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Conserved domains on  [gi|491004467|ref|WP_004866188|]
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MULTISPECIES: arsenate reductase (glutaredoxin) [Raoultella]

Protein Classification

arsenate reductase family protein( domain architecture ID 10122547)

arsenate reductase (ArsC) family protein similar to Synechocystis sp. arsenate reductases ArsI1 and ArsI2, which are glutaredoxin-dependent enzymes that catalyze the reduction of arsenate [As(V)] to arsenite [As(III)]

PubMed:  15558583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsC_ArsC cd03034
Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded ...
 5-117 1.11e-57

Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the detoxification of arsenic, using reducing equivalents derived from glutathione (GSH) via glutaredoxin (GRX). ArsC contains a single catalytic cysteine, within a thioredoxin fold, that forms a covalent thiolate-As(V) intermediate, which is reduced by GRX through a mixed GSH-arsenate intermediate. This family of predominantly bacterial enzymes is unrelated to two other families of arsenate reductases which show similarity to low-molecular-weight acid phosphatases and phosphotyrosyl phosphatases.


:

Pssm-ID: 239332  Cd Length: 112  Bit Score: 173.54  E-value: 1.11e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491004467   5 VKIYHNPRCSKSRDTLSLLKANGIDPEVVLYLETPPDADTLRQLLKMLGMvSARELMRQKEDLYKSLELADPQLSEEALI 84
Cdd:cd03034    1 ITIYHNPRCSKSRNALALLEEAGIEPEIVEYLKTPPTAAELRELLAKLGI-SPRDLLRTKEAPYKELGLADPELSDEELI 79

                         90       100       110
                 ....*....|....*....|....*....|...
gi 491004467  85 QAIVDNPKLMERPIVVSHGQARIGRPPEQVLEI 117
Cdd:cd03034   80 DAMAAHPILIERPIVVTGDGAVLGRPPEAVLEL 112
 
Name Accession Description Interval E-value
ArsC_ArsC cd03034
Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded ...
 5-117 1.11e-57

Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the detoxification of arsenic, using reducing equivalents derived from glutathione (GSH) via glutaredoxin (GRX). ArsC contains a single catalytic cysteine, within a thioredoxin fold, that forms a covalent thiolate-As(V) intermediate, which is reduced by GRX through a mixed GSH-arsenate intermediate. This family of predominantly bacterial enzymes is unrelated to two other families of arsenate reductases which show similarity to low-molecular-weight acid phosphatases and phosphotyrosyl phosphatases.


Pssm-ID: 239332  Cd Length: 112  Bit Score: 173.54  E-value: 1.11e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491004467   5 VKIYHNPRCSKSRDTLSLLKANGIDPEVVLYLETPPDADTLRQLLKMLGMvSARELMRQKEDLYKSLELADPQLSEEALI 84
Cdd:cd03034    1 ITIYHNPRCSKSRNALALLEEAGIEPEIVEYLKTPPTAAELRELLAKLGI-SPRDLLRTKEAPYKELGLADPELSDEELI 79

                         90       100       110
                 ....*....|....*....|....*....|...
gi 491004467  85 QAIVDNPKLMERPIVVSHGQARIGRPPEQVLEI 117
Cdd:cd03034   80 DAMAAHPILIERPIVVTGDGAVLGRPPEAVLEL 112
arsC TIGR00014
arsenate reductase (glutaredoxin); This model describes a distinct clade, including ArsC ...
 5-118 1.84e-52

arsenate reductase (glutaredoxin); This model describes a distinct clade, including ArsC itself, of the broader ArsC family described by Pfam pfam03960. This clade is almost completely restricted to the Proteobacteria. An anion-translocating ATPase has been identified as the product of the arsenical resistance operon of resistance plasmid R773. When expressed in Escherichia coli this ATP-driven oxyanion pump catalyses extrusion of the oxyanions arsenite, antimonite and arsenate. The pump is composed of two polypeptides, the products of the arsA and arsB genes. The pump alone produces resistance to arsenite and antimonite. This protein, ArsC, catalyzes the reduction of arsenate to arsenite, and thus extends resistance to include arsenate. [Cellular processes, Detoxification]


