|
Name |
Accession |
Description |
Interval |
E-value |
| DinG |
COG1199 |
Rad3-related DNA helicase DinG [Replication, recombination and repair]; |
11-582 |
2.85e-53 |
|
Rad3-related DNA helicase DinG [Replication, recombination and repair];
Pssm-ID: 440812 [Multi-domain] Cd Length: 629 Bit Score: 192.83 E-value: 2.85e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 11 GLSLRKVQQDYIEAAAGALtQDHKVALISAETGVGKTLGYLVPALLILLKNPEaKFVIATNSHALMHQIFRSDrplLEQI 90
Cdd:COG1199 12 GFEPRPGQREMAEAVARAL-AEGRHLLIEAGTGTGKTLAYLVPALLAARETGK-KVVISTATKALQEQLVEKD---LPLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 91 AEQCGIKVTFSRLMGKANYVSLEKVRGLLLMDEFTDLDTVkVLEKLANWSKplvefEEEYG---ELPAQITPE---MVTY 164
Cdd:COG1199 87 RKALGLPLRVALLKGRSNYLCLRRLEQALQEGDDLDDEEL-LLARILAWAS-----ETWTGdrdELPLPEDDElwrQVTS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 165 SIWDDIQDI---------DDIRLNALSANFIVTTHAMVMVDCMCNHRILGdkENMYLIIDEA----DIFVDMLEvwkqRR 231
Cdd:COG1199 161 DADNCLGRRcpyygvcpyELARRLAREADVVVVNHHLLFADLALGEELLP--EDDVLIIDEAhnlpDRARDMFS----AE 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 232 FNLRELTSAFNE---HIPRNGVHVIDQLMNDVTSIAGDLHFC----------------STPAAVALFDNSFNALSKVGRE 292
Cdd:COG1199 235 LSSRSLLRLLRElrkLGLRPGLKKLLDLLERLREALDDLFLAleeeeelrlalgelpdEPEELLEALDALRDALEALAEA 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 293 IKNEAARKAFFD--------CIYSWE-MLGLSGGQKGVG-VSNKRREPALIAVNpfigMNVGRYCTQW-----RSALLTS 357
Cdd:COG1199 315 LEEELERLAELDallerleeLLFALArFLRIAEDEGYVRwLEREGGDVRLHAAP----LDPADLLRELlfsraRSVVLTS 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 358 ATLSItstpETGMEWLCKALGLTSDTISIRkifspdvYGS-------MKLTIagadfPKVFNDPKEQI-FSGQWLKAVVE 429
Cdd:COG1199 391 ATLSV----GGPFDYFARRLGLDEDARTLS-------LPSpfdyenqALLYV-----PRDLPRPSDRDgYLEAIAEAIAE 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 430 QLSCIQGPALVLTASHYETRMIANQL-GEVSQPVYIQKAGqALSEIIKQYQEIPGILISAGASV--GVSPRGENGEQifq 506
Cdd:COG1199 455 LLEASGGNTLVLFTSYRALEQVAELLrERLDIPVLVQGDG-SREALLERFREGGNSVLVGTGSFweGVDLPGDALSL--- 530
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 507 dLIITRIPFLPPD--RMKAesLYGYLKERG-----YSRTFEAVnrniyldnlrkviRKAKQSIGRGIRSENDTVRIIILD 579
Cdd:COG1199 531 -VIIVKLPFPPPDdpVLEA--RREALEARGgngfmYAYLPPAV-------------IKLKQGAGRLIRSEEDRGVVVLLD 594
|
...
