|
Name |
Accession |
Description |
Interval |
E-value |
| NadD |
COG1057 |
Nicotinate-nucleotide adenylyltransferase NadD [Coenzyme transport and metabolism]; ... |
5-211 |
3.39e-82 |
|
Nicotinate-nucleotide adenylyltransferase NadD [Coenzyme transport and metabolism]; Nicotinate-nucleotide adenylyltransferase NadD is part of the Pathway/BioSystem: NAD biosynthesis
Pssm-ID: 440677 [Multi-domain] Cd Length: 197 Bit Score: 243.10 E-value: 3.39e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490555 5 PLGLLGGTFDPIHLGHLKPALAARDALRLGELRLLPNRVPPHRA-SPFCTPEQRLAMVYLA-ANEFGLGVDERELRRDRP 82
Cdd:COG1057 3 RIGIFGGTFDPIHIGHLALAEEAAEQLGLDEVIFVPAGQPPHKKhKPLASAEHRLAMLRLAiADNPRFEVSDIELERPGP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490555 83 SWTIETLEELRHELPDTPLCFLMGMDSLLSLPSWHRWDELLSLAHLVVSVRPGWDAAEatapvqalLARHGTLrvddlhq 162
Cdd:COG1057 83 SYTIDTLRELREEYPDAELYFIIGADALLQLPKWKRWEELLELAHLVVVPRPGYELDE--------LEELEAL------- 147
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 491490555 163 HRAGHIWLAHNEPQPLSSTEIRARLAAGNDPGELLPESVANYIRNNRLY 211
Cdd:COG1057 148 KPGGRIILLDVPLLDISSTEIRERLAEGKSIRYLVPDAVEDYIREHGLY 196
|
|
| NMNAT |
cd02165 |
Nicotinamide/nicotinate mononucleotide adenylyltransferase; Nicotinamide/nicotinate ... |
6-211 |
3.34e-75 |
|
Nicotinamide/nicotinate mononucleotide adenylyltransferase; Nicotinamide/nicotinate mononucleotide (NMN/ NaMN)adenylyltransferase (NMNAT). NMNAT represents the primary bacterial and eukaryotic adenylyltransferases for nicotinamide-nucleotide and for the deamido form, nicotinate nucleotide. It is an indispensable enzyme in the biosynthesis of NAD(+) and NADP(+). Nicotinamide-nucleotide adenylyltransferase synthesizes NAD via the salvage pathway, while nicotinate-nucleotide adenylyltransferase synthesizes the immediate precursor of NAD via the de novo pathway. Human NMNAT displays unique dual substrate specificity toward both NMN and NaMN, and can participate in both de novo and salvage pathways of NAD synthesis.
Pssm-ID: 185680 [Multi-domain] Cd Length: 192 Bit Score: 225.20 E-value: 3.34e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490555 6 LGLLGGTFDPIHLGHLKPALAARDALRLGELRLLPNRVPPHRASPFCTPEQRLAMVYLAANEF-GLGVDERELRRDRPSW 84
Cdd:cd02165 1 IALFGGSFDPPHLGHLAIAEEALEELGLDRVLLLPSANPPHKPPKPASFEHRLEMLKLAIEDNpKFEVSDIEIKRDGPSY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490555 85 TIETLEELRHELPDTPLCFLMGMDSLLSLPSWHRWDELLSLAHLVVSVRPGWDAAEATAPVQALlarhgtlrvddlhqhR 164
Cdd:cd02165 81 TIDTLEELRERYPNAELYFIIGSDNLIRLPKWYDWEELLSLVHLVVAPRPGYPIEDASLEKLLL---------------P 145
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 491490555 165 AGHIWLAHNEPQPLSSTEIRARLAAGNDPGELLPESVANYIRNNRLY 211
Cdd:cd02165 146 GGRIILLDNPLLNISSTEIRERLKNGKSIRYLLPPAVADYIKEHGLY 192
|
|
| nadD |
PRK00071 |
nicotinate-nucleotide adenylyltransferase; |
7-211 |
4.78e-71 |
|
nicotinate-nucleotide adenylyltransferase;