Pssm-ID: 272855  Cd Length: 114  Bit Score: 160.70  E-value: 1.84e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491004467    5 VKIYHNPRCSKSRDTLSLLKANGIDPEVVLYLETPPDADTLRQLLKMLGMVSARELMRQKEDLYKSLELADPQLSEEALI 84
Cdd:TIGR00014   1 VTIYHNPRCSKSRNTLALLEDKGIEPEVVKYLKNPPTKSELEAIFAKLGLTVAREMIRTKEALYKELGLSDPNLSDQELL 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 491004467   85 QAIVDNPKLMERPIVVSHGQARIGRPPEQVLEIV 118
Cdd:TIGR00014  81 DAMVAHPILLERPIVVAGDGARIGRPPENVLDIL 114
ArsC COG1393
Arsenate reductase or related protein, glutaredoxin family [Inorganic ion transport and ...
 5-117 4.84e-49

Arsenate reductase or related protein, glutaredoxin family [Inorganic ion transport and metabolism];


Pssm-ID: 441003  Cd Length: 115  Bit Score: 151.78  E-value: 4.84e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491004467   5 VKIYHNPRCSKSRDTLSLLKANGIDPEVVLYLETPPDADTLRQLLKMLGMvSARELMRQKEDLYKSLELADPQLSEEALI 84
Cdd:COG1393    2 ITIYGNPNCSTSRKALAWLEEAGIEYEFIDYLKTPPTAEELKELLAKLGL-GVEELLNTRGTTYRELGLKDKALSEEEAL 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 491004467  85 QAIVDNPKLMERPIVVSHGQARIGRPPEQVLEI 117
Cdd:COG1393   81 ALMLEHPSLIKRPIVVTGDKALVGFPPEEVLAL 113
ArsC pfam03960
ArsC family; This family is related to glutaredoxins pfam00462.
 8-117 3.57e-42

ArsC family; This family is related to glutaredoxins pfam00462.


Pssm-ID: 427617  Cd Length: 109  Bit Score: 134.26  E-value: 3.57e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491004467    8 YHNPRCSKSRDTLSLLKANGIDPEVVLYLETPPDADTLRQLLKMLGMvSARELMRQKEDLYKSLELADPQLSEEALIQAI 87
Cdd:pfam03960   1 YGSPNCSTCRKALAWLEEHGIEYQEIDYLETPPSKEELKDILAKLGD-GVEALLNTRGTTYRELNLDKEDLSEDELLELI 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 491004467   88 VDNPKLMERPIVVSHGQARIGRPPEQVLEI 117
Cdd:pfam03960  80 LEHPSLIRRPIVVDGGKLLVGFNEEEIRAF 109
PRK10026 PRK10026
arsenate reductase (glutaredoxin);
1-118 3.95e-27

arsenate reductase (glutaredoxin);


Pssm-ID: 182200  Cd Length: 141  Bit Score: 97.20  E-value: 3.95e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491004467   1 MSDaVKIYHNPRCSKSRDTLSLLKANGIDPEVVLYLETPPDADTLRQLLKMLGMvSARELMRQKEDLYKSLELADPQLSE 80
Cdd:PRK10026   1 MSN-ITIYHNPACGTSRNTLEMIRNSGTEPTIIHYLETPPTRDELVKLIADMGI-SVRALLRKNVEPYEELGLAEDKFTD 78

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 491004467  81 EALIQAIVDNPKLMERPIVVSHGQARIGRPPEQVLEIV 118
Cdd:PRK10026  79 DQLIDFMLQHPILINRPIVVTPLGTRLCRPSEVVLEIL 116
 
Name Accession Description Interval E-value
ArsC_ArsC cd03034
Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded ...
 5-117 1.11e-57

Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the detoxification of arsenic, using reducing equivalents derived from glutathione (GSH) via glutaredoxin (GRX). ArsC contains a single catalytic cysteine, within a thioredoxin fold, that forms a covalent thiolate-As(V) intermediate, which is reduced by GRX through a mixed GSH-arsenate intermediate. This family of predominantly bacterial enzymes is unrelated to two other families of arsenate reductases which show similarity to low-molecular-weight acid phosphatases and phosphotyrosyl phosphatases.


