|
Name |
Accession |
Description |
Interval |
E-value |
| pgi |
PRK00179 |
glucose-6-phosphate isomerase; Reviewed |
4-548 |
0e+00 |
|
glucose-6-phosphate isomerase; Reviewed
Pssm-ID: 234679 Cd Length: 548 Bit Score: 1009.32 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 4 DATKLEAtVAKLKKHWAESAPRDMRAAFSADPGRFGRYSLCLDDLLFDWSKCRVNDETMALLKELAVAADVEGRRAAMFA 83
Cdd:PRK00179 4 NLTQTPA-WQALQAHADEIKDVHLRDLFAADPDRFERFSLTAGGLLLDYSKNRITDETLALLLDLAREAGLEGARDAMFA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 84 GEHINNTEDRAVLHVALRDTSSKEVLVDGHNVLPDVKHVLDRMAAFADGIRSGALKGASGRKITDIVNIGIGGSDLGPVM 163
Cdd:PRK00179 83 GEKINTTEDRAVLHTALRNPSNTPILVDGQDVMPEVHAVLARMKAFAEAVRSGEWKGYTGKAITDVVNIGIGGSDLGPVM 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 164 ATLALAPYHDEP-RAHFVSNIDGAHIADTLSPLDPASTLIIVASKTFTTIETMTNAQTARKWVADTLG-EAAVGAHFAAV 241
Cdd:PRK00179 163 VTEALRPYADPGlRVHFVSNVDGAHLAETLKKLDPETTLFIVASKTFTTQETLTNAHSARDWFLAAGGdEAAVAKHFVAV 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 242 STALDKVAAFGIPEDRVFGFWDWVGGRYSVWSAIGLPVMIAVGPDNFRKFLAGAHAMDVHFRDAPLEKNLPVMLGLIGYW 321
Cdd:PRK00179 243 STNAEAVAEFGIDPDNMFGFWDWVGGRYSLWSAIGLSIALAIGPDNFEELLAGAHAMDEHFRTAPLEKNLPVLLALIGVW 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 322 HRAICGYGSRAIIPYDQRLSRLPAYLQQLDMESNGKSVTLDGKPVSGPTGPVVWGEPGTNGQHAFFQLLHQGTDTIPLEF 401
Cdd:PRK00179 323 YRNFFGAQSHAVLPYDQYLHRFPAYLQQLEMESNGKSVDRDGTPVDYQTGPIIWGEPGTNGQHAFFQLLHQGTKLVPADF 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 402 IVAAKGHEPtLDHQHEMLMANCLAQSEALMKGRTLDEARAQLQAKNLPASQVERIAPHRVFSGNRPSLTLIHDMLDPYTL 481
Cdd:PRK00179 403 IAPAQPHNP-LGDHHDLLLANCFAQTEALMFGKTAEEVRAELRAKGLDEAEAEELAPHKVFPGNRPSTTILLDRLTPFTL 481
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 493111874 482 GRLIALYEHRVFVEAQIFGINAFDQWGVELGKELATELLPVVSGKEGASGRDASTQGLVAHLHARRK 548
Cdd:PRK00179 482 GALIALYEHKVFVQGVIWGINSFDQWGVELGKQLAKRILPELEGDSEASAHDSSTNGLINRYRAWRG 548
|
|
| Pgi |
COG0166 |
Glucose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Glucose-6-phosphate ... |
37-545 |
0e+00 |
|
Glucose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Glucose-6-phosphate isomerase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439936 Cd Length: 484 Bit Score: 731.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 37 RFGRYSLCLDDLLFDWSKCRVNDETMALLKELAVAADvegRRAAMFAGEHINNTEDRAVLHVALRDtsskevLVDGHNVL 116
Cdd:COG0166 12 RFERFSLEAAGLLLDYSKNRITDETLELLLELAEEEE---AREALFAGEKINPTEGRAVLHGALRL------PEAGEDVM 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 117 PDVKHVLDRMAAFADGIRSGalkgasgRKITDIVNIGIGGSDLGPVMATLALAPY-HDEPRAHFVSNIDGAHIADTLSPL 195
Cdd:COG0166 83 PEVREELARIKAFAEKVRTG-------KRITDVVNIGIGGSDLGPRAVIEALKPYfRDGPRVHFVSNVDPDYLAELLAGL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 196 DPASTLIIVASKTFTTIETMTNAQTARKWVADTLGEAaVGAHFAAVSTALDKVAAFGIPED-RVFGFWDWVGGRYSVWSA 274
Cdd:COG0166 156 DPETTLFIVISKSGTTQETLTNARVAREWLEKAGGED-AAKHFVAVTDNAGALRAFGIDEGyNTFPFPDWVGGRYSVLSA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 275 IGLPVMIAVGPDnFRKFLAGAHAMDVHFRDAPLEKNLPVMLGLIGYWHRAICGYGSRAIIPYDQRLSRLPAYLQQLDMES 354
Cdd:COG0166 235 VGLLPAAAIGID-FEELLAGAHAMDEHFRTAPLEENPPVLLALLGIWYRNFKGAETEAVLPYDQRLERFPAWLQQLWMES 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 355 NGKSVTLDGKPVSGPTGPVvwGEPGTNGQHAFFQLLHQGTDTIPLEFIVAAKGHEPTldhqHEMLMANClaQSEALMKGR 434
Cdd:COG0166 314 NGKSVDRDGNPVGYGTGPV--GEPGTTDQHSFGQLLHQGTRDIPVTFIAVAEPHHDI----PDLLLANL--QGLALLAGK 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 435 TLDEARAQLQAKnlpasqveriAPHRVFSGNRPSLTLIHDMLDPYTLGRLIALYEHRVFVEAQIFGINAFDQWGVELGKE 514
Cdd:COG0166 386 TLDEVLALAAEA----------TPHALFPGNRPSNTILLPKLTPYTLGALIALYEHAVFVQGVLWGINPFDQPGVELGKK 455
|
490 500 510
....*....|....*....|....*....|.
gi 493111874 515 LATELLPVVSGKEGASGrdASTQGLVAHLHA 545
Cdd:COG0166 456 LAFALLGKLGGEEAAAG--DSTEALLKRLRA 484
|
|
| PGI |
pfam00342 |
Phosphoglucose isomerase; Phosphoglucose isomerase catalyzes the interconversion of ... |
51-540 |
0e+00 |
|
Phosphoglucose isomerase; Phosphoglucose isomerase catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate.
