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Conserved domains on  [gi|491490529|ref|WP_005348265|]
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acetate kinase [Aeromonas diversa]

Protein Classification

acetate kinase( domain architecture ID 10011301)

acetate kinase catalyzes the production of acetyl-CoA by phosphorylating acetate in the presence of ATP; may act on propionate and/or other substrates as well

CATH:  3.30.420.40
EC:  2.7.2.1
Gene Ontology:  GO:0008776|GO:0016310|GO:0000287|GO:0006085|GO:0005524
PubMed:  16678422

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 3-399 0e+00

acetate kinase A/propionate kinase 2; Reviewed


:

Pssm-ID: 234680  Cd Length: 402  Bit Score: 701.87  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529   3 KLVLILNCGSSSLKFAVMDAETGEASLSGLAECFNLDDARIKWKLNGVKGEAMLGAGAAHQEALDFIVNHILSQDPSL-- 80
Cdd:PRK00180   1 MKILVLNAGSSSLKFQLIDMPNEEVLASGLVERIGLPDSRIKIKVDGGEKEEEELPIPDHAEALKFLLNTLTDGKLGLik 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529  81 -AAQLVAIGHRIVHGGERFSSSVRVDDEVIAGIEAAIPFAPLHNPAHLIGIRAALKVFPQLadKNVAVFDTAFHQSLPEE 159
Cdd:PRK00180  81 dLDEITAVGHRVVHGGEKFTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNV--PQVAVFDTAFHQTMPEE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529 160 AYLYALPYKLYEQHAIRRYGAHGTSHRFIAEEAAKALNKPLDELNIINCHLGNGASVCAIKGGKSVDTSMGLTPLEGLAM 239
Cdd:PRK00180 159 AYLYALPYELYEKYGIRRYGFHGTSHRYVSQRAAELLGKPLEELNLITCHLGNGASIAAIKNGKSVDTSMGFTPLEGLVM 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529 240 GTRSGDVDPAVVFFLHDKLGYSVDEINTLLTKQSGLLGLTEVSSDCRYATTNYDT-DAGAKRAVDVFTYRVAKYVGAYAA 318
Cdd:PRK00180 239 GTRSGDIDPAIIPYLMEKLGMSVDEIDNLLNKKSGLLGLSGVSSDMRDIEAAAEEgDERAKLALDVFVYRLAKYIGSYAA 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529 319 AMEGRLDALIFTGGIGENAAVIREMILARLALMGFKVDQEANKAAVLGGEGLITTADSR-PALVIPTNEELVIARDALAL 397
Cdd:PRK00180 319 ALNGRLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNLAARFGKEGDISTPDSKvKVLVIPTNEELMIARDTLRL 398


                 ..
gi 491490529 398 VG 399
Cdd:PRK00180 399 LG 400
 
Name Accession Description Interval E-value
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 3-399 0e+00

acetate kinase A/propionate kinase 2; Reviewed


Pssm-ID: 234680  Cd Length: 402  Bit Score: 701.87  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529   3 KLVLILNCGSSSLKFAVMDAETGEASLSGLAECFNLDDARIKWKLNGVKGEAMLGAGAAHQEALDFIVNHILSQDPSL-- 80
Cdd:PRK00180   1 MKILVLNAGSSSLKFQLIDMPNEEVLASGLVERIGLPDSRIKIKVDGGEKEEEELPIPDHAEALKFLLNTLTDGKLGLik 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529  81 -AAQLVAIGHRIVHGGERFSSSVRVDDEVIAGIEAAIPFAPLHNPAHLIGIRAALKVFPQLadKNVAVFDTAFHQSLPEE 159
Cdd:PRK00180  81 dLDEITAVGHRVVHGGEKFTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNV--PQVAVFDTAFHQTMPEE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529 160 AYLYALPYKLYEQHAIRRYGAHGTSHRFIAEEAAKALNKPLDELNIINCHLGNGASVCAIKGGKSVDTSMGLTPLEGLAM 239
Cdd:PRK00180 159 AYLYALPYELYEKYGIRRYGFHGTSHRYVSQRAAELLGKPLEELNLITCHLGNGASIAAIKNGKSVDTSMGFTPLEGLVM 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529 240 GTRSGDVDPAVVFFLHDKLGYSVDEINTLLTKQSGLLGLTEVSSDCRYATTNYDT-DAGAKRAVDVFTYRVAKYVGAYAA 318
Cdd:PRK00180 239 GTRSGDIDPAIIPYLMEKLGMSVDEIDNLLNKKSGLLGLSGVSSDMRDIEAAAEEgDERAKLALDVFVYRLAKYIGSYAA 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529 319 AMEGRLDALIFTGGIGENAAVIREMILARLALMGFKVDQEANKAAVLGGEGLITTADSR-PALVIPTNEELVIARDALAL 397
Cdd:PRK00180 319 ALNGRLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNLAARFGKEGDISTPDSKvKVLVIPTNEELMIARDTLRL 398


                 ..
gi 491490529 398 VG 399
Cdd:PRK00180 399 LG 400
AckA COG0282
Acetate kinase [Energy production and conversion];
3-399 0e+00

Acetate kinase [Energy production and conversion];


