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Conserved domains on  [gi|492406131|ref|WP_005834370|]
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MULTISPECIES: tetratricopeptide repeat protein [Bacteroides]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 708416)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Spy super family cl27809
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 297-474 2.61e-15

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG3914:

Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 78.88  E-value: 2.61e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131 297 YQDPEQREQEIKNISSVYKTLADEILPQLRRSRLTLNYEIIGKSDEEIANLADSDAKQLNIEELLYATtltKDAAKQEAI 376
Cdd:COG3914   24 AELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQAL---GRYEEALAL 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131 377 FTKATQIYPNDFRAYNNLGKLAYQAGDLDKAESYFKKALSIK-DAPEANMNLGLIALTKGDRTAAESYLSKA----SGSK 451
Cdd:COG3914  101 YRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNpDFAEAYLNLGEALRRLGRLEEAIAALRRAleldPDNA 180

                        170       180
                 ....*....|....*....|...
gi 492406131 452 ELNEALGNLYVAQGQYDKAVSSF 474
Cdd:COG3914  181 EALNNLGNALQDLGRLEEAIAAY 203
 
Name Accession Description Interval E-value
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 297-474 2.61e-15

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 78.88  E-value: 2.61e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131 297 YQDPEQREQEIKNISSVYKTLADEILPQLRRSRLTLNYEIIGKSDEEIANLADSDAKQLNIEELLYATtltKDAAKQEAI 376
Cdd:COG3914   24 AELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQAL---GRYEEALAL 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131 377 FTKATQIYPNDFRAYNNLGKLAYQAGDLDKAESYFKKALSIK-DAPEANMNLGLIALTKGDRTAAESYLSKA----SGSK 451
Cdd:COG3914  101 YRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNpDFAEAYLNLGEALRRLGRLEEAIAALRRAleldPDNA 180

                        170       180
                 ....*....|....*....|...
gi 492406131 452 ELNEALGNLYVAQGQYDKAVSSF 474
Cdd:COG3914  181 EALNNLGNALQDLGRLEEAIAAY 203
type_IV_pilW TIGR02521
type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF ...
 367-470 4.06e-10

type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF and PilW. This outer membrane protein is required both for pilus stability and for pilus function such as adherence to human cells. Members of this family contain copies of the TPR (tetratricopeptide repeat) domain.


Pssm-ID: 131573 [Multi-domain]  Cd Length: 234  Bit Score: 60.04  E-value: 4.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131  367 TKDAAKQEAIFTKATQIYPNDFRAYNNLGKLAYQAGDLDKAESYFKKALSIKDAPE---ANMNLGLIALTKGDRTAAESY 443
Cdd:TIGR02521  78 LGELEKAEDSFRRALTLNPNNGDVLNNYGTFLCQQGKYEQAMQQFEQAIEDPLYPQparSLENAGLCALKAGDFDKAEKY 157

                          90       100       110
                  ....*....|....*....|....*....|.
gi 492406131  444 LSKA----SGSKELNEALGNLYVAQGQYDKA 470
Cdd:TIGR02521 158 LTRAlqidPQRPESLLELAELYYLRGQYKDA 188
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 393-447 7.26e-05

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 41.17  E-value: 7.26e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 492406131  393 NLGKLAYQAGDLDKAESYFKKAL----SIKDAPEANMNLGLIALTKGDRTAAESYLSKA 447
Cdd:pfam13432   2 ALARAALRAGDYDDAAAALEAALarfpESPDAAAALLLLGLAALRQGRLAEAAAAYRAA 60
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 388-417 1.02e-04

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 39.74  E-value: 1.02e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 492406131   388 FRAYNNLGKLAYQAGDLDKAESYFKKALSI 417
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALEL 30
gliding_GltE NF033758
adventurous gliding motility TPR repeat lipoprotein GltE; GltE (also called AglT) is a ...
 379-488 5.23e-04

adventurous gliding motility TPR repeat lipoprotein GltE; GltE (also called AglT) is a tetratricopeptide repeat protein with a lipoprotein signal peptide and a role in A-motility (adventurous gliding motility) in Myxococcus xanthus and other delta-proteobacteria.


