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Conserved domains on  [gi|491046388|ref|WP_004908042|]
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MULTISPECIES: type VI secretion system ATPase TssH [Providencia]

Protein Classification

ATP-dependent Clp protease ATP-binding subunit( domain architecture ID 11496630)

ClpA/ClpB family ATP-dependent Clp protease ATP-binding subunit is a component of the Clp chaperone-protease complex that is involved in protein degradation and disaggregation

Gene Ontology:  GO:0005524|GO:0016887|GO:0005737
PubMed:  2185473|11868279|16879409|9927482

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VI_ClpV1 TIGR03345
type VI secretion ATPase, ClpV1 family; Members of this protein family are homologs of ClpB, ...
 13-859 0e+00

type VI secretion ATPase, ClpV1 family; Members of this protein family are homologs of ClpB, an ATPase associated with chaperone-related functions. These ClpB homologs, designated ClpV1, are a key component of the bacterial pathogenicity-associated type VI secretion system. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


:

Pssm-ID: 274528 [Multi-domain]  Cd Length: 852  Bit Score: 1156.62  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388   13 LHPIAKHALESAAAYCVSHQQPEITIAQFLQKLIETPLTDIRLISQKSTLDINKLSELLDIQIPPHQAITQSYPSFSPLL 92
Cdd:TIGR03345   1 LNPTSRRALEQAAALCVARGHPEVELEHWLLALLDQPDSDLAAILRHFGVDLGRLKADLARALDKLPRGNTRTPVFSPHL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388   93 VEWMKDSWLLASTEFNHSELRSGVLFLTLLQMP-LRYLPKPVADMLSQVNREQLKLSFDKWTEGSAESP---FDEQAPQN 168
Cdd:TIGR03345  81 VELLQEAWLLASLELGDGRIRSGHLLLALLTDPeLRRLLGSISPELAKIDREALREALPALVEGSAEASaaaADAAPAGA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  169 NGKIASDSLLAKFTQNMTEQARNNELDPVLCRDHEIDLMIDILCRRRKNNPVVVGEPGVGKSALIEGLALRIIAGEIPEK 248
Cdd:TIGR03345 161 AAGAAGTSALDQYTTDLTAQAREGKIDPVLGRDDEIRQMIDILLRRRQNNPILTGEAGVGKTAVVEGLALRIAAGDVPPA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  249 LRGCELLTLDLGALQAGAAVKGEFEKRFKGIMQEVSQSPHPIILFIDEAHTLIGAGNQQGGLDVSNLLKPALARGELRTI 328
Cdd:TIGR03345 241 LRNVRLLSLDLGLLQAGASVKGEFENRLKSVIDEVKASPQPIILFIDEAHTLIGAGGQAGQGDAANLLKPALARGELRTI 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  329 AATTWSEYKKYFEKDAALARRFQLVQVKEPTSADAIIIMRGLRAIYEKAHNVFIDDEALRASAELSERYISGRQLPDKAI 408
Cdd:TIGR03345 321 AATTWAEYKKYFEKDPALTRRFQVVKVEEPDEETAIRMLRGLAPVLEKHHGVLILDEAVVAAVELSHRYIPGRQLPDKAV 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  409 DVLDTACARAAINLSSPPKMLSSLKTDLQQIEMETAILKREHHLGLDnHSERLEELASKANEIEQKASDIQQAWEQQQAL 488
Cdd:TIGR03345 401 SLLDTACARVALSQNATPAALEDLRRRIAALELELDALEREAALGAD-HDERLAELRAELAALEAELAALEARWQQEKEL 479

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  489 VSQIITLRSTLLDDENTEPQPEetcqvDELKQELQTLDQQLAQLHETHLLVSPHVDKKQIAAVIAEWTGVPLNRLSQDAL 568
Cdd:TIGR03345 480 VEAILALRAELEADADAPADDD-----DALRAQLAELEAALASAQGEEPLVFPEVDAQAVAEVVADWTGIPVGRMVRDEI 554

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  569 SIVTDLPSYLEESIKGQSLAIQCLHKHLLTARADLRRPGRPLGAFLLAGPSGVGKTETVIQIAQLMFGGTQYLTTINMSE 648
Cdd:TIGR03345 555 EAVLSLPDRLAERVIGQDHALEAIAERIRTARAGLEDPRKPLGVFLLVGPSGVGKTETALALAELLYGGEQNLITINMSE 634

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  649 FQEKHTVSRLIGSPPGYVGYGEGGILTEAIRQKPYSVVLLDEVEKAHPDVLNLFYQAFDKGEIADGEGRVIDCKNIAFFL 728
Cdd:TIGR03345 635 FQEAHTVSRLKGSPPGYVGYGEGGVLTEAVRRKPYSVVLLDEVEKAHPDVLELFYQVFDKGVMEDGEGREIDFKNTVILL 714

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  729 TSNLGDHVITA------YADKPDELQDALYPELTTFFKPALLARMEIVPYLPLSADILRQIVDSKLTRLMILLKQRFNAK 802
Cdd:TIGR03345 715 TSNAGSDLIMAlcadpeTAPDPEALLEALRPELLKVFKPAFLGRMTVIPYLPLDDDVLAAIVRLKLDRIARRLKENHGAE 794

                         810       820       830       840       850
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 491046388  803 IQLEESVPNEILRRASRAENGARILESIIDGALLPPLSLLLLQFSARNETISHIRLT 859
Cdd:TIGR03345 795 LVYSEALVEHIVARCTEVESGARNIDAILNQTLLPELSRQILERLAAGEPIERIHLD 851
 
Name Accession Description Interval E-value
VI_ClpV1 TIGR03345
type VI secretion ATPase, ClpV1 family; Members of this protein family are homologs of ClpB, ...
 13-859 0e+00

type VI secretion ATPase, ClpV1 family; Members of this protein family are homologs of ClpB, an ATPase associated with chaperone-related functions. These ClpB homologs, designated ClpV1, are a key component of the bacterial pathogenicity-associated type VI secretion system. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 274528 [Multi-domain]  Cd Length: 852  Bit Score: 1156.62  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388   13 LHPIAKHALESAAAYCVSHQQPEITIAQFLQKLIETPLTDIRLISQKSTLDINKLSELLDIQIPPHQAITQSYPSFSPLL 92
Cdd:TIGR03345   1 LNPTSRRALEQAAALCVARGHPEVELEHWLLALLDQPDSDLAAILRHFGVDLGRLKADLARALDKLPRGNTRTPVFSPHL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388   93 VEWMKDSWLLASTEFNHSELRSGVLFLTLLQMP-LRYLPKPVADMLSQVNREQLKLSFDKWTEGSAESP---FDEQAPQN 168
Cdd:TIGR03345  81 VELLQEAWLLASLELGDGRIRSGHLLLALLTDPeLRRLLGSISPELAKIDREALREALPALVEGSAEASaaaADAAPAGA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  169 NGKIASDSLLAKFTQNMTEQARNNELDPVLCRDHEIDLMIDILCRRRKNNPVVVGEPGVGKSALIEGLALRIIAGEIPEK 248
Cdd:TIGR03345 161 AAGAAGTSALDQYTTDLTAQAREGKIDPVLGRDDEIRQMIDILLRRRQNNPILTGEAGVGKTAVVEGLALRIAAGDVPPA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  249 LRGCELLTLDLGALQAGAAVKGEFEKRFKGIMQEVSQSPHPIILFIDEAHTLIGAGNQQGGLDVSNLLKPALARGELRTI 328
Cdd:TIGR03345 241 LRNVRLLSLDLGLLQAGASVKGEFENRLKSVIDEVKASPQPIILFIDEAHTLIGAGGQAGQGDAANLLKPALARGELRTI 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  329 AATTWSEYKKYFEKDAALARRFQLVQVKEPTSADAIIIMRGLRAIYEKAHNVFIDDEALRASAELSERYISGRQLPDKAI 408
Cdd:TIGR03345 321 AATTWAEYKKYFEKDPALTRRFQVVKVEEPDEETAIRMLRGLAPVLEKHHGVLILDEAVVAAVELSHRYIPGRQLPDKAV 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  409 DVLDTACARAAINLSSPPKMLSSLKTDLQQIEMETAILKREHHLGLDnHSERLEELASKANEIEQKASDIQQAWEQQQAL 488
Cdd:TIGR03345 401 SLLDTACARVALSQNATPAALEDLRRRIAALELELDALEREAALGAD-HDERLAELRAELAALEAELAALEARWQQEKEL 479

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  489 VSQIITLRSTLLDDENTEPQPEetcqvDELKQELQTLDQQLAQLHETHLLVSPHVDKKQIAAVIAEWTGVPLNRLSQDAL 568
Cdd:TIGR03345 480 VEAILALRAELEADADAPADDD-----DALRAQLAELEAALASAQGEEPLVFPEVDAQAVAEVVADWTGIPVGRMVRDEI 554

