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MULTISPECIES: glycine cleavage system protein GcvH [Acinetobacter]

Protein Classification

glycine cleavage system protein H( domain architecture ID 10785558)

glycine cleavage system protein H plays a role in the degradation of glycine by shuttling the methylamine group of glycine from P-protein (glycine dehydrogenase) to the T-protein (aminomethyltransferase).

EC:  1.4.1.27
Gene Ontology:  GO:0019464|GO:0009249|GO:0005960
PubMed:  20375021|18941301

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GcvH COG0509
Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; ...
 1-122 2.69e-69

Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; Glycine cleavage system protein H (lipoate-binding) is part of the Pathway/BioSystem: Glycine cleavage


:

Pssm-ID: 440275  Cd Length: 128  Bit Score: 203.82  E-value: 2.69e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320209   1 MNHPSELKYARTHEWVRIEGDLVVT-GISDHAQDALGDLVYVEAPEVGQQVTAGEQAGVVESVKTASDIHAPVSGTVVEI 79
Cdd:COG0509    1 MEIPDDLKYTEDHEWVRVEGDGTATvGITDFAQDLLGDIVFVELPEVGTEVEAGEPFGVVESVKAVSDLYAPVSGEVVEV 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 491320209  80 NPALEDDPDFVNDEPYGKGWIYKIKPDNLADVEKLLSSSEYEA 122
Cdd:COG0509   81 NEALEDDPELVNEDPYGEGWLFKIKPSDPAELDDLLDAEAYAA 123
 
Name Accession Description Interval E-value
GcvH COG0509
Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; ...
 1-122 2.69e-69

Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; Glycine cleavage system protein H (lipoate-binding) is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440275  Cd Length: 128  Bit Score: 203.82  E-value: 2.69e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320209   1 MNHPSELKYARTHEWVRIEGDLVVT-GISDHAQDALGDLVYVEAPEVGQQVTAGEQAGVVESVKTASDIHAPVSGTVVEI 79
Cdd:COG0509    1 MEIPDDLKYTEDHEWVRVEGDGTATvGITDFAQDLLGDIVFVELPEVGTEVEAGEPFGVVESVKAVSDLYAPVSGEVVEV 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 491320209  80 NPALEDDPDFVNDEPYGKGWIYKIKPDNLADVEKLLSSSEYEA 122
Cdd:COG0509   81 NEALEDDPELVNEDPYGEGWLFKIKPSDPAELDDLLDAEAYAA 123
PRK01202 PRK01202
glycine cleavage system protein GcvH;
1-122 2.77e-68

glycine cleavage system protein GcvH;


Pssm-ID: 234918  Cd Length: 127  Bit Score: 201.16  E-value: 2.77e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320209   1 MNHPSELKYARTHEWVRIEGDLVVTGISDHAQDALGDLVYVEAPEVGQQVTAGEQAGVVESVKTASDIHAPVSGTVVEIN 80
Cdd:PRK01202   2 MNIPADLKYTKSHEWVRVEGDTATVGITDHAQEQLGDIVFVELPEVGDEVKAGETFGVVESVKAASDIYAPVSGEVVEVN 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 491320209  81 PALEDDPDFVNDEPYGKGWIYKIKPDNLADVEKLLSSSEYEA 122
Cdd:PRK01202  82 EALEDSPELVNEDPYGEGWLFKIKPSDESELDDLLDAEAYEA 123
gcvH TIGR00527
glycine cleavage system H protein; This model represents the glycine cleavage system H protein, ...
 2-124 2.10e-50

glycine cleavage system H protein; This model represents the glycine cleavage system H protein, which shuttles the methylamine group of glycine from the P protein to the T protein. The mature protein is about 130 residues long and contains a lipoyl group covalently bound to a conserved Lys residue. The genome of Aquifex aeolicus contains one protein scoring above the trusted cutoff and clustering with other bacterial H proteins, and four more proteins clustering together and scoring below the trusted cutoff; it seems doubtful that all of these homologs are authentic H protein. The Chlamydial homolog of H protein is nearly as divergent as the Aquifex outgroup, is not accompanied by P and T proteins, is not included in the seed alignment, and consequently also scores below the trusted cutoff. [Energy metabolism, Amino acids and amines]