Pssm-ID: 468174 [Multi-domain]  Cd Length: 411  Bit Score: 42.50  E-value: 5.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131 379 KATQIYPNDFRAYNNLGKLAYQAGDLDKAESYFKKALSIK-DAPEANMNLGLIALTKGDRTAAESYLSKASGSKELNEA- 456
Cdd:NF033758 213 RAVKIDQNDPELHHTVGLILLQEGDKDGARLQFKRALEVRaDYVPSHVELAQLALDAEDYPGAEEHLRRILQADGKNAAa 292

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 492406131 457 ---LGNLYVAQGQYDKAVSSFGDTKTNSAALAQIL 488
Cdd:NF033758 293 hlnLGVAYKGQGQYDKAMQEYDEAEKLDPELAAIY 327
 
Name Accession Description Interval E-value
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 297-474 2.61e-15

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 78.88  E-value: 2.61e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131 297 YQDPEQREQEIKNISSVYKTLADEILPQLRRSRLTLNYEIIGKSDEEIANLADSDAKQLNIEELLYATtltKDAAKQEAI 376
Cdd:COG3914   24 AELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQAL---GRYEEALAL 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131 377 FTKATQIYPNDFRAYNNLGKLAYQAGDLDKAESYFKKALSIK-DAPEANMNLGLIALTKGDRTAAESYLSKA----SGSK 451
Cdd:COG3914  101 YRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNpDFAEAYLNLGEALRRLGRLEEAIAALRRAleldPDNA 180

                        170       180
                 ....*....|....*....|...
gi 492406131 452 ELNEALGNLYVAQGQYDKAVSSF 474
Cdd:COG3914  181 EALNNLGNALQDLGRLEEAIAAY 203
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 368-474 1.57e-14

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 70.61  E-value: 1.57e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131 368 KDAAKQEAIFTKATQIYPNDFRAYNNLGKLAYQAGDLDKAESYFKKALSI-KDAPEANMNLGLIALTKGDRTAAESYLSK 446
Cdd:COG4783   18 GDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELdPDEPEARLNLGLALLKAGDYDEALALLEK 97

                         90       100       110
                 ....*....|....*....|....*....|..
gi 492406131 447 A----SGSKELNEALGNLYVAQGQYDKAVSSF 474
Cdd:COG4783   98 AlkldPEHPEAYLRLARAYRALGRPDEAIAAL 129
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
373-553 9.91e-14

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 71.19  E-value: 9.91e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131 373 QEAI--FTKATQIYPNDFRAYNNLGKLAYQAGDLDKAESYFKKALSIK-DAPEANMNLGLIALTKGDRTAAESYLSKA-- 447
Cdd:COG0457   25 EEAIedYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDpDDAEALNNLGLALQALGRYEEALEDYDKAle 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131 448 --SGSKELNEALGNLYVAQGQYDKAVSSFG---DTKTNSAALAQILAKDYNKAKNTLAAIErpdAYTDYLMAVLGARTNN 522
Cdd:COG0457  105 ldPDDAEALYNLGLALLELGRYDEAIEAYEralELDPDDADALYNLGIALEKLGRYEEALE---LLEKLEAAALAALLAA 181

                        170       180       190
                 ....*....|....*....|....*....|.
gi 492406131 523 TSMVTSSLKNAIAKEPALAKKAASDLEFAKY 553
Cdd:COG0457  182 ALGEAALALAAAEVLLALLLALEQALRKKLA 212
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 317-447 1.53e-13

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 68.45  E-value: 1.53e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131 317 LADEILPQLRRSRLTLNYEIIGKSDEEIANLADSDAKQLNIEELLYATTLTKDAAKQEAIFTKATQIYPNDFRAYNNLGK 396
Cdd:COG5010   17 LTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLAL 96

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 492406131 397 LAYQAGDLDKAESYFKKALSIK-DAPEANMNLGLIALTKGDRTAAESYLSKA 447
Cdd:COG5010   97 LYSRSGDKDEAKEYYEKALALSpDNPNAYSNLAALLLSLGQDDEAKAALQRA 148
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 332-545 1.72e-13

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 70.91  E-value: 1.72e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131 332 LNYEIIGKSD---EEIANLADSDAKqlNIEELLYATTL---TKDAAKQEAIFTKATQIYPNDFRAYNNLGKLAYQAGDLD 405
Cdd:COG2956   16 LNYLLNGQPDkaiDLLEEALELDPE--TVEAHLALGNLyrrRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLD 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131 406 KAESYFKKALSIK-DAPEANMNLGLIALTKGDRTAAESYLSKASGSKELNEA----LGNLYVAQGQYDKAVSSF----GD 476
Cdd:COG2956   94 RAEELLEKLLELDpDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHayceLAELYLEQGDYDEAIEALekalKL 173

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 492406131 477 TKTNSAA---LAQILAK--DYNKAKNTLAAIERPD---AYTDYLMAVLGARTNNTSMVTSSLKNAIAKEPALAKKAA 545
Cdd:COG2956  174 DPDCARAlllLAELYLEqgDYEEAIAALERALEQDpdyLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLA 250
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
382-474 1.45e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 64.64  E-value: 1.45e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131 382 QIYPNDFRAYNNLGKLAYQAGDLDKAESYFKKALSIK-DAPEANMNLGLIALTKGDRTAAESYLSKA----SGSKELNEA 456
Cdd:COG0457    2 ELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDpDDAEALYNLGLAYLRLGRYEEALADYEQAleldPDDAEALNN 81

