|
Name |
Accession |
Description |
Interval |
E-value |
| PRK15389 |
PRK15389 |
fumarate hydratase; Provisional |
2-537 |
0e+00 |
|
fumarate hydratase; Provisional
Pssm-ID: 237955 [Multi-domain] Cd Length: 536 Bit Score: 1198.57 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 2 ATPPFHYQHMFPLGPDKTEYYLLTKDYVSVSEFEGKPILKIEKEGLTAMANAAFRDVSFLLRRSHNEQVAKILSDPEASD 81
Cdd:PRK15389 1 SMPPFKYQDLFPLGKDDTEYRLLTSDGVSVAEFEGREILKVEPEALTLLAEEAFHDISHLLRPAHLQQLAKILDDPEASD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 82 NDKYVALTFLRNAEVSAKGKLPLCQDTGTAIIHGEKGQQVWTGYCDEEALSLGVYKTYTEENLRYSQNAPLTMYDEVNTK 161
Cdd:PRK15389 81 NDKFVALDLLKNANIAAGGVLPMCQDTGTAIIMGKKGQRVWTGGDDEEALSRGVYDTYTELNLRYSQNAPLDMYEEKNTG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 162 CNLPAQIDLEATEGMEYKFLCVTKGGGSANKTYLYQETKAVLNPATLVPFLVEKMKTLGTAACPPYHIAFVIGGTSAEKN 241
Cdd:PRK15389 161 TNLPAQIDIYATEGDEYKFLFMAKGGGSANKTFLYQETKALLNPDRLLAFLVEKMRTLGTAACPPYHLAIVIGGTSAEAN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 242 LLTVKLASTHYYDELPTTGNEYGRAFRDVELEKQVLEEAYKIGLGAQFGGKYMAHDVRIIRLPRHGASCPIGLGVSCSAD 321
Cdd:PRK15389 241 LKTVKLASAKYLDALPTEGNEHGHAFRDLELEQEVLKLTQKLGIGAQFGGKYFCHDVRVIRLPRHGASCPVGIGVSCSAD 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 322 RNIKCKINKDGIWIEKMDDKPGELIPAELREAGEGDVVKIDLNQPMADILKELTKYPVATRLSLNGTIIVGRDIAHAKLK 401
Cdd:PRK15389 321 RNIKAKITRDGIFLEQLETNPARYLPEVLREKLEGEVVKIDLNRPMAEILAELSKYPVKTRLSLTGTIIVARDIAHAKLK 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 402 ERLDRGEDLPQYIKDHPIYYAGPAKTPEGMACGSMGPTTAGRMDPYVDLFQSHGGSMIMLAKGNRSQQVTDACKKYGGFY 481
Cdd:PRK15389 401 ERLDAGEGLPQYLKDHPVYYAGPAKTPEGYASGSFGPTTAGRMDSYVDLFQAAGGSMVMLAKGNRSQQVTDACKKHGGFY 480
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*.
gi 492423503 482 LGSIGGPAAILAQNNIKSIECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFKQ 537
Cdd:PRK15389 481 LGSIGGPAARLAQDCIKKVEVLEYPELGMEAVWKIEVEDFPAFILVDDKGNDFFKE 536
|
|
| Fumerase_C |
pfam05683 |
Fumarase C-terminus; This family consists of the C terminal region of several bacterial ... |
332-537 |
2.67e-129 |
|
Fumarase C-terminus; This family consists of the C terminal region of several bacterial fumarate hydratase proteins (FumA and FumB). Fumarase, or fumarate hydratase (EC 4.2.1.2), is a component of the citric acid cycle. In facultative anaerobes such as Escherichia coli, fumarase also engages in the reductive pathway from oxaloacetate to succinate during anaerobic growth.
Pssm-ID: 461714 [Multi-domain] Cd Length: 204 Bit Score: 375.66 E-value: 2.67e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 332 GIWIEKMDDKPGELIPaELREAGEGDVVKIDLNQPmaDILKELTKYPVATRLSLNGTIIVGRDIAHAKLKERLDRGEDLP 411
Cdd:pfam05683 1 GSGPEQLEPPPLEYWP-EWEEDDLAEAVRVDLNRP--ETREELSKWPVGTRLLLSGTLLTGRDAAHKRIKEMLDKGEPLP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 412 QYIKD--HPIYYAGPAKTPEGMACGSMGPTTAGRMDPYVDLFQSHGGSMIMLAKGNRSQQVTDACKKYGGFYLGSIGGpA 489
Cdd:pfam05683 78 EYVDLngRPIYYAGPVDTPGGEVVGSAGPTTATRMDKYVDDFLEKGGSMGMIGKGNRGPAVTEACKKHGGFYLGAIGG-A 156
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 492423503 490 AILAQNNIKSIECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFKQ 537
Cdd:pfam05683 157 AYLAAKAIKKVEVVAFEELGMEAIWEFEVEDFPAFVAVDDKGNSFHKT 204
|
|
| TtdA |
COG1951 |
Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy ... |
41-334 |
1.20e-127 |
|
Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 441554 Cd Length: 289 Bit Score: 374.80 E-value: 1.20e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 41 KIEKEGLTAMANAAFRDVSFLLRRSHNEQVAKILSDpEASDNDKYVALTFLRNAEVSAKGKLPLCQDTGTAIIHGEKGQQ 120
Cdd:COG1951 3 EIDPEDLTEAVAELIIEASYYLPPDVLEALKEALEK-EESPNAKDVLAQILENAEIAAEGKLPICQDTGTAVVFVKIGQD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 121 VWTGYCDEEALSLGVYKTYTEENLRYSQNAPLTmydEVNTKCNLPAQIDLEATEGMEYKFLCVTKGGGSANKTYLYqetk 200
Cdd:COG1951 82 VPIDGDLEEAINEGVRRAYKEGPLRKSVVDPLT---RKNTGDNTPAVIHIEIVPGDKLEITVAPKGGGSENKSALK---- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 201 aVLNPAT----LVPFLVEKMKTLGTAACPPYHIAFVIGGTsAEKNLLTVKLASTHYYDELPttgneygRAFRDVELEKQV 276
Cdd:COG1951 155 -MLNPSEglegVKKFVLETVKEAGGNPCPPGIVGVGIGGT-AEKAAKLAKKALLRPLDERN-------PDPRLAELEEEL 225
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 492423503 277 LEEAYKIGLGAQ-FGGKYMAHDVRIIRLPRHGASCPIGLGVSCSADRNIKCKINKDGIW 334
Cdd:COG1951 226 LEAINKLGIGPQgLGGKTTALDVKIERAPRHIASLPVAVNINCWATRHATAVIDGDGPF 284
|
|
| ttdB_fumA_fumB |
TIGR00723 |
hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region; A number of Fe-S ... |
372-537 |
9.96e-79 |
|
hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region; A number of Fe-S cluster-containing hydro-lyases share a conserved motif, including argininosuccinate lyase, adenylosuccinate lyase, aspartase, class I fumarate hydratase (fumarase), and tartrate dehydratase (see PROSITE:PDOC00147). This model represents a subset of closely related proteins or modules, including the E. coli tartrate dehydratase beta chain and the C-terminal region of the class I fumarase (where the N-terminal region is homologous to the tartrate dehydratase alpha chain). The activity of archaeal proteins in this subfamily has not been established.