Pssm-ID: 440051  Cd Length: 395  Bit Score: 651.33  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529   3 KLVLILNCGSSSLKFAVMDAETGEASLSGLAECFNLDDARIKWKL-NGVKGEAMLgAGAAHQEALDFIVNHILSQDPSLA 81
Cdd:COG0282    1 MKILVLNAGSSSLKFQLFDMDSEEVLAKGLVERIGLPGARLKHKDaGGEKVEREL-PIPDHAAALALVLELLTDHGIIKD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529  82 -AQLVAIGHRIVHGGERFSSSVRVDDEVIAGIEAAIPFAPLHNPAHLIGIRAALKVFPQLadKNVAVFDTAFHQSLPEEA 160
Cdd:COG0282   80 lDEIDAVGHRVVHGGEKFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDL--PQVAVFDTAFHQTMPEVA 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529 161 YLYALPYKLYEQHAIRRYGAHGTSHRFIAEEAAKALNKPLDELNIINCHLGNGASVCAIKGGKSVDTSMGLTPLEGLAMG 240
Cdd:COG0282  158 YLYALPYELYEKYGIRRYGFHGTSHRYVAERAAELLGKPLADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVMG 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529 241 TRSGDVDPAVVFFLHDKLGYSVDEINTLLTKQSGLLGLTEVSSDCRYATTNYD-TDAGAKRAVDVFTYRVAKYVGAYAAA 319
Cdd:COG0282  238 TRSGDIDPGVVLYLMRKEGLSADEVDDLLNKESGLLGLSGISSDMRDLEEAAAsGDERARLALDMFVYRIKKYIGAYAAA 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529 320 MeGRLDALIFTGGIGENAAVIREMILARLALMGFKVDQEANKAAvlGGEGLITTADSR-PALVIPTNEELVIARDALALV 398
Cdd:COG0282  318 L-GGLDALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANAAR--GGERVISTPDSRvKVLVIPTNEELMIARDTLRLL 394


                 .
gi 491490529 399 G 399
Cdd:COG0282  395 K 395
ASKHA_NBD_AcK_PK cd24010
nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain ...
 5-397 0e+00

nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain family; The family corresponds to a group of proteins which transfer phosphate from ATP to a short chain aliphatic acid. It includes acetate kinase (AckA) and propionate kinase (TdcD and PduW). Acetate kinase (EC 2.7.2.1), also called acetokinase, catalyzes the formation of acetyl phosphate from acetate and ATP. It can also catalyze the reverse reaction in the presence of a divalent cation. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically. Propionate kinase TdcD (EC 2.7.2.15) catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor. The family also includes propionate kinase PduW (EC 2.7.2.15) that works with phosphate acetyltransferase (pta) to capture exogenous propionate and regenerate propionyl-CoA during degradation of propionate and 1,2-propanediol (1,2-PD). This protein restores growth to an eutQ deletion on ethanolamine and tetrathionate under anoxic conditions. The AcK/PK family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466860  Cd Length: 392  Bit Score: 612.98  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529   5 VLILNCGSSSLKFAVMDAETGEASLSGLAECFNLDDARIKWKLNGVKGEAMLGAGAAHQEALDFIVNHILSQDPSL-AAQ 83
Cdd:cd24010    1 ILVINCGSSSLKFQLFDMPTEEVLASGLVERIGLEGARLKHKVNNGEKIKEELPIPDHEEALKAILDTLTDPELGVsLDE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529  84 LVAIGHRIVHGGERFSSSVRVDDEVIAGIEAAIPFAPLHNPAHLIGIRAALKVFPQLadKNVAVFDTAFHQSLPEEAYLY 163
Cdd:cd24010   81 IDAVGHRVVHGGEKFTESVLIDDEVIAAIEDLSPLAPLHNPANLAGIEAARKLLPDV--PQVAVFDTAFHQTMPPHAYLY 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529 164 ALPYKLYEQHAIRRYGAHGTSHRFIAEEAAKALNKPLDELNIINCHLGNGASVCAIKGGKSVDTSMGLTPLEGLAMGTRS 243
Cdd:cd24010  159 ALPYELYEKYGIRRYGFHGTSHRYVSRRAAELLGKPLEDLNLITCHLGNGASICAIKNGKSVDTSMGLTPLEGLVMGTRS 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529 244 GDVDPAVVFFLHDKLGYSVDEINTLLTKQSGLLGLTEVSSDCRYATTNYDT-DAGAKRAVDVFTYRVAKYVGAYAAAMeG 322
Cdd:cd24010  239 GDIDPAIVFYLMKKEGMSVDEIERLLNKKSGLLGISGVSSDMRDIEEAAEEgDERAKLALDVFVYRIKKYIGAYAAAL-G 317

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491490529 323 RLDALIFTGGIGENAAVIREMILARLALMGFKVDQEANKAAVlGGEGLITTADSR-PALVIPTNEELVIARDALAL 397
Cdd:cd24010  318 GVDAIVFTGGIGENSALIRELVCEGLEFLGIELDEEKNKAAG-GGEREISTPDSKvKVLVIPTNEELMIARDTVRL 392
ackA TIGR00016
acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in ...
 1-397 0e+00

acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in the secretion of acetate. It catalyzes the reaction ATP + acetate = ADP + acetyl phosphate. Some members of this family have been shown to act on propionate as well as acetate. An example of a propionate/acetate kinase is TdcD of E. coli (SP|P11868), an enzyme of an anaerobic pathway of threonine catabolism. It is not known how many members of this family act on additional substrates besides acetate. [Energy metabolism, Fermentation]


