|
Name |
Accession |
Description |
Interval |
E-value |
| pcnB |
TIGR01942 |
poly(A) polymerase; This model describes the pcnB family of poly(A) polymerases (also known as ... |
6-413 |
1.92e-107 |
|
poly(A) polymerase; This model describes the pcnB family of poly(A) polymerases (also known as plasmid copy number protein). These enzymes sequentially add adenosine nucleotides to the 3' end of RNAs, targeting them for degradation by the cell. This was originally described for anti-sense RNAs, but was later demonstrated for mRNAs as well. Members of this family are as yet limited to the gamma- and beta-proteobacteria, with putative members in the Chlamydiacae and spirochetes. This family has homology to tRNA nucleotidyltransferase (cca).
Pssm-ID: 130997 [Multi-domain] Cd Length: 410 Bit Score: 325.60 E-value: 1.92e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 6 ASKCGLSTTQLPAYILDVIDALTKAGYEAYIVGGGVRDLMLGLNPKDFDAVTNATPSQVKEVFGRRCRIIGRrFELAHVY 85
Cdd:TIGR01942 4 ESEHNIPRQSFSAHALNVVERLKGAGYQAYIVGGAVRDLLLGIEPKDFDVVTSATPEEVRKLFRNSRIVGRR-FRLVHVS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 86 SGRELVEVATFRAPPKRAVtSAAGMILRDNNWGTIEQDFARRDFSINALYYQPRKGIVLDFCHAVDDIKSKTLRLLGDPT 165
Cdd:TIGR01942 83 FGRQIIEVATFRSGHKSSV-NAEGRILKDNVYGTLEEDAWRRDFTVNALYYDPSREVIIDYVGGMEDLKNRRLRLIGDPR 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 166 VRFEEDPVRMLRTLRFAAKLNFNIDPAILEIFTpEMTQLLRDVSPHRLYDESQKLFTMGHLNRVLPMLIDFgiwrQLFAD 245
Cdd:TIGR01942 162 SRYQEDPVRMLRALRFSVKLEFTIDESTARPIR-ESAPLLKGIPPARLFEEILKLLFSGRSAALFRMLCGY----QLLEP 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 246 IKPDITPFIELAAK------------NTDQRIAIGKTINPAFFYAVLLWKPFLERCDFYLSKGVIPAEARAQAGLDVLKR 313
Cdd:TIGR01942 237 LFPSVAYALRESPKfesaftvqalvnDTDFRVKRDKPVTPAFLYAALLWPGLVFRVADAPDQGVMPYPAVFDAIRDFVEE 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 314 QATRTVIPRFAETFIREVWEMQTRLLNPKPQQIAALSNHARFRAGFDFLLLRERSGDAqTQEMGTWWDQYQTmsTDEKER 393
Cdd:TIGR01942 317 QCAPISIPKRFSIPTREIWQMQLRLERRSGMRARKLLGHARFRAAYDLLLLREVCGRE-NAVLGEWWTPYQL--ASEEER 393
|
410 420
....*....|....*....|
gi 491324444 394 aigqynRQRAKSRRKAAQEE 413
Cdd:TIGR01942 394 ------TEMTRSAARHEGNR 407
|
|
| pcnB |
PRK11623 |
poly(A) polymerase I; Provisional |
21-413 |
1.54e-91 |
|
poly(A) polymerase I; Provisional
Pssm-ID: 236939 [Multi-domain] Cd Length: 472 Bit Score: 286.65 E-value: 1.54e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 21 LDVIDALTKAGYEAYIVGGGVRDLMLGLNPKDFDAVTNATPSQVKEVFGRRCRIIGRrFELAHVYSGRELVEVATFRAPP 100
Cdd:PRK11623 56 LKVLYRLNKAGYEAYLVGGGVRDLLLGKKPKDFDVTTNATPEQVRKLFRNCRLVGRR-FRLAHVMFGPEIIEVATFRGHH 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 101 KRAVTSAA-------GMILRDNNWGTIEQDFARRDFSINALYYQPRKGIVLDFCHAVDDIKSKTLRLLGDPTVRFEEDPV 173
