NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|492307043|ref|WP_005804006|]
View 

HAMP domain-containing sensor histidine kinase [Bacteroides fragilis]

Protein Classification

sensor histidine kinase( domain architecture ID 11428264)

sensor histidine kinase is part of a two-component regulatory system and functions as a protein kinase that phosphorylates a target protein in response to a signal

EC:  2.7.13.3
Gene Ontology:  GO:0004673|GO:0007165|GO:0005524|GO:0000160|GO:0016020|GO:0000155
PubMed:  11489844|18076326|10966457|11406410|12372152|8029829

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
199-515 1.36e-32

Signal transduction histidine kinase [Signal transduction mechanisms];


:

Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 126.95  E-value: 1.36e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 199 LIAIGRKSNNASLVARTYENFIVWTDSVKAMTAQDELNVLKRKYDESQQIIQEKEDTLSGKQYMIVGLCTLVVILIAGLI 278
Cdd:COG0642    1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 279 FVAIVLLRFIAGNRKLKKSVQIANEHNELKTQFIQNIS----------------------AQMEPTLDTLASSAAELSDk 336
Cdd:COG0642   81 LLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVShelrtpltairgylellleeldEEQREYLETILRSADRLLR- 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 337 apqqaqqmqgqvaalkkFSNDIQELSTLENSLTEPyEMKEINVNTFCEATMDKVKEFVQP---EVSTVVNAAKLQIKTNP 413
Cdd:COG0642  160 -----------------LINDLLDLSRLEAGKLEL-EPEPVDLAELLEEVVELFRPLAEEkgiELELDLPDDLPTVRGDP 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 414 EQLERILIHLLKNAAEYTESG-KIFLDFKKRGAHTHqFIISDTGTGIPVEKQENLFKPFTEIKD--LTEGDGLGLPICAL 490
Cdd:COG0642  222 DRLRQVLLNLLSNAIKYTPEGgTVTVSVRREGDRVR-ISVEDTGPGIPPEDLERIFEPFFRTDPsrRGGGTGLGLAIVKR 300

                        330       340
                 ....*....|....*....|....*
gi 492307043 491 IATKMNGSLTLDTSYTKGSRFVLEL 515
Cdd:COG0642  301 IVELHGGTIEVESEPGKGTTFTVTL 325
 
Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
199-515 1.36e-32

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 126.95  E-value: 1.36e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 199 LIAIGRKSNNASLVARTYENFIVWTDSVKAMTAQDELNVLKRKYDESQQIIQEKEDTLSGKQYMIVGLCTLVVILIAGLI 278
Cdd:COG0642    1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 279 FVAIVLLRFIAGNRKLKKSVQIANEHNELKTQFIQNIS----------------------AQMEPTLDTLASSAAELSDk 336
Cdd:COG0642   81 LLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVShelrtpltairgylellleeldEEQREYLETILRSADRLLR- 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 337 apqqaqqmqgqvaalkkFSNDIQELSTLENSLTEPyEMKEINVNTFCEATMDKVKEFVQP---EVSTVVNAAKLQIKTNP 413
Cdd:COG0642  160 -----------------LINDLLDLSRLEAGKLEL-EPEPVDLAELLEEVVELFRPLAEEkgiELELDLPDDLPTVRGDP 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 414 EQLERILIHLLKNAAEYTESG-KIFLDFKKRGAHTHqFIISDTGTGIPVEKQENLFKPFTEIKD--LTEGDGLGLPICAL 490
Cdd:COG0642  222 DRLRQVLLNLLSNAIKYTPEGgTVTVSVRREGDRVR-ISVEDTGPGIPPEDLERIFEPFFRTDPsrRGGGTGLGLAIVKR 300

                        330       340
                 ....*....|....*....|....*
gi 492307043 491 IATKMNGSLTLDTSYTKGSRFVLEL 515
Cdd:COG0642  301 IVELHGGTIEVESEPGKGTTFTVTL 325
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 411-516 2.83e-24

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 97.33  E-value: 2.83e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043   411 TNPEQLERILIHLLKNAAEYT-ESGKIFLDFKKRGAHTHqFIISDTGTGIPVEKQENLFKPFTEIKD---LTEGDGLGLP 486
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTpEGGRITVTLERDGDHVE-ITVEDNGPGIPPEDLEKIFEPFFRTDKrsrKIGGTGLGLS 79

                           90       100       110
                   ....*....|....*....|....*....|
gi 492307043   487 ICALIATKMNGSLTLDTSYTKGSRFVLELH 516
Cdd:smart00387  80 IVKKLVELHGGEISVESEPGGGTTFTITLP 109
PRK15347 PRK15347
two component system sensor kinase;
393-515 2.90e-21

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 97.79  E-value: 2.90e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 393 FVQPEVStvvnaakLQIKTNPEQLERILIHLLKNAAEYTESGKIFLDFKKRGAHTHqFIISDTGTGIPVEKQENLFKPFT 472
Cdd:PRK15347 498 FVGAHVP-------LYLHLDSLRLRQILVNLLGNAVKFTETGGIRLRVKRHEQQLC-FTVEDTGCGIDIQQQQQIFTPFY 569

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 492307043 473 EIKDLTEGDGLGLPICALIATKMNGSLTLDTSYTKGSRFVLEL 515
Cdd:PRK15347 570 QADTHSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVL 612
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 411-515 7.12e-21

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 87.81  E-value: 7.12e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043  411 TNPEQLERILIHLLKNAAEYT-ESGKIFLDFKKRGAHThqFIISDTGTGIPVEKQENLFKPFTEIKDL-TEGDGLGLPIC 488
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAaKAGEITVTLSEGGELT--LTVEDNGIGIPPEDLPRIFEPFSTADKRgGGGTGLGLSIV 78

                          90       100
                  ....*....|....*....|....*..
gi 492307043  489 ALIATKMNGSLTLDTSYTKGSRFVLEL 515
Cdd:pfam02518  79 RKLVELLGGTITVESEPGGGTTVTLTL 105
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 416-516 8.35e-21

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 87.55  E-value: 8.35e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 416 LERILIHLLKNAAEYTESGKIFLDFKKRGAHTHQ----FIISDTGTGIPVEKQENLFKPFTEIKDLT----EGDGLGLPI 487
Cdd:cd16922    1 LRQILLNLLGNAIKFTEEGEVTLRVSLEEEEEDGvqlrFSVEDTGIGIPEEQQARLFEPFSQADSSTtrkyGGTGLGLAI 80

                         90       100
                 ....*....|....*....|....*....
gi 492307043 488 CALIATKMNGSLTLDTSYTKGSRFVLELH 516
Cdd:cd16922   81 SKKLVELMGGDISVESEPGQGSTFTFTLP 109
 
Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
199-515 1.36e-32

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 126.95  E-value: 1.36e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 199 LIAIGRKSNNASLVARTYENFIVWTDSVKAMTAQDELNVLKRKYDESQQIIQEKEDTLSGKQYMIVGLCTLVVILIAGLI 278
Cdd:COG0642    1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 279 FVAIVLLRFIAGNRKLKKSVQIANEHNELKTQFIQNIS----------------------AQMEPTLDTLASSAAELSDk 336
Cdd:COG0642   81 LLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVShelrtpltairgylellleeldEEQREYLETILRSADRLLR- 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 337 apqqaqqmqgqvaalkkFSNDIQELSTLENSLTEPyEMKEINVNTFCEATMDKVKEFVQP---EVSTVVNAAKLQIKTNP 413
Cdd:COG0642  160 -----------------LINDLLDLSRLEAGKLEL-EPEPVDLAELLEEVVELFRPLAEEkgiELELDLPDDLPTVRGDP 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 414 EQLERILIHLLKNAAEYTESG-KIFLDFKKRGAHTHqFIISDTGTGIPVEKQENLFKPFTEIKD--LTEGDGLGLPICAL 490
Cdd:COG0642  222 DRLRQVLLNLLSNAIKYTPEGgTVTVSVRREGDRVR-ISVEDTGPGIPPEDLERIFEPFFRTDPsrRGGGTGLGLAIVKR 300

                        330       340
                 ....*....|....*....|....*
gi 492307043 491 IATKMNGSLTLDTSYTKGSRFVLEL 515
Cdd:COG0642  301 IVELHGGTIEVESEPGKGTTFTVTL 325
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
293-515 7.39e-30

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 116.93  E-value: 7.39e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 293 KLKKSVQIANEHNELKTQFIQNIS-------AQMEPTLDTLASSAAELSDKAPQQAQQMQGQVAALKKFSNDIQELSTLE 365
Cdd:COG2205    1 ELEEALEELEELERLKSEFLANVShelrtplTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 366 nSLTEPYEMKEINVNTFCEATMDKVKEFVQP---EVSTVVNAAKLQIKTNPEQLERILIHLLKNAAEYT-ESGKIFLDFK 441
Cdd:COG2205   81 -SGKLSLELEPVDLAELLEEAVEELRPLAEEkgiRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSpPGGTITISAR 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 492307043 442 KRGAHThQFIISDTGTGIPVEKQENLFKPFT--EIKDLTEGDGLGLPICALIATKMNGSLTLDTSYTKGSRFVLEL 515
Cdd:COG2205  160 REGDGV-RISVSDNGPGIPEEELERIFERFYrgDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTL 234
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 411-516 2.83e-24

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 97.33  E-value: 2.83e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043   411 TNPEQLERILIHLLKNAAEYT-ESGKIFLDFKKRGAHTHqFIISDTGTGIPVEKQENLFKPFTEIKD---LTEGDGLGLP 486
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTpEGGRITVTLERDGDHVE-ITVEDNGPGIPPEDLEKIFEPFFRTDKrsrKIGGTGLGLS 79

                           90       100       110
                   ....*....|....*....|....*....|
gi 492307043   487 ICALIATKMNGSLTLDTSYTKGSRFVLELH 516
Cdd:smart00387  80 IVKKLVELHGGEISVESEPGGGTTFTITLP 109
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
305-515 4.25e-24

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 104.25  E-value: 4.25e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 305 NELKTQFIQNIS---------AQMEptLDTLASSAAELSDKAPQQAQQMQGQVAALKKFSNDIQELSTLENSlTEPYEMK 375
Cdd:COG5002  162 EQMRREFVANVShelrtpltsIRGY--LELLLDGAADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESG-ELKLEKE 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 376 EINVNTFCEATMDKVKEFVQP---EVSTVVNAAKLQIKTNPEQLERILIHLLKNAAEYT-ESGKIFLDFKKRGAHTHqFI 451
Cdd:COG5002  239 PVDLAELLEEVVEELRPLAEEkgiELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTpEGGTITVSLREEDDQVR-IS 317

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 492307043 452 ISDTGTGIPVEKQENLFKPF----TEIKDLTEGDGLGLPICALIATKMNGSLTLDTSYTKGSRFVLEL 515
Cdd:COG5002  318 VRDTGIGIPEEDLPRIFERFyrvdKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITL 385
PRK15347 PRK15347
two component system sensor kinase;
393-515 2.90e-21

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 97.79  E-value: 2.90e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 393 FVQPEVStvvnaakLQIKTNPEQLERILIHLLKNAAEYTESGKIFLDFKKRGAHTHqFIISDTGTGIPVEKQENLFKPFT 472
Cdd:PRK15347 498 FVGAHVP-------LYLHLDSLRLRQILVNLLGNAVKFTETGGIRLRVKRHEQQLC-FTVEDTGCGIDIQQQQQIFTPFY 569

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 492307043 473 EIKDLTEGDGLGLPICALIATKMNGSLTLDTSYTKGSRFVLEL 515
Cdd:PRK15347 570 QADTHSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVL 612
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 411-515 7.12e-21

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 87.81  E-value: 7.12e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043  411 TNPEQLERILIHLLKNAAEYT-ESGKIFLDFKKRGAHThqFIISDTGTGIPVEKQENLFKPFTEIKDL-TEGDGLGLPIC 488
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAaKAGEITVTLSEGGELT--LTVEDNGIGIPPEDLPRIFEPFSTADKRgGGGTGLGLSIV 78

                          90       100
                  ....*....|....*....|....*..
gi 492307043  489 ALIATKMNGSLTLDTSYTKGSRFVLEL 515
Cdd:pfam02518  79 RKLVELLGGTITVESEPGGGTTVTLTL 105
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 416-516 8.35e-21

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 87.55  E-value: 8.35e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 416 LERILIHLLKNAAEYTESGKIFLDFKKRGAHTHQ----FIISDTGTGIPVEKQENLFKPFTEIKDLT----EGDGLGLPI 487
Cdd:cd16922    1 LRQILLNLLGNAIKFTEEGEVTLRVSLEEEEEDGvqlrFSVEDTGIGIPEEQQARLFEPFSQADSSTtrkyGGTGLGLAI 80

                         90       100
                 ....*....|....*....|....*....
gi 492307043 488 CALIATKMNGSLTLDTSYTKGSRFVLELH 516
Cdd:cd16922   81 SKKLVELMGGDISVESEPGQGSTFTFTLP 109
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 370-515 2.28e-20

