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Conserved domains on  [gi|491047347|ref|WP_004909001|]
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MULTISPECIES: glucosamine-6-phosphate deaminase [Providencia]

Protein Classification

glucosamine-6-phosphate deaminase( domain architecture ID 10011441)

glucosamine-6-phosphate deaminase catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and an ammonium ion

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
 1-261 8.37e-174

glucosamine-6-phosphate deaminase; Provisional


:

Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 479.33  E-value: 8.37e-174
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347   1 MRLIPLNNAHDVGIWSAQYIADKINAFNPTADRPFVLGLPTGGTPLATYKALIALYNAGKVSFKHVVTFNMDEYIGIPAN 80
Cdd:PRK00443   1 MRLIILKTAEEVGKWAARHIANRINAFLPTKERPFVLGLATGSSPLETYKALIELHKAGKVDFSRVTTFNLDEYVGLPAD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347  81 HPQSYHTFMHENFFNHIDIQAQNINLLNGNAPDVDAECQRYEDKIKSYGKINLFMGGVGNDGHIAFNEPGSSLNSRTRIK 160
Cdd:PRK00443  81 HPESYRYFMRENFFDHVDIPPENINLLNGNAPDPEAECRRYEEKIKSAGGIDLQILGIGENGHIAFNEPGSSFASRTRIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347 161 TLTPETRQANSRFFDNDINQVPKFALTVGVATLMDAEELMVLATGANKANAVHAAVEGSINHMWTVSCVQMHPKALVVCD 240
Cdd:PRK00443 161 TLTEDTRIANSRFFDGDIEQVPKYALTVGVGTILDAKEIMLLAPGHNKAEAVKAAVEGPVNHMWPASILQLHPKATLVLD 240

                        250       260
                 ....*....|....*....|.
gi 491047347 241 EPATLELKVKTLKYFKQLESE 261
Cdd:PRK00443 241 EAAASELKVKTVKYFTELEAE 261
 
Name Accession Description Interval E-value
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
 1-261 8.37e-174

glucosamine-6-phosphate deaminase; Provisional


Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 479.33  E-value: 8.37e-174
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347   1 MRLIPLNNAHDVGIWSAQYIADKINAFNPTADRPFVLGLPTGGTPLATYKALIALYNAGKVSFKHVVTFNMDEYIGIPAN 80
Cdd:PRK00443   1 MRLIILKTAEEVGKWAARHIANRINAFLPTKERPFVLGLATGSSPLETYKALIELHKAGKVDFSRVTTFNLDEYVGLPAD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347  81 HPQSYHTFMHENFFNHIDIQAQNINLLNGNAPDVDAECQRYEDKIKSYGKINLFMGGVGNDGHIAFNEPGSSLNSRTRIK 160
Cdd:PRK00443  81 HPESYRYFMRENFFDHVDIPPENINLLNGNAPDPEAECRRYEEKIKSAGGIDLQILGIGENGHIAFNEPGSSFASRTRIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347 161 TLTPETRQANSRFFDNDINQVPKFALTVGVATLMDAEELMVLATGANKANAVHAAVEGSINHMWTVSCVQMHPKALVVCD 240
Cdd:PRK00443 161 TLTEDTRIANSRFFDGDIEQVPKYALTVGVGTILDAKEIMLLAPGHNKAEAVKAAVEGPVNHMWPASILQLHPKATLVLD 240

                        250       260
                 ....*....|....*....|.
gi 491047347 241 EPATLELKVKTLKYFKQLESE 261
Cdd:PRK00443 241 EAAASELKVKTVKYFTELEAE 261
nagB TIGR00502
glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a ...
 1-259 6.65e-163

glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a closely related pair from Bacillus subtilis, one of which is uncharacterized but included as a member of the orthologous set. [Central intermediary metabolism, Amino sugars]