Pssm-ID: 129806 Cd Length: 168 Bit Score: 244.65 E-value: 9.96e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 372 KELTKYPVATRLSLNGTIIVGRDIAHAKLKERLDRGEDLPQYIKDHPIYYAGPAKTPEGMA-CGSMGPTTAGRMDPYVDL 450
Cdd:TIGR00723 1 EQILKLKVGDVVYLTGTIFTARDEAHARLLELIDEGKELPFDLNGSVIYHAGPIVTKNGEWeVVSVGPTTSARMNPFEPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 451 FQSHGGSMIMLAKGNRSQQVTDACKKYGGFYLGSIGGPAAILAQnNIKSIECVEYPELGM-EAIWKIEVEDF-PAFILVD 528
Cdd:TIGR00723 81 LLEKLGVMAIIGKGGMSKEVVEACRKYKAVYLAFPGGCAALLAQ-SVKKVEGVAWEDLGMpEAIWELEVEDFgPLIVAID 159
|
....*....
gi 492423503 529 DKGNDFFKQ 537
Cdd:TIGR00723 160 SHGNSIFQE 168
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK15389 |
PRK15389 |
fumarate hydratase; Provisional |
2-537 |
0e+00 |
|
fumarate hydratase; Provisional
Pssm-ID: 237955 [Multi-domain] Cd Length: 536 Bit Score: 1198.57 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 2 ATPPFHYQHMFPLGPDKTEYYLLTKDYVSVSEFEGKPILKIEKEGLTAMANAAFRDVSFLLRRSHNEQVAKILSDPEASD 81
Cdd:PRK15389 1 SMPPFKYQDLFPLGKDDTEYRLLTSDGVSVAEFEGREILKVEPEALTLLAEEAFHDISHLLRPAHLQQLAKILDDPEASD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 82 NDKYVALTFLRNAEVSAKGKLPLCQDTGTAIIHGEKGQQVWTGYCDEEALSLGVYKTYTEENLRYSQNAPLTMYDEVNTK 161
Cdd:PRK15389 81 NDKFVALDLLKNANIAAGGVLPMCQDTGTAIIMGKKGQRVWTGGDDEEALSRGVYDTYTELNLRYSQNAPLDMYEEKNTG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 162 CNLPAQIDLEATEGMEYKFLCVTKGGGSANKTYLYQETKAVLNPATLVPFLVEKMKTLGTAACPPYHIAFVIGGTSAEKN 241
Cdd:PRK15389 161 TNLPAQIDIYATEGDEYKFLFMAKGGGSANKTFLYQETKALLNPDRLLAFLVEKMRTLGTAACPPYHLAIVIGGTSAEAN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 242 LLTVKLASTHYYDELPTTGNEYGRAFRDVELEKQVLEEAYKIGLGAQFGGKYMAHDVRIIRLPRHGASCPIGLGVSCSAD 321
Cdd:PRK15389 241 LKTVKLASAKYLDALPTEGNEHGHAFRDLELEQEVLKLTQKLGIGAQFGGKYFCHDVRVIRLPRHGASCPVGIGVSCSAD 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 322 RNIKCKINKDGIWIEKMDDKPGELIPAELREAGEGDVVKIDLNQPMADILKELTKYPVATRLSLNGTIIVGRDIAHAKLK 401
Cdd:PRK15389 321 RNIKAKITRDGIFLEQLETNPARYLPEVLREKLEGEVVKIDLNRPMAEILAELSKYPVKTRLSLTGTIIVARDIAHAKLK 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 402 ERLDRGEDLPQYIKDHPIYYAGPAKTPEGMACGSMGPTTAGRMDPYVDLFQSHGGSMIMLAKGNRSQQVTDACKKYGGFY 481
Cdd:PRK15389 401 ERLDAGEGLPQYLKDHPVYYAGPAKTPEGYASGSFGPTTAGRMDSYVDLFQAAGGSMVMLAKGNRSQQVTDACKKHGGFY 480
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*.
