|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
15-392 |
4.59e-94 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 287.16 E-value: 4.59e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 15 IMLLALLTALGPLSIDMYLPALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLF 94
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 95 CVLATNEWSLIAARILQALGGCVGVVMARAAIRDRLDVQGSAQAFSSMMIVMGLAPILAPMIGAWILIWFPWQAIFIALS 174
Cdd:cd17320 81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 175 IVGAICWLCVHFFFKETLATDKRlKLSLYQVATLYGAIFKDASFRLPMFAGCLTGAALFCYISSAPAVFMDQYGLNQQEF 254
Cdd:cd17320 161 LLGLLLLLLVLLFLPETLPEEKR-KPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 255 AYVFGLNAFGIMLMSSLNKHLTTRVEITKRLKAGSMVQVTGASIVLIAGLISAAPLWLVMLGLFLAISGIGLTGPNAMAL 334
Cdd:cd17320 240 GLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSL 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 491023702 335 AMSKQGARAGTASAIMGSMQFACGLLGGVLLNFLIWSASLNMGVMMVLFTLSGFIVVL 392
Cdd:cd17320 320 ALEPFPHVAGTASALLGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLI 377
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
23-399 |
1.23e-78 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 247.14 E-value: 1.23e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 23 ALGPLSIDMYLPALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCVLATNEW 102
Cdd:PRK11102 1 MLMPLAIDMYLPALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTID 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 103 SLIAARILQALGGCVGVVMARAAIRDRLDVQGSAQAFSSMMIVMGLAPILAPMIGAWILIWFPWQAIFIALSIVGAICWL 182
Cdd:PRK11102 81 QLIYMRFLHGLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 183 CVHFFFKETLATDKRLKLSLYQVATLYGAIFKDASFRLPMFAGCLTGAALFCYISSAPAVFMDQYGLNQQEFAYVFGLNA 262
Cdd:PRK11102 161 LVFFFIPETLPKERRQPFHLRTTIRNFASLFRHKRVLGYMLASGFSFAGMFSFLTAGPFVYIELNGVSPQNFGYYFALNI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 263 FGIMLMSSLNKHLTTRVEITKRLKAGSMVQVTgASIVLIAGLISAAPLWLVMLGLFLAISGIGLTGPNAMALAMSKQGAR 342
Cdd:PRK11102 241 VFLFVMTIINSRFVRRVGALNMLRFGLWIQFI-MGIWLVVSALLDLGFWALVVGVAAFVGCVSMISSNAMAVILDEFPHM 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 491023702 343 AGTASAIMGSMQFACGLLGGVLLNFLIWSASLNMGVMMVLFTLSGFIVVLKATRQAK 399
Cdd:PRK11102 320 AGTASSLAGTLRFGIGAIVGALLSLAPFTSAWPMVWSMAFCSILSILFYLYASRPKK 376
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
15-389 |
5.98e-71 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 227.65 E-value: 5.98e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 15 IMLLALLTALGPLSIDMYLPALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLF 94
Cdd:TIGR00710 7 ALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 95 CVLATNEWSLIAARILQALGGCVGVVMARAAIRDRLDVQGSAQAFSSMMIVMGLAPILAPMIGAWILIWFPWQAIFIALS 174
Cdd:TIGR00710 87 LALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLS 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 175 IVGAICWLCVHFFFKETLATDKRLKLSLYqvATLYGAIFKDASFRLPMFAGCLTGAALFCYISSAPAVFMDQYGLNQQEF 254
Cdd:TIGR00710 167 LAGILLSALIFFILPETLPYEARIQISTY--FETFLLLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVF 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 255 AYVFGLNAFGIMLMSSLNKHLTTRVEITKRLKAGSMVQVTGASIVLIAGLISAAPLWLVMLGLFLAISGIGLTGPNAMAL 334
Cdd:TIGR00710 245 GLLFALNIIAMIFGGFLNGRFIKKWGAKSLLRMGLILFAVSAVLLEITAILGLGSWAMIIGPMMFVGIGNSMISSIAMAY 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 491023702 335 AMSKQGARAGTASAIMGSMQFACGLLGGVLLNFLIWSASLNMGVMMVLFTLSGFI 389
Cdd:TIGR00710 325 ALEDFPHVAGTASALFGTLRLVLGAIVGYLVSLIHGNTAWPMSLSCLVLAVVSVL 379
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
9-248 |
5.97e-45 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 160.06 E-value: 5.97e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 9 QYSIGWIMLLALLTALGPLSIDMYLPALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALY 88
Cdd:PRK11043 2 QPSKGFLVYLAGLSMLGFLATDMYLPAFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 89 AVASLFCVLATNEWSLIAARILQALGGCVGVVMARAAIRDRLDVQGSAQAFSSMMIVMGLAPILAPMIGAWILIWFPWQA 168
Cdd:PRK11043 82 ALGSLGMLWVESAAQLLVLRFVQAVGVCSAAVIWQALVIDRYPAQKANRVFATIMPLVALSPALAPLLGAWLLNHFGWQA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 169 IFIALSIVGAICWLCVhFFFKETLATDKRLKLSLyqvatLYGAIFKDASFR--LPMFAGCltGAALFCYISSAPAVfMDQ 246
Cdd:PRK11043 162 IFATLFAITLLLILPT-LRLKPSKKARKQSQDAL-----TFKQLLKSKTYLgnVLIFAAC--SAAFFAWLTGSPFI-LEQ 232
|
..
gi 491023702 247 YG 248
Cdd:PRK11043 233 MG 234
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
5-358 |
1.87e-42 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 152.05 E-value: 1.87e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 5 TAQRQYSIGWIMLLALLTALGPLSIDMYLPALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFG 84
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 85 LALYAVASLFCVLATNEWSLIAARILQALGGCVGVVMARAAIRDRLDVQGSAQAFSSMMIVMGLAPILAPMIGAWILIWF 164
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 165 PWQAIFIALSIVGAICWLCVHFFFKETLATDKRlklslyQVATLYGAIFKDASFRLPMFAGCLTGAALFCYISSAPAVFM 244
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLRLLPESRPAARA------RLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQ 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 245 DQYGLNQQEFAYVFGLNAFGIMLMSSLNKHLTTRVEITKRLKAGSMVqvtgaSIVLIAGLISAAPLWLVMLGLFLAISGI 324
Cdd:COG2814 236 EVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLL-----LALGLLLLALAGSLWLLLLALFLLGFGF 310
|
330 340 350
....*....|....*....|....*....|....*
gi 491023702 325 GLTGPNAMALAMSKQGARA-GTASAIMGSMQFACG 358
Cdd:COG2814 311 GLLFPLLQALVAELAPPEArGRASGLYNSAFFLGG 345
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
15-354 |
3.31e-38 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 141.97 E-value: 3.31e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 15 IMLLALLTALGPLSIDMYLPALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLF 94
Cdd:PRK11652 10 LFMLVLLVAVGQMAQTIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 95 CVLATNEWSLIAARILQALGGCVGVVMARAAIRDRLDvqGSAQAFSSMMIVMGL--APILAPMIGAWILIWFPWQAIFIA 172
Cdd:PRK11652 90 ALFAHSLTVLIAASAIQGLGTGVGGVMARTLPRDLYE--GTQLRHANSLLNMGIlvSPLLAPLIGGLLTTLFGWRACYLF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 173 LSIVGAICWLCVHFFFKETLATDKRLKlslyQVATLYGAIFKDASFR--LPMFAGCLTGAALFcyiSSAPAVFMDQY-GL 249
Cdd:PRK11652 168 LLLLGAGVTFSMARWMPETRPADARRT----RVLASYRTLLSNRRFNcyLLMLIGTLAGIAVF---EACSGVLMGAVlGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 250 NQQEFAYVFGLNA----FGIMLMSSLNKHLTTRVEItkrlkaGSMVQVTGASIVLIAGLISAAPLWLVMLGLFLAISGIG 325
Cdd:PRK11652 241 SSMTVSILFILPIpaafFGAWFAGRPNKRFSTLMWQ------SVICCLLAGLLMWIPGWFGVMNVWTLLVPAALFFFGAG 314
|
330 340
....*....|....*....|....*....
gi 491023702 326 LTGPNAMALAMSKQGARAGTASAIMGSMQ 354
Cdd:PRK11652 315 MLFPLATSGAMEPFPYLAGTAGALLGGLQ 343
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
20-369 |
4.98e-35 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 133.22 E-value: 4.98e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 20 LLTALGPLSIDMYLPALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCVLAT 99
Cdd:PRK10473 10 ALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAE 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 100 NEWSLIAARILQALGGCVGVVMARAAIRDRLDVQGSAQAFSSMMIVMGLAPILAPMIGAWILIWFPWQAIFIALSIVGAI 179
Cdd:PRK10473 90 TSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGIL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 180 CWLCVHFFFKETLATDKRLKLSLYQVATlygAIFKDASFRLPMFAGCLTGAALFCYISSAPAVFMDQYGLNQQEFAYVFG 259
Cdd:PRK10473 170 VLLLSLFILKETRPARAPAASSKPRENS---ESLLNRFFLSRLVITTLSVTVILTFVNTSPVLLMEQMGFSRGEYAIIMA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 260 LNAFGIMLMSSLNKHLTTRVEiTKRLKAGSMVQVTGASIVLIAGLISaaplWLVMLGLFLAISGIGLTGPNAMALAMSKQ 339
Cdd:PRK10473 247 LTAGVSMTVSFSTPFALGIFK-PRTLMLTSQVLFLAAGITLALSPSH----AVSLFGITLICAGFSVGFGVAMSQALGPF 321
|
330 340 350
....*....|....*....|....*....|....*...