Pssm-ID: 200024  Cd Length: 128  Bit Score: 156.15  E-value: 2.10e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320209    2 NHPSELKYARTHEWVRIEGDLVVT-GISDHAQDALGDLVYVEAPEVGQQVTAGEQAGVVESVKTASDIHAPVSGTVVEIN 80
Cdd:TIGR00527   1 QGPQDLRYSSEHEWVRVEGDKTATvGITKFAQDELGDIVFVELPEVGAEVAAGESLGSVESVKAASDIYAPVDGTVVEVN 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 491320209   81 PALEDDPDFVNDEPYGKGWIYKIKPDNLAD-VEKLLSSSEYEAGL 124
Cdd:TIGR00527  81 TALEDSPELVNEDPYGDGWLIKVKLSDGESeVEGLMSAEQYEATL 125
GCV_H pfam01597
Glycine cleavage H-protein; This is a family of glycine cleavage H-proteins, part of the ...
 7-122 3.44e-50

Glycine cleavage H-protein; This is a family of glycine cleavage H-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. A lipoyl group is attached to a completely conserved lysine residue. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.


Pssm-ID: 396258  Cd Length: 122  Bit Score: 155.57  E-value: 3.44e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320209    7 LKYARTHEWVRIEGDLVVT-GISDHAQDALGDLVYVEAPEVGQQVTAGEQAGVVESVKTASDIHAPVSGTVVEINPALED 85
Cdd:pfam01597   1 LYYTKEHEWVKVEGDGTATvGITDFAQAQLGDIVFVELPEVGTKVKKGESLAAIESVKAASPIYAPVSGEVVEVNEKLED 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 491320209   86 DPDFVNDEPYGKGWIYKIKPDNLADVEKLLSSSEYEA 122
Cdd:pfam01597  81 NPGLINKDPYEDGWIAKLKPSNLEELESLMTAEQYEK 117
GCS_H cd06848
Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage ...
 9-103 6.80e-47

Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-proteins) which catalyzes the oxidative cleavage of glycine. The H-protein shuttles the methylamine group of glycine from the P-protein (glycine dehydrogenase) to the T-protein (aminomethyltransferase) via a lipoyl group, attached to a completely conserved lysine residue.


Pssm-ID: 133457 [Multi-domain]  Cd Length: 96  Bit Score: 146.14  E-value: 6.80e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320209   9 YARTHEWVRIEGDLVVT-GISDHAQDALGDLVYVEAPEVGQQVTAGEQAGVVESVKTASDIHAPVSGTVVEINPALEDDP 87
Cdd:cd06848    1 YTKDHEWVKVEGDGIATvGITDYAQDLLGDIVFVELPEVGTEVKKGDPFGSVESVKAASDLYSPVSGEVVEVNEALLDNP 80

                         90
                 ....*....|....*.
gi 491320209  88 DFVNDEPYGKGWIYKI 103
Cdd:cd06848   81 ELINSDPYGEGWLVKI 96
 
Name Accession Description Interval E-value
GcvH COG0509
Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; ...
 1-122 2.69e-69

Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; Glycine cleavage system protein H (lipoate-binding) is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440275  Cd Length: 128  Bit Score: 203.82  E-value: 2.69e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320209   1 MNHPSELKYARTHEWVRIEGDLVVT-GISDHAQDALGDLVYVEAPEVGQQVTAGEQAGVVESVKTASDIHAPVSGTVVEI 79
Cdd:COG0509    1 MEIPDDLKYTEDHEWVRVEGDGTATvGITDFAQDLLGDIVFVELPEVGTEVEAGEPFGVVESVKAVSDLYAPVSGEVVEV 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 491320209  80 NPALEDDPDFVNDEPYGKGWIYKIKPDNLADVEKLLSSSEYEA 122
Cdd:COG0509   81 NEALEDDPELVNEDPYGEGWLFKIKPSDPAELDDLLDAEAYAA 123
PRK01202 PRK01202
glycine cleavage system protein GcvH;
1-122 2.77e-68

glycine cleavage system protein GcvH;