gi 492423503 482 LGSIGGPAAILAQNNIKSIECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFKQ 537
Cdd:PRK15389 481 LGSIGGPAARLAQDCIKKVEVLEYPELGMEAVWKIEVEDFPAFILVDDKGNDFFKE 536
|
|
| PRK15391 |
PRK15391 |
class I fumarate hydratase; |
1-546 |
0e+00 |
|
class I fumarate hydratase;
Pssm-ID: 185289 [Multi-domain] Cd Length: 548 Bit Score: 1003.01 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 1 MATPPFHYQHMFPLGPDKTEYYLLTKDYVSVSEFEGKPILKIEKEGLTAMANAAFRDVSFLLRRSHNEQVAKILSDPEAS 80
Cdd:PRK15391 1 MSNKPFIYQAPFPMGKDNTEYYLLTSDYVSVADFDGETILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 81 DNDKYVALTFLRNAEVSAKGKLPLCQDTGTAIIHGEKGQQVWTGYCDEEALSLGVYKTYTEENLRYSQNAPLTMYDEVNT 160
Cdd:PRK15391 81 ENDKYVALQFLRNSEIAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGDEEALSKGVYNTYIEDNLRYSQNAALDMYKEVNT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 161 KCNLPAQIDLEATEGMEYKFLCVTKGGGSANKTYLYQETKAVLNPATLVPFLVEKMKTLGTAACPPYHIAFVIGGTSAEK 240
Cdd:PRK15391 161 GTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLGTAACPPYHIAFVIGGTSAET 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 241 NLLTVKLASTHYYDELPTTGNEYGRAFRDVELEKQVLEEAYKIGLGAQFGGKYMAHDVRIIRLPRHGASCPIGLGVSCSA 320
Cdd:PRK15391 241 NLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLEEAQKLGLGAQFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 321 DRNIKCKINKDGIWIEKMDDKPGELIPAELREAGEGDVVKIDLNQPMADILKELTKYPVATRLSLNGTIIVGRDIAHAKL 400
Cdd:PRK15391 321 DRNIKAKINREGIWIEKLEHNPGQYIPQELRQAGEGEAVKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 401 KERLDRGEDLPQYIKDHPIYYAGPAKTPEGMACGSMGPTTAGRMDPYVDLFQSHGGSMIMLAKGNRSQQVTDACKKYGGF 480
Cdd:PRK15391 401 KELIDAGKELPQYIKDHPIYYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGGF 480
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 492423503 481 YLGSIGGPAAILAQNNIKSIECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFKQLKPRCLGNC 546
Cdd:PRK15391 481 YLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIVNKQCANC 546
|
|
| PTZ00226 |
PTZ00226 |
fumarate hydratase; Provisional |
2-540 |
0e+00 |
|
fumarate hydratase; Provisional
Pssm-ID: 240319 [Multi-domain] Cd Length: 570 Bit Score: 983.76 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 2 ATPPFHYQHMFPL--GPDKTEYYLLTK--DYVSVSEF--EGKPILKIEKEGLTAMANAAFRDVSFLLRRSHNEQVAKILS 75
Cdd:PTZ00226 25 VNPEFNFVPIFQPvdPHDTEEYRRLEDlsDYVEVVEVggGGKEILKVPPEALTKLTSYAFSDIQHFLRKSHLAQLRRILD 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 76 DPEASDNDKYVALTFLRNAEVSAKGKLPLCQDTGTAIIHGEKGQQVWTGYCDEEALSLGVYKTYTEENLRYSQNAPLTMY 155
Cdd:PTZ00226 105 DPEASDNDRFVAMTLLKNACIAAGRVLPGCQDTGTAIVLGKRGELIWTGGEDEKALSKGVYNAYTNRNLRYSQLAPLDMF 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 156 DEVNTKCNLPAQIDLEATEGMEYKFLCVTKGGGSANKTYLYQETKAVLNPATLVPFLVEKMKTLGTAACPPYHIAFVIGG 235
Cdd:PTZ00226 185 DEKNTGCNLPAQIDLYATPGNEYEFLFIAKGGGSANKTFLYQQTKSLLNPKSLRKFLEEKIKTIGTSACPPYHLAVVIGG 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 236 TSAEKNLLTVKLASTHYYDELPTTGNEYGRAFRDVELEKQVLEEAYKIGLGAQFGGKYMAHDVRIIRLPRHGASCPIGLG 315
Cdd:PTZ00226 265 LSAEMTLKTVKLASCRYYDSLPTSGDEYGRAFRDLEWEEIILEKTQNIGIGAQFGGKYFAHDVRVIRLPRHGASCPIGIG 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 316 VSCSADRNIKCKINKDGIWIEKMDDKPGELIPaELREA--GEGDVVKIDLNQPMADILKELTKYPVATRLSLNGTIIVGR 393
Cdd:PTZ00226 345 VSCSADRQILAKINKDGVYLEQLEHDPAQYLP-DITEDdlSKTPVVKIDLNQPMEEILKQLSKYPVKTRLSLTGTLIVAR 423
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 394 DIAHAKLKERLDRGEDLPQYIKDHPIYYAGPAKTPEGMACGSMGPTTAGRMDPYVDLFQSHGGSMIMLAKGNRSQQVTDA 473
Cdd:PTZ00226 424 DIAHAKIVEMLENGEPLPEYMKNHPIYYAGPAKTPDGYASGSFGPTTAGRMDSYVDLFMENGGSFITLAKGNRSKAVTNA 503
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 492423503 474 CKKYGGFYLGSIGGPAAILAQNNIKSIECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFKQLKP 540