Cdd:PRK11623 135 EGNESDRNtsqrgqnGMLLRDNIFGSIEEDAQRRDFTINSLYYSVADFTVRDYVGGMKDLKEGVIRLIGNPETRYREDPV 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 174 RMLRTLRFAAKLNFNIDPAILEIFtPEMTQLLRDVSPHRLYDESQKLFTMGHLNRVLPMLIDFGIWRQLFADIKPDITP- 252
Cdd:PRK11623 215 RMLRAVRFAAKLDMRISPETAEPI-PRLATLLNDIPPARLFEESLKLLQAGYGYETYKLLCEYHLFQPLFPTITRYFTEn 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 253 -------FIELAAKNTDQRIAIGKTINPAFFYAVLLWKPFLERCD-FYLSKGVIPAEARAQAGLDVLKRQATRTVIPRFA 324
Cdd:PRK11623 294 gdspmerIIEQVLKNTDTRIHNDMRVNPAFLFAAMFWYPLLEHAQkIAQESGLAYYDAFALAMNDVLDEACRSLAIPKRL 373
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 325 ETFIREVWEMQTRLLNPKPQQIAALSNHARFRAGFDFLLLR-ERSGDAQTQEMGTWWDQYQTMSTDEKERAIGQYN---- 399
Cdd:PRK11623 374 TTLTRDIWQLQLRMSRRQGKRAWKLMEHPKFRAAYDLLALRaEVENNAELQRLAQWWGEFQVSAPPQQKGMLNELDddpa 453
|
410
....*....|....*.
gi 491324444 400 --RQRAKSRRKAAQEE 413
Cdd:PRK11623 454 prRRTRRPRKRAPRRE 469
|
|
| PcnB |
COG0617 |
tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and ... |
15-369 |
4.59e-78 |
|
tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; tRNA nucleotidyltransferase/poly(A) polymerase is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 440382 [Multi-domain] Cd Length: 391 Bit Score: 248.96 E-value: 4.59e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 15 QLPAYILDVIDALTKAGYEAYIVGGGVRDLMLGLNPKDFDAVTNATPSQVKEVFGRRCRIIG--RRFELAHVYSGRELVE 92
Cdd:COG0617 1 RLSPNALKVLEALEEAGFEAYLVGGAVRDLLLGRPPKDIDIVTVATPEEVAALFRKALRTVPvgRDFGTVTVVFGGEKIE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 93 VATFRAPPKRAVtsaagmiLRD--NNWG-TIEQDFARRDFSINALYYQPRKGIVLDFCHAVDDIKSKTLRLLGDPTVRFE 169
Cdd:COG0617 81 VATARTERYYGD-------GRRpfVEFGdTLEEDLARRDFTINALAYDLNDGELIDPFGGLADLEARVIRTVGDPEERFR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 170 EDPVRMLRTLRFAAKLNFNIDPAILEIFTpEMTQLLRDVSPHRLYDESQKLFTMGHLNRVLPMLIDFGIWRQLfadikpd 249
Cdd:COG0617 154 EDPLRILRAVRFAARLGFTIEPETLAAIR-EMAGLLDRLSAERVWDELLKLLLSPHPSRGLELLRETGLLEVL------- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 250 itpfielaakntdqriaigktinpAFFYAVLLWKPFLERCDfylSKGVIPAEARAQAGLDVLKRQATRTVIPRFAETFIR 329
Cdd:COG0617 226 ------------------------ALRLAALLHDLGKPATR---EDGLPTFHGHEEAGAELAEALLKRLRLPNRERKLVR 278
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 491324444 330 EVWEMQTRLL---NPKPQQIAALSNHaRFRAGFDFLLLRERSG 369
Cdd:COG0617 279 ELVELHLRFHglgELRDSAVRRLLER-GPEALEDLLLLRENGL 320
|
|
| PolyA_pol |
pfam01743 |
Poly A polymerase head domain; This family includes nucleic acid independent RNA polymerases, ... |
34-159 |
1.18e-30 |
|
Poly A polymerase head domain; This family includes nucleic acid independent RNA polymerases, such as Poly(A) polymerase, which adds the poly (A) tail to mRNA EC:2.7.7.19. This family also includes the tRNA nucleotidyltransferase that adds the CCA to the 3' of the tRNA EC:2.7.7.25. This family is part of the nucleotidyltransferase superfamily.
