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Conserved domains on  [gi|492743171|ref|WP_005945334|]
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MULTISPECIES: calcium/sodium antiporter [Phocaeicola]

Protein Classification

sodium:calcium antiporter( domain architecture ID 11424992)

sodium:calcium antiporter facilitates Na(+)/Ca(2+) exchange

Gene Ontology:  GO:0008273|GO:0006874
PubMed:  22287543|23506883
SCOP:  4006475
TCDB:  2.A.19

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
21-316 2.48e-97

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


:

Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 288.96  E-value: 2.48e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492743171  21 LTDGSAAVAKRFRISDLVIGLTIVAFGTSAPELVISVLSALNGSAEMAIGNVVGSNTFNALMIIGCTAVVLPIKVGEGTM 100
Cdd:COG0530    4 LVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRPLAVDRRVL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492743171 101 SKEIPLVILSSLVLFFCANDvmldqgneNIIGRIDGLILLAFFLIFLRYTFAIARNGGEEVGEEQKI---KEMPVWKSVL 177
Cdd:COG0530   84 RRDLPFLLLASLLLLALLLD--------GTLSRIDGVILLLLYVLYLYYLIRRARKEPAWEEVEEELeekPKMSLWKALL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492743171 178 FIVGGLAGLIFGGQLFVEGASGIARSLGVSESVIGLTLVAGGTSLPELATSVTAALKKNPGIAIGNVIGSNLFNIFFVLG 257
Cdd:COG0530  156 LLVLGLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGSNIFNILLVLG 235

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 492743171 258 CSATISPLPMGG-INNLDLTVMIASALLLWLVgwFFKKRTITRPEGVLMMVCYVAYTAYL 316
Cdd:COG0530  236 IGALITPIPVDPaVLSFDLPVMLAATLLLLGL--LRTGGRIGRWEGLLLLALYLAYLALL 293
 
Name Accession Description Interval E-value
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
21-316 2.48e-97

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 288.96  E-value: 2.48e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492743171  21 LTDGSAAVAKRFRISDLVIGLTIVAFGTSAPELVISVLSALNGSAEMAIGNVVGSNTFNALMIIGCTAVVLPIKVGEGTM 100
Cdd:COG0530    4 LVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRPLAVDRRVL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492743171 101 SKEIPLVILSSLVLFFCANDvmldqgneNIIGRIDGLILLAFFLIFLRYTFAIARNGGEEVGEEQKI---KEMPVWKSVL 177
Cdd:COG0530   84 RRDLPFLLLASLLLLALLLD--------GTLSRIDGVILLLLYVLYLYYLIRRARKEPAWEEVEEELeekPKMSLWKALL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492743171 178 FIVGGLAGLIFGGQLFVEGASGIARSLGVSESVIGLTLVAGGTSLPELATSVTAALKKNPGIAIGNVIGSNLFNIFFVLG 257
Cdd:COG0530  156 LLVLGLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGSNIFNILLVLG 235

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 492743171 258 CSATISPLPMGG-INNLDLTVMIASALLLWLVgwFFKKRTITRPEGVLMMVCYVAYTAYL 316
Cdd:COG0530  236 IGALITPIPVDPaVLSFDLPVMLAATLLLLGL--LRTGGRIGRWEGLLLLALYLAYLALL 293
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 21-312 1.52e-58

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 190.23  E-value: 1.52e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492743171   21 LTDGSAAVAKRFRISDLVIGLTIVAFGTSAPELVISVLSALNGSAEMAIGNVVGSNTFNALMIIGCTAVVLPIKVGEGTM 100
Cdd:TIGR00367  21 FVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNILLILGLSAIFSPIIVDKDWL 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492743171  101 SKEIPLVILSSLVLFFcandVMLDqgneNIIGRIDGLILLAFFLIFLRYTFAIARNGGEEVGEEQKIKEMPVWKSVLF-- 178
Cdd:TIGR00367 101 RRDILFYLLVSILLLF----FGLD----GQISRIDGVVLLILYIVYLLFLVKNERWVKYDTYTEENLDENNRRPQIFFsl 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492743171  179 --IVGGLAGLIFGGQLFVEGASGIARSLGVSESVIGLTLVAGGTSLPELATSVTAALKKNPGIAIGNVIGSNLFNIFFVL 256
Cdd:TIGR00367 173 vlLIIGLIGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAVGNVIGSNIFNILVGL 252

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 492743171  257 GCSATISPLPMGG-INNLDLTVMIASALLLWLVGWFfkKRTITRPEGVLMMVCYVAY 312
Cdd:TIGR00367 253 GVPSLFMPIPVEPlAYNLDAPVMVIVTLLLMLFFKT--SMKLGRWEGILLLALYIAY 307
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 24-316 1.17e-53

