|
Name |
Accession |
Description |
Interval |
E-value |
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
3-973 |
0e+00 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 1162.53 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 3 DLSDQYTPADIESVVGDYWDEENAYEATKEAHADDPAFFFVDGPPYTSGQMHLGTAWNKTLKDAIIRYKRMTGHRVTDRP 82
Cdd:COG0060 11 DFPMRANLPKREPEILKFWEENDIYEKSREARAGRPKFVLHDGPPYANGDIHIGHALNKILKDIIVRYKTMRGFDVPYVP 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 83 GYDMHGLPIEVKVEEELGFeTKRDIEEYGMESFIDECKSFAERNREAMDDDFQSIGVWMDWDDPYKTLSPEYMEAAWWAF 162
Cdd:COG0060 91 GWDCHGLPIELKVEKELGI-KKKDIEKVGIAEFREKCREYALKYVDEQREDFKRLGVWGDWDNPYLTMDPEYEESIWWAL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 163 DQVADRGLVERGKRSVNYCPRCQTAIAANEVEYDEIDSPSIYVKFPLEDREG-------SLVIWTTTPWTIPANTFVAVD 235
Cdd:COG0060 170 KKLYEKGLLYKGLKPVPWCPRCGTALAEAEVEYKDVTSPSIYVKFPVKDEKAlllledaYLVIWTTTPWTLPANLAVAVH 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 236 GEMTYQAVRAEKGgesEVLYLAEPCVEDVLKKGRYEDYEVVEELSGEEMVGWEYDNPLAGhlneYADFEGAGEVYTAEYV 315
Cdd:COG0060 250 PDIDYVLVEVTGG---ERLILAEALVEAVLKELGIEDYEVLATFKGAELEGLRYEHPFYY----VVGYDRAHPVILGDYV 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 316 EA-DRTGLVHSAPGHGQEDFARGQDLGLDVFVPVDGRGEFTEQAGDYAGTFVRDANPDIIEDLEADGSLLHSGEHSHRYG 394
Cdd:COG0060 323 TTeDGTGIVHTAPGHGEDDFEVGKKYGLPVLNPVDDDGRFTEEAPLFAGLFVKDANPAIIEDLKERGALLAREKITHSYP 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 395 HCWRCDTDIIFLATDQWFITVTDVKDELLDNIEDSEWHPQWaRDNRFRDFVADAPDWNISRQRYWGIPLPIWESED-GE- 472
Cdd:COG0060 403 HCWRCKTPLIYRATPQWFISMDKLRDRALEAIEKVNWIPEW-GEGRFGNMLENRPDWCISRQRYWGVPIPIWVCEDcGEl 481
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 473 --DFIVVGTREELAERADQDVdPGELDLHRPSVDP-LTITEDGTTYERVPDVFDVWIDSSVATWGTLdypgnETDFEELW 549
Cdd:COG0060 482 hrTEEVIGSVAELLEEEGADA-WFELDLHRPFLDEtLKCPKCGGTMRRVPDVLDVWFDSGSMHFAVL-----ENREELHF 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 550 PADLIVEAHDQTRGWFWSQLGMGTAARGEIPYEEVLMHGFANDENGRKMSKSLGNIVTPEEAIDRAGRDPLRAYLLSHDQ 629
Cdd:COG0060 556 PADFYLEGSDQTRGWFYSSLLTSTALFGRAPYKNVLTHGFVLDEDGRKMSKSLGNVVDPQEVIDKYGADILRLWVASSDY 635
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 630 QGvDLSFDWDGLADTQSALNIFWNVFRFPLpyMELDGYDPANPDLSAGELSVVDEWVLSRLQTVKADVADAWDDYEVHDA 709
Cdd:COG0060 636 WG-DLRFSDEILKEVRDVYRRLRNTYRFLL--ANLDDFDPAEDAVPYEDLPELDRWILSRLNELIKEVTEAYDNYDFHRA 712
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 710 LNAILDFVTEDVSRFYVKAIRERMW-EEEDSESKRGAYATLATVLNETVQLIAPFTPYVAERMYQHLDGS-ETTVHALDY 787
Cdd:COG0060 713 YRALHNFCVEDLSNWYLDISKDRLYtEAADSLDRRAAQTTLYEVLETLVRLLAPILPFTAEEIWQNLPGEaEESVHLADW 792
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 788 PTVDEAWRDEELERNMAVLRNVEEAAA----NARQQGerKLRWPVQRVVVASEDDEVAEAVEALSDLLADRVNTRTIEVV 863
Cdd:COG0060 793 PEVDEELIDEELEAKWDLVREVRSAVLkaleAARKEK--LIRQPLEAAVVLYADEELAAALESLGDLLAEELNVSEVELV 870
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 864 EtfdelveyadpqmgvIGPAFGGDAQKVMqavkgvpreevesgvEVDGETVELTDEmveyraeppenvydaefAATDGTD 943
Cdd:COG0060 871 D---------------DAEDLGKDALKAL---------------DVEGISVTVEVE-----------------KADGEKC 903
|
970 980 990
....*....|....*....|....*....|
gi 492946146 944 GGVVYVDTSLTEeiEAEGYARDVIRRIQEM 973
Cdd:COG0060 904 ERCWHYEVGWTP--EHEGLCRRCVRRVQGL 931
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
7-845 |
0e+00 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 931.02 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 7 QYTPADIESVVGDYWDEENAYEATKEAHADDPAFFFVDGPPYTSGQMHLGTAWNKTLKDAIIRYKRMTGHRVTDRPGYDM 86
Cdd:TIGR00392 5 RGNLSKREEKILAFWQENDIFEKVKKLNKGKPEFIFHDGPPYANGSIHLGHALNKILKDIILRYKTMQGFNVTRKPGWDT 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 87 HGLPIEVKVEEELGFETKRDIEEYGMESFIDECKSFAERNREAMDDDFQSIGVWMDWDDPYKTLSPEYMEAAWWAFDQVA 166
Cdd:TIGR00392 85 HGLPIEHKVEKKLGISGKKEISSLEIEEFREKCREFALKQIEEQREQFQRLGVWGDWENPYKTMDPSYEESQWWLFKEAH 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 167 DRGLVERGKRSVNYCPRCQTAIAANEVEYDE----IDSPSIYVKFPLEDRE--------GSLVIWTTTPWTIPANTFVAV 234
Cdd:TIGR00392 165 EKGLLYRGLKPVYWSPRCRTALAEAEVEYKEnykdVKDPSIYVKFPVKKDKktylkvklSSLLIWTTTPWTLPSNLAIAV 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 235 DGEMTYQAVRAEkgGESEVLYLAEPCVEDVLKKGRyEDYEVVEELSGEEMVGWEYDNPLAGHLNEYAdfEGAGEVYTAEY 314
Cdd:TIGR00392 245 HPDFEYALVQDN--TKVEYFILAKKLVEKLYNKAG-SDYEIIKTFKGSDLEGLEYEHPLYDFVSQLK--EGAPVVIGGDH 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 315 VEADR-TGLVHSAPGHGQEDFARGQDLGLDVFVPVDGRGEFTEQAGDYAGTFVRDANPD-------IIEDLEADGSLLHS 386
Cdd:TIGR00392 320 VTTEDgTGIVHTAPGHGEEDYEIGKKYGLEVLSPVDEKGVYTEGVNDFQGRFVKDADKDiikankiIIEQLKDKGLLLKA 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 387 GEHSHRYGHCWRCDTDIIFLATDQWFITVTDVKDELLDNIEDSEWHPQWARdNRFRDFVADAPDWNISRQRYWGIPLPIW 466
Cdd:TIGR00392 400 EKITHSYPHCWRTKTPVIYRATEQWFIKTKDIKDQMLEQIKKVNWVPEWGE-GRFGNWLENRPDWCISRQRYWGIPIPIW 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 467 ESEDGEDFIVVGTREELAERADQ-DVDPGELDLHRPSVDPLTIT-EDGTTYERVPDVFDVWIDSSVATWGTLDYPGNETD 544
Cdd:TIGR00392 479 YCEDTGEPIVVGSIEELIELIELkGIDAWFEDLHRDFLDKITLKsGDGGEYRRVPDVLDVWFDSGSMPYASIHYPFENEK 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 545 FEELWPADLIVEAHDQTRGWFWSQLGMGTAARGEIPYEEVLMHGFANDENGRKMSKSLGNIVTPEEAIDRAGRDPLRAYL 624
Cdd:TIGR00392 559 FKEVFPADFILEGSDQTRGWFYSSLAIGTALFGQAPYKNVITHGFTLDEKGRKMSKSLGNVVDPLKVINKYGADILRLYV 638
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 625 LSHDQQGvDLSFDWDGLADTQSAL-NIFWNVFRFPLPYMELDGYDPANPDLSAGELSVVDEWVLSRLQTVKADVADAWDD 703
Cdd:TIGR00392 639 ASSDPWE-DLRFSDEILKQVVEKYrKIRWNTYRFLLTYANLDKFDPLFNSVAVEKFPEEDRWILSRLNSLVEEVNEALEK 717
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 704 YEVHDALNAILDFVTEDVSRFYVKAIRERMWEEEDSESKRGAYATLATVLNETVQLIAPFTPYVAERMYQHL--DGSETT 781
Cdd:TIGR00392 718 YNFHKVLRALQDFIVEELSNWYIRIIRDRLYCEAKDNDKRAAQTTLYYALLTLVRLLAPFLPHTAEEIYQNLpgGEEEES 797
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 492946146 782 VHALDYPTVDEAWRDEELERNMAVLRNVEEAAANARQQGERKLRWPVQRVVVASEDDEVAEAVE 845
Cdd:TIGR00392 798 VHLNLWPEVDEEFIDEALEANMAIVREIVEAFLALRDAANKKLRQPLKELVIGKSLEAVLKAVE 861
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
7-1044 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 609.42 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 7 QYTPADIESVVGDYWDEENAYEATKEAHADDPAFFFVDGPPYTSGQMHLGTAWNKTLKDAIIRYKRMTGHRVTDRPGYDM 86
Cdd:PLN02882 7 DFSFPKQEEKILSLWSEIDAFKTQLKRTEGLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWDC 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 87 HGLPIEVKVEEELGFETKRDIEEYGMESFIDECKSFAERNREAMDDDFQSIGVWMDWDDPYKTLSPEYMEAAWWAFDQVA 166
Cdd:PLN02882 87 HGLPVEYEIDKKLGIKRRDDVLKMGIDKYNEECRSIVTRYSKEWEKTVTRTGRWIDFENDYKTMDPKFMESVWWVFKQLF 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 167 DRGLVERGKRSVNYCPRCQTAIAANEV--EYDEIDSPSIYVKFPL--EDREGSLVIWTTTPWTIPANTFVAVDGEMTYQA 242
Cdd:PLN02882 167 EKGLVYKGFKVMPYSTACKTPLSNFEAglNYKDVSDPAVMVSFPIvgDPDNASFVAWTTTPWTLPSNLALCVNPNFTYVK 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 243 VRAEKGGEseVLYLAE------PCVEDVLKKGRY-----EDYEVVEELSGEEMVGWEYDnPLAGHLNEYADfeGAGEVYT 311
Cdd:PLN02882 247 VRNKYTGK--VYIVAEsrlsalPTAKPKSKKGSKpenaaEGYEVLAKVPGSSLVGKKYE-PLFDYFSEFSD--TAFRVVA 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 312 AEYVEADR-TGLVHSAPGHGQEDF---------ARGQDLgldvFVPVDGRGEFTEQAGDYAGTFVRDANPDIIEDLEADG 381
Cdd:PLN02882 322 DDYVTDDSgTGVVHCAPAFGEDDYrvclangiiEKGGNL----PVPVDDDGCFTEKVTDFSGRYVKDADKDIIAAIKAKG 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 382 SLLHSGEHSHRYGHCWRCDTDIIFLATDQWFITVTDVKDELLDNIEDSEWHPQWARDNRFRDFVADAPDWNISRQRYWGI 461
Cdd:PLN02882 398 RLVKSGSITHSYPFCWRSDTPLIYRAVPSWFVKVEEIKDRLLENNKQTYWVPDYVKEKRFHNWLENARDWAVSRSRFWGT 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 462 PLPIWESEDGEDFIVVGTREELAERADQDVDpgelDLHRPSVDPLTI----TEDGTTYERVPDVFDVWIDSSVATWGTLD 537
Cdd:PLN02882 478 PLPIWISDDGEEVVVIGSIAELEKLSGVKVT----DLHRHFIDHITIpssrGPEFGVLRRVDDVFDCWFESGSMPYAYIH 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 538 YP-GNETDFEELWPADLIVEAHDQTRGWFWSQLGMGTAARGEIPYEEVLMHGFANDENGRKMSKSLGNIVTPEEAIDRAG 616
Cdd:PLN02882 554 YPfENKELFEKNFPADFVAEGLDQTRGWFYTLMVLSTALFDKPAFKNLICNGLVLAEDGKKMSKSLKNYPDPNEVIDKYG 633
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 617 RDPLRAYLL-SHDQQGVDLSFDWDGLADTQSALNIFW-NVFRFPLP---YMELDGYDPANP-DLSAGELS--VVDEWVLS 688
Cdd:PLN02882 634 ADALRLYLInSPVVRAEPLRFKEEGVFGVVKDVFLPWyNAYRFLVQnakRLEVEGGAPFVPlDLAKLQNSanVLDRWINS 713
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 689 RLQTVKADVADAWDDYEVHDALNAILDFVTEdVSRFYVKAIRERMWEEEDSESKRGAYATLATVLNETVQLIAPFTPYVA 768
Cdd:PLN02882 714 ATQSLVKFVREEMGAYRLYTVVPYLVKFIDN-LTNIYVRFNRKRLKGRTGEEDCRTALSTLYNVLLTSCKVMAPFTPFFT 792
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 769 ERMYQHL----DGSETTVHALDYPTVDEAWRDEELERNMAVLRNVEEAAANARQQGERKLRWPVQRVVVASEDDEVAEAV 844
Cdd:PLN02882 793 EVLYQNLrkvlPGSEESIHYCSFPQVDEGELDERIEQSVSRMQTVIELARNIRERHNKPLKTPLKEMVVVHPDAEFLDDI 872
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 845 -EALSDLLADRVNTRTIEVVEtfDELvEY----ADPQMGVIGPAFGGDAQKVMQAVKGVPREEV----ESG-VEVDGETV 914
Cdd:PLN02882 873 tGKLKEYVLEELNVRSLVPCN--DPL-KYaslrAEPNFSVLGKRLGKSMGLVAKEVKAMSQDDIlefeKAGeVTIAGHTL 949
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 915 ELTDEMVEYRAEPPENVYDAEFAATdGTDGGVVYVDTSLTEEIEAEGYARDVIRRIQEMRKRLSLDVEEEIAVSLDVQDD 994
Cdd:PLN02882 950 KAGDIKVVRDFKRPEGVSKEDIDAA-GDGDVLVILDLRVDESLLEAGVAREVVNRIQKLRKKAGLEPTDKVEVFFESLDE 1028
|
1050 1060 1070 1080 1090
....*....|....*....|....*....|....*....|....*....|....*....