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  569 SIVTDLPSYLEESIKGQSLAIQCLHKHLLTARADLRRPGRPLGAFLLAGPSGVGKTETVIQIAQLMFGGTQYLTTINMSE 648
Cdd:TIGR03345 555 EAVLSLPDRLAERVIGQDHALEAIAERIRTARAGLEDPRKPLGVFLLVGPSGVGKTETALALAELLYGGEQNLITINMSE 634

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  649 FQEKHTVSRLIGSPPGYVGYGEGGILTEAIRQKPYSVVLLDEVEKAHPDVLNLFYQAFDKGEIADGEGRVIDCKNIAFFL 728
Cdd:TIGR03345 635 FQEAHTVSRLKGSPPGYVGYGEGGVLTEAVRRKPYSVVLLDEVEKAHPDVLELFYQVFDKGVMEDGEGREIDFKNTVILL 714

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  729 TSNLGDHVITA------YADKPDELQDALYPELTTFFKPALLARMEIVPYLPLSADILRQIVDSKLTRLMILLKQRFNAK 802
Cdd:TIGR03345 715 TSNAGSDLIMAlcadpeTAPDPEALLEALRPELLKVFKPAFLGRMTVIPYLPLDDDVLAAIVRLKLDRIARRLKENHGAE 794

                         810       820       830       840       850
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 491046388  803 IQLEESVPNEILRRASRAENGARILESIIDGALLPPLSLLLLQFSARNETISHIRLT 859
Cdd:TIGR03345 795 LVYSEALVEHIVARCTEVESGARNIDAILNQTLLPELSRQILERLAAGEPIERIHLD 851
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
 11-831 0e+00

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 967.63  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  11 NRLHPIAKHALESAAAYCVSHQQPEITIAQFLQKLIETPLTDIRLISQKSTLDINKLSELLDIQIP--PHQAITQSYPSF 88
Cdd:COG0542    4 EKFTEKAQEALEAAQELARRLGHQEVEPEHLLLALLEQGEGLAAKLLRKLGVDLDALREELEEALGrlPKVSGSSGQPYL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  89 SPLLVEWMKDSWLLAStEFNHSELRSGVLFLTLLQMPLRylpkPVADMLSQ--VNREQLKLSFDKWTEGSAEspfDEQAP 166
Cdd:COG0542   84 SPRLKRVLELAELEAR-KLGDEYISTEHLLLALLREGEG----VAARILKKlgITLEALREALEELRGGSRV---TSQNP 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 167 QNNGkiasdSLLAKFTQNMTEQARNNELDPVLCRDHEIDLMIDILCRRRKNNPVVVGEPGVGKSALIEGLALRIIAGEIP 246
Cdd:COG0542  156 ESKT-----PALDKYGRDLTELAREGKLDPVIGRDEEIRRVIQILSRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGDVP 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 247 EKLRGCELLTLDLGALQAGAAVKGEFEKRFKGIMQEVSQSPHPIILFIDEAHTLIGAGNQQGGLDVSNLLKPALARGELR 326
Cdd:COG0542  231 ESLKDKRVLSLDLGALVAGAKYRGEFEERLKAVLDEVKKSEGNIILFIDELHTLVGAGGAEGAMDAANLLKPALARGELR 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 327 TIAATTWSEYKKYFEKDAALARRFQLVQVKEPTSADAIIIMRGLRAIYEKAHNVFIDDEALRASAELSERYISGRQLPDK 406
Cdd:COG0542  311 CIGATTLDEYRKYIEKDAALERRFQPVLVEEPSVEDTISILRGLKERYEAHHGVRITDEALVAAVRLSDRYITDRFLPDK 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 407 AIDVLDTACARAAINLSSPPKMLSSLKTDLQQIEMETAILKREHHLGldnHSERLEELASKANEIEQKASDIQQAWEQQQ 486
Cdd:COG0542  391 AIDLIDEAAARVRMEIDSKPEELDELERRLEQLEIEKEALKKEQDEA---SFERLAELRDELAELEEELEALKARWEAEK 467

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 487 ALVSQIITLRSTLLDDENTEPqpeetcqvdELKQELQTLDQQLAQLHEthlLVSPHVDKKQIAAVIAEWTGVPLNRLSQD 566
Cdd:COG0542  468 ELIEEIQELKEELEQRYGKIP---------ELEKELAELEEELAELAP---LLREEVTEEDIAEVVSRWTGIPVGKLLEG 535

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 567 ALSIVTDLPSYLEESIKGQSLAIQCLHKHLLTARADLRRPGRPLGAFLLAGPSGVGKTETVIQIAQLMFGGTQYLTTINM 646
Cdd:COG0542  536 EREKLLNLEEELHERVIGQDEAVEAVADAIRRSRAGLKDPNRPIGSFLFLGPTGVGKTELAKALAEFLFGDEDALIRIDM 615

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 647 SEFQEKHTVSRLIGSPPGYVGYGEGGILTEAIRQKPYSVVLLDEVEKAHPDVLNLFYQAFDKGEIADGEGRVIDCKNIAF 726
Cdd:COG0542  616 SEYMEKHSVSRLIGAPPGYVGYEEGGQLTEAVRRRPYSVVLLDEIEKAHPDVFNILLQVLDDGRLTDGQGRTVDFRNTII 695

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 727 FLTSNLGDHVITAYADK---PDELQDALYPELTTFFKPALLARM-EIVPYLPLSADILRQIVDSKLTRLMILLKQRfNAK 802
Cdd:COG0542  696 IMTSNIGSELILDLAEDepdYEEMKEAVMEELKKHFRPEFLNRIdEIIVFHPLSKEELRKIVDLQLKRLRKRLAER-GIT 774

                        810       820
                 ....*....|....*....|....*....
gi 491046388 803 IQLEESVPNEILRRASRAENGARILESII 831
Cdd:COG0542  775 LELTDAAKDFLAEKGYDPEYGARPLKRAI 803
clpC CHL00095
Clp protease ATP binding subunit
 178-831 0e+00

Clp protease ATP binding subunit


Pssm-ID: 214361 [Multi-domain]  Cd Length: 821  Bit Score: 546.58  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 178 LAKFTQNMTEQARNNELDPVLCRDHEIDLMIDILCRRRKNNPVVVGEPGVGKSALIEGLALRIIAGEIPEKLRGCELLTL 257
Cdd:CHL00095 162 LEEFGTNLTKEAIDGNLDPVIGREKEIERVIQILGRRTKNNPILIGEPGVGKTAIAEGLAQRIVNRDVPDILEDKLVITL 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 258 DLGALQAGAAVKGEFEKRFKGIMQEVsQSPHPIILFIDEAHTLIGAGNQQGGLDVSNLLKPALARGELRTIAATTWSEYK 337
Cdd:CHL00095 242 DIGLLLAGTKYRGEFEERLKRIFDEI-QENNNIILVIDEVHTLIGAGAAEGAIDAANILKPALARGELQCIGATTLDEYR 320

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 338 KYFEKDAALARRFQLVQVKEPTSADAIIIMRGLRAIYEKAHNVFIDDEALRASAELSERYISGRQLPDKAIDVLDTACAR 417
Cdd:CHL00095 321 KHIEKDPALERRFQPVYVGEPSVEETIEILFGLRSRYEKHHNLSISDKALEAAAKLSDQYIADRFLPDKAIDLLDEAGSR 400

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 418 AAINLSSPPKMLSSLKTDLQQIEMETAILKREHHLgldnhsERLEELASKANEIEqkasdiqqaweqqqalvSQIITLRS 497
Cdd:CHL00095 401 VRLINSRLPPAARELDKELREILKDKDEAIREQDF------ETAKQLRDREMEVR-----------------AQIAAIIQ 457

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 498 TLLDDENTEPQPeetcqvdelkqelqtldqqlaqlhethllvsPHVDKKQIAAVIAEWTGVPLNRLSQDALSIVTDLPSY 577
Cdd:CHL00095 458 SKKTEEEKRLEV-------------------------------PVVTEEDIAEIVSAWTGIPVNKLTKSESEKLLHMEET 506

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 578 LEESIKGQSLAIQCLHKHLLTARADLRRPGRPLGAFLLAGPSGVGKTETVIQIAQLMFGGTQYLTTINMSEFQEKHTVSR 657
Cdd:CHL00095 507 LHKRIIGQDEAVVAVSKAIRRARVGLKNPNRPIASFLFSGPTGVGKTELTKALASYFFGSEDAMIRLDMSEYMEKHTVSK 586

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 658 LIGSPPGYVGYGEGGILTEAIRQKPYSVVLLDEVEKAHPDVLNLFYQAFDKGEIADGEGRVIDCKNIAFFLTSNLGDHVI 737
Cdd:CHL00095 587 LIGSPPGYVGYNEGGQLTEAVRKKPYTVVLFDEIEKAHPDIFNLLLQILDDGRLTDSKGRTIDFKNTLIIMTSNLGSKVI 666