gi 491023702 340 GARAGTASAIMGSMQFAC--------GLLGGVLLNFLI 369
Cdd:PRK10473 322 SLRAGVASSTLGIAQVCGsslwiwlaAVLGISAWNMLI 359
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
30-368 |
8.35e-32 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 124.67 E-value: 8.35e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 30 DMYLPALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCVLATNEWSLIAARI 109
Cdd:PRK15402 30 DMIQPGMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRF 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 110 LQALGGCVGVVMARAAIRDRLDVQGSAQAFSSMMIVMGLAPILAPMIGAWILIWFPWQAIFIALSIVGAICWLCVHFFFK 189
Cdd:PRK15402 110 LQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPWRGMFVLFAALAALSFFGLWRAMP 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 190 ETlATDKRLKLSLYQVATLYGAIFKDASFRLPMFAGCLTGAALFCYISSAPAVFMDQYGLNQQEFAyVFGLNAFGIMLMS 269
Cdd:PRK15402 190 ET-AGRVGEKLSLKELGRDYKLVLKNRRFVAGALALGLVSLPLLAWIALSPVILISGEQLSSYEYG-LLQVPVFGALIAG 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 270 SLN-KHLTTRVEITKRLKAGSMVQVTGASIVLIAGLISAAPLWLVMLGLFLAISGIGL--TGPNAMALAMSKQGarAGTA 346
Cdd:PRK15402 268 NLTlARLTSRRPLRSLIRMGLWPMVAGLLLAALATVISSHAYLWLTAGLSLYAFGIGLanAGLYRLTLFSSDVS--KGTV 345
|
330 340
....*....|....*....|..
gi 491023702 347 SAIMGSMQFACGLLGGVLLNFL 368
Cdd:PRK15402 346 SAAMGMLSMLIFTVGIELSKHA 367
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
17-393 |
9.99e-30 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 118.06 E-value: 9.99e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 17 LLALLTALGPLSIDMYLPALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCV 96
Cdd:cd17474 3 AVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 97 LATNEWSLIAARILQALGGCVGVVMARAAIRDRLDVQGSAQAFSSMMIVMGLAPILAPMIGAWILIWfPWQAIFIALSIV 176
Cdd:cd17474 83 LSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPFFLLAAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 177 GAICWLCVHFFFKETLATDKRLKlslYQVATLYGAIFKDASFRLPMFAGCLTGAALFCYISSAPAVFMDQYGLNQQEFAY 256
Cdd:cd17474 162 IPVAFLAILFLLPEPKEKAKSSS---ATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 257 VFGLNAFGIMLMSSLNKHLTTRVEITKRLKAGSMVqVTGASIVLIAGLISaapLWLVMLGLFLAISGIGLTGPNAMALAM 336
Cdd:cd17474 239 LFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLL-LYALSLLLLGFVPS---LALLLIAIVLFGLGLGLNLPLLTTLVT 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 491023702 337 SKQGARA-GTASAIMGSMQFACGLLGGVLLNFLIWSASLNMG-VMMVLFTLSGFIVVLK 393
Cdd:cd17474 315 ELAPEEErGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPfLVGAAIALAAAVLLAL 373
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
27-394 |
6.92e-26 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 107.66 E-value: 6.92e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 27 LSIDMYLPALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCVLATNEWSLIA 106
Cdd:cd17325 10 LGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 107 ARILQALGGCVGVVMARAAIRDRLDVQGSAQAFSSMMIVMGLAPILAPMIGAWILIWFPWQAIFIALSIVGAICWLCVHF 186
Cdd:cd17325 90 ARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 187 FFKETLATDKRLKLSLYQVATLYGAIFKDASFRLPMFAGCLTGAALFCYISSAPAVFMDQYGLNQQEFAYVFGLNAFGIM 266
Cdd:cd17325 170 LLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 267 LMSSLNKHLTTRVEITKRLKAGSMVqvtgaSIVLIAGLISAAPLWLVMLGLFLAISGIGLTGPNAMALA--MSKQGARaG 344
Cdd:cd17325 250 LSQPPAGKLSDRIGRKPLILIGLLL-----SAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLadIVPPEGR-G 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 491023702 345 TASAIMGSMQFACGLLGGVLLNFLI--WSASLNMGVMMVLFTLSGFIVVLKA 394
Cdd:cd17325 324 TAMGLFNTAFSLGMVLGPLLGGFLYdaFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
15-194 |
9.42e-26 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 107.28 E-value: 9.42e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 15 IMLLALLTALGPLSIDMYLPALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLF 94
Cdd:cd17323 1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 95 CVLATNEWSLIAARILQALGGCVGVVMARAAIRDRLDVQ--GSAQAFSSMMIVMGlaPILAPMIGAWILIWFPWQAIFIA 172
Cdd:cd17323 81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEerGKAMGVYSLGPLLG--PALGPIIGGFITQSLGWRWIFWF 158
|
170 180
....*....|....*....|..
gi 491023702 173 LSIVGAICWLCVHFFFKETLAT 194
Cdd:cd17323 159 LAIISGFCLILIFLFLPIVLLL 180
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
18-361 |
1.35e-25 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 106.35 E-value: 1.35e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 18 LALLTALGPLSIDMYLPALPQ-MAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCV 96
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 97 LATNEWSLIAARILQALGGCVGVVMARAAIRDRLDVQGSAQAFSSMMIVMGLAPILAPMIGAWILIWFPWQAIFIALSIV 176
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 177 GAICWLCVHFFFKETLATDKRLKLSLYQVATLYGAIFKDASFRLPMFAGCLTGAALFCYISSAPaVFMDQYGLNQQEFAY 256
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLP-LYQEVLGLSALLAGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 257 VFGLNAFGIMLMSSLNKHLTTRVEITKRLKAGSMVQVTGASIVLIAGLISAAPLWLVMlgLFLAISGIGLTGPNAMALAM 336
Cdd:pfam07690 240 LLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLA--LLLLGFGFGLVFPALNALVS 317
|
330 340
....*....|....*....|....*.
gi 491023702 337 SKQGA-RAGTASAIMGSMQFACGLLG 361
Cdd:pfam07690 318 DLAPKeERGTASGLYNTAGSLGGALG 343
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
18-369 |
2.03e-25 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 106.10 E-value: 2.03e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 18 LALLTALGPLSIDMYLPALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCVL 97
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 98 ATNEWSLIAARILQALGGCVGVVMARAAIRDRLDVQGSAQAFSSMMIVMGLAPILAPMIGAWILIWFPWQAIFIALSIVG 177
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 178 AICWLCVHfffketlatdkrlklslyqvatlygaifkdaSFRLPMFAGCLTGAALFCYISSAPAVFMDQYGLNQQEFAYV 257
Cdd:cd17321 161 LVALLLAR-------------------------------TFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLA 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 258 FGLNAFGIMLMSSLNKHLTTRVEItKRLKAGSMVqVTGASIVLIAGLISAAPLWLVMLGLFLAISGIGLTGPNAMALAMS 337
Cdd:cd17321 210 LLPLALAMLVAAPLAGRLADRFGP-RLVLVAGLL-LTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALS 287
|
330 340 350
....*....|....*....|....*....|...
gi 491023702 338 KQGA-RAGTASAIMGSMQFACGLLGGVLLNFLI 369
Cdd:cd17321 288 SVPKeKAGAASGILNTARQLGGALGVALLGALL 320
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
15-392 |
7.29e-25 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 104.55 E-value: 7.29e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 15 IMLLALLTALGPLSIDMYLPALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLF 94
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 95 CVLATNEWSLIAARILQALGGCVGVVMARAAIRDRLDVQGSAQAFSSMMIVMGLAPILAPMIGAWILIWFPWQAIFIALS 174
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 175 IVGAICWLCVHFFfketLATDKRLKLSLYQVATLYGAIFKDASFRLPMFAGCLTGAALFCYISSAPAVFMDQYGLNQQEF 254
Cdd:cd17324 161 VLALLAALLLWRL----LPSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 255 AYVFGLNAFGIMLMSSLNKHLttrveiTKRLKAGSMVQVTGASIVLIAGLISAAPLWLVML-GLFLAISGIGLTGPNAMA 333
Cdd:cd17324 237 IGLLLLFGVAGVVGSPLAGRL------ADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLvGLVLWGLGFFAAHSALQT 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 334 LAMSKQGARAGTASAIMGSMQFACGLLGGVLLNFLIWSASLNM-GVMMVLFTLSGFIVVL 392
Cdd:cd17324 311 RVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGvGWVGAALLLLALLLAL 370
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
2-271 |
7.43e-24 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 100.27 E-value: 7.43e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 2 SEQTAQRQYSIGWIMLLALLTALGPLSIDMYLPALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPL 81
Cdd:COG0477 3 STDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 82 YFGLALYAVASLFCVLATNEWSLIAARILQALGGCVGVVMARAAIRDRLDVQGSAQAFSSMMIVMGLAPILAPMIGAWIL 161
Cdd:COG0477 83 LIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 162 IWFPWQAIFIALSIVGAICWLCVhFFFKETLATDKRLKLSLYQVATLYGAIFKDASFRLPMFAGCLTGAALFCYISSAPA 241
Cdd:COG0477 163 AALGWRWIFLINAPLGLLALVLR-LRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLL 241
|
250 260 270
....*....|....*....|....*....|
gi 491023702 242 VFMDQYGLNQQEFAYVFGLNAFGIMLMSSL 271
Cdd:COG0477 242 LLALLLLALLLLLALLLLAALLLLLLLLLL 271
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
35-369 |
2.75e-23 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 100.34 E-value: 2.75e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 35 ALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCVLATNEWSLIAARILQALG 114
Cdd:cd17503 18 ALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 115 GCVGVVMARAAIRDRLDVQGSAQAFSSMMIVMGLAPILAPMIGAWILIWFPWQAIFIALSIVGAICWLCVHFffketlat 194
Cdd:cd17503 98 GGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLAPL-------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 195 dkrLKLSLyqvatlygaiFKDASFRLPMFAGCLTGAALFCYISSAPAVFMDQYGLNQQEFAYVFGLNAFGIMLMSSLNKH 274
Cdd:cd17503 170 ---LDLRL----------FKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGR 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 275 LTTRVEITKRLKAGSMvqVTGASIVLIAGLISAAPLWLVMLGLFLAISGIGLTGPNAMALAMSK-QGARAGTASAIMGSM 353
Cdd:cd17503 237 LLDKFGPRLLLLAGLL--LLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSlPPEQIGDATALFNTI 314
|
330
....*....|....*.