Pssm-ID: 272856  Cd Length: 404  Bit Score: 590.54  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529    1 MSKLVLILNCGSSSLKFAVMDAETGEASL-SGLAECFNLDDARIKWKLNGVKGEAMLGAGAAHQEALDFIVNHILSQD-P 78
Cdd:TIGR00016   2 SSMKILVLNAGSSSLKFALFDAVNGEEVLaSGLAERIFLPNARIKWVEDGGKKEAELLAGADHQEALKFILNTLLKDKiI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529   79 SLAAQLVAIGHRIVHGGERFSSSVRVDDEVIAGIEAAIPFAPLHNPAHLIGIRAALKVFPQLADKNVAVFDTAFHQSLPE 158
Cdd:TIGR00016  82 KLLSEIDLIGHRVVHGGEKFTDSVIITDEVIQKIKDISPLAPLHNPAHLIGIEAALKLFPLPKAKNVAVFDTAFHQTMPE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529  159 EAYLYALPYKLYEQHAIRRYGAHGTSHRFIAEEAAKALNKPLDELNIINCHLGNGASVCAIKGGKSVDTSMGLTPLEGLA 238
Cdd:TIGR00016 162 EAYLYALPYSWYKEHGVRRYGFHGTSHKYVTQRAAKILNKPLDDLNLIVCHLGNGASVCAIKNGKSIDTSMGFTPLEGLM 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529  239 MGTRSGDVDPAVVFFLHDKLGYSVDEINTLLTKQSGLLGLTEVSSDCRYATTNYD-TDAGAKRAVDVFTYRVAKYVGAYA 317
Cdd:TIGR00016 242 MGTRSGDIDPAIIFYLAETLGMSADDIENTLNKKSGLLGISGLSSDLRDIEDAYAeGNEQAKLAIKVYVHRIAKYIGSYI 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529  318 AAMEGRLDALIFTGGIGENAAVIREMILARLALMGFKVDQEANKAAVLGGEGLITTADSR-PALVIPTNEELVIARDALA 396
Cdd:TIGR00016 322 ASLEGNLDAIVFTGGIGENAAMVRELVLEKLEVLGFELDPELNNAARSGKSGVISTPESKvKILVIPTNEELMIAQDAIR 401


                  .
gi 491490529  397 L 397
Cdd:TIGR00016 402 L 402
Acetate_kinase pfam00871
Acetokinase family; This family includes acetate kinase, butyrate kinase and ...
 4-392 0e+00

Acetokinase family; This family includes acetate kinase, butyrate kinase and 2-methylpropanoate kinase.


Pssm-ID: 395700  Cd Length: 387  Bit Score: 567.44  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529    4 LVLILNCGSSSLKFAVMDAETGEASLSGLAECFNLDDARIKWKLNGVKGEAMLGAGAAHQEALDFIVNHILSQD-PSLAA 82
Cdd:pfam00871   1 KVLVLNAGSSSIKFQLFDAVIGEVLLSGLAERIGLPNARILWKMNGGKKNAALLAGADHSEALNFILNTLLKHKiIELLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529   83 QLVAIGHRIVHGGERFSSSVRVDDEVIAGIEAAIPFAPLHNPAHLIGIRAALKVFPQLadKNVAVFDTAFHQSLPEEAYL 162
Cdd:pfam00871  81 EITLIGHRVVHGGEKFTESVLITDEVIQGIKDLIPLAPLHNPAHLDGIEEAFKLFPQV--KNVAVFDTAFHQTMPEEAYL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529  163 YALPYKLYEQHAIRRYGAHGTSHRFIAEEAAKALNKPLDELNIINCHLGNGASVCAIKGGKSVDTSMGLTPLEGLAMGTR 242
Cdd:pfam00871 159 YALPYSWYKEHGIRRYGFHGTSHKYVSQRAAKILNKPLEDLNLITCHLGNGASVCAVRNGKSVDTSMGFTPLEGLVMGTR 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529  243 SGDVDPAVVFFLHDKLGYSVDEINTLLTKQSGLLGLTEVSSDCRYATTNYD-TDAGAKRAVDVFTYRVAKYVGAYAAAME 321
Cdd:pfam00871 239 SGDIDPAIIFYLAETLGMSADEINNTLNKKSGLLGLSGVSSDLRYVEDAYAeGKEDAQLAIKVYVHRLAKYIGSYAASLE 318

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491490529  322 gRLDALIFTGGIGENAAVIREMILARLALMGFKVDQEANKaaVLGGEGLITTADSR-PALVIPTNEELVIAR 392
Cdd:pfam00871 319 -RLDAIVFTGGIGENAAMVRELVLNALEVLGFEIDPERNN--RFGKSGVISTEDSRvKVVVIPTNEELMIAQ 387
 