Pssm-ID: 234611 [Multi-domain] Cd Length: 203 Bit Score: 215.08 E-value: 4.78e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490555 7 GLLGGTFDPIHLGHLKPALAARDALRLGELRLLPNRVPPHRA-SPFCTPEQRLAMVYLAANEF-GLGVDERELRRDRPSW 84
Cdd:PRK00071 7 GLFGGTFDPPHYGHLAIAEEAAERLGLDEVWFLPNPGPPHKPqKPLAPLEHRLAMLELAIADNpRFSVSDIELERPGPSY 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490555 85 TIETLEELRHELPDTPLCFLMGMDSLLSLPSWHRWDELLSLAHLVVSVRPGWDAAEATAPVQALLARHgtlrvddlhqhr 164
Cdd:PRK00071 87 TIDTLRELRARYPDVELVFIIGADALAQLPRWKRWEEILDLVHFVVVPRPGYPLEALALPALQQLLEA------------ 154
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 491490555 165 AGHIWLAHNEPQPLSSTEIRARLAAGNDPGELLPESVANYIRNNRLY 211
Cdd:PRK00071 155 AGAITLLDVPLLAISSTAIRERIKEGRPIRYLLPEAVLDYIEKHGLY 201
|
|
| TIGR00482 |
TIGR00482 |
nicotinate (nicotinamide) nucleotide adenylyltransferase; This model represents the ... |
8-211 |
1.24e-59 |
|
nicotinate (nicotinamide) nucleotide adenylyltransferase; This model represents the predominant bacterial/eukaryotic adenylyltransferase for nicotinamide-nucleotide, its deamido form nicotinate nucleotide, or both. The first activity, nicotinamide-nucleotide adenylyltransferase (EC 2.7.7.1), synthesizes NAD by the salvage pathway, while the second, nicotinate-nucleotide adenylyltransferase (EC 2.7.7.18) synthesizes the immediate precursor of NAD by the de novo pathway. In E. coli, NadD activity is biased toward the de novo pathway while salvage activity is channeled through the multifunctional NadR protein, but this division of labor may be exceptional. The given name of this model, nicotinate (nicotinamide) nucleotide adenylyltransferase, reflects the lack of absolute specificity with respect to substrate amidation state in most species. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Pssm-ID: 273101 [Multi-domain] Cd Length: 193 Bit Score: 185.60 E-value: 1.24e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490555 8 LLGGTFDPIHLGHLKPALAARDALRLGELRLLPNRVPPHR----ASPFctpEQRLAMVYLA-ANEFGLGVDERELRRDRP 82
Cdd:TIGR00482 1 LFGGSFDPIHYGHLLLAEEALDHLDLDKVIFVPTANPPHKktyeAASS---HHRLAMLKLAiEDNPKFEVDDFEIKRGGP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490555 83 SWTIETLEELRHELPDTPLCFLMGMDSLLSLPSWHRWDELLSLAHLVVSVRPGWDAAEATAPVQALLARHgtlrvddlhq 162
Cdd:TIGR00482 78 SYTIDTLKHLKKKYPDVELYFIIGADALRSFPLWKDWQELLELVHLVIVPRPGYTLDKALLEKAILRMHH---------- 147
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 491490555 163 hraGHIWLAHNEPQPLSSTEIRARLAAGNDPGELLPESVANYIRNNRLY 211
Cdd:TIGR00482 148 ---GNLTLLHNPRVPISSTEIRQRIRQGKSIEYLLPDPVIKYIKQHGLY 193
|
|
| CTP_transf_like |
pfam01467 |
Cytidylyltransferase-like; This family includes: Cholinephosphate cytidylyltransferase; ... |
8-186 |
1.79e-18 |
|
Cytidylyltransferase-like; This family includes: Cholinephosphate cytidylyltransferase; glycerol-3-phosphate cytidylyltransferase. It also includes putative adenylyltransferases, and FAD synthases.