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 738 TA------YADKPDELQDALYP--------ELTTFFKPALLARM-EIVPYLPLSADILRQIVDskltrlmILLKQRF--- 799
Cdd:CHL00095 667 ETnsgglgFELSENQLSEKQYKrlsnlvneELKQFFRPEFLNRLdEIIVFRQLTKNDVWEIAE-------IMLKNLFkrl 739

                        650       660       670
                 ....*....|....*....|....*....|....*
gi 491046388 800 -NAKIQLE--ESVPNEILRRASRAENGARILESII 831
Cdd:CHL00095 740 nEQGIQLEvtERIKTLLIEEGYNPLYGARPLRRAI 774
RecA-like_ClpB_Hsp104-like cd19499
Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and ...
 571-772 1.57e-80

Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and eukaryotic Heat shock protein 104 (Hsp104) are ATP-dependent molecular chaperones and essential proteins of the heat-shock response. ClpB/Hsp104 ATPases, in concert with the DnaK/Hsp70 chaperone system, disaggregate and reactivate aggregated proteins. This RecA-like_ClpB_Hsp104_like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410907 [Multi-domain]  Cd Length: 178  Bit Score: 257.11  E-value: 1.57e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 571 VTDLPSYLEESIKGQSLAIQCLHKHLLTARADLRRPGRPLGAFLLAGPSGVGKTETVIQIAQLMFGGTQYLTTINMSEFQ 650
Cdd:cd19499    2 LLNLEERLHERVVGQDEAVKAVSDAIRRARAGLSDPNRPIGSFLFLGPTGVGKTELAKALAELLFGDEDNLIRIDMSEYM 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 651 EKHTVSRLIGSPPGYVGYGEGGILTEAIRQKPYSVVLLDEVEKAHPDVLNLFYQAFDKGEIADGEGRVIDCKNIAFFLTS 730
Cdd:cd19499   82 EKHSVSRLIGAPPGYVGYTEGGQLTEAVRRKPYSVVLLDEIEKAHPDVQNLLLQVLDDGRLTDSHGRTVDFKNTIIIMTS 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 491046388 731 NlgdhvitayadkpdelqdalypelttFFKPALLARMEIVPY 772
Cdd:cd19499  162 N--------------------------HFRPEFLNRIDEIVV 177
AAA_2 pfam07724
AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected ...
 608-770 1.84e-66

AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400187 [Multi-domain]  Cd Length: 168  Bit Score: 218.99  E-value: 1.84e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  608 RPLGAFLLAGPSGVGKTETVIQIAQLMFGGTQYLTTINMSEFQEKHTVSRLIGSPPGYVGYGEGGILTEAIRQKPYSVVL 687
Cdd:pfam07724   1 RPIGSFLFLGPTGVGKTELAKALAELLFGDERALIRIDMSEYMEEHSVSRLIGAPPGYVGYEEGGQLTEAVRRKPYSIVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  688 LDEVEKAHPDVLNLFYQAFDKGEIADGEGRVIDCKNIAFFLTSNLG-----DHVITAYADKPDELQDALYPELTTFFKPA 762
Cdd:pfam07724  81 IDEIEKAHPGVQNDLLQILEGGTLTDKQGRTVDFKNTLFIMTGNFGsekisDASRLGDSPDYELLKEEVMDLLKKGFIPE 160


                  ....*...
gi 491046388  763 LLARMEIV 770
Cdd:pfam07724 161 FLGRLPII 168
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 614-739 3.07e-09

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 56.61  E-value: 3.07e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388   614 LLAGPSGVGKTETVIQIAQLMFGGTQYLTTINMSEFQEKHTVSRLIGSPPGYVGYGEGG----ILTEAIRQKPYSVVLLD 689
Cdd:smart00382   6 LIVGPPGSGKTTLARALARELGPPGGGVIYIDGEDILEEVLDQLLLIIVGGKKASGSGElrlrLALALARKLKPDVLILD 85

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 491046388   690 EVEKAHPDVLNLFYQAFDKGEIADGEGRvidCKNIAFFLTSNLGDHVITA 739
Cdd:smart00382  86 EITSLLDAEQEALLLLLEELRLLLLLKS---EKNLTVILTTNDEKDLGPA 132
 
Name Accession Description Interval E-value
VI_ClpV1 TIGR03345
type VI secretion ATPase, ClpV1 family; Members of this protein family are homologs of ClpB, ...
 13-859 0e+00

type VI secretion ATPase, ClpV1 family; Members of this protein family are homologs of ClpB, an ATPase associated with chaperone-related functions. These ClpB homologs, designated ClpV1, are a key component of the bacterial pathogenicity-associated type VI secretion system. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 274528 [Multi-domain]  Cd Length: 852  Bit Score: 1156.62  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388   13 LHPIAKHALESAAAYCVSHQQPEITIAQFLQKLIETPLTDIRLISQKSTLDINKLSELLDIQIPPHQAITQSYPSFSPLL 92
Cdd:TIGR03345   1 LNPTSRRALEQAAALCVARGHPEVELEHWLLALLDQPDSDLAAILRHFGVDLGRLKADLARALDKLPRGNTRTPVFSPHL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388   93 VEWMKDSWLLASTEFNHSELRSGVLFLTLLQMP-LRYLPKPVADMLSQVNREQLKLSFDKWTEGSAESP---FDEQAPQN 168
Cdd:TIGR03345  81 VELLQEAWLLASLELGDGRIRSGHLLLALLTDPeLRRLLGSISPELAKIDREALREALPALVEGSAEASaaaADAAPAGA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  169 NGKIASDSLLAKFTQNMTEQARNNELDPVLCRDHEIDLMIDILCRRRKNNPVVVGEPGVGKSALIEGLALRIIAGEIPEK 248
Cdd:TIGR03345 161 AAGAAGTSALDQYTTDLTAQAREGKIDPVLGRDDEIRQMIDILLRRRQNNPILTGEAGVGKTAVVEGLALRIAAGDVPPA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  249 LRGCELLTLDLGALQAGAAVKGEFEKRFKGIMQEVSQSPHPIILFIDEAHTLIGAGNQQGGLDVSNLLKPALARGELRTI 328
Cdd:TIGR03345 241 LRNVRLLSLDLGLLQAGASVKGEFENRLKSVIDEVKASPQPIILFIDEAHTLIGAGGQAGQGDAANLLKPALARGELRTI 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  329 AATTWSEYKKYFEKDAALARRFQLVQVKEPTSADAIIIMRGLRAIYEKAHNVFIDDEALRASAELSERYISGRQLPDKAI 408
Cdd:TIGR03345 321 AATTWAEYKKYFEKDPALTRRFQVVKVEEPDEETAIRMLRGLAPVLEKHHGVLILDEAVVAAVELSHRYIPGRQLPDKAV 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  409 DVLDTACARAAINLSSPPKMLSSLKTDLQQIEMETAILKREHHLGLDnHSERLEELASKANEIEQKASDIQQAWEQQQAL 488
Cdd:TIGR03345 401 SLLDTACARVALSQNATPAALEDLRRRIAALELELDALEREAALGAD-HDERLAELRAELAALEAELAALEARWQQEKEL 479

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  489 VSQIITLRSTLLDDENTEPQPEetcqvDELKQELQTLDQQLAQLHETHLLVSPHVDKKQIAAVIAEWTGVPLNRLSQDAL 568
Cdd:TIGR03345 480 VEAILALRAELEADADAPADDD-----DALRAQLAELEAALASAQGEEPLVFPEVDAQAVAEVVADWTGIPVGRMVRDEI 554

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  569 SIVTDLPSYLEESIKGQSLAIQCLHKHLLTARADLRRPGRPLGAFLLAGPSGVGKTETVIQIAQLMFGGTQYLTTINMSE 648
Cdd:TIGR03345 555 EAVLSLPDRLAERVIGQDHALEAIAERIRTARAGLEDPRKPLGVFLLVGPSGVGKTETALALAELLYGGEQNLITINMSE 634

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  649 FQEKHTVSRLIGSPPGYVGYGEGGILTEAIRQKPYSVVLLDEVEKAHPDVLNLFYQAFDKGEIADGEGRVIDCKNIAFFL 728
Cdd:TIGR03345 635 FQEAHTVSRLKGSPPGYVGYGEGGVLTEAVRRKPYSVVLLDEVEKAHPDVLELFYQVFDKGVMEDGEGREIDFKNTVILL 714

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  729 TSNLGDHVITA------YADKPDELQDALYPELTTFFKPALLARMEIVPYLPLSADILRQIVDSKLTRLMILLKQRFNAK 802
Cdd:TIGR03345 715 TSNAGSDLIMAlcadpeTAPDPEALLEALRPELLKVFKPAFLGRMTVIPYLPLDDDVLAAIVRLKLDRIARRLKENHGAE 794

                         810       820       830       840       850
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 491046388  803 IQLEESVPNEILRRASRAENGARILESIIDGALLPPLSLLLLQFSARNETISHIRLT 859
Cdd:TIGR03345 795 LVYSEALVEHIVARCTEVESGARNIDAILNQTLLPELSRQILERLAAGEPIERIHLD 851
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
 11-831 0e+00