Cdd:PTZ00226 504 CKKYGGFYLGSIGGPAAILAKDNIKKVEVLDFPELGMEAVWKIEVENFPAFIVVDDKGNDFYSQWLG 570
|
|
| PRK15390 |
PRK15390 |
fumarate hydratase FumA; Provisional |
1-546 |
0e+00 |
|
fumarate hydratase FumA; Provisional
Pssm-ID: 185288 [Multi-domain] Cd Length: 548 Bit Score: 934.45 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 1 MATPPFHYQHMFPLGPDKTEYYLLTKDYVSVSEFEGKPILKIEKEGLTAMANAAFRDVSFLLRRSHNEQVAKILSDPEAS 80
Cdd:PRK15390 1 MSNKPFHYQAPFPLKKDDTEYYLLTSEHVSVSEFEGQEILKVAPEALTLLARQAFHDASFMLRPAHQQQVADILRDPEAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 81 DNDKYVALTFLRNAEVSAKGKLPLCQDTGTAIIHGEKGQQVWTGYCDEEALSLGVYKTYTEENLRYSQNAPLTMYDEVNT 160
Cdd:PRK15390 81 ENDKYVALQFLRNSDIAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGDEAALARGVYNTYIEDNLRYSQNAPLDMYKEVNT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 161 KCNLPAQIDLEATEGMEYKFLCVTKGGGSANKTYLYQETKAVLNPATLVPFLVEKMKTLGTAACPPYHIAFVIGGTSAEK 240
Cdd:PRK15390 161 GTNLPAQIDLYAVDGDEYKFLCIAKGGGSANKTYLYQETKALLTPGKLKNYLVEKMRTLGTAACPPYHIAFVIGGTSAET 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 241 NLLTVKLASTHYYDELPTTGNEYGRAFRDVELEKQVLEEAYKIGLGAQFGGKYMAHDVRIIRLPRHGASCPIGLGVSCSA 320
Cdd:PRK15390 241 NLKTVKLASAKYYDELPTEGNEHGQAFRDVELEKELLIEAQNLGLGAQFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 321 DRNIKCKINKDGIWIEKMDDKPGELIPAELREAGEGDVVKIDLNQPMADILKELTKYPVATRLSLNGTIIVGRDIAHAKL 400
Cdd:PRK15390 321 DRNIKAKINRQGIWIEKLEHNPGKYIPEELRKAGEGEAVRVDLNRPMKEILAQLSQYPVSTRLSLNGTIIVGRDIAHAKL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 401 KERLDRGEDLPQYIKDHPIYYAGPAKTPEGMACGSMGPTTAGRMDPYVDLFQSHGGSMIMLAKGNRSQQVTDACKKYGGF 480
Cdd:PRK15390 401 KERMDNGEGLPQYIKDHPIYYAGPAKTPEGYASGSLGPTTAGRMDSYVDQLQAQGGSMIMLAKGNRSQQVTDACKKHGGF 480
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 492423503 481 YLGSIGGPAAILAQNNIKSIECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFKQLKPRCLGNC 546
Cdd:PRK15390 481 YLGSIGGPAAVLAQGSIKSLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIQLTQCTRC 546
|
|
| PLN00133 |
PLN00133 |
class I-fumerate hydratase; Provisional |
2-537 |
0e+00 |
|
class I-fumerate hydratase; Provisional
Pssm-ID: 215068 [Multi-domain] Cd Length: 576 Bit Score: 879.98 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 2 ATPPFHYQHMFPLGPDKT-EYYLLTKDYVSVSEFEGKPILKIEKEGLTAMANAAFRDVSFLLRRSHNEQVAKILSDPEAS 80
Cdd:PLN00133 37 ASPAFDYQPLFDSNAKKTvPWRKLTGDHVSVVEAAGEKYLKVAPEALTLLSDTAMRDVAHLLRPGHLQQLRNILDDPEAS 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 81 DNDKYVALTFLRNAEVSAKGKLPLCQDTGTAIIHGEKGQQVWTGYCDEEALSLGVYKTYTEENLRYSQNAPLTMYDEVNT 160
Cdd:PLN00133 117 DNDRFVALELLKNANIAAGRVLPGCQDTGTAIVMGKRGQRVLTDGEDEEHLSRGVYDAYTDTNLRYSQVAPLDMFEEKNT 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 161 KCNLPAQIDLEATEGMEYKFLCVTKGGGSANKTYLYQETKAVLNPATLVPFLVEKMKTLGTAACPPYHIAFVIGGTSAEK 240
Cdd:PLN00133 197 GTNLPAQIDLYAAKGDEYHFQFIAKGGGSANKTFLYQQTKALLNEGSLEAFLEEKIKTIGTSACPPYHLAIVIGGLSAEQ 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 241 NLLTVKLASTHYYDELPTTGNEYGRAFRDVELEKQVLEEAYKIGLGAQFGGKYMAHDVRIIRLPRHGASCPIGLGVSCSA 320
Cdd:PLN00133 277 NLKTVKLASTRYYDTLPTSGNALGRAFRDLEWEEKILKMTRGLGIGAQFGGKYFCHDVRVIRLPRHGASCPVGIGVSCSA 356
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 321 DRNIKCKINKDGIWIEKMDDKPGELIPAELREAGEGDVVKIDLNQPMADILKELTKYPVATRLSLNGTIIVGRDIAHAKL 400
Cdd:PLN00133 357 DRQALGKITKDGVFLEALETDPSKYLPDVTEDSLSDDVVKVDLNRPMSEIRETLSAHPVRTRLSLTGTLVVARDIAHAKL 436
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 401 KERLDRGEDLPQYIKDHPIYYAGPAKTPEGMACGSMGPTTAGRMDPYVDLFQSHGGSMIMLAKGNRSQQVTDACKKYGGF 480
Cdd:PLN00133 437 LERLEAGEGLPQYAKDHIIYYAGPAKTPEGYASGSFGPTTAGRMDSYVDRFMAAGGSFVTLAKGNRSAQVTNACKKHGGF 516
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*..
