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Conserved domains on  [gi|491320543|ref|WP_005178509|]
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MULTISPECIES: 3-deoxy-8-phosphooctulonate synthase [Acinetobacter]

Protein Classification

3-deoxy-8-phosphooctulonate synthase( domain architecture ID 10012268)

3-deoxy-8-phosphooctulonate synthase catalyzes the condensation reaction between arabinose 5-phosphate and phosphoenolpyruvate to synthesize 3-deoxy-D-manno-octulosonate-8-phosphate (KDO8P), the precursor of the 8-carbon sugar KDO, which is an essential component of gram-negative bacterial lipopolysaccharides

Gene Ontology:  GO:0019294|GO:0008676
SCOP:  4003245

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK05198 PRK05198
2-dehydro-3-deoxyphosphooctonate aldolase; Provisional
 13-276 0e+00

2-dehydro-3-deoxyphosphooctonate aldolase; Provisional


:

Pssm-ID: 235363  Cd Length: 264  Bit Score: 515.02  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543  13 GDIQMANHLPFVLFGGMNVLESKDLAFEIAETYIDICTRLNIPYVFKASFDKANRSSLNSFRGPGLEKGIEWLADIKKHF 92
Cdd:PRK05198   1 GDIEVGNDLPFFLIAGPCVIESRDLALRIAEHLKEITDKLGIPYVFKASFDKANRSSIHSFRGPGLEEGLKILQEVKETF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543  93 NVPIITDVHEPYQAAPVAEVADIIQLPAFLSRQTDLVEAMAKTQAIINIKKAQFLAPHEMRHILHKCLEAGNDKLILCER 172
Cdd:PRK05198  81 GVPVLTDVHEPEQAAPVAEVVDVLQIPAFLCRQTDLLVAAAKTGKVVNIKKGQFLAPWDMKNVVDKVREAGNDKIILCER 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543 173 GSAFGYNNLVVDMLGFDIMKEMNVPVFFDVTHALQTPGGRADSAGGRRAQITTLARAGMATGLAGLFLEAHPDPDVAKCD 252
Cdd:PRK05198 161 GTSFGYNNLVVDMRGLPIMRETGAPVIFDATHSVQLPGGQGGSSGGQREFVPVLARAAVAVGVAGLFIETHPDPDNALSD 240

                        250       260
                 ....*....|....*....|....
gi 491320543 253 GPCALRLSQLEPFLAQLKELDTLV 276
Cdd:PRK05198 241 GPNMLPLDKLEPLLEQLKAIDDLV 264
 
Name Accession Description Interval E-value
PRK05198 PRK05198
2-dehydro-3-deoxyphosphooctonate aldolase; Provisional
 13-276 0e+00

2-dehydro-3-deoxyphosphooctonate aldolase; Provisional


Pssm-ID: 235363  Cd Length: 264  Bit Score: 515.02  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543  13 GDIQMANHLPFVLFGGMNVLESKDLAFEIAETYIDICTRLNIPYVFKASFDKANRSSLNSFRGPGLEKGIEWLADIKKHF 92
Cdd:PRK05198   1 GDIEVGNDLPFFLIAGPCVIESRDLALRIAEHLKEITDKLGIPYVFKASFDKANRSSIHSFRGPGLEEGLKILQEVKETF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543  93 NVPIITDVHEPYQAAPVAEVADIIQLPAFLSRQTDLVEAMAKTQAIINIKKAQFLAPHEMRHILHKCLEAGNDKLILCER 172
Cdd:PRK05198  81 GVPVLTDVHEPEQAAPVAEVVDVLQIPAFLCRQTDLLVAAAKTGKVVNIKKGQFLAPWDMKNVVDKVREAGNDKIILCER 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543 173 GSAFGYNNLVVDMLGFDIMKEMNVPVFFDVTHALQTPGGRADSAGGRRAQITTLARAGMATGLAGLFLEAHPDPDVAKCD 252
Cdd:PRK05198 161 GTSFGYNNLVVDMRGLPIMRETGAPVIFDATHSVQLPGGQGGSSGGQREFVPVLARAAVAVGVAGLFIETHPDPDNALSD 240

