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Conserved domains on  [gi|492255741|ref|WP_005791935|]
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6-bladed beta-propeller [Bacteroides fragilis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF5128 super family cl44435
6-bladed beta-propeller; This family is a 6-bladed beta-propeller structure of unknown ...
 58-160 8.26e-13

6-bladed beta-propeller; This family is a 6-bladed beta-propeller structure of unknown function. There is a highly conserved FDxxG motif which might be important.


The actual alignment was detected with superfamily member pfam17170:

Pssm-ID: 407298 [Multi-domain]  Cd Length: 321  Bit Score: 68.51  E-value: 8.26e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255741   58 VNFPLSQLTEELQIVKLDNRDEALIGGWIRTTVGEKYILVSNNKQTPYKLFDRTGKFITNIGSYGQGPNEYLNTYAEQLD 137
Cdd:pfam17170  19 KDVKLSSLFDSVEFIPLETTDSCLIGDISRIKFVDDRIFVFDSNTNNLFVFDKKGKFVRQIGAQGNGPGEYLQINDFIID 98

                          90       100
                  ....*....|....*....|...
gi 492255741  138 EANNRIYILPWQSSKILVFDLKG 160
Cdd:pfam17170  99 KSNNSIYILDFMQNKILTYDLDG 121
NHL super family cl18310
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 88-237 8.72e-06

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


The actual alignment was detected with superfamily member cd14963:

Pssm-ID: 302697 [Multi-domain]  Cd Length: 268  Bit Score: 46.90  E-value: 8.72e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255741  88 TTVGEKYILV--SNNKQTpyKLFDRTGKFITNIGSYGQGPNEYLNTYAEQLDEaNNRIYILPWQSSKILVFDLKGNALD- 164
Cdd:cd14963   15 VAVSDGRIYVadTNNHRV--QVFDYEGKFKKSFGGPGTGPGEFKYPYGIAVDS-DGNIYVADLYNGRIQVFDPDGKFLKy 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255741 165 ----------PIPLCLRVPKGKFRV-NTAKSEVTVtvlpFpkwpavvwtqDLKGKR-KNFVAPGSLAMPQDFSNEVSMGN 232
Cdd:cd14963   92 fpekkdrvklISPAGLAIDDGKLYVsDVKKHKVIV----F----------DLEGKLlLEFGKPGSEPGELSYPNGIAVDE 157


                 ....*
gi 492255741 233 NTAAY 237
Cdd:cd14963  158 DGNIY 162
 
Name Accession Description Interval E-value
DUF5128 pfam17170
6-bladed beta-propeller; This family is a 6-bladed beta-propeller structure of unknown ...
 58-160 8.26e-13

6-bladed beta-propeller; This family is a 6-bladed beta-propeller structure of unknown function. There is a highly conserved FDxxG motif which might be important.


Pssm-ID: 407298 [Multi-domain]  Cd Length: 321  Bit Score: 68.51  E-value: 8.26e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255741   58 VNFPLSQLTEELQIVKLDNRDEALIGGWIRTTVGEKYILVSNNKQTPYKLFDRTGKFITNIGSYGQGPNEYLNTYAEQLD 137
Cdd:pfam17170  19 KDVKLSSLFDSVEFIPLETTDSCLIGDISRIKFVDDRIFVFDSNTNNLFVFDKKGKFVRQIGAQGNGPGEYLQINDFIID 98

                          90       100
                  ....*....|....*....|...
gi 492255741  138 EANNRIYILPWQSSKILVFDLKG 160
Cdd:pfam17170  99 KSNNSIYILDFMQNKILTYDLDG 121
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 95-166 4.79e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 47.67  E-value: 4.79e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 492255741  95 ILVSNNKQTPYKLFDRTGKFITNIGSYGQGPNEYLNTYAEQLDEaNNRIYILPWQSSKILVFDLKGNALDPI 166
Cdd:cd14963  114 LYVSDVKKHKVIVFDLEGKLLLEFGKPGSEPGELSYPNGIAVDE-DGNIYVADSGNGRIQVFDKNGKFIKEL 184
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 88-237 8.72e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 46.90  E-value: 8.72e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255741  88 TTVGEKYILV--SNNKQTpyKLFDRTGKFITNIGSYGQGPNEYLNTYAEQLDEaNNRIYILPWQSSKILVFDLKGNALD- 164
Cdd:cd14963   15 VAVSDGRIYVadTNNHRV--QVFDYEGKFKKSFGGPGTGPGEFKYPYGIAVDS-DGNIYVADLYNGRIQVFDPDGKFLKy 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255741 165 ----------PIPLCLRVPKGKFRV-NTAKSEVTVtvlpFpkwpavvwtqDLKGKR-KNFVAPGSLAMPQDFSNEVSMGN 232
Cdd:cd14963   92 fpekkdrvklISPAGLAIDDGKLYVsDVKKHKVIV----F----------DLEGKLlLEFGKPGSEPGELSYPNGIAVDE 157