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 967.63  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  11 NRLHPIAKHALESAAAYCVSHQQPEITIAQFLQKLIETPLTDIRLISQKSTLDINKLSELLDIQIP--PHQAITQSYPSF 88
Cdd:COG0542    4 EKFTEKAQEALEAAQELARRLGHQEVEPEHLLLALLEQGEGLAAKLLRKLGVDLDALREELEEALGrlPKVSGSSGQPYL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  89 SPLLVEWMKDSWLLAStEFNHSELRSGVLFLTLLQMPLRylpkPVADMLSQ--VNREQLKLSFDKWTEGSAEspfDEQAP 166
Cdd:COG0542   84 SPRLKRVLELAELEAR-KLGDEYISTEHLLLALLREGEG----VAARILKKlgITLEALREALEELRGGSRV---TSQNP 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 167 QNNGkiasdSLLAKFTQNMTEQARNNELDPVLCRDHEIDLMIDILCRRRKNNPVVVGEPGVGKSALIEGLALRIIAGEIP 246
Cdd:COG0542  156 ESKT-----PALDKYGRDLTELAREGKLDPVIGRDEEIRRVIQILSRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGDVP 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 247 EKLRGCELLTLDLGALQAGAAVKGEFEKRFKGIMQEVSQSPHPIILFIDEAHTLIGAGNQQGGLDVSNLLKPALARGELR 326
Cdd:COG0542  231 ESLKDKRVLSLDLGALVAGAKYRGEFEERLKAVLDEVKKSEGNIILFIDELHTLVGAGGAEGAMDAANLLKPALARGELR 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 327 TIAATTWSEYKKYFEKDAALARRFQLVQVKEPTSADAIIIMRGLRAIYEKAHNVFIDDEALRASAELSERYISGRQLPDK 406
Cdd:COG0542  311 CIGATTLDEYRKYIEKDAALERRFQPVLVEEPSVEDTISILRGLKERYEAHHGVRITDEALVAAVRLSDRYITDRFLPDK 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 407 AIDVLDTACARAAINLSSPPKMLSSLKTDLQQIEMETAILKREHHLGldnHSERLEELASKANEIEQKASDIQQAWEQQQ 486
Cdd:COG0542  391 AIDLIDEAAARVRMEIDSKPEELDELERRLEQLEIEKEALKKEQDEA---SFERLAELRDELAELEEELEALKARWEAEK 467

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 487 ALVSQIITLRSTLLDDENTEPqpeetcqvdELKQELQTLDQQLAQLHEthlLVSPHVDKKQIAAVIAEWTGVPLNRLSQD 566
Cdd:COG0542  468 ELIEEIQELKEELEQRYGKIP---------ELEKELAELEEELAELAP---LLREEVTEEDIAEVVSRWTGIPVGKLLEG 535

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 567 ALSIVTDLPSYLEESIKGQSLAIQCLHKHLLTARADLRRPGRPLGAFLLAGPSGVGKTETVIQIAQLMFGGTQYLTTINM 646
Cdd:COG0542  536 EREKLLNLEEELHERVIGQDEAVEAVADAIRRSRAGLKDPNRPIGSFLFLGPTGVGKTELAKALAEFLFGDEDALIRIDM 615

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 647 SEFQEKHTVSRLIGSPPGYVGYGEGGILTEAIRQKPYSVVLLDEVEKAHPDVLNLFYQAFDKGEIADGEGRVIDCKNIAF 726
Cdd:COG0542  616 SEYMEKHSVSRLIGAPPGYVGYEEGGQLTEAVRRRPYSVVLLDEIEKAHPDVFNILLQVLDDGRLTDGQGRTVDFRNTII 695

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 727 FLTSNLGDHVITAYADK---PDELQDALYPELTTFFKPALLARM-EIVPYLPLSADILRQIVDSKLTRLMILLKQRfNAK 802
Cdd:COG0542  696 IMTSNIGSELILDLAEDepdYEEMKEAVMEELKKHFRPEFLNRIdEIIVFHPLSKEELRKIVDLQLKRLRKRLAER-GIT 774

                        810       820
                 ....*....|....*....|....*....
gi 491046388 803 IQLEESVPNEILRRASRAENGARILESII 831
Cdd:COG0542  775 LELTDAAKDFLAEKGYDPEYGARPLKRAI 803
chaperone_ClpB TIGR03346
ATP-dependent chaperone ClpB; Members of this protein family are the bacterial ATP-dependent ...
 178-806 0e+00

ATP-dependent chaperone ClpB; Members of this protein family are the bacterial ATP-dependent chaperone ClpB. This protein belongs to the AAA family, ATPases associated with various cellular activities (pfam00004). This molecular chaperone does not act as a protease, but rather serves to disaggregate misfolded and aggregated proteins. [Protein fate, Protein folding and stabilization]


Pssm-ID: 274529 [Multi-domain]  Cd Length: 850  Bit Score: 635.84  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  178 LAKFTQNMTEQARNNELDPVLCRDHEIDLMIDILCRRRKNNPVVVGEPGVGKSALIEGLALRIIAGEIPEKLRGCELLTL 257
Cdd:TIGR03346 156 LEKYARDLTERAREGKLDPVIGRDEEIRRTIQVLSRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGDVPEGLKNKRLLAL 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  258 DLGALQAGAAVKGEFEKRFKGIMQEVSQSPHPIILFIDEAHTLIGAGNQQGGLDVSNLLKPALARGELRTIAATTWSEYK 337
Cdd:TIGR03346 236 DMGALIAGAKYRGEFEERLKAVLNEVTKSEGQIILFIDELHTLVGAGKAEGAMDAGNMLKPALARGELHCIGATTLDEYR 315

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  338 KYFEKDAALARRFQLVQVKEPTSADAIIIMRGLRAIYEKAHNVFIDDEALRASAELSERYISGRQLPDKAIDVLDTACAR 417
Cdd:TIGR03346 316 KYIEKDAALERRFQPVFVDEPSVEDTISILRGLKERYEVHHGVRITDPAIVAAATLSHRYITDRFLPDKAIDLIDEAAAR 395

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  418 AAINLSSPPKMLSSLKTDLQQIEMETAILKREHhlglDNHS-ERLEELASKANEIEQKASDIQQAWEQQQALVSQIITLR 496
Cdd:TIGR03346 396 IRMEIDSKPEELDELDRRIIQLEIEREALKKEK----DEASkKRLEDLEKELADLEEEYAELEEQWKAEKASIQGIQQIK 471

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  497 STL----LDDENTEPQPE-------ETCQVDELKQELQTLDQQLAqlHETHLLVSPHVDKKQIAAVIAEWTGVPLNRLSQ 565
Cdd:TIGR03346 472 EEIeqvrLELEQAEREGDlakaaelQYGKLPELEKQLQAAEQKLG--EEQNRLLREEVTAEEIAEVVSRWTGIPVSKMLE 549

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  566 DALSIVTDLPSYLEESIKGQSLAIQCLHKHLLTARADLRRPGRPLGAFLLAGPSGVGKTETVIQIAQLMFGGTQYLTTIN 645
Cdd:TIGR03346 550 GEREKLLHMEEELHERVVGQDEAVEAVSDAIRRSRAGLSDPNRPIGSFLFLGPTGVGKTELAKALAEFLFDSEDAMVRID 629

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  646 MSEFQEKHTVSRLIGSPPGYVGYGEGGILTEAIRQKPYSVVLLDEVEKAHPDVLNLFYQAFDKGEIADGEGRVIDCKNIA 725
Cdd:TIGR03346 630 MSEYMEKHSVARLIGAPPGYVGYEEGGQLTEAVRRRPYSVVLFDEVEKAHPDVFNVLLQVLDDGRLTDGQGRTVDFRNTV 709

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  726 FFLTSNLGDHVITAYADKPD--ELQDALYPELTTFFKPALLARM-EIVPYLPLSADILRQIVDSKLTRLMILLKQRfnaK 802
Cdd:TIGR03346 710 IIMTSNLGSDFIQELAGGDDyeEMREAVMEVLRAHFRPEFLNRIdEIVVFHPLGREQIARIVEIQLGRLRKRLAER---K 786


                  ....
gi 491046388  803 IQLE 806
Cdd:TIGR03346 787 ITLE 790
clpC CHL00095
Clp protease ATP binding subunit
 178-831 0e+00

Clp protease ATP binding subunit


Pssm-ID: 214361 [Multi-domain]  Cd Length: 821  Bit Score: 546.58  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 178 LAKFTQNMTEQARNNELDPVLCRDHEIDLMIDILCRRRKNNPVVVGEPGVGKSALIEGLALRIIAGEIPEKLRGCELLTL 257
Cdd:CHL00095 162 LEEFGTNLTKEAIDGNLDPVIGREKEIERVIQILGRRTKNNPILIGEPGVGKTAIAEGLAQRIVNRDVPDILEDKLVITL 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 258 DLGALQAGAAVKGEFEKRFKGIMQEVsQSPHPIILFIDEAHTLIGAGNQQGGLDVSNLLKPALARGELRTIAATTWSEYK 337
Cdd:CHL00095 242 DIGLLLAGTKYRGEFEERLKRIFDEI-QENNNIILVIDEVHTLIGAGAAEGAIDAANILKPALARGELQCIGATTLDEYR 320

