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Conserved domains on  [gi|491866440|ref|WP_005641945|]
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MULTISPECIES: ferritin-like domain-containing protein [Bacteroidales]

Protein Classification

ferritin family protein( domain architecture ID 38)

ferritin family protein similar to rubrerythrin, a non-heme di-iron that is involved in oxidative stress defense as a peroxide scavenger in a wide range of organisms

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FtnA super family cl42346
Ferritin [Inorganic ion transport and metabolism];
1-101 3.76e-20

Ferritin [Inorganic ion transport and metabolism];


The actual alignment was detected with superfamily member COG1528:

Pssm-ID: 441137  Cd Length: 158  Bit Score: 80.94  E-value: 3.76e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491866440   1 MDKRIENAMNELINTEIWSTGLYLSLQVYFEDERLPILSSWLNSQAQDNMNKVYQMMNRICHDGGCVVINEMKRDTHEWT 80
Cdd:COG1528    2 LSEKMEKALNEQINLEFYSSYLYLAMAAWCDEKGLPGFANFFRVQAQEERTHAMKFFDYLNDRGGRVELPAIDAPPNEFE 81

                         90       100
                 ....*....|....*....|.
gi 491866440  81 TPLNALNELLEHEQYISRQVN 101
Cdd:COG1528   82 SLLEVFEAALEHEQKVTKSIN 102
 
Name Accession Description Interval E-value
FtnA COG1528
Ferritin [Inorganic ion transport and metabolism];
1-101 3.76e-20

Ferritin [Inorganic ion transport and metabolism];


Pssm-ID: 441137  Cd Length: 158  Bit Score: 80.94  E-value: 3.76e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491866440   1 MDKRIENAMNELINTEIWSTGLYLSLQVYFEDERLPILSSWLNSQAQDNMNKVYQMMNRICHDGGCVVINEMKRDTHEWT 80
Cdd:COG1528    2 LSEKMEKALNEQINLEFYSSYLYLAMAAWCDEKGLPGFANFFRVQAQEERTHAMKFFDYLNDRGGRVELPAIDAPPNEFE 81

                         90       100
                 ....*....|....*....|.
gi 491866440  81 TPLNALNELLEHEQYISRQVN 101
Cdd:COG1528   82 SLLEVFEAALEHEQKVTKSIN 102
Nonheme_Ferritin cd01055
nonheme-containing ferritins; Nonheme Ferritin domain, found in archaea and bacteria, is a ...
 2-101 6.20e-17

nonheme-containing ferritins; Nonheme Ferritin domain, found in archaea and bacteria, is a member of a broad superfamily of ferritin-like diiron-carboxylate proteins. The ferritin protein shell is composed of 24 protein subunits arranged in 432 symmetry. Each protein subunit, a four-helix bundle with a fifth short terminal helix, contains a dinuclear ferroxidase center (H type). Unique to this group of proteins is a third metal site in the ferroxidase center. Iron storage involves the uptake of iron (II) at the protein shell, its oxidation by molecular oxygen at the ferroxidase centers, and the movement of iron (III) into the cavity for deposition as ferrihydrite.


Pssm-ID: 153113  Cd Length: 156  Bit Score: 72.52  E-value: 6.20e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491866440   2 DKRIENAMNELINTEIWSTGLYLSLQVYFEDERLPILSSWLNSQAQDNMNKVYQMMNRICHDGGCVVINEMKRDTHEWTT 81
Cdd:cd01055    1 SEKLEKALNEQINLELYSSYLYLAMAAWFDSKGLDGFANFFRVQAQEEREHAMKFFDYLNDRGGRVELPAIEAPPSEFES 80

                         90       100
                 ....*....|....*....|
gi 491866440  82 PLNALNELLEHEQYISRQVN 101
Cdd:cd01055   81 LLEVFEAALEHEQKVTESIN 100
Ferritin pfam00210
Ferritin-like domain; This family contains ferritins and other ferritin-like proteins such as ...
 6-101 1.24e-07

Ferritin-like domain; This family contains ferritins and other ferritin-like proteins such as members of the DPS family and bacterioferritins.