Pssm-ID: 129593  Cd Length: 259  Bit Score: 451.96  E-value: 6.65e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347    1 MRLIPLNNAHDVGIWSAQYIADKINAFNPTADRPFVLGLPTGGTPLATYKALIALYNAGKVSFKHVVTFNMDEYIGIPAN 80
Cdd:TIGR00502   1 MRLIILQTYEELSKWAARHIANRINEFKPTAARPFVLGLPTGGTPIGTYKQLIELHQAGKISFQNVTTFNMDEYAGLSEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347   81 HPQSYHTFMHENFFNHIDIQAQNINLLNGNAPDVDAECQRYEDKIKSYGKINLFMGGVGNDGHIAFNEPGSSLNSRTRIK 160
Cdd:TIGR00502  81 HPESYHSFMHNNFFQHIDIKPENINILNGNAPDLEAECRRYEEKIRSYGGIDLFMGGIGPDGHIAFNEPGSSLTSRTRIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347  161 TLTPETRQANSRFFDNDINQVPKFALTVGVATLMDAEELMVLATGANKANAVHAAVEGSINHMWTVSCVQMHPKALVVCD 240
Cdd:TIGR00502 161 TLTEDTIQANSRFFEGDVNQVPKYALTVGIGTILDSKEVLILVSGHQKALALQKAVEGGVNHMWTISALQLHKHAIVVCD 240

                         250
                  ....*....|....*....
gi 491047347  241 EPATLELKVKTLKYFKQLE 259
Cdd:TIGR00502 241 ENATQELKVKTVEYFNELE 259
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 11-247 4.42e-134

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 377.98  E-value: 4.42e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347  11 DVGIWSAQYIADKINAFnptadRPFVLGLPTGGTPLATYKALIALYNAGKVSFKHVVTFNMDEYIGIPANHPQSYHTFMH 90
Cdd:cd01399    2 EMSEAAAELIAELIREK-----PPAVLGLATGSTPLGVYEELIELHKEGGLSFSNVTTFNLDEYVGLPPDHPQSYHYFMR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347  91 ENFFNHIDIQAQNINLLNGNAPDVDAECQRYEDKIKSYGKINLFMGGVGNDGHIAFNEPGSSLNSRTRIKTLTPETRQAN 170
Cdd:cd01399   77 ENLFDHIDIKPENIHIPDGNAADLEAECRRYEALIAEAGGIDLQLLGIGENGHIGFNEPGSSLDSRTRVVTLDESTRQAN 156

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 491047347 171 SRFFDNDiNQVPKFALTVGVATLMDAEELMVLATGANKANAVHAAVEGSINHMWTVSCVQMHPKALVVCDEPATLEL 247
Cdd:cd01399  157 ARFFDGD-EDVPTQAITMGIGTIMKAKEILLLATGEGKAEAVKKALEGPVTEECPASILQLHPNVTVILDEAAASEL 232
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 1-248 1.13e-119

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 342.14  E-value: 1.13e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347   1 MRLIPLNNAHDVGIWSAQYIADKINAFnpTADRP-FVLGLPTGGTPLATYKALIALYNAGKVSFKHVVTFNMDEYIGIPA 79
Cdd:COG0363    2 MRVIIFPDAEELAAAAAERAAERIAEA--IAEKGrAVLGLAGGSTPLGLYEELARLHKEGGLDWSRVHVFNLDEYVGLPP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347  80 NHPQSYHTFMHENFFNHIDIQAQNINLLNGNAPDVDAECQRYEDKIKSYGKINLFMGGVGNDGHIAFNEPGSSLNSRT-R 158
Cdd:COG0363   80 DHPQSNRRFMREALLDHVDIPPENIHIPDGEAEDPEAAAARYEALIAEAGGIDLQLLGIGEDGHIAFNFPGSPFLSETdR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347 159 IKTLTPETRQANSRFFDNdINQVPKFALTVGVATLMDAEELMVLATGANKANAVHAAVEGSINHMWTVSCVQMHPKALVV 238
Cdd:COG0363  160 VVTLDESTRQANARFFGS-IPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEEVPASILQGHPNVTWF 238

                        250
                 ....*....|
gi 491047347 239 CDEPATLELK 248
Cdd:COG0363  239 LDEAAASLLT 248
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
17-232 2.01e-22