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 338 KYFEKDAALARRFQLVQVKEPTSADAIIIMRGLRAIYEKAHNVFIDDEALRASAELSERYISGRQLPDKAIDVLDTACAR 417
Cdd:CHL00095 321 KHIEKDPALERRFQPVYVGEPSVEETIEILFGLRSRYEKHHNLSISDKALEAAAKLSDQYIADRFLPDKAIDLLDEAGSR 400

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 418 AAINLSSPPKMLSSLKTDLQQIEMETAILKREHHLgldnhsERLEELASKANEIEqkasdiqqaweqqqalvSQIITLRS 497
Cdd:CHL00095 401 VRLINSRLPPAARELDKELREILKDKDEAIREQDF------ETAKQLRDREMEVR-----------------AQIAAIIQ 457

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 498 TLLDDENTEPQPeetcqvdelkqelqtldqqlaqlhethllvsPHVDKKQIAAVIAEWTGVPLNRLSQDALSIVTDLPSY 577
Cdd:CHL00095 458 SKKTEEEKRLEV-------------------------------PVVTEEDIAEIVSAWTGIPVNKLTKSESEKLLHMEET 506

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 578 LEESIKGQSLAIQCLHKHLLTARADLRRPGRPLGAFLLAGPSGVGKTETVIQIAQLMFGGTQYLTTINMSEFQEKHTVSR 657
Cdd:CHL00095 507 LHKRIIGQDEAVVAVSKAIRRARVGLKNPNRPIASFLFSGPTGVGKTELTKALASYFFGSEDAMIRLDMSEYMEKHTVSK 586

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 658 LIGSPPGYVGYGEGGILTEAIRQKPYSVVLLDEVEKAHPDVLNLFYQAFDKGEIADGEGRVIDCKNIAFFLTSNLGDHVI 737
Cdd:CHL00095 587 LIGSPPGYVGYNEGGQLTEAVRKKPYTVVLFDEIEKAHPDIFNLLLQILDDGRLTDSKGRTIDFKNTLIIMTSNLGSKVI 666

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 738 TA------YADKPDELQDALYP--------ELTTFFKPALLARM-EIVPYLPLSADILRQIVDskltrlmILLKQRF--- 799
Cdd:CHL00095 667 ETnsgglgFELSENQLSEKQYKrlsnlvneELKQFFRPEFLNRLdEIIVFRQLTKNDVWEIAE-------IMLKNLFkrl 739

                        650       660       670
                 ....*....|....*....|....*....|....*
gi 491046388 800 -NAKIQLE--ESVPNEILRRASRAENGARILESII 831
Cdd:CHL00095 740 nEQGIQLEvtERIKTLLIEEGYNPLYGARPLRRAI 774
PRK10865 PRK10865
ATP-dependent chaperone ClpB;
178-798 2.25e-177

ATP-dependent chaperone ClpB;


Pssm-ID: 182791 [Multi-domain]  Cd Length: 857  Bit Score: 534.04  E-value: 2.25e-177
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 178 LAKFTQNMTEQARNNELDPVLCRDHEIDLMIDILCRRRKNNPVVVGEPGVGKSALIEGLALRIIAGEIPEKLRGCELLTL 257
Cdd:PRK10865 161 LKKYTIDLTERAEQGKLDPVIGRDEEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPEGLKGRRVLAL 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 258 DLGALQAGAAVKGEFEKRFKGIMQEVSQSPHPIILFIDEAHTLIGAGNQQGGLDVSNLLKPALARGELRTIAATTWSEYK 337
Cdd:PRK10865 241 DMGALVAGAKYRGEFEERLKGVLNDLAKQEGNVILFIDELHTMVGAGKADGAMDAGNMLKPALARGELHCVGATTLDEYR 320

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 338 KYFEKDAALARRFQLVQVKEPTSADAIIIMRGLRAIYEKAHNVFIDDEALRASAELSERYISGRQLPDKAIDVLDTACAR 417
Cdd:PRK10865 321 QYIEKDAALERRFQKVFVAEPSVEDTIAILRGLKERYELHHHVQITDPAIVAAATLSHRYIADRQLPDKAIDLIDEAASS 400

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 418 AAINLSSPPKMLSSLKTDLQQIEMETAILKREHHlglDNHSERLEELASKANEIEQKASDIQQAWEQQQALVSQIITLRS 497
Cdd:PRK10865 401 IRMQIDSKPEELDRLDRRIIQLKLEQQALMKESD---EASKKRLDMLNEELSDKERQYSELEEEWKAEKASLSGTQTIKA 477

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 498 TLlddENTEPQPEETCQVDELKQ--ELQ-----TLDQQLA---QLHETHL-LVSPHVDKKQIAAVIAEWTGVPLNRLSQD 566
Cdd:PRK10865 478 EL---EQAKIAIEQARRVGDLARmsELQygkipELEKQLAaatQLEGKTMrLLRNKVTDAEIAEVLARWTGIPVSRMLES 554

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 567 ALSIVTDLPSYLEESIKGQSLAIQCLHKHLLTARADLRRPGRPLGAFLLAGPSGVGKTETVIQIAQLMFGGTQYLTTINM 646
Cdd:PRK10865 555 EREKLLRMEQELHHRVIGQNEAVEAVSNAIRRSRAGLSDPNRPIGSFLFLGPTGVGKTELCKALANFMFDSDDAMVRIDM 634

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 647 SEFQEKHTVSRLIGSPPGYVGYGEGGILTEAIRQKPYSVVLLDEVEKAHPDVLNLFYQAFDKGEIADGEGRVIDCKNIAF 726
Cdd:PRK10865 635 SEFMEKHSVSRLVGAPPGYVGYEEGGYLTEAVRRRPYSVILLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFRNTVV 714

                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491046388 727 FLTSNLGDHVITAYADKPD--ELQDALYPELTTFFKPALLARM-EIVPYLPLSADILRQIVDSKLTRLMILLKQR 798
Cdd:PRK10865 715 IMTSNLGSDLIQERFGELDyaHMKELVLGVVSHNFRPEFINRIdEVVVFHPLGEQHIASIAQIQLQRLYKRLEER 789
ClpA TIGR02639
ATP-dependent Clp protease ATP-binding subunit clpA; [Protein fate, Degradation of proteins, ...
 154-832 8.27e-173

ATP-dependent Clp protease ATP-binding subunit clpA; [Protein fate, Degradation of proteins, peptides, and glycopeptides]


Pssm-ID: 274241 [Multi-domain]  Cd Length: 730  Bit Score: 518.04  E-value: 8.27e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  154 EGSAESPFDEQAPQNNGKIAsdslLAKFTQNMTEQARNNELDPVLCRDHEIDLMIDILCRRRKNNPVVVGEPGVGKSALI 233
Cdd:TIGR02639 144 DGKDQLGEEAGKEEEKGQDA----LEKYTVDLTEKAKNGKIDPLIGREDELERTIQVLCRRKKNNPLLVGEPGVGKTAIV 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  234 EGLALRIIAGEIPEKLRGCELLTLDLGALQAGAAVKGEFEKRFKGIMQEVSQSPHPiILFIDEAHTLIGAGNQQGG-LDV 312
Cdd:TIGR02639 220 EGLALRIAEGKVPERLKNAKIYSLDMGTLLAGTKYRGDFEERLKAVVSEIEKEPNA-ILFIDEIHTIVGAGATSGGsMDA 298

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  313 SNLLKPALARGELRTIAATTWSEYKKYFEKDAALARRFQLVQVKEPTSADAIIIMRGLRAIYEKAHNVFIDDEALRASAE 392
Cdd:TIGR02639 299 SNLLKPALSSGKIRCIGSTTYEEYKNHFEKDRALSRRFQKIDVGEPSIEETVKILKGLKEQYEEFHHVKYSDEALEAAVE 378

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  393 LSERYISGRQLPDKAIDVLDTACARAAINLSSPPKMLsslktdlqqiemetailkrehhlgldnhserleelaskaneie 472
Cdd:TIGR02639 379 LSARYINDRFLPDKAIDVIDEAGAAFRLRPKAKKKAN------------------------------------------- 415

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  473 qkasdiqqaweqqqalvsqiitlrstllddentepqpeetcqvdelkqelqtldqqlaqlhethllvsphVDKKQIAAVI 552
Cdd:TIGR02639 416 ----------------------------------------------------------------------VNVKDIENVV 425

