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Conserved domains on  [gi|491303189|ref|WP_005161192|]
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MULTISPECIES: transcriptional regulator AsnC [Yersinia]

Protein Classification

transcriptional regulator AsnC( domain architecture ID 11485253)

transcriptional regulator AsnC acts as an autogenously regulated activator of asparagine synthetase A transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 1-153 1.18e-121

DNA-binding transcriptional regulator AsnC; Provisional


:

Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 338.22  E-value: 1.18e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491303189   1 MSEIYQIDNLDRGILNALMENARTPYAELAKNFGVSPGTIHVRVEKMRQAGIITAACVHVNPKQLGYDVCCFIGIILKSA 80
Cdd:PRK11179   1 MMENYQIDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFIGIILKSA 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491303189  81 KDYPSALKKLESLEEVVEAYYTTGHYSIFIKVMCKSIDALQQVLINKIQTIDEIQSTETLISLQNPIMRTIVP 153
Cdd:PRK11179  81 KDYPSALAKLESLDEVVEAYYTTGHYSIFIKVMCRSIDALQHVLINKIQTIDEIQSTETLISLQNPIMRTIKP 153
 
Name Accession Description Interval E-value
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 1-153 1.18e-121

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 338.22  E-value: 1.18e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491303189   1 MSEIYQIDNLDRGILNALMENARTPYAELAKNFGVSPGTIHVRVEKMRQAGIITAACVHVNPKQLGYDVCCFIGIILKSA 80
Cdd:PRK11179   1 MMENYQIDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFIGIILKSA 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491303189  81 KDYPSALKKLESLEEVVEAYYTTGHYSIFIKVMCKSIDALQQVLINKIQTIDEIQSTETLISLQNPIMRTIVP 153
Cdd:PRK11179  81 KDYPSALAKLESLDEVVEAYYTTGHYSIFIKVMCRSIDALQHVLINKIQTIDEIQSTETLISLQNPIMRTIKP 153
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
5-143 1.58e-48

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 153.01  E-value: 1.58e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491303189   5 YQIDNLDRGILNALMENARTPYAELAKNFGVSPGTIHVRVEKMRQAGIITAACVHVNPKQLGYDVCCFIGIILKSaKDYP 84
Cdd:COG1522    1 MELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPP-HRLD 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 491303189  85 SALKKLESLEEVVEAYYTTGHYSIFIKVMCKSIDALQQVLINKIQTIDEIQSTETLISL 143
Cdd:COG1522   80 EFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 7-114 1.44e-40

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 131.87  E-value: 1.44e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491303189     7 IDNLDRGILNALMENARTPYAELAKNFGVSPGTIHVRVEKMRQAGIITAACVHVNPKQLGYDVCCFIGIILKSAKDYPSA 86
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENPDKLEEF 80

                           90       100
                   ....*....|....*....|....*...
gi 491303189    87 LKKLESLEEVVEAYYTTGHYSIFIKVMC 114
Cdd:smart00344  81 LEKLEKLPEVEEVYLVTGDYDYLLKVRA 108
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 73-144 7.18e-17

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 70.25  E-value: 7.18e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491303189   73 IGIILKSAKDYPSALKKLESLEEVVEAYYTTGHYSIFIKVMCKSIDALQQVLINKIQTIDEIQSTETLISLQ 144
Cdd:pfam01037   1 VEVKLEPGHALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVLS 72
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 8-55 1.52e-07

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 46.14  E-value: 1.52e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 491303189   8 DNLDRGILNALMENARTPyAELAKNFGVSPGTIHVRVEKMRQAGIITA 55
Cdd:cd00090    6 DPTRLRILRLLLEGPLTV-SELAERLGLSQSTVSRHLKKLEEAGLVES 52
 
Name Accession Description Interval E-value
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 1-153 1.18e-121

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 338.22  E-value: 1.18e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491303189   1 MSEIYQIDNLDRGILNALMENARTPYAELAKNFGVSPGTIHVRVEKMRQAGIITAACVHVNPKQLGYDVCCFIGIILKSA 80
Cdd:PRK11179   1 MMENYQIDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFIGIILKSA 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491303189  81 KDYPSALKKLESLEEVVEAYYTTGHYSIFIKVMCKSIDALQQVLINKIQTIDEIQSTETLISLQNPIMRTIVP 153
Cdd:PRK11179  81 KDYPSALAKLESLDEVVEAYYTTGHYSIFIKVMCRSIDALQHVLINKIQTIDEIQSTETLISLQNPIMRTIKP 153
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
5-143 1.58e-48

