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Conserved domains on  [gi|491956532|ref|WP_005690684|]
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MULTISPECIES: UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase [Haemophilus]

Protein Classification

Mur ligase family protein( domain architecture ID 11433699)

Mur ligase family protein similar to UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase (MurD) and UDP-N-acetylmuramoyl-L-alanine--L-glutamate ligase (MurD2), which catalyze the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)

CATH:  3.40.1190.10|3.90.190.20|3.40.50.720
EC:  6.3.2.-
Gene Ontology:  GO:0008764|GO:0005524

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
MurD COG0771
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ...
 4-434 0e+00

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis


:

Pssm-ID: 440534 [Multi-domain]  Cd Length: 445  Bit Score: 568.17  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532   4 YQNKNITIIGLGKTGLSCVDYLLSQQANIRVIDTRKKPTGID-KLPQ-NIPLHTGSLNQEWLLESDMIVISPGLAVKTPE 81
Cdd:COG0771    2 LKGKKVLVLGLGKSGLAAARLLAKLGAEVTVSDDRPAPELAAaELEApGVEVVLGEHPEELLDGADLVVKSPGIPPDHPL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532  82 IQTALKAGVEVIGDIELFCRAATKPIVGITGSNGKSTVTTLVYEMAKAAGVKVGMGGNIGIPALSLLNEDC--ELYVLEL 159
Cdd:COG0771   82 LKAARAAGIPVIGEIELAYRLSPAPIIAITGTNGKTTTTTLIGHILKAAGLRVAVGGNIGTPLLDLLLEPEppDVYVLEL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 160 SSFQLETTYSLKAAAATVLNVTEDHMDRYMDLEDYRQAKLRIYHNAEVG---VLNNEDKLTFGEGENQARQTVSF---AE 233
Cdd:COG0771  162 SSFQLETTPSLRPDVAVILNITPDHLDRHGSMEAYAAAKARIFANQTPDdyaVLNADDPLTRALAEEAKARVVPFslkEP 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 234 NSADYWLktENGKQYLMVKDEVILPCEEVTLVGRHNYMNILAATALAQAVGINLDSIRTALRHFKGLDHRFQLVHQANGI 313
Cdd:COG0771  242 LEGGAGL--EDGKLVDRASGEELLPVDDLRLPGRHNLENALAALAAARALGVPPEAIREALRSFKGLPHRLEFVAEINGV 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 314 RWINDSKATNVGSTVAALAGLyiEGKLHLLLGGDGKGADFSELAELINQPHIICYCFGRDGVQLAKFSSQS----YLFET 389
Cdd:COG0771  320 RFINDSKATNPDATLAALESF--DGPVVLIAGGLDKGADFSPLAPAVAERVKAVVLIGEDAEKIAAALAGAgvpvVIVET 397

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*
gi 491956532 390 MEQAIEFLRPTLQSGDMVLLSPACASLDQFASFEKRGEEFTHLAQ 434
Cdd:COG0771  398 MEEAVAAAAELARPGDVVLLSPACASFDQFKNYEERGDVFKEAVR 442
 
Name Accession Description Interval E-value
MurD COG0771
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ...
 4-434 0e+00

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440534 [Multi-domain]  Cd Length: 445  Bit Score: 568.17  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532   4 YQNKNITIIGLGKTGLSCVDYLLSQQANIRVIDTRKKPTGID-KLPQ-NIPLHTGSLNQEWLLESDMIVISPGLAVKTPE 81
Cdd:COG0771    2 LKGKKVLVLGLGKSGLAAARLLAKLGAEVTVSDDRPAPELAAaELEApGVEVVLGEHPEELLDGADLVVKSPGIPPDHPL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532  82 IQTALKAGVEVIGDIELFCRAATKPIVGITGSNGKSTVTTLVYEMAKAAGVKVGMGGNIGIPALSLLNEDC--ELYVLEL 159
Cdd:COG0771   82 LKAARAAGIPVIGEIELAYRLSPAPIIAITGTNGKTTTTTLIGHILKAAGLRVAVGGNIGTPLLDLLLEPEppDVYVLEL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 160 SSFQLETTYSLKAAAATVLNVTEDHMDRYMDLEDYRQAKLRIYHNAEVG---VLNNEDKLTFGEGENQARQTVSF---AE 233
Cdd:COG0771  162 SSFQLETTPSLRPDVAVILNITPDHLDRHGSMEAYAAAKARIFANQTPDdyaVLNADDPLTRALAEEAKARVVPFslkEP 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 234 NSADYWLktENGKQYLMVKDEVILPCEEVTLVGRHNYMNILAATALAQAVGINLDSIRTALRHFKGLDHRFQLVHQANGI 313
Cdd:COG0771  242 LEGGAGL--EDGKLVDRASGEELLPVDDLRLPGRHNLENALAALAAARALGVPPEAIREALRSFKGLPHRLEFVAEINGV 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 314 RWINDSKATNVGSTVAALAGLyiEGKLHLLLGGDGKGADFSELAELINQPHIICYCFGRDGVQLAKFSSQS----YLFET 389
Cdd:COG0771  320 RFINDSKATNPDATLAALESF--DGPVVLIAGGLDKGADFSPLAPAVAERVKAVVLIGEDAEKIAAALAGAgvpvVIVET 397

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*
gi 491956532 390 MEQAIEFLRPTLQSGDMVLLSPACASLDQFASFEKRGEEFTHLAQ 434
Cdd:COG0771  398 MEEAVAAAAELARPGDVVLLSPACASFDQFKNYEERGDVFKEAVR 442
murD TIGR01087
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ...
 8-434 0e+00

UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273436 [Multi-domain]  Cd Length: 433  Bit Score: 553.10  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532    8 NITIIGLGKTGLSCVDYLLSQQANIRVID-----TRKKPTGIDKLPQNIPLHTGsLNQEWLLESDMIVISPGLAVKTPEI 82
Cdd:TIGR01087   1 KILILGLGKTGRAVARFLHKKGAEVTVTDlkpneELEPSMGQLRLNEGSVLHTG-LHLEDLNNADLVVKSPGIPPDHPLV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532   83 QTALKAGVEVIGDIELFCRAATKPIVGITGSNGKSTVTTLVYEMAKAAGVKVGMGGNIGIPALSLLN-EDCELYVLELSS 161
Cdd:TIGR01087  80 QAAAKRGIPVVGDIELFLRLVPLPVVAITGTNGKTTTTSLLYHLLKAAGLKAFLGGNIGTPALEVLDqEGAELYVLELSS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532  162 FQLETTYSLKAAAATVLNVTEDHMDRYMDLEDYRQAKLRIYHNA---EVGVLNNEDK-LTFGEGENQARQTVSFAENSAD 237
Cdd:TIGR01087 160 FQLETTESLRPEIALILNISEDHLDWHGSFEDYVAAKLKIFARQtegDVAVLNADDPrFARLAQKSKAQVIWFSVEKDAE 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532  238 YWLKTENGKQYLMVKDevilpcEEVTLVGRHNYMNILAATALAQAVGINLDSIRTALRHFKGLDHRFQLVHQANGIRWIN 317
Cdd:TIGR01087 240 RGLCIRDGGLYLKPND------LEGSLLGLHNAENILAAIALAKSLGLNLEAILEALRSFKGLPHRLEYVGQKNGVHFYN 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532  318 DSKATNVGSTVAALAGLYIegKLHLLLGGDGKGADFSELAELINQPHIICYCFGRDGVQLAKFSSQS----YLFETMEQA 393
Cdd:TIGR01087 314 DSKATNVHATLAALSAFDN--PVILIVGGDDKGADFSPLAPAAAGKVKAVLAIGEDAAKIAPLLKEAglsvYLVESLEEA 391

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 491956532  394 IEFLRPTLQSGDMVLLSPACASLDQFASFEKRGEEFTHLAQ 434
Cdd:TIGR01087 392 VQAAREVASPGDVVLLSPACASFDQFKSYEERGEKFKELVR 432
murD PRK14106
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
 1-429 3.77e-107

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional


Pssm-ID: 184511 [Multi-domain]  Cd Length: 450  Bit Score: 324.23  E-value: 3.77e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532   1 MNaYQNKNITIIGLGKTGLSCVDYLLSQQANIRVIDTRKK---PTGIDKLPQ-NIPLHTGSLNQEWLLESDMIVISPGLA 76
Cdd:PRK14106   1 ME-LKGKKVLVVGAGVSGLALAKFLKKLGAKVILTDEKEEdqlKEALEELGElGIELVLGEYPEEFLEGVDLVVVSPGVP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532  77 VKTPEIQTALKAGVEVIGDIELFCRAATKPIVGITGSNGKSTVTTLVYEMAKAAGVKVGMGGNIGIP----ALSLLNEDc 152
Cdd:PRK14106  80 LDSPPVVQAHKKGIEVIGEVELAYRFSKAPIVAITGTNGKTTTTTLLGEIFKNAGRKTLVAGNIGYPlidaVEEYGEDD- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 153 eLYVLELSSFQLETTYSLKAAAATVLNVTEDHMDRYMDLEDYRQAKLRIYHN---AEVGVLNNEDKLTFGEGENQARQTV 229
Cdd:PRK14106 159 -IIVAEVSSFQLETIKEFKPKVGCILNITPDHLDRHKTMENYIKAKARIFENqrpSDYTVLNYDDPRTRSLAKKAKARVI 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 230 SFA-----ENSadYWLktENGKQYLMV--KDEVILPCEEVTLVGRHNYMNILAATALAQAVGINLDSIRTALRHFKGLDH 302
Cdd:PRK14106 238 FFSrksllEEG--VFV--KNGKIVISLggKEEEVIDIDEIFIPGEHNLENALAATAAAYLLGISPDVIANTLKTFKGVEH 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 303 RFQLVHQANGIRWINDSKATNVGSTVAALAGLyiEGKLHLLLGGDGKGADFSELAELINQP--HIICYCFGRDGV--QLA 378
Cdd:PRK14106 314 RIEFVAEINGVKFINDSKGTNPDAAIKALEAY--ETPIVLIAGGYDKGSDFDEFAKAFKEKvkKLILLGETAQEIaeAAR 391

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|..
gi 491956532 379 KFSSQSYLF-ETMEQAIEFLRPTLQSGDMVLLSPACASLDQFASFEKRGEEF 429
Cdd:PRK14106 392 KYGFDNILFaETLEEAVKKAYEIAKPGDVVLLSPACASWDMFKNFEERGRLF 443
Mur_ligase_M pfam08245
Mur ligase middle domain;
110-280 1.97e-29

Mur ligase middle domain;