gi 492946146 995 R----VADLVYRHEDLIAE----EVRATTLNSDGEDADLTEEW-DIEGVTVVISIAQTA 1044
Cdd:PLN02882 1029 VdesaLSQVLKSQAQYIREslgsPLLPSSMMPSHAVVIAEESFhGVSGLSFKISLARPA 1087
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
19-637 |
0e+00 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 599.40 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 19 DYWDEENAYEATKEAHADDPAFFFVDGPPYTSGQMHLGTAWNKTLKDAIIRYKRMTGHRVTDRPGYDMHGLPIEVKVEEE 98
Cdd:pfam00133 4 EFWDEQGYFKPELEKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVVEKK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 99 LGFETKRDIEEYGMESFIDECKSFAERNREAMDDDFQSIGVWMDWDDPYKTLSPEYMEAAWWAFDQVADRGLVERGKRSV 178
Cdd:pfam00133 84 LGIKEKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGKKLV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 179 NYCPRCQTAIAANEVEYDEIDSPSIYVKFPLEDREG-SLVIWTTTPWTIPANTFVAVDGEMTYqavraekGGESEVLYLA 257
Cdd:pfam00133 164 NWSPALNTALSNLEVEYKDVKGPSIHVAFPLADDEGaSLVIWTTTPWTLPGNTAVAVNPEFDY-------VITGEGYILA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 258 EPCVEDVLKKGryEDYEVVEELSGEEMVGWEYDNPLAGhlneyadfeGAGEVYTAEYVEADR-TGLVHSAPGHGQEDFAR 336
Cdd:pfam00133 237 EALLKSLYKKG--TDKKILEDFRGKELEGKEAIHPFVN---------REIPIITDDYVDMEFgTGAVHIAPAHGENDYEV 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 337 GQDLGLDVFVPVDGRGEFTEQAGDYAGTFVRDANPDIIEDLEADGSLLHSGEHSHRYGHCWRCDTDIIFLATDQWFITVT 416
Cdd:pfam00133 306 GQRHNLEVINPVDDDGTFTEEAPDFQGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRATPQWFVRMD 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 417 DVKDELLDNIEDSEWHPQWaRDNRFRDFVADAPDWNISRQRYWGIPLPIWESEDGEDFIVVGTREELAERADQDVDpGEL 496
Cdd:pfam00133 386 ELADQALEAVEKVQFVPKS-GEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDTEEVVCRGELFELVAGRFEEEG-SIK 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 497 DLHRPSVDPLTITEDgtTYERVPDVFDVWIDSSVATWGTLDYPGNET-DFEELWPADLIVEAHDQTRGWFWSQLGMGTAA 575
Cdd:pfam00133 464 WLHREAKDKLGYGKG--TLEQDEDVLDTWFSSGSWPFSTLGWPFVNTeEFKKFFPADMLLEGSDQTRGWFYRMIMLSTAL 541
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 492946146 576 RGEIPYEEVLMHGFANDENGRKMSKSLGNIVTPEEAIDRAGRDPLRAYLLSHDqQGVDLSFD 637
Cdd:pfam00133 542 TGSVPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVIDKYGADALRLWLANSD-YGRDINLS 602
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
6-936 |
1.44e-171 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 524.62 E-value: 1.44e-171
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 6 DQYTPADIESVVGDYWDEENAYEAtkEAHADDPAFFFVDGPPYTSGQMHLGTAWNKTLKDAIIRYKRMTGHRVTDRPGYD 85
Cdd:TIGR00422 3 KDYDPHEVEKKWYKKWEKSGFFKP--DGNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 86 MHGLPIEVKVEEELGFETKRDiEEYGMESFIDECKSFAERNREAMDDDFQSIGVWMDWDDPYKTLSPEYMEAAWWAFDQV 165
Cdd:TIGR00422 81 HAGIATQVKVEKKLGAEGKTK-HDLGREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFVRL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 166 ADRGLVERGKRSVNYCPRCQTAIAANEVEYDEIDSPSIYVKFPLED-REGSLVIWTTTPWTIPANTFVAVDgemtyqavr 244
Cdd:TIGR00422 160 YEKGLIYRGEYLVNWDPKLNTAISDIEVEYKEVKGKLYYIRYPLANgSKDYLVVATTRPETMFGDTAVAVH--------- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 245 aekggesevlylaePcvEDvlkkGRYEdyevveelsgeEMVGWEYDNPLAGHLNEyadfegageVYTAEYVEADR-TGLV 323
Cdd:TIGR00422 231 --------------P--ED----ERYK-----------HLIGKKVILPLTGRKIP---------IIADEYVDMEFgTGAV 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 324 HSAPGHGQEDFARGQDLGLDVFVPVDGRGEFTEQAGDYAGTFVRDANPDIIEDLEADGSLLHSGEHSHRYGHCWRCDTDI 403
Cdd:TIGR00422 271 KVTPAHDFNDYEWGKRHNLEFINILDEDGLLNENAGKYQGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVGTCWRSGTVV 350
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 404 IFLATDQWFITVTDVKDELLDNIEDSE--WHP-QWarDNRFRDFVADAPDWNISRQRYWGIPLPIW-ESEDGEdfIVVGT 479
Cdd:TIGR00422 351 EPLLSKQWFVKVEKLADKALEAAEEGEikFVPkRM--EKRYLNWLRNIKDWCISRQLIWGHRIPVWyCKECGE--VYVAK 426
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 480 REelaeradqdvdpgeldlhrPSVDPLTITEDGTTYERVPDVFDVWIDSSVATWGTLDYPGNETDFEELWPADLIVEAHD 559
Cdd:TIGR00422 427 EE-------------------PLPDDKTNTGPSVELEQDTDVLDTWFSSSLWPFSTLGWPDETKDLKKFYPTDLLVTGYD 487
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 560 QTRGWFWSQLGMGTAARGEIPYEEVLMHGFANDENGRKMSKSLGNIVTPEEAIDRAGRDPLRAYLLSHDQQGVDLSFDWD 639
Cdd:TIGR00422 488 IIFFWVARMIFRSLALTGQVPFKEVYIHGLVRDEQGRKMSKSLGNVIDPLDVIEKYGADALRFTLASLVTPGDDINFDWK 567
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 640 GLADTQSALNIFWNVFRFPLpyMELDGYDPANPDLsaGELSVVDEWVLSRLQTVKADVADAWDDYEVHDALNAILDFVTE 719
Cdd:TIGR00422 568 RVESARNFLNKLWNASRFVL--MNLSDDLELSGGE--EKLSLADRWILSKLNRTIKEVRKALDKYRFAEAAKALYEFIWN 643
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 720 DVSRFYVKAIRERMWeEEDSESKRGAYATLATVLNETVQLIAPFTPYVAERMYQHLDGSETTVHALDYPTVDEAWRDEEL 799
Cdd:TIGR00422 644 DFCDWYIELVKYRLY-NGNEAEKKAARDTLYYVLDKALRLLHPFMPFITEEIWQHFKEGADSIMLQSYPVVDAEFVDEEA 722
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 800 ERNMAVLRNVEEAAANARQQGERKLRWPVQrVVVASEDDEVAEAVEALSDLLADRVNTRTIEVVETFDELVEYAD---PQ 876
Cdd:TIGR00422 723 EKAFELLKEIIVSIRNLKAESNIPPNAPLK-VLLIYTEAETAERLKLNAVDIKGAINFSEVEVVIEKPEVTEAVVelvPG 801
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 492946146 877 MGVIGPAFG--GDAQKVMQAVKGVPREEVESgvevdgETVELTDEMVEYRAEPPENVYDAEF 936
Cdd:TIGR00422 802 FEIIIPVKGliNKAKELARLQKQLDKEKKEV------IRIEGKLENEGFVKKAPKEVIEKEK 857
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
20-879 |
2.33e-148 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 467.33 E-value: 2.33e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 20 YWDEENAYEATKEAhADDPAFFFVDGPPYTSGQMHLGTAWNKTLKDAIIRYKRMTGHRVTDRPGYDMHGLPIEVKVEEEL 99
Cdd:PLN02843 15 LWEENQVYKRVSDR-NNGESFTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIELKVLQSL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 100 GFETKRDIEEYGMESfidECKSFAERNREAMDDDFQSIGVWMDWDDPYKTLSPEYMEAAWWAFDQVADRGLVERGKRSVN 179
Cdd:PLN02843 94 DQEARKELTPIKLRA---KAAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNGYIYRGRKPVH 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 180 YCPRCQTAIAANEVEYDEID-SPSIYVKFPL---------EDRE----GSLVIWTTTPWTIPANTFVAVDGEMTYQAVRA 245
Cdd:PLN02843 171 WSPSSRTALAEAELEYPEGHvSKSIYVAFPVvspsetspeELEEflpgLSLAIWTTTPWTMPANAAVAVNDKLQYSVVEV 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 246 EKGGESEV---------------------LYLAEPCVEDVLKKGRYEdYEVVEELSGEEMVGWEYDNPLAGHLNEYadfe 304
Cdd:PLN02843 251 QSFSEDEStsggnkkkrpgnvlkeqqklfLIVATDLVPALEAKWGVK-LVVLKTFPGSDLEGCRYIHPLYNRESPV---- 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 305 gageVYTAEYVEADR-TGLVHSAPGHGQEDFARGQDLGLDVFVPVDGRGEFTEQAGDYAGTFVR-DANPDIIEDLEADGS 382
Cdd:PLN02843 326 ----VIGGDYITTESgTGLVHTAPGHGQEDYITGLKYGLPLLSPVDDAGKFTEEAGQFSGLSVLgEGNAAVVEALDEAGS 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 383 LLHSGEHSHRYGHCWRCDTDIIFLATDQWFITVTDVKDELLDNIEDSEWHPQWArDNRFRDFVADAPDWNISRQRYWGIP 462
Cdd:PLN02843 402 LLMEEAYGHKYPYDWRTKKPTIFRATEQWFASVEGFRQAALDAIDKVKWIPAQG-ENRIRAMVSGRSDWCISRQRTWGVP 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 463 LPIwesedgedFIVVGTREELAER----------ADQDVDP-GELDLhrpsVD--PLTITEDGTTYERVPDVFDVWIDSS 529
Cdd:PLN02843 481 IPV--------FYHVETKEPLMNEetiahvksivAQKGSDAwWYMDV----EDllPEKYRDKASDYEKGTDTMDVWFDSG 548
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 530 VATWGTLdypgnETDFEELWPADLIVEAHDQTRGWFWSQLGMGTAARGEIPYEEVLMHGFANDENGRKMSKSLGNIVTPE 609
Cdd:PLN02843 549 SSWAGVL-----GSREGLSYPADLYLEGSDQHRGWFQSSLLTSVATKGKAPYKSVLTHGFVLDEKGFKMSKSLGNVVDPR 623
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 610 EAIDRA---------GRDPLRAYLLSHDQQGvDLSFDWDGLADTQSALNIFWNVFRFPLPymELDGYDPANpDLSAGELS 680
Cdd:PLN02843 624 LVIEGGknqkqepayGADVLRLWVASVDYTG-DVLIGPQILKQMSDIYRKLRGTLRYLLG--NLHDWKPDN-AVPYEDLP 699
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 681 VVDEWVLSRLQTVKADVADAWDDYEVHDALNAILDFVTEDVSRFYVKAIRERMWEEEDSESKRGAYAT-LATVLNETVQL 759
Cdd:PLN02843 700 SIDKYALFQLENVVNEIEESYDNYQFFKIFQILQRFTIVDLSNFYLDVAKDRLYVGGTTSFTRRSCQTvLAAHLLSLLRA 779
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 760 IAPFTPYVAERMYQHL----DGSET-TVHALDYPTVDEAW---RDEE-------LERNMAVLRnVEEAAANARQQG---E 821
Cdd:PLN02843 780 IAPILPHLAEDAWQNLpfqeDGSAAeSVFEAGWPTPNEEWlsfPAEDvdfwsllLEVRDEVNK-VLESARNGKLIGaslE 858
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 492946146 822 RKlrwpvqrVVVASEDDEVAEAVEALS------DLLADRVNTRTIEVVETFDELVEYADPQMGV 879
Cdd:PLN02843 859 AK-------VYLHASDASLAARLAELCgasngaDELRRIFITSQVEVVSSEDDETAACGSYTGE 915
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
1-871 |
1.28e-144 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 452.34 E-value: 1.28e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 1 MDDLSDQYTPADIESVVGDYWDEENAYeATKEAHADDPafFFVDGPP-YTSGQMHLGTAWNKTLKDAIIRYKRMTGHRVT 79
Cdd:PRK13208 3 MPELPKKYDPEELEEKWQKIWEEEGTY-KFDPDERKPV--YSIDTPPpTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 80 DRPGYDMHGLPIEVKVEEELGFeTKRDIEEygmESFIDECKSFAERNREAMDDDFQSIGVWMDWDDPYKTLSPEYMEAAW 159
Cdd:PRK13208 80 FPQGWDDNGLPTERKVEKYYGI-RKDDISR---EEFIELCRELTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQ 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 160 WAFDQVADRGLVERGKRSVNYCPRCQTAIAANEVEYDEIDSPSIYVKFPLEDREGsLVIWTTTPWTIPANtfVAVdgemt 239
Cdd:PRK13208 156 KSFLDLYKKGLIYRAEAPVLWCPRCETAIAQAEVEYREREGKLNYIKFPVEDGEE-IEIATTRPELLPAC--VAV----- 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 240 yqavraekggesevlyLAEPcvEDVlkkgRYEDY---EVVEELSGEEMvgweydnPLAGHlnEYADFE-GAGEVYTAEYv 315
Cdd:PRK13208 228 ----------------VVHP--DDE----RYKHLvgkTAIVPLFGVEV-------PILAD--PLVDPDfGTGAVMICTF- 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 316 eADRTglvhsapghgqeDFARGQDLGLDVFVPVDGRGEFTEQAGDYAGTFVRDANPDIIEDLEADGSLLHSGEHSHRYGH 395
Cdd:PRK13208 276 -GDKT------------DVTWWRELNLPTRIIIDEDGRMTEAAGKLAGLTIEEARKKIVEDLKSGGLLGKQEPIKHNVKF 342
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 396 CWRCDTDIIFLATDQWFITVTDVKDELLDNIEDSEWHPQWARdNRFRDFVAD-APDWNISRQRYWGIPLPIWESEDgEDF 474
Cdd:PRK13208 343 CERCDTPLEILVTRQWFIKVLDLKEELLERGKEINWYPEHMR-VRLENWIEGlNWDWCISRQRYFGTPIPVWYCKD-CGH 420
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 475 IVVGTREELAERADQDVDPGELDLHRpsvdpltiteDGTTYERVPDVFDVWIDSS-----VATWGTldypgNETDFEELW 549
Cdd:PRK13208 421 PILPDEEDLPVDPTKDEPPGYKCPQC----------GSPGFEGETDVMDTWATSSitpliVTGWER-----DEDLFEKVF 485
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 550 PADLIVEAHDQTRGWFWSqlgmgTAAR-----GEIPYEEVLMHGFANDENGRKMSKSLGNIVTPEEAIDRAGRDPLRaYL 624
Cdd:PRK13208 486 PMDLRPQGHDIIRTWLFY-----TILRaylltGKLPWKNIMISGMVLDPDGKKMSKSKGNVVTPEELLEKYGADAVR-YW 559
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 625 LSHDQQGVDLSFDWDGLADTQSALNIFWNVFRFPLPYMELDGYDPANpdlsagELSVVDEWVLSRLQTVKADVADAWDDY 704
Cdd:PRK13208 560 AASARLGSDTPFDEKQVKIGRRLLTKLWNASRFVLHFSADPEPDKAE------VLEPLDRWILAKLAKVVEKATEALENY 633
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 705 EVHDALNAILDFVTEDVSRFYVKAIRERMWEEEDSESKRGAYATLATVLNETVQLIAPFTPYVAERMYQHLDGSetTVHA 784
Cdd:PRK13208 634 DFAKALEEIESFFWHVFCDDYLELVKSRAYGEDEEEEQKSARYTLYTVLDTLLRLLAPFLPFITEEVWSWLYGG--SVHR 711
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 785 LDYPTVDEAWRDEELERN----MAVLRNVEEAAANARQqgerKLRWPVQRVVVASedDEVAEAVEALSDLLADRVNTRTI 860
Cdd:PRK13208 712 ASWPEPDEELIDEEDEELgelaKEILSAVRKYKSEAGL----SLNAPLKKVEVYG--PADLELLEAAEEDLKAAGNIEEL 785
|
890
....*....|.
