NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|491002992|ref|WP_004864713|]
View 

MULTISPECIES: sensor histidine kinase [Raoultella]

Protein Classification

sensor histidine kinase( domain architecture ID 11461692)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to an external signal

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0005524|GO:0004673|GO:0007165|GO:0000155
PubMed:  10637609|10339418
SCOP:  4001957

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
322-560 6.07e-69

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


:

Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 226.29  E-value: 6.07e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992 322 VIGTIKLYEAKNRLFSSINRTLGEGIAQLLSAQILAGQYERQKALLTQSEIKLLHAQVNPHFLFNALNTLKAVIRRDSDQ 401
Cdd:COG3275  111 LLLLLLLLLLLLLLLLLLLLLILILLALLLSLQEEELELEELEKELLEAELKALKAQINPHFLFNTLNSIYSLIREDPEK 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992 402 AGQLVQYLSTFFRKNLKR-PSEFVTLADEIEHVNAYLQIEKARFQANLQIQMLVPDALAHHQLPAFTLQPIVENAIKHGT 480
Cdd:COG3275  191 ARELLLKLSDLLRYSLYEsDKELVPLEEELEFLENYLELEKLRFGDRLQVEIDIDEELLDLLIPPLLLQPLVENAIKHGI 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992 481 SQHLGVGEITIRASQHERWLQLDIEDNAGLYQDNPNA--SGLGMSLVDRRLRARFGADCGITVTCEAERFTRVTLRLPLE 558
Cdd:COG3275  271 SSKEGGGTISISIEVEGDRLVIEVENNGVGIQPKKKKkgSGIGLKNVRERLELLYGDKYSLEIESTDGGGTKVTLKIPLK 350


                 ..
gi 491002992 559 EN 560
Cdd:COG3275  351 KE 352
5TM-5TMR_LYT pfam07694
5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors ...
 27-196 3.73e-49

5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors of the LytS-YhcK type).


:

Pssm-ID: 429599  Cd Length: 170  Bit Score: 167.75  E-value: 3.73e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992   27 TRLFIPLMQ-VTVRLPHKLLCYVTFSIFCIMGTYFGLHIE-DSIANTRAIGAVMGGLLGGPVVGGLVGLTGGLHRYSLGG 104
Cdd:pfam07694   1 IPLFRRLLSkRRLRLKDKVLLGLIFGLFSILGTYTGIEIEpGAIANTRAVGIVLAGLLGGPIVGLIAGLIAGLHRYFLGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992  105 MTALSCMVSTIVEGLLGGLVHSVLVKRGRpdkVFSPLTAGAITFFAELVQMMIILLIARPFQDALHLVQSIAAPMMVTNT 184
Cdd:pfam07694  81 FTALACGISTILAGLIAGLLHRRLKRRRR---LISPLLAFLIGLIAEILQMLLILLLALPFDLALALVKTIALPMILVNS 157

                         170
                  ....*....|..
gi 491002992  185 VGAALFMRILLD 196
Cdd:pfam07694 158 LGTAIFLSILRD 169
GAF_2 pfam13185
GAF domain; The GAF domain is named after some of the proteins it is found in, including ...
 240-353 9.51e-05

GAF domain; The GAF domain is named after some of the proteins it is found in, including cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. It is also found in guanylyl cyclases and phytochromes. The structure of a GAF domain shows that the domain shares a similar fold with the PAS domain. This domain can bind O2, CO and NO (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


:

Pssm-ID: 433019 [Multi-domain]  Cd Length: 137  Bit Score: 42.45  E-value: 9.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992  240 IQELDIGAVAI----TDRDKLLAFTGIGDDH-HLPGKPISSSYTQKAIDSGEVVYADGNEVPYRCSIHP--NCKLGSTLV 312
Cdd:pfam13185  15 AVELGASAVGFillvDDDGRLAAWGGAADELsAALDDPPGEGLVGEALRTGRPVIVNDLAADPAKKGLPagHAGLRSFLS 94

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 491002992  313 IPLRGENqRVIGTIKLYEAKNRLFSSINRTLGEGIAQLLSA 353
Cdd:pfam13185  95 VPLVSGG-RVVGVLALGSNRPGAFDEEDLELLELLAEQAAI 134
 
Name Accession Description Interval E-value
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
322-560 6.07e-69