Pssm-ID: 462409 [Multi-domain]  Cd Length: 199  Bit Score: 113.55  E-value: 1.97e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532  110 ITGSNGKSTVTTLVYEMAKAAGVKVGMGGN------------IGIPAL--SLLNEDCELYVLELSSFQLE---TTYSLKA 172
Cdd:pfam08245   1 VTGTNGKTTTTELIAAILSLAGGVIGTIGTyigksgnttnnaIGLPLTlaEMVEAGAEYAVLEVSSHGLGegrLSGLLKP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532  173 AAATVLNVTEDHMDRYMDLEDYRQAKLRIY---HNAEVGVLNNEDKLT---FGEGENQARQTVSFAENS-ADYWLK---- 241
Cdd:pfam08245  81 DIAVFTNISPDHLDFHGTMENYAKAKAELFeglPEDGIAVINADDPYGaflIAKLKKAGVRVITYGIEGeADLRAAniel 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 491956532  242 TENGKQY-LMVKDEVILPCeEVTLVGRHNYMNILAATALA 280
Cdd:pfam08245 161 SSDGTSFdLFTVPGGELEI-EIPLLGRHNVYNALAAIAAA 199
 
Name Accession Description Interval E-value
MurD COG0771
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ...
 4-434 0e+00

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440534 [Multi-domain]  Cd Length: 445  Bit Score: 568.17  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532   4 YQNKNITIIGLGKTGLSCVDYLLSQQANIRVIDTRKKPTGID-KLPQ-NIPLHTGSLNQEWLLESDMIVISPGLAVKTPE 81
Cdd:COG0771    2 LKGKKVLVLGLGKSGLAAARLLAKLGAEVTVSDDRPAPELAAaELEApGVEVVLGEHPEELLDGADLVVKSPGIPPDHPL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532  82 IQTALKAGVEVIGDIELFCRAATKPIVGITGSNGKSTVTTLVYEMAKAAGVKVGMGGNIGIPALSLLNEDC--ELYVLEL 159
Cdd:COG0771   82 LKAARAAGIPVIGEIELAYRLSPAPIIAITGTNGKTTTTTLIGHILKAAGLRVAVGGNIGTPLLDLLLEPEppDVYVLEL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 160 SSFQLETTYSLKAAAATVLNVTEDHMDRYMDLEDYRQAKLRIYHNAEVG---VLNNEDKLTFGEGENQARQTVSF---AE 233
Cdd:COG0771  162 SSFQLETTPSLRPDVAVILNITPDHLDRHGSMEAYAAAKARIFANQTPDdyaVLNADDPLTRALAEEAKARVVPFslkEP 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 234 NSADYWLktENGKQYLMVKDEVILPCEEVTLVGRHNYMNILAATALAQAVGINLDSIRTALRHFKGLDHRFQLVHQANGI 313
Cdd:COG0771  242 LEGGAGL--EDGKLVDRASGEELLPVDDLRLPGRHNLENALAALAAARALGVPPEAIREALRSFKGLPHRLEFVAEINGV 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 314 RWINDSKATNVGSTVAALAGLyiEGKLHLLLGGDGKGADFSELAELINQPHIICYCFGRDGVQLAKFSSQS----YLFET 389
Cdd:COG0771  320 RFINDSKATNPDATLAALESF--DGPVVLIAGGLDKGADFSPLAPAVAERVKAVVLIGEDAEKIAAALAGAgvpvVIVET 397

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*
gi 491956532 390 MEQAIEFLRPTLQSGDMVLLSPACASLDQFASFEKRGEEFTHLAQ 434
Cdd:COG0771  398 MEEAVAAAAELARPGDVVLLSPACASFDQFKNYEERGDVFKEAVR 442
murD TIGR01087
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ...
 8-434 0e+00

UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273436 [Multi-domain]  Cd Length: 433  Bit Score: 553.10  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532    8 NITIIGLGKTGLSCVDYLLSQQANIRVID-----TRKKPTGIDKLPQNIPLHTGsLNQEWLLESDMIVISPGLAVKTPEI 82
Cdd:TIGR01087   1 KILILGLGKTGRAVARFLHKKGAEVTVTDlkpneELEPSMGQLRLNEGSVLHTG-LHLEDLNNADLVVKSPGIPPDHPLV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532   83 QTALKAGVEVIGDIELFCRAATKPIVGITGSNGKSTVTTLVYEMAKAAGVKVGMGGNIGIPALSLLN-EDCELYVLELSS 161
Cdd:TIGR01087  80 QAAAKRGIPVVGDIELFLRLVPLPVVAITGTNGKTTTTSLLYHLLKAAGLKAFLGGNIGTPALEVLDqEGAELYVLELSS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532  162 FQLETTYSLKAAAATVLNVTEDHMDRYMDLEDYRQAKLRIYHNA---EVGVLNNEDK-LTFGEGENQARQTVSFAENSAD 237
Cdd:TIGR01087 160 FQLETTESLRPEIALILNISEDHLDWHGSFEDYVAAKLKIFARQtegDVAVLNADDPrFARLAQKSKAQVIWFSVEKDAE 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532  238 YWLKTENGKQYLMVKDevilpcEEVTLVGRHNYMNILAATALAQAVGINLDSIRTALRHFKGLDHRFQLVHQANGIRWIN 317
Cdd:TIGR01087 240 RGLCIRDGGLYLKPND------LEGSLLGLHNAENILAAIALAKSLGLNLEAILEALRSFKGLPHRLEYVGQKNGVHFYN 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532  318 DSKATNVGSTVAALAGLYIegKLHLLLGGDGKGADFSELAELINQPHIICYCFGRDGVQLAKFSSQS----YLFETMEQA 393
Cdd:TIGR01087 314 DSKATNVHATLAALSAFDN--PVILIVGGDDKGADFSPLAPAAAGKVKAVLAIGEDAAKIAPLLKEAglsvYLVESLEEA 391