                        250       260
                 ....*....|....*....|....
gi 491320543 253 GPCALRLSQLEPFLAQLKELDTLV 276
Cdd:PRK05198 241 GPNMLPLDKLEPLLEQLKAIDDLV 264
KdsA COG2877
3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell wall/membrane/envelope ...
 12-276 0e+00

3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell wall/membrane/envelope biogenesis]; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase is part of the Pathway/BioSystem: Lipid A biosynthesis


Pssm-ID: 442124  Cd Length: 265  Bit Score: 504.57  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543  12 LGDIQMANHLPFVLFGGMNVLESKDLAFEIAETYIDICTRLNIPYVFKASFDKANRSSLNSFRGPGLEKGIEWLADIKKH 91
Cdd:COG2877    1 IGGIEVGNDKPLFLIAGPCVIESEDLALEIAEKLKEITDKLGIPYIFKASFDKANRSSIDSFRGPGLEEGLKILAEVKEE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543  92 FNVPIITDVHEPYQAAPVAEVADIIQLPAFLSRQTDLVEAMAKTQAIINIKKAQFLAPHEMRHILHKCLEAGNDKLILCE 171
Cdd:COG2877   81 FGVPVLTDVHEPEQAAPVAEVVDVLQIPAFLCRQTDLLVAAAKTGKVVNVKKGQFLAPWDMKNVVEKVREAGNDNILLTE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543 172 RGSAFGYNNLVVDMLGFDIMKEMNVPVFFDVTHALQTPGGRADSAGGRRAQITTLARAGMATGLAGLFLEAHPDPDVAKC 251
Cdd:COG2877  161 RGTSFGYNNLVVDMRSLPIMRETGYPVVFDATHSVQLPGGQGGSSGGQREFVPVLARAAVAVGVDGLFMETHPDPDKALS 240

                        250       260
                 ....*....|....*....|....*
gi 491320543 252 DGPCALRLSQLEPFLAQLKELDTLV 276
Cdd:COG2877  241 DGPNMLPLDKLEELLEQLKAIDELV 265
KDO8P_synth TIGR01362
3-deoxy-8-phosphooctulonate synthase; This model describes 3-deoxy-8-phosphooctulonate ...
 22-278 1.55e-147

3-deoxy-8-phosphooctulonate synthase; This model describes 3-deoxy-8-phosphooctulonate synthase. Alternate names include 2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-d-manno-octulosonic acid 8-phosphate and KDO-8 phosphate synthetase. It catalyzes the aldol condensation of phosphoenolpyruvate with D-arabinose 5-phosphate: phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate In Gram-negative bacteria, this is the first step in the biosynthesis of 3-deoxy-D-manno-octulosonate, part of the oligosaccharide core of lipopolysaccharide. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]


Pssm-ID: 130429  Cd Length: 258  Bit Score: 413.68  E-value: 1.55e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543   22 PFVLFGGMNVLESKDLAFEIAETYIDICTRLNIPYVFKASFDKANRSSLNSFRGPGLEKGIEWLADIKKHFNVPIITDVH 101
Cdd:TIGR01362   2 KFFLIAGPCVIESEDHALRVAEKLKELTSKLGVPFIFKSSFDKANRSSIHSFRGPGLEEGLKILQKVKEEFGVPILTDVH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543  102 EPYQAAPVAEVADIIQLPAFLSRQTDLVEAMAKTQAIINIKKAQFLAPHEMRHILHKCLEAGNDKLILCERGSAFGYNNL 181
Cdd:TIGR01362  82 ESSQCEPVAEVVDIIQIPAFLCRQTDLLVAAAKTGRIVNVKKGQFLSPWDMKNVVEKVLSTGNKNILLCERGTSFGYNNL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543  182 VVDMLGFDIMKEMNVPVFFDVTHALQTPGGRADSAGGRRAQITTLARAGMATGLAGLFLEAHPDPDVAKCDGPCALRLSQ 261
Cdd:TIGR01362 162 VVDMRSLPIMRELGCPVIFDATHSVQQPGGLGGASGGLREFVPTLARAAVAVGIDGLFMETHPDPKNAKSDGPNMLPLSE 241