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 226.29  E-value: 6.07e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992 322 VIGTIKLYEAKNRLFSSINRTLGEGIAQLLSAQILAGQYERQKALLTQSEIKLLHAQVNPHFLFNALNTLKAVIRRDSDQ 401
Cdd:COG3275  111 LLLLLLLLLLLLLLLLLLLLLILILLALLLSLQEEELELEELEKELLEAELKALKAQINPHFLFNTLNSIYSLIREDPEK 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992 402 AGQLVQYLSTFFRKNLKR-PSEFVTLADEIEHVNAYLQIEKARFQANLQIQMLVPDALAHHQLPAFTLQPIVENAIKHGT 480
Cdd:COG3275  191 ARELLLKLSDLLRYSLYEsDKELVPLEEELEFLENYLELEKLRFGDRLQVEIDIDEELLDLLIPPLLLQPLVENAIKHGI 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992 481 SQHLGVGEITIRASQHERWLQLDIEDNAGLYQDNPNA--SGLGMSLVDRRLRARFGADCGITVTCEAERFTRVTLRLPLE 558
Cdd:COG3275  271 SSKEGGGTISISIEVEGDRLVIEVENNGVGIQPKKKKkgSGIGLKNVRERLELLYGDKYSLEIESTDGGGTKVTLKIPLK 350


                 ..
gi 491002992 559 EN 560
Cdd:COG3275  351 KE 352
5TM-5TMR_LYT pfam07694
5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors ...
 27-196 3.73e-49

5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors of the LytS-YhcK type).


Pssm-ID: 429599  Cd Length: 170  Bit Score: 167.75  E-value: 3.73e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992   27 TRLFIPLMQ-VTVRLPHKLLCYVTFSIFCIMGTYFGLHIE-DSIANTRAIGAVMGGLLGGPVVGGLVGLTGGLHRYSLGG 104
Cdd:pfam07694   1 IPLFRRLLSkRRLRLKDKVLLGLIFGLFSILGTYTGIEIEpGAIANTRAVGIVLAGLLGGPIVGLIAGLIAGLHRYFLGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992  105 MTALSCMVSTIVEGLLGGLVHSVLVKRGRpdkVFSPLTAGAITFFAELVQMMIILLIARPFQDALHLVQSIAAPMMVTNT 184
Cdd:pfam07694  81 FTALACGISTILAGLIAGLLHRRLKRRRR---LISPLLAFLIGLIAEILQMLLILLLALPFDLALALVKTIALPMILVNS 157

                         170
                  ....*....|..
gi 491002992  185 VGAALFMRILLD 196
Cdd:pfam07694 158 LGTAIFLSILRD 169
HATPase_YehU-like cd16956
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 463-556 2.78e-31

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.


Pssm-ID: 340432 [Multi-domain]  Cd Length: 101  Bit Score: 116.77  E-value: 2.78e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992 463 LPAFTLQPIVENAIKHGTSQHLGVGEITIRASQHERWLQLDIEDNAGLYQDNPNAS-------GLGMSLVDRRLRARFGA 535
Cdd:cd16956    1 LPFLTLQPIVENAVKHGLSGLLDGGRVEITARLDGQHLLLEVEDNGGGMDPDTLARilirssnGLGLNLVDKRLRQAFGN 80

                         90       100
                 ....*....|....*....|.
gi 491002992 536 DCGITVTCEAERFTRVTLRLP 556
Cdd:cd16956   81 DYGLDIECAPGEGTRITIRLP 101
His_kinase pfam06580
Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. ...
 370-444 3.24e-29

Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.


Pssm-ID: 461952 [Multi-domain]  Cd Length: 79  Bit Score: 110.22  E-value: 3.24e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491002992  370 SEIKLLHAQVNPHFLFNALNTLKAVIRRDSDQAGQLVQYLSTFFRKNLKRPSEFVTLADEIEHVNAYLQIEKARF 444
Cdd:pfam06580   1 AELKALQAQINPHFLFNTLNSISSLAIEDPEEAAEMILKLSDLLRYSLYEGEELVTLEEELEFLENYLEIQKIRF 75
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 468-558 1.37e-08