                         90
                 ....*....|....*...
gi 492406131 457 LGNLYVAQGQYDKAVSSF 474
Cdd:COG0457   82 LGLALQALGRYEEALEDY 99
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
374-447 3.16e-11

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 59.80  E-value: 3.16e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 492406131 374 EAIFTKATQIYPNDFRAYNNLGKLAYQAGDLDKAESyFKKALSIK-DAPEANMNLGLIALTKGDRTAAESYLSKA 447
Cdd:COG3063   12 EEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDpNNAEALLNLAELLLELGDYDEALAYLERA 85
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 389-504 1.67e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 59.05  E-value: 1.67e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131 389 RAYNNLGKLAYQAGDLDKAESYFKKALSI-KDAPEANMNLGLIALTKGDRTAAESYLSKA----SGSKELNEALGNLYVA 463
Cdd:COG4783    5 EALYALAQALLLAGDYDEAEALLEKALELdPDNPEAFALLGEILLQLGDLDEAIVLLHEAleldPDEPEARLNLGLALLK 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 492406131 464 QGQYDKAVSSFG---DTKTNSAALAQILAKDYNKAKNTLAAIER 504
Cdd:COG4783   85 AGDYDEALALLEkalKLDPEHPEAYLRLARAYRALGRPDEAIAA 128
type_IV_pilW TIGR02521
type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF ...
 367-470 4.06e-10

type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF and PilW. This outer membrane protein is required both for pilus stability and for pilus function such as adherence to human cells. Members of this family contain copies of the TPR (tetratricopeptide repeat) domain.


Pssm-ID: 131573 [Multi-domain]  Cd Length: 234  Bit Score: 60.04  E-value: 4.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131  367 TKDAAKQEAIFTKATQIYPNDFRAYNNLGKLAYQAGDLDKAESYFKKALSIKDAPE---ANMNLGLIALTKGDRTAAESY 443
Cdd:TIGR02521  78 LGELEKAEDSFRRALTLNPNNGDVLNNYGTFLCQQGKYEQAMQQFEQAIEDPLYPQparSLENAGLCALKAGDFDKAEKY 157

                          90       100       110
                  ....*....|....*....|....*....|.
gi 492406131  444 LSKA----SGSKELNEALGNLYVAQGQYDKA 470
Cdd:TIGR02521 158 LTRAlqidPQRPESLLELAELYYLRGQYKDA 188
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 361-447 4.12e-10

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 61.46  E-value: 4.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131 361 LYATTLTKDAAKQEAIFTKATQIYPNDFRAYNNLGKLAYQAGDLDKAESYFKKALSIKDAPEANMNLGLIALTKGDRTAA 440
Cdd:COG3071  231 LYGRLQGGDPAKQLKRAEKWLKKHPNDPDLLLALGRLCLRNQLWGKAREYLEAALALRPSAEAYAELARLLEQLGDPEEA 310


                 ....*..
gi 492406131 441 ESYLSKA 447
Cdd:COG3071  311 AEHYRKA 317
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 394-542 1.30e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 59.36  E-value: 1.30e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131 394 LGKLAYQAGDLDKAESYFKKALSI-KDAPEANMNLGLIALTKGDRTAAESYLSKA----SGSKELNEALGNLYVAQGQYD 468
Cdd:COG2956   14 KGLNYLLNGQPDKAIDLLEEALELdPETVEAHLALGNLYRRRGEYDRAIRIHQKLlerdPDRAEALLELAQDYLKAGLLD 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131 469 KAVSSF----GDTKTNSAALAQILA-----KDYNKAKNT---LAAIERPDAYTDYLMAVLGARTNNTSMVTSSLKNAIAK 536
Cdd:COG2956   94 RAEELLekllELDPDDAEALRLLAEiyeqeGDWEKAIEVlerLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKL 173


                 ....*.
gi 492406131 537 EPALAK 542
Cdd:COG2956  174 DPDCAR 179
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 367-447 1.79e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 56.35  E-value: 1.79e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131 367 TKDAAKQEAIFTKATQIYPNDFRAYNNLGKLAYQAGDLDKAESYFKKALSIK-DAPEANMNLGLIALTKGDRTAAESYLS 445
Cdd:COG4783   51 LGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDpEHPEAYLRLARAYRALGRPDEAIAALE 130


                 ..
gi 492406131 446 KA 447
Cdd:COG4783  131 KA 132
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 372-474 1.95e-09

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 55.78  E-value: 1.95e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131 372 KQEAIFTKATQIYPNDFRAYNNLGKLAYQAGDLDKAESYFKKALSIK-DAPEANMNLGLIALTKGDRTAAESYLSKA--- 447
Cdd:COG4235    1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDpDNADALLDLAEALLAAGDTEEAEELLERAlal 80