Pssm-ID: 234918  Cd Length: 127  Bit Score: 201.16  E-value: 2.77e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320209   1 MNHPSELKYARTHEWVRIEGDLVVTGISDHAQDALGDLVYVEAPEVGQQVTAGEQAGVVESVKTASDIHAPVSGTVVEIN 80
Cdd:PRK01202   2 MNIPADLKYTKSHEWVRVEGDTATVGITDHAQEQLGDIVFVELPEVGDEVKAGETFGVVESVKAASDIYAPVSGEVVEVN 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 491320209  81 PALEDDPDFVNDEPYGKGWIYKIKPDNLADVEKLLSSSEYEA 122
Cdd:PRK01202  82 EALEDSPELVNEDPYGEGWLFKIKPSDESELDDLLDAEAYEA 123
gcvH TIGR00527
glycine cleavage system H protein; This model represents the glycine cleavage system H protein, ...
 2-124 2.10e-50

glycine cleavage system H protein; This model represents the glycine cleavage system H protein, which shuttles the methylamine group of glycine from the P protein to the T protein. The mature protein is about 130 residues long and contains a lipoyl group covalently bound to a conserved Lys residue. The genome of Aquifex aeolicus contains one protein scoring above the trusted cutoff and clustering with other bacterial H proteins, and four more proteins clustering together and scoring below the trusted cutoff; it seems doubtful that all of these homologs are authentic H protein. The Chlamydial homolog of H protein is nearly as divergent as the Aquifex outgroup, is not accompanied by P and T proteins, is not included in the seed alignment, and consequently also scores below the trusted cutoff. [Energy metabolism, Amino acids and amines]


Pssm-ID: 200024  Cd Length: 128  Bit Score: 156.15  E-value: 2.10e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320209    2 NHPSELKYARTHEWVRIEGDLVVT-GISDHAQDALGDLVYVEAPEVGQQVTAGEQAGVVESVKTASDIHAPVSGTVVEIN 80
Cdd:TIGR00527   1 QGPQDLRYSSEHEWVRVEGDKTATvGITKFAQDELGDIVFVELPEVGAEVAAGESLGSVESVKAASDIYAPVDGTVVEVN 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 491320209   81 PALEDDPDFVNDEPYGKGWIYKIKPDNLAD-VEKLLSSSEYEAGL 124
Cdd:TIGR00527  81 TALEDSPELVNEDPYGDGWLIKVKLSDGESeVEGLMSAEQYEATL 125
GCV_H pfam01597
Glycine cleavage H-protein; This is a family of glycine cleavage H-proteins, part of the ...
 7-122 3.44e-50

Glycine cleavage H-protein; This is a family of glycine cleavage H-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. A lipoyl group is attached to a completely conserved lysine residue. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.


Pssm-ID: 396258  Cd Length: 122  Bit Score: 155.57  E-value: 3.44e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320209    7 LKYARTHEWVRIEGDLVVT-GISDHAQDALGDLVYVEAPEVGQQVTAGEQAGVVESVKTASDIHAPVSGTVVEINPALED 85
Cdd:pfam01597   1 LYYTKEHEWVKVEGDGTATvGITDFAQAQLGDIVFVELPEVGTKVKKGESLAAIESVKAASPIYAPVSGEVVEVNEKLED 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 491320209   86 DPDFVNDEPYGKGWIYKIKPDNLADVEKLLSSSEYEA 122
Cdd:pfam01597  81 NPGLINKDPYEDGWIAKLKPSNLEELESLMTAEQYEK 117
GCS_H cd06848
Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage ...
 9-103 6.80e-47

Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-proteins) which catalyzes the oxidative cleavage of glycine. The H-protein shuttles the methylamine group of glycine from the P-protein (glycine dehydrogenase) to the T-protein (aminomethyltransferase) via a lipoyl group, attached to a completely conserved lysine residue.


Pssm-ID: 133457 [Multi-domain]  Cd Length: 96  Bit Score: 146.14  E-value: 6.80e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320209   9 YARTHEWVRIEGDLVVT-GISDHAQDALGDLVYVEAPEVGQQVTAGEQAGVVESVKTASDIHAPVSGTVVEINPALEDDP 87
Cdd:cd06848    1 YTKDHEWVKVEGDGIATvGITDYAQDLLGDIVFVELPEVGTEVKKGDPFGSVESVKAASDLYSPVSGEVVEVNEALLDNP 80