Name Accession Description Interval E-value
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 3-399 0e+00

acetate kinase A/propionate kinase 2; Reviewed


Pssm-ID: 234680  Cd Length: 402  Bit Score: 701.87  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529   3 KLVLILNCGSSSLKFAVMDAETGEASLSGLAECFNLDDARIKWKLNGVKGEAMLGAGAAHQEALDFIVNHILSQDPSL-- 80
Cdd:PRK00180   1 MKILVLNAGSSSLKFQLIDMPNEEVLASGLVERIGLPDSRIKIKVDGGEKEEEELPIPDHAEALKFLLNTLTDGKLGLik 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529  81 -AAQLVAIGHRIVHGGERFSSSVRVDDEVIAGIEAAIPFAPLHNPAHLIGIRAALKVFPQLadKNVAVFDTAFHQSLPEE 159
Cdd:PRK00180  81 dLDEITAVGHRVVHGGEKFTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNV--PQVAVFDTAFHQTMPEE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529 160 AYLYALPYKLYEQHAIRRYGAHGTSHRFIAEEAAKALNKPLDELNIINCHLGNGASVCAIKGGKSVDTSMGLTPLEGLAM 239
Cdd:PRK00180 159 AYLYALPYELYEKYGIRRYGFHGTSHRYVSQRAAELLGKPLEELNLITCHLGNGASIAAIKNGKSVDTSMGFTPLEGLVM 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529 240 GTRSGDVDPAVVFFLHDKLGYSVDEINTLLTKQSGLLGLTEVSSDCRYATTNYDT-DAGAKRAVDVFTYRVAKYVGAYAA 318
Cdd:PRK00180 239 GTRSGDIDPAIIPYLMEKLGMSVDEIDNLLNKKSGLLGLSGVSSDMRDIEAAAEEgDERAKLALDVFVYRLAKYIGSYAA 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529 319 AMEGRLDALIFTGGIGENAAVIREMILARLALMGFKVDQEANKAAVLGGEGLITTADSR-PALVIPTNEELVIARDALAL 397
Cdd:PRK00180 319 ALNGRLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNLAARFGKEGDISTPDSKvKVLVIPTNEELMIARDTLRL 398


                 ..
gi 491490529 398 VG 399
Cdd:PRK00180 399 LG 400
AckA COG0282
Acetate kinase [Energy production and conversion];
3-399 0e+00

Acetate kinase [Energy production and conversion];


Pssm-ID: 440051  Cd Length: 395  Bit Score: 651.33  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529   3 KLVLILNCGSSSLKFAVMDAETGEASLSGLAECFNLDDARIKWKL-NGVKGEAMLgAGAAHQEALDFIVNHILSQDPSLA 81
Cdd:COG0282    1 MKILVLNAGSSSLKFQLFDMDSEEVLAKGLVERIGLPGARLKHKDaGGEKVEREL-PIPDHAAALALVLELLTDHGIIKD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529  82 -AQLVAIGHRIVHGGERFSSSVRVDDEVIAGIEAAIPFAPLHNPAHLIGIRAALKVFPQLadKNVAVFDTAFHQSLPEEA 160
Cdd:COG0282   80 lDEIDAVGHRVVHGGEKFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDL--PQVAVFDTAFHQTMPEVA 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529 161 YLYALPYKLYEQHAIRRYGAHGTSHRFIAEEAAKALNKPLDELNIINCHLGNGASVCAIKGGKSVDTSMGLTPLEGLAMG 240
Cdd:COG0282  158 YLYALPYELYEKYGIRRYGFHGTSHRYVAERAAELLGKPLADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVMG 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529 241 TRSGDVDPAVVFFLHDKLGYSVDEINTLLTKQSGLLGLTEVSSDCRYATTNYD-TDAGAKRAVDVFTYRVAKYVGAYAAA 319
Cdd:COG0282  238 TRSGDIDPGVVLYLMRKEGLSADEVDDLLNKESGLLGLSGISSDMRDLEEAAAsGDERARLALDMFVYRIKKYIGAYAAA 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529 320 MeGRLDALIFTGGIGENAAVIREMILARLALMGFKVDQEANKAAvlGGEGLITTADSR-PALVIPTNEELVIARDALALV 398
Cdd:COG0282  318 L-GGLDALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANAAR--GGERVISTPDSRvKVLVIPTNEELMIARDTLRLL 394


                 .
gi 491490529 399 G 399
Cdd:COG0282  395 K 395
ASKHA_NBD_AcK_PK cd24010
nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain ...
 5-397 0e+00

nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain family; The family corresponds to a group of proteins which transfer phosphate from ATP to a short chain aliphatic acid. It includes acetate kinase (AckA) and propionate kinase (TdcD and PduW). Acetate kinase (EC 2.7.2.1), also called acetokinase, catalyzes the formation of acetyl phosphate from acetate and ATP. It can also catalyze the reverse reaction in the presence of a divalent cation. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically. Propionate kinase TdcD (EC 2.7.2.15) catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor. The family also includes propionate kinase PduW (EC 2.7.2.15) that works with phosphate acetyltransferase (pta) to capture exogenous propionate and regenerate propionyl-CoA during degradation of propionate and 1,2-propanediol (1,2-PD). This protein restores growth to an eutQ deletion on ethanolamine and tetrathionate under anoxic conditions. The AcK/PK family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466860  Cd Length: 392  Bit Score: 612.98  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529   5 VLILNCGSSSLKFAVMDAETGEASLSGLAECFNLDDARIKWKLNGVKGEAMLGAGAAHQEALDFIVNHILSQDPSL-AAQ 83
Cdd:cd24010    1 ILVINCGSSSLKFQLFDMPTEEVLASGLVERIGLEGARLKHKVNNGEKIKEELPIPDHEEALKAILDTLTDPELGVsLDE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529  84 LVAIGHRIVHGGERFSSSVRVDDEVIAGIEAAIPFAPLHNPAHLIGIRAALKVFPQLadKNVAVFDTAFHQSLPEEAYLY 163
Cdd:cd24010   81 IDAVGHRVVHGGEKFTESVLIDDEVIAAIEDLSPLAPLHNPANLAGIEAARKLLPDV--PQVAVFDTAFHQTMPPHAYLY 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529 164 ALPYKLYEQHAIRRYGAHGTSHRFIAEEAAKALNKPLDELNIINCHLGNGASVCAIKGGKSVDTSMGLTPLEGLAMGTRS 243
Cdd:cd24010  159 ALPYELYEKYGIRRYGFHGTSHRYVSRRAAELLGKPLEDLNLITCHLGNGASICAIKNGKSVDTSMGLTPLEGLVMGTRS 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529 244 GDVDPAVVFFLHDKLGYSVDEINTLLTKQSGLLGLTEVSSDCRYATTNYDT-DAGAKRAVDVFTYRVAKYVGAYAAAMeG 322
Cdd:cd24010  239 GDIDPAIVFYLMKKEGMSVDEIERLLNKKSGLLGISGVSSDMRDIEEAAEEgDERAKLALDVFVYRIKKYIGAYAAAL-G 317