Pssm-ID: 395271 Cd Length: 487 Bit Score: 693.06 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 51 DWSKCRVNDETMALLKELAVAADVEGRRAAMFAGEHINNTEDRAVLHVALRDTSSKEVLVDGHNVLPDVKHVLDRMAAFA 130
Cdd:pfam00342 1 DYSKNHINDEILTALVKLAEERGVDAAREAMFNGEKINSTENRAVLHVALRNRSNTPIYVDGKDVMPEVNAVLAKMKSFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 131 DGIRSGALKGASGRKITDIVNIGIGGSDLGPVMATLALAPYHD-EPRAHFVSNIDGAHIADTLSPLDPASTLIIVASKTF 209
Cdd:pfam00342 81 ERVRSGEWKGYTGKAITDVVNIGIGGSDLGPVMVTEALKPYSGrDLDVHFVSNVDGTHIAEVLKKLNPETTLFIVASKTF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 210 TTIETMTNAQTARKWVADTLGE-AAVGAHFAAVSTALDKVAAFGIPEDRVFGFWDWVGGRYSVWSAIGLPVMIAVGPDNF 288
Cdd:pfam00342 161 TTAETMTNAESAKEWLLKALKDdSAVAKHFIALSTNAEKVEEFGIDTKNMFEFWDWVGGRYSLWSAIGLPIALSIGFENF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 289 RKFLAGAHAMDVHFRDAPLEKNLPVMLGLIGYWHRAICGYGSRAIIPYDQRLSRLPAYLQQLDMESNGKSVTLDGKPVSG 368
Cdd:pfam00342 241 QQLLEGAHAMDKHFLSAPPEKNIPVLLALLGVWYNNFFGAQTHAILPYDQYLHRFPAYLQQLDMESNGKYVTRDGVLVDH 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 369 PTGPVVWGEPGTNGQHAFFQLLHQGTDTIPLEFIVAAKGHEPTLDHQHEMLMANCLAQSEALMKGRTLDEARAQLQaknl 448
Cdd:pfam00342 321 QTGPIIFGEPGTNGQHAFYQLIHQGTRLIPCDFIGAVQSQNPENGDHHKILLSNFFAQTEALMVGKSPEEVRKELA---- 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 449 pASQVERIAPHRVFSGNRPSLTLIHDMLDPYTLGRLIALYEHRVFVEAQIFGINAFDQWGVELGKELATELLPVVSGKEG 528
Cdd:pfam00342 397 -AADVEHLIPHKTFTGNRPSNSILVQKLTPATLGALIAMYEHKIFVQGAIWGINSFDQWGVELGKVLAKSILPELENSNK 475
|
490
....*....|..
gi 493111874 529 ASGRDASTQGLV 540
Cdd:pfam00342 476 VSSHDSSTNGLI 487
|
|
| SIS_PGI_2 |
cd05016 |
Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification ... |
330-519 |
7.59e-79 |
|
Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of glucose 6-phosphate to fructose 6-phosphate. As an extracellular protein, PGI also has functions equivalent to neuroleukin (NLK), autocrine motility factor (AMF), and maturation factor (MF). Evidence suggests that PGI, NLK, AMF, and MF are closely related or identical. NLK is a neurotrophic growth factor that promotes regeneration and survival of neurons. The dimeric form of NLK has isomerase function, whereas its monomeric form carries out neurotrophic activity. AMF is a cytokine that stimulates cell migration and metastasis. MF mediates the differentiation of human myeloid leukemic HL-60 cells to terminal monocytic cells.
Pssm-ID: 240147 Cd Length: 164 Bit Score: 244.82 E-value: 7.59e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 330 SRAIIPYDQRLSRLPAYLQQLDMESNGKSVTLDGKPVsgPTGPVVWGEPGTNGQHAFFQLLHQGTDTIPLEFIVAAKGHE 409
Cdd:cd05016 2 THALLPYSQRLERFPAWLQQLDMESNGKSVTRDGEDY--PTGPIPWGAPGTNDQHSFFQLIHQGTKDKPVDFIAVKKPQN 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 410 PTLD-----HQHEMLMANCLAQSEALMkgrtldearaqlqaknlpasqveriaphrvFSGNRPSLTLIHDMLDPYTLGRL 484
Cdd:cd05016 80 DVLDylagkTLHDLLLANCLATREALM------------------------------FPGGRPSNTIVLPELTPYTLGAL 129
|
170 180 190
....*....|....*....|....*....|....*
gi 493111874 485 IALYEHRVFVEAQIFGINAFDQWGVELGKELATEL 519
Cdd:cd05016 130 LALYEHKTAVQGALLGINPFDQPGVELGKKLAKKI 164
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| pgi |
PRK00179 |
glucose-6-phosphate isomerase; Reviewed |
4-548 |
0e+00 |
|
glucose-6-phosphate isomerase; Reviewed
Pssm-ID: 234679 Cd Length: 548 Bit Score: 1009.32 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 4 DATKLEAtVAKLKKHWAESAPRDMRAAFSADPGRFGRYSLCLDDLLFDWSKCRVNDETMALLKELAVAADVEGRRAAMFA 83