gi 491021575 580 PRF 582
Cdd:COG1199 595 RRL 597
|
|
| PRK08074 |
PRK08074 |
bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated |
15-581 |
2.45e-22 |
|
bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated
Pssm-ID: 236148 [Multi-domain] Cd Length: 928 Bit Score: 101.95 E-value: 2.45e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 15 RKVQQDYIEAAAGALtQDHKVALISAETGVGKTLGYLVPALLILLKNpEAKFVIATNSHALMHQIFRSDRPLLEQIAeqc 94
Cdd:PRK08074 259 REGQQEMMKEVYTAL-RDSEHALIEAGTGTGKSLAYLLPAAYFAKKK-EEPVVISTYTIQLQQQLLEKDIPLLQKIF--- 333
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 95 GIKVTFSRLMGKANYVSLEKVRGLLLMDEfTDLDTVKVLEKLANWskpLVefEEEYGEL--------PAQITPEMVT--- 163
Cdd:PRK08074 334 PFPVEAALLKGRSHYLCLRKFEQALQEED-DNYDVALTKAQLLVW---LT--ETETGDLdelnlpsgGKLLWNRIASdge 407
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 164 -----YSIWDDIQDIDDIRLNALSANFIVTTHAMVMVDCMCNHRILGDKEnmYLIIDEA--------------------- 217
Cdd:PRK08074 408 sdggkQSPWFSRCFYQRAKNRAKFADLVITNHALLLTDLTSEEPLLPSYE--HIIIDEAhhfeeaasrhlgeqfsymsfq 485
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 218 ------------------------------DIFVDMLEVWKQRRFNLRELTSAFNEHI----PRNGVHVI---------- 253
Cdd:PRK08074 486 lllsrlgtleedgllsklaklfkksdqasrSSFRDLDESLKELKFEADELFQMLRSFVlkrkKQEQNGRLiyryntesek 565
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 254 DQLMNDVTSIAGDLHFcstpaavaLFDNSFNALSKVGREIKNEAARKAFFD-------------CIYSWEMLGLSGGQKG 320
Cdd:PRK08074 566 GKLWDAITELANRLCY--------DLRDLLTLLEAQKKELQEKMESESAFLtgeyahlidllekMAQLLQLLFEEDPDYV 637
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 321 V-------GVSNKRR---EPalIAVNPFIGmnvGRYCTQWRSALLTSATLSITSTpetgMEWLCKALGLTSDTISIRKIF 390
Cdd:PRK08074 638 TwieidakGAINATRlyaQP--VEVAERLA---DEFFAKKKSVILTSATLTVNGS----FDYIIERLGLEDFYPRTLQIP 708
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 391 SPDVYG-SMKLTIAgADFPKVFNDPKEQiFSGQWLKAVVEQLSCIQGPALVLTASHYETRMIANQLGEVSQPVYIQKAGQ 469
Cdd:PRK08074 709 SPFSYEeQAKLMIP-TDMPPIKDVPIEE-YIEEVAAYIAKIAKATKGRMLVLFTSYEMLKKTYYNLKNEEELEGYVLLAQ 786
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 470 ALS-----EIIKQYQEIP-GILIsaGASV---GVSPRGENgeqiFQDLIITRIPFLPPDR--MKAESlyGYLKERGYSrT 538
Cdd:PRK08074 787 GVSsgsraRLTKQFQQFDkAILL--GTSSfweGIDIPGDE----LSCLVIVRLPFAPPDQpvMEAKS--EWAKEQGEN-P 857
|
650 660 670 680
....*....|....*....|....*....|....*....|...
gi 491021575 539 FEAVnrniyldNLRKVIRKAKQSIGRGIRSENDTVRIIILDPR 581
Cdd:PRK08074 858 FQEL-------SLPQAVLRFKQGFGRLIRTETDRGTVFVLDRR 893
|
|
| dinG |
PRK11747 |
ATP-dependent DNA helicase DinG; Provisional |
26-581 |
5.03e-21 |
|
ATP-dependent DNA helicase DinG; Provisional
Pssm-ID: 236966 [Multi-domain] Cd Length: 697 Bit Score: 97.59 E-value: 5.03e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 26 AGALTQDHKVALISAETGVGKTLGYLVPALLILLKNpEAKFVIATNSHALMHQIFRSDRPLLeqiAEQCGIKVTFSRLMG 105