                 ....*
gi 492255741 233 NTAAY 237
Cdd:cd14963  158 DGNIY 162
 
Name Accession Description Interval E-value
DUF5128 pfam17170
6-bladed beta-propeller; This family is a 6-bladed beta-propeller structure of unknown ...
 58-160 8.26e-13

6-bladed beta-propeller; This family is a 6-bladed beta-propeller structure of unknown function. There is a highly conserved FDxxG motif which might be important.


Pssm-ID: 407298 [Multi-domain]  Cd Length: 321  Bit Score: 68.51  E-value: 8.26e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255741   58 VNFPLSQLTEELQIVKLDNRDEALIGGWIRTTVGEKYILVSNNKQTPYKLFDRTGKFITNIGSYGQGPNEYLNTYAEQLD 137
Cdd:pfam17170  19 KDVKLSSLFDSVEFIPLETTDSCLIGDISRIKFVDDRIFVFDSNTNNLFVFDKKGKFVRQIGAQGNGPGEYLQINDFIID 98

                          90       100
                  ....*....|....*....|...
gi 492255741  138 EANNRIYILPWQSSKILVFDLKG 160
Cdd:pfam17170  99 KSNNSIYILDFMQNKILTYDLDG 121
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 95-166 4.79e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 47.67  E-value: 4.79e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 492255741  95 ILVSNNKQTPYKLFDRTGKFITNIGSYGQGPNEYLNTYAEQLDEaNNRIYILPWQSSKILVFDLKGNALDPI 166
Cdd:cd14963  114 LYVSDVKKHKVIVFDLEGKLLLEFGKPGSEPGELSYPNGIAVDE-DGNIYVADSGNGRIQVFDKNGKFIKEL 184
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 88-237 8.72e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 46.90  E-value: 8.72e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255741  88 TTVGEKYILV--SNNKQTpyKLFDRTGKFITNIGSYGQGPNEYLNTYAEQLDEaNNRIYILPWQSSKILVFDLKGNALD- 164
Cdd:cd14963   15 VAVSDGRIYVadTNNHRV--QVFDYEGKFKKSFGGPGTGPGEFKYPYGIAVDS-DGNIYVADLYNGRIQVFDPDGKFLKy 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255741 165 ----------PIPLCLRVPKGKFRV-NTAKSEVTVtvlpFpkwpavvwtqDLKGKR-KNFVAPGSLAMPQDFSNEVSMGN 232
Cdd:cd14963   92 fpekkdrvklISPAGLAIDDGKLYVsDVKKHKVIV----F----------DLEGKLlLEFGKPGSEPGELSYPNGIAVDE 157


                 ....*
gi 492255741 233 NTAAY 237
Cdd:cd14963  158 DGNIY 162
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 108-161 1.52e-03

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 39.87  E-value: 1.52e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 492255741 108 FDRTGKFITNIGSYGQGPNEYLNTYAEQLDEANNrIYILPWQSSKILVFDLKGN 161
Cdd:cd14955  136 FDSSGTFITKWGSFGSGDGQFNSPTGIAVDSAGN-VYVADTGNNRIQKFTSTGT 188
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 108-163 3.80e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 38.84  E-value: 3.80e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 492255741 108 FDRTGKFITNIGSYGQGPNEYLNTYAEQLDeANNRIYILPWQSSKILVFDLKGNAL 163
Cdd:cd05819  128 FDPDGEFLTTFGSGGSGPGQFNGPTGVAVD-SDGNIYVADTGNHRIQVFDPDGNFL 182
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 108-163 7.60e-03

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 37.94  E-value: 7.60e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 492255741 108 FDRTGKFITNIGSYGQGPNEYLNTYAEQLDEANNrIYILPWQSSKILVFDLKGNAL 163
Cdd:cd14955  183 FTSTGTFLTKWGSEGSGDGQFNAPYGIAVDSAGN-VYVADTGNNRIQKFDSSGTFI 237
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 106-164 7.82e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 37.65  E-value: 7.82e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 492255741 106 KLFDRTGKFITNIGSYGQGPNEYLNTYAEQLDeANNRIYILPWQSSKILVFDLKGNALD 164
Cdd:cd14956   84 QVFTLTGELQTIGGSSGSGPGQFNAPRGVAVD-ADGNLYVADFGNQRIQKFDPDGSFLR 141
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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