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 92.55  E-value: 2.28e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 370 EPYEMKEINVNTFCEATMdkvkEFVQP-------EVSTVVNAAKLQIKTNPEQLERILIHLLKNAA---EYTESGKIFLD 439
Cdd:COG4191  208 DEEEREPVDLNELIDEAL----ELLRPrlkargiEVELDLPPDLPPVLGDPGQLEQVLLNLLINAIdamEEGEGGRITIS 283

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 492307043 440 FKKRGAHtHQFIISDTGTGIPVEKQENLFKPF--TeiKDLTEGDGLGLPICALIATKMNGSLTLDTSYTKGSRFVLEL 515
Cdd:COG4191  284 TRREGDY-VVISVRDNGPGIPPEVLERIFEPFftT--KPVGKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITL 358
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 356-515 1.21e-17

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 85.61  E-value: 1.21e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 356 NDIQELSTLEnslTEPYEMKEINVNTFCEATMDKVKEfVQPEVSTVVNAAKL-QIKTNPEQLERILIHLLKNAAEYT--- 431
Cdd:COG4251  338 DDLLAYSRVG---RQELEFEPVDLNELLEEVLEDLEP-RIEERGAEIEVGPLpTVRGDPTLLRQVFQNLISNAIKYSrpg 413

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 432 ESGKIFLDFKKRGAHtHQFIISDTGTGIPVEKQENLFKPFT--EIKDLTEGDGLGLPICALIATKMNGSLTLDTSYTKGS 509
Cdd:COG4251  414 EPPRIEIGAEREGGE-WVFSVRDNGIGIDPEYAEKIFEIFQrlHSRDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGA 492


                 ....*.
gi 492307043 510 RFVLEL 515
Cdd:COG4251  493 TFYFTL 498
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
370-515 2.25e-17

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 83.74  E-value: 2.25e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 370 EPYEMKEINVNTFCEatmdKVKEFVQPEVstvvnAAKLQIKT-----------NPEQLERILIHLLKNAAEY-TESGKIF 437
Cdd:COG3852  197 RPPEREPVNLHEVLE----RVLELLRAEA-----PKNIRIVRdydpslpevlgDPDQLIQVLLNLVRNAAEAmPEGGTIT 267

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 438 L------DFKKRGAHTHQFI---ISDTGTGIPVEKQENLFKPF--TeiKDltEGDGLGLPICALIATKMNGSLTLDTSYT 506
Cdd:COG3852  268 IrtrverQVTLGGLRPRLYVrieVIDNGPGIPEEILDRIFEPFftT--KE--KGTGLGLAIVQKIVEQHGGTIEVESEPG 343


                 ....*....
gi 492307043 507 KGSRFVLEL 515
Cdd:COG3852  344 KGTTFRIYL 352
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 351-515 2.29e-17

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 84.24  E-value: 2.29e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 351 LKKFsndIQELSTLeNSLTEPyEMKEINVNTFCEatmdKVKEFVQP-------EVSTVVNAAKLQIKTNPEQLERILIHL 423
Cdd:COG5000  255 LKRI---VDEFLDF-ARLPEP-QLEPVDLNELLR----EVLALYEPalkekdiRLELDLDPDLPEVLADRDQLEQVLINL 325

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 424 LKNAAEYTES-GKIFLDFKkRGAHTHQFIISDTGTGIPVEKQENLFKPF--TeiKdlTEGDGLGLPICALIATKMNGSLT 500
Cdd:COG5000  326 LKNAIEAIEEgGEIEVSTR-REDGRVRIEVSDNGPGIPEEVLERIFEPFftT--K--PKGTGLGLAIVKKIVEEHGGTIE 400

                        170
                 ....*....|....*
gi 492307043 501 LDTSYTKGSRFVLEL 515
Cdd:COG5000  401 LESRPGGGTTFTIRL 415
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 356-515 2.91e-16

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 82.26  E-value: 2.91e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 356 NDIQELSTLENSLT------EPYEMKEInVNTFCEATMDKVKEFVQPEVSTVVNAAKLQIKTNPEQLERILIHLLKNAAE 429
Cdd:PRK11466 497 NDILDYSAIEAGGKnvsvsdEPFEPRPL-LESTLQLMSGRVKGRPIRLATDIADDLPTALMGDPRRIRQVITNLLSNALR 575

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 430 YTESGKIFLdfKKRGAHTHQFI-ISDTGTGIPVEKQENLFKPFTEIKDLTEGDGLGLPICALIATKMNGSLTLDTSYTKG 508
Cdd:PRK11466 576 FTDEGSIVL--RSRTDGEQWLVeVEDSGCGIDPAKLAEIFQPFVQVSGKRGGTGLGLTISSRLAQAMGGELSATSTPEVG 653


                 ....*..
gi 492307043 509 SRFVLEL 515
Cdd:PRK11466 654 SCFCLRL 660
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 360-515 2.31e-15

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 78.48  E-value: 2.31e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 360 ELSTLENSLTE------P--YEMKEINVNTFceatMDKVKEFVQPE-------VSTVVNAAKLQIKTNPEQLERILIHLL 424
Cdd:COG5809  313 ELDRIESIISEflvlakPqaIKYEPKDLNTL----IEEVIPLLQPQallknvqIELELEDDIPDILGDENQLKQVFINLL 388

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 425 KNAAEYTES-GKIFLDFKKRGAHTHQFIISDTGTGIPVEKQENLFKPFTEIKDltEGDGLGLPICALIATKMNGSLTLDT 503
Cdd:COG5809  389 KNAIEAMPEgGNITIETKAEDDDKVVISVTDEGCGIPEERLKKLGEPFYTTKE--KGTGLGLMVSYKIIEEHGGKITVES 466

                        170
                 ....*....|..
gi 492307043 504 SYTKGSRFVLEL 515
Cdd:COG5809  467 EVGKGTTFSITL 478
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 413-515 2.31e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 72.07  E-value: 2.31e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 413 PEQLERILIHLLKNAAEYTES-GKIFLdfkKRGAHTHQFIIS--DTGTGIPVEKQENLFKPFTEIKDLTEGDGLGLPICA 489
Cdd:cd16943    1 PSQLNQVLLNLLVNAAQAMEGrGRITI---RTWAHVDQVLIEveDTGSGIDPEILGRIFDPFFTTKPVGEGTGLGLSLSY 77

                         90       100
                 ....*....|....*....|....*.
gi 492307043 490 LIATKMNGSLTLDTSYTKGSRFVLEL 515
Cdd:cd16943   78 RIIQKHGGTIRVASVPGGGTRFTIIL 103
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 373-515 3.67e-13

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 72.03  E-value: 3.67e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 373 EMKEINVNTFCEATMDKVKEFVQPEVSTVVNAAKLQIKTNPEQLERILIHLLKNAAE-YTESGKIFLDFKKRgAHTHQFI 451
Cdd:COG4192  501 PLQPVDLRQVIEQAWELVESRAKPQQITLHIPDDLMVQGDQVLLEQVLVNLLVNALDaVATQPQISVDLLSN-AENLRVA 579