Pssm-ID: 459712  Cd Length: 141  Bit Score: 47.67  E-value: 1.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491866440    6 ENAMNELINTEIWSTGLYLSLQVYFEDERLPILSSWLNSQAQDNMNKVYQMMNRI-----CHDGGCVVINEMKRDThEWT 80
Cdd:pfam00210   1 IAALNEQLADELTASYQYLQMHWYVKGPGFEGLHEFFDEQAEEEREHADKLAERIldlggTPNGTRVELLAIEAPP-SFG 79

                          90       100
                  ....*....|....*....|.
gi 491866440   81 TPLNALNELLEHEQYISRQVN 101
Cdd:pfam00210  80 SVLEVLEAALEHEKKVTKSLR 100
PRK10304 PRK10304
non-heme ferritin;
9-111 2.58e-05

non-heme ferritin;


Pssm-ID: 182367  Cd Length: 165  Bit Score: 41.95  E-value: 2.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491866440   9 MNELINTEIWSTGLYLSLQVYFEDERLPILSSWLNSQAQDNMNKVYQMMNRICHDGGCVVINEMKRDTHEWTTPLNALNE 88
Cdd:PRK10304  10 LNEQMNLELYSSLLYQQMSAWCSYHTFEGAAAFLRRHAQEEMTHMQRLFDYLTDTGNLPRINTVESPFAEYSSLDELFQE 89

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 491866440  89 LLEHEQYISRQVN-------------TFLILCWNVS 111
Cdd:PRK10304  90 TYKHEQLITQKINelahaamtnqdypTFNFLQWYVS 125
 
Name Accession Description Interval E-value
FtnA COG1528
Ferritin [Inorganic ion transport and metabolism];
1-101 3.76e-20

Ferritin [Inorganic ion transport and metabolism];


Pssm-ID: 441137  Cd Length: 158  Bit Score: 80.94  E-value: 3.76e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491866440   1 MDKRIENAMNELINTEIWSTGLYLSLQVYFEDERLPILSSWLNSQAQDNMNKVYQMMNRICHDGGCVVINEMKRDTHEWT 80
Cdd:COG1528    2 LSEKMEKALNEQINLEFYSSYLYLAMAAWCDEKGLPGFANFFRVQAQEERTHAMKFFDYLNDRGGRVELPAIDAPPNEFE 81

                         90       100
                 ....*....|....*....|.
gi 491866440  81 TPLNALNELLEHEQYISRQVN 101
Cdd:COG1528   82 SLLEVFEAALEHEQKVTKSIN 102
Nonheme_Ferritin cd01055
nonheme-containing ferritins; Nonheme Ferritin domain, found in archaea and bacteria, is a ...
 2-101 6.20e-17

nonheme-containing ferritins; Nonheme Ferritin domain, found in archaea and bacteria, is a member of a broad superfamily of ferritin-like diiron-carboxylate proteins. The ferritin protein shell is composed of 24 protein subunits arranged in 432 symmetry. Each protein subunit, a four-helix bundle with a fifth short terminal helix, contains a dinuclear ferroxidase center (H type). Unique to this group of proteins is a third metal site in the ferroxidase center. Iron storage involves the uptake of iron (II) at the protein shell, its oxidation by molecular oxygen at the ferroxidase centers, and the movement of iron (III) into the cavity for deposition as ferrihydrite.