Cdd:PRK11747 42 AGEYLKDGRILVIEAGTGVGKTLSYLLAGIPIARAE-KKKLVISTATVALQEQLVSKDLPLL---LKISGLDFKFTLAKG 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 106 KANYVSLEKVRGLL--------LMDEFTDLDT------VKVLEKLA-------------NWSKPLvefEEE--------- 149
Cdd:PRK11747 118 RGRYVCPRKLAALAsdegtqqdLLLFLDDELTppdeeeQKLLARLAkalatgkwdgdrdHWPEPI---DDSlwqrittdk 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 150 ----------YGELPAQITPEMVTysiwddiqdiddirlnalSANFIVTTHAMVMVDC-MCNHRILGDKENMYLIIDEA- 217
Cdd:PRK11747 195 hsclgrncpyFRECPFFKARREID------------------EADVVVANHDLVLADLeLGGGVVLPDPENLLYVLDEGh 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 218 ---DIFVDMLEV---WKQRRFNLRELTSAF---NEHIPRNGVHVIDQLMNDVTSIAGDLHFCSTpaAVALFDNSFN---- 284
Cdd:PRK11747 257 hlpDVARDHFAAsaeLKGTADWLEKLLKLLtklVALIMEPPLALPERLNAHCEELRELLASLNQ--ILNLFLPAGGeear 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 285 ----------ALSKVGREIKN--EAARKAFfdciyswEMLG--LSGGQKGVGVSNKRREPALIAVNPFIGM--------- 341
Cdd:PRK11747 335 yrfemgelpeELLELAERLAKltEKLLGLL-------EKLLndLSEAMKTGKIDIVRLERLLLELGRALGRlealsklwr 407
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 342 -----------------------------------NVGRYCTQ--WRS---ALLTSATL-SITStpetgMEWLCKALGLT 380
Cdd:PRK11747 408 laakedqesgapmarwitreerdgqgdylfhaspiRVGDQLERllWSRapgAVLTSATLrSLNS-----FDRFQEQSGLP 482
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 381 SD----TISIRkifSPDVYGSM-KLTIagadfPKVFNDPKEqifSGQWLKAVVEQLSCI----QGpALVLTASHYETRMI 451
Cdd:PRK11747 483 EKdgdrFLALP---SPFDYPNQgKLVI-----PKMRAEPDN---EEAHTAEMAEFLPELlekhKG-SLVLFASRRQMQKV 550
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 452 ANQL-GEVSQPVYIQkaG-QALSEIIKQYQEipgiLISAG-ASV---------GVSPRGENGEQifqdLIITRIPFLPPD 519
Cdd:PRK11747 551 ADLLpRDLRLMLLVQ--GdQPRQRLLEKHKK----RVDEGeGSVlfglqsfaeGLDLPGDYLTQ----VIITKIPFAVPD 620
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 491021575 520 RMKAESLYGYLKERGysrtfeavnRNIYL-----DNLRKVIrkakQSIGRGIRSENDTVRIIILDPR 581
Cdd:PRK11747 621 SPVEATLAEWLKSRG---------GNPFMeisvpDASFKLI----QAVGRLIRSEQDRGRVTILDRR 674
|
|
| Helicase_C_2 |
pfam13307 |
Helicase C-terminal domain; This domain is found at the C-terminus of DEAD-box helicases. |
428-585 |
5.02e-17 |
|
Helicase C-terminal domain; This domain is found at the C-terminus of DEAD-box helicases.
Pssm-ID: 463840 [Multi-domain] Cd Length: 168 Bit Score: 78.76 E-value: 5.02e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 428 VEQLSCIQGPALVLTASHYETRMIANQL----GEVSQPVYIQKAGQALSEIIKQYQEI--PGILIS-AGASV--GVSPRG 498
Cdd:pfam13307 1 LRLLKVIPGGVLVFFPSYSYLEKVAERLkesgLEKGIEIFVQPGEGSREKLLEEFKKKgkGAVLFGvCGGSFseGIDFPG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 499 ENGEQifqdLIITRIPFLPPDRMKAESLYGYLKERGySRTFEAVNrniyldnLRKVIRKAKQSIGRGIRSENDTVRIIIL 578
Cdd:pfam13307 81 DLLRA----VIIVGLPFPNPDDPVVEAKREYLDSKG-GNPFNEWY-------LPQAVRAVNQAIGRLIRHENDYGAIVLL 148
|
....*..