                         90       100
                 ....*....|....*....|....*...
gi 492406131 448 -SGSKELNEALGNLYVAQGQYDKAVSSF 474
Cdd:COG4235   81 dPDNPEALYLLGLAAFQQGDYAEAIAAW 108
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 323-538 2.52e-09

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 60.10  E-value: 2.52e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131  323 PQLRRSRLTLNYEII--GKSDEEIANLADSDAKQLN---IEELLYATTLTK-DAAKQEAIFTKATQIYPNDFRAYNNLGK 396
Cdd:TIGR02917 428 PELGRADLLLILSYLrsGQFDKALAAAKKLEKKQPDnasLHNLLGAIYLGKgDLAKAREAFEKALSIEPDFFPAAANLAR 507

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131  397 LAYQAGDLDKAESYFKKALSI-KDAPEANMNLGLIALTKGDRTAAESYLSKASG--SKELNEA--LGNLYVAQGQYDKAV 471
Cdd:TIGR02917 508 IDIQEGNPDDAIQRFEKVLTIdPKNLRAILALAGLYLRTGNEEEAVAWLEKAAElnPQEIEPAlaLAQYYLGKGQLKKAL 587

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 492406131  472 S---SFGDTKTNSAAL------AQILAKDYNKAKNT---LAAIERPDAYTDYLMAVLGARTNNTSMVTSSLKNAIAKEP 538
Cdd:TIGR02917 588 AilnEAADAAPDSPEAwlmlgrAQLAAGDLNKAVSSfkkLLALQPDSALALLLLADAYAVMKNYAKAITSLKRALELKP 666
type_IV_pilW TIGR02521
type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF ...
 342-454 3.91e-09

type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF and PilW. This outer membrane protein is required both for pilus stability and for pilus function such as adherence to human cells. Members of this family contain copies of the TPR (tetratricopeptide repeat) domain.


Pssm-ID: 131573 [Multi-domain]  Cd Length: 234  Bit Score: 57.35  E-value: 3.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131  342 EEIANLADSDAKQLNIeellYATTL--TKDAAKQEAIFTKA--TQIYPNDFRAYNNLGKLAYQAGDLDKAESYFKKALSI 417
Cdd:TIGR02521  89 RRALTLNPNNGDVLNN----YGTFLcqQGKYEQAMQQFEQAieDPLYPQPARSLENAGLCALKAGDFDKAEKYLTRALQI 164

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 492406131  418 -KDAPEANMNLGLIALTKGDRTAAESYLSKASGSKELN 454
Cdd:TIGR02521 165 dPQRPESLLELAELYYLRGQYKDARAYLERYQQTYNQT 202
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 341-474 4.46e-09

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 55.74  E-value: 4.46e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131 341 DEEIANLADSDAKQLNIEELLYATTLTKDAAKQEAIFTKATQIYPNDFRAYNNLGKLAYQAGDLDKAESYFKKALSIK-D 419
Cdd:COG5010    7 FDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDpN 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 492406131 420 APEANMNLGLIALTKGDRTAAESYLSKA----SGSKELNEALGNLYVAQGQYDKAVSSF 474
Cdd:COG5010   87 NPELYYNLALLYSRSGDKDEAKEYYEKAlalsPDNPNAYSNLAALLLSLGQDDEAKAAL 145
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
341-503 4.53e-09

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 56.85  E-value: 4.53e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131 341 DEEIANLADSDAKQLNIEELLYATTLTKDAAKQ--EAI--FTKATQIYPNDFRAYNNLGKLAYQAGDLDKAESYFKKALS 416
Cdd:COG4785   56 AALAAERIDRALALPDLAQLYYERGVAYDSLGDydLAIadFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALE 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131 417 IK-DAPEANMNLGLIALTKGDRTAAESYLSKA-SGSKELNEALGNLYVAQGQ--YDKAVssfgdtktnsAALAQILAKDY 492
Cdd:COG4785  136 LDpDYAYAYLNRGIALYYLGRYELAIADLEKAlELDPNDPERALWLYLAERKldPEKAL----------ALLLEDWATAY 205

                        170
                 ....*....|.
gi 492406131 493 NKAKNTLAAIE 503
Cdd:COG4785  206 LLQGDTEEARE 216
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 369-447 6.10e-09

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 54.63  E-value: 6.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131 369 DAAKQEAIFTKATQIYPNDFRAYNNLGKLAYQAGDLDKAESYFKKALSIK-DAPEANMNLGLIALTKGDRTAAESYLSKA 447
Cdd:COG4235   32 RYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDpDNPEALYLLGLAAFQQGDYAEAIAAWQKL 111
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
397-470 7.27e-08