Cdd:PRK00179 4 NLTQTPA-WQALQAHADEIKDVHLRDLFAADPDRFERFSLTAGGLLLDYSKNRITDETLALLLDLAREAGLEGARDAMFA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 84 GEHINNTEDRAVLHVALRDTSSKEVLVDGHNVLPDVKHVLDRMAAFADGIRSGALKGASGRKITDIVNIGIGGSDLGPVM 163
Cdd:PRK00179 83 GEKINTTEDRAVLHTALRNPSNTPILVDGQDVMPEVHAVLARMKAFAEAVRSGEWKGYTGKAITDVVNIGIGGSDLGPVM 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 164 ATLALAPYHDEP-RAHFVSNIDGAHIADTLSPLDPASTLIIVASKTFTTIETMTNAQTARKWVADTLG-EAAVGAHFAAV 241
Cdd:PRK00179 163 VTEALRPYADPGlRVHFVSNVDGAHLAETLKKLDPETTLFIVASKTFTTQETLTNAHSARDWFLAAGGdEAAVAKHFVAV 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 242 STALDKVAAFGIPEDRVFGFWDWVGGRYSVWSAIGLPVMIAVGPDNFRKFLAGAHAMDVHFRDAPLEKNLPVMLGLIGYW 321
Cdd:PRK00179 243 STNAEAVAEFGIDPDNMFGFWDWVGGRYSLWSAIGLSIALAIGPDNFEELLAGAHAMDEHFRTAPLEKNLPVLLALIGVW 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 322 HRAICGYGSRAIIPYDQRLSRLPAYLQQLDMESNGKSVTLDGKPVSGPTGPVVWGEPGTNGQHAFFQLLHQGTDTIPLEF 401
Cdd:PRK00179 323 YRNFFGAQSHAVLPYDQYLHRFPAYLQQLEMESNGKSVDRDGTPVDYQTGPIIWGEPGTNGQHAFFQLLHQGTKLVPADF 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 402 IVAAKGHEPtLDHQHEMLMANCLAQSEALMKGRTLDEARAQLQAKNLPASQVERIAPHRVFSGNRPSLTLIHDMLDPYTL 481
Cdd:PRK00179 403 IAPAQPHNP-LGDHHDLLLANCFAQTEALMFGKTAEEVRAELRAKGLDEAEAEELAPHKVFPGNRPSTTILLDRLTPFTL 481
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 493111874 482 GRLIALYEHRVFVEAQIFGINAFDQWGVELGKELATELLPVVSGKEGASGRDASTQGLVAHLHARRK 548
Cdd:PRK00179 482 GALIALYEHKVFVQGVIWGINSFDQWGVELGKQLAKRILPELEGDSEASAHDSSTNGLINRYRAWRG 548
|
|
| Pgi |
COG0166 |
Glucose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Glucose-6-phosphate ... |
37-545 |
0e+00 |
|
Glucose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Glucose-6-phosphate isomerase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439936 Cd Length: 484 Bit Score: 731.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 37 RFGRYSLCLDDLLFDWSKCRVNDETMALLKELAVAADvegRRAAMFAGEHINNTEDRAVLHVALRDtsskevLVDGHNVL 116
Cdd:COG0166 12 RFERFSLEAAGLLLDYSKNRITDETLELLLELAEEEE---AREALFAGEKINPTEGRAVLHGALRL------PEAGEDVM 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 117 PDVKHVLDRMAAFADGIRSGalkgasgRKITDIVNIGIGGSDLGPVMATLALAPY-HDEPRAHFVSNIDGAHIADTLSPL 195
Cdd:COG0166 83 PEVREELARIKAFAEKVRTG-------KRITDVVNIGIGGSDLGPRAVIEALKPYfRDGPRVHFVSNVDPDYLAELLAGL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 196 DPASTLIIVASKTFTTIETMTNAQTARKWVADTLGEAaVGAHFAAVSTALDKVAAFGIPED-RVFGFWDWVGGRYSVWSA 274
Cdd:COG0166 156 DPETTLFIVISKSGTTQETLTNARVAREWLEKAGGED-AAKHFVAVTDNAGALRAFGIDEGyNTFPFPDWVGGRYSVLSA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 275 IGLPVMIAVGPDnFRKFLAGAHAMDVHFRDAPLEKNLPVMLGLIGYWHRAICGYGSRAIIPYDQRLSRLPAYLQQLDMES 354
Cdd:COG0166 235 VGLLPAAAIGID-FEELLAGAHAMDEHFRTAPLEENPPVLLALLGIWYRNFKGAETEAVLPYDQRLERFPAWLQQLWMES 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 355 NGKSVTLDGKPVSGPTGPVvwGEPGTNGQHAFFQLLHQGTDTIPLEFIVAAKGHEPTldhqHEMLMANClaQSEALMKGR 434
Cdd:COG0166 314 NGKSVDRDGNPVGYGTGPV--GEPGTTDQHSFGQLLHQGTRDIPVTFIAVAEPHHDI----PDLLLANL--QGLALLAGK 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 435 TLDEARAQLQAKnlpasqveriAPHRVFSGNRPSLTLIHDMLDPYTLGRLIALYEHRVFVEAQIFGINAFDQWGVELGKE 514
Cdd:COG0166 386 TLDEVLALAAEA----------TPHALFPGNRPSNTILLPKLTPYTLGALIALYEHAVFVQGVLWGINPFDQPGVELGKK 455
|
490 500 510
....*....|....*....|....*....|.
gi 493111874 515 LATELLPVVSGKEGASGrdASTQGLVAHLHA 545
Cdd:COG0166 456 LAFALLGKLGGEEAAAG--DSTEALLKRLRA 484
|
|
| PGI |
pfam00342 |
Phosphoglucose isomerase; Phosphoglucose isomerase catalyzes the interconversion of ... |
51-540 |
0e+00 |
|
Phosphoglucose isomerase; Phosphoglucose isomerase catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate.