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  553 AEWTGVPLNRLSQDALSIVTDLPSYLEESIKGQSLAIQCLHKHLLTARADLRRPGRPLGAFLLAGPSGVGKTETVIQIAQ 632
Cdd:TIGR02639 426 AKMAKIPVKTVSSDDREQLKNLEKNLKAKIFGQDEAIDQLVSAIKRSRAGLGDPNKPVGSFLFVGPTGVGKTELAKQLAE 505

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  633 LMfgGTQYLtTINMSEFQEKHTVSRLIGSPPGYVGYGEGGILTEAIRQKPYSVVLLDEVEKAHPDVLNLFYQAFDKGEIA 712
Cdd:TIGR02639 506 EL--GVHLL-RFDMSEYMEKHTVSRLIGSPPGYVGFEQGGLLTDAVRKHPHCVLLLDEIEKAHPDIYNILLQVMDYATLT 582

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  713 DGEGRVIDCKNIAFFLTSNLGdhviTAYADKP------DELQDALYPELTTFFKPALLARME-IVPYLPLSADILRQIVD 785
Cdd:TIGR02639 583 DNNGRKADFRNVILIMTSNAG----ASEMSKPpigfggENRESKSLKAIKKLFSPEFRNRLDaIIHFNDLSEEMAEKIVK 658

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*..
gi 491046388  786 SKLTRLMILLKQRfNAKIQLEESVPNEILRRASRAENGARILESIID 832
Cdd:TIGR02639 659 KFLDELQDQLNEK-NIELELTDDAKKYLAEKGYDEEFGARPLARVIQ 704
clpA PRK11034
ATP-dependent Clp protease ATP-binding subunit; Provisional
 154-798 3.60e-133

ATP-dependent Clp protease ATP-binding subunit; Provisional


Pssm-ID: 236828 [Multi-domain]  Cd Length: 758  Bit Score: 416.16  E-value: 3.60e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 154 EGSAESPFDEQaPQNNGKIASDSLLAKFTQNMTEQARNNELDPVLCRDHEIDLMIDILCRRRKNNPVVVGEPGVGKSALI 233
Cdd:PRK11034 146 EPSQSSDPGSQ-PNSEEQAGGEERMENFTTNLNQLARVGGIDPLIGREKELERAIQVLCRRRKNNPLLVGESGVGKTAIA 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 234 EGLALRIIAGEIPEKLRGCELLTLDLGALQAGAAVKGEFEKRFKGIMQEVSQSPHPiILFIDEAHTLIGAGNQQGG-LDV 312
Cdd:PRK11034 225 EGLAWRIVQGDVPEVMADCTIYSLDIGSLLAGTKYRGDFEKRFKALLKQLEQDTNS-ILFIDEIHTIIGAGAASGGqVDA 303

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 313 SNLLKPALARGELRTIAATTWSEYKKYFEKDAALARRFQLVQVKEPTSADAIIIMRGLRAIYEKAHNVFIDDEALRASAE 392
Cdd:PRK11034 304 ANLIKPLLSSGKIRVIGSTTYQEFSNIFEKDRALARRFQKIDITEPSIEETVQIINGLKPKYEAHHDVRYTAKAVRAAVE 383

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 393 LSERYISGRQLPDKAIDVLDTACARAAInlssppkmlsslktdlqqiemeTAILKREHHLGLdnhserleelaskaneie 472
Cdd:PRK11034 384 LAVKYINDRHLPDKAIDVIDEAGARARL----------------------MPVSKRKKTVNV------------------ 423

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 473 qkaSDIqqaweqqQALVSQIITLrstllddentepqPEETCQVDElKQELQTLDQQLAQLhethllvsphvdkkqiaavi 552
Cdd:PRK11034 424 ---ADI-------ESVVARIARI-------------PEKSVSQSD-RDTLKNLGDRLKML-------------------- 459

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 553 aewtgvplnrlsqdalsivtdlpsyleesIKGQSLAIQCLHKHLLTARADLRRPGRPLGAFLLAGPSGVGKTETVIQIAQ 632
Cdd:PRK11034 460 -----------------------------VFGQDKAIEALTEAIKMSRAGLGHEHKPVGSFLFAGPTGVGKTEVTVQLSK 510

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 633 LMfgGTQYLtTINMSEFQEKHTVSRLIGSPPGYVGYGEGGILTEAIRQKPYSVVLLDEVEKAHPDVLNLFYQAFDKGEIA 712
Cdd:PRK11034 511 AL--GIELL-RFDMSEYMERHTVSRLIGAPPGYVGFDQGGLLTDAVIKHPHAVLLLDEIEKAHPDVFNLLLQVMDNGTLT 587

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 713 DGEGRVIDCKNIAFFLTSNLGDHVITAYA---DKPDELQDALyPELTTFFKPALLARME-IVPYLPLSADILRQIVDSKL 788
Cdd:PRK11034 588 DNNGRKADFRNVVLVMTTNAGVRETERKSiglIHQDNSTDAM-EEIKKIFTPEFRNRLDnIIWFDHLSTDVIHQVVDKFI 666

                        650
                 ....*....|
gi 491046388 789 TRLMILLKQR 798
Cdd:PRK11034 667 VELQAQLDQK 676
RecA-like_ClpB_Hsp104-like cd19499
Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and ...
 571-772 1.57e-80

Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and eukaryotic Heat shock protein 104 (Hsp104) are ATP-dependent molecular chaperones and essential proteins of the heat-shock response. ClpB/Hsp104 ATPases, in concert with the DnaK/Hsp70 chaperone system, disaggregate and reactivate aggregated proteins. This RecA-like_ClpB_Hsp104_like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410907 [Multi-domain]  Cd Length: 178  Bit Score: 257.11  E-value: 1.57e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 571 VTDLPSYLEESIKGQSLAIQCLHKHLLTARADLRRPGRPLGAFLLAGPSGVGKTETVIQIAQLMFGGTQYLTTINMSEFQ 650
Cdd:cd19499    2 LLNLEERLHERVVGQDEAVKAVSDAIRRARAGLSDPNRPIGSFLFLGPTGVGKTELAKALAELLFGDEDNLIRIDMSEYM 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 651 EKHTVSRLIGSPPGYVGYGEGGILTEAIRQKPYSVVLLDEVEKAHPDVLNLFYQAFDKGEIADGEGRVIDCKNIAFFLTS 730
Cdd:cd19499   82 EKHSVSRLIGAPPGYVGYTEGGQLTEAVRRKPYSVVLLDEIEKAHPDVQNLLLQVLDDGRLTDSHGRTVDFKNTIIIMTS 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 491046388 731 NlgdhvitayadkpdelqdalypelttFFKPALLARMEIVPY 772
Cdd:cd19499  162 N--------------------------HFRPEFLNRIDEIVV 177
AAA_2 pfam07724
AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected ...
 608-770 1.84e-66

AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400187 [Multi-domain]  Cd Length: 168  Bit Score: 218.99  E-value: 1.84e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  608 RPLGAFLLAGPSGVGKTETVIQIAQLMFGGTQYLTTINMSEFQEKHTVSRLIGSPPGYVGYGEGGILTEAIRQKPYSVVL 687
Cdd:pfam07724   1 RPIGSFLFLGPTGVGKTELAKALAELLFGDERALIRIDMSEYMEEHSVSRLIGAPPGYVGYEEGGQLTEAVRRKPYSIVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  688 LDEVEKAHPDVLNLFYQAFDKGEIADGEGRVIDCKNIAFFLTSNLG-----DHVITAYADKPDELQDALYPELTTFFKPA 762
Cdd:pfam07724  81 IDEIEKAHPGVQNDLLQILEGGTLTDKQGRTVDFKNTLFIMTGNFGsekisDASRLGDSPDYELLKEEVMDLLKKGFIPE 160


                  ....*...
gi 491046388  763 LLARMEIV 770
Cdd:pfam07724 161 FLGRLPII 168
AAA_lid_9 pfam17871
AAA lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
 361-464 7.97e-36

AAA lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


Pssm-ID: 465544 [Multi-domain]  Cd Length: 104  Bit Score: 131.07  E-value: 7.97e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  361 ADAIIIMRGLRAIYEKAHNVFIDDEALRASAELSERYISGRQLPDKAIDVLDTACARAAINLSSPPKMLSSLKTDLQQIE 440
Cdd:pfam17871   3 EEAIEILRGLKPKYEKHHGVRISDEALEAAVKLSKRYITDRFLPDKAIDLLDEACARVRLSQESKPEELEDLERELAKLE 82

                          90       100
                  ....*....|....*....|....
gi 491046388  441 METAILKREHHlglDNHSERLEEL 464
Cdd:pfam17871  83 IEKEALEREQD---FEKAERLAKL 103
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 200-353 3.60e-16