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 50.17  E-value: 7.27e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 492406131 397 LAYQAGDLDKAESYFKKALSIK-DAPEANMNLGLIALTKGDRTAAESY---LSKASGSKELNEALGNLYVAQGQYDKA 470
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDpDNADALNNLGLLLLEQGRYDEAIALekaLKLDPNNAEALLNLAELLLELGDYDEA 78
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 334-510 4.55e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 52.69  E-value: 4.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131 334 YEIIGKSDEEIANL-------ADSDAKQLNIEELLYATTLTKDAakqEAIFTKATQIYPNDFRAYNNLGKLAYQAGDLDK 406
Cdd:COG3914  122 LLALGRLEEALAALrralalnPDFAEAYLNLGEALRRLGRLEEA---IAALRRALELDPDNAEALNNLGNALQDLGRLEE 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131 407 AESYFKKALSIK-DAPEANMNLGLIALTKGDRTAAESYLSKASGSKELNEALGNLYVAqgqydkavSSFGDTKTNSAALA 485
Cdd:COG3914  199 AIAAYRRALELDpDNADAHSNLLFALRQACDWEVYDRFEELLAALARGPSELSPFALL--------YLPDDDPAELLALA 270

                        170       180
                 ....*....|....*....|....*
gi 492406131 486 QILAKDYNKAKNTLAAIERPDAYTD 510
Cdd:COG3914  271 RAWAQLVAAAAAPELPPPPNPRDPD 295
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 367-447 2.00e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 49.73  E-value: 2.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131 367 TKDAAKQEAIFTKATQIYPNDFRAYNNLGKLAYQAGDLDKAESYFKKALSIKDAPEANMNLGLIALTKGDRTAAESYLSK 446
Cdd:COG2956  191 QGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLALADLLERKEGLEAALALLER 270


                 .
gi 492406131 447 A 447
Cdd:COG2956  271 Q 271
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 360-420 3.74e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 46.54  E-value: 3.74e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 492406131 360 LLYATTLTKDAAKQEAI--FTKATQIYPNDFRAYNNLGKLAYQAGDLDKAESYFKKALSIKDA 420
Cdd:COG4235   55 LDLAEALLAAGDTEEAEelLERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPA 117
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 368-446 4.81e-06

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 45.75  E-value: 4.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131 368 KDAAKQEAIFTKATQIYPNDF---RAYNNLGKLAYQAGDLDKAESYFKKALSI----KDAPEANMNLGLIALTKGDRTAA 440
Cdd:COG1729    7 GDYDEAIAAFKAFLKRYPNSPlapDALYWLGEAYYALGDYDEAAEAFEKLLKRypdsPKAPDALLKLGLSYLELGDYDKA 86


                 ....*.
gi 492406131 441 ESYLSK 446
Cdd:COG1729   87 RATLEE 92
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 238-539 4.90e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 49.70  E-value: 4.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131  238 LAENRQDNTAKIINRDLKKAKIDAAVDtkYTAQDWE----GFQELVSKSNIQDKELILRVLSMYQ--DPEQREQEIKNIs 311
Cdd:TIGR02917 245 EAEKHADALLKKAPNSPLAHYLKALVD--FQKKNYEdareTLQDALKSAPEYLPALLLAGASEYQlgNLEQAYQYLNQI- 321

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131  312 svykTLADEILPQLRRSrLTLNYEIIGKSDEEIANL------ADSDAKQLNIeeLLYATTLTKDAAKQEAIFTKATQIYP 385
Cdd:TIGR02917 322 ----LKYAPNSHQARRL-LASIQLRLGRVDEAIATLspalglDPDDPAALSL--LGEAYLALGDFEKAAEYLAKATELDP 394

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131  386 NDFRAYNNLGKLAYQAGDLDKAESYFKKALSIKDAP-EANMNLGLIALTKGD----RTAAESYLSKASGSKELNEALGNL 460
Cdd:TIGR02917 395 ENAAARTQLGISKLSQGDPSEAIADLETAAQLDPELgRADLLLILSYLRSGQfdkaLAAAKKLEKKQPDNASLHNLLGAI 474

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131  461 YVAQGQYDKAVSSFGDT-KTNSAALAQI--LAKDYNKAKNTLAAIERPDAYTDYL---------MAVLGARTNNTSMVTS 528
Cdd:TIGR02917 475 YLGKGDLAKAREAFEKAlSIEPDFFPAAanLARIDIQEGNPDDAIQRFEKVLTIDpknlrailaLAGLYLRTGNEEEAVA 554

                         330
                  ....*....|.
gi 492406131  529 SLKNAIAKEPA 539
Cdd:TIGR02917 555 WLEKAAELNPQ 565
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
362-420 9.75e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 44.39  E-value: 9.75e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131 362 YATTLTKDAAKQEAI-FTKATQIYPNDFRAYNNLGKLAYQAGDLDKAESYFKKALSIKDA 420
Cdd:COG3063   32 LGLLLLEQGRYDEAIaLEKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELDPS 91
TPR_hemY_coli TIGR00540
heme biosynthesis-associated TPR protein; Members of this protein family are uncharacterized ...
 344-447 1.00e-05

heme biosynthesis-associated TPR protein; Members of this protein family are uncharacterized tetratricopeptide repeat (TPR) proteins invariably found in heme biosynthesis gene clusters. The absence of any invariant residues other than Ala argues against this protein serving as an enzyme per se. The gene symbol hemY assigned in E. coli is unfortunate in that an unrelated protein, protoporphyrinogen oxidase (HemG in E. coli) is designated HemY in Bacillus subtilis. [Unknown function, General]