gi 492423503 481 YLGSIGGPAAILAQNNIKSIECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFKQ 537
Cdd:PLN00133 517 YLGSIGGPAAILAQNCIKKVEVLENPELGMEAVWKIEVEDFPAFIVVDDKGNDFFKK 573
|
|
| PRK15392 |
PRK15392 |
class I fumarate hydratase; |
5-542 |
0e+00 |
|
class I fumarate hydratase;
Pssm-ID: 185290 [Multi-domain] Cd Length: 550 Bit Score: 838.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 5 PFHYQHMFPLGPDKTEYYLLTKDYVSVSEFEGKPILKIEKEGLTAMANAAFRDVSFLLRRSHNEQVAKILSDPEASDNDK 84
Cdd:PRK15392 4 PFIWQEPFLQNKDGTEYTLISDQHITVTELDGEEVIKIAPEALTLLARQAFYEASFFLRSAHLQQVASILNDPQASSNDK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 85 YVALTFLRNAEVSAKGKLPLCQDTGTAIIHGEKGQQVWTGYCDEEALSLGVYKTYTEENLRYSQNAPLTMYDEVNTKCNL 164
Cdd:PRK15392 84 YVALQLLRNAEVSAKGVLPNCQDTGTATIVASKGQQIWTGGNDAEALSKGIYSTFQENNLRFSQNAPLDMYTEVNTQTNL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 165 PAQIDLEATEGMEYKFLCVTKGGGSANKTYLYQETKAVLNPATLVPFLVEKMKTLGTAACPPYHIAFVIGGTSAEKNLLT 244
Cdd:PRK15392 164 PAQIDISAVAGDEYHFLCVNKGGGSANKAALYQETKSLLQPEKLTAFLIEKMKSLGTAACPPYHIAFVVGGLSADQTLKV 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 245 VKLASTHYYDELPTTGNEYGRAFRDVELEKQVLEEAYKIGLGAQFGGKYMAHDVRIIRLPRHGASCPIGLGVSCSADRNI 324
Cdd:PRK15392 244 AKLASTKYYDNLPTSGNEQGQAFRDIELEKVLLEASQQFGIGAQFGGKYFAHDIRVIRLPRHGGSCPIAMALSCSADRNI 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 325 KCKINKDGIWIEKMDDKPGELIPAELREAGEGDVVKIDLNQPMADILKELTKYPVATRLSLNGTIIVGRDIAHAKLKERL 404
Cdd:PRK15392 324 KAKINKHGIWLEKLEHNPGQYIPASLREENHAQHVQLDLNRPLRDVMQDLARLPVGTRVSLSGPIVVARDIAHAKIKARL 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 405 DRGEDLPQYIKDHPIYYAGPAKTPEGMACGSMGPTTAGRMDPYVDLFQSHGGSMIMLAKGNRSQQVTDACKKYGGFYLGS 484
Cdd:PRK15392 404 DSGEPMPEYLKHHIVYYAGPAKTPENMACGSLGPTTGGRMDGYVDTFQAAGGSLVMLSKGNRSQQVTDACHKHGGFNLGS 483
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*...
gi 492423503 485 IGGPAAILAQNNIKSIECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFKQLKPRC 542
Cdd:PRK15392 484 IGGAAALLAQEYVKSLRCLEYPELGMEAVWMMEVENLPAFILVDDKGNNFFSQFEQQH 541
|
|
| Fumerase_C |
pfam05683 |
Fumarase C-terminus; This family consists of the C terminal region of several bacterial ... |
332-537 |
2.67e-129 |
|
Fumarase C-terminus; This family consists of the C terminal region of several bacterial fumarate hydratase proteins (FumA and FumB). Fumarase, or fumarate hydratase (EC 4.2.1.2), is a component of the citric acid cycle. In facultative anaerobes such as Escherichia coli, fumarase also engages in the reductive pathway from oxaloacetate to succinate during anaerobic growth.
Pssm-ID: 461714 [Multi-domain] Cd Length: 204 Bit Score: 375.66 E-value: 2.67e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 332 GIWIEKMDDKPGELIPaELREAGEGDVVKIDLNQPmaDILKELTKYPVATRLSLNGTIIVGRDIAHAKLKERLDRGEDLP 411
Cdd:pfam05683 1 GSGPEQLEPPPLEYWP-EWEEDDLAEAVRVDLNRP--ETREELSKWPVGTRLLLSGTLLTGRDAAHKRIKEMLDKGEPLP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 412 QYIKD--HPIYYAGPAKTPEGMACGSMGPTTAGRMDPYVDLFQSHGGSMIMLAKGNRSQQVTDACKKYGGFYLGSIGGpA 489
Cdd:pfam05683 78 EYVDLngRPIYYAGPVDTPGGEVVGSAGPTTATRMDKYVDDFLEKGGSMGMIGKGNRGPAVTEACKKHGGFYLGAIGG-A 156
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 492423503 490 AILAQNNIKSIECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFKQ 537
Cdd:pfam05683 157 AYLAAKAIKKVEVVAFEELGMEAIWEFEVEDFPAFVAVDDKGNSFHKT 204
|
|
| TtdA |
COG1951 |
Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy ... |
41-334 |
1.20e-127 |
|
Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 441554 Cd Length: 289 Bit Score: 374.80 E-value: 1.20e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 41 KIEKEGLTAMANAAFRDVSFLLRRSHNEQVAKILSDpEASDNDKYVALTFLRNAEVSAKGKLPLCQDTGTAIIHGEKGQQ 120
Cdd:COG1951 3 EIDPEDLTEAVAELIIEASYYLPPDVLEALKEALEK-EESPNAKDVLAQILENAEIAAEGKLPICQDTGTAVVFVKIGQD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 121 VWTGYCDEEALSLGVYKTYTEENLRYSQNAPLTmydEVNTKCNLPAQIDLEATEGMEYKFLCVTKGGGSANKTYLYqetk 200