gi 491023702 354 QFACGLLGGVLLNFLI 369
Cdd:cd17503 315 RQLGGSIGTALLATLL 330
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
57-191 |
1.15e-21 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 90.02 E-value: 1.15e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 57 YFFGLAIGQLVYGPLS----DRIGRKKPLYFGLALYAVASLFCVLATNEWSLIAARILQALGGCVGVVMARAAIRDRLDV 132
Cdd:TIGR00880 3 LLAGYALGQLIYSPLSglltDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPP 82
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 491023702 133 QGSAQAFSSMMIVMGLAPILAPMIGAWILIWFPWQAIFIALSIVGAICWLCVHFFFKET 191
Cdd:TIGR00880 83 EERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
14-399 |
1.64e-21 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 94.94 E-value: 1.64e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 14 WIMLLALLTALGPLSIDMYLP--ALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVA 91
Cdd:COG2271 9 WRILALLFLAYFLNYLDRSNLsvAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 92 SLFCVLATNEWSLIAARILQALGGCVGVVMARAAIRDRLDVQGSAQAFSSMMIVMGLAPILAPMIGAWILIWFPWQAIFI 171
Cdd:COG2271 89 TLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 172 ALSIVGAIcwlcvhfffketlatdkrlkLSLYQVATLYGAIFkdasfrlpmfagcLTGAALFCYISSAPAVFMDQYGLNQ 251
Cdd:COG2271 169 ILGLPGLL--------------------LALLRFWLLALAYF-------------LVYFALYGFLTWLPTYLVEVRGLSL 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 252 QEFAYVFGLNAFGIMLMSSLNKHLTTRVeitKRLKAGSMVQVTGASIVLIAGLISAAPLWLVMLGLFLAISGIGLTGPNA 331
Cdd:COG2271 216 AQAGLLLSLPFLAGIVGSLLGGWLSDRL---GRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLL 292
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 332 MALAMSK-QGARAGTASAIMGSMQFACGLLGGVLLNFLIWSASLNMG-VMMVLFTLSGFIVVLKATRQAK 399
Cdd:COG2271 293 WALAAELfPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAfLLLAALALLAALLALLLLRETR 362
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
18-392 |
1.08e-18 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 86.71 E-value: 1.08e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 18 LALLTALGPLSIDMYLPALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCVL 97
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 98 ATNEWSLIAARILQALGGCVGVVMARAAIRDRLDVQGSAQAFSSMMIVMGLAPILAPMIGAWIL--IWFPWQAIFIALSI 175
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 176 VGAICWLCVHFFFKETLATDKRLK--LSLYQVATLYGAIFKDASFRLPMFAGCLTGAALFCYISSAPAVFMDQYGLNQQE 253
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNeeASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 254 FAYVFGLNAFGIMLMSSLNKHLTTRVEITKRLKAGSMVqvtGASIVLIAGLISAAPLWLVMLGLFLAISGIGLTGPNAMA 333
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLL---LMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFAL 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 491023702 334 LAMSKQGARAGTASAIMGSMQFACGLLGGVLLNFLIWSASLNMGVMMVLFTLSGFIVVL 392
Cdd:cd06174 318 IAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAIL 376
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
18-391 |
7.54e-18 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 84.19 E-value: 7.54e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 18 LALLTALGPLSIDMYLPALPQMAHDFGVSTQMVANT-LPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCV 96
Cdd:cd17472 1 LSLIFSLRMLGMFLVLPVLSVYAKSLPGATPTLIGLaLGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 97 LATNEWSLIAARILQALGGCVGVVMARAAIRDRLDVQGSAQAFSSM------MIVMGLAPILAPMIGAwiliwfpwQAIF 170
Cdd:cd17472 81 YATSIYGLILGRALQGSGAISSVVMALLADLTREENRTKAMALIGAsigiafAISMVLGPLLAAHLGV--------SGLF 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 171 IALSIVGAICWLCVHFFFKEtlatDKRLKLSLYQVATLYGAIFKDASFRLPMFAGCLTGAALFCYISSAPAVFMDQYGLN 250
Cdd:cd17472 153 LITAILSLVSLLILLFFVPD----PPKIVQISEKEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGK 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 251 QQEFAYVFGLNAFGIMLMSSLNKHLTtrveitkrlKAGSMVQVTGASIVLIA----GLISAAP-LWLVMLGLFLAISGIG 325
Cdd:cd17472 229 GQLWKVYLPAILIGFILMVPFVIYAE---------KKGKMKQVFVSSILLIAvgflLLLFAATsLWLLIIGLIIFFIGFN 299
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491023702 326 LTGPNAMALA--MSKQGARaGTASAIMGSMQFACGLLGGVLLNFLiWSASLNMGVMMVLFTLSGFIVV 391
Cdd:cd17472 300 LLEALLPSLVskIAPKEYR-GTAMGIYNTSQFLGSFLGGALGGLL-WGLLGYSSVFLTILILALLWLL 365
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
15-388 |
1.30e-17 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 83.40 E-value: 1.30e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 15 IMLLALLTALGPLSIDMYLPALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLF 94
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 95 CVLATNEWSLIAARILQALGGCvGVVMARAAIRDRLDVQGSAQAFSSMMIVMGLAPILAPMIGAWILIWFPWQAIFIALS 174
Cdd:cd17330 81 LGLSRNLWLLFLARFLDGLTGG-NVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 175 IVGAICWLCVHFFFKetlatdkrlklslyqvatlygaifkdaSFRLPMFAGCLTGAALFCYISSAPAVFMDQYGLNQQEF 254
Cdd:cd17330 160 ALALLNLVLVLFFLP---------------------------PLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQI 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 255 AYVFGLNAFGIM-----LMSSLNKHLTTRVEITkrlkAGSMVQVTGASIVLIAGLISAAPLWLVMLGLFLAISGIGLTGP 329
Cdd:cd17330 213 GLLLALVGIAGIlaqllLIPRLAKRLGERKLLR----LGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSAL 288
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491023702 330 NAMALAMSKQGARAGTASAIMGSMQFACGLLGGVLLNFLI--WSASLNMGVMMVLFTLSGF 388
Cdd:cd17330 289 LSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGpgVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
15-392 |
5.98e-17 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 81.47 E-value: 5.98e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 15 IMLLALLTALGPLSIDmylPALPQMAHDF-GVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASL 93
Cdd:cd17473 4 LLLASTLTVMAGAAIA---PALPAIAQHFvPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 94 FCVLATNEWSLIAARILqaLGGCVGVVMAR--AAIRDRLDVQGSAQAFSSMMIVMGLAPILAPMIGAWiLIWFPWQAIFi 171
Cdd:cd17473 81 AGLFLDSLYALLASRAL--LGIGVAGIMTLatALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGA-LAEIGWRAPF- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 172 ALSIVGAICWLCVHFFFKETLATDKRLKLSLYQVAtlygAIFKDASFRLPMFAGCLTGAALFCYISSAPAVFMDQYGLNQ 251
Cdd:cd17473 157 LVYLLALPVLILVLLFLPEPARKSKSAASPGAATA----AALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSA 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 252 QEFAYVFGLNAFGIMLMSSLNKHLTTRVEITKRLKAGSMVQVTGasivlIAGLISAAPLWLVMLGLFLAISGIGLTGPNA 331
Cdd:cd17473 233 ALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALG-----FLLLALASGLWVVLLGAILAGLGFGLLLPTL 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491023702 332 MALAMSKQGARA-GTASAIMGSMQFACGLLGGVLLNFLIWSASLNMGVMMVLFTLSGFIVVL 392
Cdd:cd17473 308 NSWAMSLVPPELrGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIV 369
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
11-392 |
3.04e-16 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 79.54 E-value: 3.04e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 11 SIGWIMLLALLTA--LGPLSIDMYLPALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALY 88
Cdd:COG2223 1 SGRWRVLLLATLAffLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 89 AVASLFCVLATNEWSLIAARILQ--ALGGCVGVVMARAAIRDRLDVQGSAQAFSSMMivMGLAPILAPMIGAWILIWFPW 166
Cdd:COG2223 81 GIGLLLLALAVSYWLLLLLGLLLgiGGGGSFAVGIALVSKWFPPDRRGLALGLAAGG--GNLGAAVAAFLAPLLIAAFGW 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 167 QAIFIALSIVGAICWLCVHFFFKETLATDKRLKlslYQVATLYGAIFKDASFRLPMFAGCLTGAALFCYISSAPAVFMDQ 246
Cdd:COG2223 159 RNAFLILGILLLVVAVLAWLFLRDPPAGAAAAA---KASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQ 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 247 YGLNQQEFAYVFGLNAFGIMLMSSLNKHLTTRVEITKRLKAGSMVQVTGAsivLIAGLISAAPLWLVMLGLFLAISGIGL 326
Cdd:COG2223 236 FGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGL---LLLALALGSLWLFLVLFLLLGLALGGG 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491023702 327 TGPNAMALAMSKQGARAGTASAIMGSMQFACGLLGGVLLNFLIWSASLNMGVMMVLFTLSGFIVVL 392
Cdd:COG2223 313 NGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVL 378
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
27-348 |
3.86e-16 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 79.49 E-value: 3.86e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 27 LSIDMYLPALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCVLATNEWSLIA 106
Cdd:PRK15403 30 LTTDLIQPGIINVVRDFNADVSLAPASVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLI 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 107 ARILQALGGCVGVVMARAAIRDRLDVQGSAQAFSSMMIVMGLAPILAPMIGAWILIWFPWQAIFIALSIVGAICWLCVHF 186
Cdd:PRK15403 110 ARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWKVLFAIIAVMGLIAFVGLLL 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 187 FFKETLATDKRlKLSLYQVATLYGAIFKDASFRLPMFAGCLTGAALFCYISSAPAVFMDQYGLNQQEFAY----VFGLNA 262
Cdd:PRK15403 190 AMPETVKRGAV-PFSAKSVLRDFRNVFRNRLFLTGAATLSLSYIPMMSWVAVSPVILIDAGGMTTSQFAWtqvpVFGAVI 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 263 FGIMLMSSLNKHLTTRVEITKRLKagsmVQVTGASIVLIAGLISAAPLWLVMLGLFLAISGIGLTGPNAMALAMSKQGAR 342
Cdd:PRK15403 269 VANAIVARFVKDPTEPRFIWRAVP----IQLVGLALLIVGNLLWPHVWLWSVLGTSLYAFGIGLIFPTLFRFTLFSNNLP 344
|
....*.
gi 491023702 343 AGTASA 348
Cdd:PRK15403 345 KGTVSA 350
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
14-401 |
4.75e-16 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 79.13 E-value: 4.75e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 14 WIMLLALLTALGPLSIDMYLPALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASL 93
Cdd:COG0738 9 ALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 94 FCVLATNEWSLIAARILQALGGCVGVVMARAAIRDrLDVQGSAQAFSSMMIVMGLAPILAPMIGAWILIW---FPWQAIF 170
Cdd:COG0738 89 LFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAA-LGPETAASRLNLLHAFFSLGALLGPLLGGLLILLglsLSWHLPY 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 171 IALSIVGAICWLcvhFFFKETLATDKRLKLSLYQVATLYGAIFKDASFRLPMFAGCLTGAALFCYISSAPAVFMDQYGLN 250
Cdd:COG0738 168 LILAVLLLLLAL---LFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLS 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 251 QQEFAYVFGLNAFGIMLMSSLNKHLTTRVEITKRLKAGSMVQVTGASIVLIAGLISAAPLWLVMLGLFLAIsgiglTGPN 330
Cdd:COG0738 245 EATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSL-----MFPT 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491023702 331 AMALAMSKQGARAGTASAIMGSMQFACGLLGGVLLNFLIWSASLNMG-VMMVLFTLSGFIVVLKATRQAKSQ 401
Cdd:COG0738 320 IFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAfLVPLVCYLLILLLALALKRKRRKK 391
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
35-369 |
1.80e-15 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 77.23 E-value: 1.80e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 35 ALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCVLATNEWSLIAARILQALG 114
Cdd:cd17319 25 AAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 115 GCVGVVMARAAIRDRLDVQGSAQAFSSMMIVMGLAPILAPMIGAWILIWFPWQAIFIALSIVGAICWLCVHFFFKETLAT 194
Cdd:cd17319 105 EAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQVWGL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 195 dkrlklslyqvatlygaifkdasfrlpMFAGCLTGAALFCYISSAPAVFMDQYGLNQQEFAYV----FGLNAFGIMLMSS 270
Cdd:cd17319 185 ---------------------------ALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLaaipFLAGAIGMILGGR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 271 LNKHLTTRVEitkRLKAGSMVQVTGASIVLIAGLISAaplWLVMLGLFLAISGIGLTGPNAMALAMSK-QGARAGTASAI 349
Cdd:cd17319 238 LSDRLLRGAR---RLVIIIGLLLAAVGLLLAYLTTSP---VVAVILLSLAGFGIGAASPVFWSLPADLlPGEAAATAGGL 311
|
330 340
....*....|....*....|
gi 491023702 350 MGSMQFACGLLGGVLLNFLI 369
Cdd:cd17319 312 INSGGNLGGFVAPLLIGYLV 331
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
31-179 |
6.28e-14 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 72.61 E-value: 6.28e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 31 MYLPALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCVLATNEWSLIAARIL 110
Cdd:cd17504 14 MLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRAL 93
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491023702 111 QALGGCVgVVMARAAIRDRLDVQGSAQAFSSMMIVMGLAPILAPMIGAWILIWFPWQAIFIALSIVGAI 179
Cdd:cd17504 94 QGIGGAV-FPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVL 161
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
63-392 |
2.05e-13 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 71.10 E-value: 2.05e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 63 IGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCVLATNEWSLIAARILQALGGCVGVVMARAAIRDRLDVQGSAQAFSSM 142
Cdd:cd17329 50 VASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLL 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 143 MIVMGLAPILAPMIGAWILIWFPwQAIFIALSIVGAICWLCVHFFFKETLATDKRLKLSLyqVATLYGAIFKDASFRLPM 222
Cdd:cd17329 130 YWAINLGVAIGPLLGGLLLLYSF-RLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTE--ILRGYKIVLRDRAFLLFL 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 223 FAGCLTGAALFCYISSAPAVFMDQYGLNQQEFAYVFGLNAFGIMLMSSLNKHLTTRVEITKRLKAGsmvqVTGASIVLIA 302
Cdd:cd17329 207 LASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIG----ILLFAIGFAV 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 303 GLISAAPLWLVMLGLFLAIsGIGLTGPNAMALA--MSKQGARAGTASAIMGSMQFAcGLLGGVLLNFLIWSASLNMGVMM 380
Cdd:cd17329 283 LAFANTLAVLILAMIVLTL-GEMLVFPAVQTLVaaLAPPDKRGSYMGFYALAWGLG-RAIGPLVGGLLLDLLGPGLPWLI 360
|
330
....*....|..
gi 491023702 381 VLFTLSGFIVVL 392
Cdd:cd17329 361 LAALGLIAAALL 372
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
18-392 |
3.41e-13 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 70.32 E-value: 3.41e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 18 LALLTALGPLSIDMYLPALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCVL 97
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 98 ATNEWSLIAARILQALGGCVGVVMARAAIRDRLDVQGSAQAFSSMMIVMGLAPILAPMIGAWILIWFPWQAIFIALSIVG 177
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 178 AICWLCVhFFFKETLATDKRLKlslyQVATLYGAIFKDASFRLPMFAgCLTGAALFCYISSAPAVFMDQYGLNQqeFAYV 257
Cdd:cd17489 161 LLALLLV-FLVKDPPPVAAEEA----EAGTRAFRRLVEKKVLPPALI-LFLASIAYGAISTFLPLYAAERGISN--AGLF 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 258 FGLNAFGIMLMSSLNKHLTTRVEITKRLKAGSMVQVTGasivlIAGLISAAPLWLVMLGLFLAISGIGLTGPNAMALAMS 337
Cdd:cd17489 233 FTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALG-----LLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVD 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 491023702 338 KQGA-RAGTASAIMGSMQFACGLLGGVLLNFLIWSASL-NMGVMMVLFTLSGFIVVL 392
Cdd:cd17489 308 LVPPhRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYrAMFLLAAVVVLLALVLYI 364
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
31-392 |
1.13e-12 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 68.87 E-value: 1.13e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 31 MYLPALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCVLATNEWSLIAARIL 110
Cdd:cd17371 17 LLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 111 QALGGC----VGVVMARAAI--RDRLDVQGSAQAFSSmmIVMGLAPILAPMIGAWILIWFPWQAIFIALSIVGAICWLcV 184
Cdd:cd17371 97 AGLGFGgewaAGAALMAEYVpaRHRGKALGYVQSGWA--VGWLLATLLAALLFPLLPPEIAWRVLFLLGALPALLVLF-I 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 185 HFFFKET-LATDKRLKLSLYQVATLYGAIFKDASFRLPMFAGCLTGAALFCYISSA---PAVFMDQYGLNQQEFAYVFGL 260
Cdd:cd17371 174 RRFVKEPpQWQAARAARRHFADRPSLRELFSPPLLRTTLLASLLATGALGGYYGITtwlPSYLTGERGLSFEGSAGYLVV 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 261 NAFGIMLMSSLNKHLTTRVEITKRLKAGSMvqVTGASIVLIAGLiSAAPLWLVMLGLFLAISGIGLTGPNAMALAMSKQG 340
Cdd:cd17371 254 TILGGFLGYLAGGFLADRIGRRNNFALFAL--GSAISILLYFFL-PLSPTLILILGFPLGFFASGPFSGMGAYLTELFPT 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 491023702 341 ARAGTASAIMGSMQFACGLLGGVLLNFLiwSASLNMGVMMVLFTLSGFIVVL 392
Cdd:cd17371 331 AVRATAQGFCYNVGRIIGALFPFLVGFL--ATSGSLGTAIAVFAAVYYIAGL 380
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
12-197 |
2.67e-12 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 67.66 E-value: 2.67e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 12 IGWIMLLALLTALGplsIDMYLPALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGP----LSDRIGRKKPLYFGLAL 87
Cdd:cd17388 1 LIFILVTVLLDAMG---IGLIMPVLPTLLREFVGDSADAATHYGVLLALYALMQFIFAPilgaLSDRFGRRPVLLLSLAG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 88 YAVASLFCVLATNEWSLIAARILQALGGCVGVVmARAAIRDRLDVQGSAQAFSSMMIVMGLAPILAPMIGAWiLIWFPWQ 167
Cdd:cd17388 78 AALDYLLMAFAPTLWWLYLGRIIAGITGATGAV-AAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGL-LGEISPR 155
|
170 180 190
....*....|....*....|....*....|
gi 491023702 168 AIFIALSIVGAICWLCVHFFFKETLATDKR 197
Cdd:cd17388 156 APFLVAAGLNGLNFLLGLFVLPESLPPERR 185
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
15-184 |
1.07e-11 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 65.68 E-value: 1.07e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 15 IMLLALLTALGPLSIDMYLPALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLF 94
Cdd:cd17365 1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 95 CVLATNEWSLIAARILQALGgcVGVVMARAA--IRDRLDVQGSAQAFSSMMIVMGLAPILAPMIGAWILIWFPWQAIFIA 172
Cdd:cd17365 81 TAFAQSVLQLALLRFLTGLG--LGAAMPNAItlVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLL 158
|
170
....*....|..