gi 492946146 861 EVVETFDELVE 871
Cdd:PRK13208 786 ELVEGDPELEV 796
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
2-994 |
3.74e-137 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 443.64 E-value: 3.74e-137
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 2 DDLSDQYTPADIESVVGDYWDEENAYEATKEAHADDPAFFFVDGPPYTSGQMHLGTAWNKTLKDAIIRYKRMTGHRVTDR 81
Cdd:PTZ00427 66 TGVSENPNIVEEEEKVLKYWKSIDAFNTSNKLAKNKKAYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERK 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 82 PGYDMHGLPIEVKVEEELGFETKRDIEEYGMESFIDECKSFAERNREAMDDDFQSIGVWMDWDDPYKTLSPEYMEAAWWA 161
Cdd:PTZ00427 146 FGWDCHGLPIEYEIEKENNINKKEDILKMGIDVYNEKCRGIVLKYSNEWVKTVERIGRWIDFKNDYKTMDKTFMESVWWV 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 162 FDQVADRGLVERGKRSVNYCPRCQTAIAANEVE--YDEIDSPSIYVKFPL-----------------------------E 210
Cdd:PTZ00427 226 FSELYKNNYVYKSFKVMPYSCKCNTPISNFELNlnYKDTPDPSIIISFVLcsdfpkveeecnieedkqllgekysvlynN 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 211 DREGSL------------------VIWTTTPWTIPANTFVAVDGEMTYqaVRAEKGGESEVLYLAEPCVEDVLKKGRY-- 270
Cdd:PTZ00427 306 KRENSNngnnnstnnvcyaqhseiLAWTTTPWTLPSNLALCVNEHFTY--LRIHHVKSNRVVIVGECRLEWIMKELKWnv 383
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 271 EDYEVVEELSGEEMVGWEYdNPLAGHLNEYADF-EGAGEVYTAEYVEADR-TGLVHSAPGHGQEDFARGQDLGL-----D 343
Cdd:PTZ00427 384 EDLKIVNRFKGKELKGLRY-KPLFTNFYEKYNFkERAYKILADDFVTDDAgTGIVHCAPTYGEDDFRVCKKNGVidpekN 462
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 344 VFV-PVDGRGEFTEQAGDYAGTFVRDANPDIIEDLEADGSLLHSGEHSHRYGHCWRCDTDIIFLATDQWFITVTDVKDEL 422
Cdd:PTZ00427 463 IFIdPLDANGYFTNEVEEVQNLYIKEADNVIKKKLKNENRLLSNNTIVHSYPFCWRSDTPLIYRAIPAWFIRVSNSTNEL 542
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 423 LDNIEDSEWHPQWARDNRFRDFVADAPDWNISRQRYWGIPLPIWESEDGEDFIVVGTREELAERAD-QDVDpgelDLHRP 501
Cdd:PTZ00427 543 VKNNETTYWIPAHIKEKKFHNWIKDAKDWCISRNRYWGTPIPIWADEKMETVICVESIKHLEELSGvKNIN----DLHRH 618
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 502 SVDPLTITE-DGTTY---ERVPDVFDVWIDSSVATWGTLDYP--GNETDFEELWPADLIVEAHDQTRGWFWSQLGMGTAA 575
Cdd:PTZ00427 619 FIDHIEIKNpKGKTYpklKRIPEVFDCWFESGSMPYAKVHYPfsTEKEDFHKIFPADFIAEGLDQTRGWFYTLLVISTLL 698
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 576 RGEIPYEEVLMHGFANDENGRKMSKSLGNIVTPEEAIDRAGRDPLRAYLL-SHDQQGVDLSFDWDGLAD-TQSALNIFWN 653
Cdd:PTZ00427 699 FDKAPFKNLICNGLVLASDGKKMSKRLKNYPDPLYILDKYGADSLRLYLInSVAVRAENLKFQEKGVNEvVKSFILPFYH 778
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 654 VFRFplPYMELDGYDPANP-------DLSAGELSVVDEWVLSRLQTVKADVADAWDDYEVHDALNAILDFVtEDVSRFYV 726
Cdd:PTZ00427 779 SFRF--FSQEVTRYECLNKkqflfntDYIYKNDNIMDQWIFSSVQSLTKSVHTEMKAYKLYNVLPKLLQFI-ENLTNWYI 855
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 727 KAIRERMWEEEDSESKRGAYATLATVLNETVQLIAPFTPYVAERMYQ----------HLDGSETT--------------- 781
Cdd:PTZ00427 856 RLNRDRMRGSLGEENCLQSLCTTYRTLHLFTVLMAPFTPFITEYIYQqlrrvkstneHNENNETGntkegdlnrgvihks 935
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 782 VHALDYPTVDEAWR-DEELERNMAVLRNVEEAAANARQQGERKLRWPVQRVVVASEDDEVAEAVEALSDLLADRVNTRTI 860
Cdd:PTZ00427 936 VHFIMLPQVDEKYIiDYEIIELIEKMKDVILLGRVLRERRKVASKKPLKSITILHPNESYFKNFDQISNYIKEELNVLNV 1015
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 861 EVVETFDELVEYADPQMGVIGPAFGGDAQKVMQAVKGVPREEV-----ESGVEVDGETVELTDEMVEYRaeppeNVYDAE 935
Cdd:PTZ00427 1016 ECSNDTSCLDFSAIPNYKTLGVKLGYNLKKVQNKIKNMDSESIklyqqEGKITLDNVTLEGDDIIIQMK-----PNFQND 1090
|
1050 1060 1070 1080 1090
....*....|....*....|....*....|....*....|....*....|....*....
gi 492946146 936 FAATDGTDGGVVYVDTSLTEEIEAEGYARDVIRRIQEMRKRLSLDVEEEIAVSLDVQDD 994
Cdd:PTZ00427 1091 NTDIISNNYVTILMDFTTDQQLENMASARELCNHIQKMRKNLSLNQNSPVKMHVYIADD 1149
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
38-636 |
1.90e-123 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 380.42 E-value: 1.90e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 38 PAFFFVDGPPYTSGQMHLGTAWNKTLKDAIIRYKRMTGHRVTDRPGYDMHGLPIEVKVEEELGFETKRDIEEYGMESFID 117
Cdd:cd00818 1 PEFVFHDGPPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGKKDIEKMGIAEFNA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 118 ECKSFAERNREAMDDDFQSIGVWMDWDDPYKTLSPEYMEAAWWAFDQVADRGLVERGKRSVNYcprcqtaiaaneveyde 197
Cdd:cd00818 81 KCREFALRYVDEQEEQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW----------------- 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 198 idsPSIYvkfpledregslviWTTTPWtipantFVAVDGemtyqavraekggesevlylaepcvedvLKKgryedyEVVE 277
Cdd:cd00818 144 ---PLIY--------------RATPQW------FIRVTK----------------------------IKD------RLLE 166
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 278 ELSGEEMVgweydnplaghlneyadfegagevytaeyveadrtglvhsaPGHGQEDFargqdlgldvfvpvdgrgefteq 357
Cdd:cd00818 167 ANDKVNWI-----------------------------------------PEWVKNRF----------------------- 182
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 358 agdyaGTFVRDANpdiiedleadgsllhsgehshryghcwrcdtdiiflatdqwfitvtdvkdelldniedsewhpqwar 437
Cdd:cd00818 183 -----GNWLENRR------------------------------------------------------------------- 190
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 438 dnrfrdfvadapDWNISRQRYWGIPLPIWESEDGEDFIVVgtreelaeradqdvdpgeldlhrpsvdpltitedgttyeR 517
Cdd:cd00818 191 ------------DWCISRQRYWGTPIPVWYCEDCGEVLVR---------------------------------------R 219
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 518 VPDVFDVWIDSSVATWGTLDYPGNETDFEELWPADLIVEAHDQTRGWFWSQLGMGTAARGEIPYEEVLMHGFANDENGRK 597
Cdd:cd00818 220 VPDVLDVWFDSGSMPYAQLHYPFENEDFEELFPADFILEGSDQTRGWFYSLLLLSTALFGKAPYKNVIVHGFVLDEDGRK 299
|
570 580 590
....*....|....*....|....*....|....*....
gi 492946146 598 MSKSLGNIVTPEEAIDRAGRDPLRAYLLSHDQQGVDLSF 636
Cdd:cd00818 300 MSKSLGNYVDPQEVVDKYGADALRLWVASSDVYAEDLRF 338
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
2-865 |
9.44e-110 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 361.68 E-value: 9.44e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 2 DDLSDQYTPADIESVVGDYWDEENAYEATKEAhaddpafffvDGPPYT--------SGQMHLGTAWNKTLKDAIIRYKRM 73
Cdd:COG0525 1 MELPKTYDPKEVEAKWYQYWEENGYFKADPDS----------DKEPFTivipppnvTGSLHMGHALNNTLQDILIRYKRM 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 74 TGHRVTDRPGYDmH-GLPIEVKVEEELGFE--TKRDIeeyGMESFIDECKSFAERNREAMDDDFQSIGVWMDWDDPYKTL 150
Cdd:COG0525 71 QGYNTLWQPGTD-HaGIATQAVVERQLAEEgkSRHDL---GREKFLERVWEWKEESGGTITNQLRRLGASCDWSRERFTM 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 151 SPEYMEAAWWAFDQVADRGLVERGKRSVNYCPRCQTAIAANEVEYDEIDSPSIYVKFPLEDREGSLVIWTTTPWTIPANT 230
Cdd:COG0525 147 DEGLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEVEHEEVKGHLWHIRYPLADGSGYIVVATTRPETMLGDT 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 231 FVAVDgemtyqavraekggesevlylaePcvEDvlkkGRYEDYevveelsgeemVGWEYDNPLAGHL-----NEYADFE- 304
Cdd:COG0525 227 AVAVH-----------------------P--ED----ERYKHL-----------IGKTVILPLVGREipiiaDEYVDPEf 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 305 GagevytaeyveadrTGLVHSAPGHGQEDFARGQDLGLDVFVPVDGRGEFTEQAGDYAG--TFV-RDAnpdIIEDLEADG 381
Cdd:COG0525 267 G--------------TGAVKITPAHDPNDFEVGKRHNLPMINILDEDGTINENAGKYRGldRFEaRKA---IVADLEELG 329
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 382 SLLHSGEHSHRYGHCWRCDTDIIFLATDQWFITVTDVKDELLDNIEDSE--WHP-QWArdNRFRDFVADAPDWNISRQRY 458
Cdd:COG0525 330 LLVKVEPHKHSVGHSDRSGTVIEPYLSDQWFVKMKPLAKPAIEAVEDGEikFVPeRWE--KTYFHWMENIRDWCISRQLW 407
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 459 WGIPLPIWESEDGEdfIVVGTREELAeradqdvdpgeldlhRPSVDPLTITEDgttyervPDVFDVWIDSSVATWGTLDY 538
Cdd:COG0525 408 WGHRIPAWYCPDGE--VYVARTEPEA---------------CAKAGSVNLTQD-------EDVLDTWFSSALWPFSTLGW 463
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 539 PGNETDFEELWPADLIVEAHDqtrgwFWsq--lgMGTAARGEIPYEEVLMHGFANDENGRKMSKSLGNIVTPEEAIDRAG 616
Cdd:COG0525 464 PEKTEDLKYFYPTSVLVTGFDii--fFWvarmimMGLHFTGEVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYG 541
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 617 RDPLRAYLLSHDQQGVDLSFDWDGLADTQSALNIFWNVFRFPLpyMELDGYDPaNPDLSAGELSVVDEWVLSRLQTVKAD 696
Cdd:COG0525 542 ADALRFTLAALASPGRDIKFDEERVEGYRNFANKLWNASRFVL--MNLEGFDP-GLDPDPEELSLADRWILSRLNKTIAE 618
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 697 VADAWDDYEVHDALNAILDFVTEDVSRFYVKAIRERMWeEEDSESKRGAYATLATVLNETVQLIAPFTPYVAERMYQHL- 775
Cdd:COG0525 619 VTEALEKYRFDEAAQALYDFVWNEFCDWYLELAKPRLY-GGDEAAKRETRATLVYVLEQILRLLHPFMPFITEEIWQKLp 697
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 776 --DGSETTVHAlDYPTVDEAWRDEELERNMAVLRNVEEAAANARqqGERKLRwPVQR--VVVASEDDEVAEAVEALSDLL 851
Cdd:COG0525 698 prKEGESIMLA-PWPEADEELIDEEAEAEFEWLKEVISAIRNIR--AEMNIP-PSKKlpLLLKGADEADRARLEENAAYI 773
|
890
....*....|....