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 91.92  E-value: 2.01e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347   17 AQYIADKINAFnpTADR-PFVLGLPTGGTPLATYKALIALYNAgkVSFKHVVTFNMDEYIgIPANHPQSYHTFMHENFFN 95
Cdd:pfam01182  11 AERLAEALEAA--LAERgRFTLALSGGSTPKPLYELLAAAPAR--LDWSRVHVFWGDERC-VPPDDPDSNYGMAREALLS 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347   96 HIDIQAQNINLLNGNAPDVDAECQRYEDKIKSYGKIN------LFMGGVGNDGHIA--FnePGS-SLNSRTRIKTLtpet 166
Cdd:pfam01182  86 HVPIPASNVHPIPASAADPEEAAAAYEAELRELLPDLelpvfdLVLLGMGPDGHTAslF--PGSpALEETDRLVVA---- 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491047347  167 rqansrffdndINQVPKFA---LTVGVATLMDAEELMVLATGANKANAVHAAVEGSiNHMWTVSCVQMH 232
Cdd:pfam01182 160 -----------VTDSPKPPperITLTLPVLNAARRVWFLVTGAGKADALRRALAGD-PDPLPAALVRPG 216
 
Name Accession Description Interval E-value
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
 1-261 8.37e-174

glucosamine-6-phosphate deaminase; Provisional


Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 479.33  E-value: 8.37e-174
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347   1 MRLIPLNNAHDVGIWSAQYIADKINAFNPTADRPFVLGLPTGGTPLATYKALIALYNAGKVSFKHVVTFNMDEYIGIPAN 80
Cdd:PRK00443   1 MRLIILKTAEEVGKWAARHIANRINAFLPTKERPFVLGLATGSSPLETYKALIELHKAGKVDFSRVTTFNLDEYVGLPAD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347  81 HPQSYHTFMHENFFNHIDIQAQNINLLNGNAPDVDAECQRYEDKIKSYGKINLFMGGVGNDGHIAFNEPGSSLNSRTRIK 160
Cdd:PRK00443  81 HPESYRYFMRENFFDHVDIPPENINLLNGNAPDPEAECRRYEEKIKSAGGIDLQILGIGENGHIAFNEPGSSFASRTRIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347 161 TLTPETRQANSRFFDNDINQVPKFALTVGVATLMDAEELMVLATGANKANAVHAAVEGSINHMWTVSCVQMHPKALVVCD 240
Cdd:PRK00443 161 TLTEDTRIANSRFFDGDIEQVPKYALTVGVGTILDAKEIMLLAPGHNKAEAVKAAVEGPVNHMWPASILQLHPKATLVLD 240

                        250       260
                 ....*....|....*....|.
gi 491047347 241 EPATLELKVKTLKYFKQLESE 261
Cdd:PRK00443 241 EAAASELKVKTVKYFTELEAE 261
nagB TIGR00502
glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a ...
 1-259 6.65e-163

glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a closely related pair from Bacillus subtilis, one of which is uncharacterized but included as a member of the orthologous set. [Central intermediary metabolism, Amino sugars]


Pssm-ID: 129593  Cd Length: 259  Bit Score: 451.96  E-value: 6.65e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347    1 MRLIPLNNAHDVGIWSAQYIADKINAFNPTADRPFVLGLPTGGTPLATYKALIALYNAGKVSFKHVVTFNMDEYIGIPAN 80
Cdd:TIGR00502   1 MRLIILQTYEELSKWAARHIANRINEFKPTAARPFVLGLPTGGTPIGTYKQLIELHQAGKISFQNVTTFNMDEYAGLSEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347   81 HPQSYHTFMHENFFNHIDIQAQNINLLNGNAPDVDAECQRYEDKIKSYGKINLFMGGVGNDGHIAFNEPGSSLNSRTRIK 160
Cdd:TIGR00502  81 HPESYHSFMHNNFFQHIDIKPENINILNGNAPDLEAECRRYEEKIRSYGGIDLFMGGIGPDGHIAFNEPGSSLTSRTRIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347  161 TLTPETRQANSRFFDNDINQVPKFALTVGVATLMDAEELMVLATGANKANAVHAAVEGSINHMWTVSCVQMHPKALVVCD 240
Cdd:TIGR00502 161 TLTEDTIQANSRFFEGDVNQVPKYALTVGIGTILDSKEVLILVSGHQKALALQKAVEGGVNHMWTISALQLHKHAIVVCD 240