gi 491021575 579 DPRFPEP 585
Cdd:pfam13307 149 DSRFLTK 155
|
|
| HELICc2 |
smart00491 |
helicase superfamily c-terminal domain; |
449-582 |
1.28e-12 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 214694 [Multi-domain] Cd Length: 142 Bit Score: 65.38 E-value: 1.28e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 449 RMIANQLGEVSQPVYIQ-KAGQALSEIIKQYQEIpgilISAGASVGVS-PRGENGEQI-FQD-----LIITRIPFLPPD- 519
Cdd:smart00491 10 YWKENGILEINKPVFIEgKDSGETEELLEKYSAA----CEARGALLLAvARGKVSEGIdFPDdlgraVIIVGIPFPNPDs 85
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491021575 520 -RMKAESLYgyLKERGYSRTFEAVNRNiyldnlrKVIRKAKQSIGRGIRSENDTVRIIILDPRF 582
Cdd:smart00491 86 pILRARLEY--LDEKGGIRPFDEVYLF-------DAMRALAQAIGRAIRHKNDYGVVVLLDKRY 140
|
|
| Csf4_U |
cd09708 |
CRISPR/Cas system-associated DinG family helicase Csf4; CRISPR (Clustered Regularly ... |
34-581 |
2.44e-11 |
|
CRISPR/Cas system-associated DinG family helicase Csf4; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DinG family DNA helicase
Pssm-ID: 187839 [Multi-domain] Cd Length: 632 Bit Score: 66.54 E-value: 2.44e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 34 KVALISAETGVGKTLGYLVPALLILLKNPEAKFVIATNSHALMHQIFRSDRPLleqIAEQCGIKVTFSRLMGKANYVSLE 113
Cdd:cd09708 17 RIGMLEASTGVGKTLAMIMAALTMLKERPDQKIAIAVPTLALMGQLWSELERL---TAEGLAGPVQAGFFPGSQEFVSPG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 114 KVRGLL-LMDEFTDLDTVKVLEKLANWSKPLVEF----------------EEEYGELPAQI-TPEMVTYSIWD-DIQDID 174
Cdd:cd09708 94 ALQELLdQSDGPGDKDAVVRLWMGQGGPRKVAPLfnrmrdvtllihdtadIRGYVSYREQWdSLPRCSAMSRApTKMASM 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 175 DIRLNALSAN-------------------------FIVTTHAMVMVDCMCNHRILGDKEnmYLIIDEADIFVDMLEVWKQ 229
Cdd:cd09708 174 THDLKALATLnpqdfvtedeedkrwvtslvesreyYARKSRILACTHTMLKWGLLPQPD--ILIVDEAHLFEQNISRVYS 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 230 RRFNLREL---------------------TSAFNEHIPRNGVHVIDQLM--NDVTSIAGDLhFCSTPAAVALFDNSFNAL 286
Cdd:cd09708 252 NALSLRMLrfhlevshrktgaigsavvaaVSAVSHRLRQVSALGDGQTLclDAGNKELETL-FADLDAALEIKSTPNKKA 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 287 SKVGREIkneaaRKAFFdcIYSWEMLGLSGGQKGVGV--SNKRREPALIavnpfigmnVGRYCTQ------W----RSAL 354
Cdd:cd09708 331 LSVVKDV-----KKARI--ILDNAITAIQGKQSTVYLqfSPDRRFPSLI---------VGREDLGkvmgglWkdvtHGAI 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 355 LTSATLSItstPETGMEWLC----KALGLTSDTI-SIRKIFSPDVYG---SMKLTIAGADFPKVFNDPKEQIFS---GQW 423
Cdd:cd09708 395 IVSATLYL---PDRFGQMSCdylkRVLSLPLSRLdTPSPIVAPWVRNlipHLHVPNAKARFLLSRPVGKTEQGDanlAGW 471
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 424 LKAVVEQLSCI----QGPALVLTASHYETRMIAnQLGE--VSQPVYIQKAGQALSEIIKQYQE-----IPGILISAGA-- 490
Cdd:cd09708 472 LENVSLSTAAIlrkaQGGTLVLTTAFSHISAIG-QLVElgIPAEIVIQSEKNRLASAEQQFLAlyangIQPVLIAAGGaw 550
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 491 ------SVGVSPRGENgeqIFQDLIITRIPFlppdrmkaeslyGYlkERGYSRTFEAVNRNIYLDNLRKVIRKAKQSIGR 564
Cdd:cd09708 551 tgidlhDPSVSPDKDN---LLTDLIITCAPF------------GL--NRSLSMLKRIRKTSVRPEIINESLMMLRQGLGR 613
|
650
....*....|....*....