gi 492946146 852 ADRVNTRTIEVVET 865
Cdd:COG0525 774 KRLARLEEITILVD 787
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
1-868 |
1.95e-108 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 358.26 E-value: 1.95e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 1 MDDLSDQYTPADIESVVGDYWDEENAYeatkeaHADDPafffvDGPPYT--------SGQMHLGTAWNKTLKDAIIRYKR 72
Cdd:PRK05729 2 MMELPKTYDPKEVEAKWYQKWEEKGYF------KPDDN-----SKKPFSivipppnvTGSLHMGHALNNTLQDILIRYKR 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 73 MTGHRVTDRPGYDMHGLPIEVKVEEELGFE--TKRDIeeyGMESFIDECKSFAERNREAMDDDFQSIGVWMDWDDPYKTL 150
Cdd:PRK05729 71 MQGYNTLWLPGTDHAGIATQMVVERQLAAEgkSRHDL---GREKFLEKVWEWKEESGGTITNQLRRLGASCDWSRERFTM 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 151 SPEYMEAAWWAFDQVADRGLVERGKRSVNYCPRCQTAIAANEVEYDEIDSPSIYVKFPLEDREGSLVIWTTTPWTIPANT 230
Cdd:PRK05729 148 DEGLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEVEYKEVKGKLWHIRYPLADGSDYLVVATTRPETMLGDT 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 231 FVAVDgemtyqavraekggesevlylaePcvEDvlkkGRYEDyevveelsgeeMVGWEYDNPLAGHL-----NEYADFE- 304
Cdd:PRK05729 228 AVAVN-----------------------P--ED----ERYKH-----------LIGKTVILPLVGREipiiaDEYVDPEf 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 305 GagevytaeyveadrTGLVHSAPGHGQEDFARGQDLGLDVFVPVDGRGEFTEQAGDYAGTFVRDANPDIIEDLEADGSLL 384
Cdd:PRK05729 268 G--------------TGAVKITPAHDPNDFEVGKRHNLPMINIMDEDGTINENPGEYQGLDRFEARKAIVADLEELGLLV 333
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 385 HSGEHSHRYGHCWRCDTDIIFLATDQWFITVTDVKDELLDNIEDSE--WHP-QWarDNRFRDFVADAPDWNISRQRYWGI 461
Cdd:PRK05729 334 KIEPHTHSVGHSDRSGVVIEPYLSDQWFVKMKPLAKPALEAVENGEikFVPeRW--EKTYFHWMENIQDWCISRQLWWGH 411
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 462 PLPIWESEDGEdfIVVGTREELAeradqdvdPGELDLHRpsvdpltiteDgttyervPDVFDVWIDSSVATWGTLDYPGN 541
Cdd:PRK05729 412 RIPAWYDEDGE--VYVGREEPEA--------REKALLTQ----------D-------EDVLDTWFSSALWPFSTLGWPEK 464
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 542 ETDFEELWPADLIVEAHDQTrgWFWsq--lgMGTAARGEIPYEEVLMHGFANDENGRKMSKSLGNIVTPEEAIDRAGRDP 619
Cdd:PRK05729 465 TEDLKRFYPTSVLVTGFDII--FFWvarmimMGLHFTGQVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADA 542
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 620 LRAYLLSHDQQGVDLSFDWDGLADTQSALNIFWNVFRFPLpyMELDGYDPANPDLSAgELSVVDEWVLSRLQTVKADVAD 699
Cdd:PRK05729 543 LRFTLAALASPGRDIRFDEERVEGYRNFANKLWNASRFVL--MNLEGADVGELPDPE-ELSLADRWILSRLNRTVAEVTE 619
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 700 AWDDYEVHDALNAILDFVTEDVSRFYVKAIRERMWEEEdsesKRGAYATLATVLNETVQLIAPFTPYVAERMYQHL---D 776
Cdd:PRK05729 620 ALDKYRFDEAARALYEFIWNEFCDWYLELAKPVLQEAA----KRATRATLAYVLEQILRLLHPFMPFITEELWQKLaplG 695
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 777 GSETTVHAlDYPTVDEAWrDEELERNMAVLRNVEEAAANARqqGERKLRwPVQR--VVVASEDDEVAEAVEALSDLLADR 854
Cdd:PRK05729 696 IEESIMLA-PWPEADEAI-DEAAEAEFEWLKELITAIRNIR--AEMNIP-PSKKlpLLLKGADAEDRARLEANEAYIKRL 770
|
890
....*....|....
gi 492946146 855 VNTRTIEVVETFDE 868
Cdd:PRK05729 771 ARLESLEILADDEE 784
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
3-846 |
1.00e-100 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 341.20 E-value: 1.00e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 3 DLSDQYTPADIESVVGDYWDEENAYEAtKEAHADDPAFFFVDGPPYTSGQMHLGTAWNKTLKDAIIRYKRMTGHRVTDRP 82
Cdd:PRK14900 14 ELAKGYEHREVEARWYPFWQERGYFHG-DEHDRTRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLP 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 83 GYDMHGLPIEVKVEEELGFETKRDIEEYGMESFIDECKSFAERNREAMDDDFQSIGVWMDWDDPYKTLSPEYMEAAWWAF 162
Cdd:PRK14900 93 GTDHAGIATQMIVEKELKKTEKKSRHDLGREAFLERVWAWKEQYGSRIGEQHKALGASLDWQRERFTMDEGLSRAVREVF 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 163 DQVADRGLVERGKRSVNYCPRCQTAIAANEVEYDEIDSPSIY-VKFPLEDREGSLVIWTTTPWTIPANTFVAVDGE-MTY 240
Cdd:PRK14900 173 VRLHEEGLIYREKKLINWCPDCRTALSDLEVEHEEAHQGELWsFAYPLADGSGEIVVATTRPETMLGDTAVAVHPLdPRY 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 241 QAVRAEKggesevlylaepcvedvlkkgryedyeVVEELSGEEMvgweydnPLaghlneyadfegageVYTAEYVEAD-R 319
Cdd:PRK14900 253 MALHGKK---------------------------VRHPITGRTF-------PI---------------VADAILVDPKfG 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 320 TGLVHSAPGHGQEDFARGQDLGLDVFVPVDGRGEFTEQAGDYAGTFVRDANPDIIEDLEADGSLLHSGEHSHRYGHCWRC 399
Cdd:PRK14900 284 TGAVKVTPAHDFNDFEVGKRHGLEMITVIGPDGRMTAEAGPLAGLDRFEARKEVKRLLAEQGLDRGAKPHVLPLGRCQRS 363
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 400 DTDIIFLATDQWFITVTDVKDELLDNIED--SEWHP-QWArdNRFRDFVADAPDWNISRQRYWGIPLPIWESEDGEdfiV 476
Cdd:PRK14900 364 ATILEPLLSDQWYVRIEPLARPAIEAVEQgrTRFIPeQWT--NTYMAWMRNIHDWCISRQLWWGHQIPAWYCPDGH---V 438
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 477 VGTREElaeradqdvdpgeldlhrPSVDPltiTEDGTTYERVPDVFDVWIDSSVATWGTLDYPGNETDFEELWPADLIVE 556
Cdd:PRK14900 439 TVARET------------------PEACS---TCGKAELRQDEDVLDTWFSSGLWPFSTMGWPEQTDTLRTFYPTSVMET 497
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 557 AHDQTRGWFWSQLGMGTAARGEIPYEEVLMHGFANDENGRKMSKSLGNIVTPEEAIDRAGRDPLRAYLLSHDQQGVDLSF 636
Cdd:PRK14900 498 GHDIIFFWVARMMMMGLHFMGEVPFRTVYLHPMVRDEKGQKMSKTKGNVIDPLVITEQYGADALRFTLAALTAQGRDIKL 577
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 637 DWDGLADTQSALNIFWNVFRFPLpyMELDGYDPANPDLSAGELSVVDEWVLSRLQTVKADVADAWDDYEVHDALNAILDF 716
Cdd:PRK14900 578 AKERIEGYRAFANKLWNASRFAL--MNLSGYQERGEDPARLARTPADRWILARLQRAVNETVEALEAFRFNDAANAVYAF 655
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 717 VTEDVSRFYVKAIRERMWeEEDSESKRGAYATLATVLNETVQLIAPFTPYVAERMYQHL------DGSETTVHALDYPTV 790
Cdd:PRK14900 656 VWHELCDWYIELAKEALA-SEDPEARRSVQAVLVHCLQTSYRLLHPFMPFITEELWHVLraqvgaSAWADSVLAAEYPRK 734
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 492946146 791 DEAwrDEELERNMAVLRNVEEAAANARqqGERKLRWPVQ-----RVVVASEDDEVAEAVEA 846
Cdd:PRK14900 735 GEA--DEAAEAAFRPVLGIIDAVRNIR--GEMGIPWKVKlgaqaPVEIAVADPALRDLLQA 791
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
4-809 |
7.85e-85 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 295.76 E-value: 7.85e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 4 LSDQYTPADIESVVGDYWDEENAY---EATKEAHADDPaFFFVDGPPYTSGQMHLGTAWNKTLKDAIIRYKRMTGHRVTD 80
Cdd:PTZ00419 24 MAASYDPKEVESGWYEWWEKSGFFkpaEDAKSLNSGKK-FVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLW 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 81 RPGYDMHGLPIEVKVEEELGFETKRDIEEYGMESFIDECKSFAERNREAMDDDFQSIGVWMDWDDPYKTLSPEYMEAAWW 160
Cdd:PTZ00419 103 VPGTDHAGIATQVVVEKKLMKEENKTRHDLGREEFLKKVWEWKDKHGNNICNQLRRLGSSLDWSREVFTMDEQRSKAVKE 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 161 AFDQVADRGLVERGKRSVNYCPRCQTAIAANEVEYDEIDSPS----------------IYVKFPLEDR-EGSLVIWTTTP 223
Cdd:PTZ00419 183 AFVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVEFEEIEKPTkitipgydkkvevgvlWHFAYPLEDSgQEEIVVATTRI 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 224 WTIPANTFVAVDgemtyqavraekggesevlylaePcvedvlKKGRYEDYevveelsgeemVGWEYDNPLAGH--LNEYA 301
Cdd:PTZ00419 263 ETMLGDVAVAVH-----------------------P------KDERYKKL-----------HGKELIHPFIPDrkIPIIA 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 302 DfegagevytAEYVEAD-RTGLVHSAPGHGQEDFARGQDLGLDVFVPVDGRGEFTEQAGDYAGTFVRDANPDIIEDLEAD 380
Cdd:PTZ00419 303 D---------DELVDMEfGTGAVKITPAHDPNDYEIAKRHNLPFINIFTLDGKINENGGEFAGMHRFDCRRKIEEELKEM 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 381 GSLLHSGEHSHRYGHCWRCDtDII-FLATDQWFITVTDVKDELLDNIEDSEW--HPQWARDNRFRdFVADAPDWNISRQR 457
Cdd:PTZ00419 374 GLLRDKVPNPMRLPRCSRSG-DIVePMLIPQWYVNCKDMAKRAVEAVRNGELkiIPSSHENVWYH-WLENIQDWCISRQL 451
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 458 YWGIPLP--------IWESEDGEDFIVVGTREELA-ERADQDVDpgeldlhrpsvdpltITEDGTTYERVPDVFDVWIDS 528
Cdd:PTZ00419 452 WWGHRIPayrviskgPETDPSDEEPWVVARSEEEAlEKAKKKFG---------------LSEEDFELEQDEDVLDTWFSS 516
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 529 SVATWGTLDYPGNETDFEELWPADLIVEAHDQTRGWFWSQLGMGTAARGEIPYEEVLMHGFANDENGRKMSKSLGNIVTP 608
Cdd:PTZ00419 517 GLFPFSTLGWPDQTDDLQRFFPTSLLETGSDILFFWVARMVMMSLHLTDKLPFKTVFLHAMVRDSQGEKMSKSKGNVIDP 596
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 609 EEAID----------------------RA---------------GRDPLRAYLLSHDQQGVDLSFDWDGLADTQSALNIF 651
Cdd:PTZ00419 597 LEVIEgislqdlnqklyegnlpekeikRAielqkkefpngipecGTDALRFGLLAYTQQGRNINLDINRVVGYRHFCNKL 676
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 652 WNVFRFPLPYMELDGYDP---ANPDLSAGELSVVDEWVLSRLQTVKADVADAWDDYEVHDALNAILDFVTEDVSRFYVKA 728
Cdd:PTZ00419 677 WNAVKFALMKLLKDFNLPnstLFKPNNVESLPWEDKWILHRLNVAIKEVTEGFKEYDFSEATQATYNFWLYELCDVYLEL 756
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 729 IRERMWEEEDSESKRGAYATLATVLNETVQLIAPFTPYVAERMYQHLDGSETTVHAL---DYPTVDEAWRDEELERNMAV 805
Cdd:PTZ00419 757 IKPRLSKQSDGERKQHAQDVLHTVLDIGLRLLHPMMPFITEELYQRLPNYLRKSESIsiaKYPQPNPGWNNEALDEEMKI 836
|
....
