVGRDPEIRTTGEGKKIINLSLATTETWKDRITSERKERTEWHRVVIFSEgLVSVVERYVTKGSKLYIEGSL 84

                         90       100
                 ....*....|....*....|
gi 493177921  85 RTRKWTDQSGAEKYTTEVVV 104
Cdd:PRK06642  85 QTRKWNDNSGQEKYTTEVVL 104
PRK08486 PRK08486
single-stranded DNA-binding protein; Provisional
 7-176 2.76e-36

single-stranded DNA-binding protein; Provisional


Pssm-ID: 236275 [Multi-domain]  Cd Length: 182  Bit Score: 124.19  E-value: 2.76e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493177921   7 NKVILVGNLGQDPEVRYMPSGGAVANITLATSESWRdKATGEMKEQTEWHRVVLFGKLAEVAGEYLRKGSQVYIEGQLRT 86
Cdd:PRK08486   3 NKVILVGNLTRDVELRYLPSGSAIATIGLATSRRFK-KQDGEKGEEVCFIDIRLFGRTAEIANQYLSKGSKVLIEGRLTF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493177921  87 RKWTDQSGAEKYTTEVVVNvggTMQMLGGRQGGGAPAGGGQNQQQGGWGQPQQPQ----GGNQFSGGAQSRPQQQSAPAP 162
Cdd:PRK08486  82 ESWMDQNGQKRSKHTITAE---SMQMLDSKSDNPQANAMQDNSFHENFNNNYPGNynnpSQDPYMNQAQSYNQNAYAKEN 158

                        170       180
                 ....*....|....*....|....
gi 493177921 163 ---------SNEPPMDFDDD-IPF 176
Cdd:PRK08486 159 qqaqppkyeNSVPEIDIDEEeIPF 182
PRK07459 PRK07459
single-stranded DNA-binding protein; Provisional
 5-105 7.36e-23

single-stranded DNA-binding protein; Provisional


Pssm-ID: 180986  Cd Length: 121  Bit Score: 87.82  E-value: 7.36e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493177921   5 GVNKVILVGNLGQDPEVRYMPSGGAVANITLATSESWRDkatgemkEQTEWHRVVLFGKLAEVAGEYLRKGSQVYIEGQL 84
Cdd:PRK07459   2 SLNSVTLVGRAGRDPEVRYFESGSVVCNLTLAVNRRSRD-------DEPDWFNLEIWGKTAQVAADYVKKGSLIGITGSL 74

                         90       100
                 ....*....|....*....|..
gi 493177921  85 RTRKWTD-QSGAEKYTTEVVVN 105
Cdd:PRK07459  75 KFDRWTDrNTGEDRSKPVIRVD 96
PRK07275 PRK07275
single-stranded DNA-binding protein; Provisional
 6-176 4.08e-18

single-stranded DNA-binding protein; Provisional


Pssm-ID: 180915 [Multi-domain]  Cd Length: 162  Bit Score: 76.85  E-value: 4.08e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493177921   6 VNKVILVGNLGQDPEVRYMPSGGAVANITLATSESWRDkATGEmkEQTEWHRVVLFGKLAEVAGEYLRKGSQVYIEGQLR 85
Cdd:PRK07275   2 INNVVLVGRMTRDAELRYTPSNVAVATFTLAVNRTFKS-QNGE--READFINCVIWRQQAENLANWAKKGALIGVTGRIQ 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493177921  86 TRKWTDQSGAEKYTTEVVVNvggTMQMLGGRQGGGAPAGGGQNQQQGGWGqpqqpqggnqfSGGAQSRPQQQSAPAPSNE 165
Cdd:PRK07275  79 TRNYENQQGQRVYVTEVVAD---NFQMLESRATREGGSGGSYNGGFNNAP-----------SANSYSAPAQQTPNFGRDE 144

                        170
                 ....*....|....*...
gi 493177921 166 P------PMDF-DDDIPF 176
Cdd:PRK07275 145 SpfgnsnPMDIsDDDLPF 162
PRK07274 PRK07274
single-stranded DNA-binding protein; Provisional
 7-104 1.11e-16

single-stranded DNA-binding protein; Provisional


Pssm-ID: 180914  Cd Length: 131  Bit Score: 72.10  E-value: 1.11e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493177921   7 NKVILVGNLGQDPEVRYMPSGGAVANITLATSESWRDkATGEmkEQTEWHRVVLFGKLAEVAGEYLRKGSQVYIEGQLRT 86
Cdd:PRK07274   3 NKVILIGRLTATPELVKTANDKSVARVTLAVNRRFKN-QNGE--READFINVVLWGKLAETLASYASKGSLISIDGELRT 79