                         250
                  ....*....|....*....
gi 491047347  241 EPATLELKVKTLKYFKQLE 259
Cdd:TIGR00502 241 ENATQELKVKTVEYFNELE 259
PTZ00285 PTZ00285
glucosamine-6-phosphate isomerase; Provisional
 1-253 1.65e-147

glucosamine-6-phosphate isomerase; Provisional


Pssm-ID: 140308  Cd Length: 253  Bit Score: 412.61  E-value: 1.65e-147
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347   1 MRLIPLNNAHDVGIWSAQYIADKINAFNPTADRPFVLGLPTGGTPLATYKALIALYNAGKVSFKHVVTFNMDEYIGIPAN 80
Cdd:PTZ00285   1 MRIVISEDADAVADYTSNYIIKRINDFKPTSDRPFVLGLPTGSTPLPTYQELIRAYREGRVSFSNVVTFNMDEYVGLPRD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347  81 HPQSYHTFMHENFFNHIDIQAQNINLLNGNAPDVDAECQRYEDKIKSYGKINLFMGGVGNDGHIAFNEPGSSLNSRTRIK 160
Cdd:PTZ00285  81 HPQSYHYFMKENFFDHVDIKEENRHILNGTAPDLEEECRRYEEKIRAVGGIDLFLAGIGTDGHIAFNEPGSSLDSRTRVK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347 161 TLTPETRQANSRFFDNDINQVPKFALTVGVATLMDAEELMVLATGANKANAVHAAVEGSINHMWTVSCVQMHPKALVVCD 240
Cdd:PTZ00285 161 SLNQETIDANARFFGNDISKVPTMALTVGIRTIMEAREVLLLATGASKAIAVARCVEGGVTHMCPASALQMHPAAVLCLD 240

                        250
                 ....*....|...
gi 491047347 241 EPATLELKVKTLK 253
Cdd:PTZ00285 241 EDATLELKVKTTK 253
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 11-247 4.42e-134

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 377.98  E-value: 4.42e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347  11 DVGIWSAQYIADKINAFnptadRPFVLGLPTGGTPLATYKALIALYNAGKVSFKHVVTFNMDEYIGIPANHPQSYHTFMH 90
Cdd:cd01399    2 EMSEAAAELIAELIREK-----PPAVLGLATGSTPLGVYEELIELHKEGGLSFSNVTTFNLDEYVGLPPDHPQSYHYFMR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347  91 ENFFNHIDIQAQNINLLNGNAPDVDAECQRYEDKIKSYGKINLFMGGVGNDGHIAFNEPGSSLNSRTRIKTLTPETRQAN 170
Cdd:cd01399   77 ENLFDHIDIKPENIHIPDGNAADLEAECRRYEALIAEAGGIDLQLLGIGENGHIGFNEPGSSLDSRTRVVTLDESTRQAN 156

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 491047347 171 SRFFDNDiNQVPKFALTVGVATLMDAEELMVLATGANKANAVHAAVEGSINHMWTVSCVQMHPKALVVCDEPATLEL 247
Cdd:cd01399  157 ARFFDGD-EDVPTQAITMGIGTIMKAKEILLLATGEGKAEAVKKALEGPVTEECPASILQLHPNVTVILDEAAASEL 232
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 1-248 1.13e-119