gi 491023702 173 LSIVGAICWLCV 184
Cdd:cd17365 159 GGVPPLILLPLL 170
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
35-188 |
1.40e-11 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 65.28 E-value: 1.40e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 35 ALPQMAHDFGvSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCVLATNEWSLIAARILQALG 114
Cdd:cd17502 18 ALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIG 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 115 GCVGVVMARAAIRD--RLDVQGSAQAFssMMIVMGLAPILAPMIGAWILIWFPWQAIF--------IALSIVGAICWLCV 184
Cdd:cd17502 97 GGGLMSLAFIIIADlvPPRERGKYQGY--IGAVFGIASVAGPLIGGAFTDHLSWRWCFyinlpiggLALALLRTILLSSI 174
|
....
gi 491023702 185 HFFF 188
Cdd:cd17502 175 FGFL 178
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
35-190 |
1.77e-11 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 65.48 E-value: 1.77e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 35 ALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCVLATNEWSLIAARILQALG 114
Cdd:TIGR00711 24 AIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFG 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491023702 115 GCVGVVMARAAIRDRLDVQGSAQAFSSMMIVMGLAPILAPMIGAWILIWFPWQAIFIALSIVGAICWLCVHFFFKE 190
Cdd:TIGR00711 104 GGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVVAFFILPR 179
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
34-402 |
3.06e-11 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 64.51 E-value: 3.06e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 34 PALPQMAHDFGVSTQMVA--NTLPayFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCVLATNEWSLIAARILQ 111
Cdd:COG2807 39 PLLPEIRADLGLSATQAGllTTLP--LLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALI 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 112 ALGGCVGVVMARAAIRDRLDvQGSAQAFSSMMIVMGLAPILAPMIGAWILIWFPWQAIFIALSIVGAICWLCVHFFFKET 191
Cdd:COG2807 117 GAGIAVGNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRR 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 192 LATDKRLklslyQVATLYGAIFKDASFRLPMFAGCLTGAALFCYISSAPAVFMDQyGLNQQEFAYVFGLNAFGIMLMSSL 271
Cdd:COG2807 196 PAAAAAA-----PAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDA-GLSAATAGLLLSLFQLAGIPGSLL 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 272 NKHLTTRVEITKRLKAGSMVQVTGASIVLIAGLISAAPLWLVMLGLflaisGIGLTGPNAMALAM--SKQGARAGTASAI 349
Cdd:COG2807 270 VPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGL-----GQGGLFPLALTLIGlrARTPAEAAALSGM 344
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 491023702 350 MGSMQFACGLLGGVLLNFLI-----WSASLnmgVMMVLFTLSGFIVVLKATRQAKSQA 402
Cdd:COG2807 345 AQSVGYLLAALGPLLVGALHdatgsWTAAL---LLLAALAVLMLVAGLLAGRPYVEDA 399
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
35-193 |
3.23e-11 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 64.30 E-value: 3.23e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 35 ALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCVLATNEWSLIAARILQALG 114
Cdd:TIGR00895 39 AAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLG 118
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491023702 115 GCVGVVMARAAIRDRLDVQGSAQAFSSMMIVMGLAPILAPMIGAWILIWFPWQAIFIALSIVGAICWLCVHFFFKETLA 193
Cdd:TIGR00895 119 LGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESID 197
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
34-373 |
6.86e-10 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 60.33 E-value: 6.86e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 34 PALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCVLATNEWSLIAARILQ-A 112
Cdd:cd17475 17 ALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVgA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 113 LGGCVGVVMARAAIRDRLDVQ-GSAQAFSSMMIVMGlaPILAPMIGAWILIWFPWQAIFIALSIVGAICWLCVHFFFKET 191
Cdd:cd17475 97 GYGSVQPGGGRAIMRWFPPRErGLAMGIRQTGVPLG--GALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 192 LATdKRLKLSLYQVATLYGAIFKDASFRLPMFAGCLTGAALFCYISSAPAVFMDQYGLNQQEFAYVFGLNAFGIMLMSSL 271
Cdd:cd17475 175 PAA-SAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIG 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 272 NKHLTTRVEITKRLKA-GSMVQVTGASIVLIAGLISAAPLWLVMLGLFLA-ISGIGLTGPNAMALAMSKQGARAGTASAI 349
Cdd:cd17475 254 LGRVSDRVFGGRRRPVlVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLgLFAIGWNGLYLTLVAESAGPEQAGTALGL 333
|
330 340
....*....|....*....|....
gi 491023702 350 MGSMQFACGLLGGVLLNFLIWSAS 373
Cdd:cd17475 334 ANTINFIGIAIGPPLFGLLVDATH 357
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
35-193 |
1.07e-08 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 56.41 E-value: 1.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 35 ALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCVLA--TNEWSLIAARILQA 112
Cdd:cd17380 21 AIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLaySSLPLLILSRILLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 113 LGGCVGVVMARAAIRDRLDVQGSAQAFSSMMIVMGLAPILAPMIGAWILIWFPWQAIFIALSIVGAICWLCVHFFFKETL 192
Cdd:cd17380 101 LGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYLPPVW 180
|
.
gi 491023702 193 A 193
Cdd:cd17380 181 A 181
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
35-186 |
1.47e-08 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 56.04 E-value: 1.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 35 ALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCVLATNEWSLIAARILQALG 114
Cdd:cd17359 23 ALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 115 -GCVGVV-------MARAAIRdrldvqGSAQAFSSMMIVMGLAP------ILAPMIGAWILIWFPWQAIFIALSIVGAIC 180
Cdd:cd17359 103 vGGASALvpmyiaeVAPAEIR------GRLVSLNQLMIVFGQLLayivnyLIANAGGADWLGAEGWRWMLGLEAIPAILF 176
|
....*.
gi 491023702 181 WLCVHF 186
Cdd:cd17359 177 LLGMLF 182
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
60-364 |
2.16e-08 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 55.63 E-value: 2.16e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 60 GLAIGQLVyGPLSDRIG-RKKPLYFGLALYAVASLFCVLATNEWSLIAARILqaLGGCVGVVMAR--AAIRDRLDVQGSA 136
Cdd:cd17471 45 GIVVSQWL-GRLSDRGGdRKPLILLALLAGALGYLLFAFLRNYWVLLLVGVV--LLSLGAAAFPQlfALAREYADRSSGR 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 137 QA---FSSMMIVMGLAPILAPMIGAWILIWFPWQAIFIALSIVGAICWLCVHFFFKetlatDKRLKLSLYQVATLYGAIF 213
Cdd:cd17471 122 DAtlfNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLP-----SVKPPAQKATPASSLVKAP 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 214 KDASFRLPMFAGCLTGAALFCYISSAPAVFMDQYGLNQQEFAYVFGLNAF---GIMLMSSLnkhLTTRVEITKRLKAGSM 290
Cdd:cd17471 197 VNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGLLFGLAAAleiPIMLLAGL---LAKRFGKRRLLLAGFL 273
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491023702 291 vqvtgASIVLIAGLISAAPLWLVMLGLFLAISGIGLTGPNAMALAMSKQGARAGTASAIMGSMQFACGLLGGVL 364
Cdd:cd17471 274 -----AGVLFYLGLALATSLWQLIALQLLNAIFIGITAGLGISYFQDLMPGQPGLATTLYSNASRIGSLLGGLL 342
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
35-184 |
8.86e-08 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 53.97 E-value: 8.86e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 35 ALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCVLATNEWSLIAARILQALG 114
Cdd:PRK10504 32 ALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARVLQGVG 111
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491023702 115 GCVGVVMARAAIrdrLDVQGSAQAFSSMMIVM---GLAPILAPMIGAWILIWFPWQAIF---IALSIVGAICWLCV 184
Cdd:PRK10504 112 GAMMVPVGRLTV---MKIVPREQYMAAMTFVTlpgQVGPLLGPALGGLLVEYASWHWIFlinIPVGIIGAIATLML 184
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
136-392 |
1.51e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 52.98 E-value: 1.51e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 136 AQAFSSMMIVMGLAPILAPMIGAWILIWFP------WQAIFIALSIVGAICWLCVHFFFKETLATDKRlKLSLYQVatlY 209
Cdd:COG2211 146 TRLSSWRFAFAGLGGLLASVLPPPLVAAFGgdaalgYRLTALIFAVLGLLAFLLTFFGTKERPVPEEE-KVSLKES---L 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 210 GAIFKDASFRLPMFAGCLTGAALFCYISSAPAVFMDQYGLNQQEFAYVFGLNAFGIMLMSSLNKHLTTRVEitkrlKAGS 289
Cdd:COG2211 222 KALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFG-----KKKA 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 290 MVQVTGASIVLIAGLISAAPLWLVMLGLFLAISGIGLTGPNAMALAM---------SKQGAR-AGTASAIMGSMQFACGL 359
Cdd:COG2211 297 FIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMladvvdydeWKTGRRrEGLYFGIFTFAIKLGQA 376
|
250 260 270
....*....|....*....|....*....|...
gi 491023702 360 LGGVLLNFLIWSASLNMGVMMVLFTLSGFIVVL 392
Cdd:COG2211 377 LAGALAGLLLALFGYVAGAAQSPSALTGIRLLF 409
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
35-114 |
1.64e-07 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 53.04 E-value: 1.64e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 35 ALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCVLATNEWSLIAARILQALG 114
Cdd:PRK11551 37 AAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVG 116
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
31-385 |
3.72e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 51.85 E-value: 3.72e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 31 MYLPALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCVLAT-----NEWSLI 105
Cdd:cd06173 17 IFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLAllgslSLWLLL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 106 AARILQALGGCVGVVMARAAIRDRLDVQGSAQAFSSMMIVMGLAPILAPMIGAWILIWFPWQAIFIALSIVGAICWLCVH 185
Cdd:cd06173 97 VLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 186 FFFKETLATDKRLKLSLYQVATLYGAIFKDASFRLP-MFAGCLTGAALFCYISSAPAVFMDQYGLNQQEFAYVFGLNAFG 264
Cdd:cd06173 177 FIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLlLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 265 IMLMSSLNKHLTTRVEITKRLKAGSMVQVtgasiVLIAGLISAAPLWLVMLGLFLAISGIGLTGPNAMALAMSK-----Q 339
Cdd:cd06173 257 ALLGALLLGRLSKRRRRGRLLLIGALLLG-----LALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRvpdelR 331
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 491023702 340 GARAGTASAIMGSMQFACGLLGGVLLNFLIWSAS-LNMGVMMVLFTL 385
Cdd:cd06173 332 GRVFSVYNALNSGAMPLGALLAGLLADALGLSAVfLLAGALLLLAAL 378
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
34-392 |
3.75e-07 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 51.51 E-value: 3.75e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 34 PALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCVLATNEWSLIAARILQAL 113
Cdd:cd17312 24 VAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 114 GGCVGVVMARAAIRDRLDVQGSAQAFSSMMIVMGLAPILAPMIGAWILIWFPWQAIFIALSIVGAICWLCVHFFFKETLA 193
Cdd:cd17312 104 FQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDSPP 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 194 TdkrlklsLYQVATLYGAIFkdasfrlPMFAGCLTGAALFCYissapavfmDQYGLNQQEFAYVFGLNAFGIMLMSSLNK 273
Cdd:cd17312 184 Y-------VWVLSLAYAFVY-------IVRYACLDWGPLYLY---------EVKGYSLIDAGWFSSLYEVGGIAGTILAG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 274 HLTTRVEITKRLKagsMVQVTGASIVLIAGLISAAPLWLVMLGLFLAISGIGLTGPNAM-ALAMSKQGAR---AGTASAI 349
Cdd:cd17312 241 LLSDKLFGGRRAP---IAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLIGFFVGGPINLiGGAAAQDIGRkeaAGTATGF 317
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 491023702 350 MGSMQFACGLLGGVLLNFLIwSASLNMGVMMVLFTLSGFIVVL 392
Cdd:cd17312 318 VGLFGYLGASLAGLPLGYII-DHYGWSTVFYFLISAALLSVLL 359
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
13-364 |
3.84e-07 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 51.89 E-value: 3.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 13 GWIMLLAL-LTALGPLSIDMYLPALPQ-MAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAV 90
Cdd:cd17355 1 GWVVLAVTfLILILSWGIRYYFGVFIIpIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 91 ASLFCVLATNEWSLIAARILQALGGCVGVVMAR-AAIRDRLDVQGSAQAFSSMMIVMGLAPILAPMIGAWILIWFPWQAI 169
Cdd:cd17355 81 GLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAfATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 170 FIALSIVGAICWLCVHFFF---KETLATDKRLKLSLYQVATLYGAIFKDASFRLPMFAGCLTGAALFCYISSAPAvFMDQ 246
Cdd:cd17355 161 LLVLALLALLVLVPVLLLLrrrPADLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVP-YLAD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 247 YGLNQQEFAYVFGLNAFGIMLMSSLNKHLTTRVEITKRLKAGSMVQVTGASIVLIAGlisAAPLWLVMLGLFLAISGIGL 326
Cdd:cd17355 240 RGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLP---FPPLALLLFAALFGLGWGAT 316
|
330 340 350
....*....|....*....|....*....|....*...
gi 491023702 327 TGPNAMALAMSKQGARAGTasaiMGSMQFACGLLGGVL 364
Cdd:cd17355 317 VPLTAALAARYFGARSYGT----LFGLVFAPHQLGSAL 350
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
18-392 |
4.83e-07 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 51.41 E-value: 4.83e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 18 LALLTALGPLSIDMYLPALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCVL 97
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 98 ATNEWSLIAARILQALGGCVGVVMARAAIRDRLDVQGSAQAFSSMMIVMGLAPILAPMIGAWILIwFPWQAiFIALSIVG 177
Cdd:cd17477 81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGT-AGALP-FLIAAVLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 178 AICWLCVHFFFKETLATDKRLKLSLYQVATLygaifkdasFRLPMFAGCLTGAALFCYISSAPaVFMDQYGLNQQEFAYV 257
Cdd:cd17477 159 LLALVPLLLTRRAAPEIEEAESISLRRLLRI---------APLALLGAFVAGFLEGAFYSLLP-LYGLRLGLSVAQAALL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 258 FGLNAFGIMLMSSLNKHLTTRVEitkrlKAGSMVQVTGASIVLIAGLISAAPLWLVMLGLFLAISG-IGLTGPNAMALAM 336
Cdd:cd17477 229 LAAFVLGGLLLQWPLGWLADRFD-----RRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGaAGPLYTLALALAG 303
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 491023702 337 SK-QGARAGTASAIMGSMQFACGLLGGVLLNFLIWSASLNmGVMMVLFTLSGFIVVL 392
Cdd:cd17477 304 DRlPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPH-GLFLFLAAVALLFLLF 359
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
35-122 |
1.29e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 49.91 E-value: 1.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 35 ALPQMAHDF--GVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCVLATNEWSLIAARILQ- 111
Cdd:cd17316 21 VAPVLAAEFslGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQg 100
|
90
....*....|..
gi 491023702 112 -ALGGCVGVVMA 122
Cdd:cd17316 101 iGIGGEYPGAST 112
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
14-183 |
2.80e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 49.13 E-value: 2.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 14 WIMLLALLTALGPLSIDMYLPALpqMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASL 93
Cdd:COG2211 232 LLLLAYLLFFLALALVAALLLYY--FKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLL 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 94 FCVLA--TNEWSLIAARILQALGGCVGVVMARAAIRDRLDVQ---------GSAQAFSSMMIVMGLApiLAPMIGAWILI 162
Cdd:COG2211 310 LLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDewktgrrreGLYFGIFTFAIKLGQA--LAGALAGLLLA 387
|
170 180 190
....*....|....*....|....*....|..
gi 491023702 163 WFPWQA-----------IFIALSIVGAICWLC 183
Cdd:COG2211 388 LFGYVAgaaqspsaltgIRLLFFLLPAVLLLL 419
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
36-369 |
3.76e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 48.47 E-value: 3.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 36 LPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVAsLFCVLATNEWSLIAARILQAlGG 115
Cdd:cd17333 19 GPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLA-LALIFATPSIYLFVVLMFLA-GL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 116 CVGVVMARA-AIRDRLDVQGSAQAFSSMMIVMGLAPILAPMIGAWILIW-FPWQAIFI---ALSIVGAICWLCVHFFFKE 190
Cdd:cd17333 97 GAGILDTGAnTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSeLSWSWAYLiigLIYLLLAILILLTLFPELP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 191 tlatdkrlklSLYQVATLYGAIFKDASFRLPMFAGCLTGAALFCYISS-------APAVFMDQYGLNQQEFAYVFGLNAF 263
Cdd:cd17333 177 ----------SARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAetafsswVPSYLVEKKHVSDGLAGYLLSGFWV 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 264 GIMLMSSLNKHLTTRVEITKRLkagsMVQVTGASIVLIAGLISAAPLWLVMLGLFLAIsGIGLTGPNAMALAMSkqgaRA 343
Cdd:cd17333 247 GITIGRLLGGPISRRIKPHTLL----VLSGSGALLGLLILLLAPTLVVGLVATALLGL-FMAALFPTILSLGIS----NL 317
|
330 340
....*....|....*....|....*.
gi 491023702 344 GTASAIMGSMQFACGLLGGVLLNFLI 369
Cdd:cd17333 318 PYAKGKGTSVLLAAGSIGGAIIPFIM 343
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
35-122 |
6.50e-06 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 48.16 E-value: 6.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 35 ALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCVLATNEWSLIAARIlqalg 114
Cdd:PRK03893 42 VLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARL----- 116
|
....*...
gi 491023702 115 gCVGVVMA 122
Cdd:PRK03893 117 -VIGMGMA 123
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
58-193 |
1.09e-05 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 47.18 E-value: 1.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 58 FFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCVLATNEWSLIAARILQALG-GCVGVV-------MARAAIRdr 129
Cdd:cd17315 44 LLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGvGLASVLvplyiseIAPAKIR-- 121
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491023702 130 ldvqGSAQAFSSMMIVMGLapILAPMIG-AWILIWFPWQAIFIALSIVGAICWLCVHFFFKETLA 193
Cdd:cd17315 122 ----GALGTLNQLMITFGI--LLAYLLGlALSLSPPGWWRLMFALAAVPALLQLLLMFFLPESRA 180
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
14-201 |
1.26e-05 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 47.03 E-value: 1.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 14 WIMLLALLTALGPLSIDMYL--PALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVA 91
Cdd:PRK14995 5 WLTLVIIVLVYIPVAIDATVlhVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 92 SLFCVLATNEWSLIAARILQALGGCVGVVMARAAIRDR-LDVQGSAQAFSSMMIVMGLAPILAPMIGAWILIWFPWQAIF 170
Cdd:PRK14995 85 SLAAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATfTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVF 164
|
170 180 190
....*....|....*....|....*....|..
gi 491023702 171 -IALSIVGAICWLCVHFFFKETLATDKRLKLS 201
Cdd:PRK14995 165 lINVPIVLVVMGLTARYVPRQAGRRDQPLNLG 196
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
56-114 |
1.79e-05 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 46.50 E-value: 1.79e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491023702 56 AYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCVLATNEWS---LIAARILQALG 114
Cdd:pfam00083 54 IFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSvyqLIVGRVLVGIG 115
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
15-389 |
2.09e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 46.38 E-value: 2.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 15 IMLLALLTALGPLSIDMYLPALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPL-YFGLALYAVASL 93
Cdd:cd17370 1 VWLLGLVSLFADISYEMARSILPLFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLvILGYGLSALAKP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 94 FCVLATNEWSLIAARILQALGGCVgvvmaRAAIRDRL-----DVQGSAQAFSSMMIVMGLAPILAPMIGAWILIWFPW-- 166
Cdd:cd17370 81 LLALAGSWQLVLLLRILERLGKGI-----RTPPRDALladatPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLGGny 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 167 QAIFIALSIVGAICWLCVHFFFKETLATDKRLKLSLYQVATLYGAIFKDASFRLPMFAGCLTGAALFCY----------- 235
Cdd:cd17370 156 RTIFLLAAIPALLALLILLFVVKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVALFALGNFSFAFLILraqelglsaal 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 236 ISSAPAVFMDQYGLnqqeFAYVFGlnafgimlmsslnkHLTTRVEITKRLKAGSMvqVTGASIVLIAGLISAAPLWLVML 315
Cdd:cd17370 236 IPLLYALFNLVYAL----AAYPAG--------------RLSDRIGRKKLLILGYL--SLALAYLGFALGSSLWLLLLGFI 295
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 491023702 316 GLFLAIsGIGLTGPNAMALAMSKQGARA---GTASAIMGSMQFACGLLGGVLLNFLIWSASLNMGVMMVLFTLSGFI 389
Cdd:cd17370 296 LWGLYM-GAQESIERAAVADLVPAELRGtayGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
11-184 |
4.11e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 45.24 E-value: 4.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 11 SIGWIMLLALLTALGPLSIDMYLPalpQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAV 90
Cdd:cd17478 196 ALLLLLIIVFLRSWVLSSLTTFLP---FYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAP 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 91 ASLFCVLATNEWSLIAARILQAL---GGCVGVVMARAAIRDRLdvqGSAQAFsSMMIVMGLAPILAPMIGaWILIWFPWQ 167
Cdd:cd17478 273 FLLLFLLTPGIWSYILLVLAGFLlfaSFPVTVVLAQELLPGNV---GLASGL-MMGLSFGLGGIGAPVLG-ALADAFGLE 347
|
170
....*....|....*..
gi 491023702 168 AIFIALSIVGAICWLCV 184
Cdd:cd17478 348 SVLLILALLPLLGALLA 364
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
15-180 |
4.47e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 45.30 E-value: 4.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 15 IMLLALLTALGPLSIDMYLPALPQMAHD-FGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASL 93
Cdd:cd06173 210 LRLLLLALALFALLGGALTVLLPLLAKEvLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALL 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 94 FCVLATNEWSLIAARILQALGGCVGVVMARAAIRDRLDVQGSAQAFSSMMIVMGLAPILAPMIGAWILIWFPWQAIFIAL 173
Cdd:cd06173 290 VLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLA 369
|
....*..
gi 491023702 174 SIVGAIC 180
Cdd:cd06173 370 GALLLLA 376
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
36-187 |
4.53e-05 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 45.08 E-value: 4.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 36 LPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCVLATNEWSLIAARILQAL-- 113
Cdd:PRK10091 26 LTELAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIGNAMFTLSSSYLMLAIGRLVSGFph 105
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491023702 114 GGCVGVvmaRAAIRDRLDVQG-SAQAFSSMMIVMGLAPILAPMIGAWILIWFPWQAIFIALSIVGAICWLCVHFF 187
Cdd:PRK10091 106 GAFFGV---GAIVLSKIIKPGkVTAAVAGMVSGMTVANLLGIPLGTYLSQEFSWRYTFLLIAVFNIAVLASIYFW 177
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
43-188 |
5.92e-05 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 44.93 E-value: 5.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 43 FGVSTQMVANTLPAYFFGLAIGQ-LVYGPLSDRIGRKKPLYFGLALYAVASLFCVLATNEWSLIAARILQALGGCVGVVM 121
Cdd:cd17388 237 FDWSPTMVGLSLAVFGLLHALFQaFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALGGIAGPAL 316
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 122 aRAAIRDRLDVQGSAQAFSSMMIVMGLAPILAPMIGAWILIWFPWQ---AIFIALSIVGAICWLCVHFFF 188
Cdd:cd17388 317 -QGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAASPATwpgLAWIIGAALYLICLVLAYRFF 385
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
34-385 |
1.14e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 43.78 E-value: 1.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 34 PALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCVLA-TNEWSLIAARILQA 112
Cdd:cd17341 20 PLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAvSSYWGLLVLGFLLG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 113 LGGC---VGVVMARAAIRDRLDVQGSAQAFSSMMIVMGLAPILAPMIGAWILIWFP---WQAIFIALSIVGAICWLCVhF 186
Cdd:cd17341 100 FAGAnfaSGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAIVFDGGfvgWRNAFFVPGILLAIAAVLV-L 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 187 FFKETLATDKRLKLSLyqVATLYGAIFKDASFRLPMFAGCLTGAALfCYISSAPAVFMDQYGLNQQE---FAYVFGLNAF 263
Cdd:cd17341 179 LFGDDLPTGKASALEF--LKVQLAVLKNYRTWILSLLYGVTFGSFV-GFSNVLPTYFKTRFGLPLVTagiLAALFPLAGA 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 264 gimLMSSLNKHLTTRVEITKRLKAGSMVQVTGASIVLIAGLISAAPLWLVMLGLFLAISGIGLTGPNAMALAMSKQGARA 343
Cdd:cd17341 256 ---LARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALGLGAGAGNGSVFRMVPFIFRREL 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 491023702 344 GTASAIMGSMqfacGLLGGVLLNFLIWSASLN----------MGVMMVLFTL 385
Cdd:cd17341 333 GAVTGLVGAI----GGLGGFFLPLLFGSSALMtgsgvgafslFGVLAVACTL 380
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
49-237 |
2.10e-04 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 42.95 E-value: 2.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 49 MVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCVLATNEWSLIAARILQALGgCVGVVMARAAIRD 128
Cdd:cd17317 26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVT-SAGIFTVGFVLGM 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 129 RLdVQGSAQAFSSMMIVMGLApiLAPMIGAWILIWFP-WQAIFIALSIVGAI----CW------LCVHF----------- 186
Cdd:cd17317 105 EI-VGPKYRSFVGILFGLFWA--LGYMLLALLAYLIRdWRWLQLAISLPGLLflllLWwlprrtIIVGLiwfvtslvyyg 181
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 491023702 187 --FFKETLATDKRLKLSLYQV----ATLYGAIFKDASFRLPMFAGCLTGAALFCYIS 237
Cdd:cd17317 182 lsLNSSNLGGNLYLNFFLSGLveipAYFLALLLLDRLGRRWTLSGSLLLAGLACLVT 238
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
18-197 |
3.12e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 42.59 E-value: 3.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 18 LALLTALGPLSIDMYLPALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYF-GLALYAVASLFCV 96
Cdd:cd17490 1 FLIIVFLFWFSQYVYVPFLSPYAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIiGLLFTVLASLIMI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 97 LATNEWSLIAARILQALGGCVGVV--MARAAIRDRLDvqgSAQAFSSMMIVMGLAPILAPMIGAWILIWFPWQAIFIaLS 174
Cdd:cd17490 81 LFPSPWGLLIARFLSGIAAATWVSftVLYASYFPPDE---AAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFL-LA 156
|
170 180
....*....|....*....|...
gi 491023702 175 IVGAICWLCVHFFFKETLATDKR 197
Cdd:cd17490 157 ALAGVLGFILSLFIKEERREKKP 179
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
29-190 |
5.48e-04 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 41.84 E-value: 5.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 29 IDMYLPA--LPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCVLATNEWSLIA 106
Cdd:cd17328 13 MDRFTIAgvLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 107 ARILQALGGCVGVVMARAAIRDRLDVQ--GSAQAFSSMMIVMG--LAPILAPMIGAWILiwfPWQAIFIALSIVGAICWL 182
Cdd:cd17328 93 FRALVGIGEASYSPIAPTIIADLFPKEkrTRALGVFYFAIPLGsgLGYVVGGLVAQATG---GWRWAFRVTGVLGVLLAI 169
|
....*...
gi 491023702 183 CVHFFFKE 190
Cdd:cd17328 170 LLLLFVRE 177
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
35-179 |
6.23e-04 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 41.59 E-value: 6.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 35 ALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCVLATNEWSLIAAR----IL 110
Cdd:TIGR00881 17 AMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWalngIF 96
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491023702 111 QALGG--CVGVVMARAAIRDRldvqGSAQAFSSMMIVMGLApILAPMIGAWILIWFPWQAIFIALSIVGAI 179
Cdd:TIGR00881 97 QGMGWppCGRTVTKWFSRSER----GTWVSFWNCSHNVGGG-LLPPLVLFGIAELYSWHWVFIVPGIIAII 162
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
35-119 |
9.33e-04 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 41.10 E-value: 9.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 35 ALPQMAHDFGV---STQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCVLATNEWSLIAARILQ 111
Cdd:cd17360 19 ALLYIKDDLGEvvlSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLV 98
|
....*...
gi 491023702 112 ALGgcVGV 119
Cdd:cd17360 99 GLG--VGI 104
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
27-382 |
1.31e-03 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 40.67 E-value: 1.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 27 LSIDMYLPALPQMAHDFGVSTQMVANTLPAYffglAIGQLVYGP----LSDRIGRKKPLYFGLALYAVASLFCVLATNEW 102
Cdd:cd17390 10 FGVSMILPLLSTHIRSLGASPTVIGLIGSVY----GALQLFSSPlvgsWSDVVGRRPVLLICLLLTALGYVLLGFSTSLA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 103 SLIAARILqalggcVGVV-----MARAAIRDRLDVQGSAQAFSSMMIVMGLAPILAPMIGAWILIWFPWQAifialsIVG 177
Cdd:cd17390 86 LLFLSRIP------LGIFkhtqsLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDGGFY------YVA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 178 AICWLCvhFFFKETLAtdkrlklslYQVATLYGAIFkdaSFRLPMfagcltGAALFCYISSAPAVFMDQYGLNQQEFAYV 257
Cdd:cd17390 154 LLCSAI--FILNAGLV---------WFLLSKLWDLL---LVRFLM------GFSVLLFRSNFSLYLEERFDLSPKTIGYL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 258 FGLNAFgimlMSSLNKHLTTRveITKRLKAGSMVQVTGASIVL---IAGLISAAPLWLVMLGL-FLAIS-GIGLTGPNAM 332
Cdd:cd17390 214 ISYSGV----LGALSGFLVGR--ILKLYKNNEYLLLLHSFILLalsLLGLALAPSIWLLVLCLtPLSISsAVLRTCSTSL 287
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 491023702 333 ALAMSKQGARA---GTASAIMGSMQFACGLLGGVLLNFLIWSASLnMGVMMVL 382
Cdd:cd17390 288 LLSRGKSKERGtllGVGQSVTSLARILAPLLSGLLQEFSVSGPGL-LGAVLAL 339
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
34-188 |
1.80e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 40.30 E-value: 1.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 34 PALPQMAHDFGVSTQmVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCVLATNEWSLIAARILQAL 113
Cdd:cd06179 19 AVLPFIVADLGPSSN-STWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGI 97
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 491023702 114 GGcVGVVMARAAIRDRLDVQGSAQAFSSMMIVMGLAPILAPMIGAWILIWFP--WQAIFIALSIVGAICWLCVHFFF 188
Cdd:cd06179 98 GA-GTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAagWRWIFYINAIFNALALILLFFFY 173
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
58-190 |
1.94e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 39.94 E-value: 1.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 58 FFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCVLATNEWSLIAARILQ-ALGGCVGVVMARAAIRDRLDVQGSA 136
Cdd:cd17391 46 FLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQgVFSGYVPNATALIASQTPKEKSGWA 125
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 491023702 137 QAFSSMMIVMGLapILAPMIGAWILIWFPWQAIFIALSIVGAICWLCVHFFFKE 190
Cdd:cd17391 126 LGTLSTGVVAGT--LIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLFFVKE 177
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
58-191 |
2.43e-03 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 39.87 E-value: 2.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 58 FFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCVLATNEWSLIAARILQALGG---CVGVVMARAAIRDRlDVQG 134
Cdd:cd17358 51 TLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGgaaSVVVPVYIAEIAPK-NVRG 129
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 491023702 135 SAQAFSSMMIVMGLapILAPMIGAWIliwfPWQAIFIALSIVGAICWLCVhFFFKET 191
Cdd:cd17358 130 ALGSLNQLLVNIGI--LLGYVLGSFL----PWRTLALIGAIPPVVFLILL-FFIPES 179
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
49-114 |
4.05e-03 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 39.23 E-value: 4.05e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491023702 49 MVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCVLATNEWSLIAARILQALG 114
Cdd:TIGR00898 128 KVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMG 193
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
8-154 |
4.31e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.94 E-value: 4.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 8 RQYSIGWIMLLALLTALGPLSIDMYLPALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLAL 87
Cdd:pfam07690 195 KALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLL 274
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 88 YAVASLFCVLA---TNEWSLIAARILQALGGCVGVVMARAAIRDRLDVQGSAQAFSSMMIVMGLAPILAP 154
Cdd:pfam07690 275 LILAALGLLLLsltLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
22-368 |
5.55e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 38.69 E-value: 5.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 22 TALGPLSIDMY----LPALPQMAHDFGVSTQMVANTLPAYFFGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCVL 97
Cdd:cd17478 1 LSLGHFLNDFYqgflPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 98 ATNEWSLIAARILQALGGCV----GVVMARAAIRDRldvQGSAQAFSSMMIVMGLApiLAPMIGAWILIWFPWQAIFIAL 173
Cdd:cd17478 81 APNYWLLLLLVALAGIGSAAfhpeGARLASQAAGGR---RGLAMSIFSVGGNLGFA--LGPLIAAALVALFGGLGLLILL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 174 SIVGAICWLCVHFFFKETLATDKRLKLSLYQVATLYGAIFKDASFRLPMFAGCLTGAALFCYIssapAVFMDQYGLNQQE 253
Cdd:cd17478 156 IIPGLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFL----PFYLVQRGYSLVF 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 254 FAYVFGLNAFGIMLMSSLNKHLttrveiTKRLKAGSMVQVTGASIVLIAGLISAAPLWLVMLGLFLAISGIGLTGPNAMA 333
Cdd:cd17478 232 AGLLLSLFLFAGAIGTLIGGPL------SDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVV 305
|
330 340 350
....*....|....*....|....*....|....*
gi 491023702 334 LAMSKQGARAGTASAIMGSMQFACGLLGGVLLNFL 368
Cdd:cd17478 306 LAQELLPGNVGLASGLMMGLSFGLGGIGAPVLGAL 340
|
|
| MFS_GLUT8_Class3 |
cd17433 |
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
17-163 |
6.23e-03 |
|
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340991 [Multi-domain] Cd Length: 416 Bit Score: 38.70 E-value: 6.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491023702 17 LLALLTALGPLSIDMYL----PALPQMAHDFGVSTQMvANTLPAYF-----FGLAIGQLVYGPLSDRIGRKKPLYFGLAL 87
Cdd:cd17433 2 LATFAAVLGPLSFGFVLgyssPAIPSLQRIADPALRL-DDAAASWFgsvvtLGAAAGGVLGGWIVDRAGRKLSLMLCSVP 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491023702 88 YAVASLFCVLATNEWSLIAARILQALGGCVGVVMARAAIRDRL--DVQGSAQAFSSMMIVMGlapILAPMIGAWILIW 163
Cdd:cd17433 81 FIAGFTVITAAQNVWMLYVGRLLTGLASGVTSLVVPVYISEIAhpRVRGTLGSCVQLMVVIG---IMGAYLAGLVLDW 155
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
59-114 |
9.53e-03 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 38.00 E-value: 9.53e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 491023702 59 FGLAIGQLVYGPLSDRIGRKKPLYFGLALYAVASLFCVLATNEWS-LIAARILQALG 114
Cdd:cd17356 56 LGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIIQVAAIGKWYqLIVGRIIAGLG 112
|
|
| |