Cdd:COG1951 82 VPIDGDLEEAINEGVRRAYKEGPLRKSVVDPLT---RKNTGDNTPAVIHIEIVPGDKLEITVAPKGGGSENKSALK---- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 201 aVLNPAT----LVPFLVEKMKTLGTAACPPYHIAFVIGGTsAEKNLLTVKLASTHYYDELPttgneygRAFRDVELEKQV 276
Cdd:COG1951 155 -MLNPSEglegVKKFVLETVKEAGGNPCPPGIVGVGIGGT-AEKAAKLAKKALLRPLDERN-------PDPRLAELEEEL 225
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 492423503 277 LEEAYKIGLGAQ-FGGKYMAHDVRIIRLPRHGASCPIGLGVSCSADRNIKCKINKDGIW 334
Cdd:COG1951 226 LEAINKLGIGPQgLGGKTTALDVKIERAPRHIASLPVAVNINCWATRHATAVIDGDGPF 284
|
|
| Fumerase |
pfam05681 |
Fumarate hydratase (Fumerase); This family consists of several bacterial fumarate hydratase ... |
54-324 |
5.98e-108 |
|
Fumarate hydratase (Fumerase); This family consists of several bacterial fumarate hydratase proteins FumA and FumB. Fumarase, or fumarate hydratase (EC 4.2.1.2), is a component of the citric acid cycle. In facultative anaerobes such as Escherichia coli, fumarase also engages in the reductive pathway from oxaloacetate to succinate during anaerobic growth. Three fumarases, FumA, FumB, and FumC, have been reported in E. coli. fumA and fumB genes are homologous and encode products of identical sizes which form thermolabile dimers of Mr 120,000. FumA and FumB are class I enzymes and are members of the iron-dependent hydrolases, which include aconitase and malate hydratase. The active FumA contains a 4Fe-4S centre, and it can be inactivated upon oxidation to give a 3Fe-4S centre.
Pssm-ID: 461713 Cd Length: 267 Bit Score: 323.60 E-value: 5.98e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 54 AFRDVSFLLRRSHNEQVAKILSDpEASDNDKYVALTFLRNAEVSAKGKLPLCQDTGTAIIHGEKGQQVWTGYCD-EEALS 132
Cdd:pfam05681 7 LIIEASTYLPPDVLEALKKALEK-EESPNAKFVLEQILENAEIAAEEKLPICQDTGMAVVFVKIGQDVHIEGGDlEEAIN 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 133 LGVYKTYTEENLRYSQNAPLtmYDEVNTKCNLPAQIDLEATEGMEYKFLCVTKGGGSANKTYLYqetkaVLNPAT----L 208
Cdd:pfam05681 86 EGVRRAYTEGPLRKSVVADP--LTRKNTGDNTPAVIHIEIVPGDELKITVAPKGGGSENMSALK-----MLNPADglegV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 209 VPFLVEKMKTLGTAACPPYHIAFVIGGTSAEKNLLTVKlASthyYDELPTTG-NEYGRafrdvELEKQVLEEAYKIGLGA 287
Cdd:pfam05681 159 KKFVLETVKEAGPNACPPYIVGVGIGGTFEKAALLAKK-AL---LRPLGTRNpDPRGA-----ELEEELLEAINKLGIGP 229
|
250 260 270
....*....|....*....|....*....|....*...
gi 492423503 288 Q-FGGKYMAHDVRIIRLPRHGASCPIGLGVSCSADRNI 324
Cdd:pfam05681 230 QgLGGKTTALDVHIERAPTHIASLPVAVNVQCWADRHA 267
|
|
| FumA |
COG1838 |
Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy ... |
361-547 |
1.16e-100 |
|
Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 441443 Cd Length: 190 Bit Score: 301.64 E-value: 1.16e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 361 IDLNQPMADIlkELTKYPVATRLSLNGTIIVGRDIAHAKLKERLDRGEDLPQYIKDHPIYYAGPAKTPEGMACGSMGPTT 440
Cdd:COG1838 4 IRLNTPLTEE--DVRKLKAGDRVLLSGTIYTARDAAHKRLVELLDRGEPLPVDLKGQVIYYVGPAPAKPGYVIGSAGPTT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 441 AGRMDPYVDLFQSHGGSMIMLAKGNRSQQVTDACKKYGGFYLGSIGGPAAILAQnNIKSIECVEYPELGMEAIWKIEVED 520
Cdd:COG1838 82 STRMDKYTPELLEELGLKGMIGKGGRSPEVIEAMKKHGAVYLAAVGGAAALLAK-AIKKVEVVAYEDLGPEAIWKLEVED 160
|
170 180
....*....|....*....|....*..
gi 492423503 521 FPAFILVDDKGNDFFKQLKPRCLGNCK 547
Cdd:COG1838 161 FPLIVAIDSKGNSLYEQGRAKARARLA 187
|
|
| ttdB_fumA_fumB |
TIGR00723 |
hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region; A number of Fe-S ... |
372-537 |
9.96e-79 |
|
hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region; A number of Fe-S cluster-containing hydro-lyases share a conserved motif, including argininosuccinate lyase, adenylosuccinate lyase, aspartase, class I fumarate hydratase (fumarase), and tartrate dehydratase (see PROSITE:PDOC00147). This model represents a subset of closely related proteins or modules, including the E. coli tartrate dehydratase beta chain and the C-terminal region of the class I fumarase (where the N-terminal region is homologous to the tartrate dehydratase alpha chain). The activity of archaeal proteins in this subfamily has not been established.