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 342.14  E-value: 1.13e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347   1 MRLIPLNNAHDVGIWSAQYIADKINAFnpTADRP-FVLGLPTGGTPLATYKALIALYNAGKVSFKHVVTFNMDEYIGIPA 79
Cdd:COG0363    2 MRVIIFPDAEELAAAAAERAAERIAEA--IAEKGrAVLGLAGGSTPLGLYEELARLHKEGGLDWSRVHVFNLDEYVGLPP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347  80 NHPQSYHTFMHENFFNHIDIQAQNINLLNGNAPDVDAECQRYEDKIKSYGKINLFMGGVGNDGHIAFNEPGSSLNSRT-R 158
Cdd:COG0363   80 DHPQSNRRFMREALLDHVDIPPENIHIPDGEAEDPEAAAARYEALIAEAGGIDLQLLGIGEDGHIAFNFPGSPFLSETdR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347 159 IKTLTPETRQANSRFFDNdINQVPKFALTVGVATLMDAEELMVLATGANKANAVHAAVEGSINHMWTVSCVQMHPKALVV 238
Cdd:COG0363  160 VVTLDESTRQANARFFGS-IPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEEVPASILQGHPNVTWF 238

                        250
                 ....*....|
gi 491047347 239 CDEPATLELK 248
Cdd:COG0363  239 LDEAAASLLT 248
PRK02122 PRK02122
glucosamine-6-phosphate deaminase-like protein; Validated
 17-247 1.39e-79

glucosamine-6-phosphate deaminase-like protein; Validated


Pssm-ID: 235005 [Multi-domain]  Cd Length: 652  Bit Score: 252.26  E-value: 1.39e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347  17 AQYIADKINAFNpTADRPFVLGLPTGGTPLATYKALIALYNAGKVSFKHVVTFNMDEYIGIPANHPQSYHTFMHENFFNH 96
Cdd:PRK02122  44 AQEIATLIRERQ-AEGKPCVLGLATGSSPIGVYAELIRMHREEGLSFKNVITFNLDEYYPMQPDSLQSYHRFMKENLFDH 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347  97 IDIQAQNINLLNGNAP--DVDAECQRYEDKIKSYGKINLFMGGVGNDGHIAFNEPGSSLNSRTRIKTLTPETRQANSRFF 174
Cdd:PRK02122 123 VDIPPENIHIPDGTIPkeEIDEYCRDYEEKIEAAGGIDFQLLGIGRTGHIGFNEPGSGRNSRTRLVTLDHITRRDAASDF 202

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491047347 175 dNDINQVPKFALTVGVATLMDAEELMVLATGANKANAVHAAVEGSINHMWTVSCVQMHPKALVVCDEPATLEL 247
Cdd:PRK02122 203 -FGEENVPRKAITMGVGTILKARRIVLLAWGEHKAPIIKRAVEGEISDEVPASYLQEHPNATFVLDLAAASEL 274
SugarP_isomerase cd00458
SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate ...
 15-239 1.06e-53

SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium, the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate. 6PGL converts 6-phosphoglucono-1,5-lactone to 6-phosphogluconate, the second step of the oxidative phase of the pentose phosphate pathway.


Pssm-ID: 238258  Cd Length: 169  Bit Score: 171.77  E-value: 1.06e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347  15 WSAQYIADKINAFnPTADRPFVLGLPTGGTPLATYKALIALYNAGkvSFKHVVTFNMDEYIGIPaNHPQSYHTFMHENFF 94
Cdd:cd00458    3 EALKFIEDK*EKL-LEEKDDMVIGLGTGSTPAYFYKLLGEKLKRG--EISDIVGFPTDERYVPL-DSDQSNFRQAKLLAF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347  95 NHIDIQAQNINLLNGNAPDVDAECQRYEDKIKSYGKINLFMGGVGNdghiafnepgsslnsrtriktltpetrqansrff 174
Cdd:cd00458   79 EHDIIPASNVHYVDTSLPIEKACEKYEREILDQVDAIDLAVDGAGY---------------------------------- 124

