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Conserved domains on  [gi|491954486|ref|WP_005689384|]
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bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR [Lacticaseibacillus rhamnosus]

Protein Classification

bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase( domain architecture ID 10012271)

bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA

Gene Ontology:  GO:0003723|GO:0004845|GO:0006355

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK05205 PRK05205
bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR;
3-179 4.58e-105

bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR;


:

Pssm-ID: 235365  Cd Length: 176  Bit Score: 298.58  E-value: 4.58e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491954486   3 QSKQVVDEVTMKRALTRISYEIIEQNKGLNDLVLVGIKTRGIYLAHRIAKRLEQLEGLKVPVGELDIRFYRDDVHKIDHe 82
Cdd:PRK05205   2 MKKEILDAEALRRALTRIAHEIIERNKGLDNLVLVGIKTRGVWLAERLAERLEQLEGVDVPVGELDITLYRDDLTKKGL- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491954486  83 hQPDVEGAQLPVNITGKHVILVDDVIFTGRTIRAALDALMDEGRPRKISLAVLVDRGHRELPIRPDFVGKNIPTSLDEQI 162
Cdd:PRK05205  81 -HPQVKPTDIPFDIEGKRVILVDDVLYTGRTIRAALDALFDYGRPARVQLAVLVDRGHRELPIRADYVGKNIPTSRDERV 159

                        170
                 ....*....|....*..
gi 491954486 163 QVQVAELDGKDGISIEK 179
Cdd:PRK05205 160 VVRLAEVDGRDRVVLER 176
 
Name Accession Description Interval E-value
PRK05205 PRK05205
bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR;
3-179 4.58e-105

bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR;


Pssm-ID: 235365  Cd Length: 176  Bit Score: 298.58  E-value: 4.58e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491954486   3 QSKQVVDEVTMKRALTRISYEIIEQNKGLNDLVLVGIKTRGIYLAHRIAKRLEQLEGLKVPVGELDIRFYRDDVHKIDHe 82
Cdd:PRK05205   2 MKKEILDAEALRRALTRIAHEIIERNKGLDNLVLVGIKTRGVWLAERLAERLEQLEGVDVPVGELDITLYRDDLTKKGL- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491954486  83 hQPDVEGAQLPVNITGKHVILVDDVIFTGRTIRAALDALMDEGRPRKISLAVLVDRGHRELPIRPDFVGKNIPTSLDEQI 162
Cdd:PRK05205  81 -HPQVKPTDIPFDIEGKRVILVDDVLYTGRTIRAALDALFDYGRPARVQLAVLVDRGHRELPIRADYVGKNIPTSRDERV 159

                        170
                 ....*....|....*..
gi 491954486 163 QVQVAELDGKDGISIEK 179
Cdd:PRK05205 160 VVRLAEVDGRDRVVLER 176
PyrR COG2065
Pyrimidine operon attenuation protein PyrR/uracil phosphoribosyltransferase [Nucleotide ...
 3-179 1.44e-102

Pyrimidine operon attenuation protein PyrR/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Pyrimidine operon attenuation protein PyrR/uracil phosphoribosyltransferase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 441668  Cd Length: 178  Bit Score: 292.35  E-value: 1.44e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491954486   3 QSKQVVDEVTMKRALTRISYEIIEQNKGLNDLVLVGIKTRGIYLAHRIAKRLEQLEGLKVPVGELDIRFYRDDVHKIDHe 82
Cdd:COG2065    2 KKKEILDAADIDRALTRIAHEIIERNKGLEDLVLVGIQTRGVPLAERLAERIEEIEGVKVPVGSLDITLYRDDLRRRPP- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491954486  83 hQPDVEGAQLPVNITGKHVILVDDVIFTGRTIRAALDALMDEGRPRKISLAVLVDRGHRELPIRPDFVGKNIPTSLDEQI 162
Cdd:COG2065   81 -RPVVNETEIPFDIDGKTVVLVDDVLYTGRTVRAALDALMDFGRPAKIQLAVLVDRGHRELPIRADYVGKNVPTSRSERV 159

