P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491040694  27 IVVIIGPSGSGKTLLAK--RALIDGLFISPDEpiANEEFIQSLSNKDIIIDDV--------VLFDVRNMLK 87
Cdd:PRK09087  46 VVVLAGPVGSGKTHLASiwREKSDALLIHPNE--IGSDAANAAAEGPVLIEDIdaggfdetGLFHLINSVR 114

hypothetical protein; Validated

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491040694  27 IVVIIGPSGSGKTLLAK--RALIDGLFISPDEpiANEEFIQSLSNKDIIIDDV--------VLFDVRNMLK 87
Cdd:PRK09087  46 VVVLAGPVGSGKTHLASiwREKSDALLIHPNE--IGSDAANAAAEGPVLIEDIdaggfdetGLFHLINSVR 114

ATP-binding cassette domain similar to the molybdate transporter; Archaeal protein closely related to ModC. ModC is an ABC-type transporter and the ATPase component of a molybdate transport system that also includes the periplasmic binding protein ModA and the membrane protein ModB. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491040694  12 LNKVLSFFSEKDTNLIV------VIIGPSGSGKTLLAKraLIDGlFISPD--EPIANEEFIQSLS----NKDIIIDDVVL 79
Cdd:cd03299    6 LSKDWKEFKLKNVSLEVergdyfVILGPTGSGKSVLLE--TIAG-FIKPDsgKILLNGKDITNLPpekrDISYVPQNYAL 82

                         90       100
                 ....*....|....*....|....*....
gi 491040694  80 FDVRNmlkyVLQSLASGRKVILTGRPEDE 108
Cdd:cd03299   83 FPHMT----VYKNIAYGLKKRKVDKKEIE 107

hypothetical protein; Validated

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491040694  27 IVVIIGPSGSGKTLLAK--RALIDGLFISPDEpiANEEFIQSLSNKDIIIDDV--------VLFDVRNMLK 87
Cdd:PRK09087  46 VVVLAGPVGSGKTHLASiwREKSDALLIHPNE--IGSDAANAAAEGPVLIEDIdaggfdetGLFHLINSVR 114

ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism];

                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 491040694  13 NKVLsffseKDTNL------IVVIIGPSGSGK-TLL 41
Cdd:COG1126   14 LEVL-----KGISLdvekgeVVVIIGPSGSGKsTLL 44

ATP-binding cassette domain similar to the molybdate transporter; Archaeal protein closely related to ModC. ModC is an ABC-type transporter and the ATPase component of a molybdate transport system that also includes the periplasmic binding protein ModA and the membrane protein ModB. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491040694  12 LNKVLSFFSEKDTNLIV------VIIGPSGSGKTLLAKraLIDGlFISPD--EPIANEEFIQSLS----NKDIIIDDVVL 79
Cdd:cd03299    6 LSKDWKEFKLKNVSLEVergdyfVILGPTGSGKSVLLE--TIAG-FIKPDsgKILLNGKDITNLPpekrDISYVPQNYAL 82

                         90       100
                 ....*....|....*....|....*....
gi 491040694  80 FDVRNmlkyVLQSLASGRKVILTGRPEDE 108
Cdd:cd03299   83 FPHMT----VYKNIAYGLKKRKVDKKEIE 107

ABC-type protease/lipase transport system, ATPase and permease components [Intracellular trafficking, secretion, and vesicular transport];

                         10        20
                 ....*....|....*....|
gi 491040694  27 IVVIIGPSGSGKTLLAkRAL 46
Cdd:COG4618  360 VLGVIGPSGSGKSTLA-RLL 378

ABC-type Fe3+/spermidine/putrescine transport systems, ATPase component [Amino acid transport and metabolism];

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491040694  27 IVVIIGPSGSGKTLLAKraLIDGlFISPDEpianeefiqslsnKDIIIDDVVLFDV----RNMlKYVLQSLA 94
Cdd:COG3842   33 FVALLGPSGCGKTTLLR--MIAG-FETPDS-------------GRILLDGRDVTGLppekRNV-GMVFQDYA 87