Pssm-ID: 396172 [Multi-domain] Cd Length: 134 Bit Score: 78.13 E-value: 1.79e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490555 8 LLGGTFDPIHLGHLKpalAARDALRLGELRL---LPNRVPPHR-ASPFCTPEQRLAMVYLAAnefglGVDERELRRDrps 83
Cdd:pfam01467 1 LFGGTFDPIHLGHLR---LLEQAKELFDEDLivgVPSDEPPHKlKRPLFSAEERLEMLELAK-----WVDEVIVVAP--- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490555 84 wtIETLEELRHEL-PDtplCFLMGMDSLLSLpsWHRWDELLSLAHLVVSVRPgwdaaeatapvqallarhgtlrvddlhq 162
Cdd:pfam01467 70 --WELTRELLKELnPD---VLVIGADSLLDF--WYELDEILGNVKLVVVVRP---------------------------- 114
|
170 180
....*....|....*....|....
gi 491490555 163 hragHIWLAHNEPQPLSSTEIRAR 186
Cdd:pfam01467 115 ----VFFIPLKPTNGISSTDIRER 134
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| NadD |
COG1057 |
Nicotinate-nucleotide adenylyltransferase NadD [Coenzyme transport and metabolism]; ... |
5-211 |
3.39e-82 |
|
Nicotinate-nucleotide adenylyltransferase NadD [Coenzyme transport and metabolism]; Nicotinate-nucleotide adenylyltransferase NadD is part of the Pathway/BioSystem: NAD biosynthesis
Pssm-ID: 440677 [Multi-domain] Cd Length: 197 Bit Score: 243.10 E-value: 3.39e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490555 5 PLGLLGGTFDPIHLGHLKPALAARDALRLGELRLLPNRVPPHRA-SPFCTPEQRLAMVYLA-ANEFGLGVDERELRRDRP 82
Cdd:COG1057 3 RIGIFGGTFDPIHIGHLALAEEAAEQLGLDEVIFVPAGQPPHKKhKPLASAEHRLAMLRLAiADNPRFEVSDIELERPGP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490555 83 SWTIETLEELRHELPDTPLCFLMGMDSLLSLPSWHRWDELLSLAHLVVSVRPGWDAAEatapvqalLARHGTLrvddlhq 162
Cdd:COG1057 83 SYTIDTLRELREEYPDAELYFIIGADALLQLPKWKRWEELLELAHLVVVPRPGYELDE--------LEELEAL------- 147
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 491490555 163 HRAGHIWLAHNEPQPLSSTEIRARLAAGNDPGELLPESVANYIRNNRLY 211
Cdd:COG1057 148 KPGGRIILLDVPLLDISSTEIRERLAEGKSIRYLVPDAVEDYIREHGLY 196
|
|
| NMNAT |
cd02165 |
Nicotinamide/nicotinate mononucleotide adenylyltransferase; Nicotinamide/nicotinate ... |
6-211 |
3.34e-75 |
|
Nicotinamide/nicotinate mononucleotide adenylyltransferase; Nicotinamide/nicotinate mononucleotide (NMN/ NaMN)adenylyltransferase (NMNAT). NMNAT represents the primary bacterial and eukaryotic adenylyltransferases for nicotinamide-nucleotide and for the deamido form, nicotinate nucleotide. It is an indispensable enzyme in the biosynthesis of NAD(+) and NADP(+). Nicotinamide-nucleotide adenylyltransferase synthesizes NAD via the salvage pathway, while nicotinate-nucleotide adenylyltransferase synthesizes the immediate precursor of NAD via the de novo pathway. Human NMNAT displays unique dual substrate specificity toward both NMN and NaMN, and can participate in both de novo and salvage pathways of NAD synthesis.