                        170
                 ....*....|....*..
gi 491954486 163 QVQVAELDGKDGISIEK 179
Cdd:COG2065  160 EVRLKEIDGEDAVVIVE 176
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 5-161 8.94e-22

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 86.26  E-value: 8.94e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491954486    5 KQVVDEVTMKRALTRISYEIIEqNKGLNDLVLVGIKTRGIYLAHRIAKRLEqleglkVPVGELDIRFYRDDVhkidhehQ 84
Cdd:pfam00156   3 DEILDNPAILKAVARLAAQINE-DYGGKPDVVVGILRGGLPFAGILARRLD------VPLAFVRKVSYNPDT-------S 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491954486   85 PDVEGAQLPVNITGKHVILVDDVIFTGRTIRAALDALMDEGrPRKISLAVLVDRGHRELPIR------PDFVGKNIPTSL 158
Cdd:pfam00156  69 EVMKTSSALPDLKGKTVLIVDDILDTGGTLLKVLELLKNVG-PKEVKIAVLIDKPAGTEPKDkydkrvDDWIVFVVGFGL 147


                  ...
gi 491954486  159 DEQ 161
Cdd:pfam00156 148 DER 150
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 16-151 1.30e-19

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 79.75  E-value: 1.30e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491954486  16 ALTRISYEIIEqnKGLNDLVLVGIKTRGIYLAHRIAKRLeqleglKVPVGELDIRFYRDDVHKIdhehQPDVEGAQLPVN 95
Cdd:cd06223    1 AGRLLAEEIRE--DLLEPDVVVGILRGGLPLAAALARAL------GLPLAFIRKERKGPGRTPS----EPYGLELPLGGD 68

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491954486  96 ITGKHVILVDDVIFTGRTIRAALDALMDEGrPRKISLAVLVDRGHR-----ELPIRPDFVG 151
Cdd:cd06223   69 VKGKRVLLVDDVIATGGTLLAAIELLKEAG-AKVVGVAVLLDKPEGgarelASPGDPVYSL 128
 
Name Accession Description Interval E-value
PRK05205 PRK05205
bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR;
3-179 4.58e-105

bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR;


Pssm-ID: 235365  Cd Length: 176  Bit Score: 298.58  E-value: 4.58e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491954486   3 QSKQVVDEVTMKRALTRISYEIIEQNKGLNDLVLVGIKTRGIYLAHRIAKRLEQLEGLKVPVGELDIRFYRDDVHKIDHe 82
Cdd:PRK05205   2 MKKEILDAEALRRALTRIAHEIIERNKGLDNLVLVGIKTRGVWLAERLAERLEQLEGVDVPVGELDITLYRDDLTKKGL- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491954486  83 hQPDVEGAQLPVNITGKHVILVDDVIFTGRTIRAALDALMDEGRPRKISLAVLVDRGHRELPIRPDFVGKNIPTSLDEQI 162
Cdd:PRK05205  81 -HPQVKPTDIPFDIEGKRVILVDDVLYTGRTIRAALDALFDYGRPARVQLAVLVDRGHRELPIRADYVGKNIPTSRDERV 159

                        170
                 ....*....|....*..
gi 491954486 163 QVQVAELDGKDGISIEK 179
Cdd:PRK05205 160 VVRLAEVDGRDRVVLER 176
PyrR COG2065
Pyrimidine operon attenuation protein PyrR/uracil phosphoribosyltransferase [Nucleotide ...
 3-179 1.44e-102

Pyrimidine operon attenuation protein PyrR/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Pyrimidine operon attenuation protein PyrR/uracil phosphoribosyltransferase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 441668  Cd Length: 178  Bit Score: 292.35  E-value: 1.44e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491954486   3 QSKQVVDEVTMKRALTRISYEIIEQNKGLNDLVLVGIKTRGIYLAHRIAKRLEQLEGLKVPVGELDIRFYRDDVHKIDHe 82
Cdd:COG2065    2 KKKEILDAADIDRALTRIAHEIIERNKGLEDLVLVGIQTRGVPLAERLAERIEEIEGVKVPVGSLDITLYRDDLRRRPP- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491954486  83 hQPDVEGAQLPVNITGKHVILVDDVIFTGRTIRAALDALMDEGRPRKISLAVLVDRGHRELPIRPDFVGKNIPTSLDEQI 162
Cdd:COG2065   81 -RPVVNETEIPFDIDGKTVVLVDDVLYTGRTVRAALDALMDFGRPAKIQLAVLVDRGHRELPIRADYVGKNVPTSRSERV 159