Pssm-ID: 273126 [Multi-domain]  Cd Length: 367  Bit Score: 48.05  E-value: 1.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131  344 IANLADSDAKQLnIEELL-----------YATTLTKDAAKQEAIFTKATQIYPNDFRAYNNLGKLAYQAGDLDKAESYFK 412
Cdd:TIGR00540 254 IQLGDHDEAEKL-IEEALkkewdpellrlYGRLQPGDPSPLIKRAEKWLKKHPDDALLLLALGRLCLRQQLWGKAQSYLE 332

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 492406131  413 KALSIKDAPEANMNLGLIALTKGDRTAAESYLSKA 447
Cdd:TIGR00540 333 ASLSLAPTEEAHLELAQLFEQLGDTEAAAQHYRKS 367
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 395-503 3.82e-05

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 46.06  E-value: 3.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131 395 GKLAYQAGDLDKAESYFKKALSIKDAPEAN-MNLGLIALTKGDRTAAESYLSKASGS-KELNEALG----NLYVAQGQYD 468
Cdd:COG3071   23 GLLALAEGRYARAEKLLSKAAEHSEAPLLAyLLAARAAQALGDYERRDEYLAQALELaPEAELAVLltraELLLDQGQAE 102

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 492406131 469 KAVSSFG---DTKTNSAALAQILAKDYNKAKNTLAAIE 503
Cdd:COG3071  103 QALATLEalrAGAPRHPQVLRLLLQAYRQLGDWEELLE 140
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 287-474 5.99e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 46.23  E-value: 5.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131  287 KELILRVLSMYQDPEQREQEIKNISSVYKTLADEILPQLRrsrLTLNYEIIGKSDEEIANL-------ADSDAKQLNIEE 359
Cdd:TIGR02917 601 PEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALALLL---LADAYAVMKNYAKAITSLkralelkPDNTEAQIGLAQ 677

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131  360 LLYATTLTKDAAKQEAIFTKAtqiYPNDFRAYNNLGKLAYQAGDLDKAESYFKKALSIKDAPEANMNLGLIALTKGDRTA 439
Cdd:TIGR02917 678 LLLAAKRTESAKKIAKSLQKQ---HPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAPSSQNAIKLHRALLASGNTAE 754

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 492406131  440 A----ESYLSKASGSKELNEALGNLYVAQGQYDKAVSSF 474
Cdd:TIGR02917 755 AvktlEAWLKTHPNDAVLRTALAELYLAQKDYDKAIKHY 793
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 393-447 7.26e-05

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 41.17  E-value: 7.26e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 492406131  393 NLGKLAYQAGDLDKAESYFKKAL----SIKDAPEANMNLGLIALTKGDRTAAESYLSKA 447
Cdd:pfam13432   2 ALARAALRAGDYDDAAAALEAALarfpESPDAAAALLLLGLAALRQGRLAEAAAAYRAA 60
TPR_12 pfam13424
Tetratricopeptide repeat;
389-447 7.63e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 41.22  E-value: 7.63e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 492406131  389 RAYNNLGKLAYQAGDLDKAESYFKKALSI------KDAP---EANMNLGLIALTKGDRTAAESYLSKA 447
Cdd:pfam13424   4 TALNNLAAVLRRLGRYDEALELLEKALEIarrllgPDHPltaTTLLNLGRLYLELGRYEEALELLERA 71
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 388-417 1.02e-04

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 39.74  E-value: 1.02e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 492406131   388 FRAYNNLGKLAYQAGDLDKAESYFKKALSI 417
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALEL 30
TPR_1 pfam00515
Tetratricopeptide repeat;
389-417 1.44e-04

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 39.33  E-value: 1.44e-04
                          10        20
                  ....*....|....*....|....*....
gi 492406131  389 RAYNNLGKLAYQAGDLDKAESYFKKALSI 417
Cdd:pfam00515   2 KALYNLGNAYFKLGKYDEALEYYEKALEL 30
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 366-417 2.46e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 41.87  E-value: 2.46e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 492406131 366 LTKDAAKQEAIFTKATQIYPNDFRAYNNLGKLAYQAGDLDKAESYFKKALSI 417
Cdd:COG5010  100 RSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGT 151
YfgM COG2976
Putative negative regulator of RcsB-dependent stress response, UPF0070 family [Signal ...
 394-474 3.15e-04

Putative negative regulator of RcsB-dependent stress response, UPF0070 family [Signal transduction mechanisms];