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 76.42  E-value: 3.60e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 200 RDHEIDLMIDILCRRRKNNPVVVGEPGVGKSALieglaLRIIAGEIPEklRGCELLTLDLGALQAGAAVKGEFEKRFKGI 279
Cdd:cd00009    3 QEEAIEALREALELPPPKNLLLYGPPGTGKTTL-----ARAIANELFR--PGAPFLYLNASDLLEGLVVAELFGHFLVRL 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491046388 280 MQEVSQSPHPIILFIDEAHTLiGAGNQQGGLDVSNLLKPALA-RGELRTIAATTwseYKKYFEKDAALARRFQLV 353
Cdd:cd00009   76 LFELAEKAKPGVLFIDEIDSL-SRGAQNALLRVLETLNDLRIdRENVRVIGATN---RPLLGDLDRALYDRLDIR 146
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 595-734 6.07e-11

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 61.39  E-value: 6.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 595 HLLTARADLRRPGRPLGAFLLAGPSGVGKTETVIQIAQLMFGGTQYLTTINMSEFQEKHTVSRLIgsppgyvGYGEGGIL 674
Cdd:cd00009    4 EEAIEALREALELPPPKNLLLYGPPGTGKTTLARAIANELFRPGAPFLYLNASDLLEGLVVAELF-------GHFLVRLL 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 675 TEAIRQKPYSVVLLDEVEKAHPDVLNLFYQAFDKGEIadgegRVIDCKNIAFFLTSNLGD 734
Cdd:cd00009   77 FELAEKAKPGVLFIDEIDSLSRGAQNALLRVLETLND-----LRIDRENVRVIGATNRPL 131
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 221-351 4.09e-10

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 58.37  E-value: 4.09e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  221 VVGEPGVGKSALIeglalRIIAGEIpeklrGCELLTLDLGALQAGAAvkGEFEKRFKGIMQEVsQSPHPIILFIDEAHTL 300
Cdd:pfam00004   3 LYGPPGTGKTTLA-----KAVAKEL-----GAPFIEISGSELVSKYV--GESEKRLRELFEAA-KKLAPCVIFIDEIDAL 69

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  301 IGAGNQQG---GLDVSNLLKPALARGELRT-----IAATTwseykkYFEK-DAALARRFQ 351
Cdd:pfam00004  70 AGSRGSGGdseSRRVVNQLLTELDGFTSSNskvivIAATN------RPDKlDPALLGRFD 123
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 613-767 4.26e-10

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 58.46  E-value: 4.26e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  613 FLLAGPSGVGKTETVIQIAQLMFGGTqyLTTINMSEFQekhTVSRLIGS--PPGYVGYGEGGILTEAIRQKpySVVLLDE 690
Cdd:pfam07728   2 VLLVGPPGTGKTELAERLAAALSNRP--VFYVQLTRDT---TEEDLFGRrnIDPGGASWVDGPLVRAAREG--EIAVLDE 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491046388  691 VEKAHPDVLNLFYQAFDKGEIADGEGR-VIDCKNIAFfltsnlgdHVITAYADKPDELQDALypelttffkPALLARM 767
Cdd:pfam07728  75 INRANPDVLNSLLSLLDERRLLLPDGGeLVKAAPDGF--------RLIATMNPLDRGLNELS---------PALRSRF 135
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 614-739 3.07e-09

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 56.61  E-value: 3.07e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388   614 LLAGPSGVGKTETVIQIAQLMFGGTQYLTTINMSEFQEKHTVSRLIGSPPGYVGYGEGG----ILTEAIRQKPYSVVLLD 689
Cdd:smart00382   6 LIVGPPGSGKTTLARALARELGPPGGGVIYIDGEDILEEVLDQLLLIIVGGKKASGSGElrlrLALALARKLKPDVLILD 85

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 491046388   690 EVEKAHPDVLNLFYQAFDKGEIADGEGRvidCKNIAFFLTSNLGDHVITA 739
Cdd:smart00382  86 EITSLLDAEQEALLLLLEELRLLLLLKS---EKNLTVILTTNDEKDLGPA 132
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 215-355 1.26e-08

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 54.69  E-value: 1.26e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388   215 RKNNPVVVGEPGVGKSALieglaLRIIAGEIPEKLRGCELLTLD----------LGALQAGAAVKGEFEKRFKGIMQEVs 284
Cdd:smart00382   1 PGEVILIVGPPGSGKTTL-----ARALARELGPPGGGVIYIDGEdileevldqlLLIIVGGKKASGSGELRLRLALALA- 74

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491046388   285 QSPHPIILFIDEAHTLIGAGNQQGGLD--VSNLLKPALARGELRTIAATTWSEykkyFEKDAALARRFQLVQV 355
Cdd:smart00382  75 RKLKPDVLILDEITSLLDAEQEALLLLleELRLLLLLKSEKNLTVILTTNDEK----DLGPALLRRRFDRRIV 143
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 222-428 2.08e-07

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 54.15  E-value: 2.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 222 VGEPGVGKSALIeglalRIIAGEIpeklrGCELLTLDLGALQAGAAvkGEFEKRFKGIMQEVSQSpHPIILFIDEAHTLI 301
Cdd:COG0464  197 YGPPGTGKTLLA-----RALAGEL-----GLPLIEVDLSDLVSKYV--GETEKNLREVFDKARGL-APCVLFIDEADALA 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 302 GAGNQQGGLD----VSNLLKpALA--RGELRTIAATTwseykkYFEK-DAALARRFQL-VQVKEPTSAdaiiimrGLRAI 373
Cdd:COG0464  264 GKRGEVGDGVgrrvVNTLLT-EMEelRSDVVVIAATN------RPDLlDPALLRRFDEiIFFPLPDAE-------ERLEI 329

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 491046388 374 YEK-AHNVFIDDEA-LRASAELSERYiSGRQLpdkaIDVLDTACARAAINLSSPPKM 428
Cdd:COG0464  330 FRIhLRKRPLDEDVdLEELAEATEGL-SGADI----RNVVRRAALQALRLGREPVTT 381
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 595-739 2.51e-06

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 48.05  E-value: 2.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 595 HLLTARADLRRPGRPLGA-FLLAGPSGVGKTETVIQIAQlMFGGTqyLTTINMSEFQEKhtvsrligsppgYVGYGEGGI 673
Cdd:cd19481   10 EAPRRGSRLRRYGLGLPKgILLYGPPGTGKTLLAKALAG-ELGLP--LIVVKLSSLLSK------------YVGESEKNL 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 674 --LTEAIRQKPYSVVLLDEVEKAHPD------------VLNLFYQAFDKGEIadgegrvidCKNIAFFLTSNLGDHVITA 739
Cdd:cd19481   75 rkIFERARRLAPCILFIDEIDAIGRKrdssgesgelrrVLNQLLTELDGVNS---------RSKVLVIAATNRPDLLDPA 145
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
 196-298 3.75e-06

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 47.88  E-value: 3.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  196 PVLCRDHEIDLMIDILCRRRKNNP---VVVGEPGVGKSALIEGLA---------------------------------LR 239
Cdd:pfam13191   1 RLVGREEELEQLLDALDRVRSGRPpsvLLTGEAGTGKTTLLRELLralerdggyflrgkcdenlpyspllealtreglLR 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491046388  240 IIAGEIPEKLRGcELLTLDLGALQAGAAVKGEFEKRFKGIMQEV----SQSPHPIILFIDEAH 298
Cdd:pfam13191  81 QLLDELESSLLE-AWRAALLEALAPVPELPGDLAERLLDLLLRLldllARGERPLVLVLDDLQ 142
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 614-775 9.71e-06

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 45.66  E-value: 9.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  614 LLAGPSGVGKTETVIQIAQLMfgGTQYLtTINMSEFQEKhtvsrligsppgYVGYGEG---GILTEAIRQKPySVVLLDE 690
Cdd:pfam00004   2 LLYGPPGTGKTTLAKAVAKEL--GAPFI-EISGSELVSK------------YVGESEKrlrELFEAAKKLAP-CVIFIDE 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  691 VEKAHP-----------DVLNLFYQAFDKGEIADGegrvidckNIAFFLTSNlgdhvitaYADKPDelqdalypelttff 759
Cdd:pfam00004  66 IDALAGsrgsggdsesrRVVNQLLTELDGFTSSNS--------KVIVIAATN--------RPDKLD-------------- 115

                         170
                  ....*....|....*.
gi 491046388  760 kPALLARMEIVPYLPL 775
Cdd:pfam00004 116 -PALLGRFDRIIEFPL 130
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
222-421 7.40e-05

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 45.26  E-value: 7.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 222 VGEPGVGKSALIEGLAlriiaGEIpeklrGCELLTLDLGALqAGAAVkGEFEKRFKGIMQEVSQspHPIILFIDEAHTlI 301
Cdd:COG1223   41 YGPPGTGKTMLAEALA-----GEL-----KLPLLTVRLDSL-IGSYL-GETARNLRKLFDFARR--APCVIFFDEFDA-I 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 302 GA--GNQQGGLDVSNLLKPALA-----RGELRTIAATtwseykkYFEK--DAALARRFQLV-QVKEPTSADAIIIMRglR 371
Cdd:COG1223  106 AKdrGDQNDVGEVKRVVNALLQeldglPSGSVVIAAT-------NHPEllDSALWRRFDEViEFPLPDKEERKEILE--L 176