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 491956532  394 IEFLRPTLQSGDMVLLSPACASLDQFASFEKRGEEFTHLAQ 434
Cdd:TIGR01087 392 VQAAREVASPGDVVLLSPACASFDQFKSYEERGEKFKELVR 432
murD PRK14106
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
 1-429 3.77e-107

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional


Pssm-ID: 184511 [Multi-domain]  Cd Length: 450  Bit Score: 324.23  E-value: 3.77e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532   1 MNaYQNKNITIIGLGKTGLSCVDYLLSQQANIRVIDTRKK---PTGIDKLPQ-NIPLHTGSLNQEWLLESDMIVISPGLA 76
Cdd:PRK14106   1 ME-LKGKKVLVVGAGVSGLALAKFLKKLGAKVILTDEKEEdqlKEALEELGElGIELVLGEYPEEFLEGVDLVVVSPGVP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532  77 VKTPEIQTALKAGVEVIGDIELFCRAATKPIVGITGSNGKSTVTTLVYEMAKAAGVKVGMGGNIGIP----ALSLLNEDc 152
Cdd:PRK14106  80 LDSPPVVQAHKKGIEVIGEVELAYRFSKAPIVAITGTNGKTTTTTLLGEIFKNAGRKTLVAGNIGYPlidaVEEYGEDD- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 153 eLYVLELSSFQLETTYSLKAAAATVLNVTEDHMDRYMDLEDYRQAKLRIYHN---AEVGVLNNEDKLTFGEGENQARQTV 229
Cdd:PRK14106 159 -IIVAEVSSFQLETIKEFKPKVGCILNITPDHLDRHKTMENYIKAKARIFENqrpSDYTVLNYDDPRTRSLAKKAKARVI 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 230 SFA-----ENSadYWLktENGKQYLMV--KDEVILPCEEVTLVGRHNYMNILAATALAQAVGINLDSIRTALRHFKGLDH 302
Cdd:PRK14106 238 FFSrksllEEG--VFV--KNGKIVISLggKEEEVIDIDEIFIPGEHNLENALAATAAAYLLGISPDVIANTLKTFKGVEH 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 303 RFQLVHQANGIRWINDSKATNVGSTVAALAGLyiEGKLHLLLGGDGKGADFSELAELINQP--HIICYCFGRDGV--QLA 378
Cdd:PRK14106 314 RIEFVAEINGVKFINDSKGTNPDAAIKALEAY--ETPIVLIAGGYDKGSDFDEFAKAFKEKvkKLILLGETAQEIaeAAR 391

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|..
gi 491956532 379 KFSSQSYLF-ETMEQAIEFLRPTLQSGDMVLLSPACASLDQFASFEKRGEEF 429
Cdd:PRK14106 392 KYGFDNILFaETLEEAVKKAYEIAKPGDVVLLSPACASWDMFKNFEERGRLF 443
MurF COG0770
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 106-409 9.40e-36

UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440533 [Multi-domain]  Cd Length: 451  Bit Score: 137.16  E-value: 9.40e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 106 PIVGITGSNGKSTVTTLVYEMAKAAGVKVGMGGN----IGIPaLSLL--NEDCELYVLELS-SFQLETTYSLKAA---AA 175
Cdd:COG0770  101 PVIAITGSNGKTTTKEMLAAVLSTKGKVLATPGNfnneIGVP-LTLLrlPEDHEFAVLEMGmNHPGEIAYLARIArpdIA 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 176 TVLNVTEDHMDRYMDLEDYRQAKLRIYHNAE---VGVLNNEDKLTFGEGENQARQTVSFAEN-SADYWLK----TENGKQ 247
Cdd:COG0770  180 VITNIGPAHLEGFGSLEGIARAKGEIFEGLPpggVAVLNADDPLLAALAERAKARVLTFGLSeDADVRAEdielDEDGTR 259

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 248 YlmvkdEVILPCEEVT----LVGRHNYMNILAATALAQAVGINLDSIRTALRHFKGLDHRFQLVHQANGIRWINDS-KAt 322
Cdd:COG0770  260 F-----TLHTPGGELEvtlpLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKGRLEVIEGAGGVTLIDDSyNA- 333

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 323 NVGSTVAA---LAGLYIEGKLHLLLG-----GDGKGADFSELAELINQPHI-ICYCFGRDGVQLAK--FSSQSYLFETME 391
Cdd:COG0770  334 NPDSMKAAldvLAQLPGGGRRIAVLGdmlelGEESEELHREVGELAAELGIdRLFTVGELARAIAEaaGGERAEHFEDKE 413

                        330
                 ....*....|....*...
gi 491956532 392 QAIEFLRPTLQSGDMVLL 409
Cdd:COG0770  414 ELLAALKALLRPGDVVLV 431
Mur_ligase_M pfam08245
Mur ligase middle domain;
110-280 1.97e-29

Mur ligase middle domain;