gi 491021575 565 GIRSEN--DTVRIIILDPR 581
Cdd:cd09708 614 LVRHPDmpINRRIHDLDPR 632
|
|
| PRK07246 |
PRK07246 |
bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated |
11-581 |
3.64e-09 |
|
bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated
Pssm-ID: 180905 [Multi-domain] Cd Length: 820 Bit Score: 59.70 E-value: 3.64e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 11 GLSLRKVQQDYIEAAaGALTQDHKVALISAETGVGKTLGYLVPAlliLLKNPEAKFVIATNSHALMHQIFRSDrplLEQI 90
Cdd:PRK07246 243 GLEERPKQESFAKLV-GEDFHDGPASFIEAQTGIGKTYGYLLPL---LAQSDQRQIIVSVPTKILQDQIMAEE---VKAI 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 91 AEQCGIkvTFSRLMGKANYVSLE------------------KVRGL--LLMDEFTDLDTVKVLEKLANWskplveFEE-- 148
Cdd:PRK07246 316 QEVFHI--DCHSLKGPQNYLKLDafydslqqnddnrlvnryKMQLLvwLTETETGDLDEIKQKQRYAAY------FDQlk 387
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 149 EYGELPAQitPEMVTYSIWDDIQDiddirlNALSANFIVTTHAMVMvdcmcnHRILGDKE---NMYLIIDEADIFVDMLE 225
Cdd:PRK07246 388 HDGNLSQS--SLFYDYDFWKRSYE------KAKTARLLITNHAYFL------TRVQDDKDfarNKVLVFDEAQKLMLQLE 453
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 226 VWKQRRFNLRELTSAFNEHI----PRNGVHVIDQLMNDVTSIAGDLH----FCSTPAAVALFDNSFNALSKVG----REI 293
Cdd:PRK07246 454 QLSRHQLNITSFLQTIQKALsgplPLLQKRLLESISFELLQLSEQFYqgkeRQLIHDSLSRLHQYFSELEVAGfqelQAF 533
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 294 KNEAARKAFFDCIYSWEmlglsggqKGVGVSNKRREPALiavnpfigmNVGRYCTQWRSALLTSATLSItsTPETGmewL 373
Cdd:PRK07246 534 FATAEGDYWLESEKQSE--------KRVTYLNSASKAFT---------HFSQLLPETCKTYFVSATLQI--SPRVS---L 591
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 374 CKALGLTS---DTISIRKifspdvyGSMKLTIAGADFPKVfNDPKEQIFsGQWLKAVVEQLSCIQGPALVLTASHYETRM 450
Cdd:PRK07246 592 ADLLGFEEylfHKIEKDK-------KQDQLVVVDQDMPLV-TETSDEVY-AEEIAKRLEELKQLQQPILVLFNSKKHLLA 662
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 451 IANQLGEVSQPVYIQ-KAGQALSeIIKQYQEipG---ILISAGASvgvsprGENGEQIFQDL---IITRIPFLPPDRMKA 523
Cdd:PRK07246 663 VSDLLDQWQVSHLAQeKNGTAYN-IKKRFDR--GeqqILLGLGSF------WEGVDFVQADRmieVITRLPFDNPEDPFV 733
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*....
gi 491021575 524 ESLYGYLKERGysrtfeavnRNIYLD-NLRKVIRKAKQSIGRGIRSENDTVRIIILDPR 581
Cdd:PRK07246 734 KKMNQYLLQEG---------KNPFYDyFLPMTILRLKQAIGRTMRREDQKSAVLILDRR 783
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
6-160 |
1.89e-07 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 51.72 E-value: 1.89e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 6 VFESAGLSLRKVQQDYIEAaagaLTQDHKVALISAETGVGKTLGYLVPALLILLKNPEAKFVIATNSHALMHQIFR---- 81
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEA----LLSGLRDVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPTRELAEQWAEelkk 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 82 ----------------SDRPLLEQIAEQC-GIKV-TFSRL--MGKANYVSLEKVRgLLLMDE---FTDLDTVKVLEKL-- 136
Cdd:smart00487 77 lgpslglkvvglyggdSKREQLRKLESGKtDILVtTPGRLldLLENDKLSLSNVD-LVILDEahrLLDGGFGDQLEKLlk 155
|
170 180 190
....*....|....*....|....*....|....*.