Pssm-ID: 153113  Cd Length: 156  Bit Score: 72.52  E-value: 6.20e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491866440   2 DKRIENAMNELINTEIWSTGLYLSLQVYFEDERLPILSSWLNSQAQDNMNKVYQMMNRICHDGGCVVINEMKRDTHEWTT 81
Cdd:cd01055    1 SEKLEKALNEQINLELYSSYLYLAMAAWFDSKGLDGFANFFRVQAQEEREHAMKFFDYLNDRGGRVELPAIEAPPSEFES 80

                         90       100
                 ....*....|....*....|
gi 491866440  82 PLNALNELLEHEQYISRQVN 101
Cdd:cd01055   81 LLEVFEAALEHEQKVTESIN 100
Ferritin cd00904
Ferritin iron storage proteins; Ferritins are the primary iron storage proteins of most living ...
 4-100 1.44e-09

Ferritin iron storage proteins; Ferritins are the primary iron storage proteins of most living organisms and members of a broad superfamily of ferritin-like diiron-carboxylate proteins. The iron-free (apoferritin) ferritin molecule is a protein shell composed of 24 protein chains arranged in 432 symmetry. Iron storage involves the uptake of iron (II) at the protein shell, its oxidation by molecular oxygen at the dinuclear ferroxidase centers, and the movement of iron (III) into the cavity for deposition as ferrihydrite; the protein shell can hold up to 4500 iron atoms. In vertebrates, two types of chains (subunits) have been characterized, H or M (fast) and L (slow), which differ in rates of iron uptake and mineralization. Bacterial non-heme ferritins are composed only of H chains. Fe(II) oxidation in the H/M subunits take place initially at the ferroxidase center, a carboxylate-bridged diiron center, located within the subunit four-helix bundle. In a complementary role, negatively charged residues on the protein shell inner surface of the L subunits promote ferrihydrite nucleation. Most plant ferritins combine both oxidase and nucleation functions in one chain: they have four interior glutamate residues as well as seven ferroxidase center residues.


Pssm-ID: 153098  Cd Length: 160  Bit Score: 53.42  E-value: 1.44e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491866440   4 RIENAMNELINTEIWSTGLYLSLQVYF--EDERLPILSSWLNSQAQDNMNKVYQMMNRICHDGGCVVINEMKR-DTHEWT 80
Cdd:cd00904    3 KVEAAVNRQLNLELYASYTYLSMATYFdrDDVALKGVAHFFKEQAQEEREHAEKFYKYQNERGGRVELQDIEKpPSDEWG 82

                         90       100
                 ....*....|....*....|
gi 491866440  81 TPLNALNELLEHEQYISRQV 100
Cdd:cd00904   83 GTLDAMEAALKLEKFVNQAL 102
Ferritin pfam00210
Ferritin-like domain; This family contains ferritins and other ferritin-like proteins such as ...
 6-101 1.24e-07

Ferritin-like domain; This family contains ferritins and other ferritin-like proteins such as members of the DPS family and bacterioferritins.


Pssm-ID: 459712  Cd Length: 141  Bit Score: 47.67  E-value: 1.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491866440    6 ENAMNELINTEIWSTGLYLSLQVYFEDERLPILSSWLNSQAQDNMNKVYQMMNRI-----CHDGGCVVINEMKRDThEWT 80
Cdd:pfam00210   1 IAALNEQLADELTASYQYLQMHWYVKGPGFEGLHEFFDEQAEEEREHADKLAERIldlggTPNGTRVELLAIEAPP-SFG 79

                          90       100
                  ....*....|....*....|.
gi 491866440   81 TPLNALNELLEHEQYISRQVN 101
Cdd:pfam00210  80 SVLEVLEAALEHEKKVTKSLR 100
PRK10304 PRK10304
non-heme ferritin;
9-111 2.58e-05

non-heme ferritin;


Pssm-ID: 182367  Cd Length: 165  Bit Score: 41.95  E-value: 2.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491866440   9 MNELINTEIWSTGLYLSLQVYFEDERLPILSSWLNSQAQDNMNKVYQMMNRICHDGGCVVINEMKRDTHEWTTPLNALNE 88
Cdd:PRK10304  10 LNEQMNLELYSSLLYQQMSAWCSYHTFEGAAAFLRRHAQEEMTHMQRLFDYLTDTGNLPRINTVESPFAEYSSLDELFQE 89

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 491866440  89 LLEHEQYISRQVN-------------TFLILCWNVS 111
Cdd:PRK10304  90 TYKHEQLITQKINelahaamtnqdypTFNFLQWYVS 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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