Pssm-ID: 396348 [Multi-domain] Cd Length: 126 Bit Score: 115.07 E-value: 1.18e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 34 AYIVGGGVRDLMLGLNPKDFDAVTNATPSQVKEVFGRRCRIIGRR---FELAHVYSGRELVEVATFRAP--------PKR 102
Cdd:pfam01743 1 LYIVGGAVRDLLLGKTPKDVDIATDATPEQVATLFRRRRIVHLLSgieFGTIHVIFGNQILEVATFRIEfdesdfrnPRS 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 491324444 103 AVTSaagmilrdnnwGTIEQDFARRDFSINALYYQPRKGIVLDFCHAVDDIKSKTLR 159
Cdd:pfam01743 81 EEYT-----------GTLEEDAKRRDFTINALAYNPNSGEVIDYFGGIKDLKSGVIR 126
|
|
| NT_ClassII-CCAase |
cd05398 |
Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; CCA-adding enzymes add the ... |
17-154 |
2.69e-29 |
|
Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; CCA-adding enzymes add the sequence [cytidine(C)-cytidine-adenosine (A)], one nucleotide at a time, onto the 3' end of tRNA, in a template-independent reaction. This Class II group is comprised mainly of eubacterial and eukaryotic enzymes and includes Bacillus stearothermophilus CCAase, Escherichia coli poly(A) polymerase I, human mitochondrial CCAase, and Saccharomyces cerevisiae CCAase (CCA1). CCA-adding enzymes have a single catalytic pocket, which recognizes both ATP and CTP substrates. Included in this subgroup are CC- and A-adding enzymes from various ancient species of bacteria such as Aquifex aeolicus; these enzymes collaborate to add CCA to tRNAs. This family belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These carboxylate residues are fairly well conserved in this family. Escherichia coli CCAase is related to this group but has not been included in this alignment as this enzyme lacks the N-terminal helix conserved in the remainder of the NT superfamily.
Pssm-ID: 143388 [Multi-domain] Cd Length: 139 Bit Score: 111.92 E-value: 2.69e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 17 PAYILDVIDALTKA-GYEAYIVGGGVRDLMLGLNPKDFDAVTNA-TPSQVKEVFGRRCR---IIGRRFELAHVYSGRELV 91
Cdd:cd05398 1 TPELLKLLRELKKAlGYEAYLVGGAVRDLLLGRPPKDIDIATDAdGPEFAEALFKKIGGrvvGLGEEFGTATVVINGLTI 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491324444 92 EVATFRappKRAVTSAAGMIlrDNNWGTIEQDFARRDFSINALYYQPRKGIVLDFCHAVDDIK 154
Cdd:cd05398 81 DVATLR---TETYTDPGRRP--PVVGFTIEEDLLRRDFTINAMAYDLDDGELIDPFGGLKDLE 138
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| pcnB |
TIGR01942 |
poly(A) polymerase; This model describes the pcnB family of poly(A) polymerases (also known as ... |
6-413 |
1.92e-107 |
|
poly(A) polymerase; This model describes the pcnB family of poly(A) polymerases (also known as plasmid copy number protein). These enzymes sequentially add adenosine nucleotides to the 3' end of RNAs, targeting them for degradation by the cell. This was originally described for anti-sense RNAs, but was later demonstrated for mRNAs as well. Members of this family are as yet limited to the gamma- and beta-proteobacteria, with putative members in the Chlamydiacae and spirochetes. This family has homology to tRNA nucleotidyltransferase (cca).