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 178.30  E-value: 1.17e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492743171  24 GSAAVAKRFRISDLVIGLTIVAFGTSAPELVISVLSALNGSAEMAIGNVVGSNTFNALMIIGCTAVVLPIKVGEGTMSKE 103
Cdd:PRK10734  25 AASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITNILLILGLAALIRPFTVHSDVLRRE 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492743171 104 IPLVILSSLVLFFCANDVMLDqgneniigRIDGLILLAFFLIFLRYTFAIAR----NGGEEVGEEQkIKEMPVWKS---- 175
Cdd:PRK10734 105 LPLMLLVSVLAGSVLYDGQLS--------RSDGIFLLLLAVLWLLFIVKIARlaerQGNDSLTREQ-LAELPREGGlpva 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492743171 176 VLFIVGGLAGLIFGGQLFVEGASGIARSLGVSESVIGLTLVAGGTSLPELATSVTAALKKNPGIAIGNVIGSNLFNIFFV 255
Cdd:PRK10734 176 FLWLGIALIIMPMATRMVIDNATVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIV 255

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 492743171 256 LGCSATISPlpmGGINNL----DLTVMIASALLLWLVGWfFKKRTITRPEGVLMMVCYVAYTAYL 316
Cdd:PRK10734 256 LGLPALISP---GEINPLafsrDYWVMLLVSVIFALLCW-RRKRRIGRGAGALLLGGFIVWLAML 316
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 174-317 2.98e-23

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 93.44  E-value: 2.98e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492743171  174 KSVLFIVGGLAGLIFGGQLFVEGASGIARSLGVSESVIGLTLVAGGTSLPELATSVTAALKKNPGIAIGNVIGSNLFNIF 253
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 492743171  254 FVLGCSATISPLPMGGIN-NLDLTVMIASALLLW---LVGWFFKKRTITRPEGVLMMVCYVAYTAYLI 317
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLlKLDLGVLLLVALLLLlllLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQI 148
 
Name Accession Description Interval E-value
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
21-316 2.48e-97

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 288.96  E-value: 2.48e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492743171  21 LTDGSAAVAKRFRISDLVIGLTIVAFGTSAPELVISVLSALNGSAEMAIGNVVGSNTFNALMIIGCTAVVLPIKVGEGTM 100
Cdd:COG0530    4 LVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRPLAVDRRVL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492743171 101 SKEIPLVILSSLVLFFCANDvmldqgneNIIGRIDGLILLAFFLIFLRYTFAIARNGGEEVGEEQKI---KEMPVWKSVL 177
Cdd:COG0530   84 RRDLPFLLLASLLLLALLLD--------GTLSRIDGVILLLLYVLYLYYLIRRARKEPAWEEVEEELeekPKMSLWKALL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492743171 178 FIVGGLAGLIFGGQLFVEGASGIARSLGVSESVIGLTLVAGGTSLPELATSVTAALKKNPGIAIGNVIGSNLFNIFFVLG 257
Cdd:COG0530  156 LLVLGLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGSNIFNILLVLG 235

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 492743171 258 CSATISPLPMGG-INNLDLTVMIASALLLWLVgwFFKKRTITRPEGVLMMVCYVAYTAYL 316
Cdd:COG0530  236 IGALITPIPVDPaVLSFDLPVMLAATLLLLGL--LRTGGRIGRWEGLLLLALYLAYLALL 293
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 21-312 1.52e-58

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 190.23  E-value: 1.52e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492743171   21 LTDGSAAVAKRFRISDLVIGLTIVAFGTSAPELVISVLSALNGSAEMAIGNVVGSNTFNALMIIGCTAVVLPIKVGEGTM 100
Cdd:TIGR00367  21 FVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNILLILGLSAIFSPIIVDKDWL 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492743171  101 SKEIPLVILSSLVLFFcandVMLDqgneNIIGRIDGLILLAFFLIFLRYTFAIARNGGEEVGEEQKIKEMPVWKSVLF-- 178
Cdd:TIGR00367 101 RRDILFYLLVSILLLF----FGLD----GQISRIDGVVLLILYIVYLLFLVKNERWVKYDTYTEENLDENNRRPQIFFsl 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492743171  179 --IVGGLAGLIFGGQLFVEGASGIARSLGVSESVIGLTLVAGGTSLPELATSVTAALKKNPGIAIGNVIGSNLFNIFFVL 256
Cdd:TIGR00367 173 vlLIIGLIGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAVGNVIGSNIFNILVGL 252

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 492743171  257 GCSATISPLPMGG-INNLDLTVMIASALLLWLVGWFfkKRTITRPEGVLMMVCYVAY 312
Cdd:TIGR00367 253 GVPSLFMPIPVEPlAYNLDAPVMVIVTLLLMLFFKT--SMKLGRWEGILLLALYIAY 307
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 24-316 1.17e-53

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 178.30  E-value: 1.17e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492743171  24 GSAAVAKRFRISDLVIGLTIVAFGTSAPELVISVLSALNGSAEMAIGNVVGSNTFNALMIIGCTAVVLPIKVGEGTMSKE 103
Cdd:PRK10734  25 AASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITNILLILGLAALIRPFTVHSDVLRRE 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492743171 104 IPLVILSSLVLFFCANDVMLDqgneniigRIDGLILLAFFLIFLRYTFAIAR----NGGEEVGEEQkIKEMPVWKS---- 175
Cdd:PRK10734 105 LPLMLLVSVLAGSVLYDGQLS--------RSDGIFLLLLAVLWLLFIVKIARlaerQGNDSLTREQ-LAELPREGGlpva 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492743171 176 VLFIVGGLAGLIFGGQLFVEGASGIARSLGVSESVIGLTLVAGGTSLPELATSVTAALKKNPGIAIGNVIGSNLFNIFFV 255
Cdd:PRK10734 176 FLWLGIALIIMPMATRMVIDNATVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIV 255

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 492743171 256 LGCSATISPlpmGGINNL----DLTVMIASALLLWLVGWfFKKRTITRPEGVLMMVCYVAYTAYL 316
Cdd:PRK10734 256 LGLPALISP---GEINPLafsrDYWVMLLVSVIFALLCW-RRKRRIGRGAGALLLGGFIVWLAML 316
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
192-319 1.32e-33

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 124.86  E-value: 1.32e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492743171 192 LFVEGASGIARSLGVSESVIGLTLVAGGTSLPELATSVTAALKKNPGIAIGNVIGSNLFNIFFVLGCSATISPLPM-GGI 270
Cdd:COG0530    3 LLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRPLAVdRRV 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 492743171 271 NNLDLTVMIASALLLWLVGWFfkkRTITRPEGVLMMVCYVAYTAYLIAQ 319
Cdd:COG0530   83 LRRDLPFLLLASLLLLALLLD---GTLSRIDGVILLLLYVLYLYYLIRR 128
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 174-317 2.98e-23

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 93.44  E-value: 2.98e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492743171  174 KSVLFIVGGLAGLIFGGQLFVEGASGIARSLGVSESVIGLTLVAGGTSLPELATSVTAALKKNPGIAIGNVIGSNLFNIF 253
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 492743171  254 FVLGCSATISPLPMGGIN-NLDLTVMIASALLLW---LVGWFFKKRTITRPEGVLMMVCYVAYTAYLI 317
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLlKLDLGVLLLVALLLLlllLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQI 148
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 176-317 8.72e-19

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 85.08  E-value: 8.72e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492743171 176 VLFIVGgLAGLIFGGQLFVEGASGIARSLGVSESVIGLTLVAGGTSLPELATSVTAALKKNPGIAIGNVIGSNLFNIFFV 255
Cdd:PRK10734   6 ALLIIG-LLLLVYGADRLVFAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITNILLI 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 492743171 256 LGCSATISPLPM-GGINNLDLTVMIASALLlwlVGWFFKKRTITRPEGVLMMVCYVAYTAYLI 317
Cdd:PRK10734  85 LGLAALIRPFTVhSDVLRRELPLMLLVSVL---AGSVLYDGQLSRSDGIFLLLLAVLWLLFIV 144
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 21-151 1.12e-17

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 78.41  E-value: 1.12e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492743171   21 LTDGSAAVAKRFRISDLVIGLTIVAFGTSAPELVISVLSALNGSAEMAIGNVVGSNTFNALMIIGCTAVVLPIKVGEGTM 100
Cdd:pfam01699  20 LVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNILLVLGLSALIGPVKVDSLLL 99

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 492743171  101 SKEIPLVILSSLVLFFCAndVMLDQGNENIIGRIDGLILLAFFLIFLRYTF 151
Cdd:pfam01699 100 KLDLGVLLLVALLLLLLL--LLLLLPLFGRLSRFEGLVLLLLYIVYLVFQI 148
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 176-312 2.82e-11

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 64.63  E-value: 2.82e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492743171   176 VLFIVGGL----AGLIFGGQLFVEGASGIARSLGVSESVIGLTLVAGGTSLPELATSVTAALKKNPGIAIGNVIGSNLFN 251
Cdd:TIGR00927  458 VLHIFGMMyvfvALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFN 537