Pssm-ID: 129806 Cd Length: 168 Bit Score: 244.65 E-value: 9.96e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 372 KELTKYPVATRLSLNGTIIVGRDIAHAKLKERLDRGEDLPQYIKDHPIYYAGPAKTPEGMA-CGSMGPTTAGRMDPYVDL 450
Cdd:TIGR00723 1 EQILKLKVGDVVYLTGTIFTARDEAHARLLELIDEGKELPFDLNGSVIYHAGPIVTKNGEWeVVSVGPTTSARMNPFEPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 451 FQSHGGSMIMLAKGNRSQQVTDACKKYGGFYLGSIGGPAAILAQnNIKSIECVEYPELGM-EAIWKIEVEDF-PAFILVD 528
Cdd:TIGR00723 81 LLEKLGVMAIIGKGGMSKEVVEACRKYKAVYLAFPGGCAALLAQ-SVKKVEGVAWEDLGMpEAIWELEVEDFgPLIVAID 159
|
....*....
gi 492423503 529 DKGNDFFKQ 537
Cdd:TIGR00723 160 SHGNSIFQE 168
|
|
| PRK06842 |
PRK06842 |
Fe-S-containing hydro-lyase; |
385-536 |
5.40e-45 |
|
Fe-S-containing hydro-lyase;
Pssm-ID: 180724 [Multi-domain] Cd Length: 185 Bit Score: 156.87 E-value: 5.40e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 385 LNGTIIVGRDIAHAKLKERLDRGEDLPQYIKDHPIYYAGPAKTPEGMACGSMGPTTAGRMDPY----VDLfqshgGSMIM 460
Cdd:PRK06842 25 ISGYIYTARDAAHKRLIELLDKGEELPIDIKDQIIYYVGPSPAKPGKVIGSAGPTTSYRMDAYaprlLDI-----GLKGM 99
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 492423503 461 LAKGNRSQQVTDACKKYGGFYLGSIGGPAAILAQnNIKSIECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFK 536
Cdd:PRK06842 100 IGKGARSDEVIESIKKNKAVYFGAIGGAAALIAK-SIKKSEVIAYEDLGAEAIRKLEVKDFPVVVIIDSEGNNLYE 174
|
|
| PRK06246 |
PRK06246 |
fumarate hydratase; Provisional |
78-322 |
4.13e-33 |
|
fumarate hydratase; Provisional
Pssm-ID: 180486 Cd Length: 280 Bit Score: 127.59 E-value: 4.13e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 78 EASDNDKYVALTFLRNAEVSAKGKLPLCQDTGTAIIHGEKGQQV-WTGYCDEEALSLGVYKTYTEENLRYSQ-NAPLTmy 155
Cdd:PRK06246 39 EESPIGKEILKAILENAEIAKEEQVPLCQDTGMAVVFVEIGQDVhIEGGDLEDAINEGVRKGYEEGYLRKSVvADPLT-- 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 156 dEVNTKCNLPAQIDLEATEGMEYKFLCVTKGGGSANKTYLyqetkAVLNPATLVP----FLVEKMKTLGTAACPPYHIAF 231
Cdd:PRK06246 117 -RKNTGDNTPAVIHTEIVPGDKLKITVAPKGGGSENMSAL-----KMLKPADGLEgikkFVLETVKEAGGNPCPPIIVGV 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 232 VIGGTsAEKNLLTVKLAsthyydelpttgneygrAFRDV----------ELEKQVLEEAYKIGLGAQ-FGGKYMAHDVRI 300
Cdd:PRK06246 191 GIGGT-FDKAAKLAKKA-----------------LLRPIgernpdpeiaALEEELLEEINKLGIGPMgLGGKTTALDVKI 252
|
250 260
....*....|....*....|..
gi 492423503 301 IRLPRHGASCPIGLGVSCSADR 322
Cdd:PRK06246 253 ETYPCHIASLPVAVNIQCHAAR 274
|
|
| ttdA_fumA_fumB |
TIGR00722 |
hydro-lyases, Fe-S type, tartrate/fumarate subfamily, alpha region; A number of Fe-S ... |
47-322 |
7.45e-32 |
|
hydro-lyases, Fe-S type, tartrate/fumarate subfamily, alpha region; A number of Fe-S cluster-containing hydro-lyases share a conserved motif, including argininosuccinate lyase, adenylosuccinate lyase, aspartase, class I fumarate hydratase (fumarase), and tartrate dehydratase (see PROSITE:PDOC00147). This model represents a subset of closely related proteins or modules, including the E. coli tartrate dehydratase alpha chain and the N-terminal region of the class I fumarase (where the C-terminal region is homologous to the tartrate dehydratase beta chain). The activity of archaeal proteins in this subfamily has not been established.
Pssm-ID: 273234 Cd Length: 273 Bit Score: 124.11 E-value: 7.45e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 47 LTAMANAAF-RDVSFLLRRSHneqvakilsDPEASDNDKYVALTFLRNAEVSAKGKLPLCQDTGTAIIHGEKGQQVWTGY 125
Cdd:TIGR00722 8 AIKEAVTRLpEDVVDAIKEAY---------DREESEIAKINLEAILDNIEIAEKLGVPVCQDTGVPIFFVKVGSRFVLIG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 126 CDEEALSLGVYKTYTEENLRYSQNAPLtmyDEVNTKCNL---PAQIDLEATEGMEYKFLCVTKGGGSANKTYLyqetkAV 202
Cdd:TIGR00722 79 KLYEAIKQGVEEATEEVPLRPNAVHPL---TRENTGDNTglgVPQIHVEIVPGDELEIVVFPKGAGSENPSAL-----KM 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 203 LNPAT----LVPFLVEKMKTLGTAACPPYHIAFVIGGTS------AEKNLLTvKLASTHYYDELpttgneygrafrdVEL 272
Cdd:TIGR00722 151 LKPSDgiegVKKFVLETVKNAGGKPCPPIIVGVGIGGSFetaaklAKKALLR-PIGERHPNPKI-------------AKL 216
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 492423503 273 EKQVLEEAYKIGLGAQ-FGGKYMAHDVRIIRLPRHGASCPIGLGVSCSADR 322
Cdd:TIGR00722 217 ELELLEEINSLGIGPMgLGGKTTALDVKIESAHCHTASLPVAVNIQCWAHR 267
|
|
| PRK06043 |
PRK06043 |
fumarate hydratase; Provisional |
385-541 |
9.74e-26 |
|
fumarate hydratase; Provisional
Pssm-ID: 180366 Cd Length: 192 Bit Score: 104.46 E-value: 9.74e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 385 LNGTIIVGRDIAHAKLKERLDRGEDLPQYIKDHPIYYAGP--AKTPEGMACGSMGPTTAGRMDPYVDLFQSHGGSMIMLA 462
Cdd:PRK06043 25 ISGEILTARDEAHARILEMKEKGKELPFSLEGAVIYHCGPlmKKTDEGWKVVSAGPTTSARMSKMTPKLLEKVEVRAIIG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 463 KGNRsQQVTDACKKyGGFYLGSIGGPAAiLAQNNIKSIECVEYPELGM-EAIWKIEVEDF-PAFILVDDKGNDFFKQLKP 540
Cdd:PRK06043 105 KGGM-KNVADALKG-KCVYLAYTGGCAA-LAAESIKRVKAVHWLDLGMpEAVWVLEVEEFgPLIVGIDAKGNDLYSEVRE 181
|
.