Pssm-ID: 185680 [Multi-domain] Cd Length: 192 Bit Score: 225.20 E-value: 3.34e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490555 6 LGLLGGTFDPIHLGHLKPALAARDALRLGELRLLPNRVPPHRASPFCTPEQRLAMVYLAANEF-GLGVDERELRRDRPSW 84
Cdd:cd02165 1 IALFGGSFDPPHLGHLAIAEEALEELGLDRVLLLPSANPPHKPPKPASFEHRLEMLKLAIEDNpKFEVSDIEIKRDGPSY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490555 85 TIETLEELRHELPDTPLCFLMGMDSLLSLPSWHRWDELLSLAHLVVSVRPGWDAAEATAPVQALlarhgtlrvddlhqhR 164
Cdd:cd02165 81 TIDTLEELRERYPNAELYFIIGSDNLIRLPKWYDWEELLSLVHLVVAPRPGYPIEDASLEKLLL---------------P 145
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 491490555 165 AGHIWLAHNEPQPLSSTEIRARLAAGNDPGELLPESVANYIRNNRLY 211
Cdd:cd02165 146 GGRIILLDNPLLNISSTEIRERLKNGKSIRYLLPPAVADYIKEHGLY 192
|
|
| nadD |
PRK00071 |
nicotinate-nucleotide adenylyltransferase; |
7-211 |
4.78e-71 |
|
nicotinate-nucleotide adenylyltransferase;
Pssm-ID: 234611 [Multi-domain] Cd Length: 203 Bit Score: 215.08 E-value: 4.78e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490555 7 GLLGGTFDPIHLGHLKPALAARDALRLGELRLLPNRVPPHRA-SPFCTPEQRLAMVYLAANEF-GLGVDERELRRDRPSW 84
Cdd:PRK00071 7 GLFGGTFDPPHYGHLAIAEEAAERLGLDEVWFLPNPGPPHKPqKPLAPLEHRLAMLELAIADNpRFSVSDIELERPGPSY 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490555 85 TIETLEELRHELPDTPLCFLMGMDSLLSLPSWHRWDELLSLAHLVVSVRPGWDAAEATAPVQALLARHgtlrvddlhqhr 164
Cdd:PRK00071 87 TIDTLRELRARYPDVELVFIIGADALAQLPRWKRWEEILDLVHFVVVPRPGYPLEALALPALQQLLEA------------ 154
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 491490555 165 AGHIWLAHNEPQPLSSTEIRARLAAGNDPGELLPESVANYIRNNRLY 211
Cdd:PRK00071 155 AGAITLLDVPLLAISSTAIRERIKEGRPIRYLLPEAVLDYIEKHGLY 201
|
|
| TIGR00482 |
TIGR00482 |
nicotinate (nicotinamide) nucleotide adenylyltransferase; This model represents the ... |
8-211 |
1.24e-59 |
|
nicotinate (nicotinamide) nucleotide adenylyltransferase; This model represents the predominant bacterial/eukaryotic adenylyltransferase for nicotinamide-nucleotide, its deamido form nicotinate nucleotide, or both. The first activity, nicotinamide-nucleotide adenylyltransferase (EC 2.7.7.1), synthesizes NAD by the salvage pathway, while the second, nicotinate-nucleotide adenylyltransferase (EC 2.7.7.18) synthesizes the immediate precursor of NAD by the de novo pathway. In E. coli, NadD activity is biased toward the de novo pathway while salvage activity is channeled through the multifunctional NadR protein, but this division of labor may be exceptional. The given name of this model, nicotinate (nicotinamide) nucleotide adenylyltransferase, reflects the lack of absolute specificity with respect to substrate amidation state in most species. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Pssm-ID: 273101 [Multi-domain] Cd Length: 193 Bit Score: 185.60 E-value: 1.24e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490555 8 LLGGTFDPIHLGHLKPALAARDALRLGELRLLPNRVPPHR----ASPFctpEQRLAMVYLA-ANEFGLGVDERELRRDRP 82