Pssm-ID: 395271 Cd Length: 487 Bit Score: 693.06 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 51 DWSKCRVNDETMALLKELAVAADVEGRRAAMFAGEHINNTEDRAVLHVALRDTSSKEVLVDGHNVLPDVKHVLDRMAAFA 130
Cdd:pfam00342 1 DYSKNHINDEILTALVKLAEERGVDAAREAMFNGEKINSTENRAVLHVALRNRSNTPIYVDGKDVMPEVNAVLAKMKSFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 131 DGIRSGALKGASGRKITDIVNIGIGGSDLGPVMATLALAPYHD-EPRAHFVSNIDGAHIADTLSPLDPASTLIIVASKTF 209
Cdd:pfam00342 81 ERVRSGEWKGYTGKAITDVVNIGIGGSDLGPVMVTEALKPYSGrDLDVHFVSNVDGTHIAEVLKKLNPETTLFIVASKTF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 210 TTIETMTNAQTARKWVADTLGE-AAVGAHFAAVSTALDKVAAFGIPEDRVFGFWDWVGGRYSVWSAIGLPVMIAVGPDNF 288
Cdd:pfam00342 161 TTAETMTNAESAKEWLLKALKDdSAVAKHFIALSTNAEKVEEFGIDTKNMFEFWDWVGGRYSLWSAIGLPIALSIGFENF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 289 RKFLAGAHAMDVHFRDAPLEKNLPVMLGLIGYWHRAICGYGSRAIIPYDQRLSRLPAYLQQLDMESNGKSVTLDGKPVSG 368
Cdd:pfam00342 241 QQLLEGAHAMDKHFLSAPPEKNIPVLLALLGVWYNNFFGAQTHAILPYDQYLHRFPAYLQQLDMESNGKYVTRDGVLVDH 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 369 PTGPVVWGEPGTNGQHAFFQLLHQGTDTIPLEFIVAAKGHEPTLDHQHEMLMANCLAQSEALMKGRTLDEARAQLQaknl 448
Cdd:pfam00342 321 QTGPIIFGEPGTNGQHAFYQLIHQGTRLIPCDFIGAVQSQNPENGDHHKILLSNFFAQTEALMVGKSPEEVRKELA---- 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 449 pASQVERIAPHRVFSGNRPSLTLIHDMLDPYTLGRLIALYEHRVFVEAQIFGINAFDQWGVELGKELATELLPVVSGKEG 528
Cdd:pfam00342 397 -AADVEHLIPHKTFTGNRPSNSILVQKLTPATLGALIAMYEHKIFVQGAIWGINSFDQWGVELGKVLAKSILPELENSNK 475
|
490
....*....|..
gi 493111874 529 ASGRDASTQGLV 540
Cdd:pfam00342 476 VSSHDSSTNGLI 487
|
|
| PLN02649 |
PLN02649 |
glucose-6-phosphate isomerase |
14-549 |
0e+00 |
|
glucose-6-phosphate isomerase
Pssm-ID: 215351 [Multi-domain] Cd Length: 560 Bit Score: 632.46 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 14 KLKKHWAESAPRDMRAAFsADPGRFGRYSLCLDDLLFDWSKCRVNDETMALLKELAVAADVEGRRAAMFAGEHINNTEDR 93
Cdd:PLN02649 16 RLVAHVYQIKKTHLRELL-NDAERCQSMIAEFDGIYLDYSRQRVTDETMELLFPLAEAANLFEKIEAMFSGEIINSTEDR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 94 AVLHVALRDTSSKEVLVDGHNVLPDVKHVLDRMAAFADGIRSGALKGASGRKITDIVNIGIGGSDLGPVMATLALAPYHD 173
Cdd:PLN02649 95 AVLHVALRAPRLAPILVDGKNVVPEVWEVLDKIKAFSEDVRSGKWKGATGKRFTNVVSIGIGGSFLGPLFVHEALATDPE 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 174 EPRA------HFVSNIDGAHIADTLSPLDPASTLIIVASKTFTTIETMTNAQTARKWVADTLGEAAVGAHFAAVSTALDK 247
Cdd:PLN02649 175 ALKSakgrklRFLANVDPVDIARQIAQLDPETTLVVVVSKTFTTAETMLNARTVRKWLRDALGGLAVAKHMVAVSTNLLL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 248 VAAFGIPEDRVFGFWDWVGGRYSVWSAIG-LPVMIAVGPDNFRKFLAGAHAMDVHFRDAPLEKNLPVMLGLIGYWHRAIC 326
Cdd:PLN02649 255 VNKFGIDPWNAFPFWDWVGGRYSVCSAVGlLPLSLQYGFDVVEEFLEGAASMDEHFRTAPLKENIPVLLGLLSVWNSSFL 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 327 GYGSRAIIPYDQRLSRLPAYLQQLDMESNGKSVTLDGKPVSGPTGPVVWGEPGTNGQHAFFQLLHQGTdTIPLEFIVAAK 406
Cdd:PLN02649 335 GYPARAILPYSQALLKFAPHIQQLDMESNGKGVDLDGNPLPVNTGEIDFGEPGTNGQHSFYQLIHQGR-NIPCDFIGVVR 413
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 407 GHEPTLDHQ------HEMLMANCLAQSEALMKGRTLDearaQLQAKNLPASQVeriaPHRVFSGNRPSLTLIHDMLDPYT 480
Cdd:PLN02649 414 SQQPVHLWLgegvsnHDELMSNFFAQPDALAYGKTPE----QLRAEGVPEELI----PHKVFAGNRPSLSILLPELTAYT 485
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 493111874 481 LGRLIALYEHRVFVEAQIFGINAFDQWGVELGKELATELLPVVSGK----EGASGRDASTQGLVAHLHARRKA 549
Cdd:PLN02649 486 VGQLLALYEHRVAVQGFIWNINSFDQWGVELGKALAKRVRAVLNEArtkgEPVEGFNSSTTALLNHYLANKRA 558
|
|
| PTZ00430 |
PTZ00430 |
glucose-6-phosphate isomerase; Provisional |
45-545 |
0e+00 |
|
glucose-6-phosphate isomerase; Provisional
Pssm-ID: 185612 Cd Length: 552 Bit Score: 582.36 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 45 LDDLLFDWSKCRVNDETMALLKELAVAADVEGRRAAMFAGEHINNTEDRAVLHVALRDTSSKEVLVDGHNVLPDVKHVLD 124
Cdd:PTZ00430 41 FKGVTLDLSRQRLDEETLKLLIELAEEAKLKEKIKDMFNGEKINTTENRAVLHTALRAPRGEKVVVDGKNVLEDVHEVLD 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 125 RMAAFADGIRSGALKGASGRKITDIVNIGIGGSDLGPVMATLALAPYHDEPRA------HFVSNIDGAHIADTLSPLDPA 198