gi 491021575 137 ------------ANWSKPLVEFEEEYGELPAQITPE 160
Cdd:smart00487 156 llpknvqllllsATPPEEIENLLELFLNDPVFIDVG 191
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
12-124 |
1.72e-05 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 47.71 E-value: 1.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 12 LSLRKVQQDYIEAAAGALTQDHKVALISAETGVGKTlgyLVPALLILLKNPEAKFVIATNSHALMHQIFRSDRPLLEQIA 91
Cdd:COG1061 79 FELRPYQQEALEALLAALERGGGRGLVVAPTGTGKT---VLALALAAELLRGKRVLVLVPRRELLEQWAEELRRFLGDPL 155
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 491021575 92 EQCGIK--------VTFSRLMGKANYVSLEKVRGLLLMDEF 124
Cdd:COG1061 156 AGGGKKdsdapitvATYQSLARRAHLDELGDRFGLVIIDEA 196
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
15-223 |
1.88e-05 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 45.31 E-value: 1.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 15 RKVQQDYIEAaagaLTQDHKVaLISAETGVGKTLGYLVPALLILLKNPEAK--FVIATnSHALMHQIFRSdrplLEQIAE 92
Cdd:pfam00270 1 TPIQAEAIPA----ILEGRDV-LVQAPTGSGKTLAFLLPALEALDKLDNGPqaLVLAP-TRELAEQIYEE----LKKLGK 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 93 QCGIKVTFsrlmgkanyvslekvrglllmdEFTDLDTVKVLEKLANwskplvefeeeygelpaqitpemvtysiwddiqd 172
Cdd:pfam00270 71 GLGLKVAS----------------------LLGGDSRKEQLEKLKG---------------------------------- 94
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 491021575 173 iddirlnalsANFIVTTHAMVMvDCMCNHRILGDKEnmYLIIDEADIFVDM 223
Cdd:pfam00270 95 ----------PDILVGTPGRLL-DLLQERKLLKNLK--LLVLDEAHRLLDM 132
|
|
| SF2_C_XPD |
cd18788 |
C-terminal helicase domain of xeroderma pigmentosum group D (XPD) family DEAD-like helicases; ... |
436-582 |
4.75e-05 |
|
C-terminal helicase domain of xeroderma pigmentosum group D (XPD) family DEAD-like helicases; The xeroderma pigmentosum group D (XPD)-like family members are DEAD-box helicases belonging to superfamily (SF)2. This family includes DDX11 (also called ChlR1), a protein involved in maintaining chromosome transmission fidelity and genome stability, the TFIIH basal transcription factor complex XPD subunit, and FANCJ (also known as BRIP1), a DNA helicase required for the maintenance of chromosomal stability. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350175 [Multi-domain] Cd Length: 159 Bit Score: 44.13 E-value: 4.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 436 GPALVLTASHYETRMianqlgevsQPVYIQKAGQALSEIIKQyqeIP-GIL------------ISAGA---SVGvspRGE 499
Cdd:cd18788 11 GPDQQALNSKFQTRE---------DEAVMDELGNLLLELCAV---VPdGVLvffpsysymervVSRGAlllAVC---RGK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 500 NGEQI-FQD-----LIITRIPFLPPD----RMKAESLyGYLKERGYSR-----TFEAvnrniyldnlrkvIRKAKQSIGR 564
Cdd:cd18788 76 VSEGIdFSDdlgraVIMVGIPYPNTKdpilKLKMDDL-EYLRDKGLLTgedwyTFQA-------------MRAVNQAIGR 141
|
170
....*....|....*...