Pssm-ID: 130997 [Multi-domain] Cd Length: 410 Bit Score: 325.60 E-value: 1.92e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 6 ASKCGLSTTQLPAYILDVIDALTKAGYEAYIVGGGVRDLMLGLNPKDFDAVTNATPSQVKEVFGRRCRIIGRrFELAHVY 85
Cdd:TIGR01942 4 ESEHNIPRQSFSAHALNVVERLKGAGYQAYIVGGAVRDLLLGIEPKDFDVVTSATPEEVRKLFRNSRIVGRR-FRLVHVS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 86 SGRELVEVATFRAPPKRAVtSAAGMILRDNNWGTIEQDFARRDFSINALYYQPRKGIVLDFCHAVDDIKSKTLRLLGDPT 165
Cdd:TIGR01942 83 FGRQIIEVATFRSGHKSSV-NAEGRILKDNVYGTLEEDAWRRDFTVNALYYDPSREVIIDYVGGMEDLKNRRLRLIGDPR 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 166 VRFEEDPVRMLRTLRFAAKLNFNIDPAILEIFTpEMTQLLRDVSPHRLYDESQKLFTMGHLNRVLPMLIDFgiwrQLFAD 245
Cdd:TIGR01942 162 SRYQEDPVRMLRALRFSVKLEFTIDESTARPIR-ESAPLLKGIPPARLFEEILKLLFSGRSAALFRMLCGY----QLLEP 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 246 IKPDITPFIELAAK------------NTDQRIAIGKTINPAFFYAVLLWKPFLERCDFYLSKGVIPAEARAQAGLDVLKR 313
Cdd:TIGR01942 237 LFPSVAYALRESPKfesaftvqalvnDTDFRVKRDKPVTPAFLYAALLWPGLVFRVADAPDQGVMPYPAVFDAIRDFVEE 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 314 QATRTVIPRFAETFIREVWEMQTRLLNPKPQQIAALSNHARFRAGFDFLLLRERSGDAqTQEMGTWWDQYQTmsTDEKER 393
Cdd:TIGR01942 317 QCAPISIPKRFSIPTREIWQMQLRLERRSGMRARKLLGHARFRAAYDLLLLREVCGRE-NAVLGEWWTPYQL--ASEEER 393
|
410 420
....*....|....*....|
gi 491324444 394 aigqynRQRAKSRRKAAQEE 413
Cdd:TIGR01942 394 ------TEMTRSAARHEGNR 407
|
|
| pcnB |
PRK11623 |
poly(A) polymerase I; Provisional |
21-413 |
1.54e-91 |
|
poly(A) polymerase I; Provisional
Pssm-ID: 236939 [Multi-domain] Cd Length: 472 Bit Score: 286.65 E-value: 1.54e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 21 LDVIDALTKAGYEAYIVGGGVRDLMLGLNPKDFDAVTNATPSQVKEVFGRRCRIIGRrFELAHVYSGRELVEVATFRAPP 100
Cdd:PRK11623 56 LKVLYRLNKAGYEAYLVGGGVRDLLLGKKPKDFDVTTNATPEQVRKLFRNCRLVGRR-FRLAHVMFGPEIIEVATFRGHH 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 101 KRAVTSAA-------GMILRDNNWGTIEQDFARRDFSINALYYQPRKGIVLDFCHAVDDIKSKTLRLLGDPTVRFEEDPV 173
Cdd:PRK11623 135 EGNESDRNtsqrgqnGMLLRDNIFGSIEEDAQRRDFTINSLYYSVADFTVRDYVGGMKDLKEGVIRLIGNPETRYREDPV 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 174 RMLRTLRFAAKLNFNIDPAILEIFtPEMTQLLRDVSPHRLYDESQKLFTMGHLNRVLPMLIDFGIWRQLFADIKPDITP- 252
Cdd:PRK11623 215 RMLRAVRFAAKLDMRISPETAEPI-PRLATLLNDIPPARLFEESLKLLQAGYGYETYKLLCEYHLFQPLFPTITRYFTEn 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 253 -------FIELAAKNTDQRIAIGKTINPAFFYAVLLWKPFLERCD-FYLSKGVIPAEARAQAGLDVLKRQATRTVIPRFA 324
Cdd:PRK11623 294 gdspmerIIEQVLKNTDTRIHNDMRVNPAFLFAAMFWYPLLEHAQkIAQESGLAYYDAFALAMNDVLDEACRSLAIPKRL 373
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 325 ETFIREVWEMQTRLLNPKPQQIAALSNHARFRAGFDFLLLR-ERSGDAQTQEMGTWWDQYQTMSTDEKERAIGQYN---- 399
Cdd:PRK11623 374 TTLTRDIWQLQLRMSRRQGKRAWKLMEHPKFRAAYDLLALRaEVENNAELQRLAQWWGEFQVSAPPQQKGMLNELDddpa 453
|
410
....*....|....*.