Cdd:PTZ00430 121 RIKKFSDKIRSGEILGSTGKKLKNVICIGIGGSYLGTEFVYEALRTYGEAREAskgrklRFLANVDPIDVRRATEGLDPE 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 199 STLIIVASKTFTTIETMTNAQTARKWVADTLG-EAAVGAHFAAVSTALDKVAAFGIPEDRVFGFWDWVGGRYSVWSAIG- 276
Cdd:PTZ00430 201 ETLVVIISKTFTTAETMLNAKTVRQWLLDNIKsKEALSKHLCAVSTNLKLTSEFGIPDENVFGFWDWVGGRFSVTSAVGi 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 277 LPVMIAVGPDNFRKFLAGAHAMDVHFRDAPLEKNLPVMLGLIGYWHRAICGYGSRAIIPYDQRLSRLPAYLQQLDMESNG 356
Cdd:PTZ00430 281 LPLSIQFGYDIVQQFLNGCHDMDEHFRTAPLEENLPVLLGLTSFYNSTFLGYNCVAILPYCQALLKFPAHVQQLLMESNG 360
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 357 KSVTLDGKPVSGPTGPVVWGEPGTNGQHAFFQLLHQGTdTIPLEFIVAAKGHEPT-LDH----QHEMLMANCLAQSEALM 431
Cdd:PTZ00430 361 KSVTLDGNTLDYNTGEIYFGEPGTNGQHSFYQLLHQGR-VVPSEFIGFAKSQNPIkLLGepvsNHDELMSNFFAQPDALA 439
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 432 KGRTLDearaQLQAKNLPasqvERIAPHRVFSGNRPSLTLIHDMLDPYTLGRLIALYEHRVFVEAQIFGINAFDQWGVEL 511
Cdd:PTZ00430 440 FGKTYE----ELEKEGVP----EELIPHKVFPGNRPSLLLLFPELNPYTIGQLLALYEHRTVVEGFLWNINSFDQWGVEL 511
|
490 500 510 520
....*....|....*....|....*....|....*....|.
gi 493111874 512 GKELATELLPVVSGKEGASGRDA-------STQGLVAHLHA 545
Cdd:PTZ00430 512 GKVLAKDVRNLFKDNRSNSSPHAkeskfngSTKRLLSYYLQ 552
|
|
| pgi |
PRK14095 |
glucose-6-phosphate isomerase; Provisional |
3-543 |
4.18e-144 |
|
glucose-6-phosphate isomerase; Provisional
Pssm-ID: 237608 Cd Length: 533 Bit Score: 425.97 E-value: 4.18e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 3 RDATKLEATvAKLKKHWAESAPRDMRAAFSADpgRFGRYSLCLDDLLFDWSKCRVNDETMALLKELAVAADVEGRRAAMF 82
Cdd:PRK14095 5 KNFLDLESF-KILQELAPEPLDLTLPGVLSEE--RIKKYSLSGEGFTYNYATERVDDRILAALQNLADEAELIEKMKAMQ 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 83 AGEHINN-----TEDRAVLHVALRDTSSKEVLVD-GHNVLPDVKHVLDRMAAFADGIRSGALKGASGRKITDIVNIGIGG 156
Cdd:PRK14095 82 NGAVINRiegfpSENRPVLHTATRGQVGDSVLTDeAEDMAEFSKRELERLAEFLKKVRSGEIKNSNGKKFTTVVQIGIGG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 157 SDLGPVMATLALAPY-HDEPRAHFVSNIDGAHIADTLSPLDPASTLIIVASKTFTTIETMTNAQtarkWVADTLGEAAVG 235
Cdd:PRK14095 162 SDLGPKALYLALKNYaKKDKRVHFISNVDPDDAAEVLSEIDLAKTLFIVVSKSGTTLETAANEE----FVRDALKKAGLD 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 236 A--HFAAVS---TALDKvaafgiPED--RVFGFWDWVGGRYSVWSAIGLPVM-IAVGPDNFRKFLAGAHAMDVHFRDAPL 307
Cdd:PRK14095 238 YkkHFIAVTsegSPMDD------ESGylEVFHMWDSIGGRFSSTSMVGGVVLgFAFGFEVFKEFLKGAAAMDKAALNPNI 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 308 EKNLPVMLGLIGYWHRAICGYGSRAIIPYDQRLSRLPAYLQQLDMESNGKSVTLDGKPVSGPTGPVVWGEPGTNGQHAFF 387
Cdd:PRK14095 312 RENLPLLAALIGIWNRNFLGYPTTAVIPYSQALERFPAHLQQLDMESNGKSVNRFGEPINFKTGPIIWGEPGTNGQHSFF 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 388 QLLHQGTDTIPLEFIVAAK---GHEPTLD--HQHEMLMANCLAQSEALMKGRtldearaqlqaknlpasqvERIAPHRVF 462
Cdd:PRK14095 392 QLLHQGTDIVPVEFIGFKEsqlGQDIVIQgsTSQQKLFANLIAQIIALACGK-------------------ENTNPNKNF 452
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 463 SGNRPSLTLIHDMLDPYTLGRLIALYEHRVFVEAQIFGINAFDQWGVELGKELATELLPVVSGKEgaSGRDASTQGLVAH 542
Cdd:PRK14095 453 KGNRPSSLLVAKQLTPYTLGALLAHYENKVMFQGFCWNINSFDQEGVQLGKVLANQILGIMKGEA--PGEFPEADGLLKL 530
|
.
gi 493111874 543 L 543
Cdd:PRK14095 531 F 531
|
|
| SIS_PGI_2 |
cd05016 |
Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification ... |
330-519 |
7.59e-79 |
|
Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of glucose 6-phosphate to fructose 6-phosphate. As an extracellular protein, PGI also has functions equivalent to neuroleukin (NLK), autocrine motility factor (AMF), and maturation factor (MF). Evidence suggests that PGI, NLK, AMF, and MF are closely related or identical. NLK is a neurotrophic growth factor that promotes regeneration and survival of neurons. The dimeric form of NLK has isomerase function, whereas its monomeric form carries out neurotrophic activity. AMF is a cytokine that stimulates cell migration and metastasis. MF mediates the differentiation of human myeloid leukemic HL-60 cells to terminal monocytic cells.