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491047347 175 dndinqvpkfaltvgvatlmDAEELMVLATGANKANAVHAAVEGSINHMWTVSCVQMHPKALVVC 239
Cdd:cd00458  125 --------------------RAGTVIVLVDGRKKVDYLCQNTEPGVIENGIFADIRGKEKDIVIV 169
PRK09762 PRK09762
galactosamine-6-phosphate isomerase; Provisional
 36-239 1.30e-30

galactosamine-6-phosphate isomerase; Provisional


Pssm-ID: 182064  Cd Length: 232  Bit Score: 114.16  E-value: 1.30e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347  36 VLGLPTGGTPLATYKALIALYNAGKVSFKHVVTFNMDEYIGIPANHPQSYHTFMHENFFNHIDIQAQNINLLNGNAPDvD 115
Cdd:PRK09762  31 VICLATGATPLLTYHYLVEKIHQQQVDVSQLTFVKLDEWVDLPLTMPGTCETFLQQHIVQPLGLREDQLISFRSEEIN-E 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347 116 AECQRYEDKIKSYGKINLFMGGVGNDGHIAFNEPGSSLNSRTRIKTLTPETRQANSRFFDndiNQVPKFALTVGVATLMD 195
Cdd:PRK09762 110 TECERVTNLIARKGGLDLCVLGLGKNGHLGLNEPGESLQPACHISQLDARTQQHEMLKTA---GRPVTRGITLGLKDILN 186

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 491047347 196 AEELMVLATGANKANAVHAAVEGSINHMWTVSCVQMHPKalVVC 239
Cdd:PRK09762 187 AREVLLLVTGEGKQDATERFLTAKVSTAIPASFLWLHSN--FIC 228
PRK12358 PRK12358
glucosamine-6-phosphate deaminase;
1-247 9.02e-23

glucosamine-6-phosphate deaminase;


Pssm-ID: 183470  Cd Length: 239  Bit Score: 93.28  E-value: 9.02e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347   1 MRLIPLNNAHDVGIWSAQYIADKInafnpTADRPFVLGLPTGGTPLATYKALIALYNaGKVSFKHVVTFNMDEyigIPAN 80
Cdd:PRK12358   1 MKIIITKDYEEMSRVAAHHLLGYM-----SKTKRVNLAITAGSTPKGMYEYLITLVK-GKAWYDNVHYYNFDE---IPFR 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347  81 HPQSYH---TFMHENFFNHIDIQAQNINLLN-GNApdvdaecQRYEDKIKSYGKINLFMGGVGNDGHIAFNEPG-SSLNS 155
Cdd:PRK12358  72 GKEGEGvtiTNLRNLFFTPAGIKEENIHKLTiDNY-------REHDQKLARDGGLDLVVLGLGADGHFCGNLPGtTHFHD 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347 156 RTRIKTLTPETRQANSRFFDN-DINQVPKFALTVGVATLMDAEELMVLATGANKANAVHAAVEGSINHMWTVSCVQMHPK 234
Cdd:PRK12358 145 ETVEVPIQGEMVDIVAHGELGgDFSLVPDSYVTMGPKSIMAAKNLLLIVNGKGKAQILKKVLQGPVTEDVPASILQLHPN 224

                        250
                 ....*....|...
gi 491047347 235 ALVVCDEPATLEL 247
Cdd:PRK12358 225 LTVILDEAAAAEL 237
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
17-232 2.01e-22

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 91.92  E-value: 2.01e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347   17 AQYIADKINAFnpTADR-PFVLGLPTGGTPLATYKALIALYNAgkVSFKHVVTFNMDEYIgIPANHPQSYHTFMHENFFN 95
Cdd:pfam01182  11 AERLAEALEAA--LAERgRFTLALSGGSTPKPLYELLAAAPAR--LDWSRVHVFWGDERC-VPPDDPDSNYGMAREALLS 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347   96 HIDIQAQNINLLNGNAPDVDAECQRYEDKIKSYGKIN------LFMGGVGNDGHIA--FnePGS-SLNSRTRIKTLtpet 166
Cdd:pfam01182  86 HVPIPASNVHPIPASAADPEEAAAAYEAELRELLPDLelpvfdLVLLGMGPDGHTAslF--PGSpALEETDRLVVA---- 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491047347  167 rqansrffdndINQVPKFA---LTVGVATLMDAEELMVLATGANKANAVHAAVEGSiNHMWTVSCVQMH 232
Cdd:pfam01182 160 -----------VTDSPKPPperITLTLPVLNAARRVWFLVTGAGKADALRRALAGD-PDPLPAALVRPG 216
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
 17-233 4.36e-20