Pssm-ID: 239332  Cd Length: 112  Bit Score: 173.54  E-value: 1.11e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491004467   5 VKIYHNPRCSKSRDTLSLLKANGIDPEVVLYLETPPDADTLRQLLKMLGMvSARELMRQKEDLYKSLELADPQLSEEALI 84
Cdd:cd03034    1 ITIYHNPRCSKSRNALALLEEAGIEPEIVEYLKTPPTAAELRELLAKLGI-SPRDLLRTKEAPYKELGLADPELSDEELI 79

                         90       100       110
                 ....*....|....*....|....*....|...
gi 491004467  85 QAIVDNPKLMERPIVVSHGQARIGRPPEQVLEI 117
Cdd:cd03034   80 DAMAAHPILIERPIVVTGDGAVLGRPPEAVLEL 112
arsC TIGR00014
arsenate reductase (glutaredoxin); This model describes a distinct clade, including ArsC ...
 5-118 1.84e-52

arsenate reductase (glutaredoxin); This model describes a distinct clade, including ArsC itself, of the broader ArsC family described by Pfam pfam03960. This clade is almost completely restricted to the Proteobacteria. An anion-translocating ATPase has been identified as the product of the arsenical resistance operon of resistance plasmid R773. When expressed in Escherichia coli this ATP-driven oxyanion pump catalyses extrusion of the oxyanions arsenite, antimonite and arsenate. The pump is composed of two polypeptides, the products of the arsA and arsB genes. The pump alone produces resistance to arsenite and antimonite. This protein, ArsC, catalyzes the reduction of arsenate to arsenite, and thus extends resistance to include arsenate. [Cellular processes, Detoxification]


Pssm-ID: 272855  Cd Length: 114  Bit Score: 160.70  E-value: 1.84e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491004467    5 VKIYHNPRCSKSRDTLSLLKANGIDPEVVLYLETPPDADTLRQLLKMLGMVSARELMRQKEDLYKSLELADPQLSEEALI 84
Cdd:TIGR00014   1 VTIYHNPRCSKSRNTLALLEDKGIEPEVVKYLKNPPTKSELEAIFAKLGLTVAREMIRTKEALYKELGLSDPNLSDQELL 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 491004467   85 QAIVDNPKLMERPIVVSHGQARIGRPPEQVLEIV 118
Cdd:TIGR00014  81 DAMVAHPILLERPIVVAGDGARIGRPPENVLDIL 114
ArsC COG1393
Arsenate reductase or related protein, glutaredoxin family [Inorganic ion transport and ...
 5-117 4.84e-49

Arsenate reductase or related protein, glutaredoxin family [Inorganic ion transport and metabolism];


Pssm-ID: 441003  Cd Length: 115  Bit Score: 151.78  E-value: 4.84e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491004467   5 VKIYHNPRCSKSRDTLSLLKANGIDPEVVLYLETPPDADTLRQLLKMLGMvSARELMRQKEDLYKSLELADPQLSEEALI 84
Cdd:COG1393    2 ITIYGNPNCSTSRKALAWLEEAGIEYEFIDYLKTPPTAEELKELLAKLGL-GVEELLNTRGTTYRELGLKDKALSEEEAL 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 491004467  85 QAIVDNPKLMERPIVVSHGQARIGRPPEQVLEI 117
Cdd:COG1393   81 ALMLEHPSLIKRPIVVTGDKALVGFPPEEVLAL 113
ArsC pfam03960
ArsC family; This family is related to glutaredoxins pfam00462.
 8-117 3.57e-42

ArsC family; This family is related to glutaredoxins pfam00462.