Pssm-ID: 240147 Cd Length: 164 Bit Score: 244.82 E-value: 7.59e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 330 SRAIIPYDQRLSRLPAYLQQLDMESNGKSVTLDGKPVsgPTGPVVWGEPGTNGQHAFFQLLHQGTDTIPLEFIVAAKGHE 409
Cdd:cd05016 2 THALLPYSQRLERFPAWLQQLDMESNGKSVTRDGEDY--PTGPIPWGAPGTNDQHSFFQLIHQGTKDKPVDFIAVKKPQN 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 410 PTLD-----HQHEMLMANCLAQSEALMkgrtldearaqlqaknlpasqveriaphrvFSGNRPSLTLIHDMLDPYTLGRL 484
Cdd:cd05016 80 DVLDylagkTLHDLLLANCLATREALM------------------------------FPGGRPSNTIVLPELTPYTLGAL 129
|
170 180 190
....*....|....*....|....*....|....*
gi 493111874 485 IALYEHRVFVEAQIFGINAFDQWGVELGKELATEL 519
Cdd:cd05016 130 LALYEHKTAVQGALLGINPFDQPGVELGKKLAKKI 164
|
|
| SIS_PGI_1 |
cd05015 |
Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification ... |
122-282 |
2.01e-72 |
|
Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of glucose 6-phosphate to fructose 6-phosphate. As an extracellular protein, PGI also has functions equivalent to neuroleukin (NLK), autocrine motility factor (AMF), and maturation factor (MF). Evidence suggests that PGI, NLK, AMF, and MF are closely related or identical. NLK is a neurotrophic growth factor that promotes regeneration and survival of neurons. The dimeric form of NLK has isomerase function, whereas its monomeric form carries out neurotrophic activity. AMF is a cytokine that stimulates cell migration and metastasis. MF mediates the differentiation of human myeloid leukemic HL-60 cells to terminal monocytic cells.
Pssm-ID: 240146 Cd Length: 158 Bit Score: 227.79 E-value: 2.01e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 122 VLDRMAAFADGIRSGalkgasgRKITDIVNIGIGGSDLGPVMATLALAPYHDEP-RAHFVSNIDGAHIADTLSPLDPAST 200
Cdd:cd05015 3 ELERIKEFAEKVRSG-------KKITDVVVIGIGGSDLGPRAVYEALKPYFKGGlRLHFVSNVDPDDLAELLKKLDPETT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 201 LIIVASKTFTTIETMTNAQTARKWVADTLGEaAVGAHFAAVSTALDKVAA-FGIPEDRVFGFWDWVGGRYSV-WSAIGLP 278
Cdd:cd05015 76 LFIVISKSGTTLETLANARLAREWLEEAGGD-DLAKHFVAITDNGSGLLKkAGIEGLNTFEIPDWVGGRFSVlSSVGGLP 154
|
....
gi 493111874 279 VMIA 282
Cdd:cd05015 155 LALA 158
|
|
| pgi |
PRK14096 |
glucose-6-phosphate isomerase; Provisional |
40-520 |
7.93e-57 |
|
glucose-6-phosphate isomerase; Provisional
Pssm-ID: 237609 [Multi-domain] Cd Length: 528 Bit Score: 198.57 E-value: 7.93e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 40 RYS--LCLDD---LLFDWSKCRVNDETMALLKEL---AVAAdvegrRAAMFAGEHINNTEDRAVLHVALRDTSskevLVD 111
Cdd:PRK14096 9 RYCdwLYYHPelgLWLDISRMNFDDAFLESLEPKfqkAFAA-----MAALEAGAIANPDEGRMVGHYWLRNPE----LAP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 112 GHNVLPDVKHVLDRMAAFADGIRSGALKGASGRKITDIVNIGIGGSDLGPVMATLALAPYHDEPRAHFVSNIDGAHIADT 191
Cdd:PRK14096 80 TPEIRAEITETLAQIEAFAAKVHSGTIKPPNGEKFTDVLWIGIGGSALGPQFVAEALQPNSDGLNIHFIDNTDPDGIDRV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 192 LSPLDP--ASTLIIVASKTFTTIET---MTNAQTARKwvadtlgeaAVGAHFAAVSTA-------LDKVAafgIPED--R 257
Cdd:PRK14096 160 LAELGDrlATTLVVVISKSGGTPETrngMLEAKAAYE---------AAGLDFASHAVAitmkgskLDQLA---QSEGwlA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 258 VFGFWDWVGGRYSVWSAIGLpVMIAVGPDNFRKFLAGAHAMDVHFRDAPLEKNLPVMLGLIgyWHRAICGYGSR--AIIP 335
Cdd:PRK14096 228 RFPMWDWVGGRTSETSAVGL-LPAALQGIDIRAFLAGAKQMDEATRVPDLKNNPAALLALA--WYYAGDGKGKKdmVVLP 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 336 YDQRL---SRlpaYLQQLDMESNGKSVTLDGKPVSgpTGPVVWGEPGTNGQHAFFQLLHQGTDTIPLEFIvaakgheptl 412
Cdd:PRK14096 305 YKDRLllfSR---YLQQLVMESLGKELDLDGNVVH--QGIAVYGNKGSTDQHAYVQQLRDGVDNFFVTFI---------- 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 413 dhqhEMLMANCLAQSEALMKGRTLDEARAQLQAKnlpasqveRIAphrVFSGNRPSLTLIHDMLDPYTLGRLIALYEHRV 492
Cdd:PRK14096 370 ----EVLEDRQGSSIEVEPGVTSGDYLSGFLQGT--------RQA---LYENGRQSITITIPEVNPRTLGALIALFERAV 434
|
490 500
....*....|....*....|....*...