Cdd:TIGR00482 1 LFGGSFDPIHYGHLLLAEEALDHLDLDKVIFVPTANPPHKktyeAASS---HHRLAMLKLAiEDNPKFEVDDFEIKRGGP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490555 83 SWTIETLEELRHELPDTPLCFLMGMDSLLSLPSWHRWDELLSLAHLVVSVRPGWDAAEATAPVQALLARHgtlrvddlhq 162
Cdd:TIGR00482 78 SYTIDTLKHLKKKYPDVELYFIIGADALRSFPLWKDWQELLELVHLVIVPRPGYTLDKALLEKAILRMHH---------- 147
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 491490555 163 hraGHIWLAHNEPQPLSSTEIRARLAAGNDPGELLPESVANYIRNNRLY 211
Cdd:TIGR00482 148 ---GNLTLLHNPRVPISSTEIRQRIRQGKSIEYLLPDPVIKYIKQHGLY 193
|
|
| PRK06973 |
PRK06973 |
nicotinate-nucleotide adenylyltransferase; |
6-211 |
2.30e-44 |
|
nicotinate-nucleotide adenylyltransferase;
Pssm-ID: 180781 [Multi-domain] Cd Length: 243 Bit Score: 148.39 E-value: 2.30e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490555 6 LGLLGGTFDPIHLGHLkpALAAR--DALRLGELRLLPNRVPPHRASpfCTP-EQRLAMVYLAANEFGLG-----VDEREL 77
Cdd:PRK06973 24 IGILGGTFDPIHDGHL--ALARRfaDVLDLTELVLIPAGQPWQKAD--VSAaEHRLAMTRAAAASLVLPgvtvrVATDEI 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490555 78 RRDRPSWTIETLEELRHEL-PDTPLCFLMGMDSLLSLPSWHRWDELLSLAHLVVSVRPGWDAAEATAPVQALLA-RHGtl 155
Cdd:PRK06973 100 EHAGPTYTVDTLARWRERIgPDASLALLIGADQLVRLDTWRDWRRLFDYAHLCAATRPGFDLGAASPAVAAEIAaRQA-- 177
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491490555 156 RVDDLHQHRAGHIWLAHNEPQPLSSTEIRARLAAGND--------PGELLPESVANYIRNNRLY 211
Cdd:PRK06973 178 DADVLQATPAGHLLIDTTLAFDLSATDIRAHLRACIArraqvpdaSAEHVPAAVWAYILQHRLY 241
|
|
| nadD |
PRK07152 |
nicotinate-nucleotide adenylyltransferase; |
6-212 |
9.89e-29 |
|
nicotinate-nucleotide adenylyltransferase;
Pssm-ID: 235947 [Multi-domain] Cd Length: 342 Bit Score: 110.04 E-value: 9.89e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490555 6 LGLLGGTFDPIHLGHLKPALAARDALRLGELRLLPNRVpphraSPFCT------PEQRLAMVYLAANEFG-LGVDERELR 78
Cdd:PRK07152 3 IAIFGGSFDPIHKGHINIAKKAIKKLKLDKLFFVPTYI-----NPFKKkqkasnGEHRLNMLKLALKNLPkMEVSDFEIK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490555 79 RDRPSWTIETLEELRHELPDTPLCFLMGMDSLLSLPSWHRWDELLSLAHLVVSVRPGWDAAEatapvqallarhgtlrvd 158
Cdd:PRK07152 78 RQNVSYTIDTIKYFKKKYPNDEIYFIIGSDNLEKFKKWKNIEEILKKVQIVVFKRKKNINKK------------------ 139
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 491490555 159 DLHQHragHIWLAHNEPQPLSSTEIRarlaaGNDPGELLPESVANYIRNNRLYA 212
Cdd:PRK07152 140 NLKKY---NVLLLKNKNLNISSTKIR-----KGNLLGKLDPKVNDYINENFLYL 185
|
|
| CTP_transf_like |
pfam01467 |
Cytidylyltransferase-like; This family includes: Cholinephosphate cytidylyltransferase; ... |
8-186 |
1.79e-18 |
|
Cytidylyltransferase-like; This family includes: Cholinephosphate cytidylyltransferase; glycerol-3-phosphate cytidylyltransferase. It also includes putative adenylyltransferases, and FAD synthases.