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491490529 323 RLDALIFTGGIGENAAVIREMILARLALMGFKVDQEANKAAVlGGEGLITTADSR-PALVIPTNEELVIARDALAL 397
Cdd:cd24010  318 GVDAIVFTGGIGENSALIRELVCEGLEFLGIELDEEKNKAAG-GGEREISTPDSKvKVLVIPTNEELMIARDTVRL 392
ackA TIGR00016
acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in ...
 1-397 0e+00

acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in the secretion of acetate. It catalyzes the reaction ATP + acetate = ADP + acetyl phosphate. Some members of this family have been shown to act on propionate as well as acetate. An example of a propionate/acetate kinase is TdcD of E. coli (SP|P11868), an enzyme of an anaerobic pathway of threonine catabolism. It is not known how many members of this family act on additional substrates besides acetate. [Energy metabolism, Fermentation]


Pssm-ID: 272856  Cd Length: 404  Bit Score: 590.54  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529    1 MSKLVLILNCGSSSLKFAVMDAETGEASL-SGLAECFNLDDARIKWKLNGVKGEAMLGAGAAHQEALDFIVNHILSQD-P 78
Cdd:TIGR00016   2 SSMKILVLNAGSSSLKFALFDAVNGEEVLaSGLAERIFLPNARIKWVEDGGKKEAELLAGADHQEALKFILNTLLKDKiI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529   79 SLAAQLVAIGHRIVHGGERFSSSVRVDDEVIAGIEAAIPFAPLHNPAHLIGIRAALKVFPQLADKNVAVFDTAFHQSLPE 158
Cdd:TIGR00016  82 KLLSEIDLIGHRVVHGGEKFTDSVIITDEVIQKIKDISPLAPLHNPAHLIGIEAALKLFPLPKAKNVAVFDTAFHQTMPE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529  159 EAYLYALPYKLYEQHAIRRYGAHGTSHRFIAEEAAKALNKPLDELNIINCHLGNGASVCAIKGGKSVDTSMGLTPLEGLA 238
Cdd:TIGR00016 162 EAYLYALPYSWYKEHGVRRYGFHGTSHKYVTQRAAKILNKPLDDLNLIVCHLGNGASVCAIKNGKSIDTSMGFTPLEGLM 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529  239 MGTRSGDVDPAVVFFLHDKLGYSVDEINTLLTKQSGLLGLTEVSSDCRYATTNYD-TDAGAKRAVDVFTYRVAKYVGAYA 317
Cdd:TIGR00016 242 MGTRSGDIDPAIIFYLAETLGMSADDIENTLNKKSGLLGISGLSSDLRDIEDAYAeGNEQAKLAIKVYVHRIAKYIGSYI 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529  318 AAMEGRLDALIFTGGIGENAAVIREMILARLALMGFKVDQEANKAAVLGGEGLITTADSR-PALVIPTNEELVIARDALA 396
Cdd:TIGR00016 322 ASLEGNLDAIVFTGGIGENAAMVRELVLEKLEVLGFELDPELNNAARSGKSGVISTPESKvKILVIPTNEELMIAQDAIR 401


                  .
gi 491490529  397 L 397
Cdd:TIGR00016 402 L 402
Acetate_kinase pfam00871
Acetokinase family; This family includes acetate kinase, butyrate kinase and ...
 4-392 0e+00

Acetokinase family; This family includes acetate kinase, butyrate kinase and 2-methylpropanoate kinase.


Pssm-ID: 395700  Cd Length: 387  Bit Score: 567.44  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529    4 LVLILNCGSSSLKFAVMDAETGEASLSGLAECFNLDDARIKWKLNGVKGEAMLGAGAAHQEALDFIVNHILSQD-PSLAA 82
Cdd:pfam00871   1 KVLVLNAGSSSIKFQLFDAVIGEVLLSGLAERIGLPNARILWKMNGGKKNAALLAGADHSEALNFILNTLLKHKiIELLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529   83 QLVAIGHRIVHGGERFSSSVRVDDEVIAGIEAAIPFAPLHNPAHLIGIRAALKVFPQLadKNVAVFDTAFHQSLPEEAYL 162
Cdd:pfam00871  81 EITLIGHRVVHGGEKFTESVLITDEVIQGIKDLIPLAPLHNPAHLDGIEEAFKLFPQV--KNVAVFDTAFHQTMPEEAYL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529  163 YALPYKLYEQHAIRRYGAHGTSHRFIAEEAAKALNKPLDELNIINCHLGNGASVCAIKGGKSVDTSMGLTPLEGLAMGTR 242
Cdd:pfam00871 159 YALPYSWYKEHGIRRYGFHGTSHKYVSQRAAKILNKPLEDLNLITCHLGNGASVCAVRNGKSVDTSMGFTPLEGLVMGTR 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529  243 SGDVDPAVVFFLHDKLGYSVDEINTLLTKQSGLLGLTEVSSDCRYATTNYD-TDAGAKRAVDVFTYRVAKYVGAYAAAME 321
Cdd:pfam00871 239 SGDIDPAIIFYLAETLGMSADEINNTLNKKSGLLGLSGVSSDLRYVEDAYAeGKEDAQLAIKVYVHRLAKYIGSYAASLE 318