Pssm-ID: 427617  Cd Length: 109  Bit Score: 134.26  E-value: 3.57e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491004467    8 YHNPRCSKSRDTLSLLKANGIDPEVVLYLETPPDADTLRQLLKMLGMvSARELMRQKEDLYKSLELADPQLSEEALIQAI 87
Cdd:pfam03960   1 YGSPNCSTCRKALAWLEEHGIEYQEIDYLETPPSKEELKDILAKLGD-GVEALLNTRGTTYRELNLDKEDLSEDELLELI 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 491004467   88 VDNPKLMERPIVVSHGQARIGRPPEQVLEI 117
Cdd:pfam03960  80 LEHPSLIRRPIVVDGGKLLVGFNEEEIRAF 109
ArsC_family cd02977
Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins ...
 5-109 6.31e-39

Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from glutathione (GSH) via glutaredoxin (GRX), through a single catalytic cysteine. This family of predominantly bacterial enzymes is unrelated to two other families of arsenate reductases which show similarity to low-molecular-weight acid phosphatases and phosphotyrosyl phosphatases. Spx is a general regulator that exerts negative and positive control over transcription initiation by binding to the C-terminal domain of the alpha subunit of RNA polymerase.


Pssm-ID: 239275  Cd Length: 105  Bit Score: 126.07  E-value: 6.31e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491004467   5 VKIYHNPRCSKSRDTLSLLKANGIDPEVVLYLETPPDADTLRQLLKMLGMvSARELMRQKEDLYKSLELADPQ-LSEEAL 83
Cdd:cd02977    1 ITIYGNPNCSTSRKALAWLEEHGIEYEFIDYLKEPPTKEELKELLAKLGL-GVEDLFNTRGTPYRKLGLADKDeLSDEEA 79

                         90       100
                 ....*....|....*....|....*.
gi 491004467  84 IQAIVDNPKLMERPIVVSHGQARIGR 109
Cdd:cd02977   80 LELMAEHPKLIKRPIVVDGDRLLVGF 105
PRK10026 PRK10026
arsenate reductase (glutaredoxin);
1-118 3.95e-27

arsenate reductase (glutaredoxin);


Pssm-ID: 182200  Cd Length: 141  Bit Score: 97.20  E-value: 3.95e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491004467   1 MSDaVKIYHNPRCSKSRDTLSLLKANGIDPEVVLYLETPPDADTLRQLLKMLGMvSARELMRQKEDLYKSLELADPQLSE 80
Cdd:PRK10026   1 MSN-ITIYHNPACGTSRNTLEMIRNSGTEPTIIHYLETPPTRDELVKLIADMGI-SVRALLRKNVEPYEELGLAEDKFTD 78

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 491004467  81 EALIQAIVDNPKLMERPIVVSHGQARIGRPPEQVLEIV 118
Cdd:PRK10026  79 DQLIDFMLQHPILINRPIVVTPLGTRLCRPSEVVLEIL 116
ArsC_like cd03036
Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a ...
 5-108 1.45e-12

Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX) function as protein disulfide oxidoreductases, altering the redox state of target proteins via the reversible oxidation of the active site dithiol. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from glutathione via GRX, through a single catalytic cysteine.