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 491046388 372 AIYEKAHNVFIDDEALrasAELSERyISGRQLpdkaIDVLDTACARAAIN 421
Cdd:COG1223  177 NLKKFPLPFELDLKKL---AKKLEG-LSGADI----EKVLKTALKKAILE 218
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 223-394 1.52e-04

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 45.08  E-value: 1.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 223 GEPGVGKSALIeglalRIIAGEIpeklrGCELLTLDlgALQAG-AAVKGEFEKrfkgiMQEVSQSPHPIILFIDEAHTLi 301
Cdd:PRK13342  43 GPPGTGKTTLA-----RIIAGAT-----DAPFEALS--AVTSGvKDLREVIEE-----ARQRRSAGRRTILFIDEIHRF- 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 302 gagN--QQgglDVsnLLkPALARGELRTIAATTwsEyKKYFEKDAALARRFQLVQVKEPTSADAIIIMRglRAIYEKAHN 379
Cdd:PRK13342 105 ---NkaQQ---DA--LL-PHVEDGTITLIGATT--E-NPSFEVNPALLSRAQVFELKPLSEEDIEQLLK--RALEDKERG 170

                        170
                 ....*....|....*.
gi 491046388 380 VF-IDDEALRASAELS 394
Cdd:PRK13342 171 LVeLDDEALDALARLA 186
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 427-535 1.83e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 45.40  E-value: 1.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388  427 KMLSSLKTDLQQIEmetailKREHHLGLDNhSERLEELASKANEIEQKASDIQQAWEQQQALVSQIITLRSTLLDDENTE 506
Cdd:TIGR04523 335 KIISQLNEQISQLK------KELTNSESEN-SEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLN 407

                          90       100
                  ....*....|....*....|....*....
gi 491046388  507 PQPEEtcQVDELKQELQTLDQQLAQLHET 535
Cdd:TIGR04523 408 QQKDE--QIKKLQQEKELLEKEIERLKET 434
46 PHA02562
endonuclease subunit; Provisional
 376-585 2.79e-04

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 44.62  E-value: 2.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 376 KAHNVFIDDeaLRAS-----AELSERYISGRQLPDK---AIDVLDTACARAAINLSSPPKMLSSLKTDLQQIEMETAILK 447
Cdd:PHA02562 198 KTYNKNIEE--QRKKngeniARKQNKYDELVEEAKTikaEIEELTDELLNLVMDIEDPSAALNKLNTAAAKIKSKIEQFQ 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 448 REHHL------------GLDNHSERLEELASKANEIEQKASDIQQAWEQQQALVSQIITLRSTLLDDENtepqpeetcQV 515
Cdd:PHA02562 276 KVIKMyekggvcptctqQISEGPDRITKIKDKLKELQHSLEKLDTAIDELEEIMDEFNEQSKKLLELKN---------KI 346

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 491046388 516 DELKQELQTLDQQLAQLH-ETHLLVSPHVDKK-QIAAVIAEWTGVPLNR----LSQDALSIVTDLpsyLEES-IKGQ 585
Cdd:PHA02562 347 STNKQSLITLVDKAKKVKaAIEELQAEFVDNAeELAKLQDELDKIVKTKselvKEKYHRGIVTDL---LKDSgIKAS 420
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 222-320 3.89e-04

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 41.88  E-value: 3.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 222 VGEPGVGKSALIeglalRIIAGEIpeklrGCELLTLDLGALQAGAavKGEFEKRFKGIMQEVSQSPhPIILFIDEAHTLI 301
Cdd:cd19481   32 YGPPGTGKTLLA-----KALAGEL-----GLPLIVVKLSSLLSKY--VGESEKNLRKIFERARRLA-PCILFIDEIDAIG 98

                         90
                 ....*....|....*....
gi 491046388 302 GAGNQQGGLDVSNLLKPAL 320
Cdd:cd19481   99 RKRDSSGESGELRRVLNQL 117
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
429-532 1.56e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 42.31  E-value: 1.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 429 LSSLKTDLQQIEMETAILKREHhlGLDNHSERLEELASKANEIEQKASDIQQaweQQQALVSQIITLRSTLLDDENTEPQ 508
Cdd:COG3206  184 LPELRKELEEAEAALEEFRQKN--GLVDLSEEAKLLLQQLSELESQLAEARA---ELAEAEARLAALRAQLGSGPDALPE 258

                         90       100
                 ....*....|....*....|....
gi 491046388 509 PEETCQVDELKQELQTLDQQLAQL 532
Cdd:COG3206  259 LLQSPVIQQLRAQLAELEAELAEL 282
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
 223-394 2.25e-03

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 41.58  E-value: 2.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 223 GEPGVGKSALieglAlRIIAGEIpeklrGCELLTLDlgALQAGAA-VKGEFEKrfkgiMQEVSQSPHPIILFIDEAHTLi 301
Cdd:COG2256   56 GPPGTGKTTL----A-RLIANAT-----DAEFVALS--AVTSGVKdIREVIEE-----ARERRAYGRRTILFVDEIHRF- 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 302 gagN--QQgglDVsnLLkPALARGELRTIAATTwsEyKKYFEKDAALARRFQLVQVKEPTSADAIIIMRglRAIYEK--- 376
Cdd:COG2256  118 ---NkaQQ---DA--LL-PHVEDGTITLIGATT--E-NPSFEVNSALLSRCRVFVLKPLSEEDLEQLLE--RALADDerg 183

                        170       180
                 ....*....|....*....|
gi 491046388 377 --AHNVFIDDEALRASAELS 394
Cdd:COG2256  184 lgGYKLELDDEALEALARLA 203
ClpB_D2-small smart01086
C-terminal, D2-small domain, of ClpB protein; This is the C-terminal domain of ClpB protein, ...
 775-831 2.30e-03

C-terminal, D2-small domain, of ClpB protein; This is the C-terminal domain of ClpB protein, referred to as the D2-small domain, and is a mixed alpha-beta structure. Compared with the D1-small domain (included in AAA) it lacks the long coiled-coil insertion, and instead of helix C4 contains a beta-strand (e3) that is part of a three stranded beta-pleated sheet. In Thermophilus the whole protein forms a hexamer with the D1-small and D2-small domains located on the outside of the hexamer, with the long coiled-coil being exposed on the surface. The D2-small domain is essential for oligomerisation, forming a tight interface with the D2-large domain of a neighbouring subunit and thereby providing enough binding energy to stabilise the functional assembly. The domain is associated with two Clp_N at the N-terminus as well as AAA and AAA_2.


Pssm-ID: 198154 [Multi-domain]  Cd Length: 90  Bit Score: 37.81  E-value: 2.30e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 491046388   775 LSADILRQIVDSKLTRLMILLKQRfNAKIQLEESVPNEILRRASRAENGARILESII 831
Cdd:smart01086   1 LDKEDLVRIVDLPLNALQKRLAEK-GITLEFTDEALDWLAEKGYDPKYGARPLRRII 56
ExeA COG3267
Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, ...
 220-300 2.74e-03

Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 442498 [Multi-domain]  Cd Length: 261  Bit Score: 40.54  E-value: 2.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 220 VVVGEPGVGKSALieglaLRIIAGEIPEKLRGC----------ELLT---LDLGaLQAGAAVKGEFEKRFKGIMQEVSQS 286
Cdd:COG3267   47 VLTGEVGTGKTTL-----LRRLLERLPDDVKVAyipnpqlspaELLRaiaDELG-LEPKGASKADLLRQLQEFLLELAAA 120

                         90
                 ....*....|....
gi 491046388 287 PHPIILFIDEAHTL 300
Cdd:COG3267  121 GRRVVLIIDEAQNL 134
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
429-554 5.12e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 40.27  E-value: 5.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 429 LSSLKTDLQQIEMETAILKREHHLGLDNHSERLEELASKANEIEQKASDIQQAWEQQQALVSQIITLRSTLLDDENTEPQ 508
Cdd:COG4372   68 LEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAE 147

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 491046388 509 PEEtcQVDELKQELQTLDQQLAQLHETHLLVSPHVDKKQIAAVIAE 554
Cdd:COG4372  148 REE--ELKELEEQLESLQEELAALEQELQALSEAEAEQALDELLKE 191
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
411-536 8.09e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 39.75  E-value: 8.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491046388 411 LDTACARAAINLSSPPKMLSSLKTDLQQI-EMETAILKREHHLGLDNHSERLEELASKAN-----EIEQKAsdiqQAWEQ 484
Cdd:COG4717  321 LEELLAALGLPPDLSPEELLELLDRIEELqELLREAEELEEELQLEELEQEIAALLAEAGvedeeELRAAL----EQAEE 396

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 491046388 485 QQALVSQIITLRSTLLDDENTEPQPEETCQVDELKQELQTLDQQLAQLHETH 536
Cdd:COG4717  397 YQELKEELEELEEQLEELLGELEELLEALDEEELEEELEELEEELEELEEEL 448
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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