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 492307043 452 ISDTGTGIPVekQENLFKPFTEIKDLteGDGLGLPICALIATKMNGSLTLDTSYTKGSRFVLEL 515
Cdd:COG4192  580 ISDNGNGWPL--VDKLFTPFTTTKEV--GLGLGLSICRSIMQQFGGDLYLASTLERGAMVILEF 639
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 408-517 7.08e-12

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 68.04  E-value: 7.08e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 408 QIKTNPEQLERILIHLLKNAAEYTESGKIFLDFKKRGAHTHQFIISDTGTGIPVEKQENLFKPFTEIKDLTE-----GDG 482
Cdd:PRK11091 391 KVITDGTRLRQILWNLISNAVKFTQQGGVTVRVRYEEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVKDSHGgkpatGTG 470

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 492307043 483 LGLPICALIATKMNGSLTLDTSYTKGSRFVLELHA 517
Cdd:PRK11091 471 IGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIHA 505
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 403-510 9.40e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 62.04  E-value: 9.40e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 403 NAAKLQIKTNPEQLERILIHLLKNAAEYTESGKIfLDFKKRGAHTHQFIISDTGTGIPVEKQENLFKPFTEI-KDLTEGD 481
Cdd:cd16940    1 SAADIQVQGDALLLFLLLRNLVDNAVRYSPQGSR-VEIKLSADDGAVIRVEDNGPGIDEEELEALFERFYRSdGQNYGGS 79

                         90       100
                 ....*....|....*....|....*....
gi 492307043 482 GLGLPICALIATKMNGSLTLDTSYTKGSR 510
Cdd:cd16940   80 GLGLSIVKRIVELHGGQIFLGNAQGGGLE 108
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 416-515 3.92e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 59.75  E-value: 3.92e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 416 LERILIHLLKNAAEYTESgKIFLDFKKRGAHThQFIISDTGTGIPVEKQENLFKPFTEIKD----LTEGDGLGLPICALI 491
Cdd:cd16939    1 MARALDNLLRNALRYAHR-TVRIALLVSGGRL-TLIVEDDGPGIPAAARERVFEPFVRLDPsrdrATGGFGLGLAIVHRV 78

                         90       100
                 ....*....|....*....|....
gi 492307043 492 ATKMNGSLTLDTSYTKGSRFVLEL 515
Cdd:cd16939   79 ALWHGGHVECDDSELGGACFRLTW 102
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 412-515 5.82e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 59.40  E-value: 5.82e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 412 NPEQLERILIHLLKNAAEYTESGKIFLDFKKRGAHTHQFIISDTGTGIPVEKQENLFKPFTEIKD----LTEGDGLGLPI 487
Cdd:cd16946    1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESsrnrASGGSGLGLAI 80

                         90       100
                 ....*....|....*....|....*...
gi 492307043 488 CALIATKMNGSLTLDTSYTKGSRFVLEL 515
Cdd:cd16946   81 CHNIALAHGGTISAEHSPLGGLRLVLTL 108
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 413-511 1.12e-10

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 64.10  E-value: 1.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 413 PEQLERILIHLLKNAAEYTESGKIFLDFKKRGAHTHQ----FIISDTGTGIPVEKQENLFKPF----TEIKDLTEGDGLG 484
Cdd:PRK11107 406 PLRLQQIITNLVGNAIKFTESGNIDILVELRALSNTKvqleVQIRDTGIGISERQQSQLFQAFrqadASISRRHGGTGLG 485

                         90       100
                 ....*....|....*....|....*..
gi 492307043 485 LPICALIATKMNGSLTLDTSYTKGSRF 511
Cdd:PRK11107 486 LVITQKLVNEMGGDISFHSQPNRGSTF 512
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 412-515 2.69e-10

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 57.50  E-value: 2.69e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 412 NPEQLERILIHLLKNAAEYTESG-KIFLDFKKRGAHTHQFIISDTGTGIPVEKQENLFKPFTEIKDL----TEGDGLGLP 486
Cdd:cd16925    1 DAEKYERVVLNLLSNAFKFTPDGgRIRCILEKFRLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSstraHGGTGLGLS 80

                         90       100
                 ....*....|....*....|....*....
gi 492307043 487 ICALIATKMNGSLTLDTSYTKGSRFVLEL 515
Cdd:cd16925   81 IVKEFVELHGGTVTVSDAPGGGALFQVEL 109
envZ PRK09467
osmolarity sensor protein; Provisional
 397-504 3.02e-10

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 62.24  E-value: 3.02e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 397 EVSTVVNAAKLQIKTNPEQLERILIHLLKNAAEYTESG-KIFLDFKKRGAHthqFIISDTGTGIPVEKQENLFKPFT--E 473
Cdd:PRK09467 313 EIETALQPGPIEVPMNPIAIKRALANLVVNAARYGNGWiKVSSGTEGKRAW---FQVEDDGPGIPPEQLKHLFQPFTrgD 389

                         90       100       110
                 ....*....|....*....|....*....|.
gi 492307043 474 IKDLTEGDGLGLPICALIATKMNGSLTLDTS 504
Cdd:PRK09467 390 SARGSSGTGLGLAIVKRIVDQHNGKVELGNS 420
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 416-515 3.33e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 57.08  E-value: 3.33e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 416 LERILIHLLKNAA---EYTESGKIFLDFKKRGAHThQFIISDTGTGIPVEKQENLFKPFTEIKDLTEGDGLGLPICALIA 492
Cdd:cd16976    1 IQQVLMNLLQNALdamGKVENPRIRIAARRLGGRL-VLVVRDNGPGIAEEHLSRVFDPFFTTKPVGKGTGLGLSISYGIV 79

                         90       100
                 ....*....|....*....|...
gi 492307043 493 TKMNGSLTLDTSYTKGSRFVLEL 515
Cdd:cd16976   80 EEHGGRLSVANEEGAGARFTFDL 102
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
393-515 3.68e-10

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 62.68  E-value: 3.68e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 393 FVQPEVSTVVNAaklqiktNPEQLERILIHLLKNAAEYTESGKIFLDFKKRGAHThQFIISDTGTGIPVEKQENLFKPFT 472
Cdd:PRK10841 547 FIEPDVPVALNG-------DPMRLQQVISNLLSNAIKFTDTGCIVLHVRVDGDYL-SFRVRDTGVGIPAKEVVRLFDPFF 618

