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Conserved domains on  [gi|491301687|ref|WP_005159690|]
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GAF and ANTAR domain-containing protein [Amycolatopsis azurea]

Protein Classification

GAF and ANTAR domain-containing protein( domain architecture ID 10588503)

ANTAR (AmiR and NasR transcription antitermination regulator) domain-containing protein may bind RNA and cyclic nucleotides

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANTAR pfam03861
ANTAR domain; ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding ...
 203-248 6.85e-19

ANTAR domain; ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins. The majority of the domain consists of a coiled-coil.


:

Pssm-ID: 427550 [Multi-domain]  Cd Length: 46  Bit Score: 77.37  E-value: 6.85e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 491301687  203 AVESRDVIGQAKGILMQRRGLTADEAFDLLRRTSQDLNVKLAELAR 248
Cdd:pfam03861   1 ALESRKVIEQAKGILMERLGLSEDEAFRLLRKLSMDRNVKLREVAE 46
GAF_2 pfam13185
GAF domain; The GAF domain is named after some of the proteins it is found in, including ...
 39-185 1.19e-05

GAF domain; The GAF domain is named after some of the proteins it is found in, including cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. It is also found in guanylyl cyclases and phytochromes. The structure of a GAF domain shows that the domain shares a similar fold with the PAS domain. This domain can bind O2, CO and NO (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


:

Pssm-ID: 433019 [Multi-domain]  Cd Length: 137  Bit Score: 43.99  E-value: 1.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491301687   39 ASTPAQVLEQVIDAAYRVvPGADLVSITLRAPDGTFHTPVSTGEIALklDEVQYRAGTGPCVDAADSGSPgyIRSEDLAT 118
Cdd:pfam13185   1 AADLEELLDAVLEAAVEL-GASAVGFILLVDDDGRLAAWGGAADELS--AALDDPPGEGLVGEALRTGRP--VIVNDLAA 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 491301687  119 EKRWPDFSEAAvrHGYTAILSTVLVPDAtppRLPGALNIYSHRPGALDSLAQDTALLLATHGSLALA 185
Cdd:pfam13185  76 DPAKKGLPAGH--AGLRSFLSVPLVSGG---RVVGVLALGSNRPGAFDEEDLELLELLAEQAAIAIE 137
 
Name Accession Description Interval E-value
ANTAR pfam03861
ANTAR domain; ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding ...
 203-248 6.85e-19

ANTAR domain; ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins. The majority of the domain consists of a coiled-coil.


Pssm-ID: 427550 [Multi-domain]  Cd Length: 46  Bit Score: 77.37  E-value: 6.85e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 491301687  203 AVESRDVIGQAKGILMQRRGLTADEAFDLLRRTSQDLNVKLAELAR 248
Cdd:pfam03861   1 ALESRKVIEQAKGILMERLGLSEDEAFRLLRKLSMDRNVKLREVAE 46
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 182-259 5.24e-18

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 79.23  E-value: 5.24e-18
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491301687 182 LALASTTAVGRAELEASHLRLAVESRDVIGQAKGILMQRRGLTADEAFDLLRRTSQDLNVKLAELARTLAARHTELDT 259
Cdd:COG3707  117 LALARFRELRALRRELAKLREALEERKLIERAKGILMERRGLSEDEAYRLLRKQAMDRRVKLAEVAEAILAAAELLKG 194
ANTAR smart01012
ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found ...
 197-250 2.98e-17

ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; The majority of the domain consists of a coiled-coil.


Pssm-ID: 198080 [Multi-domain]  Cd Length: 55  Bit Score: 73.28  E-value: 2.98e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 491301687   197 ASHLRLAVESRDVIGQAKGILMQRRGLTADEAFDLLRRTSQDLNVKLAELARTL 250
Cdd:smart01012   1 LEQLREALESRKVIEQAKGILMERRGLSEEEAFELLRKLAMDRNVKLRDVAEAI 54
GAF_2 pfam13185
GAF domain; The GAF domain is named after some of the proteins it is found in, including ...
 39-185 1.19e-05

GAF domain; The GAF domain is named after some of the proteins it is found in, including cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. It is also found in guanylyl cyclases and phytochromes. The structure of a GAF domain shows that the domain shares a similar fold with the PAS domain. This domain can bind O2, CO and NO (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 433019 [Multi-domain]  Cd Length: 137  Bit Score: 43.99  E-value: 1.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491301687   39 ASTPAQVLEQVIDAAYRVvPGADLVSITLRAPDGTFHTPVSTGEIALklDEVQYRAGTGPCVDAADSGSPgyIRSEDLAT 118
Cdd:pfam13185   1 AADLEELLDAVLEAAVEL-GASAVGFILLVDDDGRLAAWGGAADELS--AALDDPPGEGLVGEALRTGRP--VIVNDLAA 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 491301687  119 EKRWPDFSEAAvrHGYTAILSTVLVPDAtppRLPGALNIYSHRPGALDSLAQDTALLLATHGSLALA 185
Cdd:pfam13185  76 DPAKKGLPAGH--AGLRSFLSVPLVSGG---RVVGVLALGSNRPGAFDEEDLELLELLAEQAAIAIE 137
 
Name Accession Description Interval E-value
ANTAR pfam03861
ANTAR domain; ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding ...
 203-248 6.85e-19

ANTAR domain; ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins. The majority of the domain consists of a coiled-coil.


Pssm-ID: 427550 [Multi-domain]  Cd Length: 46  Bit Score: 77.37  E-value: 6.85e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 491301687  203 AVESRDVIGQAKGILMQRRGLTADEAFDLLRRTSQDLNVKLAELAR 248
Cdd:pfam03861   1 ALESRKVIEQAKGILMERLGLSEDEAFRLLRKLSMDRNVKLREVAE 46
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 182-259 5.24e-18

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 79.23  E-value: 5.24e-18
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491301687 182 LALASTTAVGRAELEASHLRLAVESRDVIGQAKGILMQRRGLTADEAFDLLRRTSQDLNVKLAELARTLAARHTELDT 259
Cdd:COG3707  117 LALARFRELRALRRELAKLREALEERKLIERAKGILMERRGLSEDEAYRLLRKQAMDRRVKLAEVAEAILAAAELLKG 194
ANTAR smart01012
ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found ...
 197-250 2.98e-17

ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; The majority of the domain consists of a coiled-coil.


Pssm-ID: 198080 [Multi-domain]  Cd Length: 55  Bit Score: 73.28  E-value: 2.98e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 491301687   197 ASHLRLAVESRDVIGQAKGILMQRRGLTADEAFDLLRRTSQDLNVKLAELARTL 250
Cdd:smart01012   1 LEQLREALESRKVIEQAKGILMERRGLSEEEAFELLRKLAMDRNVKLRDVAEAI 54
GAF_2 pfam13185
GAF domain; The GAF domain is named after some of the proteins it is found in, including ...
 39-185 1.19e-05

GAF domain; The GAF domain is named after some of the proteins it is found in, including cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. It is also found in guanylyl cyclases and phytochromes. The structure of a GAF domain shows that the domain shares a similar fold with the PAS domain. This domain can bind O2, CO and NO (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 433019 [Multi-domain]  Cd Length: 137  Bit Score: 43.99  E-value: 1.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491301687   39 ASTPAQVLEQVIDAAYRVvPGADLVSITLRAPDGTFHTPVSTGEIALklDEVQYRAGTGPCVDAADSGSPgyIRSEDLAT 118
Cdd:pfam13185   1 AADLEELLDAVLEAAVEL-GASAVGFILLVDDDGRLAAWGGAADELS--AALDDPPGEGLVGEALRTGRP--VIVNDLAA 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 491301687  119 EKRWPDFSEAAvrHGYTAILSTVLVPDAtppRLPGALNIYSHRPGALDSLAQDTALLLATHGSLALA 185
Cdd:pfam13185  76 DPAKKGLPAGH--AGLRSFLSVPLVSGG---RVVGVLALGSNRPGAFDEEDLELLELLAEQAAIAIE 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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