gi 491021575 565 GIRSENDTVRIIILDPRF 582
Cdd:cd18788 142 AIRHKNDYGAIVLLDKRF 159
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
33-87 |
2.81e-04 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 41.62 E-value: 2.81e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 491021575 33 HKVALISAETGVGKTLGYLVPALLILLKnPEAKFVIATNSHALMHQIFRSDRPLL 87
Cdd:cd00046 1 GENVLITAPTGSGKTLAALLAALLLLLK-KGKKVLVLVPTKALALQTAERLRELF 54
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
24-105 |
5.50e-04 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 41.42 E-value: 5.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 24 AAAGALTQDHKVALISAETGVGKTLGYLVPALLILLKNPEAK--FVIATNshALMHQIFRSdrplLEQIAEQCGIKVTFS 101
Cdd:cd17923 6 AEAIEAARAGRSVVVTTGTASGKSLCYQLPILEALLRDPGSRalYLYPTK--ALAQDQLRS----LRELLEQLGLGIRVA 79
|
....
gi 491021575 102 RLMG 105
Cdd:cd17923 80 TYDG 83
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
37-109 |
6.51e-04 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 41.27 E-value: 6.51e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491021575 37 LISAETGVGKTLGYLVPALLILLKNPEAKF-----VIATNSHALMHQIFRSdrplLEQIAEQCGIKVTfsRLMGKANY 109
Cdd:cd00268 31 IGQAQTGSGKTLAFLLPILEKLLPEPKKKGrgpqaLVLAPTRELAMQIAEV----ARKLGKGTGLKVA--AIYGGAPI 102
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
37-98 |
1.85e-03 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 40.43 E-value: 1.85e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 37 LISAETGVGKTLGYLVPALLILLKNPEAKF--------VIATNSHALMHQIfrsdRPLLEQIAEQCGIKV 98
Cdd:cd17948 31 LCAAETGSGKTLTYLLPIIQRLLRYKLLAEgpfnaprgLVITPSRELAEQI----GSVAQSLTEGLGLKV 96
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
13-94 |
2.47e-03 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 39.87 E-value: 2.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 13 SLRKVQQDYIEAAagaLTQDHKVaLISAETGVGKTLGYLVPALLILLKNPEAkfviATNS--HALmhqIFRSDRPLLEQI 90
Cdd:cd17964 16 TMTPVQQKTLKPI---LSTGDDV-LARAKTGTGKTLAFLLPAIQSLLNTKPA----GRRSgvSAL---IISPTRELALQI 84
|
....
gi 491021575 91 AEQC 94
Cdd:cd17964 85 AAEA 88
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
23-65 |
3.21e-03 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 40.59 E-value: 3.21e-03
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 491021575 23 EAAAGALTQDHKValISAETGVGKTLGYLVPALLILLKNPEAK 65
Cdd:COG1205 63 EAIEAARAGKNVV--IATPTASGKSLAYLLPVLEALLEDPGAT 103
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
16-94 |
3.89e-03 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 39.93 E-value: 3.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 16 KVQQDYIEAAagaltQDHKVALISAETGVGKTLGYLVPALLILLKNPE-----AKFVIATNShalmhqifrsdRPLLEQI 90
Cdd:PRK11192 26 AIQAEAIPPA-----LDGRDVLGSAPTGTGKTAAFLLPALQHLLDFPRrksgpPRILILTPT-----------RELAMQV 89
|
....
gi 491021575 91 AEQC 94
Cdd:PRK11192 90 ADQA 93
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
32-62 |
5.85e-03 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 38.72 E-value: 5.85e-03
10 20 30
....*....|....*....|....*....|.
gi 491021575 32 DHKVALISAETGVGKTLGYLVPALLILLKNP 62
Cdd:cd17949 27 QGRDVLVRSQTGSGKTLAYLLPIIQRLLSLE 57
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
34-65 |
7.51e-03 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 38.51 E-value: 7.51e-03
10 20 30
....*....|....*....|....*....|..
gi 491021575 34 KVALISAETGVGKTLGYLVPaLLILLKNPEAK 65
Cdd:cd17965 62 EVFLLAAETGSGKTLAYLAP-LLDYLKRQEQE 92
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
37-108 |
9.01e-03 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 37.73 E-value: 9.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491021575 37 LISAETGVGKTLGYLVPALLILLKNpeaKF--------VIATNSHALMHQIFRSDRPLLEQIAEQCGIkvtfsrLMGKAN 108
Cdd:cd17942 31 LGAAKTGSGKTLAFLIPAIELLYKL---KFkprngtgvIIISPTRELALQIYGVAKELLKYHSQTFGI------VIGGAN 101
|
|
| |