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 492307043 473 EIKDLTE----GDGLGLPICALIATKMNGSLTLDTSYTKGSRFVLEL 515
Cdd:PRK10841 619 QVGTGVQrnfqGTGLGLAICEKLINMMDGDISVDSEPGMGSQFTIRI 665
PRK09303 PRK09303
histidine kinase;
413-511 4.22e-10

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 61.51  E-value: 4.22e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 413 PEQLERILIHLLKNAAEYT-ESGKIFLDFKKRGAHTHQFIISDTGTGIPVEKQENLFKPFTEIK--DLTEGDGLGLPICA 489
Cdd:PRK09303 270 QERIRQVLLNLLDNAIKYTpEGGTITLSMLHRTTQKVQVSICDTGPGIPEEEQERIFEDRVRLPrdEGTEGYGIGLSVCR 349

                         90       100
                 ....*....|....*....|..
gi 492307043 490 LIATKMNGSLTLDTSYTKGSRF 511
Cdd:PRK09303 350 RIVRVHYGQIWVDSEPGQGSCF 371
PRK10604 PRK10604
sensor protein RstB; Provisional
 416-513 1.14e-09

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 60.39  E-value: 1.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 416 LERILIHLLKNAAEYTESG-KIFLDFKKRGAhthQFIISDTGTGIPVEKQENLFKPFTEI---KD-LTEGDGLGLPICAL 490
Cdd:PRK10604 320 MERVLDNLLNNALRYAHSRvRVSLLLDGNQA---CLIVEDDGPGIPPEERERVFEPFVRLdpsRDrATGGCGLGLAIVHS 396

                         90       100
                 ....*....|....*....|...
gi 492307043 491 IATKMNGSLTLDTSYTKGSRFVL 513
Cdd:PRK10604 397 IALAMGGSVNCDESELGGARFSF 419
PRK10618 PRK10618
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
 291-516 2.98e-09

phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional


Pssm-ID: 236726 [Multi-domain]  Cd Length: 894  Bit Score: 59.56  E-value: 2.98e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 291 NRKLKKSVQIANEHNELKTQFIQNISAQMEPTLDTLASSAAELSDKAPQQAQQMQGQVAALK-----KFSNDIQELSTLE 365
Cdd:PRK10618 433 NKKLQQAQREYEKNQQARKAFLQNIGDELKQPLQSLAQLAAQLRQTSDEEQQQPELDQLAEQsdvlvRLVDNIQLLNMLE 512

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 366 NSLTEPyEMKEINVNTFCEAtmdkvkefVQPEVSTVVNAAKLQI----KTNPEQ--------LERILIHLLKNAAEYTES 433
Cdd:PRK10618 513 TQDWKP-EQELFSLQDLIDE--------VLPEVLPAIKRKGLQLlihnHLKAEQlrigdrdaLRKILLLLLNYAITTTAY 583

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 434 GKIFL--DFKKRGAHTHQFIISDTGTGIPVEKQENLFKPFteikdLTE--------GDGLGLPICALIATKMNGSLTLDT 503
Cdd:PRK10618 584 GKITLevDQDESSPDRLTIRILDTGAGVSIKELDNLHFPF-----LNQtqgdrygkASGLTFFLCNQLCRKLGGHLTIKS 658

                        250
                 ....*....|...
gi 492307043 504 SYTKGSRFVLELH 516
Cdd:PRK10618 659 REGLGTRYSIHLK 671
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 416-515 4.24e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 53.94  E-value: 4.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 416 LERILIHLLKNAAE-----YTESGKIFLDFKKRGAHTHQFIISDTGTGIPVEKQENLFKPFTEIKdlTEGDGLGLPICAL 490
Cdd:cd16920    1 IQQVLINLVRNGIEamsegGCERRELTIRTSPADDRAVTISVKDTGPGIAEEVAGQLFDPFYTTK--SEGLGMGLSICRS 78

                         90       100
                 ....*....|....*....|....*
gi 492307043 491 IATKMNGSLTLDTSYTKGSRFVLEL 515
Cdd:cd16920   79 IIEAHGGRLSVESPAGGGATFQFTL 103
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
413-515 6.12e-09

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 58.44  E-value: 6.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 413 PEQLERILIHLLKNAAE-YTESGKIFLDFKKRGAHTHQFIISDTGTGIPVEKQENLFKPFTEIKDltEGDGLGLPICALI 491
Cdd:PRK11360 498 PELLKQVLLNILINAVQaISARGKIRIRTWQYSDGQVAVSIEDNGCGIDPELLKKIFDPFFTTKA--KGTGLGLALSQRI 575

                         90       100
                 ....*....|....*....|....
gi 492307043 492 ATKMNGSLTLDTSYTKGSRFVLEL 515
Cdd:PRK11360 576 INAHGGDIEVESEPGVGTTFTLYL 599
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 412-515 6.13e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 54.06  E-value: 6.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 412 NPEQLERILIHLLKNAAEYTESGKiFLDFKKRGAHTHQFI-ISDTGTGIPVEKQENLFKPFTEIKD----LTEGDGLGLP 486
Cdd:cd16947   17 NTEALQRILKNLISNAIKYGSDGK-FLGMTLREDEKHVYIdIWDKGKGISETEKDHVFERLYTLEDsrnsAKQGNGLGLT 95

                         90       100
                 ....*....|....*....|....*....
gi 492307043 487 ICALIATKMNGSLTLDTSYTKGSRFVLEL 515
Cdd:cd16947   96 ITKRLAESMGGSIYVNSKPYEKTVFTVTL 124
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 384-515 8.69e-09

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 57.82  E-value: 8.69e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 384 EATMDKVkefvqpEVSTVVNAAKLQIKTNPEQLERILIHLLKNAAEYTES-GKIFLdfkkRGAHTHQFI---ISDTGTGI 459
Cdd:COG5805  370 EAILHNI------QIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNgGTITI----HTEEEDNSViirVIDEGIGI 439

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 492307043 460 PVEKQENLFKPFTEIKDltEGDGLGLPICALIATKMNGSLTLDTSYTKGSRFVLEL 515
Cdd:COG5805  440 PEERLKKLGEPFFTTKE--KGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITL 493
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 416-515 1.10e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 52.71  E-value: 1.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 416 LERILIHLLKNAAEYTESgKIFLDFKKRGAHTHqFIISDTGTGIPVEKQENLFKPFTEIKDL----TEGDGLGLPICALI 491
Cdd:cd16949    1 LARALENVLRNALRYSPS-KILLDISQDGDQWT-ITITDDGPGVPEDQLEQIFLPFYRVDSArdreSGGTGLGLAIAERA 78

                         90       100
                 ....*....|....*....|....
gi 492307043 492 ATKMNGSLTLDTSYTKGSRFVLEL 515
Cdd:cd16949   79 IEQHGGKIKASNRKPGGLRVRIWL 102
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 412-515 1.45e-08