gi 491324444 400 --RQRAKSRRKAAQEE 413
Cdd:PRK11623 454 prRRTRRPRKRAPRRE 469
|
|
| PcnB |
COG0617 |
tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and ... |
15-369 |
4.59e-78 |
|
tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; tRNA nucleotidyltransferase/poly(A) polymerase is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 440382 [Multi-domain] Cd Length: 391 Bit Score: 248.96 E-value: 4.59e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 15 QLPAYILDVIDALTKAGYEAYIVGGGVRDLMLGLNPKDFDAVTNATPSQVKEVFGRRCRIIG--RRFELAHVYSGRELVE 92
Cdd:COG0617 1 RLSPNALKVLEALEEAGFEAYLVGGAVRDLLLGRPPKDIDIVTVATPEEVAALFRKALRTVPvgRDFGTVTVVFGGEKIE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 93 VATFRAPPKRAVtsaagmiLRD--NNWG-TIEQDFARRDFSINALYYQPRKGIVLDFCHAVDDIKSKTLRLLGDPTVRFE 169
Cdd:COG0617 81 VATARTERYYGD-------GRRpfVEFGdTLEEDLARRDFTINALAYDLNDGELIDPFGGLADLEARVIRTVGDPEERFR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 170 EDPVRMLRTLRFAAKLNFNIDPAILEIFTpEMTQLLRDVSPHRLYDESQKLFTMGHLNRVLPMLIDFGIWRQLfadikpd 249
Cdd:COG0617 154 EDPLRILRAVRFAARLGFTIEPETLAAIR-EMAGLLDRLSAERVWDELLKLLLSPHPSRGLELLRETGLLEVL------- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 250 itpfielaakntdqriaigktinpAFFYAVLLWKPFLERCDfylSKGVIPAEARAQAGLDVLKRQATRTVIPRFAETFIR 329
Cdd:COG0617 226 ------------------------ALRLAALLHDLGKPATR---EDGLPTFHGHEEAGAELAEALLKRLRLPNRERKLVR 278
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 491324444 330 EVWEMQTRLL---NPKPQQIAALSNHaRFRAGFDFLLLRERSG 369
Cdd:COG0617 279 ELVELHLRFHglgELRDSAVRRLLER-GPEALEDLLLLRENGL 320
|
|
| PRK13299 |
PRK13299 |
tRNA CCA-pyrophosphorylase; Provisional |
21-242 |
5.03e-32 |
|
tRNA CCA-pyrophosphorylase; Provisional
Pssm-ID: 237339 [Multi-domain] Cd Length: 394 Bit Score: 126.49 E-value: 5.03e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 21 LDVIDALTKAGYEAYIVGGGVRDLMLGLNPKDFDAVTNATPSQVKEVFGRrcriigrrfelaHVYSGRE----LV----- 91
Cdd:PRK13299 10 LPILEKIKEAGFEAYFVGGSVRDYLLGRPIHDVDIATSAYPEEVKAIFPR------------TVDVGIEhgtvLVlenge 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 92 --EVATFRA---------PPKraVTsaagmILRDnnwgtIEQDFARRDFSINALYYQpRKGIVLDFCHAVDDIKSKTLRL 160
Cdd:PRK13299 78 eyEVTTFRTeseyvdyrrPSE--VT-----FVRS-----LEEDLKRRDFTINAIAMD-ENGEIIDLFDGLEDLKNRLIRA 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 161 LGDPTVRFEEDPVRMLRTLRFAAKLNFNIDPAILEiftpEMTQ---LLRDVSPHRLYDESQKLFTMGHLNRVLPMLIDFG 237
Cdd:PRK13299 145 VGNAEERFQEDALRMMRAVRFASQLGFDLETETFE----AMKTqapLLEKISVERIFVEFEKLLLGPFWRKGLKLLIETG 220
|
....*
gi 491324444 238 IWRQL 242
Cdd:PRK13299 221 LYNYL 225
|
|
| PolyA_pol |
pfam01743 |
Poly A polymerase head domain; This family includes nucleic acid independent RNA polymerases, ... |
34-159 |
1.18e-30 |
|
