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Conserved domains on  [gi|492444165|ref|WP_005845863|]
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MULTISPECIES: GNAT family N-acetyltransferase [Phocaeicola]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10456837)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  15581578|10940244|9175471|27367672|26818562
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 18-127 1.96e-10

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


:

Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 55.60  E-value: 1.96e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492444165   18 VEKLMHTAFPQEERRDTVQQREYSDNNPRFCNNIILENGNSIGMISYWTMGDF---YYIEHFAIDPSLRNGGYGKRVLEM 94
Cdd:pfam00583   4 LYELLSEEFPEPWPDEPLDLLEDWDEDASEGFFVAEEDGELVGFASLSIIDDEppvGEIEGLAVAPEYRGKGIGTALLQA 83

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 492444165   95 IKKQLKGP----IVLEVEEPNdemsTRRIHFYKRLEF 127
Cdd:pfam00583  84 LLEWARERgcerIFLEVAADN----LAAIALYEKLGF 116
 
Name Accession Description Interval E-value
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 18-127 1.96e-10

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 55.60  E-value: 1.96e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492444165   18 VEKLMHTAFPQEERRDTVQQREYSDNNPRFCNNIILENGNSIGMISYWTMGDF---YYIEHFAIDPSLRNGGYGKRVLEM 94
Cdd:pfam00583   4 LYELLSEEFPEPWPDEPLDLLEDWDEDASEGFFVAEEDGELVGFASLSIIDDEppvGEIEGLAVAPEYRGKGIGTALLQA 83

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 492444165   95 IKKQLKGP----IVLEVEEPNdemsTRRIHFYKRLEF 127
Cdd:pfam00583  84 LLEWARERgcerIFLEVAADN----LAAIALYEKLGF 116
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
18-140 1.38e-08

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 51.24  E-value: 1.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492444165  18 VEKLMHTAFPQEERRDTVQQREYSDNNPRFCnnIILENGNSIGMISYWTM-----GDFYYIEHFAIDPSLRNGGYGKRVL 92
Cdd:COG3153   12 IAALLRAAFGPGREAELVDRLREDPAAGLSL--VAEDDGEIVGHVALSPVdidgeGPALLLGPLAVDPEYRGQGIGRALM 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 492444165  93 EMIKKQLK----GPIVLEVEEpndemstRRIHFYKRLEFTLHKKPYIQPPYR 140
Cdd:COG3153   90 RAALEAARergaRAVVLLGDP-------SLLPFYERFGFRPAGELGLTLGPD 134
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 51-100 2.58e-06

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 43.03  E-value: 2.58e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 492444165  51 IILENGNSIGMISYW---TMGDFYYIEHFAIDPSLRNGGYGKRVLEMIKKQLK 100
Cdd:cd04301    3 VAEDDGEIVGFASLSpdgSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEAR 55
 
Name Accession Description Interval E-value
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 18-127 1.96e-10

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 55.60  E-value: 1.96e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492444165   18 VEKLMHTAFPQEERRDTVQQREYSDNNPRFCNNIILENGNSIGMISYWTMGDF---YYIEHFAIDPSLRNGGYGKRVLEM 94
Cdd:pfam00583   4 LYELLSEEFPEPWPDEPLDLLEDWDEDASEGFFVAEEDGELVGFASLSIIDDEppvGEIEGLAVAPEYRGKGIGTALLQA 83

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 492444165   95 IKKQLKGP----IVLEVEEPNdemsTRRIHFYKRLEF 127
Cdd:pfam00583  84 LLEWARERgcerIFLEVAADN----LAAIALYEKLGF 116
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
18-140 1.38e-08

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 51.24  E-value: 1.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492444165  18 VEKLMHTAFPQEERRDTVQQREYSDNNPRFCnnIILENGNSIGMISYWTM-----GDFYYIEHFAIDPSLRNGGYGKRVL 92
Cdd:COG3153   12 IAALLRAAFGPGREAELVDRLREDPAAGLSL--VAEDDGEIVGHVALSPVdidgeGPALLLGPLAVDPEYRGQGIGRALM 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 492444165  93 EMIKKQLK----GPIVLEVEEpndemstRRIHFYKRLEFTLHKKPYIQPPYR 140
Cdd:COG3153   90 RAALEAARergaRAVVLLGDP-------SLLPFYERFGFRPAGELGLTLGPD 134
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 60-128 2.96e-08

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 48.88  E-value: 2.96e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 492444165  60 GMISYWT--MGDFYYIEHFAIDPSLRNGGYGKRVLEMIKKQLK----GPIVLEVEEPNdemsTRRIHFYKRLEFT 128
Cdd:COG0456    1 GFALLGLvdGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARergaRRLRLEVREDN----EAAIALYEKLGFE 71
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 51-128 5.43e-08

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 48.22  E-value: 5.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492444165   51 IILENGNSIGMISYWTMGDFYYIEH--FAIDPSLRNGGYGKRVLEMIKKQLKGPIVLEVEEPNDEmstRRIHFYKRLEFT 128
Cdd:pfam13508   7 VAEDDGKIVGFAALLPLDDEGALAElrLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELETTN---RAAAFYEKLGFE 83
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 51-100 2.58e-06

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 43.03  E-value: 2.58e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 492444165  51 IILENGNSIGMISYW---TMGDFYYIEHFAIDPSLRNGGYGKRVLEMIKKQLK 100
Cdd:cd04301    3 VAEDDGEIVGFASLSpdgSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEAR 55
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 51-150 2.76e-04

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 39.20  E-value: 2.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492444165  51 IILENGNSIGMISYWTM-GDFYYIEHFAIDPSLRNGGYGKRVLEMIKKQLKG----PIVLEVeepndemSTRRIHFYKRL 125
Cdd:COG1246   32 VAEEDGEIVGCAALHPLdEDLAELRSLAVHPDYRGRGIGRRLLEALLAEARElglkRLFLLT-------TSAAIHFYEKL 104

                         90       100
                 ....*....|....*....|....*
gi 492444165 126 EFTLHKKPYIQPPYRKGDSGLPMLL 150
Cdd:COG1246  105 GFEEIDKEDLPYAKVWQRDSVVMEK 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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