gi 492946146 806 LRNV 809
Cdd:PTZ00419 837 IMSI 840
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
14-865 |
6.33e-73 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 261.03 E-value: 6.33e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 14 ESVVGDYWDEENAYEATKEAhADDPaFFFVDGPPYTSGQMHLGTAWNKTLKDAIIRYKRMTGHRVTDRPGYDMHGLPIEV 93
Cdd:PLN02943 66 EERIYNWWESQGYFKPNFDR-GGDP-FVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGIATQL 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 94 KVEEELGFE-TKRdiEEYGMESFIDECKSFAERNREAMDDDFQSIGVWMDWDDPYKTLSPEYMEAAWWAFDQVADRGLVE 172
Cdd:PLN02943 144 VVEKMLASEgIKR--TDLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGLIY 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 173 RGKRSVNYCPRCQTAIAANEVEYDEIDSPSIYVKFPLE-DREGSLVIWTTTPWTIPANTFVAVDGEmtyqavraekgges 251
Cdd:PLN02943 222 QGSYMVNWSPNLQTAVSDLEVEYSEEPGTLYYIKYRVAgGSEDFLTIATTRPETLFGDVAIAVNPE-------------- 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 252 evlylaepcvedvlkKGRYEDYevveelsgeemVGWEYDNPLAG--HLNEYADfegagevytaEYVEAD-RTGLVHSAPG 328
Cdd:PLN02943 288 ---------------DDRYSKY-----------IGKMAIVPMTYgrHVPIIAD----------RYVDKDfGTGVLKISPG 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 329 HGQEDFARGQDLGLDVFVPVDGRGEFTEQAGDYAgtfvRDANPDIIEDLEADGSLLHSGEHSHRYGHCWRCDTDIIFLAT 408
Cdd:PLN02943 332 HDHNDYLLARKLGLPILNVMNKDGTLNEVAGLYW----FEAREKLWSDLEETGLAVKKEPHTLRVPRSQRGGEVIEPLVS 407
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 409 DQWFITVTDVKDELLDNIEDSEWHPQWARDNRFRDF-VADAPDWNISRQRYWGIPLPIWE---SEDGEDFIVVGTREELA 484
Cdd:PLN02943 408 KQWFVTMEPLAEKALKAVENGELTIIPERFEKIYNHwLSNIKDWCISRQLWWGHRIPVWYivgKDCEEDYIVARSAEEAL 487
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 485 ERAdqdvdpgeLDLHRPSVDpltITEDgttyervPDVFDVWIDSSVATWGTLDYPGNET-DFEELWPADLIVEAHDQTRG 563
Cdd:PLN02943 488 EKA--------REKYGKDVE---IYQD-------PDVLDTWFSSALWPFSTLGWPDVSAeDFKKFYPTTVLETGHDILFF 549
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 564 WFWSQLGMGTAARGEIPYEEVLMHGFANDENGRKMSKSLGNIVTPEEAIDRAGRDPLRaYLLSHDQQGVDLSFDWDGLAD 643
Cdd:PLN02943 550 WVARMVMMGIEFTGTVPFSYVYLHGLIRDSQGRKMSKTLGNVIDPLDTIKEFGTDALR-FTLALGTAGQDLNLSTERLTS 628
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 644 TQSALNIFWNVFRFPLPYMeldgydPANPDLSAGE---------------LSVVDEWVLSRLQTVKADVADAWDDYEVHD 708
Cdd:PLN02943 629 NKAFTNKLWNAGKFVLQNL------PSQSDTSAWEhilackfdkeesllsLPLPECWVVSKLHELIDSVTTSYDKYFFGD 702
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 709 ALNAILDFVTEDVSRFYVKAIRERMWEEEDSESKRGAYATLATVLNETVQLIAPFTPYVAERMYQHLDGSETTVHALDYP 788
Cdd:PLN02943 703 VGREIYDFFWSDFADWYIEASKTRLYHSGDNSALSRAQAVLLYVFENILKLLHPFMPFVTEELWQALPYRKEALIVSPWP 782
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 789 TVDEAwRDEELERNMAVLRNVEEAAANARQQGERKlrwPVQRV---VVASEddEVAEAVEALSDLLA--DRVNTRTIEVV 863
Cdd:PLN02943 783 QTSLP-KDLKSIKRFENLQSLTRAIRNARAEYSVE---PAKRIsasIVASA--EVIEYISKEKEVLAllSRLDLQNVHFT 856
|
..
gi 492946146 864 ET 865
Cdd:PLN02943 857 DS 858
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
46-636 |
2.68e-69 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 236.76 E-value: 2.68e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 46 PPYTSGQMHLGTAWNKTLKDAIIRYKRMTGHRVTDRPGYDMHGLPIEVKVEEELGFETKRDiEEYGMESFIDECKSFAER 125
Cdd:cd00817 9 PPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIEGKTR-HDLGREEFLEKCWEWKEE 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 126 NREAMDDDFQSIGVWMDWDDPYKTLSPEYMEAAWWAFDQVADRGLVERGKRsvnycprcqtaiaaneveydeidspsiyv 205
Cdd:cd00817 88 SGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNR----------------------------- 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 206 kfpledregsLVIWTTTpwtipANTFVAvdgemtyqavraekggesevlylaepcvedvlkkgryeDYEVveelsgeemv 285
Cdd:cd00817 139 ----------LVNWCPK-----LRTAIS--------------------------------------DIEV---------- 155
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 286 gweydnplaghlneyadfegagevytaeyveadrtglvhsapghgqedfargqdlgldvfvpvdgrgefteqagdyagtf 365
Cdd:cd00817 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 366 vrdanpdiiedleadgsllhsgehshryghCWRCDTDIIFLATDQWFITVTDVKDELLDNIEDSE--WHPQWARdNRFRD 443
Cdd:cd00817 156 ------------------------------CSRSGDVIEPLLKPQWFVKVKDLAKKALEAVKEGDikFVPERME-KRYEN 204
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 444 FVADAPDWNISRQRYWGIPLPIWESEDGEDFIVVGTREELAERADQDVDPGEldlhrpsvdpltiteDGTTYERVPDVFD 523
Cdd:cd00817 205 WLENIRDWCISRQLWWGHRIPAWYCKDGGHWVVAREEDEAIDKAAPEACVPC---------------GGEELKQDEDVLD 269
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 524 VWIDSSVATWGTLDYPGNETDFEELWPADLIVEAHDQTRGWFWSQLGMGTAARGEIPYEEVLMHGFANDENGRKMSKSLG 603
Cdd:cd00817 270 TWFSSSLWPFSTLGWPEETKDLKKFYPTSLLVTGHDIIFFWVARMIMRGLKLTGKLPFKEVYLHGLVRDEDGRKMSKSLG 349
|
570 580 590
....*....|....*....|....*....|...
gi 492946146 604 NIVTPEEAIDRAGRDPLRAYLLSHDQQGVDLSF 636
Cdd:cd00817 350 NVIDPLDVIDGYGADALRFTLASAATQGRDINL 382
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
636-814 |
6.25e-67 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 222.43 E-value: 6.25e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 636 FDWDGLADTQS-ALNIFWNVFRFPLPYMELDGYDPANPDLSAGELSVVDEWVLSRLQTVKADVADAWDDYEVHDALNAIL 714
Cdd:cd07961 1 FSEKGVREVVRkVLLPLWNAYRFFVTYANLDGFDPGKDDDAVASLNVLDRWILSRLNSLIKEVTEEMEAYDLYTAVRALL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 715 DFVTEDvSRFYVKAIRERMWEEEDSESKRGAYATLATVLNETVQLIAPFTPYVAERMYQHL----DGSETTVHALDYPTV 790
Cdd:cd07961 81 EFIDEL-TNWYIRRNRKRFWGEEGDDDKLAAYATLYEVLLTLSRLMAPFTPFITEEIYQNLrrelGDAPESVHLLDWPEV 159
|
170 180
....*....|....*....|....
gi 492946146 791 DEAWRDEELERNMAVLRNVEEAAA 814
Cdd:cd07961 160 DESLIDEELEEAMELVREIVELGR 183
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
4-865 |
1.66e-60 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 225.16 E-value: 1.66e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 4 LSDQYTPADIESVVGDYWDEENAYEAtkEAHADDPAFFFVDGPPYTSGQMHLGTAWNKTLKDAIIRYKRMTGHRVTDRPG 83
Cdd:PLN02381 96 MAKQYSPSAVEKSWYAWWEKSGYFGA--DAKSSKPPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPG 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 84 YDMHGLPIEVKVEEELGFETKRDIEEYGMESFIDECKSFAERNREAMDDDFQSIGVWMDWDDPYKTLSPEYMEAAWWAFD 163
Cdd:PLN02381 174 VDHAGIATQVVVEKKLMRERHLTRHDIGREEFVSEVWKWKDEYGGTILNQLRRLGASLDWSRECFTMDEQRSKAVTEAFV 253
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 164 QVADRGLVERGKRSVNYCPRCQTAIAANEVEYDEI-----------DSPS-----IYVKFPLEDREGSLVIWTTTPWTIP 227
Cdd:PLN02381 254 RLYKEGLIYRDIRLVNWDCTLRTAISDVEVDYIDIkertllkvpgyDKPVefgvlTSFAYPLEGGLGEIVVATTRIETML 333
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 228 ANTFVAVDGEmtyqavraekggesevlylaepcvedvlkKGRYEdyevveELSGEEMVgweydNPLAGH-LNEYADfega 306
Cdd:PLN02381 334 GDTAIAIHPD-----------------------------DERYK------HLHGKFAV-----HPFNGRkLPIICD---- 369
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 307 gevytAEYVEAD-RTGLVHSAPGHGQEDFARGQDLGLDVFVPVDGRGEFTEQAG-DYAGTFVRDANPDIIEDLEADGSLL 384
Cdd:PLN02381 370 -----AILVDPNfGTGAVKITPAHDPNDFEVGKRHNLEFINIFTDDGKINSNGGsEFAGMPRFAAREAVIEALQKKGLYR 444
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 385 HSGEHSHRYGHCWRCDTDIIFLATDQWFITVTDVKDELLDNIEDSE----------WHPQWARdnrfrdFVADAPDWNIS 454
Cdd:PLN02381 445 GAKNNEMRLGLCSRTNDVVEPMIKPQWFVNCSSMAKQALDAAIDGEnkklefipkqYLAEWKR------WLENIRDWCIS 518
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 455 RQRYWGIPLPIWES--EDGED---------FIVVGTREELAERADQDVDPGELDLHRPsvdpltitedgttyervPDVFD 523
Cdd:PLN02381 519 RQLWWGHRIPAWYVtlEDDQLkelgsyndhWVVARNESDALLEASQKFPGKKFELSQD-----------------PDVLD 581
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 524 VWIDSSVATWGTLDYPGNETDFEELWPADLIVEAHDQTRGWFWSQLGMGTAARGEIPYEEVLMHGFANDENGRKMSKSLG 603
Cdd:PLN02381 582 TWFSSGLFPLSVLGWPDDTDDLKAFYPTSVLETGHDILFFWVARMVMMGMQLGGDVPFRKVYLHPMIRDAHGRKMSKSLG 661
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 604 NIVTPEEAID-------------------------------------RAGRDPLRAYLLSHDQQGVDLSFDWDGLADTQS 646
Cdd:PLN02381 662 NVIDPLEVINgisleglhkrleegnldpkelvvakegqkkdfpngiaECGTDALRFALVSYTAQSDKINLDILRVVGYRQ 741
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 647 ALNIFWNVFRFPLPYMELDGYDPANPDLSAGELSVvdEWVLSRLQTVKADVADAWDDYEVHDALNAILDFVTEDVSRFYV 726
Cdd:PLN02381 742 WCNKLWNAVRFAMSKLGDDYTPPATLSVETMPFSC--KWILSVLNKAISKTVSSLDAYEFSDAASTVYSWWQYQFCDVFI 819
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 727 KAIRERMWEEEDS-ESKRG-AYATLATVLNETVQLIAPFTPYVAERMYQHLDGSETT-----VHALDYPTVDEAWRDEEL 799
Cdd:PLN02381 820 EAIKPYFAGDNPEfASERAaAQDTLWICLDTGLRLLHPFMPFVTEELWQRLPQPKDHtrkdsIMISEYPSAVEAWTNEKV 899
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 492946146 800 ERNM-AVLRNVE-----EAAANARQQGERKLRWPVqrvvvaSEDDEVAEAVEALSDLLADRVNTRTIEVVET 865
Cdd:PLN02381 900 EYEMdLVLSTVKclrslRAEVLEKQKNERLPAFAL------CRNQEIAAIIKSHQLEILTLANLSSLKVLLS 965
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
407-636 |
8.73e-47 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 170.29 E-value: 8.73e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 407 ATDQWFITVTDVKDELLDNIEDSEWHPQWARdNRFRDFVADAPDWNISRQRYWGIPLPiwesedgedfivvgtreelaer 486
Cdd:cd00668 138 ITEQWFFDMPKFKEKLLKALRRGKIVPEHVK-NRMEAWLESLLDWAISRQRYWGTPLP---------------------- 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 487 adqdvdpgeldlhrpsvdpltitedgttyervPDVFDVWIDSSVATWGTLDYPGNETDFEELWPADLIVEAHDQTRGWFW 566
Cdd:cd00668 195 --------------------------------EDVFDVWFDSGIGPLGSLGYPEEKEWFKDSYPADWHLIGKDILRGWAN 242
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 567 SQLGMGTAARGEIPYEEVLMHGFANDENGRKMSKSLGNIVTPEEAIDRAGRDPLRAYLLSHDQQGVDLSF 636
Cdd:cd00668 243 FWITMLVALFGEIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDVVEKYGADALRYYLTSLAPYGDDIRL 312
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
53-811 |
7.27e-44 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 172.36 E-value: 7.27e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 53 MHLGTAWNKTLKDAIIRYKRMTGHRV--------TDRPGY------------------DMHGLPievkvEEEL-GFETKR 105
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVlfpmafhvTGTPILgiaeriargdpetielykSLYGIP-----EEELeKFKDPE 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 106 DIEEYgmesfidecksFAERNREAMDddfqSIGVWMDWDDPYKTLSPEYMEAAWWAFDQVADRGLVERGKRSVNYCPRCQ 185
Cdd:PRK12300 76 YIVEY-----------FSEEAKEDMK----RIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDN 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 186 TAIAANEVEYDEidSPSI----YVKFPlEDREGSLVIWTTTPWTIPANTFVAVDGEMTYqaVRAEKGGESEVLylaepcV 261
Cdd:PRK12300 141 NPVGDHDLLDGE--EPEIveytLIKFE-ESEDLILPAATLRPETIFGVTNLWVNPDATY--VKAEVDGEKWIV------S 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 262 EDVLKKGRYEDYEV--VEELSGEEMVGWEYDNPLAGhlnEYAdfegagEVYTAEYVEADR-TGLVHSAPGHGQEDFARGQ 338
Cdd:PRK12300 210 KEAAEKLSFQDRDVeiIEEIKGSELIGKKVKNPVTG---KEV------PILPADFVDPDNgTGVVMSVPAHAPYDYVALR 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 339 DLG-----LDVFVP-----VDGRGEF------------------------------------TEQAGDYAGTFVRDANPD 372
Cdd:PRK12300 281 DLKknkelLDVIEPiplieVEGYGEFpakevveklgiksqedpeleeatkevyraefhkgvlKENTGEYAGKPVREAREK 360
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 373 IIEDLEADGSLLHSGEHSHRYGHCwRCDTDIIF-LATDQWFITVTDV--KDELLDNIEDSEWHPQWARDNrFRDFVADAP 449
Cdd:PRK12300 361 ITKDLIEKGIADIMYEFSNRPVYC-RCGTECVVkVVKDQWFIDYSDPewKELAHKALDNMEIIPEEYRKE-FENTIDWLK 438
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 450 DWNISRQRYWGIPLPiWEsedgEDFIVvgtrEELAER-------------ADQDVDPGELDlhrPSV---------DPLT 507
Cdd:PRK12300 439 DRACARRRGLGTRLP-WD----EEWII----ESLSDStiymayytiahkiREYGIKPEQLT---PEFfdyvflgkgDPEE 506
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 508 ITEDG----TTYERVPDVFDVWidssvatwgtldYP-----------GNETDF----------EELWPADLIVEahdqtr 562
Cdd:PRK12300 507 VSKKTgipkEILEEMREEFLYW------------YPvdwrhsgkdliPNHLTFfifnhvaifpEEKWPRGIVVN------ 568
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 563 gwfwsqlGMGTAargeipyeevlmhgfandeNGRKMSKSLGNIVTPEEAIDRAGRDPLRAYLLSHDQQGVDLSFDWDGLA 642
Cdd:PRK12300 569 -------GFVLL-------------------EGKKMSKSKGNVIPLRKAIEEYGADVVRLYLTSSAELLQDADWREKEVE 622
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 643 DTQSALNIFWNVFRfplpymELDGYDpanpdlSAGELSVVDEWVLSRLQTVKADVADAWDDYEVHDALNAILDFVTEDVs 722
Cdd:PRK12300 623 SVRRQLERFYELAK------ELIEIG------GEEELRFIDKWLLSRLNRIIKETTEAMESFQTRDAVQEAFYELLNDL- 689
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 723 RFYvkairERMWEEEDSEskrgayaTLATVLNETVQLIAPFTPYVAERMYqHLDGSETTVHALDYPTVDEAWRDEELERN 802
Cdd:PRK12300 690 RWY-----LRRVGEANNK-------VLREVLEIWIRLLAPFTPHLAEELW-HKLGGEGFVSLEKWPEPDESKIDEEAELA 756
|
....*....
gi 492946146 803 MAVLRNVEE 811
Cdd:PRK12300 757 EEYVKRLIE 765
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
5-845 |
9.26e-41 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 162.14 E-value: 9.26e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 5 SDQYTPADIESVVGDYWDEENAYEATKEAhaDDPAFFFVDGPPYTSGQMHLGTAWNKTLKDAIIRYKRMTGHRVTdRP-G 83
Cdd:COG0495 2 QERYNPKEIEKKWQKYWEENGTFKADEDS--SKPKYYVLDMFPYPSGRLHMGHVRNYTIGDVVARYKRMQGYNVL-HPmG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 84 YDMHGLPIEvkveeelgfetkrdieEYGMESFIDEcKSFAERNREAMDDDFQSIGVWMDWDDPYKTLSPEYMEaaW--WA 161
Cdd:COG0495 79 WDAFGLPAE----------------NAAIKNGVHP-AEWTYENIANMRRQLKRLGLSYDWSREIATCDPEYYK--WtqWI 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 162 FDQVADRGLVERGKRSVNYCPRCQTAIAaNE-------------VE-------------Y--------DEID-------- 199
Cdd:COG0495 140 FLQLYEKGLAYRKEAPVNWCPVDQTVLA-NEqvidgrcwrcgapVEkkelpqwflkitdYadellddlDKLDgwpekvkt 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 200 --------SPSIYVKFPLEDREGSLVIWTTTPWTIPANTFVAV--DGEMTYQAVRAEKggESEVL-YLAEpC-------- 260
Cdd:COG0495 219 mqrnwigrSEGAEVDFPVEGSDEKITVFTTRPDTLFGATFMVLapEHPLVKELATPEQ--NAAVAaFIEE-Akkkseier 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 261 -VEDVLKKG----RYedyeVVEELSGEEMvgweydnplaghlneyadfegagEVYTAEYVEADR-TGLVHSAPGHGQED- 333
Cdd:COG0495 296 tSETKEKTGvftgLY----AINPLTGEKI-----------------------PIWIADYVLMDYgTGAVMAVPAHDQRDf 348
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 334 -FARGQDLGL-DVFVPVDG-RGEFTEQA----------GDYAGTFVRDANPDIIEDLEADGSllhsGEhshryghcwrcd 400
Cdd:COG0495 349 eFAKKYGLPIkQVIAPEDGdDPDILEEAytgdgvlinsGEFDGLDSEEAKEAIIEWLEEKGL----GK------------ 412
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 401 tdiiflATDQWfitvtdvkdelldniedsewhpqwardnRFRDfvadapdWNISRQRYWGIPLPIWESEDGEdfiVVGTR 480
Cdd:COG0495 413 ------RKVNY----------------------------RLRD-------WLISRQRYWGEPIPIIHCEDCG---VVPVP 448
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 481 EE-----LAEraDQDVDPgeldlhrPSVDPL---------TITEDGTTYERVPDVFDVWIDSSvatWGTLDY--PGNET- 543
Cdd:COG0495 449 EDqlpveLPE--DVDFDP-------TGGSPLarapewvnvTCPKCGGPARRETDTMDTFVDSS---WYYLRYtdPHNDEa 516
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 544 --DFEEL--W-PADL-I--VE--------AhdqtRgwFWSQ----LGMgtaargeIPYEE----------VLMHGFANDE 593
Cdd:COG0495 517 pfDPEAAnyWlPVDQyIggIEhailhllyA----R--FFTKvlrdLGL-------VSFDEpfkrlltqgmVLEVGKDGVV 583
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 594 NGR--KMSKSLGNIVTPEEAIDRAGRDPLRAYLLShdqQG-VDLSFDWD--GLADTQSALNIFWNVFrfplpYMELDGYD 668
Cdd:COG0495 584 IGGieKMSKSKGNVVDPDEIIEKYGADTLRLFEMF---AGpPERDLEWSdsGVEGAYRFLNRVWRLV-----VDEAEALK 655
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 669 PANPDLSAGELSvvdewvLSRL--QTVKAdvadawddyevhdalnaildfVTEDVSRF-----------YVKAIRErmwE 735
Cdd:COG0495 656 LDVADLSEADKE------LRRAlhKTIKK---------------------VTEDIERLrfntaiaalmeLVNALYK---A 705
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 736 EEDSESKRGAYATLATVLnetVQLIAPFTPYVAERMYQHLdGSETTVHALDYPTVDEAW-RDEELErnMAV-----LRNV 809
Cdd:COG0495 706 KDSGEADRAVLREALETL---VLLLAPFAPHIAEELWERL-GHEGSVADAPWPEADEAAlVEDEVT--IVVqvngkVRGK 779
|
970 980 990
....*....|....*....|....*....|....*.
gi 492946146 810 EEAAANARQQGERKLrwpvqrvvvASEDDEVAEAVE 845
Cdd:COG0495 780 IEVPADASKEELEAA---------ALADEKVQKFLE 806
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
40-178 |
1.14e-36 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 141.02 E-value: 1.14e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 40 FFFVDGPPYTSGQMHLGTAWNKTLKDAIIRYKRMTGHRVTDRPGYDMHGLPIEVKVEEELGFETKRDIeeygMESFIDEC 119
Cdd:cd00668 2 FYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGGRKKKTIW----IEEFREDP 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 492946146 120 KSFAERNREAMDDDFQSIGVWMDWDDPYKTLSPEYMEAAWWAFDQVADRGLVERGKRSV 178
Cdd:cd00668 78 KEFVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTHPV 136
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
647-809 |
7.34e-32 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 122.63 E-value: 7.34e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 647 ALNIFWNVFRFPLPymELDGYDPANPDLSAGELSVVDEWVLSRLQTVKADVADAWDDYEVHDALNAILDFVTEDVSRFYV 726
Cdd:cd07960 12 AYRKIRNTFRFLLG--NLNDFDPAKDAVPYEELLELDRYALHRLNELIKEVREAYENYEFHKVYQALNNFCTVDLSAFYL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 727 KAIRERMW-EEEDSESKRGAYATLATVLNETVQLIAPFTPYVAERMYQHLDGS--ETTVHALDYPTVDEAWRDEELERNM 803
Cdd:cd07960 90 DIIKDRLYcDAKDSLERRSAQTVLYHILDALLKLLAPILPFTAEEVWEHLPGEkkEESVFLEDWPELPEEWKDEELEEKW 169
|
....*.
gi 492946146 804 AVLRNV 809
Cdd:cd07960 170 EKLLAL 175
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
683-832 |
1.87e-27 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 108.64 E-value: 1.87e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 683 DEWVLSRLQTVKADVADAWDDYEVHDALNAILDFVTEDVSRFYVKAIRERMWEEEDSESkrgAYATLATVLNETVQLIAP 762
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLSDWYLELIKDRLYGEEPDSR---AQTTLYEVLETLLRLLAP 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 763 FTPYVAERMYQHLdgsetTVHALDYPTVDEAWrDEELERNMAVLRNVEEAAANARQQGERKLRWPVQRVV 832
Cdd:pfam08264 78 FMPFITEELWQKE-----SIHLAPWPEDAELE-EAELEEAFELRQEIVQAIRKLRSELKIKKSLPLEVVI 141
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
652-775 |
1.07e-25 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 103.41 E-value: 1.07e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 652 WNVFRFPLPYMEldgyDPANPDLSAGELSVVDEWVLSRLQTVKADVADAWDDYEVHDALNAILDFVTEDVSRFYVKAIRE 731
Cdd:cd07962 17 WNAARFVLMNLE----DDDEPEEDPESLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEFFWNDFCDWYLELVKP 92
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 492946146 732 RMWeEEDSESKRGAYATLATVLNETVQLIAPFTPYVAERMYQHL 775
Cdd:cd07962 93 RLY-GEDEEEKKAARATLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
8-862 |
2.39e-25 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 113.38 E-value: 2.39e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 8 YTPADIESVVGDYWDEENAYEATKEAHADDPAFFFVDGPPYTSGQ-MHLGTAWNKTLKDAIIRYKRMTGHRVTDRPGYDM 86
Cdd:PLN02563 80 YPFHEIEPKWQRYWEENRTFRTPDDVDTSKPKFYVLDMFPYPSGAgLHVGHPEGYTATDILARYKRMQGYNVLHPMGWDA 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 87 HGLPIEvkveeelgfetkrdieEYGMESFIDEcKSFAERNREAMDDDFQSIGVWMDWDDPYKTLSPEYMEAAWWAFDQVA 166
Cdd:PLN02563 160 FGLPAE----------------QYAIETGTHP-KITTLKNIARFRSQLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLL 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 167 DRGLVERGKRSVNYCPRCQTAIAANEV-------------------------EY--------DEIDSP-SIY-------- 204
Cdd:PLN02563 223 KRGLAYQAEVPVNWCPALGTVLANEEVvdglsergghpvirkpmrqwmlkitAYadrlledlDDLDWPeSIKemqrnwig 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 205 ------VKFPLEDREGS-----LVIWTTTPWTIPANTFVAVDGE--MTYQAVRAEKGGEsevlylAEPCVEDVLKKGRYE 271
Cdd:PLN02563 303 rsegaeLDFSVLDGEGKerdekITVYTTRPDTLFGATYLVVAPEhpLLSSLTTAEQKEA------VEEYVDAASRKSDLE 376
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 272 DYEVVEELSGeEMVGWEYDNPLAGHlneyadfegAGEVYTAEYVEADR-TGLVHSAPGHGQEDFARGQDLGLD---VFVP 347
Cdd:PLN02563 377 RTELQKEKTG-VFTGSYAINPATGE---------AIPIWVADYVLGSYgTGAIMAVPAHDTRDFEFAQKFDLPikwVVKP 446
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 348 VDGRGEFTEQAgdYAGtfvrdanpdiiedleaDGSLLHSGEHShryghcwrcdTDIIFLATDQWFITVTdvkdelldnie 427
Cdd:PLN02563 447 ADGNEDDAEKA--YTG----------------EGVIVNSSSSG----------LDINGLSSKEAAKKVI----------- 487
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 428 dsewhpQWARDNRF--RDFVADAPDWNISRQRYWGIPLPIWESEDGEDFIVVGTRE---ELAERAD-QDVDPGELDLHR- 500
Cdd:PLN02563 488 ------EWLEETGNgkKKVNYKLRDWLFARQRYWGEPIPVVFLEDSGEPVPVPESDlplTLPELDDfTPTGTGEPPLAKa 561
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 501 ----PSVDPLtiteDGTTYERVPDVFDVWIDSsvaTWGTLDY--PGNET-----DFEELW-PADLIVEAHDQT-----RG 563
Cdd:PLN02563 562 vswvNTVDPS----SGKPARRETNTMPQWAGS---CWYYLRFmdPKNSNalvdkEKEKYWmPVDLYVGGAEHAvlhllYA 634
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 564 WFWSQL-------------------GM------GTAAR---GE-----------------IPYEEVLMHG----FANDEN 594
Cdd:PLN02563 635 RFWHKVlydigvvstkepfqclvnqGMilgeveYTAFKdsdGEyvsadtadrlgelqqekIPEEKVIKSGdsfvLKDDPS 714
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 595 GR------KMSKSLGNIVTPEEAIDRAGRDPLRAYLLSHDQQGVDLSFDWDGLADTQSALNIFWNVFrfplpymelDGyd 668
Cdd:PLN02563 715 IRliarahKMSKSRGNVVNPDDVVSEYGADSLRLYEMFMGPLRDSKTWSTSGVEGVHRFLGRTWRLV---------VG-- 783
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 669 PANPDLSAGELSVVDEWVLSRLQTvkadvadawddyevhDALNAILDFVTEDV--SRFYVkAIRERM--------WEEED 738
Cdd:PLN02563 784 APLPDGSFRDGTVVTDEEPSLEQL---------------RLLHKCIAKVTEEIesTRFNT-AISAMMeftnaaykWDKVP 847
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 739 SEskrgayatlatVLNETVQLIAPFTPYVAERMYQHLDGSETtvhaLDYPTVDEAwrDEELERNMAVLRNVeeaaanarq 818
Cdd:PLN02563 848 RE-----------AIEPFVLLLSPYAPHLAEELWFRLGHSNS----LAYEPWPEA--NPSYLVDDTVVLPV--------- 901
|
970 980 990 1000
....*....|....*....|....*....|....*....|....*.
gi 492946146 819 QGERKLRWPVQRVVVASEDDEVAEA--VEALSDLLADRVNTRTIEV 862
Cdd:PLN02563 902 QINGKTRGTIEVEEGCSEDDAFALAsqDEKLSKYLDGKEIKKRIYV 947
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
47-782 |
7.87e-25 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 110.20 E-value: 7.87e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 47 PYTSGQMHLGTAWNKTLKDAIIRYKRMTGHRV---TdrpGYDMHGLPIEVKVEEElgfetKRDIEEYgmesfidecksfA 123
Cdd:COG0143 10 PYANGPPHIGHLYTYIPADILARYQRLRGHDVlfvT---GTDEHGTKIELAAEKE-----GITPQEL------------V 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 124 ERNREAMDDDFQSIGVwmDWDDPYKTLSPEYMEAAWWAFDQVADRGLVERGKRSVNYCPRCQTaiaaneveydeidspsi 203
Cdd:COG0143 70 DRIHAEFKELFEKLGI--SFDNFIRTTSPEHKELVQEIFQRLYDNGDIYKGEYEGWYCPECER----------------- 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 204 yvkfpledregslviwtttpwtipantfvavdgemtyqavraekggesevlYLAEpcvedvlkkgRYEDyevveelsGEe 283
Cdd:COG0143 131 ---------------------------------------------------FLPD----------RYVE--------GT- 140
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 284 mvgweydnplaghlneyadfegagevytaeyveadrtglvhsAPGHGQEDfargqdlgldvfvpvdgrgefteQAGDyag 363
Cdd:COG0143 141 ------------------------------------------CPKCGAED-----------------------AYGD--- 152
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 364 tfvrdanpdiieDLEADGSLLHSGEHSHRYghCWRCDTDIIFLATDQWFITVTDVKDELLDNIEDsewHPQWaRDNRF-- 441
Cdd:COG0143 153 ------------QCENCGATLEPTELINPR--SAISGAPPELREEEHYFFRLSKYQDRLLEWIEE---NPDI-QPEVRne 214
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 442 -RDFVADA-PDWNISRQRYWGIPLPIWESedgedfivvgtreelaeradqdvdpgeldlHrpsvdpltitedgttyervp 519
Cdd:COG0143 215 vLSWLKEGlQDLSISRDFDWGIPVPGDPG------------------------------K-------------------- 244
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 520 dVFDVWID------SSVATWGtlDYPGNETDFEELWPADLIVEAH----DQTR--GWFW-SQLgMGTaarGEIPYEEVLM 586
Cdd:COG0143 245 -VFYVWFDaligyiSATKGYA--DDRGLPEDFEKYWPAPDTELVHfigkDIIRfhAIIWpAML-MAA---GLPLPKKVFA 317
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 587 HGFANDEnGRKMSKSLGNIVTPEEAIDRAGRDPLRAYLLSHDQQGVDLSFDWDGLAD-TQSAL-NIFWN--------VFR 656
Cdd:COG0143 318 HGFLTVE-GEKMSKSRGNVIDPDDLLDRYGPDALRYYLLREVPFGQDGDFSWEDFVArVNSDLaNDLGNlasrtlsmIHK 396
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 657 FplpymeLDGYDPAnpdlsAGELSVVDEWVLSRLQTVKADVADAWDDYEVHDALNAILDFVTEdVSRFyvkaIRERM-WE 735
Cdd:COG0143 397 Y------FDGKVPE-----PGELTEADEELLAEAEAALEEVAEAMEAFEFRKALEEIMALARA-ANKY----IDETApWK 460
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....
gi 492946146 736 EEDSESKrgayATLATVLNETVQ-------LIAPFTPYVAERMYQHLDGSETTV 782
Cdd:COG0143 461 LAKDEDP----ERLATVLYTLLEalrilaiLLKPFLPETAEKILEQLGLEGDEL 510
|
|
| DUF5915 |
pfam19302 |
Domain of unknown function (DUF5915); This presumed domain is found at the C-terminus of ... |
849-1040 |
1.73e-23 |
|
Domain of unknown function (DUF5915); This presumed domain is found at the C-terminus of isoleucyl tRNA ligase enzymes.
Pssm-ID: 437134 [Multi-domain] Cd Length: 195 Bit Score: 99.09 E-value: 1.73e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 849 DLLADRVNTRTIEVVETFDELVEY-ADPQMGVIGPAFGGDAQKVMQAVKGVPREEVES-------GVEVDGETVELTDEM 920
Cdd:pfam19302 2 DIIKEELNVKEVEFGADESELVEYsAKPNFPVLGKELGKLMKAAAKEIASLNQMEIQKildggtlTIDVDGEEIELTSED 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 921 VEYRAEPPENVYdaefAATDGTDGgvVYVDTSLTEEIEAEGYARDVIRRIQEMRKRLSLDVEEEIAVSLDVqDDRVADLV 1000
Cdd:pfam19302 82 LLVTRQGKEGLA----VANEGTLT--VALDTTITEELREEGLVREIVSKIQNLRKESGFEVTDRINLYVSG-NEMLEAAI 154
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 492946146 1001 YRHEDLIAEEVRATTLNSDGEDAdlTEEWDIEGVTVVISI 1040
Cdd:pfam19302 155 EKFEDYIKKETLAVEIIFNEEKE--YTEVDINGEKLKIAV 192
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
395-775 |
8.30e-19 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 91.10 E-value: 8.30e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 395 HCWRCDTDIIFLATDQWFITVTDVKDELLDNIEDsewHPQW----ARDNRFRDFVAD-APDWNISRQRY-WGIPLPiwes 468
Cdd:PRK11893 143 RCPPTGAPVEWVEEESYFFRLSKYQDKLLELYEA---NPDFiqpaSRRNEVISFVKSgLKDLSISRTNFdWGIPVP---- 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 469 edgedfivvgtreelaeradqdVDPGeldlHrpsvdpltitedgttyervpdVFDVWID---SSVATWG-TLDYPGNETD 544
Cdd:PRK11893 216 ----------------------GDPK----H---------------------VIYVWFDaltNYLTALGyPDDEELLAEL 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 545 FEELWPADLIVEAHDQTR----GWfwsqLGMGTAARGEIPyEEVLMHGFANDEnGRKMSKSLGNIVTPEEAIDRAGRDPL 620
Cdd:PRK11893 249 FNKYWPADVHLIGKDILRfhavYW----PAFLMAAGLPLP-KRVFAHGFLTLD-GEKMSKSLGNVIDPFDLVDEYGVDAV 322
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 621 RAYLLSHDQQGVDLSFDWDGLAD-TQSAL-----NIFWNVFRFPLPYmeLDGYDPanpdlSAGELSVVDEWVLSRLQTVK 694
Cdd:PRK11893 323 RYFLLREIPFGQDGDFSREAFINrINADLandlgNLAQRTLSMIAKN--FDGKVP-----EPGALTEADEALLEAAAALL 395
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 695 ADVADAWDDYEVHDALNAILDFVTEdvSRFYVKaiRERMWEEEDSESKRgayatLATVLN---ETVQLIA----PFTPYV 767
Cdd:PRK11893 396 ERVRAAMDNLAFDKALEAILALVRA--ANKYID--EQAPWSLAKTDPER-----LATVLYtllEVLRGIAvllqPVMPEL 466
|
....*...
gi 492946146 768 AERMYQHL 775
Cdd:PRK11893 467 AAKILDQL 474
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
41-181 |
2.94e-17 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 83.84 E-value: 2.94e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 41 FFVDGP-PYTSGQMHLGTAWNKTLKDAIIRYKRMTGHRVTDRPGYDMHGLPIEvkveeelGFETKRDIEEygmesfidec 119
Cdd:cd00812 2 FYILVMfPYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAE-------NAAIKIGRDP---------- 64
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 492946146 120 KSFAERNREAMDDDFQSIGVWMDWDDPYKTLSPEYMEAAWWAFDQVADRGLVERGKRSVNYC 181
Cdd:cd00812 65 EDWTEYNIKKMKEQLKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNWC 126
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
524-775 |
2.46e-16 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 83.70 E-value: 2.46e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 524 VWID--SSVATwgTLDYPGNETD-FEELWPADL------IVEAHdqtrGWFWSQLGMgtaARGEIPYEEVLMHGFANdEN 594
Cdd:PRK12267 227 VWIDalLNYIT--ALGYGSDDDElFKKFWPADVhlvgkdILRFH----AIYWPIMLM---ALGLPLPKKVFAHGWWL-MK 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 595 GRKMSKSLGNIVTPEEAIDRAGRDPLRAYLLSHDQQGVDLSFdwdgladTQSALnifwnVFRFplpymeldGYDPANpDL 674
Cdd:PRK12267 297 DGKMSKSKGNVVDPEELVDRYGLDALRYYLLREVPFGSDGDF-------SPEAL-----VERI--------NSDLAN-DL 355
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 675 --------------------SAGELSVVDEWVLSRLQTVKADVADAWDDYEVHDALNAILDFVtedvsRFYVKAIRERM- 733
Cdd:PRK12267 356 gnllnrtvaminkyfdgeipAPGNVTEFDEELIALAEETLKNYEELMEELQFSRALEEVWKLI-----SRANKYIDETAp 430
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 492946146 734 WEEEDSESKRGAYATLATVLNETVQ----LIAPFTPYVAERMYQHL 775
Cdd:PRK12267 431 WVLAKDEGKKERLATVMYHLAESLRkvavLLSPFMPETSKKIFEQL 476
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
395-641 |
5.45e-15 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 78.10 E-value: 5.45e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 395 HCWRCDTDIIFLATDQWFITVTDVKDELLDNIEDSEWHPQWARDNRFRDFVADA-PDWNISRQRYWGIPLPiweseDGED 473
Cdd:pfam09334 168 KCVICGTTPEVKETEHYFFDLSKFQDKLREWIEENNPEWPENVKNMVLEWLKEGlKDRAISRDLDWGIPVP-----GAEG 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 474 fivvgtreelaeradqdvdpgeldlhrpsvdpltitedgttyervpDVFDVWID------SSVATWGtldypGNETDFEE 547
Cdd:pfam09334 243 ----------------------------------------------KVFYVWLDapigyiSATKELS-----GNEEKWKE 271
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 548 LWPADLIVEAH-----DQTR--GWFWSQLGMGTaarGEIPYEEVLMHGFANDEnGRKMSKSLGNIVTPEEAIDRAGRDPL 620
Cdd:pfam09334 272 WWPNDPDTELVhfigkDIIYfhTIFWPAMLLGA---GYRLPTTVFAHGYLTYE-GGKMSKSRGNVVWPSEALDRFPPDAL 347
|
250 260
....*....|....*....|.