Pssm-ID: 396172 [Multi-domain] Cd Length: 134 Bit Score: 78.13 E-value: 1.79e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490555 8 LLGGTFDPIHLGHLKpalAARDALRLGELRL---LPNRVPPHR-ASPFCTPEQRLAMVYLAAnefglGVDERELRRDrps 83
Cdd:pfam01467 1 LFGGTFDPIHLGHLR---LLEQAKELFDEDLivgVPSDEPPHKlKRPLFSAEERLEMLELAK-----WVDEVIVVAP--- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490555 84 wtIETLEELRHEL-PDtplCFLMGMDSLLSLpsWHRWDELLSLAHLVVSVRPgwdaaeatapvqallarhgtlrvddlhq 162
Cdd:pfam01467 70 --WELTRELLKELnPD---VLVIGADSLLDF--WYELDEILGNVKLVVVVRP---------------------------- 114
|
170 180
....*....|....*....|....
gi 491490555 163 hragHIWLAHNEPQPLSSTEIRAR 186
Cdd:pfam01467 115 ----VFFIPLKPTNGISSTDIRER 134
|
|
| cyt_tran_rel |
TIGR00125 |
cytidyltransferase-like domain; Protein families that contain at least one copy of this domain ... |
7-61 |
6.32e-08 |
|
cytidyltransferase-like domain; Protein families that contain at least one copy of this domain include citrate lyase ligase, pantoate-beta-alanine ligase, glycerol-3-phosphate cytidyltransferase, ADP-heptose synthase, phosphocholine cytidylyltransferase, lipopolysaccharide core biosynthesis protein KdtB, the bifunctional protein NadR, and a number whose function is unknown. Many of these proteins are known to use CTP or ATP and release pyrophosphate.
Pssm-ID: 272920 [Multi-domain] Cd Length: 66 Bit Score: 48.07 E-value: 6.32e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 491490555 7 GLLGGTFDPIHLGHLKpalAARDALRLGELRLLP----NRVPPHRASPFCTPEQRLAMV 61
Cdd:TIGR00125 2 VIFVGTFDPFHLGHLD---LLERAKELFDELIVGvgsdQFVNPLKGEPVFSLEERLEML 57
|
|
| NMNAT_Eukarya |
cd09286 |
Nicotinamide/nicotinate mononucleotide adenylyltransferase, Eukaryotic; Nicotinamide ... |
11-211 |
2.63e-07 |
|
Nicotinamide/nicotinate mononucleotide adenylyltransferase, Eukaryotic; Nicotinamide/nicotinate mononucleotide (NMN/ NaMN)adenylyltransferase (NMNAT). NMNAT represents the primary bacterial and eukaryotic adenylyltransferases for nicotinamide-nucleotide and for the deamido form, nicotinate nucleotide. It is an indispensable enzyme in the biosynthesis of NAD(+) and NADP(+). Nicotinamide-nucleotide adenylyltransferase synthesizes NAD via the salvage pathway, while nicotinate-nucleotide adenylyltransferase synthesizes the immediate precursor of NAD via the de novo pathway. Human NMNAT displays unique dual substrate specificity toward both NMN and NaMN, and can participate in both de novo and salvage pathways of NAD synthesis. This subfamily consists strictly of eukaryotic members and includes secondary structural elements not found in all NMNATs.