Pssm-ID: 239334  Cd Length: 111  Bit Score: 59.18  E-value: 1.45e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491004467   5 VKIYHNPRCSKSRDTLSLLKANGIDPEVVLYLETPPDADTLRQLLKMLGmVSARELMRQKEDLYKSLELAD--PQLSEEA 82
Cdd:cd03036    1 LKFYEYPKCSTCRKAKKWLDEHGVDYTAIDIVEEPPSKEELKKWLEKSG-LPLKKFFNTSGKSYRELGLKDklPSLSEEE 79

                         90       100
                 ....*....|....*....|....*.
gi 491004467  83 LIQAIVDNPKLMERPIVVSHGQARIG 108
Cdd:cd03036   80 ALELLSSDGMLIKRPFVVDDDKVLVG 105
ArsC_Spx cd03032
Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding ...
 5-108 3.01e-10

Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex formation between RNAP and certain transcriptional activator proteins like ResD and ComA. In response to oxidative stress, Spx can also activate transcription, making it a general regulator that exerts both positive and negative control over transcription initiation. Spx has been shown to exert redox-sensitive transcriptional control over genes like trxA (TRX) and trxB (TRX reductase), genes that function in thiol homeostasis. This redox-sensitive activity is dependent on the presence of a CXXC motif, present in some members of the Spx subfamily, that acts as a thiol/disulfide switch. Spx has also been shown to repress genes in a sulfate-dependent manner independent of the presence of the CXXC motif.


Pssm-ID: 239330  Cd Length: 115  Bit Score: 53.40  E-value: 3.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491004467   5 VKIYHNPRCSKSRDTLSLLKANGIDPEVVLYLETPPDADTLRQLLKmLGMVSARELMRQKEDLYKSLELADPQLSEEALI 84
Cdd:cd03032    2 IKLYTSPSCSSCRKAKQWLEEHQIPFEERNLFKQPLTKEELKEILS-LTENGVEDIISTRSKAFKNLNIDIDELSLSELI 80

                         90       100
                 ....*....|....*....|....
gi 491004467  85 QAIVDNPKLMERPIVVSHGQARIG 108
Cdd:cd03032   81 RLISEHPSLLRRPIIIDEKRLQIG 104
arsC_related TIGR01617
transcriptional regulator, Spx/MgsR family; This model represents a portion of the proteins ...
 5-116 1.42e-07

transcriptional regulator, Spx/MgsR family; This model represents a portion of the proteins within the larger set covered by pfam03960. That larger family includes a glutaredoxin-dependent arsenate reductase (TIGR00014). Characterized members of this family include Spx and MgsR from Bacillus subtili. Spx is a global regulator for response to thiol-specific oxidative stress. It interacts with RNA polymerase. MgsR (modulator of the general stress response, also called YqgZ) provides a second level of regulation for more than a third of the proteins in the B. subtilis general stress regulon controlled by Sigma-B. [Regulatory functions, DNA interactions]


Pssm-ID: 273720  Cd Length: 117  Bit Score: 46.27  E-value: 1.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491004467    5 VKIYHNPRCSKSRDTLSLLKANGIDPEVVLYLETPPDADTLRQLLKMLGmVSARELMRQKEDLYKSLELADP--QLSEEA 82
Cdd:TIGR01617   1 IKVYGSPNCTTCKKARRWLEANGIEYQFIDIGEDGPTREELLDILSLLE-DGIDPLLNTRGQSYRALNTSNTflDLSDKE 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 491004467   83 LIQAIVDNPKLMERPIVVSHGQA-RIGRPPEQVLE 116
Cdd:TIGR01617  80 ALELLAEDPALLRRPLIVDTKNRlLIGFKSESIEE 114
PRK12559 PRK12559
transcriptional regulator Spx; Provisional
 5-114 3.82e-04

transcriptional regulator Spx; Provisional


Pssm-ID: 79035  Cd Length: 131  Bit Score: 37.39  E-value: 3.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491004467   5 VKIYHNPRCSKSRDTLSLLKANGIDPEVVLYLETPPDADTLRQLLKmLGMVSARELMRQKEDLYKSLELADPQLSEEALI 84
Cdd:PRK12559   2 VVLYTTASCASCRKAKAWLEENQIDYTEKNIVSNSMTVDELKSILR-LTEEGATEIISTRSKTFQDLNINIEELSLNEFY 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 491004467  85 QAIVDNPKLMERPIVVSHGQARIGRPPEQV 114
Cdd:PRK12559  81 KLIIEHPLMLRRPIMLDEKRLQIGFNDEEI 110
spxA PRK01655
transcriptional regulator Spx; Reviewed
 5-108 1.50e-03

