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Conserved domains on  [gi|492427133|ref|WP_005840816|]
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MULTISPECIES: transcriptional regulator [Phocaeicola]

Protein Classification

winged helix-turn-helix domain-containing protein( domain architecture ID 10612879)

winged helix-turn-helix (wHTH) domain-containing protein binds DNA and may function as a transcriptional regulator

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|10473770|8831795
SCOP:  3000034

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_34 pfam13601
Winged helix DNA-binding domain;
13-92 3.62e-39

Winged helix DNA-binding domain;


:

Pssm-ID: 463932 [Multi-domain]  Cd Length: 80  Bit Score: 125.06  E-value: 3.62e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492427133  13 LRLAVMSILVSVEEAEFSYLKQQTGATAGNLSVQIDKLNKAGYVEVIKTFKGKMPCTICKITLKGLEAFEEYVDALKSYI 92
Cdd:pfam13601  1 VRLAIMSYLASVDEADFVELKEALEATDGNLSVHLRKLEKAGYIECDKSFVGRKPRTLYRITPEGREAFEDYVKALKRLI 80
 
Name Accession Description Interval E-value
HTH_34 pfam13601
Winged helix DNA-binding domain;
13-92 3.62e-39

Winged helix DNA-binding domain;


Pssm-ID: 463932 [Multi-domain]  Cd Length: 80  Bit Score: 125.06  E-value: 3.62e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492427133  13 LRLAVMSILVSVEEAEFSYLKQQTGATAGNLSVQIDKLNKAGYVEVIKTFKGKMPCTICKITLKGLEAFEEYVDALKSYI 92
Cdd:pfam13601  1 VRLAIMSYLASVDEADFVELKEALEATDGNLSVHLRKLEKAGYIECDKSFVGRKPRTLYRITPEGREAFEDYVKALKRLI 80
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
14-88 4.87e-03

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 33.79  E-value: 4.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492427133  14 RLAVMSILVSVEEAEFSYLKQQTGATAGNLSVQIDKLNKAGYVEviktfkgKMPC------TICKITLKGLEAFEEYVDA 87
Cdd:COG1846   40 QFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVE-------REPDpedrraVLVRLTEKGRALLEEARPA 112


                 .
gi 492427133  88 L 88
Cdd:COG1846  113 L 113
 
Name Accession Description Interval E-value
HTH_34 pfam13601
Winged helix DNA-binding domain;
13-92 3.62e-39

Winged helix DNA-binding domain;


Pssm-ID: 463932 [Multi-domain]  Cd Length: 80  Bit Score: 125.06  E-value: 3.62e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492427133  13 LRLAVMSILVSVEEAEFSYLKQQTGATAGNLSVQIDKLNKAGYVEVIKTFKGKMPCTICKITLKGLEAFEEYVDALKSYI 92
Cdd:pfam13601  1 VRLAIMSYLASVDEADFVELKEALEATDGNLSVHLRKLEKAGYIECDKSFVGRKPRTLYRITPEGREAFEDYVKALKRLI 80
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 8-63 2.34e-04

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 35.98  E-value: 2.34e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 492427133   8 LLHSELRLAVMSILVSVEEAEFSYLKQQTGATAGNLSVQIDKLNKAGYVEVIKTFK 63
Cdd:pfam12840  6 ALADPTRLRILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
14-88 4.87e-03

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 33.79  E-value: 4.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492427133  14 RLAVMSILVSVEEAEFSYLKQQTGATAGNLSVQIDKLNKAGYVEviktfkgKMPC------TICKITLKGLEAFEEYVDA 87
Cdd:COG1846   40 QFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVE-------REPDpedrraVLVRLTEKGRALLEEARPA 112


                 .
gi 492427133  88 L 88
Cdd:COG1846  113 L 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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