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 53.04  E-value: 1.37e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992   468 LQPIVENAIKHGTSQhlgvGEITIRASQHERWLQLDIEDN-AGL------------YQDNPNAS-----GLGMSLVDRRL 529
Cdd:smart00387  10 LSNLLDNAIKYTPEG----GRITVTLERDGDHVEITVEDNgPGIppedlekifepfFRTDKRSRkiggtGLGLSIVKKLV 85

                           90       100
                   ....*....|....*....|....*....
gi 491002992   530 RaRFGADcgITVTCEAERFTRVTLRLPLE 558
Cdd:smart00387  86 E-LHGGE--ISVESEPGGGTTFTITLPLE 111
GAF_2 pfam13185
GAF domain; The GAF domain is named after some of the proteins it is found in, including ...
 240-353 9.51e-05

GAF domain; The GAF domain is named after some of the proteins it is found in, including cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. It is also found in guanylyl cyclases and phytochromes. The structure of a GAF domain shows that the domain shares a similar fold with the PAS domain. This domain can bind O2, CO and NO (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 433019 [Multi-domain]  Cd Length: 137  Bit Score: 42.45  E-value: 9.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992  240 IQELDIGAVAI----TDRDKLLAFTGIGDDH-HLPGKPISSSYTQKAIDSGEVVYADGNEVPYRCSIHP--NCKLGSTLV 312
Cdd:pfam13185  15 AVELGASAVGFillvDDDGRLAAWGGAADELsAALDDPPGEGLVGEALRTGRPVIVNDLAADPAKKGLPagHAGLRSFLS 94

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 491002992  313 IPLRGENqRVIGTIKLYEAKNRLFSSINRTLGEGIAQLLSA 353
Cdd:pfam13185  95 VPLVSGG-RVVGVLALGSNRPGAFDEEDLELLELLAEQAAI 134
 
Name Accession Description Interval E-value
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
322-560 6.07e-69

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 226.29  E-value: 6.07e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992 322 VIGTIKLYEAKNRLFSSINRTLGEGIAQLLSAQILAGQYERQKALLTQSEIKLLHAQVNPHFLFNALNTLKAVIRRDSDQ 401
Cdd:COG3275  111 LLLLLLLLLLLLLLLLLLLLLILILLALLLSLQEEELELEELEKELLEAELKALKAQINPHFLFNTLNSIYSLIREDPEK 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992 402 AGQLVQYLSTFFRKNLKR-PSEFVTLADEIEHVNAYLQIEKARFQANLQIQMLVPDALAHHQLPAFTLQPIVENAIKHGT 480
Cdd:COG3275  191 ARELLLKLSDLLRYSLYEsDKELVPLEEELEFLENYLELEKLRFGDRLQVEIDIDEELLDLLIPPLLLQPLVENAIKHGI 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992 481 SQHLGVGEITIRASQHERWLQLDIEDNAGLYQDNPNA--SGLGMSLVDRRLRARFGADCGITVTCEAERFTRVTLRLPLE 558
Cdd:COG3275  271 SSKEGGGTISISIEVEGDRLVIEVENNGVGIQPKKKKkgSGIGLKNVRERLELLYGDKYSLEIESTDGGGTKVTLKIPLK 350


                 ..
gi 491002992 559 EN 560
Cdd:COG3275  351 KE 352
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
359-560 4.20e-58

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 200.24  E-value: 4.20e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992 359 QYERQKALLtQSEIKLLHAQVNPHFLFNALNTLKAVIRR-DSDQAGQLVQYLSTFFRKNLKRPSEFVTLADEIEHVNAYL 437
Cdd:COG2972  232 VYELELEKK-EAELKALQAQINPHFLFNTLNSIRWLAELeDPEEAEEMLEALSKLLRYSLSKGDELVTLEEELELIKSYL 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992 438 QIEKARFQANLQIQMLVPDALAHHQLPAFTLQPIVENAIKHGTSQHLGVGEITIRASQHERWLQLDIEDN-AGL------ 510
Cdd:COG2972  311 EIQKLRFGDRLEVEIEIDEELLDLLIPKLILQPLVENAIEHGIEPKEGGGTIRISIRKEGDRLVITVEDNgVGMpeekle 390

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 491002992 511 -----YQDNPNASGLGMSLVDRRLRARFGADCGITVTCEAERFTRVTLRLPLEEN 560
Cdd:COG2972  391 klleeLSSKGEGRGIGLRNVRERLKLYYGEEYGLEIESEPGEGTTVTIRIPLEEE 445
5TM-5TMR_LYT pfam07694
5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors ...
 27-196 3.73e-49

5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors of the LytS-YhcK type).