                         250
                  ....*....|....*..
gi 491320543  262 LEPFLAQLKELDTLVKG 278
Cdd:TIGR01362 242 LEGLLEKLLAIDALTKS 258
DAHP_synth_1 pfam00793
DAHP synthetase I family; Members of this family catalyze the first step in aromatic amino ...
 13-277 1.48e-89

DAHP synthetase I family; Members of this family catalyze the first step in aromatic amino acid biosynthesis from chorismate. E-coli has three related synthetases, which are inhibited by different aromatic amino acids. This family also includes KDSA which has very similar catalytic activity but is involved in the first step of liposaccharide biosynthesis. The enzyme is also part of the shikimate pathway, EC:2.5.1.54.


Pssm-ID: 395641  Cd Length: 271  Bit Score: 267.26  E-value: 1.48e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543   13 GDIQMANHLPFVLFGGMNVLESKDLAFEIAETYIDICTRLNIPYVFKASFDKANRSSlNSFRGPGLEKGIEWLADIKKHF 92
Cdd:pfam00793   8 QDIIIGKDDRLLVIAGPCSIEDPEAAMEYARRLKKLGAKLKLIIIMRAYFEKPRTSP-VGFKGLGNDPDLNILFRIKDGL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543   93 NVPIITDVHEPYQAAPVAEVADIIQLPAFLSRQTDLVEAMAKTQAIINIKKAQFLAPHEMRHILHKCLEAG-NDKLILCE 171
Cdd:pfam00793  87 GLPIATEVLDPIDPQYLADVVDIGQIGARTTESQDLLELAGGLSKPVGFKNGTDAAIDEMLAAAEYHLFLGvTKGNILCE 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543  172 RGSAFGY--NNLVVDMLGFDIMKEMNV--PVFFDVTHALQTPGgradsaGGRRAQITTLARAGMATGLAGLFLEAHPDPD 247
Cdd:pfam00793 167 RGIRGGEgpNRNTLDVSAVAILKEETGhlPVMVDVSHANGRKD------GGRQPLVLPLAKAAIAVGIDGLMIEVHPNPG 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 491320543  248 VAKCDGPCALRLSQLEPFLAQLKELDTLVK 277
Cdd:pfam00793 241 NALSDGPQQLKYGKSETDACILWELTELLL 270
BagF_FevY NF041229
phospho-2-dehydro-3-deoxyheptonate aldolase BagF/FevY;
67-270 1.98e-22

phospho-2-dehydro-3-deoxyheptonate aldolase BagF/FevY;


Pssm-ID: 469132 [Multi-domain]  Cd Length: 340  Bit Score: 95.10  E-value: 1.98e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543  67 RSSLNSFRGPGlEKGIEWLADIKKHFNVPIITDVHEPYQAAPVAEVADIIQLPAFLSRQTDLVEAMAKTQAIINIKKAQF 146
Cdd:NF041229 129 RTSPYAFQGLG-EAGLKILADVRAETGLPIVTEVVDAHDVELVASYADMLQIGTRNAQNFALLQAVGDVGKPVMLKRGMS 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543 147 LAPHEMRHILHKCLEAGNDKLILCERG----SAFGYNNLvvDMLGFDIMKEMN-VPVFFDVTHAlqtpggradsaGGRRA 221
Cdd:NF041229 208 GTIEEWLMAAEYVAQRGNLDIVLCERGirtfETATRNTL--DIAAVPIVQRLShLPVIVDPSHS-----------GGRRD 274