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491490529  322 gRLDALIFTGGIGENAAVIREMILARLALMGFKVDQEANKaaVLGGEGLITTADSR-PALVIPTNEELVIAR 392
Cdd:pfam00871 319 -RLDAIVFTGGIGENAAMVRELVLNALEVLGFEIDPERNN--RFGKSGVISTEDSRvKVVVIPTNEELMIAQ 387
PRK12440 PRK12440
acetate/propionate family kinase;
4-398 3.12e-157

acetate/propionate family kinase;


Pssm-ID: 183528  Cd Length: 397  Bit Score: 448.54  E-value: 3.12e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529   4 LVLILNCGSSSLKFAVMDAETGEASLSGLAECFNLDDARIKWKLNGVKGE-AMLGAGAAHQEALDFIVNhiLSQDPSLAA 82
Cdd:PRK12440   5 YVLVINSGSSSLKFAVIDSVTGEAVLSGLGECFGLEDARMSWKYQGEKTEiAIEGEDNHHKIAIGRLVG--LTEELGFTQ 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529  83 QLVAIGHRIVHGGERFSSSVRVDDEVIAGIEAAIPFAPLHNPAHLIGIRAALKVFPQLAdkNVAVFDTAFHQSLPEEAYL 162
Cdd:PRK12440  83 DIVAVGHRIVHGGEKFTSTVRIDEEVTAEIESLSDLAPLHNPAGAIGIRAAMAAFPSLP--QFAVFDTAFHQTMPKKAFT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529 163 YALPYKLYEQHAIRRYGAHGTSHRFIAEEAAKALNKPLDELNIINCHLGNGASVCAIKGGKSVDTSMGLTPLEGLAMGTR 242
Cdd:PRK12440 161 GAIAKELYTDFGIRRYGFHGTSHYFVSREAAKMLNKPIEESSFISVHLGNGASVCAIKNGQSVDTSMGFTPLSGLMMGTR 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529 243 SGDVDPAVVFFLHDKlGYSVDEINTLLTKQSGLLGLTEVSSDCRYATTNYDT-DAGAKRAVDVFTYRVAKYVGAYAAAME 321
Cdd:PRK12440 241 CGDLDPGIIEFLLKK-GWSQEKVFNSLNKKSGFLGVSGLTSDARGILEAMEEgHEGATLAFEVFTYRVAKYIASYLAALD 319

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491490529 322 gRLDALIFTGGIGENAAVIREMILARLALMGFKVDQEANKAAVLGGEGLITTAD--SRPALVIPTNEELVIARDALALV 398
Cdd:PRK12440 320 -SLDGIIFTGGIGENSLPIRREILKNLKLLGFVEDEKGNEDARFGKAGIIAKSEllNAVAMVIPTNEEFVIAQQSVELL 397
PRK12379 PRK12379
propionate kinase;
4-397 1.69e-146

propionate kinase;


Pssm-ID: 183484  Cd Length: 396  Bit Score: 421.07  E-value: 1.69e-146
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529   4 LVLILNCGSSSLKFAVMDAETGEASLSGLAECFNLDDARIKwkLNGvkGEAMLGAGAAHQEALDFIVNHILSQDpsLAAQ 83
Cdd:PRK12379   6 VVLVINCGSSSIKFSVLDASDCEVLMSGIADGINSENAFLS--VNG--GEPAPLAHHSYEGALKAIAFELEKRN--LNDS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529  84 LVAIGHRIVHGGERFSSSVRVDDEVIAGIEAAIPFAPLHNPAHLIGIRAALKVFPQLadKNVAVFDTAFHQSLPEEAYLY 163
Cdd:PRK12379  80 VALIGHRIAHGGSIFTESVIITDEVIDNIRRVSPLAPLHNYANLSGIEAAQQLFPGV--TQVAVFDTSFHQTLAPEAYLY 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529 164 ALPYKLYEQHAIRRYGAHGTSHRFIAEEAAKALNKPLDELNIINCHLGNGASVCAIKGGKSVDTSMGLTPLEGLAMGTRS 243
Cdd:PRK12379 158 GLPWEYYEELGVRRYGFHGTSHRYVSQRAHSLLNLDEDDSGLVVAHLGNGASICAVRNGQSVDTSMGMTPLEGLMMGTRS 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529 244 GDVDPAVVFFLHDKLGYSVDEINTLLTKQSGLLGLTEVSSDCRYATTNYDT-DAGAKRAVDVFTYRVAKYVGAYAAAMEg 322
Cdd:PRK12379 238 GDVDFGAMAWIASQTGQTLGDLERVVNKESGLLGISGLSSDLRVLEKAWHEgHERAQLAIKTFVHRIARHIAGHAASLH- 316