Pssm-ID: 442215 [Multi-domain]  Cd Length: 207  Bit Score: 42.15  E-value: 3.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131 394 LGKLAYQAGDLDKAESYFKKALSIKDAPE----ANMNLGLIALTKGDRTAAESYLSKASGSK---ELNEALGNLYVAQGQ 466
Cdd:COG2976   96 LAKAAVDAGDLDKAAAQLQWVLDNAKDPAlkalARLRLARVLLAQKKYDEALATLDAVKPEAfaaLYAELRGDILLAQGD 175


                 ....*...
gi 492406131 467 YDKAVSSF 474
Cdd:COG2976  176 KAEARAAY 183
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 388-417 3.59e-04

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 37.89  E-value: 3.59e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 492406131  388 FRAYNNLGKLAYQAGDLDKAESYFKKALSI 417
Cdd:pfam07719   1 AEALYNLGLAYYKLGDYEEALEAYEKALEL 30
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 368-449 4.12e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.53  E-value: 4.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131  368 KDAAKQEAIFTKATQIYPNDFRAYNNLGKLaYQAGDLDKAESYFKKALSIKDAPEANMN-LGLIALTKGDRTAAESYLSK 446
Cdd:TIGR02917 784 KDYDKAIKHYQTVVKKAPDNAVVLNNLAWL-YLELKDPRALEYAERALKLAPNIPAILDtLGWLLVEKGEADRALPLLRK 862


                  ...
gi 492406131  447 ASG 449
Cdd:TIGR02917 863 AVN 865
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 374-517 4.89e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.15  E-value: 4.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131  374 EAIFTKATQIYPNDFRAYNNLGKLAYQAGDLDKAESYFKKALSI-KDAPEANMNLGLIALTKGD----RTAAESYLSKAS 448
Cdd:TIGR02917 213 LAAYRKAIALRPNNIAVLLALATILIEAGEFEEAEKHADALLKKaPNSPLAHYLKALVDFQKKNyedaRETLQDALKSAP 292

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 492406131  449 GSKELNEALGNLYVAQGQYDKAVSSFGDTKTNS---------AALAQILAKDYNKAKNTLAAIERPDAYTDYLMAVLG 517
Cdd:TIGR02917 293 EYLPALLLAGASEYQLGNLEQAYQYLNQILKYApnshqarrlLASIQLRLGRVDEAIATLSPALGLDPDDPAALSLLG 370
gliding_GltE NF033758
adventurous gliding motility TPR repeat lipoprotein GltE; GltE (also called AglT) is a ...
 379-488 5.23e-04

adventurous gliding motility TPR repeat lipoprotein GltE; GltE (also called AglT) is a tetratricopeptide repeat protein with a lipoprotein signal peptide and a role in A-motility (adventurous gliding motility) in Myxococcus xanthus and other delta-proteobacteria.


Pssm-ID: 468174 [Multi-domain]  Cd Length: 411  Bit Score: 42.50  E-value: 5.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131 379 KATQIYPNDFRAYNNLGKLAYQAGDLDKAESYFKKALSIK-DAPEANMNLGLIALTKGDRTAAESYLSKASGSKELNEA- 456
Cdd:NF033758 213 RAVKIDQNDPELHHTVGLILLQEGDKDGARLQFKRALEVRaDYVPSHVELAQLALDAEDYPGAEEHLRRILQADGKNAAa 292

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 492406131 457 ---LGNLYVAQGQYDKAVSSFGDTKTNSAALAQIL 488
Cdd:NF033758 293 hlnLGVAYKGQGQYDKAMQEYDEAEKLDPELAAIY 327
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 368-418 8.98e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 39.79  E-value: 8.98e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 492406131 368 KDAAKQEAIFTKATQIYPNDFRAYNNLGKLAYQAGDLDKAESYFKKALSIK 418
Cdd:COG4783   86 GDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELD 136
TPR_8 pfam13181
Tetratricopeptide repeat;
389-418 1.06e-03

Tetratricopeptide repeat;


Pssm-ID: 404131 [Multi-domain]  Cd Length: 33  Bit Score: 36.61  E-value: 1.06e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 492406131  389 RAYNNLGKLAYQAGDLDKAESYFKKALSIK 418
Cdd:pfam13181   2 EAYYNLGLIYLKLGDYEEAKEYYEKALELD 31
TPR_12 pfam13424
Tetratricopeptide repeat;
368-420 1.46e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 37.75  E-value: 1.46e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 492406131  368 KDAAKQEAIFTKATQIY--------PNDFRAYNNLGKLAYQAGDLDKAESYFKKALSIKDA 420
Cdd:pfam13424  17 GRYDEALELLEKALEIArrllgpdhPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
TPR_17 pfam13431
Tetratricopeptide repeat;
377-408 1.56e-03

Tetratricopeptide repeat;