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491040694  27 IVVIIGPSGSGKTLLAKR-ALIDGL-FISPDEpIANEEFIQSLSNkdiiidDVVLFDVRNMLKYVLQSLASGRKVILTGR 104
Cdd:cd02020    1 IIAIDGPAGSGKSTVAKLlAKKLGLpYLDTGG-IRTEEVGKLASE------VAAIPEVRKALDERQRELAKKPGIVLEGR 73

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage

                         10
                 ....*....|....*....
gi 491040694  26 LIVVIIGPSGSGKTLLAKR 44
Cdd:COG0572    8 RIIGIAGPSGSGKTTFARR 26

ATP-binding cassette domain of the osmoprotectant transporter; OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition, to the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491040694  27 IVVIIGPSGSGKTLLAKraLIDGLFispdEPIANEEFIQSlsnKDIIIDDVVlfDVRNMLKYVLQS 92
Cdd:cd03295   29 FLVLIGPSGSGKTTTMK--MINRLI----EPTSGEIFIDG---EDIREQDPV--ELRRKIGYVIQQ 83

ATP-binding cassette domain of the histidine and glutamine transporters; HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, respectively. Histidine permease is a multi-subunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP has properties intermediate between those of integral and peripheral membrane proteins and is accessible from both sides of the membrane, presumably by its interaction with HisQ and HisM. The two HisP subunits form a homodimer within the complex. The domain structure of the amino acid uptake systems is typical for prokaryotic extracellular solute binding protein-dependent uptake systems. All of the amino acid uptake systems also have at least one, and in a few cases, two extracellular solute binding proteins located in the periplasm of Gram-negative bacteria, or attached to the cell membrane of Gram-positive bacteria. The best-studied member of the PAAT (polar amino acid transport) family is the HisJQMP system of S. typhimurium, where HisJ is the extracellular solute binding proteins and HisP is the ABC protein.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 491040694  27 IVVIIGPSGSGK-TLLakRAlIDGLfispdepianeEFIQSlsnKDIIIDDVVLFD 81
Cdd:cd03262   28 VVVIIGPSGSGKsTLL--RC-INLL-----------EEPDS---GTIIIDGLKLTD 66

Predicted kinase [General function prediction only];

                         10        20        30
                 ....*....|....*....|....*....|
gi 491040694  27 IVVIIGPSGSGKTLLAKRALIDGLFISPDE 56
Cdd:COG4639    4 LVVLIGLPGSGKSTFARRLFAPTEVVSSDD 33

Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational modification, protein turnover, chaperones];

                         10        20
                 ....*....|....*....|
gi 491040694  25 NLIvvIIGPSGSGKTLLAKR 44
Cdd:COG0606  213 NLL--MIGPPGSGKTMLARR 230

ABC-type ATPase fused to a predicted acetyltransferase domain [General function prediction only];

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 491040694  27 IVVIIGPSGSGKTLLAkRALIDGLFISPDEPIANEEFIQsLSNKDIIIDDV 77
Cdd:COG2401   58 IVLIVGASGSGKSTLL-RLLAGALKGTPVAGCVDVPDNQ-FGREASLIDAI 106

ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism];

                         10        20        30
                 ....*....|....*....|....*....|.
gi 491040694  27 IVVIIGPSGSGK-TLLakRaLIDGLfISPDE 56
Cdd:COG1116   39 FVALVGPSGCGKsTLL--R-LIAGL-EKPTS 65

Energy-coupling factor transporter ATP-binding protein EcfA2 [Inorganic ion transport and metabolism, General function prediction only];

                         10        20        30
                 ....*....|....*....|....*....|
gi 491040694  27 IVVIIGPSGSGKTLLAKraLIDGLfISPDE 56
Cdd:COG1122   29 FVAIIGPNGSGKSTLLR--LLNGL-LKPTS 55