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 491320543 222 QITTLARAGMATGLAGLFLEAHPDPDVAKCDGPCALRLSQLEPFLAQLK 270
Cdd:NF041229 275 LVLPLTRAALAVGADGVIVDVHPDPRTALCDGPQALVHEDLEELGAVMR 323
 
Name Accession Description Interval E-value
PRK05198 PRK05198
2-dehydro-3-deoxyphosphooctonate aldolase; Provisional
 13-276 0e+00

2-dehydro-3-deoxyphosphooctonate aldolase; Provisional


Pssm-ID: 235363  Cd Length: 264  Bit Score: 515.02  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543  13 GDIQMANHLPFVLFGGMNVLESKDLAFEIAETYIDICTRLNIPYVFKASFDKANRSSLNSFRGPGLEKGIEWLADIKKHF 92
Cdd:PRK05198   1 GDIEVGNDLPFFLIAGPCVIESRDLALRIAEHLKEITDKLGIPYVFKASFDKANRSSIHSFRGPGLEEGLKILQEVKETF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543  93 NVPIITDVHEPYQAAPVAEVADIIQLPAFLSRQTDLVEAMAKTQAIINIKKAQFLAPHEMRHILHKCLEAGNDKLILCER 172
Cdd:PRK05198  81 GVPVLTDVHEPEQAAPVAEVVDVLQIPAFLCRQTDLLVAAAKTGKVVNIKKGQFLAPWDMKNVVDKVREAGNDKIILCER 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543 173 GSAFGYNNLVVDMLGFDIMKEMNVPVFFDVTHALQTPGGRADSAGGRRAQITTLARAGMATGLAGLFLEAHPDPDVAKCD 252
Cdd:PRK05198 161 GTSFGYNNLVVDMRGLPIMRETGAPVIFDATHSVQLPGGQGGSSGGQREFVPVLARAAVAVGVAGLFIETHPDPDNALSD 240

                        250       260
                 ....*....|....*....|....
gi 491320543 253 GPCALRLSQLEPFLAQLKELDTLV 276
Cdd:PRK05198 241 GPNMLPLDKLEPLLEQLKAIDDLV 264
KdsA COG2877
3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell wall/membrane/envelope ...
 12-276 0e+00

3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell wall/membrane/envelope biogenesis]; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase is part of the Pathway/BioSystem: Lipid A biosynthesis


Pssm-ID: 442124  Cd Length: 265  Bit Score: 504.57  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543  12 LGDIQMANHLPFVLFGGMNVLESKDLAFEIAETYIDICTRLNIPYVFKASFDKANRSSLNSFRGPGLEKGIEWLADIKKH 91
Cdd:COG2877    1 IGGIEVGNDKPLFLIAGPCVIESEDLALEIAEKLKEITDKLGIPYIFKASFDKANRSSIDSFRGPGLEEGLKILAEVKEE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543  92 FNVPIITDVHEPYQAAPVAEVADIIQLPAFLSRQTDLVEAMAKTQAIINIKKAQFLAPHEMRHILHKCLEAGNDKLILCE 171
Cdd:COG2877   81 FGVPVLTDVHEPEQAAPVAEVVDVLQIPAFLCRQTDLLVAAAKTGKVVNVKKGQFLAPWDMKNVVEKVREAGNDNILLTE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543 172 RGSAFGYNNLVVDMLGFDIMKEMNVPVFFDVTHALQTPGGRADSAGGRRAQITTLARAGMATGLAGLFLEAHPDPDVAKC 251
Cdd:COG2877  161 RGTSFGYNNLVVDMRSLPIMRETGYPVVFDATHSVQLPGGQGGSSGGQREFVPVLARAAVAVGVDGLFMETHPDPDKALS 240