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 56.78  E-value: 1.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 412 NPEQLERILIHLLKNAAEYTES-----GKIFLDFKKRGAHTHqFIISDTGTGIPVEKQENLFKPFTEIKDlTEGDGLGLP 486
Cdd:COG3290  278 SDTDLVTILGNLLDNAIEAVEKlpeeeRRVELSIRDDGDELV-IEVEDSGPGIPEELLEKIFERGFSTKL-GEGRGLGLA 355

                         90       100
                 ....*....|....*....|....*....
gi 492307043 487 ICALIATKMNGSLTLDTSYTKGSRFVLEL 515
Cdd:COG3290  356 LVKQIVEKYGGTIEVESEEGEGTVFTVRL 384
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 415-515 1.74e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 52.54  E-value: 1.74e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 415 QLERILIHLLKNAAEYTES-----GKIFLDFKKRGAHTHQFIISDTGTGIPVEKQENLFKPFteIKDLTEGDGLGLPICA 489
Cdd:cd16944    4 QISQVLTNILKNAAEAIEGrpsdvGEVRIRVEADQDGRIVLIVCDNGKGFPREMRHRATEPY--VTTRPKGTGLGLAIVK 81

                         90       100
                 ....*....|....*....|....*.
gi 492307043 490 LIATKMNGSLTLDTSYTKGSRFVLEL 515
Cdd:cd16944   82 KIMEEHGGRISLSNREAGGACIRIIL 107
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 416-515 1.95e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 52.33  E-value: 1.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 416 LERILIHLLKNAAEYT--------ESGKIfldfkkRGAHTHQFIISDTGTGIPVEKQENLFKPFTEI--KDLTEGDGLGL 485
Cdd:cd16921    1 LGQVLTNLLGNAIKFRrprrppriEVGAE------DVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLhsREEYEGTGVGL 74

                         90       100       110
                 ....*....|....*....|....*....|
gi 492307043 486 PICALIATKMNGSLTLDTSYTKGSRFVLEL 515
Cdd:cd16921   75 AIVRKIIERHGGRIWLESEPGEGTTFYFTL 104
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 416-504 3.30e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 51.30  E-value: 3.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 416 LERILIHLLKNAAEYTE-SGKIFLDFKKRGAhthQFIISDTGTGIPVEKQENLFKPFT--EIKDLTEGDGLGLPICALIA 492
Cdd:cd16950    1 LKRVLSNLVDNALRYGGgWVEVSSDGEGNRT---RIQVLDNGPGIAPEEVDELFQPFYrgDNARGTSGTGLGLAIVQRIS 77

                         90
                 ....*....|..
gi 492307043 493 TKMNGSLTLDTS 504
Cdd:cd16950   78 DAHGGSLTLANR 89
KinB COG5806
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ...
 407-515 8.69e-08

Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444508 [Multi-domain]  Cd Length: 412  Bit Score: 54.49  E-value: 8.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 407 LQIKTNPEQLERILIHLLKNAAEYTES-GKIFLDFKKRGAHTHqFIISDTGTGIPVEKQENLFKPFTEIKdlTEGDGLGL 485
Cdd:COG5806  303 LYIEGDRQKLQQCLINIIKNGIEAMPNgGTLTIDVSIDKNKVI-ISIKDTGVGMTKEQLERLGEPYFSTK--EKGTGLGT 379

                         90       100       110
                 ....*....|....*....|....*....|
gi 492307043 486 PICALIATKMNGSLTLDTSYTKGSRFVLEL 515
Cdd:COG5806  380 MVSYRIIEAMNGTIRVESEVGKGTTFTITL 409
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
409-515 2.39e-07

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 53.58  E-value: 2.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043  409 IKTNPEQLERILIHLLKNAAEYTESGKIfldfKKRGAHTH--------QFIISDTGTGIPVEKQENLFKPFTEIKDLTE- 479
Cdd:PRK09959  822 VKIDPQAFKQVLSNLLSNALKFTTEGAV----KITTSLGHiddnhaviKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQq 897

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 492307043  480 -GDGLGLPICALIATKMNGSLTLDTSYTKGSRFVLEL 515
Cdd:PRK09959  898 tGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITI 934
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 450-515 1.89e-06

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 46.60  E-value: 1.89e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 492307043 450 FIISDTGTGIPVEKQENLFKPFTEIKDLTEGDGLGLPICALIATKMNGSLTLDTSYTKGSRFVLEL 515
Cdd:cd16919   50 LEVSDTGSGMPAEVLRRAFEPFFTTKEVGKGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYL 115
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
404-515 2.40e-06

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 50.45  E-value: 2.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 404 AAKLQIKTNPEQLERILIHLLKNAAE-YTESG--KIFLD---FKKRGAHTHQFI---------ISDTGTGIPVEKQENLF 468
Cdd:PRK13837 549 QEPAVVEGNPAELQQVLMNLCSNAAQaMDGAGrvDISLSrakLRAPKVLSHGVLppgryvllrVSDTGAGIDEAVLPHIF 628

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 492307043 469 KPFTEIKdlTEGDGLGLPICALIATKMNGSLTLDTSYTKGSRFVLEL 515
Cdd:PRK13837 629 EPFFTTR--AGGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYL 673
PRK10490 PRK10490
sensor protein KdpD; Provisional
 416-515 2.44e-06

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 50.42  E-value: 2.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 416 LERILIHLLKNAAEYT-ESGKIFLDFKKRGAHTHqFIISDTGTGIPVEKQENLFKPFT--EIKDLTEGDGLGLPICALIA 492
Cdd:PRK10490 779 FERVLINLLENAVKYAgAQAEIGIDAHVEGERLQ-LDVWDNGPGIPPGQEQLIFDKFArgNKESAIPGVGLGLAICRAIV 857

                         90       100
                 ....*....|....*....|...
gi 492307043 493 TKMNGSLTLDTSYTKGSRFVLEL 515
Cdd:PRK10490 858 EVHGGTIWAENRPEGGACFRVTL 880
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
368-515 3.09e-06

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 49.78  E-value: 3.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 368 LTEPYEM--KEINVNTFCEATMDKVKEFVQP---EVSTVVNAAKLQIKTNPEQLERILIHLLKNAAEYT-ESGKIFLDFK 441
Cdd:PRK10364 296 LVKPTHLalQAVDLNDLINHSLQLVSQDANSreiQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIgQHGVISVTAS 375

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 492307043 442 KRGAHThQFIISDTGTGIPVEKQENLFKPFTEIKdlTEGDGLGLPICALIATKMNGSLTLDTSYTKGSRFVLEL 515
Cdd:PRK10364 376 ESGAGV-KISVTDSGKGIAADQLEAIFTPYFTTK--AEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWL 446
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 351-515 3.61e-06