gi 492946146 621 RAYLLSHDQQGVDLSFDWDGL 641
Cdd:pfam09334 348 RYYLARNRPETKDTDFSWEDF 368
|
|
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
8-793 |
1.44e-14 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 78.64 E-value: 1.44e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 8 YTPADIESVVGDYWDEENAYEATKEAhaDDPAFFFVDGPPYTSGQMHLGTAWNKTLKDAIIRYKRMTGHRVTDRPGYDMH 87
Cdd:TIGR00396 1 YNHIEIEEKWQQKWDENKTFKVTDDS--SKPKYYILSMFPYPSGALHMGHVRNYTITDVLSRYYRMKGYNVLHPIGWDAF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 88 GLPIEvkveeelgfetkrdieEYGMESFIDEcKSFAERNREAMDDDFQSIGVWMDWDDPYKTLSPEYMEAAWWAFDQVAD 167
Cdd:TIGR00396 79 GLPAE----------------NAAIKRGIHP-AKWTYENIANMKKQLQALGFSYDWDREIATCDPEYYKWTQWIFLELFE 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 168 RGLVERGKRSVNYCPRCQTaiaaneveydeidspsiyvkfpledregslviwtttpwtipantfvavdgemtyqavraek 247
Cdd:TIGR00396 142 KGLAYVKEADVNWCPNDGT------------------------------------------------------------- 160
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 248 ggesevlylaepcvedVLkkgryedyevveelsgeemvgweydnplaghlneyadfegagevytaeyveadrtglvhsap 327
Cdd:TIGR00396 161 ----------------VL-------------------------------------------------------------- 162
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 328 ghgqedfargqdlgldvfvpvdgrgefteqagdyagtfvrdANPDIIEDleadgsllhsgehshryGHCWRCDTDIIFLA 407
Cdd:TIGR00396 163 -----------------------------------------ANEQVDSD-----------------GRSWRGDTPVEKKE 184
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 408 TDQWFITVTDVKDELLDNIEDSE-WH------------------------------------------------------ 432
Cdd:TIGR00396 185 LKQWFLKITAYAEELLNDLEELDhWPesvkemqrnwigksegveitfkiadhdekitvfttrpdtifgvtylalapehpl 264
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 433 ---------------------------------------------------PQWA---------------------RDNR 440
Cdd:TIGR00396 265 vekaaennpkvaafikkilnktvaertkatkekkgvdtgikaihpltgekiPIWVanyvlmeygtgavmgvpahdeRDFE 344
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 441 F-RDF------VADAP-----------------------------------------------------DWNISRQRYWG 460
Cdd:TIGR00396 345 FaQKYglpikpVIDPAekdlsltaaytedgvlvnsgefnglnssearnaiidmlekegkgkrkvnyrlrDWGFSRQRYWG 424
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 461 IPLPIWESEDGEdfIVVGTREELAERADQDVdpgELDLHRPSvdPLT-------ITEDGTTY--ERVPDVFDVWIDSSva 531
Cdd:TIGR00396 425 EPIPIIHCEDGG--VVPVPEEDLPVILPEDV---VYDGDGGS--PLSripewvnVTCPSCGKpaLRETDTMDTFAGSS-- 495
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 532 tWGTLDY--PGNETDFE-----ELW-PADLIVEAHDQT-------RgwFWSQL-------------------GMGTAAR- 576
Cdd:TIGR00396 496 -WYYLRYldPKNTDGPFdkekaEYWlPVDLYIGGIEHAilhllyaR--FFHKFlrdigyvntkepfkklinqGMVLGFYy 572
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 577 ---GEIPYEEVLM--HGFANDENGR-------KMSKSLGNIVTPEEAIDRAGRDPLRAYLLSHDQQGVDLSFDWDGLADT 644
Cdd:TIGR00396 573 ppnGKVPADVLTErdEKGKDKAGGElvyvgyeKMSKSKGNGIDPQEIVESYGADALRLFIMFMGPIAASLEWNESGLEGA 652
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 645 QSALNIFWNVFRFPLPymeldgyDPANPDLSAGELSVVDEWVLSRLQTVKADVAdawDDYEVHDALNAILDFVTEDVSRF 724
Cdd:TIGR00396 653 RRFLDRVWNLVYEITG-------ELDAASLTVTALEEAQKELRRDVHKFLKKVT---EDLEKRESFNTAISAMMELLNKL 722
|
970 980 990 1000 1010 1020
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 492946146 725 YvKAIRERMWEEedseskrgAYATLATVLNetvqliaPFTPYVAERMYQHLDGSETTVHALDYPTVDEA 793
Cdd:TIGR00396 723 Y-KAKKEALMLE--------YLKGFVTVLS-------PFAPHLAEELWEKLGSEPFIIDNAKWPVVDET 775
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
397-636 |
9.18e-13 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 70.64 E-value: 9.18e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 397 WRCDTDIIFLA----TDQWFITVTDVKDELLDNIEDSEW--HPQWARdNRFRDFVADA-PDWNISRQR-YWGIPLPiwes 468
Cdd:cd00814 122 LYCVSCERFLPewreEEHYFFRLSKFQDRLLEWLEKNPDfiWPENAR-NEVLSWLKEGlKDLSITRDLfDWGIPVP---- 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 469 edgeDFivvgtreelaeradqdvdpgeldlhrpsvdpltitEDGTTYervpdvfdVWID------SSVATWGTLDypGNE 542
Cdd:cd00814 197 ----LD-----------------------------------PGKVIY--------VWFDaligyiSATGYYNEEW--GNS 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 543 TDFEELWPADLIVEAHDQTR--GWFWSQLGMGTaarGEIPYEEVLMHGFANDEnGRKMSKSLGNIVTPEEAIDRAGRDPL 620
Cdd:cd00814 228 WWWKDGWPELVHFIGKDIIRfhAIYWPAMLLGA---GLPLPTRIVAHGYLTVE-GKKMSKSRGNVVDPDDLLERYGADAL 303
|
250
....*....|....*.
gi 492946146 621 RAYLLSHDQQGVDLSF 636
Cdd:cd00814 304 RYYLLRERPEGKDSDF 319
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
47-186 |
1.02e-12 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 70.25 E-value: 1.02e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 47 PYTSGQMHLGTAWNKTLKDAIIRYKRMTGHRVTDRPGYDMHGLPIEVKVEEElgfetkrdieeyGMESfidecKSFAERN 126
Cdd:cd00814 9 PYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAEEE------------GVTP-----QELCDKY 71
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 127 REAMDDDFQSIGVwmDWDDPYKTLSPEYMEAAWWAFDQVADRGLVERGKRSVNYCPRCQT 186
Cdd:cd00814 72 HEIFKDLFKWLNI--SFDYFIRTTSPRHKEIVQEFFKKLYENGYIYEGEYEGLYCVSCER 129
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
409-638 |
2.46e-11 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 66.12 E-value: 2.46e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 409 DQWF--ITVTDVKDELLDNIEDSEWHPQWARDNrFRDFVadapdwNISRQRYWGIPLPIwesedgedfivvgtreelaer 486
Cdd:cd00812 130 DQWFlkYSETEWKEKLLKDLEKLDGWPEEVRAM-QENWI------GCSRQRYWGTPIPW--------------------- 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 487 adqdvdpgeldlhrpsvdpltitedgttyervPDVFDVWIDSS-------VATWGTLDYPGNET----DFEELWPADLIV 555
Cdd:cd00812 182 --------------------------------TDTMESLSDSTwyyarytDAHNLEQPYEGDLEfdreEFEYWYPVDIYI 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 556 EAHD---------------------QTRGWFwSQL---GMGTAargeipyeevlmhgfandeNGRKMSKSLGNIVTPEEA 611
Cdd:cd00812 230 GGKEhapnhllysrfnhkalfdeglVTDEPP-KGLivqGMVLL-------------------EGEKMSKSKGNVVTPDEA 289
|
250 260
....*....|....*....|....*..
gi 492946146 612 IDRAGRDPLRAYLLshDQQGVDLSFDW 638
Cdd:cd00812 290 IKKYGADAARLYIL--FAAPPDADFDW 314
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
638-764 |
1.12e-09 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 57.13 E-value: 1.12e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 638 WDGLADTQSALNIFWNVFRFPLPYMELDgydpaNPDLSAGELSVVDEWVLSRLQTVKADVADAWDDYEVHDALNAILDFV 717
Cdd:cd07375 1 EERLKQARAFLNRLYRLLSFFRKALGGT-----QPKWDNELLEEADRELLARLQEFIKRTTNALEALDPTTAVQELFKFT 75
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 492946146 718 TEDvsRFYVKAIRERMWEEEDSESKRGAYATLATVLnetVQLIAPFT 764
Cdd:cd07375 76 NEL--NWYLDELKPALQTEELREAVLAVLRAALVVL---TKLLAPFT 117
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
586-753 |
5.29e-08 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 56.65 E-value: 5.29e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 586 MH-GFANDeNGRKMSKSLGNIVTPEEAIDRAGRDPLRAYLLS-HDQQGVDlsFDWDGLADTQSALNIFWNVFRFplpyme 663
Cdd:COG0215 254 MHnGFLTV-NGEKMSKSLGNFFTVRDLLKKYDPEVLRFFLLSaHYRSPLD--FSEEALEEAEKALERLYNALRR------ 324
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 664 ldgydpanpdlsAGELSVVDEWVLSRLQTVKADVADAW-DDYEVHDALNAILDFVTEdvsrfyVKAIRERMWEEEDSESK 742
Cdd:COG0215 325 ------------LEEALGAADSSAEEIEELREEFIAAMdDDFNTPEALAVLFELVRE------INKALDEGEDKAALAAL 386
|
170
....*....|.
gi 492946146 743 RGAYATLATVL 753
Cdd:COG0215 387 AALLRALGGVL 397
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
677-773 |
3.78e-07 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 49.90 E-value: 3.78e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 677 GELSVVDEWVLSRLQTVKADVADAWDDYEVHDALNAILDFVTEDVsRFYVKAIRERMWEEedseskrgayaTLATVLNET 756
Cdd:cd07959 31 EELTFIDRWLLSRLNRLIKETTEAYENMQFREALKEGLYELQNDL-DWYRERGGAGMNKD-----------LLRRFIEVW 98
|
90
....*....|....*..
gi 492946146 757 VQLIAPFTPYVAERMYQ 773
Cdd:cd07959 99 TRLLAPFAPHLAEEIWH 115
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
518-775 |
1.86e-06 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 52.08 E-value: 1.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 518 VPD----VFDVWID------SSVATWGTLdypGNETDFEELWPADLIVEAH-----DQTR--GWFWSqlGMGTAARGEIP 580
Cdd:PRK00133 240 IPGapgkVFYVWLDapigyiSSTKNLCDK---RGGLDWDEYWKKDSDTELYhfigkDIIYfhTLFWP--AMLEGAGYRLP 314
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 581 YEeVLMHGFANdENGRKMSKSLGNIVTPEEAIDRAGRDPLRAYL---LSHDQQGVDLSFDwDGLADTQSAL-NIFWN--- 653
Cdd:PRK00133 315 TN-VFAHGFLT-VEGAKMSKSRGTFIWARTYLDHLDPDYLRYYLaakLPETIDDLDFNWE-DFQQRVNSELvGKVVNfas 391
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 654 ---VF---RFplpymelDGYDPAnpdlsagelSVVDEWVLSRLQTVKADVADAWDDYEVHDALNAILdfvteDVSRFYVK 727
Cdd:PRK00133 392 rtaGFinkRF-------DGKLPD---------ALADPELLEEFEAAAEKIAEAYEAREFRKALREIM-----ALADFANK 450
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 492946146 728 AIRERM-WEEEDSESKRgayatLATVLNETVQL-------IAPFTPYVAERMYQHL 775
Cdd:PRK00133 451 YVDDNEpWKLAKQDGER-----LQAVCSVGLNLfralaiyLKPVLPELAERAEAFL 501
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
47-185 |
2.98e-05 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 48.22 E-value: 2.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 47 PYTSGQMHLG-------TawnktlkDAIIRYKRMTGHRVTDRPGYDMHGLPIEVKVEEElgfetkrdieeyGM--ESFID 117
Cdd:PRK00133 11 PYANGPIHLGhlveyiqA-------DIWVRYQRMRGHEVLFVCADDAHGTPIMLKAEKE------------GItpEELIA 71
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 492946146 118 ECksfaernREAMDDDFQSIGVwmDWDDPYKTLSPEYMEAAWWAFDQVADRGLVERGKRSVNYCPRCQ 185
Cdd:PRK00133 72 RY-------HAEHKRDFAGFGI--SFDNYGSTHSEENRELAQEIYLKLKENGYIYEKTIEQLYDPEKG 130
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
524-639 |
5.88e-05 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 47.02 E-value: 5.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 524 VWIDSSVATWGTLDYPGNETDFEEL----WPADLIVEAHDQTR--GWFWSQLGMgtAARGEIPyEEVLMHGFANdENGRK 597
Cdd:PLN02224 291 VWFDALLGYISALTEDNKQQNLETAvsfgWPASLHLIGKDILRfhAVYWPAMLM--SAGLELP-KMVFGHGFLT-KDGMK 366
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 492946146 598 MSKSLGNIVTPEEAIDRAGRDPLRAYLLSHDQQGVDLSFDWD 639
Cdd:PLN02224 367 MGKSLGNTLEPFELVQKFGPDAVRYFFLREVEFGNDGDYSED 408
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
12-111 |
4.00e-04 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 44.68 E-value: 4.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 12 DIESVVGDYWDEENAYEATKEAHADDPA-FFFVDGP-PYTSGQMHLGTAWNKTLKDAIIRYKRMTGHRVTDRPGYDMHGL 89
Cdd:PLN02959 17 EIEVAVQKWWEEEKVFEAEAGDEPPKPGeKFFGNFPyPYMNGLLHLGHAFSLSKLEFAAAYHRLRGANVLLPFAFHCTGM 96
|
90 100
....*....|....*....|..
gi 492946146 90 PIEVKVEeelgfETKRDIEEYG 111
Cdd:PLN02959 97 PIKASAD-----KLAREIQQYG 113
|
|
| Anticodon_Ia_Met |
cd07957 |
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA ... |
677-775 |
7.34e-04 |
|
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA synthetases (MetRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon (CAU). MetRS catalyzes the transfer of methionine to the 3'-end of its tRNA.
Pssm-ID: 153411 [Multi-domain] Cd Length: 129 Bit Score: 40.55 E-value: 7.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 677 GELSVVDEWVLSRLQTVKADVADAWDDYEVHDALNAILDFVtedvsRFYVKAIRERM-WE---EEDSESkrgayatLATV 752
Cdd:cd07957 32 GGLTEEDEELLEEAEELLEEVAEAMEELEFRKALEEIMELA-----RAANKYIDETApWKlakEEDPER-------LATV 99
|
90 100 110
....*....|....*....|....*....|
gi 492946146 753 LNETVQ-------LIAPFTPYVAERMYQHL 775
Cdd:cd07957 100 LYVLLEllrilaiLLSPFMPETAEKILDQL 129
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
594-627 |
2.96e-03 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 40.25 E-value: 2.96e-03
10 20 30
....*....|....*....|....*....|....
gi 492946146 594 NGRKMSKSLGNIVTPEEAIDRAGRDPLRAYLLSH 627
Cdd:cd00672 171 DGEKMSKSLGNFITVRDALKKYDPEVLRLALLSS 204
|
|
| ArgS |
COG0018 |
Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Arginyl-tRNA ... |
583-639 |
3.85e-03 |
|
Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Arginyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439789 [Multi-domain] Cd Length: 574 Bit Score: 41.29 E-value: 3.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 583 EVLMHGFANDENGRKMSKSLGNIVTP----EEAIDRA-------------------GRDPLRAYLLSHDQQGvDLSFDWD 639
Cdd:COG0018 365 EHLLFGMVNLRDGEKMSTRAGTVVTLddllDEAVERAreiieekseeekeeiaeqvGIDAVRYFDLSRSRDK-DLDFDLD 443
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
203-378 |
7.74e-03 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 38.68 E-value: 7.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 203 IYVKFPLEDREGSLVIWTTTPWTIPANTFVAV--DGEMTYQAvrAEKGGE-----SEVLYL--AEPCVEDVLKKGRYEDY 273
Cdd:pfam13603 10 AEITFPVEGTDEKIEVFTTRPDTLMGVTFVALapEHPLVEKL--AEKNPEvaafiEECKNTseIERTSETKEKEGVFTGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492946146 274 EVVEELSGEEMvgweydnplaghlneyadfegagEVYTAEYVEADR-TGLVHSAPGHGQED--FARGQDLGL-DVFVPVD 349
Cdd:pfam13603 88 YAIHPITGEKI-----------------------PIWIANFVLMEYgTGAVMAVPAHDQRDfeFAKKYNLPIkPVIQPED 144
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 492946146 350 GRGEFT--EQA----------GDYAGTFVRDANPDIIEDLE 378
Cdd:pfam13603 145 GDLDLDimTEAyteegilvnsGEFDGLDSEEAKEAIIKKLE 185
|
|
| |