                         90
                 ....*....|....*...
gi 493177921  87 RKWtDQSGAEKYTTEVVV 104
Cdd:PRK07274  80 RKY-EKDGQTHYVTEVLC 96
PRK06752 PRK06752
single-stranded DNA-binding protein; Validated
 6-104 1.41e-16

single-stranded DNA-binding protein; Validated


Pssm-ID: 168660  Cd Length: 112  Bit Score: 71.60  E-value: 1.41e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493177921   6 VNKVILVGNLGQDPEVRYMPSGGAVANITLATSESWRDkATGEmkEQTEWHRVVLFGKLAEVAGEYLRKGSQVYIEGQLR 85
Cdd:PRK06752   2 MNRVVLIGRLTKEPELYYTKQGVAYARVCVAVNRGFRN-SLGE--QQVDFINCVVWRKSAENVTEYCTKGSLVGITGRIH 78

                         90
                 ....*....|....*....
gi 493177921  86 TRKWTDQSGAEKYTTEVVV 104
Cdd:PRK06752  79 TRNYEDDQGKRIYITEVVI 97
PRK06751 PRK06751
single-stranded DNA-binding protein; Provisional
 6-103 3.04e-16

single-stranded DNA-binding protein; Provisional


Pssm-ID: 168659 [Multi-domain]  Cd Length: 173  Bit Score: 72.14  E-value: 3.04e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493177921   6 VNKVILVGNLGQDPEVRYMPSGGAVANITLATSESWRDKatgEMKEQTEWHRVVLFGKLAEVAGEYLRKGSQVYIEGQLR 85
Cdd:PRK06751   2 MNRVILVGRLTKDPDLRYTPNGVAVATFTLAVNRAFANQ---QGEREADFINCVIWRKQAENVANYLKKGSLAGVDGRLQ 78

                         90
                 ....*....|....*...
gi 493177921  86 TRKWTDQSGAEKYTTEVV 103
Cdd:PRK06751  79 TRNYEGQDGKRVYVTEVL 96
PRK07772 PRK07772
single-stranded DNA-binding protein; Provisional
 11-104 1.92e-12

single-stranded DNA-binding protein; Provisional


Pssm-ID: 236092 [Multi-domain]  Cd Length: 186  Bit Score: 62.36  E-value: 1.92e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493177921  11 LVGNLGQDPEVRYMPSGGAVANITLATSESWRDKATGEMKE-QTEWHRVVLFGKLAEVAGEYLRKGSQVYIEGQLRTRKW 89
Cdd:PRK07772   9 VVGNLTADPELRFTPSGAAVANFTVASTPRTFDRQTNEWKDgEALFLRCSIWRQAAENVAESLTKGMRVIVTGRLKQRSY 88

                         90
                 ....*....|....*
gi 493177921  90 TDQSGAEKYTTEVVV 104
Cdd:PRK07772  89 ETREGEKRTVVELEV 103
PRK06293 PRK06293
single-stranded DNA-binding protein; Provisional
 9-105 1.30e-10

single-stranded DNA-binding protein; Provisional


Pssm-ID: 180517 [Multi-domain]  Cd Length: 161  Bit Score: 56.83  E-value: 1.30e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493177921   9 VILVGNLGQDPEVRYMPSGGAVANITLATseswrdKATGEMKEQTEWHRVVLFGKLAEVAGEYLRKGSQVYIEGQLRTRK 88
Cdd:PRK06293   4 GYIVGRLGADPEERMTSKGKRVVVLRLGV------KSRVGSKDETVWCRCNIWGNRYDKMLPYLKKGSGVIVAGEMSPES 77

                         90
                 ....*....|....*..
gi 493177921  89 WTDQSGAEKYTTEVVVN 105
Cdd:PRK06293  78 YVDKDGSPQSSLVVSVD 94
PRK08182 PRK08182
single-stranded DNA-binding protein; Provisional
 13-103 4.86e-04

single-stranded DNA-binding protein; Provisional


Pssm-ID: 169261  Cd Length: 148  Bit Score: 38.51  E-value: 4.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493177921  13 GNLGQDPEVRYMPSGG----AVANITLATSESWRDKAtGEMKEQTE-WHRVVLFGKLAEVAGEYLRKGSQVYIEGQLRTR 87
Cdd:PRK08182   9 GNIGSAPEYREFPNGNdeprRLLRLNVYFDNPVPTKD-GEYEDRGGfWAPVELWHRDAEHWARLYQKGMRVLVEGRMERD 87

                         90
                 ....*....|....*.
gi 493177921  88 KWTDQSGAEKYTTEVV 103
Cdd:PRK08182  88 EWTDNEDNERVTFKVE 103
PHA01740 PHA01740
putative single-stranded DNA-binding protein
 164-176 4.21e-03

putative single-stranded DNA-binding protein


Pssm-ID: 133956  Cd Length: 158  Bit Score: 36.28  E-value: 4.21e-03
                         10
                 ....*....|...
gi 493177921 164 NEPPMDFDDDIPF 176
Cdd:PHA01740 146 NEPPMDFDDDIPF 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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