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Conserved domains on  [gi|491044121|ref|WP_004905783|]
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MULTISPECIES: cupin domain-containing protein [Providencia]

Protein Classification

cupin domain-containing protein( domain architecture ID 10007407)

cupin domain-containing protein, part of a functionally diverse superfamily with the active site generally located at the center of a conserved domain forming a beta-barrel fold

CATH:  2.60.120.10
Gene Ontology:  GO:0046872
PubMed:  19478949|14697267|9573603
SCOP:  3001825

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3450 COG3450
Predicted enzyme of the cupin superfamily [General function prediction only];
19-116 1.77e-26

Predicted enzyme of the cupin superfamily [General function prediction only];


:

Pssm-ID: 442673  Cd Length: 108  Bit Score: 94.66  E-value: 1.77e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491044121  19 SVTNLGSVVVEGDPQASVAMIHGEPTDNLTCGIFACTKGKFKMVYPFDEMATVHEGSVKLTDVkTGVTVEYHKGDTWFAA 98
Cdd:COG3450   10 SDPPAPERILEGDPSARTWNLFTSPDGGVSAGVWECTPGKFRWDYDEDEFCYILEGRVTVTDD-DGEPVEFGAGDSFVFP 88

                         90
                 ....*....|....*...
gi 491044121  99 KGTEVLWEIDVPrFVKHY 116
Cdd:COG3450   89 AGFKGTWEVLET-VRKHY 105
 
Name Accession Description Interval E-value
COG3450 COG3450
Predicted enzyme of the cupin superfamily [General function prediction only];
19-116 1.77e-26

Predicted enzyme of the cupin superfamily [General function prediction only];


Pssm-ID: 442673  Cd Length: 108  Bit Score: 94.66  E-value: 1.77e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491044121  19 SVTNLGSVVVEGDPQASVAMIHGEPTDNLTCGIFACTKGKFKMVYPFDEMATVHEGSVKLTDVkTGVTVEYHKGDTWFAA 98
Cdd:COG3450   10 SDPPAPERILEGDPSARTWNLFTSPDGGVSAGVWECTPGKFRWDYDEDEFCYILEGRVTVTDD-DGEPVEFGAGDSFVFP 88

                         90
                 ....*....|....*...
gi 491044121  99 KGTEVLWEIDVPrFVKHY 116
Cdd:COG3450   89 AGFKGTWEVLET-VRKHY 105
Cupin_3 pfam05899
EutQ-like cupin domain; This entry represents the cupin domain, with a conserved jelly ...
 41-116 7.40e-18

EutQ-like cupin domain; This entry represents the cupin domain, with a conserved jelly roll-like beta-barrel fold capable of homodimerization found in bacteria, plant and fungi. It is present in EutQ family from the eut operon, involved in ethanolamine degradation. EutQ is essential during anoxic growth and has acetate kinase activity. The cupin domain from EutQ does not possess the His residues responsible for metal coordination in other classes of cupins. This domain is also found in (S)-ureidoglycine aminohydrolase (UGlyAH) from E.coli, which is involved in the anaerobic nitrogen utilization via the assimilation of allantoin. It catalyzes the deamination of allantoin to produce S-ureidoglycolate and ammonia from S-ureidoglycine.


Pssm-ID: 399116 [Multi-domain]  Cd Length: 74  Bit Score: 71.94  E-value: 7.40e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491044121   41 GEPTDNLTCGIFACTKGKFKMVYPFDEMATVHEGSVKLTdVKTGVTVEYHKGDTWFAAKGTEVLWEIDVPrFVKHY 116
Cdd:pfam05899   1 LSPLGVFSWGIWECTPGKFRWTYEEDETCYILSGEVTVT-PEGGKTVTLRAGDLVVLPKGLSGTWDVLET-VRKHY 74
cupin_TM1112-like cd02227
Thermotoga maritima TM1112 and related proteins, cupin domain; This family includes bacterial ...
 48-116 2.89e-12

Thermotoga maritima TM1112 and related proteins, cupin domain; This family includes bacterial and plant proteins homologous to TM1112, a Thermotoga maritima protein of unknown function with a cupin beta barrel domain. TM1112 (also known as DUF861) is a subfamily of RmlC-like cupins with a conserved "jelly roll-like" beta-barrel fold; structures indicate that a monomer is the biologically-relevant form.


Pssm-ID: 380356 [Multi-domain]  Cd Length: 69  Bit Score: 57.21  E-value: 2.89e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491044121  48 TCGIFACTKGKFKMVYPFDEMATVHEGSVKLTDvKTGVTVEYHKGDTWFAAKGTEVLWEIDVP-RfvKHY 116
Cdd:cd02227    1 SWGIWECTPGKFPWNYDEDEFCYILEGEVRVTP-EDGEPVTFKAGDLVVFPAGFSGTWEVLEPvR--KHY 67
 
Name Accession Description Interval E-value
COG3450 COG3450
Predicted enzyme of the cupin superfamily [General function prediction only];
19-116 1.77e-26

Predicted enzyme of the cupin superfamily [General function prediction only];