                        250       260
                 ....*....|....*....|....*
gi 491320543 252 DGPCALRLSQLEPFLAQLKELDTLV 276
Cdd:COG2877  241 DGPNMLPLDKLEELLEQLKAIDELV 265
PRK12457 PRK12457
3-deoxy-8-phosphooctulonate synthase;
9-283 1.04e-157

3-deoxy-8-phosphooctulonate synthase;


Pssm-ID: 237105  Cd Length: 281  Bit Score: 440.34  E-value: 1.04e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543   9 VVRLGDIQMANHLPFVLFGGMNVLESKDLAFEIAETYIDICTRLNIPYVFKASFDKANRSSLNSFRGPGLEKGIEWLADI 88
Cdd:PRK12457   3 VAISPGITVGNDLPFVLFGGINVLESLDFTLDVCGEYVEVTRKLGIPFVFKASFDKANRSSIHSYRGVGLDEGLRIFEEV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543  89 KKHFNVPIITDVHEPYQAAPVAEVADIIQLPAFLSRQTDLVEAMAKTQAIINIKKAQFLAPHEMRHILHKCLEAGNDKLI 168
Cdd:PRK12457  83 KARFGVPVITDVHEVEQAAPVAEVADVLQVPAFLARQTDLVVAIAKTGKPVNIKKPQFMSPTQMKHVVSKCREAGNDRVI 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543 169 LCERGSAFGYNNLVVDMLGFDIMKEM--NVPVFFDVTHALQT--PGGRAdsAGGRRAQITTLARAGMATGLAGLFLEAHP 244
Cdd:PRK12457 163 LCERGSSFGYDNLVVDMLGFRQMKRTtgDLPVIFDVTHSLQCrdPLGAA--SGGRRRQVLDLARAGMAVGLAGLFLEAHP 240

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 491320543 245 DPDVAKCDGPCALRLSQLEPFLAQLKELDTLVKGFKKLD 283
Cdd:PRK12457 241 DPDRARCDGPSALPLDQLEPFLSQVKALDDLVKSFPPLD 279
KDO8P_synth TIGR01362
3-deoxy-8-phosphooctulonate synthase; This model describes 3-deoxy-8-phosphooctulonate ...
 22-278 1.55e-147

3-deoxy-8-phosphooctulonate synthase; This model describes 3-deoxy-8-phosphooctulonate synthase. Alternate names include 2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-d-manno-octulosonic acid 8-phosphate and KDO-8 phosphate synthetase. It catalyzes the aldol condensation of phosphoenolpyruvate with D-arabinose 5-phosphate: phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate In Gram-negative bacteria, this is the first step in the biosynthesis of 3-deoxy-D-manno-octulosonate, part of the oligosaccharide core of lipopolysaccharide. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]


Pssm-ID: 130429  Cd Length: 258  Bit Score: 413.68  E-value: 1.55e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543   22 PFVLFGGMNVLESKDLAFEIAETYIDICTRLNIPYVFKASFDKANRSSLNSFRGPGLEKGIEWLADIKKHFNVPIITDVH 101
Cdd:TIGR01362   2 KFFLIAGPCVIESEDHALRVAEKLKELTSKLGVPFIFKSSFDKANRSSIHSFRGPGLEEGLKILQKVKEEFGVPILTDVH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543  102 EPYQAAPVAEVADIIQLPAFLSRQTDLVEAMAKTQAIINIKKAQFLAPHEMRHILHKCLEAGNDKLILCERGSAFGYNNL 181
Cdd:TIGR01362  82 ESSQCEPVAEVVDIIQIPAFLCRQTDLLVAAAKTGRIVNVKKGQFLSPWDMKNVVEKVLSTGNKNILLCERGTSFGYNNL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543  182 VVDMLGFDIMKEMNVPVFFDVTHALQTPGGRADSAGGRRAQITTLARAGMATGLAGLFLEAHPDPDVAKCDGPCALRLSQ 261
Cdd:TIGR01362 162 VVDMRSLPIMRELGCPVIFDATHSVQQPGGLGGASGGLREFVPTLARAAVAVGIDGLFMETHPDPKNAKSDGPNMLPLSE 241