Pssm-ID: 429599  Cd Length: 170  Bit Score: 167.75  E-value: 3.73e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992   27 TRLFIPLMQ-VTVRLPHKLLCYVTFSIFCIMGTYFGLHIE-DSIANTRAIGAVMGGLLGGPVVGGLVGLTGGLHRYSLGG 104
Cdd:pfam07694   1 IPLFRRLLSkRRLRLKDKVLLGLIFGLFSILGTYTGIEIEpGAIANTRAVGIVLAGLLGGPIVGLIAGLIAGLHRYFLGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992  105 MTALSCMVSTIVEGLLGGLVHSVLVKRGRpdkVFSPLTAGAITFFAELVQMMIILLIARPFQDALHLVQSIAAPMMVTNT 184
Cdd:pfam07694  81 FTALACGISTILAGLIAGLLHRRLKRRRR---LISPLLAFLIGLIAEILQMLLILLLALPFDLALALVKTIALPMILVNS 157

                         170
                  ....*....|..
gi 491002992  185 VGAALFMRILLD 196
Cdd:pfam07694 158 LGTAIFLSILRD 169
HATPase_YehU-like cd16956
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 463-556 2.78e-31

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.


Pssm-ID: 340432 [Multi-domain]  Cd Length: 101  Bit Score: 116.77  E-value: 2.78e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992 463 LPAFTLQPIVENAIKHGTSQHLGVGEITIRASQHERWLQLDIEDNAGLYQDNPNAS-------GLGMSLVDRRLRARFGA 535
Cdd:cd16956    1 LPFLTLQPIVENAVKHGLSGLLDGGRVEITARLDGQHLLLEVEDNGGGMDPDTLARilirssnGLGLNLVDKRLRQAFGN 80

                         90       100
                 ....*....|....*....|.
gi 491002992 536 DCGITVTCEAERFTRVTLRLP 556
Cdd:cd16956   81 DYGLDIECAPGEGTRITIRLP 101
His_kinase pfam06580
Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. ...
 370-444 3.24e-29

Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.


Pssm-ID: 461952 [Multi-domain]  Cd Length: 79  Bit Score: 110.22  E-value: 3.24e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491002992  370 SEIKLLHAQVNPHFLFNALNTLKAVIRRDSDQAGQLVQYLSTFFRKNLKRPSEFVTLADEIEHVNAYLQIEKARF 444
Cdd:pfam06580   1 AELKALQAQINPHFLFNTLNSISSLAIEDPEEAAEMILKLSDLLRYSLYEGEELVTLEEELEFLENYLEIQKIRF 75
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 463-556 1.93e-24

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 97.90  E-value: 1.93e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992 463 LPAFTLQPIVENAIKHGTSQHLGVGEITIRASQHERWLQLDIEDNAGLYQ--------DNPN-ASGLGMSLVDRRLRARF 533
Cdd:cd16924    1 IPPFTLQPLVENAIQHGLSPLTDKGVVTISALKEDNHVMIEVEDNGRGIDpkvlnilgKKPKeGNGIGLYNVHQRLILLF 80

                         90       100
                 ....*....|....*....|...
gi 491002992 534 GADCGITVTCEAERFTRVTLRLP 556
Cdd:cd16924   81 GEDYGIHIASEPDKGTRITFTIP 103
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
393-558 2.60e-09

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 58.77  E-value: 2.60e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992 393 AVIRRDSDQAGQLVQYLSTFFR---KNLKRPSEFVTLADEIEHVNAYLQiEKARfQANLQIQMLVPDALAHHQLPAFTLQ 469
Cdd:COG0642  148 ETILRSADRLLRLINDLLDLSRleaGKLELEPEPVDLAELLEEVVELFR-PLAE-EKGIELELDLPDDLPTVRGDPDRLR 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992 470 PI----VENAIKHGTSQhlgvGEITIRASQHERWLQLDIEDN-AGL------------YQ----DNPNASGLGMSLVdRR 528
Cdd:COG0642  226 QVllnlLSNAIKYTPEG----GTVTVSVRREGDRVRISVEDTgPGIppedlerifepfFRtdpsRRGGGTGLGLAIV-KR 300