Pssm-ID: 462409 [Multi-domain]  Cd Length: 199  Bit Score: 113.55  E-value: 1.97e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532  110 ITGSNGKSTVTTLVYEMAKAAGVKVGMGGN------------IGIPAL--SLLNEDCELYVLELSSFQLE---TTYSLKA 172
Cdd:pfam08245   1 VTGTNGKTTTTELIAAILSLAGGVIGTIGTyigksgnttnnaIGLPLTlaEMVEAGAEYAVLEVSSHGLGegrLSGLLKP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532  173 AAATVLNVTEDHMDRYMDLEDYRQAKLRIY---HNAEVGVLNNEDKLT---FGEGENQARQTVSFAENS-ADYWLK---- 241
Cdd:pfam08245  81 DIAVFTNISPDHLDFHGTMENYAKAKAELFeglPEDGIAVINADDPYGaflIAKLKKAGVRVITYGIEGeADLRAAniel 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 491956532  242 TENGKQY-LMVKDEVILPCeEVTLVGRHNYMNILAATALA 280
Cdd:pfam08245 161 SSDGTSFdLFTVPGGELEI-EIPLLGRHNVYNALAAIAAA 199
MurE COG0769
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 107-348 8.28e-29

UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440532 [Multi-domain]  Cd Length: 459  Bit Score: 117.49  E-value: 8.28e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 107 IVGITGSNGKSTVTTLVYEMAKAAGVKVGMGGNIGI-------------P-ALSL-------LNEDCELYVLELSSFQLE 165
Cdd:COG0769   82 LIGVTGTNGKTTTTYLLAQILRALGKKTGLIGTVGNgiggelipsslttPeALDLqrllaemVDAGVTHVVMEVSSHALD 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 166 T--TYSLKAAAATVLNVTEDHMDRYMDLEDYRQAKLRI---YHNAEVGVLNNEDKltFGE--GENQARQTVSFA-ENSAD 237
Cdd:COG0769  162 QgrVDGVRFDVAVFTNLTRDHLDYHGTMEAYFAAKARLfdqLGPGGAAVINADDP--YGRrlAAAAPARVITYGlKADAD 239

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 238 YWLK----TENGKQYlmvkdEVILPCEEVT----LVGRHNYMNILAATALAQAVGINLDSIRTALRHFKGLDHRFQLVHQ 309
Cdd:COG0769  240 LRATdielSADGTRF-----TLVTPGGEVEvrlpLIGRFNVYNALAAIAAALALGIDLEEILAALEKLKGVPGRMERVDG 314

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 491956532 310 ANGIRWINDSKAT-----NVGSTVAALAGlyieGKLHLLLGGDG 348
Cdd:COG0769  315 GQGPTVIVDYAHTpdaleNVLEALRPHTK----GRLIVVFGCGG 354
murE PRK00139
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
 107-313 8.55e-29

UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional


Pssm-ID: 234660 [Multi-domain]  Cd Length: 460  Bit Score: 117.54  E-value: 8.55e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 107 IVGITGSNGKSTVTTLVYEMAKAAGVKVGMGGNIGI--------------PALSL-------LNEDCELYVLELSSFQLE 165
Cdd:PRK00139  97 LIGVTGTNGKTTTAYLLAQILRLLGEKTALIGTLGNgiggelipsglttpDALDLqrllaelVDAGVTYAAMEVSSHALD 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 166 T--TYSLKAAAATVLNVTEDHMDRYMDLEDYRQAKLRIYHNAEV-GVLNNEDKltFGEGENQARQTVSFAENSADYWLK- 241
Cdd:PRK00139 177 QgrVDGLKFDVAVFTNLSRDHLDYHGTMEDYLAAKARLFSELGLaAVINADDE--VGRRLLALPDAYAVSMAGADLRATd 254

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491956532 242 ---TENGkQYLMVKDEVILPceevtLVGRHNYMNILAATALAQAVGINLDSIRTALRHFKGLDHRFQLVHQANGI 313
Cdd:PRK00139 255 veyTDSG-QTFTLVTEVESP-----LIGRFNVSNLLAALAALLALGVPLEDALAALAKLQGVPGRMERVDAGQGP 323
murF TIGR01143
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ...
 106-409 3.93e-28

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273468 [Multi-domain]  Cd Length: 417  Bit Score: 115.06  E-value: 3.93e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532  106 PIVGITGSNGKSTVTTLVYEMAKAAGVKVGMGGN----IGIPaLSLLN--EDCELYVLELS-SFQLETTYSLKAA---AA 175
Cdd:TIGR01143  75 KVIGITGSSGKTTTKEMLAAILSHKYKVFATPGNfnneIGLP-LTLLRapGDHDYAVLEMGaSHPGEIAYLAEIAkpdIA 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532  176 TVLNVTEDHMDRYMDLEDYRQAKLRIY----HNAeVGVLNNEDK-LTFGEGENQARQTVSFAENSADYWLKTENGKQYLM 250
Cdd:TIGR01143 154 VITNIGPAHLEGFGSLEGIAEAKGEILqglkENG-IAVINADDPaFADLAKRLPNRNILSFGFEGGDFVAKDISYSALGS 232

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532  251 VKDEVILPCEEVT----LVGRHNYMNILAATALAQAVGINLDSIRTALRHFKGLDHRFQLVHqANGIRWINDSKATNVGS 326
Cdd:TIGR01143 233 TSFTLVAPGGEFEvslpLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKLVKGRFEVQT-KNGLTLIDDTYNANPDS 311

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532  327 TVAAL-AGLYIEGKLHLLLGgdgkgaDFSELAELINQPHIIC------------YCFGRDGVQLAK-FSSQSYLFETMEQ 392
Cdd:TIGR01143 312 MRAALdALARFPGKKILVLG------DMAELGEYSEELHAEVgryanslgidlvFLVGEEAAVIYDsFGKQGKHFADKDE 385