                         250
                  ....*....|....*..
gi 491320543  262 LEPFLAQLKELDTLVKG 278
Cdd:TIGR01362 242 LEGLLEKLLAIDALTKS 258
PLN03033 PLN03033
2-dehydro-3-deoxyphosphooctonate aldolase; Provisional
 22-282 2.59e-94

2-dehydro-3-deoxyphosphooctonate aldolase; Provisional


Pssm-ID: 178601  Cd Length: 290  Bit Score: 280.21  E-value: 2.59e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543  22 PFVLFGGMNVLESKDLAFEIAETYIDICTRLNIPYVFKASFDKANRSSLNSFRGPGLEKGIEWLADIKKHFNVPIITDVH 101
Cdd:PLN03033  16 PFFLLAGPNVIESEEHILRMAKHIKDISTKLGLPLVFKSSFDKANRTSSKSFRGPGMAEGLKILEKVKVAYDLPIVTDVH 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543 102 EPYQAAPVAEVADIIQLPAFLSRQTDLVEAMAKTQAIINIKKAQFLAPHEMRHILHKCLEAGNDKLILCERGSAFGYNNL 181
Cdd:PLN03033  96 ESSQCEAVGKVADIIQIPAFLCRQTDLLVAAAKTGKIINIKKGQFCAPSVMRNSAEKVRLAGNPNVMVCERGTMFGYNDL 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543 182 VVDMLGFDIMKEMNVPVFFDVTHALQTPGGRAD-----SAGGRRAQITTLARAGMATGLAGLFLEAHPDPDVAKCDGPCA 256
Cdd:PLN03033 176 IVDPRNLEWMREANCPVVADITHSLQQPAGKKLdgggvASGGLRELIPCIARTAVAVGVDGIFMEVHDDPLSAPVDGPTQ 255

                        250       260
                 ....*....|....*....|....*.
gi 491320543 257 LRLSQLEPFLAQLKELDTLVKGFKKL 282
Cdd:PLN03033 256 WPLRHLEELLEELIAIARVTKGKQRF 281
DAHP_synth_1 pfam00793
DAHP synthetase I family; Members of this family catalyze the first step in aromatic amino ...
 13-277 1.48e-89

DAHP synthetase I family; Members of this family catalyze the first step in aromatic amino acid biosynthesis from chorismate. E-coli has three related synthetases, which are inhibited by different aromatic amino acids. This family also includes KDSA which has very similar catalytic activity but is involved in the first step of liposaccharide biosynthesis. The enzyme is also part of the shikimate pathway, EC:2.5.1.54.


Pssm-ID: 395641  Cd Length: 271  Bit Score: 267.26  E-value: 1.48e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543   13 GDIQMANHLPFVLFGGMNVLESKDLAFEIAETYIDICTRLNIPYVFKASFDKANRSSlNSFRGPGLEKGIEWLADIKKHF 92
Cdd:pfam00793   8 QDIIIGKDDRLLVIAGPCSIEDPEAAMEYARRLKKLGAKLKLIIIMRAYFEKPRTSP-VGFKGLGNDPDLNILFRIKDGL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543   93 NVPIITDVHEPYQAAPVAEVADIIQLPAFLSRQTDLVEAMAKTQAIINIKKAQFLAPHEMRHILHKCLEAG-NDKLILCE 171
Cdd:pfam00793  87 GLPIATEVLDPIDPQYLADVVDIGQIGARTTESQDLLELAGGLSKPVGFKNGTDAAIDEMLAAAEYHLFLGvTKGNILCE 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543  172 RGSAFGY--NNLVVDMLGFDIMKEMNV--PVFFDVTHALQTPGgradsaGGRRAQITTLARAGMATGLAGLFLEAHPDPD 247
Cdd:pfam00793 167 RGIRGGEgpNRNTLDVSAVAILKEETGhlPVMVDVSHANGRKD------GGRQPLVLPLAKAAIAVGIDGLMIEVHPNPG 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 491320543  248 VAKCDGPCALRLSQLEPFLAQLKELDTLVK 277
Cdd:pfam00793 241 NALSDGPQQLKYGKSETDACILWELTELLL 270
AroGA COG2876
3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and ...
 67-272 3.61e-27