                         90
                 ....*....|....*.
gi 491320209  88 DFVNDEPYGKGWIYKI 103
Cdd:cd06848   81 ELINSDPYGEGWLVKI 96
PRK13380 PRK13380
glycine cleavage system protein H; Provisional
 4-120 1.91e-46

glycine cleavage system protein H; Provisional


Pssm-ID: 237370  Cd Length: 144  Bit Score: 146.69  E-value: 1.91e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320209   4 PSELKY-ARTHEWVRIEGDLVVT-GISDHAQDALGDLVYVEAPEVGQQVTAGEQAGVVESVKTASDIHAPVSGTVVEINP 81
Cdd:PRK13380  10 PSELRYtIKNHEWLRLEGDGTVTvGITDYAQTMAGDVVFVRLKELGKKVEKGKPVATLESGKWAGPVPAPLTGEVVEVNE 89

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 491320209  82 ALEDDPDFVNDEPYGKGWIYKIKPDNLADVEKLLSSSEY 120
Cdd:PRK13380  90 ALEDSPELVNEDPYGEGWFFRFKPANPEELKQLLDGDAA 128
PRK00624 PRK00624
glycine cleavage system protein H; Provisional
 9-114 2.34e-18

glycine cleavage system protein H; Provisional


Pssm-ID: 167014  Cd Length: 114  Bit Score: 74.48  E-value: 2.34e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491320209   9 YARTHEWVR-IEGDLVVTGISDHAQDALGDLVYVEAPEVGQQVTAGEQAGVVESVKTASDIHAPVSGTVVEINPALEDDP 87
Cdd:PRK00624   4 YSDYHVWIEpIHSRIVRLGLTSKMQENLGNILHIDLPSVGSFCKEGEVLVILESSKSAIEVLSPVSGEVIEVNTALEDDI 83

                         90       100
                 ....*....|....*....|....*..
gi 491320209  88 DFVNDEPYGKGWIYKIKPDNLADVEKL 114
Cdd:PRK00624  84 QPINNAPESEGWFVVVQLDEDFDSENL 110
Biotinyl_lipoyl_domains cd06663
Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the ...
 26-103 8.79e-10

Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl, or methylamine, respectively, between components of the complex/protein via a biotinyl or lipoyl group, which is covalently attached to a highly conserved lysine residue.


Pssm-ID: 133456 [Multi-domain]  Cd Length: 73  Bit Score: 51.29  E-value: 8.79e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491320209  26 GISDHAQDALGDLVYVEAPEVGQQVTAGEQAGVVESVKTASDIHAPVSGTVVEINPALeddpdfvNDEPYGKGWIYKI 103
Cdd:cd06663    3 LIPDLAQHLGDGTVVKWLKKVGDKVKKGDVLAEIEAMKATSDVEAPKSGTVKKVLVKE-------GTKVEGDTPLVKI 73
AccB COG0511
Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier ...
 45-79 5.66e-07

Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440277 [Multi-domain]  Cd Length: 136  Bit Score: 45.27  E-value: 5.66e-07
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 491320209  45 EVGQQVTAGEQAGVVESVKTASDIHAPVSGTVVEI 79
Cdd:COG0511   84 KVGDKVKAGDTLCIIEAMKMMNEIEAPVSGTVVEI 118
PRK09282 PRK09282
pyruvate carboxylase subunit B; Validated
 45-79 1.69e-06

pyruvate carboxylase subunit B; Validated


Pssm-ID: 236449 [Multi-domain]  Cd Length: 592  Bit Score: 45.22  E-value: 1.69e-06
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 491320209  45 EVGQQVTAGEQAGVVESVKTASDIHAPVSGTVVEI 79
Cdd:PRK09282 539 KEGDKVKAGDTVLVLEAMKMENEIQAPVDGTVKEI 573
biotinyl_domain cd06850
The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all ...
 45-80 7.04e-06

The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, transcarboxylase and urea amidolyase. This domain functions in transferring CO2 from one subsite to another, allowing carboxylation, decarboxylation, or transcarboxylation. During this process, biotin is covalently attached to a specific lysine.