Poly A polymerase head domain; This family includes nucleic acid independent RNA polymerases, such as Poly(A) polymerase, which adds the poly (A) tail to mRNA EC:2.7.7.19. This family also includes the tRNA nucleotidyltransferase that adds the CCA to the 3' of the tRNA EC:2.7.7.25. This family is part of the nucleotidyltransferase superfamily.
Pssm-ID: 396348 [Multi-domain] Cd Length: 126 Bit Score: 115.07 E-value: 1.18e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 34 AYIVGGGVRDLMLGLNPKDFDAVTNATPSQVKEVFGRRCRIIGRR---FELAHVYSGRELVEVATFRAP--------PKR 102
Cdd:pfam01743 1 LYIVGGAVRDLLLGKTPKDVDIATDATPEQVATLFRRRRIVHLLSgieFGTIHVIFGNQILEVATFRIEfdesdfrnPRS 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 491324444 103 AVTSaagmilrdnnwGTIEQDFARRDFSINALYYQPRKGIVLDFCHAVDDIKSKTLR 159
Cdd:pfam01743 81 EEYT-----------GTLEEDAKRRDFTINALAYNPNSGEVIDYFGGIKDLKSGVIR 126
|
|
| NT_ClassII-CCAase |
cd05398 |
Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; CCA-adding enzymes add the ... |
17-154 |
2.69e-29 |
|
Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; CCA-adding enzymes add the sequence [cytidine(C)-cytidine-adenosine (A)], one nucleotide at a time, onto the 3' end of tRNA, in a template-independent reaction. This Class II group is comprised mainly of eubacterial and eukaryotic enzymes and includes Bacillus stearothermophilus CCAase, Escherichia coli poly(A) polymerase I, human mitochondrial CCAase, and Saccharomyces cerevisiae CCAase (CCA1). CCA-adding enzymes have a single catalytic pocket, which recognizes both ATP and CTP substrates. Included in this subgroup are CC- and A-adding enzymes from various ancient species of bacteria such as Aquifex aeolicus; these enzymes collaborate to add CCA to tRNAs. This family belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These carboxylate residues are fairly well conserved in this family. Escherichia coli CCAase is related to this group but has not been included in this alignment as this enzyme lacks the N-terminal helix conserved in the remainder of the NT superfamily.
Pssm-ID: 143388 [Multi-domain] Cd Length: 139 Bit Score: 111.92 E-value: 2.69e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 17 PAYILDVIDALTKA-GYEAYIVGGGVRDLMLGLNPKDFDAVTNA-TPSQVKEVFGRRCR---IIGRRFELAHVYSGRELV 91
Cdd:cd05398 1 TPELLKLLRELKKAlGYEAYLVGGAVRDLLLGRPPKDIDIATDAdGPEFAEALFKKIGGrvvGLGEEFGTATVVINGLTI 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491324444 92 EVATFRappKRAVTSAAGMIlrDNNWGTIEQDFARRDFSINALYYQPRKGIVLDFCHAVDDIK 154
Cdd:cd05398 81 DVATLR---TETYTDPGRRP--PVVGFTIEEDLLRRDFTINAMAYDLDDGELIDPFGGLKDLE 138
|
|
| PolyA_pol_arg_C |
pfam12626 |
Polymerase A arginine-rich C-terminus; The C-terminus of polymerase A in E coli is ... |
296-408 |
2.86e-29 |
|
Polymerase A arginine-rich C-terminus; The C-terminus of polymerase A in E coli is arginine-rich and is necessary for full functioning of the enzyme.