gi 493111874 493 FVEAQIFGINAFDQWGVELGKELATELL 520
Cdd:PRK14096 435 GLYASLVNINAYHQPGVEAGKKAAAAIL 462
|
|
| PRK00973 |
PRK00973 |
glucose-6-phosphate isomerase; Provisional |
147-528 |
5.91e-44 |
|
glucose-6-phosphate isomerase; Provisional
Pssm-ID: 179193 [Multi-domain] Cd Length: 446 Bit Score: 161.70 E-value: 5.91e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 147 TDIVNIGIGGSDLGPVMATLALAPYH---------DEPRAHFVSNIDGAHIADTLSPLDPASTLIIVASKTFTTIETMTN 217
Cdd:PRK00973 72 DNVVVLGIGGSALGNLALHYALNPLNwnelskeerNGPRVFVLDNVDPEKTASILDVIDLEKTLFNVISKSGNTAETLAN 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 218 AQTARKWVaDTLGEAAVGaHFAAVSTA----LDKVA------AFGIPEDrvfgfwdwVGGRYSVWSAIGLPVMIAVGPDn 287
Cdd:PRK00973 152 YLIIRGIL-EKLGLDPKK-HLVFTTDPekgkLKKIAekegyrTLEIPEN--------VGGRFSVLTPVGLAPAAALGID- 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 288 FRKFLAGAHAMDVHFRDAPLEKNLPVMLGLIGYWH--RaicGYGSRAIIPYDQRLSRLPAYLQQLDMESNGKsvtlDGKp 365
Cdd:PRK00973 221 IEELLEGAKEMDKICEKEDIFKNPALLNALIHYLYynR---GKNISVMMPYSERLKYFGDWYRQLWAESLGK----KGV- 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 366 vsGPTgPVvwGEPGTNGQHAFFQLLHQGTDTIPLEFIVAAKGHE----PTLDHQHEMLmaNCLAqsealmkGRTLDEA-R 440
Cdd:PRK00973 293 --GQT-PV--KALGATDQHSQLQLYMEGPKDKIITFLKVEKYRRdveiPYEYEDIEEL--SYLG-------GHKLSELiN 358
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 441 AQLQAknlpasqVERIAPHRvfsgNRPSLTLIHDMLDPYTLGRLIALYEHRVFVEAQIFGINAFDQWGVELGKELATELL 520
Cdd:PRK00973 359 SEQKG-------TEIALTEN----GRPNVKITLDELNEYTVGQLFYMYEMQTAFMGELLNINAFDQPGVELGKKITYALL 427
|
....*...
gi 493111874 521 pvvsGKEG 528
Cdd:PRK00973 428 ----GRSG 431
|
|
| PRK03868 |
PRK03868 |
glucose-6-phosphate isomerase; Provisional |
145-520 |
6.84e-26 |
|
glucose-6-phosphate isomerase; Provisional
Pssm-ID: 235168 Cd Length: 410 Bit Score: 110.02 E-value: 6.84e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 145 KITDIVNIGIGGSDLGPVMATLALAPYHDEPRA-HFVSNIDGAHIADTLSPLDPASTLIIVASKTFTTIETMT------- 216
Cdd:PRK03868 57 SIKNIVVIGIGGSSLGVKAIYSFLKNEKNNKKElHFLENTDPISINKTLSKINLENTLFIVISKSGTTIETISifkylls 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 217 ----NAQTARKWVADTlGEAAVGAHFAAVstalDKVAAFGIPEDrvfgfwdwVGGRYSVWSAIGL-PVMIAvGPDnFRKF 291
Cdd:PRK03868 137 hfklDQELKKNFLFIT-DPDSKLEQFAKE----NNIKCFNIPKN--------VGGRFSVLSAVGIvPLALC-GYD-IKAL 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 292 LAGAHAMDVHFRDAPLEKNLPVMLGLIGYWHRaicgYGSRAIIPYDQRLSRLPAYLQQLDMESNGKsvtLDG-KPVSGPT 370
Cdd:PRK03868 202 LEGAKACKDSFFEQKEDHILKKAYFYATHKNA----YNINVLFSYSDALKGFNDWYVQLWGESLGK---KQGyKTRVGLT 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 371 gPVvwGEPGTNGQHAFFQLLHQGT----------------DTIP---LEFIvaakghePTLDHQ-----HEMLMANCLAQ 426
Cdd:PRK03868 275 -PI--GLIGSRDQHSFLQLIMEGPrdktvtfikikdfqnaPKIPnisLKGL-------ESLDFVngvsfNELINAQCDAT 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 427 SEALMkgrtldearaqlqAKNLPasqVERIaphrvfsgnrpslTLihDMLDPYTLGRLIALYEHRVFVEAQIFGINAFDQ 506
Cdd:PRK03868 345 MEALI-------------AEDIP---VDVI-------------TL--EKLDEFSIGYLIYYYELLTSAVGKMLGINTYDQ 393
|
410
....*....|....