                        170
                 ....*....|....*..
gi 491954486 163 QVQVAELDGKDGISIEK 179
Cdd:COG2065  160 EVRLKEIDGEDAVVIVE 176
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 5-161 8.94e-22

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 86.26  E-value: 8.94e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491954486    5 KQVVDEVTMKRALTRISYEIIEqNKGLNDLVLVGIKTRGIYLAHRIAKRLEqleglkVPVGELDIRFYRDDVhkidhehQ 84
Cdd:pfam00156   3 DEILDNPAILKAVARLAAQINE-DYGGKPDVVVGILRGGLPFAGILARRLD------VPLAFVRKVSYNPDT-------S 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491954486   85 PDVEGAQLPVNITGKHVILVDDVIFTGRTIRAALDALMDEGrPRKISLAVLVDRGHRELPIR------PDFVGKNIPTSL 158
Cdd:pfam00156  69 EVMKTSSALPDLKGKTVLIVDDILDTGGTLLKVLELLKNVG-PKEVKIAVLIDKPAGTEPKDkydkrvDDWIVFVVGFGL 147


                  ...
gi 491954486  159 DEQ 161
Cdd:pfam00156 148 DER 150
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 16-151 1.30e-19

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 79.75  E-value: 1.30e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491954486  16 ALTRISYEIIEqnKGLNDLVLVGIKTRGIYLAHRIAKRLeqleglKVPVGELDIRFYRDDVHKIdhehQPDVEGAQLPVN 95
Cdd:cd06223    1 AGRLLAEEIRE--DLLEPDVVVGILRGGLPLAAALARAL------GLPLAFIRKERKGPGRTPS----EPYGLELPLGGD 68

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491954486  96 ITGKHVILVDDVIFTGRTIRAALDALMDEGrPRKISLAVLVDRGHR-----ELPIRPDFVG 151
Cdd:cd06223   69 VKGKRVLLVDDVIATGGTLLAAIELLKEAG-AKVVGVAVLLDKPEGgarelASPGDPVYSL 128
HptA COG0634
Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; ...
 92-155 2.49e-13

Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; Hypoxanthine-guanine phosphoribosyltransferase is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 440399  Cd Length: 176  Bit Score: 64.66  E-value: 2.49e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491954486  92 LPVNITGKHVILVDDVIFTGRTIRAALDALMDEGrPRKISLAVLVDRGH-RELPIRPDFVGKNIP 155
Cdd:COG0634   85 LDEDIEGRDVLIVEDIIDTGLTLSYLLELLKSRG-PASVKIATLLDKPErRKVDVPADYVGFEIP 148
Hpt1 COG2236
Hypoxanthine phosphoribosyltransferase [Coenzyme transport and metabolism]; Hypoxanthine ...
 35-156 2.10e-11

Hypoxanthine phosphoribosyltransferase [Coenzyme transport and metabolism]; Hypoxanthine phosphoribosyltransferase is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 441837 [Multi-domain]  Cd Length: 153  Bit Score: 59.09  E-value: 2.10e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491954486  35 VLVGIKTRGIYLAHRIAKRLEQLEglkvpVGELDIRFYRDDVHKIDHehqPDVEGaQLPVNITGKHVILVDDVIFTGRTI 114
Cdd:COG2236   34 VIVAIARGGLVPARILADALGVPD-----LASIRVSSYTGTAKRLEE---PVVKG-PLDEDLAGKRVLIVDDVADTGRTL 104