transcriptional regulator Spx; Reviewed


Pssm-ID: 179316  Cd Length: 131  Bit Score: 35.82  E-value: 1.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491004467   5 VKIYHNPRCSKSRDTLSLLKANGIDPEVVLYLETPPDADTLRQLLKML-----GMVSARELMRQKedlyksLELADPQLS 79
Cdd:PRK01655   2 VTLFTSPSCTSCRKAKAWLEEHDIPFTERNIFSSPLTIDEIKQILRMTedgtdEIISTRSKVFQK------LNVDVESLS 75

                         90       100
                 ....*....|....*....|....*....
gi 491004467  80 EEALIQAIVDNPKLMERPIVVSHGQARIG 108
Cdd:PRK01655  76 LQDLIKLISDNPGLLRRPIIIDEKRLQVG 104
ArsC_15kD cd03033
Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown ...
 5-118 1.71e-03

Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also encodes dinitrogenase reductase ADP-ribosyltransferase (DRAT) and dinitrogenase reductase activating glycohydrolase (DRAG). ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from glutathione via glutaredoxin, through a single catalytic cysteine.


Pssm-ID: 239331  Cd Length: 113  Bit Score: 35.33  E-value: 1.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491004467   5 VKIYHNPRCSKSRDTLSLLKANGIDPEVVLYLETPPDADTLRQLLkmlGMVSARELMRQKEDLYKSLELADPQLSEEALI 84
Cdd:cd03033    2 IIFYEKPGCANNARQKALLEAAGHEVEVRDLLTEPWTAETLRPFF---GDLPVAEWFNPAAPRVKSGEVVPEALDEEEAL 78

                         90       100       110
                 ....*....|....*....|....*....|....
gi 491004467  85 QAIVDNPKLMERPIVVSHGQARIGRPPEQVLEIV 118
Cdd:cd03033   79 ALMIADPLLIRRPLMQVGDRRMVGFDTARVDAWI 112
ArsC_Yffb cd03035
Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein ...
 5-108 2.47e-03

Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine suggest that it is likely to function as a glutathione (GSH)-dependent thiol reductase. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from GSH via glutaredoxin, through a single catalytic cysteine.


Pssm-ID: 239333  Cd Length: 105  Bit Score: 34.88  E-value: 2.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491004467   5 VKIYHNPRCSKSRDTLSLLKANGIDPEVVLYLETPPDADTLRQLLKMLG---MVSARELM-RQkedlyksleLADPQ--- 77
Cdd:cd03035    1 ITLYGIKNCDTVKKARKWLEARGVAYTFHDYRKDGLDAATLERWLAKVGwetLLNKRGTTwRK---------LDDAQkaa 71

                         90       100       110
                 ....*....|....*....|....*....|.
gi 491004467  78 LSEEALIQAIVDNPKLMERPIVVSHGQARIG 108
Cdd:cd03035   72 LDAAKAIALMLEHPSLIKRPVLETGGKVLVG 102
SK cd00464
Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic ...
 18-75 3.09e-03

Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids, p-aminobenzoic acid, folate and ubiquinone. Shikimate kinase catalyses the phosphorylation of the 3-hydroxyl group of shikimic acid using ATP.


Pssm-ID: 238260 [Multi-domain]  Cd Length: 154  Bit Score: 35.22  E-value: 3.09e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491004467  18 DTLSLLKANGIdpevVLYLETPPD-------ADTLRQLLKMLGMVSARELMRQKEDLYKslELAD 75
Cdd:cd00464   84 ENRRLLLENGI----VVWLDASPEellerlaRDKTRPLLQDEDPERLRELLEEREPLYR--EVAD 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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