                         330
                  ....*....|....*..
gi 491956532  393 AIEFLRPTLQSGDMVLL 409
Cdd:TIGR01143 386 LLAFLKTLVRKGDVVLV 402
MurC COG0773
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ...
 49-408 1.45e-26

UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440536 [Multi-domain]  Cd Length: 451  Bit Score: 110.93  E-value: 1.45e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532  49 QNIPLHTGSlNQEWLLESDMIVISPglAVKT--PEIQTALKAGVEVI------GDIelfcrAATKPIVGITGSNGKSTVT 120
Cdd:COG0773   48 LGIPVFIGH-DAENIDDADLVVVSS--AIPRdnPELVAARERGIPVLsraemlAEL-----MRGKRSIAVAGTHGKTTTT 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 121 TLVYEMAKAAGVKVG--MGG---NIGIPALslLNEDcELYVLE----LSSFQLettysLKAAAATVLNVTEDHMDRYMDL 191
Cdd:COG0773  120 SMLAHILEEAGLDPTflIGGilnNFGTNAR--LGDG-DYFVAEadesDGSFLH-----YSPDIAVVTNIEADHLDIYGDL 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 192 EDYRQAKLRIYHNAEVG---VLNNEDKLTFGEGENQARQTVSFAEN-SADYWLK----TENGKQY-LMVKDEVILPCEeV 262
Cdd:COG0773  192 EAIKEAFHEFARNVPFYgllVLCADDPGLRELLPRCGRPVITYGFSeDADYRAEniriDGGGSTFdVLRRGEELGEVE-L 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 263 TLVGRHNYMNILAATALAQAVGINLDSIRTALRHFKGLDHRFQLVHQANGIRWIND-----SKatnVGSTVAALAGLYIE 337
Cdd:COG0773  271 NLPGRHNVLNALAAIAVALELGVDPEAIAEALASFKGVKRRFELKGEVGGVTVIDDyahhpTE---IAATLAAAREKYPD 347

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 338 GKLHLLLggdgkgadfselaelinQPH----------------------IICYCFG-----RDGV-------QLAKFSSQ 383
Cdd:COG0773  348 RRLVAVF-----------------QPHrysrtrdfldefaealsladevILLDIYAarekpIPGVssedlaeAIRKRGKD 410

                        410       420
                 ....*....|....*....|....*
gi 491956532 384 SYLFETMEQAIEFLRPTLQSGDMVL 408
Cdd:COG0773  411 VVYVPDLDELVEALAEIARPGDVVL 435
murC TIGR01082
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial ...
 8-408 7.68e-25

UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial peptidoglycan (murein) biosynthesis. In a few species (Mycobacterium leprae, the Chlamydia), the amino acid may be L-serine or glycine instead of L-alanine. A related protein, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (murein tripeptide ligase) is described by model TIGR01081. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273433 [Multi-domain]  Cd Length: 448  Bit Score: 106.24  E-value: 7.68e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532    8 NITIIGLGKTGLSCV-DYLLSQQANIRVIDTRKKPTgIDKLPQ-NIPLHTGSLNQEWLlESDMIVISPglAVK--TPEIQ 83
Cdd:TIGR01082   1 KIHFVGIGGIGMSGIaEILLNRGYQVSGSDIAENAT-TKRLEAlGIPIYIGHSAENLD-DADVVVVSA--AIKddNPEIV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532   84 TALKAGVEVI--GDI--ELFCRaatKPIVGITGSNGKSTVTTLVYEMAKAAGVK--VGMGGNIGipalsLLNEDC----- 152
Cdd:TIGR01082  77 EAKERGIPVIrrAEMlaELMRF---RHSIAVAGTHGKTTTTAMIAVILKEAGLDptVVVGGLVK-----EAGTNArlgsg 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532  153 ELYVLEL----SSFqlettYSLKAAAATVLNVTEDHMDRYM-DLEDYRQAKLRIYHNAEVG---VLNNEDKLTFGEGENQ 224
Cdd:TIGR01082 149 EYLVAEAdesdASF-----LHLQPNVAIVTNIEPDHLDTYGsSFERLKAAFEKFIHNLPFYglaVICADDPVLRELVPKA 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532  225 ARQTVSFAENSADYWLKTEN-----GKQYLMVKDEVILPCEE-VTLVGRHNYMNILAATALAQAVGINLDSIRTALRHFK 298
Cdd:TIGR01082 224 TEQVITYGGSGEDADYRAENiqqsgAEGKFSVRGKGKLYLEFtLNLPGRHNVLNALAAIAVALELGIDFEAILRALANFQ 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532  299 GLDHRFQLVHQANGIRWIND--SKATNVGSTVAALAGLYIEGKL------------HLLLGGDGK--------------- 349
Cdd:TIGR01082 304 GVKRRFEILGEFGGVLLIDDyaHHPTEIKATLKAARQGYPDKRIvvvfqphrysrtRDLFDDFAKvlsdadelilldiya 383

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491956532  350 -------GADFSELAELINQPHIIcycfgrdgvqlakfssQSYLFETMEQAIEFLRPTLQSGDMVL 408
Cdd:TIGR01082 384 ageepinGIDGKSLARKITQLGKI----------------EPYFVPDLAELVEFLAAVLQSGDLIL 433
murE TIGR01085
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ...
 107-318 1.65e-22

UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273435 [Multi-domain]  Cd Length: 464  Bit Score: 99.31  E-value: 1.65e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532  107 IVGITGSNGKSTVTTLVYEMAKAAGVKVGMGGNIG--IPALSLLNED----------------------CELYVLELSSF 162
Cdd:TIGR01085  87 VIGVTGTNGKTTTTSLIAQLLRLLGKKTGLIGTIGyrLGGNDLIKNPaalttpealtlqstlaemveagAQYAVMEVSSH 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532  163 QLET--TYSLKAAAATVLNVTEDHMDRYMDLEDYRQAKLRIY--HNAEV-GVLNNEDKLT--FgEGENQARQTVSFAENS 235
Cdd:TIGR01085 167 ALAQgrVRGVRFDAAVFTNLSRDHLDFHGTMENYFAAKASLFteLGLKRfAVINLDDEYGaqF-VKRLPKDITVSAITQP 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532  236 ADYWLKT---------ENGKQYLMVKDEVILPCeEVTLVGRHNYMNILAATALA-QAVGINLDSIRTALRHFKGLDHRFQ 305
Cdd:TIGR01085 246 ADGRAQDikitdsgysFEGQQFTFETPAGEGHL-HTPLIGRFNVYNLLAALATLlHLGGIDLEDIVAALEKFRGVPGRME 324

                         250
                  ....*....|...
gi 491956532  306 LVHQANGIRWIND 318
Cdd:TIGR01085 325 LVDGGQKFLVIVD 337
PRK11929 PRK11929
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ...
 104-408 9.55e-21

bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;


Pssm-ID: 237025 [Multi-domain]  Cd Length: 958  Bit Score: 95.16  E-value: 9.55e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 104 TKPIVGITGSNGKSTVTTLVyemAKAAGVKVGMG------GN----IGIPaLSLLN--EDCELYVLELSSFQL-ETTYSL 170
Cdd:PRK11929 602 SLPVVAITGSNGKTTTKEMI---AAILAAWQGEDrvlateGNfnneIGVP-LTLLRlrAQHRAAVFELGMNHPgEIAYLA 677

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 171 KAAAATV---LNVTEDHMDRYMDLEDYRQAKLRIYHNAE---VGVLNNEDK-----LTFGEGENQARQTVSFAENS-ADY 238
Cdd:PRK11929 678 AIAAPTValvTNAQREHQEFMHSVEAVARAKGEIIAALPedgVAVVNGDDPytaiwAKLAGARRVLRFGLQPGADVyAEK 757

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 239 WLKTENGKQYLMVKDEVILPCE--EVTL--VGRHNYMNILAATALAQAVGINLDSIRTALRHFKGLDHRFQLVHQANGIR 314
Cdd:PRK11929 758 IAKDISVGEAGGTRCQVVTPAGsaEVYLplIGEHNLRNALAAIACALAAGASLKQIRAGLERFQPVAGRMQRRRLSCGTR 837

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 315 WINDSKATN---VGSTVAALAGLYIEGKLhLLLGGDGKGADFS-----ELAELINQPHI-ICYCFGRDGVQLAKFSSQSY 385
Cdd:PRK11929 838 IIDDTYNANpdsMRAAIDVLAELPNGPRA-LVLGDMLELGDNGpamhrEVGKYARQLGIdALITLGEAARDAAAAFGAGA 916

                        330       340
                 ....*....|....*....|....*
gi 491956532 386 L--FETMEQAIEFLRPTLQSGDMVL 408
Cdd:PRK11929 917 RgvCASVDEIIAALRGALPEGDSVL 941
PRK11929 PRK11929
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ...
 66-307 4.32e-19

bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;


Pssm-ID: 237025 [Multi-domain]  Cd Length: 958  Bit Score: 90.15  E-value: 4.32e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532  66 SDMIVISPGLAVKTPEIQTALKagvevigdiELFCRAATKP-----IVGITGSNGKSTVTTLVYEMAKAAGVKVGMGGNI 140
Cdd:PRK11929  77 EDQVAAADALVLPVADLRKALG---------ELAARWYGRPseqlsLVAVTGTNGKTSCAQLLAQLLTRLGKPCGSIGTL 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 141 G-------IP-------ALSL---LNE----DCELYVLELSSFQLETT--YSLKAAAATVLNVTEDHMDRYMDLEDYRQA 197
Cdd:PRK11929 148 GarldgrlIPgslttpdAIILhriLARmraaGADAVAMEASSHGLEQGrlDGLRIAVAGFTNLTRDHLDYHGTMQDYEEA 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 198 KLRIY---HNAEVGVLNNEDKltfgEGENQAR------QTVSFAENSADYW----LKTENGKQYLMVKDevilPCEEVT- 263
Cdd:PRK11929 228 KAALFsklPGLGAAVINADDP----AAARLLAalprglKVGYSPQNAGADVqardLRATAHGQVFTLAT----PDGSYQl 299

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 491956532 264 ---LVGRHNYMNILAATALAQAVGINLDSIRTALRHFKGLDHRFQLV 307
Cdd:PRK11929 300 vtrLLGRFNVSNLLLVAAALKKLGLPLAQIARALAAVSPVPGRMERV 346
murF PRK10773
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed
 107-330 3.48e-14

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed


Pssm-ID: 182718 [Multi-domain]  Cd Length: 453  Bit Score: 73.91  E-value: 3.48e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 107 IVGITGSNGKstvtTLVYEMAKA----AGVKVGMGGN----IGIPaLSL--LNEDCELYVLEL-SSFQLETTYS---LKA 172
Cdd:PRK10773 102 VVALTGSSGK----TSVKEMTAAilrqCGNTLYTAGNlnndIGVP-LTLlrLTPEHDYAVIELgANHQGEIAYTvslTRP 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 173 AAATVLNVTEDHMDRYMDLEDYRQAKLRIYHN---AEVGVLNNE------------DKLTFGEGENQARQTVSFAEN--- 234
Cdd:PRK10773 177 EAALVNNLAAAHLEGFGSLAGVAKAKGEIFSGlpeNGIAIMNADsndwlnwqsvigSKTVWRFSPNAANSVDFTATNihv 256