Pssm-ID: 133459 [Multi-domain]  Cd Length: 67  Bit Score: 40.86  E-value: 7.04e-06
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 491320209  45 EVGQQVTAGEQAGVVESVKTASDIHAPVSGTVVEIN 80
Cdd:cd06850   16 KEGDKVEAGQPLAVLEAMKMENEVTAPVAGVVKEIL 51
PRK12999 PRK12999
pyruvate carboxylase; Reviewed
 36-79 2.74e-04

pyruvate carboxylase; Reviewed


Pssm-ID: 237263 [Multi-domain]  Cd Length: 1146  Bit Score: 38.97  E-value: 2.74e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 491320209   36 GDLVYVeAPEVGQQVTAGEQAGVVESVKTASDIHAPVSGTVVEI 79
Cdd:PRK12999 1085 GSVVTV-LVKEGDEVKAGDPLAVIEAMKMETTITAPVDGTVKRV 1127
PRK07051 PRK07051
biotin carboxyl carrier domain-containing protein;
45-79 5.18e-04

biotin carboxyl carrier domain-containing protein;


Pssm-ID: 180811 [Multi-domain]  Cd Length: 80  Bit Score: 36.14  E-value: 5.18e-04
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 491320209  45 EVGQQVTAGEQAGVVESVKTASDIHAPVSGTVVEI 79
Cdd:PRK07051  27 EVGDAVAAGDVVGLIEVMKQFTEVEAEAAGRVVEF 61
RnfC COG4656
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfC subunit [Energy production and ...
 45-83 6.34e-04

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfC subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfC subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 443694 [Multi-domain]  Cd Length: 451  Bit Score: 37.81  E-value: 6.34e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 491320209  45 EVGQQVTAGEQAGVVESVKTAsDIHAPVSGTVVEINPAL 83
Cdd:COG4656   50 KVGDKVLKGQLIAEADGFVSA-PVHAPVSGTVVAIEPAP 87
RnfC_N pfam13375
RnfC Barrel sandwich hybrid domain; This domain is part of the barrel sandwich hybrid ...
 45-81 8.73e-04

RnfC Barrel sandwich hybrid domain; This domain is part of the barrel sandwich hybrid superfamily. It is found at the N-terminus of the RnfC Electron transport complex protein. It appears to be most related to the N-terminal NQRA domain (pfam05896).


Pssm-ID: 433157 [Multi-domain]  Cd Length: 101  Bit Score: 35.99  E-value: 8.73e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 491320209   45 EVGQQVTAGEQAGVVESVKTAsDIHAPVSGTVVEINP 81
Cdd:pfam13375  47 KVGDRVLKGQKIAEADGFVSA-PVHASVSGTVKAIEP 82
PycA COG1038
Pyruvate carboxylase [Energy production and conversion]; Pyruvate carboxylase is part of the ...
 45-79 1.25e-03

Pyruvate carboxylase [Energy production and conversion]; Pyruvate carboxylase is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440660 [Multi-domain]  Cd Length: 1144  Bit Score: 36.98  E-value: 1.25e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 491320209   45 EVGQQVTAGEQAGVVESVKTASDIHAPVSGTVVEI 79
Cdd:COG1038  1093 KEGDEVKKGDPLLTIEAMKMETTITAPRDGTVKEV 1127
PTZ00144 PTZ00144
dihydrolipoamide succinyltransferase; Provisional
 46-80 2.05e-03

dihydrolipoamide succinyltransferase; Provisional


Pssm-ID: 240289 [Multi-domain]  Cd Length: 418  Bit Score: 36.58  E-value: 2.05e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 491320209  46 VGQQVTAGEQAGVVESVKTASDIHAPVSGTVVEIN 80
Cdd:PTZ00144  68 VGDYVKEDEVICIIETDKVSVDIRAPASGVITKIF 102
lipoyl_domain cd06849
Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. ...
 45-79 3.53e-03

Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid dehydrogenase (BCDH), contain at least three different enzymes, 2-oxo acid dehydrogenase (E1), dihydrolipoyl acyltransferase (E2) and dihydrolipoamide dehydrogenase (E3) and play a key role in redox regulation. E2, the central component of the complex, catalyzes the transfer of the acyl group of CoA from E1 to E3 via reductive acetylation of a lipoyl group covalently attached to a lysine residue.


Pssm-ID: 133458 [Multi-domain]  Cd Length: 74  Bit Score: 33.92  E-value: 3.53e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 491320209  45 EVGQQVTAGEQAGVVESVKTASDIHAPVSGTVVEI 79
Cdd:cd06849   23 KEGDSVEEGDVLAEVETDKATVEVEAPAAGVLAKI 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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