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 153.01  E-value: 1.58e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491303189   5 YQIDNLDRGILNALMENARTPYAELAKNFGVSPGTIHVRVEKMRQAGIITAACVHVNPKQLGYDVCCFIGIILKSaKDYP 84
Cdd:COG1522    1 MELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPP-HRLD 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 491303189  85 SALKKLESLEEVVEAYYTTGHYSIFIKVMCKSIDALQQVLINKIQTIDEIQSTETLISL 143
Cdd:COG1522   80 EFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 7-114 1.44e-40

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 131.87  E-value: 1.44e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491303189     7 IDNLDRGILNALMENARTPYAELAKNFGVSPGTIHVRVEKMRQAGIITAACVHVNPKQLGYDVCCFIGIILKSAKDYPSA 86
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENPDKLEEF 80

                           90       100
                   ....*....|....*....|....*...
gi 491303189    87 LKKLESLEEVVEAYYTTGHYSIFIKVMC 114
Cdd:smart00344  81 LEKLEKLPEVEEVYLVTGDYDYLLKVRA 108
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 73-144 7.18e-17

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 70.25  E-value: 7.18e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491303189   73 IGIILKSAKDYPSALKKLESLEEVVEAYYTTGHYSIFIKVMCKSIDALQQVLINKIQTIDEIQSTETLISLQ 144
Cdd:pfam01037   1 VEVKLEPGHALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVLS 72
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
8-48 4.38e-15

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 64.70  E-value: 4.38e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 491303189    8 DNLDRGILNALMENARTPYAELAKNFGVSPGTIHVRVEKMR 48
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
10-53 1.85e-11

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 55.52  E-value: 1.85e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 491303189   10 LDRGILNALMENARTPYAELAKNFGVSPGTIHVRVEKMRQAGII 53
Cdd:pfam13412   2 TDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
1-124 4.47e-09

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 52.07  E-value: 4.47e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491303189   1 MSEIYQIDNLDRGILNALMENARTPYAELAKNFGVSPGTIHVRVEKMRQAGIITAACVHVNPKQLGYDVCCFIGIILksA 80
Cdd:PRK11169   6 KRPGKDLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITL--N 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 491303189  81 KDYPSALKK----LESLEEVVEAYYTTGHYSIFIKVMCKSIDALQQVL 124
Cdd:PRK11169  84 RGAPDVFEQfnaaVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLL 131
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 8-55 1.52e-07

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 46.14  E-value: 1.52e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 491303189   8 DNLDRGILNALMENARTPyAELAKNFGVSPGTIHVRVEKMRQAGIITA 55
Cdd:cd00090    6 DPTRLRILRLLLEGPLTV-SELAERLGLSQSTVSRHLKKLEEAGLVES 52
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 12-54 3.25e-05

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 39.44  E-value: 3.25e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 491303189   12 RGILNALMENARTPYAELAKNFGVSPGTIHVRVEKMRQAGIIT 54
Cdd:pfam12840  13 LRILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVE 55
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
1-55 1.02e-04

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 39.63  E-value: 1.02e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491303189   1 MSEIYQIDN-LD-------RGILNALMENARTPYaELAKNFGVSPGTIHVRVEKMRQAGIITA 55
Cdd:COG1777    1 MSDDEDLDRlLDalgnptrRRILALLSEEPAYVS-ELARELGVSRQAVYKHLRKLEEAGLVES 62
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
11-55 3.97e-04

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 38.71  E-value: 3.97e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 491303189  11 DRGILNALMENARTPYAELAKNFGVSPGTIHVRVEKMRQAGIITA 55
Cdd:COG3398   99 PRRILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVER 143
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
14-55 1.07e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 35.65  E-value: 1.07e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 491303189    14 ILNALMENARTPyAELAKNFGVSPGTIHVRVEKMRQAGIITA 55
Cdd:smart00418   2 ILKLLAEGELCV-CELAEILGLSQSTVSHHLKKLREAGLVES 42
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
14-54 3.76e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 34.94  E-value: 3.76e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 491303189  14 ILNALMENARTPyAELAKNFGVSPGTIHVRVEKMRQAGIIT 54
Cdd:COG4189   24 ILRLLAEEPLNV-NELAEALGLPKSTVSYHIRKLEEAGLIR 63
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 14-53 4.10e-03

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 33.57  E-value: 4.10e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 491303189   14 ILNALMENARTPYaELAKNFGVSPGTI--HVRveKMRQAGII 53
Cdd:pfam01022   7 ILKLLAEGELCVC-ELAEELGLSQSTVshHLK--KLREAGLV 45
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 5-54 5.62e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 33.72  E-value: 5.62e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 491303189    5 YQIDNLDRGILNALMENA-RTPyAELAKNFGVSPGTIHVRVEKMRQAGIIT 54
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPgLTV-AELARRLGISKQTVSRLVKRLEAKGLVE 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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