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 492743171   252 IFFVLGCSATISPlpmgGINNL-------DLTVMIASALLLWLvgwFFKKRTITRPEGVLMMVCYVAY 312
Cdd:TIGR00927  538 ILFVIGTCALFSR----EILNLtwwplfrDVSFYILDLMMLIL---FFLDSLIAWWESLLLLLAYALY 598
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 192-252 2.56e-09

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 58.47  E-value: 2.56e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 492743171   192 LFVEGASGIARSLGVSESVIGLTLVAGGTSLPELATSVTAALKKNPGIAIGNVIGSNLFNI 252
Cdd:TIGR00927  951 LMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDI 1011
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 28-174 2.17e-08

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 55.39  E-value: 2.17e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492743171    28 VAKRFRISDLVIGLTIVAFGTSAPELVISVLSALNGSAEMAIGNVVGSNTFNALMIIGCTAVvlpikvgegtMSKEI--- 104
Cdd:TIGR00927  486 ITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCAL----------FSREIlnl 555

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492743171   105 ---PL--------VILSSLVLFFcandvmLDqgneNIIGRIDGLILLaffLIFLRYTFAIARNGGEEVGEEQKIKEMPVW 173
Cdd:TIGR00927  556 twwPLfrdvsfyiLDLMMLILFF------LD----SLIAWWESLLLL---LAYALYVFTMKWNKQIELWVKEQLSRRPVA 622


                   .
gi 492743171   174 K 174
Cdd:TIGR00927  623 K 623
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 28-79 8.80e-08

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 53.46  E-value: 8.80e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 492743171    28 VAKRFRISDLVIGLTIVAFGTSAPELVISVLSALNGSAEMAIGNVVGSNTFN 79
Cdd:TIGR00927  959 VGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFD 1010
ChaA COG0387
Cation (Ca2+/Na+/K+)/H+ antiporter ChaA [Inorganic ion transport and metabolism];
136-312 1.81e-06

Cation (Ca2+/Na+/K+)/H+ antiporter ChaA [Inorganic ion transport and metabolism];


Pssm-ID: 440156 [Multi-domain]  Cd Length: 362  Bit Score: 49.00  E-value: 1.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492743171 136 GLILLAFFLIFL-------RYTF-AIARNGGEEVGEEQKIKEMPVWKSVLFIVGGLAGLIFGGQLFVEGASGIARSLGVS 207
Cdd:COG0387  171 AIVLLVLYGLFLlfqtvthRDYFlPEDEGEEDEDEHEEPPSKWSLLLSLGLLLVALVAVVLLSEILVGSIEEAVEALGLP 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492743171 208 ESVIGLtLVAGGTSLPELATSVTAALKKNPGIAIGNVIGSNLFNIFFVLGCSATISPL---PMG-GINNLDLTVMIASAL 283
Cdd:COG0387  251 EAFVGV-IIAILVLAPEGLTAVRAARKNRLQLSLNIALGSALASIGLTIPALVLISLLtgqPLTlGFNPFELVLLALTVL 329

                        170       180
                 ....*....|....*....|....*....
gi 492743171 284 LLWLVgwFFKKRTiTRPEGVLMMVCYVAY 312
Cdd:COG0387  330 VSNLT--FSDGRT-NWLEGAVHLALFAIY 355
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 177-263 1.26e-05

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 46.71  E-value: 1.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492743171  177 LFIVGGLAGLIfgGQLfvegASGIARSLGVSESVIGLTLVAGGTSLPELATSVTAALK-KNPGIAIGNVIGSNLFNIFFV 255
Cdd:TIGR00845 763 ILMIGVLTAFI--GDL----ASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQdQYADASIGNVTGSNAVNVFLG 836


                  ....*...
gi 492743171  256 LGCSATIS 263
Cdd:TIGR00845 837 IGVAWSIA 844
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 33-92 5.78e-05

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 44.78  E-value: 5.78e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 492743171   33 RI-SDLVIGLTIVAFGTSAPELVISVLSALNG---SAEMAIGNVVGSNTFNALMIIGCTAVVLP 92
Cdd:TIGR00845 125 RIwNETVSNLTLMALGSSAPEILLSVIEVCGHnfeAGDLGPSTIVGSAAFNMFIIIAICVYVIP 188
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 34-85 1.24e-04

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 43.63  E-value: 1.24e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 492743171   34 ISDLVIGLTIVAFGTSAPELVISVLSALNGS-AEMAIGNVVGSNTFNALMIIG 85
Cdd:TIGR00845 786 LKDSVTAVVFVALGTSVPDTFASKVAATQDQyADASIGNVTGSNAVNVFLGIG 838
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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