Pssm-ID: 463647 [Multi-domain] Cd Length: 116 Bit Score: 111.14 E-value: 2.86e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 296 GVIPAEARAQAGLDVLKRQATRTVIPRFAETFIREVWEMQTRLLNPKPQQIAALSNHARFRAGFDFLLLRERSGDAqTQE 375
Cdd:pfam12626 2 GLPPYDALQLAADEVLDEQCQRVAIPRRFTAPMREIWLLQPRLEKRQGKRPFRLLEHPRFRAAYDFLLLRAESGEV-LQE 80
|
90 100 110
....*....|....*....|....*....|...
gi 491324444 376 MGTWWDQYQTMSTDEKERAIGQYNRQRAKSRRK 408
Cdd:pfam12626 81 LAEWWTRFQEADEAEREAMIAELGADAAKKKRR 113
|
|
| PRK13298 |
PRK13298 |
tRNA CCA-pyrophosphorylase; Provisional |
33-221 |
3.86e-17 |
|
tRNA CCA-pyrophosphorylase; Provisional
Pssm-ID: 237338 [Multi-domain] Cd Length: 417 Bit Score: 83.24 E-value: 3.86e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 33 EAYIVGGGVRDLMLGLNPKDFD-AVTNATPsqvKEVFGRRCRIIGRRFEL-AHVYSGRELvevATFRAPPKRAVtSAAGM 110
Cdd:PRK13298 2 KIYLVGGAVRDSLLNLPVKDKDwVVVGGTP---KILLSINFQQVGKDFPVfLHPETHEEY---ALARTERKSGV-GYTGF 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 111 ILRDNNWGTIEQDFARRDFSINALYYQpRKGIVLDFCHAVDDIKsktLRLLGDPTVRFEEDPVRMLRTLRFAAK---LNF 187
Cdd:PRK13298 75 ITDTSSDVTLEEDLIRRDLTINAIAQD-ENGNYIDPFQGKKDIQ---LRLLRHVSESFIEDPLRVLRVARFAALlvhLGF 150
|
170 180 190
....*....|....*....|....*....|....*....
gi 491324444 188 NIDPAILEIftpeMTQL-----LRDVSPHRLYDESQKLF 221
Cdd:PRK13298 151 KIAKETMIL----MCIMvkkheLLYLTPERIWNETEKAL 185
|
|
| PRK13297 |
PRK13297 |
tRNA CCA-pyrophosphorylase; Provisional |
30-246 |
3.76e-16 |
|
tRNA CCA-pyrophosphorylase; Provisional
Pssm-ID: 139469 [Multi-domain] Cd Length: 364 Bit Score: 80.04 E-value: 3.76e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 30 AGYEAYIVGGGVRDLMLGLNPKDFD-AVTNATPSQVKEVFGRRCRIIGRRFelAHVYSGRELVEVATFRappkRAVTSAA 108
Cdd:PRK13297 10 AGLQVYIVGGAVRDALLGLPAGDRDwVVVGATPEDMARRGFIPVGGDFPVF--LHPRTKEEYALARTER----KSGRGYK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 109 GMILRDNNWGTIEQDFARRDFSINALYYQPrKGIVLDFCHAVDDIKSKTLRLLGDPtvrFEEDPVRMLRTLRFAAKL-NF 187
Cdd:PRK13297 84 GFTFYTGADVTLEQDLQRRDLTVNAIARTP-QGELVDPLDGVADVRARVLRHVGEA---FAEDPVRILRLGRFAARFgDF 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491324444 188 NIDPAILEI------------FTP-----EMTQLLRDVSPHRLYDesqKLFTMGHLNRVLPMLIDfgiWRQLFADI 246
Cdd:PRK13297 160 SIAPETMQLcrrmveageadaLVPervwkEVSRGLMAQAPSRMLD---VLARAGALARVMPELHD---DAAVRAEI 229
|
|
| cca |
PRK10885 |