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 491954486 115 RAALDALMDEGrPRKISLAVLVDRGHRElpIRPDFVGKNIPT 156
Cdd:COG2236  105 EAVRDLLKEAG-PAEVRTAVLYYKPSSK--FKPDYYAEETDA 143
PRK09162 PRK09162
hypoxanthine-guanine phosphoribosyltransferase; Provisional
 1-155 4.14e-11

hypoxanthine-guanine phosphoribosyltransferase; Provisional


Pssm-ID: 181675  Cd Length: 181  Bit Score: 58.72  E-value: 4.14e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491954486   1 MAQSKQVVDEVTMKRALTRISYEIIEQNKGLNDLVLVgIKTRGIYLAHRIAKRLEQleglkvPVgELD----IRfYRDDV 76
Cdd:PRK09162  10 LAEADCLVSAAEVEAAIDRMADEITADLADENPLVLC-VMGGGLVFTGQLLPRLDF------PL-EFDylhaTR-YRNET 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491954486  77 H--KIDHEHQPDVegaqlpvNITGKHVILVDDVIFTGRTIRAALDALMDEGrPRKISLAVLVDRGH-RELP-IRPDFVGK 152
Cdd:PRK09162  81 TggELVWKVKPRE-------SLKGRTVLVVDDILDEGHTLAAIRDRCLEMG-AAEVYSAVLVDKTHdRKAKpLKADFVGL 152


                 ...
gi 491954486 153 NIP 155
Cdd:PRK09162 153 EVP 155
COG1926 COG1926
Predicted phosphoribosyltransferase [General function prediction only];
93-134 1.87e-08

Predicted phosphoribosyltransferase [General function prediction only];


Pssm-ID: 441529  Cd Length: 209  Bit Score: 51.61  E-value: 1.87e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 491954486  93 PVNITGKHVILVDDVIFTGRTIRAALDALMDEGrPRKISLAV 134
Cdd:COG1926  116 PPDLKGRTVILVDDGIATGATMRAALRALRRQG-PARIVVAV 156
PRK02277 PRK02277
orotate phosphoribosyltransferase-like protein; Provisional
 18-147 5.81e-08

orotate phosphoribosyltransferase-like protein; Provisional


Pssm-ID: 235023 [Multi-domain]  Cd Length: 200  Bit Score: 50.25  E-value: 5.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491954486  18 TRISY------EIIEQNKGLNDLVlVGIKTRGIYLAHRIAKrleqleglkvpvgELDIRF--YRDdvHKIDHEHQPDVEG 89
Cdd:PRK02277  66 SRLRYiasamaDMLEKEDEEVDVV-VGIAKSGVPLATLVAD-------------ELGKDLaiYHP--KKWDHGEGEKKTG 129

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491954486  90 AqLPVN---ITGKHVILVDDVIFTGRTIRAALDALMDEG-RPRKIslAVLVD-RGHREL---PIRP 147
Cdd:PRK02277 130 S-FSRNfasVEGKRCVIVDDVITSGTTMKETIEYLKEHGgKPVAV--VVLIDkSGIDEIdgvPVYS 192
PRK06031 PRK06031
phosphoribosyltransferase; Provisional
 35-143 5.79e-07

phosphoribosyltransferase; Provisional


Pssm-ID: 235678  Cd Length: 233  Bit Score: 47.83  E-value: 5.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491954486  35 VLVGIKTRGIYLAHRIAKRLEQleGLKVPVGELDIRFYRDD----VHKI---DHEHQPDVEGAQLPVnITGKHVILVDDV 107
Cdd:PRK06031  87 VVAGLPTLGLTLAAAVARKLGH--TRYVPLGTSRKFWYRDElsvpLSSIttpDQGKRLYIDPRMLPL-LEGRRVALIDDV 163

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 491954486 108 IFTGRTIRAALDALMDEG-RPRKISLAVLVDRGHREL 143
Cdd:PRK06031 164 ISSGASIVAGLRLLAACGiEPAGIGAAMLQSERWRES 200
ComFC COG1040
DNA utilization protein ComFC/GntX, contains phosphoribosyltransferase domain [General ...
 93-135 7.62e-07