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 49.52  E-value: 3.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 351 LKKFSNDIQELSTLENSLTEPYEMKEINVNTFCEATMDKVKE-FVQPEVSTVVNAAKLQIktNPEQLERI--LIH-LLKN 426
Cdd:COG3920  333 LEESQNRIQALALVHELLYQSEDWEGVDLRDYLRELLEPLRDsYGGRGIRIELDGPDVEL--PADAAVPLglILNeLVTN 410

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 427 AAEY----TESGKIFLDFKKRGAHTHqFIISDTGTGIPvekqenlfkpftEIKDLTEGDGLGLPICALIATKMNGSLTLD 502
Cdd:COG3920  411 ALKHaflsGEGGRIRVSWRREDGRLR-LTVSDNGVGLP------------EDVDPPARKGLGLRLIRALVRQLGGTLELD 477

                        170
                 ....*....|...
gi 492307043 503 TSytKGSRFVLEL 515
Cdd:COG3920  478 RP--EGTRVRITF 488
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 412-515 5.32e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 46.09  E-value: 5.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 412 NPEQLERILIHLLKNAAEYTeSGKIFLDFKKRGAHTHqFIISDTGTGIPVEKQENLFKPFTEIKDLTEGDGLGLPICALI 491
Cdd:cd16954   34 ERNDLMELLGNLLDNACKWC-LEFVEVTARQTDGGLH-LIVDDDGPGVPESQRSKIFQRGQRLDEQRPGQGLGLAIAKEI 111

                         90       100
                 ....*....|....*....|....
gi 492307043 492 ATKMNGSLTLDTSYTKGSRFVLEL 515
Cdd:cd16954  112 VEQYGGELSLSDSPLGGARFEVVF 135
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 416-504 6.67e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 45.08  E-value: 6.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 416 LERILIHLLKNAAEYTES--GKIFLdfkkRGAHTHQFIIS-------------DTGTGIPVEKQENLFKPFTEIKDltEG 480
Cdd:cd16918    1 LIQVFLNLVRNAAQALAGsgGEIIL----RTRTQRQVTLGhprhrlalrvsviDNGPGIPPDLQDTIFYPMVSGRE--NG 74

                         90       100
                 ....*....|....*....|....
gi 492307043 481 DGLGLPICALIATKMNGSLTLDTS 504
Cdd:cd16918   75 TGLGLAIAQNIVSQHGGVIECDSQ 98
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 360-517 6.95e-06

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 48.69  E-value: 6.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 360 ELSTLENsLTEPYEMKEINVNTFCEATMDKVK-EFVQPEVSTVVNAAKLQIKTNPEQLERILIHLLKNAAEYT-ESGKIF 437
Cdd:PRK11100 313 ELARLEQ-RQELEVLEPVALAALLEELVEAREaQAAAKGITLRLRPDDARVLGDPFLLRQALGNLLDNAIDFSpEGGTIT 391

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 438 LDFKKRGaHTHQFIISDTGTGIPVEKQENLFKPF-------TEIKdlteGDGLGLPICALIATKMNGSLTLDTSYTKGSR 510
Cdd:PRK11100 392 LSAEVDG-EQVALSVEDQGPGIPDYALPRIFERFyslprpaNGRK----STGLGLAFVREVARLHGGEVTLRNRPEGGVL 466


                 ....*..
gi 492307043 511 FVLELHA 517
Cdd:PRK11100 467 ATLTLPR 473
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 412-501 6.11e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 42.06  E-value: 6.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 412 NPEQLERILIHLLKNAAEYT-ESGKIFLDFKKRGAHThQFIISDTGTGIPVEKQENLFKPFTEIKDLTEGD---GLGLPI 487
Cdd:cd16945    1 DPFLLRQAINNLLDNAIDFSpEGGLIALQLEADTEGI-ELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQkstGLGLAF 79

                         90
                 ....*....|....
gi 492307043 488 CALIATKMNGSLTL 501
Cdd:cd16945   80 VQEVAQLHGGRITL 93
glnL PRK11073
nitrogen regulation protein NR(II);
413-487 9.25e-05

nitrogen regulation protein NR(II);


Pssm-ID: 182947 [Multi-domain]  Cd Length: 348  Bit Score: 44.69  E-value: 9.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 413 PEQLERILIHLLKNAAEY--TESGKIFLdfKKRGAHT-------HQFI----ISDTGTGIPVEKQENLFKPFTEIKDltE 479
Cdd:PRK11073 235 PDQIEQVLLNIVRNALQAlgPEGGTITL--RTRTAFQltlhgerYRLAaridIEDNGPGIPPHLQDTLFYPMVSGRE--G 310


                 ....*...
gi 492307043 480 GDGLGLPI 487
Cdd:PRK11073 311 GTGLGLSI 318
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
320-515 9.53e-05

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 45.01  E-value: 9.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 320 EPTLDTLASSAAELSdkapqqaqqmqgqvaALKKFSNDIQELS-TLENSLTepYEMKEINVNTFCEATMDKVKEFVQPEV 398
Cdd:PRK10549 271 KFTPESVASLQAEVG---------------TLTKLVDDLHQLSlSDEGALA--YRKTPVDLVPLLEVAGGAFRERFASRG 333

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 399 STVVNAAKLQIKT--NPEQLERILIHLLKNAAEYTESGKIFLDFKKRGAHTHQFIISDTGTGIPVEKQENLFKPFTEikd 476
Cdd:PRK10549 334 LTLQLSLPDSATVfgDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYR--- 410

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 492307043 477 lTE--------GDGLGLPICALIATKMNGSLTLDTSYTKGSRFVLEL 515
Cdd:PRK10549 411 -TEgsrnrasgGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVEL 456
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 412-514 1.00e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 41.68  E-value: 1.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 412 NPEQLERILIHLLKNAAEYTESGKIFLDFKKRGAHTHQFIISDTGTGIPVEKQENLFKPF-TEIKDLTEGD--GLGLPIC 488
Cdd:cd16975    1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFyRDDTSRRSGGhyGMGLYIA 80

                         90       100
                 ....*....|....*....|....*.
gi 492307043 489 ALIATKMNGSLTLDTSYTKGSRFVLE 514
Cdd:cd16975   81 KNLVEKHGGSLIIENSQKGGAEVTVK 106
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
412-515 1.46e-04

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 44.15  E-value: 1.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 412 NPEQLERILIHLLKNAAEYTESgKIFLDFKkrgAHTHQFIIS--DTGTGIPVEKQENLFKPF---TEIKDL-TEGDGLGL 485
Cdd:PRK09470 350 NPNALASALENIVRNALRYSHT-KIEVAFS---VDKDGLTITvdDDGPGVPEEEREQIFRPFyrvDEARDReSGGTGLGL 425