Pssm-ID: 185681 [Multi-domain] Cd Length: 225 Bit Score: 49.61 E-value: 2.63e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490555 11 GTFDPIHLGHLKPALAARDALR-LGELRLLPNRVPP----HRASPFCTPEQRLAMVYLAANEFG-LGVDERELRRdrPSW 84
Cdd:cd09286 7 GSFNPITNMHLRMFELARDHLHeTGRYEVVGGIISPvndaYGKKGLASAKHRVAMCRLAVQSSDwIRVDDWESLQ--PEW 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490555 85 TiETLEELRHE------------------LPDTPLC----FLMGMDSLLSLPSWHRWD-----ELLSLAHLVVSVRPGWD 137
Cdd:cd09286 85 M-RTAKVLRHHreeinnkyggiegaakrvLDGSRREvkimLLCGADLLESFGIPGLWKdadleEILGEFGLVVVERTGSD 163
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491490555 138 aaeatapVQALLARHGTLRvddLHQHRaghIWLAHNEPQP-LSSTEIRARLAAGNDPGELLPESVANYIRNNRLY 211
Cdd:cd09286 164 -------PENFIASSDILR---KYQDN---IHLVKDWIPNdISSTKVRRALRRGMSVKYLLPDPVIEYIEQHQLY 225
|
|
| PLN02945 |
PLN02945 |
nicotinamide-nucleotide adenylyltransferase/nicotinate-nucleotide adenylyltransferase |
11-211 |
4.42e-05 |
|
nicotinamide-nucleotide adenylyltransferase/nicotinate-nucleotide adenylyltransferase
Pssm-ID: 178531 [Multi-domain] Cd Length: 236 Bit Score: 43.14 E-value: 4.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490555 11 GTFDPIHLGHLKPALAARDALRLGELRLLPNRVPP-----HRASpFCTPEQRLAMVYLAANEFGL-GVDERELRRDRPSW 84
Cdd:PLN02945 29 GSFNPPTYMHLRMFELARDALMSEGYHVLGGYMSPvndayKKKG-LASAEHRIQMCQLACEDSDFiMVDPWEARQSTYQR 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490555 85 TIETLEELRHEL------PDTPL--CFLMGMDSLLSL--PSWHRWDELLSLA--HLVVSVRpgwdaaEATAPVQALLARH 152
Cdd:PLN02945 108 TLTVLARVETSLnnnglaSEESVrvMLLCGSDLLESFstPGVWIPDQVRTICrdYGVVCIR------REGQDVEKLVSQD 181
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 491490555 153 gtlrvDDLHQHRAGHIWLAHNEPQPLSSTEIRARLAAGNDPGELLPESVANYIRNNRLY 211
Cdd:PLN02945 182 -----EILNENRGNILVVDDLVPNSISSTRVRECISRGLSVKYLTPDGVIDYIKEHGLY 235
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|
| PRK01153 |
PRK01153 |
nicotinamide-nucleotide adenylyltransferase; Provisional |
178-206 |
7.33e-04 |
|
nicotinamide-nucleotide adenylyltransferase; Provisional
Pssm-ID: 179235 Cd Length: 174 Bit Score: 39.09 E-value: 7.33e-04
10 20
....*....|....*....|....*....
gi 491490555 178 LSSTEIRARLAAGNDPGELLPESVANYIR 206
Cdd:PRK01153 127 YSGTEIRRRMIEGDPWEELVPKSVAEVIK 155
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|
| PRK00777 |
PRK00777 |
pantetheine-phosphate adenylyltransferase; |
9-35 |
3.35e-03 |
|
pantetheine-phosphate adenylyltransferase;
Pssm-ID: 234834 Cd Length: 153 Bit Score: 36.73 E-value: 3.35e-03
10 20
....*....|....*....|....*..
gi 491490555 9 LGGTFDPIHLGHLKpaLAARdALRLGE 35
Cdd:PRK00777 6 VGGTFDPLHDGHRA--LLRK-AFELGK 29
|
|
| CAB4 |
COG1019 |
Phosphopantetheine adenylyltransferase [Coenzyme transport and metabolism]; Phosphopantetheine ... |
9-35 |
7.16e-03 |
|
Phosphopantetheine adenylyltransferase [Coenzyme transport and metabolism]; Phosphopantetheine adenylyltransferase is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis
Pssm-ID: 440642 Cd Length: 154 Bit Score: 35.94 E-value: 7.16e-03
10 20
....*....|....*....|....*..
gi 491490555 9 LGGTFDPIHLGHLkpALAARdALRLGE 35
Cdd:COG1019 6 VGGTFDPLHDGHR--ALLER-AFELGG 29
|
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