DNA utilization protein ComFC/GntX, contains phosphoribosyltransferase domain [General function prediction only];


Pssm-ID: 440662 [Multi-domain]  Cd Length: 196  Bit Score: 47.12  E-value: 7.62e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 491954486  93 PVNITGKHVILVDDVIFTGRTIRAALDALMDEGrPRKISLAVL 135
Cdd:COG1040  150 PARLAGKHVLLVDDVLTTGATLAEAARALKAAG-AARVDVLVL 191
PLN02238 PLN02238
hypoxanthine phosphoribosyltransferase
 85-142 8.33e-07

hypoxanthine phosphoribosyltransferase


Pssm-ID: 215132  Cd Length: 189  Bit Score: 46.95  E-value: 8.33e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 491954486  85 PDVEGAQLPVNITGKHVILVDDVIFTGRTIRAALDALMDEGrPRKISLAVLVDRGHRE 142
Cdd:PLN02238  84 AKVSGADLKIDVKGKHVLLVEDIVDTGNTLSALVAHLEAKG-AASVSVCALLDKRARR 140
upp PRK00129
uracil phosphoribosyltransferase; Reviewed
 72-136 3.10e-05

uracil phosphoribosyltransferase; Reviewed


Pssm-ID: 234653  Cd Length: 209  Bit Score: 42.77  E-value: 3.10e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491954486  72 YRDDVHkidheHQPDVEGAQLPVNITGKHVILVDDVIFTGRTIRAALDALMDEGrPRKISLAVLV 136
Cdd:PRK00129 103 YRDEET-----LEPVEYYVKLPEDIDERTVIVVDPMLATGGSAIAAIDLLKKRG-AKNIKVLCLV 161
UPRTase pfam14681
Uracil phosphoribosyltransferase; This family includes the enzyme uracil ...
 62-136 1.33e-04

Uracil phosphoribosyltransferase; This family includes the enzyme uracil phosphoribosyltransferase (EC:2.4.2.9). This enzyme catalyzes the first step of UMP biosynthesis.


Pssm-ID: 434124  Cd Length: 204  Bit Score: 40.94  E-value: 1.33e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491954486   62 VPVGELDIrfYRDDVHKIDHEHQpdvegAQLPVNITGKHVILVDDVIFTGRTIRAALDALMDEG-RPRKISLAVLV 136
Cdd:pfam14681  89 ARVGHIGI--QRDEETLQPVEYY-----NKLPKDISDRTVILLDPMLATGGSAIAAIQVLREHGvPEENIVVLSVI 157
PyrE COG0461
Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate ...
 35-139 2.45e-04

Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate phosphoribosyltransferase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440229  Cd Length: 201  Bit Score: 40.14  E-value: 2.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491954486  35 VLVGIKTRGIYLAHRIAKRLEqleglkvpvgeLDIRFYRDDVHkiDHEHQPDVEGAQLPvnitGKHVILVDDVIFTGRTI 114
Cdd:COG0461   66 AVAGPATGGIPLAAAVARALG-----------LPAIFVRKEAK--DHGTGGQIEGGLLP----GERVLVVEDVITTGGSV 128

                         90       100
                 ....*....|....*....|....*.
gi 491954486 115 RAALDALMDEG-RPRKIslAVLVDRG 139
Cdd:COG0461  129 LEAVEALREAGaEVVGV--AVIVDRE 152
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
95-125 4.06e-04

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 39.72  E-value: 4.06e-04
                         10        20        30
                 ....*....|....*....|....*....|.
gi 491954486  95 NITGKHVILVDDVIFTGRTIRAALDALMDEG 125
Cdd:PRK01259 205 DVEGRDCILVDDMIDTAGTLCKAAEALKERG 235
PRK07322 PRK07322
adenine phosphoribosyltransferase; Provisional
 35-124 9.01e-04

adenine phosphoribosyltransferase; Provisional


Pssm-ID: 180928  Cd Length: 178  Bit Score: 38.42  E-value: 9.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491954486  35 VLVGIKTRGIYLAHRIAKRLeqleGLKVPVGELDIRFYRDD-----VHKIDHEHQ-------PDVEGaqlpvnITGKHVI 102
Cdd:PRK07322  55 VLVTPETKGIPLAHALSRRL----GKPYVVARKSRKPYMQDpiiqeVVSITTGKPqllvldgADAEK------LKGKRVA 124