                         90       100       110
                 ....*....|....*....|....*....|
gi 492307043 486 PICALIATKMNGSLTLDTSYTKGSRFVLEL 515
Cdd:PRK09470 426 AIVENAIQQHRGWVKAEDSPLGGLRLTIWL 455
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 416-515 2.28e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 40.63  E-value: 2.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 416 LERILIHLLKNAAEYT--ESGKIFLDfKKRGAHTHQFIISDTGTGIPVEKQENLFKPFTEIKDLTEG----DGLGLPICA 489
Cdd:cd16953    1 LGQVLRNLIGNAISFSppDTGRITVS-AMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAfgqhSGLGLSISR 79

                         90       100       110
                 ....*....|....*....|....*....|
gi 492307043 490 LIATKMNGSLTL----DTSYTKGSRFVLEL 515
Cdd:cd16953   80 QIIEAHGGISVAenhnQPGQVIGARFTVQL 109
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 419-515 2.70e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 40.35  E-value: 2.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 419 ILIHLLKNA-----AEYTESGKIFLDFKKRGAHTHqFIISDTGTGIPVEKQENLFKPFTEIKDLTEgDGLGLPICALIAT 493
Cdd:cd16915    4 IVGNLIDNAldalaATGAPNKQVEVFLRDEGDDLV-IEVRDTGPGIAPELRDKVFERGVSTKGQGE-RGIGLALVRQSVE 81

                         90       100
                 ....*....|....*....|..
gi 492307043 494 KMNGSLTLDTSYTKGSRFVLEL 515
Cdd:cd16915   82 RLGGSITVESEPGGGTTFSIRI 103
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
405-515 2.99e-04

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 43.08  E-value: 2.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 405 AKLQIKTNPEQLERILIHLLKNAAEYTESG-KIFLDFKkRGAHTHQFIISDTGTGIPVEKQENLFKPFTEIKDL----TE 479
Cdd:PRK11006 307 NSLKVFGNEDQLRSAISNLVYNAVNHTPEGtHITVRWQ-RVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKArsrqTG 385

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 492307043 480 GDGLGLPICALIATKMNGSLTLDTSYTKGSRFVLEL 515
Cdd:PRK11006 386 GSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVL 421
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 422-511 1.00e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 38.72  E-value: 1.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 422 HLLKNAAEYT-ESGKIFLDFKK--RGAHthqFIISDTGTGIPVEKQENLFKPFTEIKDL----TEGDGLGLPICALIATK 494
Cdd:cd16952    7 NLVSNAVKYTpPSDTITVRWSQeeSGAR---LSVEDTGPGIPPEHIPRLTERFYRVDIErcrnTGGTGLGLAIVKHVMSR 83

                         90
                 ....*....|....*..
gi 492307043 495 MNGSLTLDTSYTKGSRF 511
Cdd:cd16952   84 HDARLLIASELGKGSRF 100
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
423-510 1.65e-03

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 41.16  E-value: 1.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 423 LLKNAAEYTesgkifLDFKKRGA-HTHQ---FIISDTGTGIPVEKQENLFKPFTEIKDLTEGDGLGLPICALIATKMNGS 498
Cdd:PRK10815 386 VLDNACKYC------LEFVEISArQTDEhlhIVVEDDGPGIPESKRELIFDRGQRADTLRPGQGLGLSVAREITEQYEGK 459

                         90
                 ....*....|..
gi 492307043 499 LTLDTSYTKGSR 510
Cdd:PRK10815 460 ISAGDSPLGGAR 471
HATPase_CheA-like cd16916
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ...
 414-515 3.86e-03

Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.


Pssm-ID: 340393 [Multi-domain]  Cd Length: 178  Bit Score: 38.33  E-value: 3.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 414 EQLERILIHLLKNAAEY-------------TESGKIFLDFKKRGAHTHqFIISDTGTGIPVEK-----QEN--------- 466
Cdd:cd16916   37 EKLADPLTHLLRNAVDHgieapeerlaagkPPEGTITLRAEHQGNQVV-IEVSDDGRGIDREKirekaIERglitadeaa 115

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 492307043 467 ----------LFKP-FTEIKDLTE--GDGLGLPICALIATKMNGSLTLDTSYTKGSRFVLEL 515
Cdd:cd16916  116 tlsddevlnlIFAPgFSTAEQVTDvsGRGVGMDVVKRSIESLGGTIEVESEPGQGTTFTIRL 177
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 413-515 5.10e-03

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 38.09  E-value: 5.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 413 PEQLERILIHLLKNAAEYT-ESGKIFLDFKK------RGAHTHQFI-ISDTGTGIPVEKQENLFK------------PFT 472
Cdd:cd16929   41 PSHLYYILFELLKNAMRATvESHGDDSDDLPpikvtvAKGDEDLTIkISDRGGGIPREDLARLFSymystapqpsldDFS 120

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 492307043 473 EIKDLTE-----GDGLGLPICALIATKMNGSLTLDTSYTKGSRFVLEL 515
Cdd:cd16929  121 DLISGTQpsplaGFGYGLPMSRLYAEYFGGDLDLQSMEGYGTDVYIYL 168
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
404-501 6.48e-03

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 38.80  E-value: 6.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 404 AAKLQIKTNPEQLERILIHLLKNAAEYTESG---KIFLDFKKRGAHthqFIISDTGTGIPVEKQENLFKPFTEIKDLTEG 480
Cdd:PRK10755 236 AADITVQGDATLLRLLLRNLVENAHRYSPEGstiTIKLSQEDGGAV---LAVEDEGPGIDESKCGELSKAFVRMDSRYGG 312

                         90       100
                 ....*....|....*....|.
gi 492307043 481 DGLGLPICALIATKMNGSLTL 501
Cdd:PRK10755 313 IGLGLSIVSRITQLHHGQFFL 333
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 419-513 6.96e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 36.49  E-value: 6.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492307043 419 ILIHLLKNAAEYT-ESGKIFLDFKKRGAHThQFIISDTGTGIPVEKQENLFKP-FTEIKD--LTEGDGLGLPICALIATK 494
Cdd:cd16948    9 IIGQIVSNALKYSkQGGKIEIYSETNEQGV-VLSIKDFGIGIPEEDLPRVFDKgFTGENGrnFQESTGMGLYLVKKLCDK 87

                         90
                 ....*....|....*....
gi 492307043 495 MNGSLTLDTSYTKGSRFVL 513
Cdd:cd16948   88 LGHKIDVESEVGEGTTFTI 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH