CheW domain-containing protein similar to chemotaxis protein CheW that couples methyl-accepting chemoreceptors and histidine kinase CheA and is essential for chemotaxis
CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. ...
8-164
1.86e-84
CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and other related proteins that are involved in chemotaxis. The CheW-like regulatory domain in the chemotaxis associated histidine kinase CheA binds to CheW, suggesting that these domains can interact with each other.
The actual alignment was detected with superfamily member PRK10612:
Pssm-ID: 469692 Cd Length: 167 Bit Score: 245.49 E-value: 1.86e-84
CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. ...
23-156
3.54e-49
CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together with CheA and the methyl-accepting chemotaxis proteins (MCPs), which are involved in response modulation.
Pssm-ID: 238374 Cd Length: 140 Bit Score: 155.04 E-value: 3.54e-49
CheW-like domain; CheW proteins are part of the chemotaxis signaling mechanism in bacteria. ...
20-151
2.75e-36
CheW-like domain; CheW proteins are part of the chemotaxis signaling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and other related proteins that are involved in chemotaxis. The CheW-like regulatory domain in CheA binds to CheW, suggesting that these domains can interact with each other.
Pssm-ID: 460257 [Multi-domain] Cd Length: 131 Bit Score: 121.92 E-value: 2.75e-36
CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. ...
23-156
3.54e-49
CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together with CheA and the methyl-accepting chemotaxis proteins (MCPs), which are involved in response modulation.
Pssm-ID: 238374 Cd Length: 140 Bit Score: 155.04 E-value: 3.54e-49
CheW-like domain; CheW proteins are part of the chemotaxis signaling mechanism in bacteria. ...
20-151
2.75e-36
CheW-like domain; CheW proteins are part of the chemotaxis signaling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and other related proteins that are involved in chemotaxis. The CheW-like regulatory domain in CheA binds to CheW, suggesting that these domains can interact with each other.
Pssm-ID: 460257 [Multi-domain] Cd Length: 131 Bit Score: 121.92 E-value: 2.75e-36
CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. ...
21-151
6.24e-30
CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and other related proteins that are involved in chemotaxis. The CheW-like regulatory domain in the chemotaxis associated histidine kinase CheA binds to CheW, suggesting that these domains can interact with each other.
Pssm-ID: 238331 Cd Length: 136 Bit Score: 106.20 E-value: 6.24e-30
CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. ...
21-118
4.50e-04
CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling mechanism is modulated by the methyl accepting chemotaxis proteins (MCPs). MCPs form a highly interconnected, tightly packed array within the membrane that is organized, at least in part, through interactions with CheW and CheA. The CheA regulatory domain belongs to the family of CheW_like proteins and has been proposed to mediate interaction with the kinase regulator CheW.
Pssm-ID: 238373 [Multi-domain] Cd Length: 132 Bit Score: 38.31 E-value: 4.50e-04
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
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