                         90       100
                 ....*....|....*....|..
gi 491954486 103 LVDDVIFTGRTIRaALDALMDE 124
Cdd:PRK07322 125 IVDDVVSTGGTLT-ALERLVER 145
PRTase_2 pfam15609
Phosphoribosyl transferase; This PRTase family, and C-terminal TRSP domain, are related to ...
 97-150 9.47e-04

Phosphoribosyl transferase; This PRTase family, and C-terminal TRSP domain, are related to OPRTases, and are predicted to use Orotate as substrate. These genes are found in the biosynthetic operon associated with the Ter stress-response operon and are predicted to be involved in the biosynthesis of a ribo-nucleoside involved in stress response.


Pssm-ID: 434809  Cd Length: 189  Bit Score: 38.31  E-value: 9.47e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491954486   97 TGKHVILVDDVIFTGRTIRAALDALMDEGRPRKISLAVLVD-RG----------HRELPIRPDFV 150
Cdd:pfam15609 119 GARPLVLVDDEISTGNTALNLIRALHAKLPRKRYVVVSLVDwRSpedraafaalAAELGIPIDVV 183
PTZ00149 PTZ00149
hypoxanthine phosphoribosyltransferase; Provisional
 96-155 1.94e-03

hypoxanthine phosphoribosyltransferase; Provisional


Pssm-ID: 240293  Cd Length: 241  Bit Score: 37.82  E-value: 1.94e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491954486  96 ITGKHVILVDDVIFTGRTIRAALDALMDEGrPRKISLAVLVD-RGHRELPIRPDFVGKNIP 155
Cdd:PTZ00149 148 LKDKHVLIVEDIIDTGNTLVKFCEYLKKFE-PKTIRIATLFEkRTPLSNGFKGDFVGFSIP 207
PRK03092 PRK03092
ribose-phosphate diphosphokinase;
95-125 4.47e-03

ribose-phosphate diphosphokinase;


Pssm-ID: 179535 [Multi-domain]  Cd Length: 304  Bit Score: 36.85  E-value: 4.47e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 491954486  95 NITGKHVILVDDVIFTGRTIRAALDALMDEG 125
Cdd:PRK03092 198 DVEGRTCVLVDDMIDTGGTIAGAVRALKEAG 228
pyrE PRK00455
orotate phosphoribosyltransferase; Validated
 87-139 7.65e-03

orotate phosphoribosyltransferase; Validated


Pssm-ID: 234771  Cd Length: 202  Bit Score: 35.52  E-value: 7.65e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 491954486  87 VEGAQLPvnitGKHVILVDDVIFTGRTIRAALDALMDEGrPRKISLAVLVDRG 139
Cdd:PRK00455 106 IEGRRLF----GKRVLVVEDVITTGGSVLEAVEAIRAAG-AEVVGVAVIVDRQ 153
PLN02369 PLN02369
ribose-phosphate pyrophosphokinase
 32-125 8.89e-03

ribose-phosphate pyrophosphokinase


Pssm-ID: 215209 [Multi-domain]  Cd Length: 302  Bit Score: 35.83  E-value: 8.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491954486  32 NDLVLVGIKTRGIYLAHRIAKRLEQLeglkvPVGELDIRFYRDDVhkidhehqpdVEGAQLPVNITGKHVILVDDVIFTG 111
Cdd:PLN02369 151 PDLVVVSPDVGGVARARAFAKKLSDA-----PLAIVDKRRQGHNV----------AEVMNLIGDVKGKVAIMVDDMIDTA 215

                         90
                 ....*....|....
gi 491954486 112 RTIRAALDALMDEG 125
Cdd:PLN02369 216 GTITKGAALLHQEG 229
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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