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 235 ---SADYWLKTENGKQylmvkdEVILPceevtLVGRHNYMNILAATALAQAVGINLDSIRTALRHFKGLDHRFQLVHQAN 311
Cdd:PRK10773 257 tshGTEFTLHTPTGSV------DVLLP-----LPGRHNIANALAAAALAMSVGATLDAVKAGLANLKAVPGRLFPIQLAE 325

                        250
                 ....*....|....*....
gi 491956532 312 GIRWINDSKATNVGSTVAA 330
Cdd:PRK10773 326 GQLLLDDSYNANVGSMTAA 344
PRK14573 PRK14573
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;
12-305 5.86e-12

bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;


Pssm-ID: 184752 [Multi-domain]  Cd Length: 809  Bit Score: 67.92  E-value: 5.86e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532  12 IGLGKTGLSCVDY-LLSQQANIRVIDTRKKPTgIDKLPQNIPLHTGSLNQEWLLESDMIVISPGLAVKTPEIQTALKAGV 90
Cdd:PRK14573  10 IGIGGIGMSALAHiLLDRGYSVSGSDLSEGKT-VEKLKAKGARFFLGHQEEHVPEDAVVVYSSSISKDNVEYLSAKSRGN 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532  91 EVIGDIELFCRAATKPI-VGITGSNGKSTVTTLVYEMAKAAGV--KVGMGGnigipalslLNEDC--------ELYVLEL 159
Cdd:PRK14573  89 RLVHRAELLAELMQEQIsILVSGSHGKTTVSSLITAIFQEAKKdpSYAIGG---------LNQEGlngysgssEYFVAEA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 160 SsfqlETTYSLK---AAAATVLNVTEDHMDRY--------MDLEDY----RQAKLrIYHNAEVGVL-NNEDKLTFGEGEN 223
Cdd:PRK14573 160 D----ESDGSLKhytPEFSVITNIDNEHLSNFegdrelllASIQDFarkvQQINK-CFYNGDCPRLkGCLQGHSYGFSSS 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 224 QARQTVSFAENS-ADYWLKTENGKQYLMVkdevilpceEVTLVGRHNYMNILAATALAQAVGINLDSIRTALRHFKGLDH 302
Cdd:PRK14573 235 CDLHILSYYQEGwRSYFSAKFLGVVYQDI---------ELNLVGMHNVANAAAAMGIALTLGIDEGAIRNALKGFSGVQR 305


                 ...
gi 491956532 303 RFQ 305
Cdd:PRK14573 306 RLE 308
PRK14016 PRK14016
cyanophycin synthetase; Provisional
 106-297 4.59e-11

cyanophycin synthetase; Provisional


Pssm-ID: 237586 [Multi-domain]  Cd Length: 727  Bit Score: 64.79  E-value: 4.59e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 106 PIVGITGSNGKSTVTTLVYEMAKAAGVKVGMGGNIGI--------------PA---LSLLNEDCELYVLE------LSS- 161
Cdd:PRK14016 481 PIVAVTGTNGKTTTTRLIAHILKLSGKRVGMTTTDGVyidgrlidkgdctgPKsarRVLMNPDVEAAVLEtarggiLREg 560

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 162 --FQLettyslkAAAATVLNVTEDHM-DRYMD-LEDYRQAKLRIYHNAE---VGVLNNEDKLTFGEGENQARQTVSFAEN 234
Cdd:PRK14016 561 laYDR-------CDVGVVTNIGEDHLgLGGINtLEDLAKVKRVVVEAVKpdgYAVLNADDPMVAAMAERCKGKVIFFSMD 633

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491956532 235 SADYWLKT--ENGKQYLMVKD-----------EVILPCEEV--TLVGR--HNYMNILAATALAQAVGINLDSIRTALRHF 297
Cdd:PRK14016 634 PDNPVIAEhrAQGGRAVYVEGdyivlaeggweIRIISLADIplTLGGKagFNIENALAAIAAAWALGIDIELIRAGLRTF 713
Mur_ligase_C pfam02875
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ...
 302-370 2.58e-10

Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.


Pssm-ID: 460731 [Multi-domain]  Cd Length: 87  Bit Score: 56.58  E-value: 2.58e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491956532  302 HRFQLVHQANGIRWINDsKATNVGSTVAALAGL--YIEGKLHLLLGGDG-KGADFSELAELINQPHIICYCF 370
Cdd:pfam02875   3 GRLEVVGENNGVLVIDD-YAHNPDAMEAALRALrnLFPGRLILVFGGMGdRDAEFHALLGRLAAALADVVIL 73
IMS pfam00817
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
 88-136 2.96e-03

impB/mucB/samB family; These proteins are involved in UV protection (Swiss).


Pssm-ID: 425885 [Multi-domain]  Cd Length: 148  Bit Score: 37.94  E-value: 2.96e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 491956532   88 AGVEVIGDIELfcraATKPIVgITGSNGKSTVTTLVYEmAKAAGVKVGM 136
Cdd:pfam00817   8 ASVELLRDPEL----KGKPVA-VGGGNGRGIVAAASYE-ARKYGVRSGM 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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