                        170       180       190
                 ....*....|....*....|....*....|
gi 491002992 529 LRARFGADcgITVTCEAERFTRVTLRLPLE 558
Cdd:COG0642  301 IVELHGGT--IEVESEPGKGTTFTVTLPLA 328
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 468-558 1.37e-08

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 53.04  E-value: 1.37e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992   468 LQPIVENAIKHGTSQhlgvGEITIRASQHERWLQLDIEDN-AGL------------YQDNPNAS-----GLGMSLVDRRL 529
Cdd:smart00387  10 LSNLLDNAIKYTPEG----GRITVTLERDGDHVEITVEDNgPGIppedlekifepfFRTDKRSRkiggtGLGLSIVKKLV 85

                           90       100
                   ....*....|....*....|....*....
gi 491002992   530 RaRFGADcgITVTCEAERFTRVTLRLPLE 558
Cdd:smart00387  86 E-LHGGE--ISVESEPGGGTTFTITLPLE 111
HATPase_YpdA-like cd16955
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 463-545 2.09e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340431 [Multi-domain]  Cd Length: 102  Bit Score: 52.08  E-value: 2.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992 463 LPAFTLQPIVENAIKHGTSQHLGVGEITIRAS-QHERWLQLDIEDNA---------GLYQDNPNASGLGMSLVDRRLRAR 532
Cdd:cd16955    1 IPKLMIQPLVENAIVHGIQEKKGKGVVKISVKkQLKNRLHIAVEDNGigispkvieRVEQDEMPGNKIGLLNVHQRLKLG 80

                         90
                 ....*....|...
gi 491002992 533 FGADCGITVTCEA 545
Cdd:cd16955   81 YGEGLHIRSRPDP 93
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 468-559 1.06e-07

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 50.44  E-value: 1.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992  468 LQPIVENAIKHGTSQhlgvGEITIRASQHErWLQLDIEDN-------------AGLYQDNPNA---SGLGMSLVdRRLRA 531
Cdd:pfam02518  10 LSNLLDNALKHAAKA----GEITVTLSEGG-ELTLTVEDNgigippedlprifEPFSTADKRGgggTGLGLSIV-RKLVE 83

                          90       100
                  ....*....|....*....|....*...
gi 491002992  532 RFGADcgITVTCEAERFTRVTLRLPLEE 559
Cdd:pfam02518  84 LLGGT--ITVESEPGGGTTVTLTLPLAQ 109
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 472-559 1.47e-06

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 51.06  E-value: 1.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992 472 VENAIKHGTSQHLGvGEITIRASQHERWLQLDIEDN-AGL--YQDNPNASGLGMSLVdRRLRARFGAdcgiTVTCEAERF 548
Cdd:COG3920  408 VTNALKHAFLSGEG-GRIRVSWRREDGRLRLTVSDNgVGLpeDVDPPARKGLGLRLI-RALVRQLGG----TLELDRPEG 481

                         90
                 ....*....|.
gi 491002992 549 TRVTLRLPLEE 559
Cdd:COG3920  482 TRVRITFPLAE 492
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
395-560 2.35e-06

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 49.13  E-value: 2.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992 395 IRRDSDQAGQLVQYLSTFFR---KNLKRPSEFVTLADEIEHVnaylqIEKARFQA---NLQIQMLVPDALAHHQLPAFTL 468
Cdd:COG2205   59 IRESAERLLRLIEDLLDLSRlesGKLSLELEPVDLAELLEEA-----VEELRPLAeekGIRLELDLPPELPLVYADPELL 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992 469 QPIV----ENAIKHGTSQhlgvGEITIRASQHERWLQLDIEDN-AGL------------YQDNPNA----SGLGMSLVdR 527
Cdd:COG2205  134 EQVLanllDNAIKYSPPG----GTITISARREGDGVRISVSDNgPGIpeeeleriferfYRGDNSRgeggTGLGLAIV-K 208

                        170       180       190
                 ....*....|....*....|....*....|...
gi 491002992 528 RLRARFGADcgITVTCEAERFTRVTLRLPLEEN 560
Cdd:COG2205  209 RIVEAHGGT--IWVESEPGGGTTFTVTLPLAES 239
HATPase_EL346-LOV-HK-like cd16951
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 471-556 8.18e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.