3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 442123  Cd Length: 283  Bit Score: 106.69  E-value: 3.61e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543  67 RSSLNSFRGPGlEKGIEWLADIKKHFNVPIITDVHEPYQAAPVAEVADIIQLPAflsR--Q-TDLVEAMAKTQAIINIKK 143
Cdd:COG2876   79 RTSPYSFQGLG-EEGLKLLAEAREETGLPVVTEVMDPRDVELVAEYADILQIGA---RnmQnFELLKEVGRTGKPVLLKR 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543 144 ------AQFLAPHEmrHILhkclEAGNDKLILCERGS-AFG--YNNlVVDMLGFDIMKEM-NVPVFFDVTHAlqtpggra 213
Cdd:COG2876  155 glsatiEEWLMAAE--YIL----SEGNPNVILCERGIrTFEtaTRN-TLDLSAVPVLKELtHLPVIVDPSHA-------- 219

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 491320543 214 dsaGGRRAQITTLARAGMATGLAGLFLEAHPDPDVAKCDGPCALRLSQLEPFLAQLKEL 272
Cdd:COG2876  220 ---TGRRDLVPPMAKAAVAAGADGLMIEVHPDPEKALSDGPQSLTPEEFAELMEELRKL 275
PRK08673 PRK08673
3-deoxy-7-phosphoheptulonate synthase; Reviewed
 67-277 1.83e-26

3-deoxy-7-phosphoheptulonate synthase; Reviewed


Pssm-ID: 181535 [Multi-domain]  Cd Length: 335  Bit Score: 105.74  E-value: 1.83e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543  67 RSSLNSFRGPGlEKGIEWLADIKKHFNVPIITDVHEPYQAAPVAEVADIIQLPAFLSRQTDLVEAMAKTQAIINIKKA-- 144
Cdd:PRK08673 132 RTSPYSFQGLG-EEGLKLLAEAREETGLPIVTEVMDPRDVELVAEYVDILQIGARNMQNFDLLKEVGKTNKPVLLKRGms 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543 145 ----QFLAPHEmrHILHkcleAGNDKLILCERG----SAFGYNNLvvDMLGFDIMKEM-NVPVFFDVTHAlqtpggrads 215
Cdd:PRK08673 211 atieEWLMAAE--YILA----EGNPNVILCERGirtfETATRNTL--DLSAVPVIKKLtHLPVIVDPSHA---------- 272

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491320543 216 aGGRRAQITTLARAGMATGLAGLFLEAHPDPDVAKCDGPCALRLSQLEPFLAQLKELDTLVK 277
Cdd:PRK08673 273 -TGKRDLVEPLALAAVAAGADGLIVEVHPDPEKALSDGPQSLTPEEFEELMKKLRAIAEALG 333
BagF_FevY NF041229
phospho-2-dehydro-3-deoxyheptonate aldolase BagF/FevY;
67-270 1.98e-22

phospho-2-dehydro-3-deoxyheptonate aldolase BagF/FevY;


