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Conserved domains on  [gi|491515193|ref|WP_005372826|]
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MULTISPECIES: tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE [Photobacterium]

Protein Classification

P-loop NTPase family protein( domain architecture ID 1562424)

P-loop NTPase (nucleoside triphosphate hydrolase) family protein contains two conserved sequence signatures, the Walker A motif (the P-loop proper) and Walker B motif which bind, respectively, the beta and gamma phosphate moieties of the bound nucleotide (typically ATP or GTP), and a Mg(2+) cation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 1-151 1.23e-84

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member PRK10646:

Pssm-ID: 476819  Cd Length: 153  Bit Score: 245.06  E-value: 1.23e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491515193   1 MQTFETFLADEQATVDLGLKLAKACTQQTTIYLHGDLGAGKTTFSRGFIRALGHQGNVKSPTYTLVEPYDLAPWQVYHFD 80
Cdd:PRK10646   1 MMNRVIPLPDEQATLDLGARVAKACDGATVIYLYGDLGAGKTTFSRGFLQALGHQGNVKSPTYTLVEPYTLDNLMVYHFD 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491515193  81 LYRLADPEELEFMGIRDYFTQDAICLVEWPEKGDGLLPQPDLELEMCYHGEQRKVLIRANTEYGATLINHL 151
Cdd:PRK10646  81 LYRLADPEELEFMGIRDYFANDAICLVEWPQQGAGVLPDPDVEIHLDYQAQGREARVSAVSSAGELLLARL 151
 
Name Accession Description Interval E-value
PRK10646 PRK10646
tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE;
1-151 1.23e-84

tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE;


Pssm-ID: 182615  Cd Length: 153  Bit Score: 245.06  E-value: 1.23e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491515193   1 MQTFETFLADEQATVDLGLKLAKACTQQTTIYLHGDLGAGKTTFSRGFIRALGHQGNVKSPTYTLVEPYDLAPWQVYHFD 80
Cdd:PRK10646   1 MMNRVIPLPDEQATLDLGARVAKACDGATVIYLYGDLGAGKTTFSRGFLQALGHQGNVKSPTYTLVEPYTLDNLMVYHFD 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491515193  81 LYRLADPEELEFMGIRDYFTQDAICLVEWPEKGDGLLPQPDLELEMCYHGEQRKVLIRANTEYGATLINHL 151
Cdd:PRK10646  81 LYRLADPEELEFMGIRDYFANDAICLVEWPQQGAGVLPDPDVEIHLDYQAQGREARVSAVSSAGELLLARL 151
TsaE COG0802
tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE [Translation, ribosomal ...
 8-152 6.73e-75

tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE [Translation, ribosomal structure and biogenesis]; tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440565  Cd Length: 146  Bit Score: 219.96  E-value: 6.73e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491515193   8 LADEQATVDLGLKLAKACTQQTTIYLHGDLGAGKTTFSRGFIRALGHQGNVKSPTYTLVEPYDLAPWQVYHFDLYRLADP 87
Cdd:COG0802    1 LPSEEETEALGARLAALLKPGDVILLEGDLGAGKTTFVRGLARGLGVTGEVTSPTFTLVNEYELGRLPLYHFDLYRLEDP 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491515193  88 EELEFMGIRDYFTQDAICLVEWPEKGDGLLPQPDLELEMCYHGE-QRKVLIRANTEYGATLINHLE 152
Cdd:COG0802   81 EELEDLGLEEYLDGDGVCLIEWPERIEGLLPEDDLEITIEYLGEdGRRITLTAHGPRGERLLEALA 146
TsaE pfam02367
Threonylcarbamoyl adenosine biosynthesis protein TsaE; This family of proteins is involved in ...
 8-133 1.30e-66

Threonylcarbamoyl adenosine biosynthesis protein TsaE; This family of proteins is involved in the synthesis of threonylcarbamoyl adenosine (t(6)A).


Pssm-ID: 460540  Cd Length: 127  Bit Score: 198.42  E-value: 1.30e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491515193    8 LADEQATVDLGLKLAKACTQQTTIYLHGDLGAGKTTFSRGFIRALGHQGNVKSPTYTLVEPYDLAPWQVYHFDLYRLADP 87
Cdd:pfam02367   1 LNSEEETEALGKRLAALLKPGDVILLSGDLGAGKTTFTRGLARGLGVTGPVTSPTFTLVNEYEGGGLPLYHFDLYRLEDP 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 491515193   88 EELEFMGIRDYFTQDAICLVEWPEKGDGLLPQPDLELEMCYHGEQR 133
Cdd:pfam02367  81 EELEDLGLEDYFDGDGVCLIEWPERIEELLPEDDLDIEIEREGEEG 126
T6A_YjeE TIGR00150
tRNA threonylcarbamoyl adenosine modification protein YjeE; This protein family belongs to a ...
 7-135 6.95e-62

tRNA threonylcarbamoyl adenosine modification protein YjeE; This protein family belongs to a four-gene system responsible for the threonylcarbamoyl adenosine (t6A) tRNA modification. Members of this family have a conserved nucleotide-binding motif GXXGXGKT and a nucleotide-binding fold. Member protein YjeE of Haemophilus influenzae (HI0065) was shown to have (weak) ATPase activity. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129254  Cd Length: 133  Bit Score: 186.49  E-value: 6.95e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491515193    7 FLADEQATVDLGLKLAKACTQQTTIYLHGDLGAGKTTFSRGFIRALGHQGNVKSPTYTLVEPYDLAPWQVYHFDLYRLAD 86
Cdd:TIGR00150   1 ANPDEKAMDKFGKAFAKPLDFGTVVLLKGDLGAGKTTLVQGLLQGLGIQGNVTSPTFTLVNEYNEGNLMVYHFDLYRLAD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 491515193   87 PEELEFMGIRDYFTQDAICLVEWPEKGDGLLPQPDLELEMCYHGEQRKV 135
Cdd:TIGR00150  81 PEELELMGLEDYFEGDGICLVEWPEEGLEILPDYDLQIKIDYVGDGREI 129
 