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491490529 323 RLDALIFTGGIGENAAVIREMILARLALMGFKVDQEANKAAVLGGEGLITTADSR-PALVIPTNEELVIARDALAL 397
Cdd:PRK12379 317 RLDGIIFTGGIGENSSLIRRLVMEHLAVLGLEIDTEMNNQPNSGGERIISSENSRvICAVIPTNEEKMIALDAIHL 392
PRK07157 PRK07157
acetate kinase; Provisional
 1-397 2.78e-127

acetate kinase; Provisional


Pssm-ID: 235948  Cd Length: 400  Bit Score: 372.54  E-value: 2.78e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529   1 MSKLVLILNCGSSSLKFAVMDAETGEASLSGLAECFNLDDARIKWKLNGVKGEAMLGAgAAHQEALDFIV----NHILSQ 76
Cdd:PRK07157   1 MKAKILVINAGSSSIKWQLFDKENLNLIASGLAERIGLENGLIKIKFGKKKYEKEVDM-PNHKVAVAVLIeiweENKLIE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529  77 DPSlaaQLVAIGHRIVHGGERFSSSVRVDDEVIAGIEAAIPFAPLHNPAHLIGIRAALKVFPQLadKNVAVFDTAFHQSL 156
Cdd:PRK07157  80 DLE---EIELIGFRVVHGGDYFNGPTKLDDKEISKIEKVAKYAPLHNPGALQTIKAFKKVLPKA--KLSASFDTAFHTSI 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529 157 PEEAYLYALPYKLYEQHAIRRYGAHGTSHRFIAEEAAKALNKplDELNIINCHLGNGASVCAIKGGKSVDTSMGLTPLEG 236
Cdd:PRK07157 155 PKINYTYPINYEIAKKYGIKKYGFHGISHKFITNKVEKILNK--DKVNFVNLHIGNGASLCAIKNSKSIDTSMGLTPLAG 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529 237 LAMGTRSGDVDPAVVFFLHDKLGYSVDEINTLLTKQSGLLGLTEVSSDCRYATTNY-DTDAGAKRAVDVFTYRVAKYVGA 315
Cdd:PRK07157 233 VMMGTRSGDIDPSIHEFVAKEANMSISEFTDLLNKKSGLLGVSGISSDLRDVIKAAeSGNKRAKFALDLYAQKIVDYLAN 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529 316 YAAAMEGRLDALIFTGGIGENAAVIREMILARLALMGFKVDQEAN--KAAVLGGEGLITTADSR-PALVIPTNEELVIAR 392
Cdd:PRK07157 313 YINKIGKKIDAIVFTAGVGENSAFVRELVINKINIPNIKLDKEKNlkKIGEYGPIELISTPDSDiPVYVIRTNEELLIAK 392


                 ....*
gi 491490529 393 DALAL 397
Cdd:PRK07157 393 NAIKL 397
PRK12397 PRK12397
acetate/propionate family kinase;
1-395 1.38e-122

acetate/propionate family kinase;


Pssm-ID: 183500  Cd Length: 404  Bit Score: 360.69  E-value: 1.38e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529   1 MSKLVLILNCGSSSLKFAVMDAETGEASLSGLAECFNLDDARIKWKLNGVKGEAMLgAGAAHQEALDFIVNHILSQD--P 78
Cdd:PRK12397   1 MSYKIMAINAGSSSLKFQLLEMPQGDMLCQGLIERIGMADAQVTIKTHSQKWQETV-PVADHRDAVTLLLEKLLGYQiiN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529  79 SLAaQLVAIGHRIVHGGERFSSSVRVDDEVIAGIEAAIPFAPLHNPAHLIGIRAALKVFPqlADKNVAVFDTAFHQSLPE 158
Cdd:PRK12397  80 SLR-DIDGVGHRVAHGGEFFKDSTLVTDETLAQIERLAELAPLHNPVNALGIHVFRQLLP--DAPSVAVFDTAFHQTLDE 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529 159 EAYLYALPYKLYEQHAIRRYGAHGTSHRFIAEEAAKALNKPLDELNIINCHLGNGASVCAIKGGKSVDTSMGLTPLEGLA 238
Cdd:PRK12397 157 PAYIYPLPWRYYAELGIRRYGFHGTSHKYVSGVLAEKLGVPLSALRVICCHLGNGSSICAIKNGRSVNTSMGFTPQSGVM 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529 239 MGTRSGDVDPAVVFFLHDKLGYSVDEINTLLTKQSGLLGLTEVSSDcrYATTNYDTDAGAKR---AVDVFTYRVAKYVGA 315
Cdd:PRK12397 237 MGTRSGDIDPSILPWIAQREGKTPQQLNQLLNNESGLLGVSGVSSD--YRDVEQAANTGNRQaklALTLFAERIRATIGS 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529 316 YAAAMEGrLDALIFTGGIGENAAVIREMILARLALMGFKVDQEANKAavlggEGLITTADSRPA--LVIPTNEELVIARD 393
Cdd:PRK12397 315 YIMQMGG-LDALVFTGGIGENSARARSAVCHNLQFLGLAVDEEKNQR-----NATFIQTENALVkvAVINTNEELMIAQD 388


                 ..
gi 491490529 394 AL 395
Cdd:PRK12397 389 VM 390
PRK07058 PRK07058
acetate/propionate family kinase;
1-399 7.99e-100

acetate/propionate family kinase;