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 85.69  E-value: 4.36e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347  17 AQYIADKINAFnPTADRPFVLGLPTGGTPLATYKALIALYnagKVSFKHVVTFNMDEYIgIPANHPQSYHTFMHENFFNH 96
Cdd:cd01400    8 ADRIAEALAAA-IAKRGRFSLALSGGSTPKPLYELLAAAP---ALDWSKVHVFLGDERC-VPPDDPDSNYRLAREALLSH 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347  97 IDIQAQNINLLNGNApDVDAECQRYEDKIKS----YGKINLFMGGVGNDGHIA--FnePGSSLNSRTRIKTLTPETrqan 170
Cdd:cd01400   83 VAIPAANIHPIPTEL-GPEDAAAAYEKELRAlfggVPPFDLVLLGMGPDGHTAslF--PGHPALLEETDRLVVAVT---- 155

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491047347 171 srffdnDINQVPKFALTVGVATLMDAEELMVLATGANKANAVHAAVEGSINHMWTVSCVQMHP 233
Cdd:cd01400  156 ------DSPKPPPERITLTLPVLNNARRVVFLVTGAEKAEALKRALAGPDPEELPAARVLPRP 212
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 8-247 6.58e-18

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 80.11  E-value: 6.58e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347    8 NAHDVGIWSAQYIADKINAFNPTADRpFVLGLPTGGTPLATYKALIALynagKVSFKHVVTFNMDEYIgIPANHPQSYHT 87
Cdd:TIGR01198   4 NSAELAEALAERIATKLQTALAERGQ-FSLALSGGRSPIALLEALAAQ----PLDWSRIHLFLGDERY-VPLDHADSNTG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347   88 FMHENFFNHIDIQAQNINLLNGNAPDVDAECQRYEDKIKSY------GKINLFMGGVGNDGHIAFNEPGSSLnSRTRIKT 161
Cdd:TIGR01198  78 LAREALLDRVAIPASNIHPMPTELSDIEEAAELYEQELAAAfqpivfPVFDLLLLGMGPDGHTASLFPHTPA-LQETERL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347  162 LTPETrqansrffdNDINQvPKFALTVGVATLMDAEELMVLATGANKANAVHAAVE-GSINHMWTVSCVQMHPKALVVCD 240
Cdd:TIGR01198 157 VTVLT---------KSPKP-PHERITLTLPAINAARKVFLLIAGEEKRNALAEALAvEAEPYPLPAAGVLHSGKTLWLLD 226


                  ....*..
gi 491047347  241 EPATLEL 247
Cdd:TIGR01198 227 YAAARKL 233
PLN02360 PLN02360
probable 6-phosphogluconolactonase
 69-217 7.68e-05

probable 6-phosphogluconolactonase


Pssm-ID: 166001 [Multi-domain]  Cd Length: 268  Bit Score: 42.92  E-value: 7.68e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347  69 FNMDEYIgIPANHPQSYHTFMHENFFNHIDIQAQNINLLNGNAPDVDAECQrYEDKIKSYGKI--------------NLF 134
Cdd:PLN02360  77 FWADERV-VAKNHADSNYKLAKDGLLSKVPVVPSHVYSINDTVTAEEAATD-YEFAIRQLVKTrtigvsdisdcpkfDLI 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491047347 135 MGGVGNDGHIAFNEPG-SSLNSRTRIKTltpetrqansrfFDNDINQVPKFALTVGVATLMDAEELMVLATGANKANAVH 213
Cdd:PLN02360 155 LLGMGSDGHVASLFPNhPALEEKDDWVT------------FITDSPKPPPERITFTLPVINSASNVAVVATGESKANAVH 222


                 ....
gi 491047347 214 AAVE 217
Cdd:PLN02360 223 LAID 226
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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