Pssm-ID: 340427 [Multi-domain]  Cd Length: 131  Bit Score: 45.49  E-value: 8.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992 471 IVENAIKHGTSQHLGvGEITIRASQHERWLQLDIEDNA-GLYQD--NPNASGLGMSLVDRRLRARFGADCGITvtcEAER 547
Cdd:cd16951   47 LLQNALKHAFSDREG-GTITIRSVVDGDYLRITVIDDGvGLPQDedWPNKGSLGLQIVRSLVEGELKAFLEVQ---SAEN 122


                 ....*....
gi 491002992 548 FTRVTLRLP 556
Cdd:cd16951  123 GTRVNIDIP 131
HATPase_LytS-like cd16957
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 463-556 1.35e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.


Pssm-ID: 340433 [Multi-domain]  Cd Length: 106  Bit Score: 44.34  E-value: 1.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992 463 LPAFTLQPIVENAIKHGTSQHLGVGEITIRASQHERWLQLDIEDNA-GLYQDN---------PNASGLGMSLVD--RRLR 530
Cdd:cd16957    1 VPPFALQVLVENAIRHAFPKRKENNEVRVVVKKDQHKVHVSVSDNGqGIPEERldllgkttvTSEKGTGTALENlnRRLI 80

                         90       100
                 ....*....|....*....|....*.
gi 491002992 531 ARFGADCGITVTCEAERFTRVTLRLP 556
Cdd:cd16957   81 GLFGSEACLHIESEVHGGTEVWFVIP 106
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
393-560 3.07e-05

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 46.47  E-value: 3.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992 393 AVIRRDSDQAGQLVQ---YLSTFFRKNLKRPSEFVTLADEIEHVNAYLQIEKARFQANLQIQMLVPDALAH------HQL 463
Cdd:COG5002  206 EIILEEAERLSRLVNdllDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPLLVLgdpdrlEQV 285

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992 464 paftLQPIVENAIKHGTSQhlgvGEITIRASQHERWLQLDIEDN-AGL------------YQ-DNPNA-----SGLGMSL 524
Cdd:COG5002  286 ----LTNLLDNAIKYTPEG----GTITVSLREEDDQVRISVRDTgIGIpeedlpriferfYRvDKSRSretggTGLGLAI 357

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 491002992 525 VdRRLRARFGADcgITVTCEAERFTRVTLRLPLEEN 560
Cdd:COG5002  358 V-KHIVEAHGGR--IWVESEPGKGTTFTITLPLARE 390
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 471-560 3.15e-05

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 46.38  E-value: 3.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992 471 IVENAIKHGTSQHLGVGEITIRASQHERWLQLDIEDN--------------AGLYQDNPNASGLGMSLVDRRLRARFGAd 536
Cdd:COG3290  289 LLDNAIEAVEKLPEEERRVELSIRDDGDELVIEVEDSgpgipeellekifeRGFSTKLGEGRGLGLALVKQIVEKYGGT- 367

                         90       100
                 ....*....|....*....|....
gi 491002992 537 cgITVTCEAERFTRVTLRLPLEEN 560
Cdd:COG3290  368 --IEVESEEGEGTVFTVRLPKEGE 389
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
474-559 6.54e-05

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 44.61  E-value: 6.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992 474 NAIKHGtsqhlGVGEITIRASQHERWLQLDIEDN-AGLYQDNPNASGLGMSLVDRRLRArFGADCgiTVTCEAERFTRVT 552
Cdd:COG4585  173 NALKHA-----GATRVTVTLEVDDGELTLTVRDDgVGFDPEAAPGGGLGLRGMRERAEA-LGGTL--TIGSAPGGGTRVR 244


                 ....*..
gi 491002992 553 LRLPLEE 559
Cdd:COG4585  245 ATLPLAA 251
GAF_2 pfam13185
GAF domain; The GAF domain is named after some of the proteins it is found in, including ...
 240-353 9.51e-05