Pssm-ID: 469132 [Multi-domain]  Cd Length: 340  Bit Score: 95.10  E-value: 1.98e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543  67 RSSLNSFRGPGlEKGIEWLADIKKHFNVPIITDVHEPYQAAPVAEVADIIQLPAFLSRQTDLVEAMAKTQAIINIKKAQF 146
Cdd:NF041229 129 RTSPYAFQGLG-EAGLKILADVRAETGLPIVTEVVDAHDVELVASYADMLQIGTRNAQNFALLQAVGDVGKPVMLKRGMS 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543 147 LAPHEMRHILHKCLEAGNDKLILCERG----SAFGYNNLvvDMLGFDIMKEMN-VPVFFDVTHAlqtpggradsaGGRRA 221
Cdd:NF041229 208 GTIEEWLMAAEYVAQRGNLDIVLCERGirtfETATRNTL--DIAAVPIVQRLShLPVIVDPSHS-----------GGRRD 274

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 491320543 222 QITTLARAGMATGLAGLFLEAHPDPDVAKCDGPCALRLSQLEPFLAQLK 270
Cdd:NF041229 275 LVLPLTRAALAVGADGVIVDVHPDPRTALCDGPQALVHEDLEELGAVMR 323
PRK12595 PRK12595
bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed
 67-272 5.62e-20

bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed


Pssm-ID: 183614 [Multi-domain]  Cd Length: 360  Bit Score: 88.11  E-value: 5.62e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543  67 RSSLNSFRGPGLEkGIEWLADIKKHFNVPIITDVHEPYQAAPVAEVADIIQLPAFLSRQTDLVEAMAKTQAIINIKKA-- 144
Cdd:PRK12595 157 RTSPYDFQGLGVE-GLKILKQVADEYGLAVISEIVNPADVEVALDYVDVIQIGARNMQNFELLKAAGRVNKPVLLKRGls 235

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543 145 ----QFLAPHEmrHILHKcleaGNDKLILCERG----SAFGYNNLvvDMLGFDIMK-EMNVPVFFDVTHALqtpggrads 215
Cdd:PRK12595 236 atieEFIYAAE--YIMSQ----GNGQIILCERGirtyEKATRNTL--DISAVPILKqETHLPVMVDVTHST--------- 298

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 491320543 216 agGRRAQITTLARAGMATGLAGLFLEAHPDPDVAKCDGPCALRLSQLEPFLAQLKEL 272
Cdd:PRK12595 299 --GRRDLLLPTAKAALAIGADGVMAEVHPDPAVALSDSAQQMDIPEFDRFLDELKPL 353
PRK13396 PRK13396
3-deoxy-7-phosphoheptulonate synthase; Provisional
 67-277 3.78e-12

3-deoxy-7-phosphoheptulonate synthase; Provisional


Pssm-ID: 237376 [Multi-domain]  Cd Length: 352  Bit Score: 65.55  E-value: 3.78e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543  67 RSSLNSFRGPGlEKGIEWLADIKKHFNVPIITDVHEPYQAAPVAEVADIIQLPAFLSRQTDLVEAMAKTQAIINIKKAQF 146
Cdd:PRK13396 140 RTSPYAFQGHG-ESALELLAAAREATGLGIITEVMDAADLEKIAEVADVIQVGARNMQNFSLLKKVGAQDKPVLLKRGMA 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320543 147 LAPHEMRHILHKCLEAGNDKLILCERG-----SAFGYNNLvvDMLGFDIMKEM-NVPVFFDVTHALqtpggradsagGRR 220
Cdd:PRK13396 219 ATIDEWLMAAEYILAAGNPNVILCERGirtfdRQYTRNTL--DLSVIPVLRSLtHLPIMIDPSHGT-----------GKS 285

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 491320543 221 AQITTLARAGMATGLAGLFLEAHPDPDVAKCDGPCALRLSQLEPFLAQLKELDTLVK 277
Cdd:PRK13396 286 EYVPSMAMAAIAAGTDSLMIEVHPNPAKALSDGPQSLTPDRFDRLMQELAVIGKTVG 342
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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