Pssm-ID: 235922  Cd Length: 396  Bit Score: 302.35  E-value: 7.99e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529   1 MSKLVLILNCGSSSLKFAVMDAETGEASLSGLAEcfnLDDARIKWKLNGVKG----EAMLGAGAAHQ------EALDFIV 70
Cdd:PRK07058   2 SKPLLLTFNAGSSTVKIGLFEVDGNEARRIGKGD---IDFRRAPLRFHLRNGgetlDIPLKASVTDDlhtvldETFDWLA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529  71 NHIlsqDPslaAQLVAIGHRIVHGGERFSSSVRVDDEVIAGIEAAIPFAPLHNPAHLIGIRAALKVFPQLAdkNVAVFDT 150
Cdd:PRK07058  79 AHF---DV---SELVAVGHRVVHGGDRFAGAVLIDDATLDAIEALVPLAPLHQPQSLRLIRAIRHLRPHLP--QTASFDT 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529 151 AFHQSLPEEAYLYALPYKLYEqHAIRRYGAHGTSHRFIAEEAAKaLNKPLDELNIINCHLGNGASVCAIKGGKSVDTSMG 230
Cdd:PRK07058 151 AFHRTQPDLVRRFAIPRALHD-EGIKRYGFHGLSYKFVAGELRR-RAPELARGKVVAAHLGSGASLCALDAGKSRDTSMG 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529 231 LTPLEGLAMGTRSGDVDPAVVFFLHDKLGYSVDEINTLLTKQSGLLGLTEVSSDCRYATTnyDTDAGAKRAVDVFTYRVA 310
Cdd:PRK07058 229 FSTLDGIPMATRCGALDPGVVLHLLKQEGMSLDEVEDLLYHRSGLLGVSGISGDTRDLLA--SDAPEAREALDLFALRIA 306

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529 311 KYVGAYAAAMEGrLDALIFTGGIGENAAVIREMILARLALMGFKVDQEANKAavlgGEGLITTADSR-PALVIPTNEELV 389
Cdd:PRK07058 307 GEIARLAATLGG-LDAVVFTAGIGEHQPAIRAAVCERLAWLGVELDPAANAA----NAFTISSRTSRvAAFVIPTDEEQV 381

                        410
                 ....*....|
gi 491490529 390 IARDALALVG 399
Cdd:PRK07058 382 IADEAFSVLR 391
ASKHA_NBD_BK cd24011
nucleotide-binding domain (NBD) of the butyrate kinase (BK) domain family; Butyrate kinase (EC ...
 176-349 2.43e-26

nucleotide-binding domain (NBD) of the butyrate kinase (BK) domain family; Butyrate kinase (EC 2.7.2.7) catalyzes the formation of butyryl-CoA by phosphorylating butyrate in the presence of ATP to form butyryl phosphate. Butyrate kinases exist in many fermentative species of the bacterial and archaeal families. They belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466861  Cd Length: 345  Bit Score: 108.01  E-value: 2.43e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529 176 RRYGAHGTSHRFIAEEAAKALNKPLDELNIINCHLGNGASVCAIKGGKSVDTSMGLtPLEGLaMGT-RSGDVDPAVVFFL 254
Cdd:cd24011  147 RRSIFHALNQKAVARRAAKELGKPYEELNLIVAHLGGGISVGAHRKGRVIDVNNAL-DGEGP-FSPeRAGTLPVGDLIKL 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529 255 HDKLGYSVDEINTLLTKQSGLLGLTEVsSDCRYATTNYDT-DAGAKRAVDVFTYRVAKYVGAYAAAMEGRLDALIFTGGI 333
Cdd:cd24011  225 CFSGKYTLEELKKKLKGKGGLVAYLGT-NDFREVEKRIEAgDEKAKLVLDAMAYQIAKEIGALAAVLKGKVDAIILTGGL 303

                        170
                 ....*....|....*.
gi 491490529 334 GeNAAVIREMILARLA 349
Cdd:cd24011  304 A-YSKRLVDRIKERVG 318
PRK03011 PRK03011
butyrate kinase; Provisional
 176-349 4.38e-23

butyrate kinase; Provisional


Pssm-ID: 235099  Cd Length: 358  Bit Score: 99.08  E-value: 4.38e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529 176 RRYGAHGTSHRFIAEEAAKALNKPLDELNIINCHLGNGASVCAIKGGKSVDTSMGLtPLEGLAMGTRSGDVdPA--VVff 253
Cdd:PRK03011 149 RKSIFHALNQKAVARRVAKELGKKYEELNLIVAHLGGGISVGAHRKGRVIDVNNAL-DGEGPFSPERAGGL-PVgdLV-- 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491490529 254 lhdKLGYSV----DEINTLLTKQSGLLGLTEvSSDCRYATTNYD-TDAGAKRAVDVFTYRVAKYVGAYAAAMEGRLDALI 328
Cdd:PRK03011 225 ---ELCFSGkytkEELKKKLVGKGGLVAYLG-TNDAREVEKRIEeGDEKAKLVYEAMAYQIAKEIGAMAAVLKGKVDAIV 300

                        170       180
                 ....*....|....*....|.
gi 491490529 329 FTGGIGENAAVIrEMILARLA 349
Cdd:PRK03011 301 LTGGLAYSKRLV-ERIKERVS 320
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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