multifunctional CCA addition/repair protein; |
35-246 |
3.43e-13 |
|
multifunctional CCA addition/repair protein;
Pssm-ID: 182810 [Multi-domain] Cd Length: 409 Bit Score: 71.04 E-value: 3.43e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 35 YIVGGGVRDLMLGLNPKDFD-AVTNATPSQVKE-----------VFGrrcriigrrfelaHVYSGRELVEVATFRappkr 102
Cdd:PRK10885 4 YLVGGAVRDALLGLPVKDRDwVVVGATPEEMLAqgyqqvgkdfpVFL-------------HPKTHEEYALARTER----- 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 103 avTSAAGmilrdnnWG----------TIEQDFARRDFSINALYyQPRKGIVLDFCHAVDDIKSKTLRLLGDPtvrFEEDP 172
Cdd:PRK10885 66 --KSGRG-------YTgftcyaapdvTLEEDLIRRDLTINAMA-QDDDGELIDPYGGQRDLEARLLRHVSPA---FAEDP 132
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491324444 173 VRMLRTLRFAAK---LNFNIDPAILEIFTpEMTQL--LRDVSPHRLYDESQKLFTMGHLNRVLPMLIDFGIWRQLFADI 246
Cdd:PRK10885 133 LRVLRVARFAARfahLGFRIAPETLALMR-EMVASgeLDALTPERVWKETERALMERNPQVFFQVLRDCGALAVLLPEI 210
|
|
| PRK13296 |
PRK13296 |
CCA tRNA nucleotidyltransferase; |
33-207 |
4.43e-12 |
|
CCA tRNA nucleotidyltransferase;
Pssm-ID: 106256 [Multi-domain] Cd Length: 360 Bit Score: 67.32 E-value: 4.43e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 33 EAYIVGGGVRDLMLGLNPKDFD-AVTNATPSQ-VKEVFGRRCRIIGrrfelahVYSGRELVEVATFRAPPKRAVTSAAGM 110
Cdd:PRK13296 2 KFYLVGGAVRDMLLGITPKDKDwVVVGATEDEmLANGFIKIAANFP-------VFIHPQTKQEYALARSEKKTASGYHGF 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491324444 111 ILRDNNWGTIEQDFARRDFSINALYYQPRKGIVLDFcHAVDDIKSKTLRllgDPTVRFEEDPVRMLRTLRFAAKL---NF 187
Cdd:PRK13296 75 EVNFSKYITLEDDLKRRDLTINSIAIDQNNKVIDPF-NGQADLQNRILR---HTSIAFIEDPLRVVRLARFKAQLsnfNF 150
|
170 180
....*....|....*....|....*
gi 491324444 188 NIDPAILEIF-----TPEMTQLLRD 207
Cdd:PRK13296 151 SIAQEMLALIkelvkTGELNHLTRE 175
|
|
| PolyA_pol_RNAbd |
pfam12627 |
Probable RNA and SrmB- binding site of polymerase A; This region encompasses much of the RNA ... |
186-254 |
8.18e-09 |
|
Probable RNA and SrmB- binding site of polymerase A; This region encompasses much of the RNA and SrmB binding motifs on polymerase A.
Pssm-ID: 463648 [Multi-domain] Cd Length: 64 Bit Score: 51.72 E-value: 8.18e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491324444 186 NFNIDPAILEIFtPEMTQLLRDVSPHRLYDESQKLFTMGHLNRVLPMLIDFGIWRQLFadikPDITPFI 254
Cdd:pfam12627 1 GFTIEPETREAI-RKLAPLLKKISPERIFEELLKLLLSGHPERGLELLRETGLLEYLF----PELAAAL 64
|
|
| |