Pssm-ID: 442673  Cd Length: 108  Bit Score: 94.66  E-value: 1.77e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491044121  19 SVTNLGSVVVEGDPQASVAMIHGEPTDNLTCGIFACTKGKFKMVYPFDEMATVHEGSVKLTDVkTGVTVEYHKGDTWFAA 98
Cdd:COG3450   10 SDPPAPERILEGDPSARTWNLFTSPDGGVSAGVWECTPGKFRWDYDEDEFCYILEGRVTVTDD-DGEPVEFGAGDSFVFP 88

                         90
                 ....*....|....*...
gi 491044121  99 KGTEVLWEIDVPrFVKHY 116
Cdd:COG3450   89 AGFKGTWEVLET-VRKHY 105
Cupin_3 pfam05899
EutQ-like cupin domain; This entry represents the cupin domain, with a conserved jelly ...
 41-116 7.40e-18

EutQ-like cupin domain; This entry represents the cupin domain, with a conserved jelly roll-like beta-barrel fold capable of homodimerization found in bacteria, plant and fungi. It is present in EutQ family from the eut operon, involved in ethanolamine degradation. EutQ is essential during anoxic growth and has acetate kinase activity. The cupin domain from EutQ does not possess the His residues responsible for metal coordination in other classes of cupins. This domain is also found in (S)-ureidoglycine aminohydrolase (UGlyAH) from E.coli, which is involved in the anaerobic nitrogen utilization via the assimilation of allantoin. It catalyzes the deamination of allantoin to produce S-ureidoglycolate and ammonia from S-ureidoglycine.


Pssm-ID: 399116 [Multi-domain]  Cd Length: 74  Bit Score: 71.94  E-value: 7.40e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491044121   41 GEPTDNLTCGIFACTKGKFKMVYPFDEMATVHEGSVKLTdVKTGVTVEYHKGDTWFAAKGTEVLWEIDVPrFVKHY 116
Cdd:pfam05899   1 LSPLGVFSWGIWECTPGKFRWTYEEDETCYILSGEVTVT-PEGGKTVTLRAGDLVVLPKGLSGTWDVLET-VRKHY 74
cupin_TM1112-like cd02227
Thermotoga maritima TM1112 and related proteins, cupin domain; This family includes bacterial ...
 48-116 2.89e-12

Thermotoga maritima TM1112 and related proteins, cupin domain; This family includes bacterial and plant proteins homologous to TM1112, a Thermotoga maritima protein of unknown function with a cupin beta barrel domain. TM1112 (also known as DUF861) is a subfamily of RmlC-like cupins with a conserved "jelly roll-like" beta-barrel fold; structures indicate that a monomer is the biologically-relevant form.


Pssm-ID: 380356 [Multi-domain]  Cd Length: 69  Bit Score: 57.21  E-value: 2.89e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491044121  48 TCGIFACTKGKFKMVYPFDEMATVHEGSVKLTDvKTGVTVEYHKGDTWFAAKGTEVLWEIDVP-RfvKHY 116
Cdd:cd02227    1 SWGIWECTPGKFPWNYDEDEFCYILEGEVRVTP-EDGEPVTFKAGDLVVFPAGFSGTWEVLEPvR--KHY 67
cupin_EutQ cd02228
Clostridium difficile EutQ and related proteins, cupin domain; This family includes bacterial ...
 46-106 3.48e-07

Clostridium difficile EutQ and related proteins, cupin domain; This family includes bacterial and fungal proteins homologous to ethanolamine utilization protein EutQ found in Clostridium difficile, as well as in other bacteria, including the enteric pathogens Salmonella enterica and Enterococcus faecalis. EutQ is encoded by the eutQ gene which is part of the eut (ethanolamine utilization) operon found to be essential during anoxic growth of S. enterica on ethanolamine and tetrathionate. In C. difficile, inability to utilize ethanolamine results in greater virulence and a shorter time to morbidity in the animal model, suggesting that, in contrast to other intestinal pathogens, the metabolism of ethanolamine can delay the onset of disease. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization. In contrast to the metal-binding catalytic cupins, the EutQ family does not possess the histidine residues that are responsible for metal coordination in the oxidoreductase and epimerase classes of cupins.


Pssm-ID: 380357 [Multi-domain]  Cd Length: 84  Bit Score: 44.42  E-value: 3.48e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491044121  46 NLTCGIFACTKGKFKMVYPFDEMATVHEGSVKLTDvkTGVTVEYHKGDTWFAAKGTEVLWE 106
Cdd:cd02228   14 PMSAGFMELEKKSFPWTLTYDEIKYVLEGELEITD--DGQTVTAKPGDVLFIPKGSKITFS 72
EutQ COG4766
Ethanolamine utilization protein EutQ, cupin superfamily (function unknown) [Amino acid ...
 46-106 1.98e-05

Ethanolamine utilization protein EutQ, cupin superfamily (function unknown) [Amino acid transport and metabolism];


Pssm-ID: 443798  Cd Length: 123  Bit Score: 40.74  E-value: 1.98e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491044121  46 NLTCGIFACTKGKFKMVYPFDEMATVHEGSVKLTDVktGVTVEYHKGDTWFAAKGTEVLWE 106
Cdd:COG4766   48 RMGAGFMRLEKTTFPWTLTYDEVDYVLEGTLTIEID--GETVTAGPGDVIYIPKGSSITFS 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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