gi 492423503 541 R 541
Cdd:PRK06043 182 K 182
|
|
| PRK08228 |
PRK08228 |
L(+)-tartrate dehydratase subunit beta; Validated |
385-539 |
9.22e-24 |
|
L(+)-tartrate dehydratase subunit beta; Validated
Pssm-ID: 236192 Cd Length: 204 Bit Score: 98.98 E-value: 9.22e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 385 LNGTIIVGRDIAHAKLKERldrGEDLPQYIKDHPIYYAGP----AKTPEGMACGSMGPTTAGRMDPYVDLFQSHGGSMIM 460
Cdd:PRK08228 26 LTGTLVTCRDVAHRRLIEL---GRELPVDLNGGAIFHAGPivrpKKNDDKFEMVSVGPTTSMRMEKFEKEFIEQTGVKLI 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 461 LAKGNRSQQVTDACKKYGGFYLGSIGGpAAILAQNNIKSIECVEYPELGM-EAIWKIEVEDF-PAFILVDDKGNDFFKQL 538
Cdd:PRK08228 103 VGKGGMGPGTEEGCQEFKALHCVFPAG-CAVLAATQVEEIEDAQWRDLGMpETLWVCRVKEFgPLIVSIDTHGNNLFEEN 181
|
.
gi 492423503 539 K 539
Cdd:PRK08228 182 K 182
|
|
| PRK08395 |
PRK08395 |
fumarate hydratase; Provisional |
361-536 |
9.73e-17 |
|
fumarate hydratase; Provisional
Pssm-ID: 169425 Cd Length: 162 Bit Score: 77.54 E-value: 9.73e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 361 IDLNQPMAdiLKELTKYPVATRLSLNGTIIVGRDIAHAKLKErldrgEDLPQYIKDHPIYYAGPAKTPEGMAcgSMGPTT 440
Cdd:PRK08395 1 VKLKTPLS--WEDVLKLKAGDVVYLSGIIYTARDLAHRRFLS-----EGFPFNPEGAVIYHCGPLVKNKKIV--SAGPTT 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 441 AGRMDPYVDLFQSHGGSMImLAKGNRSQQvtdackKYGG--FYLGSIGGpAAILAQNNIKSIECVEYPELGM-EAIWKIE 517
Cdd:PRK08395 72 SARMNKYLDFLFSLGVRGI-IGKGGMNAE------PFKGraVYFAFPGG-AGSLAAKSIKRVRDVYWEDLGMpDAVWELE 143
|
170
....*....|....*....
gi 492423503 518 VEDFPAFILVDDKGNDFFK 536
Cdd:PRK08395 144 VEDFPLLVAIDSKGRSLYR 162
|
|
| PRK08230 |
PRK08230 |
tartrate dehydratase subunit alpha; Validated |
74-331 |
1.23e-08 |
|
tartrate dehydratase subunit alpha; Validated
Pssm-ID: 181309 Cd Length: 299 Bit Score: 56.64 E-value: 1.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 74 LSDPEASDNDKYVALTFLRNAEVSAKGKLPLCQDTGTAIIHGEKGQQVwtGYCDE--EALSLGVYKTYTEENLRYsqNAP 151
Cdd:PRK08230 36 LKDAETSPLAKIIYDTMFENQQLAIDLNRPSCQDTGVIQFFVKVGARF--PLLGEleSILKEAVEEATVKAPLRH--NAV 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 152 LTmYDEVNTKCNLPAQI---DLEATEGMEYKFLCVTKGGGSANktyLYQETKaVLNPAT----LVPFLVEKMKTLGTAAC 224
Cdd:PRK08230 112 ET-FDEYNTGKNTGSGVpwvFWEIVPDSDDAEIEVYMAGGGCT---LPGRAK-VLMPGEgyegVVKFVFDVITSYGVNAC 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492423503 225 PPYHIAFVIGgTSAEKNLLTVKLA------STHyydelpttGNEygrafRDVELEKqVLEEAY-KIGLGAQ-FGGKYMAH 296
Cdd:PRK08230 187 PPLLVGVGIA-TSVETAAVLSKKAilrpigSRN--------PNP-----RAAELEK-RLEEGLnRIGLGPQgLTGNSSVM 251
|
250 260 270
....*....|....*....|....*....|....*
gi 492423503 297 DVRIIRLPRHGASCPIGLGVSCSADRNIKCKINKD 331
Cdd:PRK08230 252 GVNIESAARHPSTIGVAVSTGCWAHRRGTIVFDAD 286
|
|
| |