Name Accession Description Interval E-value
PRK10646 PRK10646
tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE;
1-151 1.23e-84

tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE;


Pssm-ID: 182615  Cd Length: 153  Bit Score: 245.06  E-value: 1.23e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491515193   1 MQTFETFLADEQATVDLGLKLAKACTQQTTIYLHGDLGAGKTTFSRGFIRALGHQGNVKSPTYTLVEPYDLAPWQVYHFD 80
Cdd:PRK10646   1 MMNRVIPLPDEQATLDLGARVAKACDGATVIYLYGDLGAGKTTFSRGFLQALGHQGNVKSPTYTLVEPYTLDNLMVYHFD 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491515193  81 LYRLADPEELEFMGIRDYFTQDAICLVEWPEKGDGLLPQPDLELEMCYHGEQRKVLIRANTEYGATLINHL 151
Cdd:PRK10646  81 LYRLADPEELEFMGIRDYFANDAICLVEWPQQGAGVLPDPDVEIHLDYQAQGREARVSAVSSAGELLLARL 151
TsaE COG0802
tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE [Translation, ribosomal ...
 8-152 6.73e-75

tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE [Translation, ribosomal structure and biogenesis]; tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440565  Cd Length: 146  Bit Score: 219.96  E-value: 6.73e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491515193   8 LADEQATVDLGLKLAKACTQQTTIYLHGDLGAGKTTFSRGFIRALGHQGNVKSPTYTLVEPYDLAPWQVYHFDLYRLADP 87
Cdd:COG0802    1 LPSEEETEALGARLAALLKPGDVILLEGDLGAGKTTFVRGLARGLGVTGEVTSPTFTLVNEYELGRLPLYHFDLYRLEDP 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491515193  88 EELEFMGIRDYFTQDAICLVEWPEKGDGLLPQPDLELEMCYHGE-QRKVLIRANTEYGATLINHLE 152
Cdd:COG0802   81 EELEDLGLEEYLDGDGVCLIEWPERIEGLLPEDDLEITIEYLGEdGRRITLTAHGPRGERLLEALA 146
TsaE pfam02367
Threonylcarbamoyl adenosine biosynthesis protein TsaE; This family of proteins is involved in ...
 8-133 1.30e-66

Threonylcarbamoyl adenosine biosynthesis protein TsaE; This family of proteins is involved in the synthesis of threonylcarbamoyl adenosine (t(6)A).


Pssm-ID: 460540  Cd Length: 127  Bit Score: 198.42  E-value: 1.30e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491515193    8 LADEQATVDLGLKLAKACTQQTTIYLHGDLGAGKTTFSRGFIRALGHQGNVKSPTYTLVEPYDLAPWQVYHFDLYRLADP 87
Cdd:pfam02367   1 LNSEEETEALGKRLAALLKPGDVILLSGDLGAGKTTFTRGLARGLGVTGPVTSPTFTLVNEYEGGGLPLYHFDLYRLEDP 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 491515193   88 EELEFMGIRDYFTQDAICLVEWPEKGDGLLPQPDLELEMCYHGEQR 133
Cdd:pfam02367  81 EELEDLGLEDYFDGDGVCLIEWPERIEELLPEDDLDIEIEREGEEG 126
T6A_YjeE TIGR00150
tRNA threonylcarbamoyl adenosine modification protein YjeE; This protein family belongs to a ...
 7-135 6.95e-62

tRNA threonylcarbamoyl adenosine modification protein YjeE; This protein family belongs to a four-gene system responsible for the threonylcarbamoyl adenosine (t6A) tRNA modification. Members of this family have a conserved nucleotide-binding motif GXXGXGKT and a nucleotide-binding fold. Member protein YjeE of Haemophilus influenzae (HI0065) was shown to have (weak) ATPase activity. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129254  Cd Length: 133  Bit Score: 186.49  E-value: 6.95e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491515193    7 FLADEQATVDLGLKLAKACTQQTTIYLHGDLGAGKTTFSRGFIRALGHQGNVKSPTYTLVEPYDLAPWQVYHFDLYRLAD 86
Cdd:TIGR00150   1 ANPDEKAMDKFGKAFAKPLDFGTVVLLKGDLGAGKTTLVQGLLQGLGIQGNVTSPTFTLVNEYNEGNLMVYHFDLYRLAD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 491515193   87 PEELEFMGIRDYFTQDAICLVEWPEKGDGLLPQPDLELEMCYHGEQRKV 135
Cdd:TIGR00150  81 PEELELMGLEDYFEGDGICLVEWPEEGLEILPDYDLQIKIDYVGDGREI 129
RNA_helicase pfam00910
RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding ...
 31-95 4.31e-03

RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding during viral RNA replication. Members of this family are found in a variety of single stranded RNA viruses.


Pssm-ID: 459992  Cd Length: 102  Bit Score: 34.89  E-value: 4.31e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491515193   31 IYLHGDLGAGKTTFSRGFIRAL-GHQGNVKSPTYTLvePYDLAPWQVYH-------FDLYRLAD-PEELEFMGI 95
Cdd:pfam00910   1 IWLYGPPGCGKSTLAKYLARALlKKLGLPKDSVYSR--NPDDDFWDGYTgqpvviiDDFGQNPDgPDEAELIRL 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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