Pssm-ID: 433201 [Multi-domain]  Cd Length: 34  Bit Score: 36.37  E-value: 1.56e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 492406131  377 FTKATQIYPNDFRAYNNLGKLAYQAGDLDKAE 408
Cdd:pfam13431   2 YLKALELDPNNADAYYNLAVLLLELGQSETAL 33
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
373-470 2.57e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 39.99  E-value: 2.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131 373 QEAI--FTKATQIYPNDFRAYNNLGKLAYQAGDLDKAESYFKKALSIKDAPEANMNLGLIALTKGDRTAAESYLSKASGS 450
Cdd:COG0457  127 DEAIeaYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQA 206

                         90       100
                 ....*....|....*....|
gi 492406131 451 KELNEALGNLYVAQGQYDKA 470
Cdd:COG0457  207 LRKKLAILTLAALAELLLLA 226
TPR_7 pfam13176
Tetratricopeptide repeat;
390-422 2.77e-03

Tetratricopeptide repeat;


Pssm-ID: 433012 [Multi-domain]  Cd Length: 36  Bit Score: 35.59  E-value: 2.77e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 492406131  390 AYNNLGKLAYQAGDLDKAESYFKKALSIKDAPE 422
Cdd:pfam13176   1 ALLNLGRIYRKLGDYDEAISLYEQALALAKDPY 33
TPR_10 pfam13374
Tetratricopeptide repeat;
389-417 3.83e-03

Tetratricopeptide repeat;


Pssm-ID: 463861 [Multi-domain]  Cd Length: 42  Bit Score: 35.17  E-value: 3.83e-03
                          10        20
                  ....*....|....*....|....*....
gi 492406131  389 RAYNNLGKLAYQAGDLDKAESYFKKALSI 417
Cdd:pfam13374   3 SSLNNLANALRAQGRYDEAEELLEEALAI 31
HemYx COG3898
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to HemY-type ...
 398-470 4.66e-03

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to HemY-type protoporphyrinogen oxidase) [Function unknown];


Pssm-ID: 443105 [Multi-domain]  Cd Length: 468  Bit Score: 39.49  E-value: 4.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131 398 AYQAGDLDKAESYFKKALSIKDAPEanmnLGLI-----ALTKGDRTAAESYLSKA----SGSKELNEALGNLYVAQGQYD 468
Cdd:COG3898  128 AQLAGDREAARRAFEAMLEDPETRF----LGLRglmveALRRGDTEAALALAEEAlalaPKLPWAQDALLELQAAAGDWD 203


                 ..
gi 492406131 469 KA 470
Cdd:COG3898  204 GA 205
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 369-415 7.45e-03

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 35.39  E-value: 7.45e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 492406131  369 DAAKQEAIFTKATQIYPNDFRAYNNLGKLAYQAGDLDKAESYFKKAL 415
Cdd:pfam13432  15 DAAAALEAALARFPESPDAAAALLLLGLAALRQGRLAEAAAAYRAAL 61
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 380-504 7.91e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 39.30  E-value: 7.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131  380 ATQIYPNDFRAYNNLGKLAYQAGDLDKAESYFKKALSIKdAPEANMNLGL----IALTKGDRTAAES---YLSKASGSKE 452
Cdd:TIGR02917  48 ALQKDPNDAEARFLLGKIYLALGDYAAAEKELRKALSLG-YPKNQVLPLLarayLLQGKFQQVLDELpgkTLLDDEGAAE 126

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 492406131  453 LNEALGNLYVAQGQYDKAVSSFGDTKTNSA-------ALAQILAkDYNKAKNTLAAIER 504
Cdd:TIGR02917 127 LLALRGLAYLGLGQLELAQKSYEQALAIDPrslyaklGLAQLAL-AENRFDEARALIDE 184
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 318-490 9.04e-03

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 38.35  E-value: 9.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131 318 ADEILPQLRRSRLtlnyeiigksdeeianLADSDAKQLniEELLYATTLTKDAAKQEAIFTKATQIyPNDFRAYNNLgKL 397
Cdd:COG3071  138 LLELLPALRKHKA----------------LSAEEAQAL--ERRAYLGLLRQAARDAEALKALWKAL-PRAERRDPEL-AA 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492406131 398 AY-----QAGDLDKAESYFKKALSIKDAPEANMNLGLIALTKGDR--TAAESYLSKASGSKELNEALGNLYVAQGQYDKA 470
Cdd:COG3071  198 AYaraliALGDHDEAERLLREALKRQWDPRLVRLYGRLQGGDPAKqlKRAEKWLKKHPNDPDLLLALGRLCLRNQLWGKA 277

                        170       180
                 ....*....|....*....|....*.
gi 492406131 471 VSSF------GDTKTNSAALAQILAK 490
Cdd:COG3071  278 REYLeaalalRPSAEAYAELARLLEQ 303
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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