gi 493111874 507 WGVELGKELATELL 520
Cdd:PRK03868 394 PGVEVGKRILKEKL 407
|
|
| PRK09533 |
PRK09533 |
bifunctional transaldolase/phosoglucose isomerase; Validated |
123-520 |
3.94e-24 |
|
bifunctional transaldolase/phosoglucose isomerase; Validated
Pssm-ID: 236551 [Multi-domain] Cd Length: 948 Bit Score: 106.98 E-value: 3.94e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 123 LDRMAAFADGIRsgalkgasGRKITDIVNIGIGGSDLGP-VMA-TLALAPYHdePRAHFVSNIDGAHIADTLSPLDPAST 200
Cdd:PRK09533 440 LAEYEAFAEEVR--------AEGFTDAVVLGMGGSSLGPeVLAeTFGQRDGF--PKLHVLDSTDPAQVRALEAAVDLART 509
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 201 LIIVASKTFTTIETMTNAQTARKWVADTLGEAAvGAHFAAVS---TALDKVAAfgipEDrvfGFWDW------VGGRYSV 271
Cdd:PRK09533 510 LFIVSSKSGGTLEPNIFKDYFFARVKEVLGAKA-GRHFVAVTdpgSSLEKVAK----ED---GFRKIfhgdpdIGGRYSV 581
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 272 WSAIGLPVMIAVGPDnFRKFLAGAHAMdVHF--RDAPLEKNLPVMLGLI-GywHRAICGYGSRAIIpYDQRLSRLPAYLQ 348
Cdd:PRK09533 582 LSPFGLVPAAAAGID-VRALLDSALAM-VRScgPSVPPADNPGVQLGLAlG--VAATQGRDKVTIV-ASPAIADFGAWAE 656
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 349 QLDMESNGKsvtlDGK---PVSGPTgpvvWGEPGTNGQHAFFqlLHQGTDTIPlefivaakgheptlDHQHEmlmancla 425
Cdd:PRK09533 657 QLIAESTGK----EGKgliPIDGEP----LGDPAVYGNDRVF--VYLRLAGEA--------------DAAQD-------- 704
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 426 qsealmkgrtldearAQLQAknlpasqVERiAPHRVFSgnrpsltliHDMLDPYTLGRLIALYEHRVFVEAQIFGINAFD 505
Cdd:PRK09533 705 ---------------AALAA-------LEA-AGHPVVR---------IVLDSAEQLGQEFFRWEMATAVAGAVLGINPFD 752
|
410
....*....|....*
gi 493111874 506 QWGVELGKELATELL 520
Cdd:PRK09533 753 QPDVEASKIKTRELT 767
|
|
| pgi |
PRK14097 |
glucose-6-phosphate isomerase; Provisional |
123-528 |
8.92e-15 |
|
glucose-6-phosphate isomerase; Provisional
Pssm-ID: 184504 Cd Length: 448 Bit Score: 76.42 E-value: 8.92e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 123 LDRMAAFADGIRSgalkgasgrKITDIVNIGIGGSDLGPVMATLALA-PYHDE--------PRAHFVSN-IDGAHIADTL 192
Cdd:PRK14097 59 FARIKKAAEKIKS---------DSDVLVVIGIGGSYLGARAAIEFLNhSFYNLlpkeqrkaPQIIFAGNsISSTYLADLL 129
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90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 193 SPLDPASTLIIVASKTFTTIETMTNAQTARKWVADTLG-EAAVGAHFA---AVSTALDKVA------AFGIPEDrvfgfw 262
Cdd:PRK14097 130 EYLKDKDFSINVISKSGTTTEPAIAFRIFKELLEKKYGkEEAKKRIYAttdKAKGALKTLAdaegyeTFVIPDD------ 203
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170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 263 dwVGGRYSVWSAIGLPVMIAVGPDnFRKFLAGAHAMDVHFRDAPLEKNLPVMLGLIGYW-HRAicGYGSRAIIPYDQRLS 341
Cdd:PRK14097 204 --VGGRFSVLTAVGLLPIAVAGID-IDALMKGAADARKDYSSSDLSENPAYQYAAVRNIlYRK--GYTTEILVNYEPSLQ 278
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250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 342 RLPAYLQQLDMESNGKsvtlDGKpvsG--PTGPVVwgepgTNGQHAFFQLLHQGTDTIpLEFIVAAKG--HEPTLDHQHE 417
Cdd:PRK14097 279 YFSEWWKQLFGESEGK----DQK---GifPASANF-----STDLHSLGQYIQEGRRNL-FETVIKVEKprKDLTIPEDEE 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493111874 418 MLMA-NCLAqsealmkGRTLDEAraqlqakNLPASQVERIApHrvFSGNRPSLTLIHDMLDPYTLGRLIALYEHRVFVEA 496
Cdd:PRK14097 346 DLDGlNYLA-------GKTVDFV-------NKKAFEGTLLA-H--TDGGVPNIVVNIPELDEYTFGYLVYFFEKACAISG 408
|
410 420 430
....*....|....*....|....*....|..
gi 493111874 497 QIFGINAFDQWGVELGKELATELLpvvsGKEG 528
Cdd:PRK14097 409 YLLGVNPFDQPGVEAYKKNMFALL----GKPG 436
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| SIS_TAL_PGI |
cd05798 |
SIS_TAL_PGI: Transaldolase (TAL)/ Phosphoglucose isomerase (PGI). This group represents the ... |
471-519 |
2.36e-03 |
|
SIS_TAL_PGI: Transaldolase (TAL)/ Phosphoglucose isomerase (PGI). This group represents the SIS (Sugar ISomerase) PGI domain, of a multifunctional protein (TAL-PGI ) having both TAL and PGI activities. TAL_PGI contains an N-terminal TAL domain and a C-terminal PGI domain. TAL catalyzes the reversible conversion of sedoheptulose-7-phosphate (S7P) and glyceraldehyde-3-phosphate (G3P), to fructose-6-phosphate (F6P) and erythrose-4-phosphate (E4P). PGI catalyzes the reversible isomerization of F6P to glucose-6-phosphate (G6P). It has been suggested for Gluconobacter oxydans TAL_PGI that this enzyme generates E4P and G6P directly from S7P and G3P. G. oxydans TAL_PGI contributes to increased xylitol production from D-arabitol. As xylitol is an alternative natural sweetner to sucrose, the microbial conversion of D-arabitol to xylitol is of interest to food and pharmaceutical industries.
Pssm-ID: 240224 [Multi-domain] Cd Length: 129 Bit Score: 38.20 E-value: 2.36e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 493111874 471 LIHDMLDPYTLGRLIALYEHRVFVEAQIFGINAFDQWGVELGKELATEL 519
Cdd:cd05798 81 IRIDLDDAYDLGQEFFRWEMATAVAGAVLGINPFDQPDVEASKIETRRL 129
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