GAF domain; The GAF domain is named after some of the proteins it is found in, including cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. It is also found in guanylyl cyclases and phytochromes. The structure of a GAF domain shows that the domain shares a similar fold with the PAS domain. This domain can bind O2, CO and NO (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 433019 [Multi-domain]  Cd Length: 137  Bit Score: 42.45  E-value: 9.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992  240 IQELDIGAVAI----TDRDKLLAFTGIGDDH-HLPGKPISSSYTQKAIDSGEVVYADGNEVPYRCSIHP--NCKLGSTLV 312
Cdd:pfam13185  15 AVELGASAVGFillvDDDGRLAAWGGAADELsAALDDPPGEGLVGEALRTGRPVIVNDLAADPAKKGLPagHAGLRSFLS 94

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 491002992  313 IPLRGENqRVIGTIKLYEAKNRLFSSINRTLGEGIAQLLSA 353
Cdd:pfam13185  95 VPLVSGG-RVVGVLALGSNRPGAFDEEDLELLELLAEQAAI 134
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 474-556 4.48e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 39.46  E-value: 4.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992 474 NAIKHGtsqhlGVGEITIRASQHERWLQLDIEDNAGLYQDNPNASGLGMSLVDRRLRAR-FGADCgiTVTCEAERFTRVT 552
Cdd:cd16917   11 NALKHA-----GASRVRVTLSYTADELTLTVVDDGVGFDGPAPPGGGGFGLLGMRERAElLGGTL--TIGSRPGGGTRVT 83


                 ....
gi 491002992 553 LRLP 556
Cdd:cd16917   84 ARLP 87
GAF_3 pfam13492
GAF domain;
243-355 6.94e-04

GAF domain;


Pssm-ID: 433253 [Multi-domain]  Cd Length: 129  Bit Score: 40.05  E-value: 6.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992  243 LDIGAVAITDRDKLLAFTGIGDDHHLPGK---PISSSYTQKAIDSGEVVYADGNEVpyrcsiHPNCKLGSTLVIPLRGEN 319
Cdd:pfam13492  19 AERAAVYLLDEDGNKLQVAAGYDGEPDPSeslDADSPLARRALSSGEPISGLGSAG------EDGLPDGPALVVPLVAGR 92

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 491002992  320 QrVIGTIKLYEAKNRLFSSINRTLGEGIAQLLSAQI 355
Cdd:pfam13492  93 R-VIGVLALASSKPRAFDAEDLRLLESLAAQIATAI 127
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 393-561 7.72e-04

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 42.26  E-value: 7.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992 393 AVIRRDSDQAGQLVQYLSTFFR--KNLKRPSEFVTLADE-IEHVNAYLQIEKARFQANLQIQMLV----PDALahHQLpa 465
Cdd:COG5000  246 DTIIRQVDRLKRIVDEFLDFARlpEPQLEPVDLNELLREvLALYEPALKEKDIRLELDLDPDLPEvladRDQL--EQV-- 321

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992 466 ftLQPIVENAIKHGTSQhlgvGEITIRASQHERWLQLDIEDN-AGLYQDN------------PNASGLGMSLVdRRLRAR 532
Cdd:COG5000  322 --LINLLKNAIEAIEEG----GEIEVSTRREDGRVRIEVSDNgPGIPEEVlerifepffttkPKGTGLGLAIV-KKIVEE 394

                        170       180
                 ....*....|....*....|....*....
gi 491002992 533 FGADcgITVTCEAERFTRVTLRLPLEENA 561
Cdd:COG5000  395 HGGT--IELESRPGGGTTFTIRLPLAEEA 421
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 373-557 1.72e-03

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 40.94  E-value: 1.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992 373 KLLHAQVNPHFLFNALNTlkavIRRDSDQAGQLVQYLSTFFRKNLKRPSEfVTLADEIEHVnayLQIEKARF-QANLQIQ 451
Cdd:COG4191  169 RRLEDEPDPEELREALER----ILEGAERAAEIVRSLRAFSRRDEEEREP-VDLNELIDEA---LELLRPRLkARGIEVE 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992 452 MLVPDalahhQLPAFTLQP---------IVENAIkHGTSQHLGvGEITIRASQHERWLQLDIEDN-AGLYQDN------P 515
Cdd:COG4191  241 LDLPP-----DLPPVLGDPgqleqvllnLLINAI-DAMEEGEG-GRITISTRREGDYVVISVRDNgPGIPPEVlerifeP 313

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 491002992 516 --------NASGLGMSLVdRRLRARFGADcgITVTCEAERFTRVTLRLPL 557
Cdd:COG4191  314 ffttkpvgKGTGLGLSIS-YGIVEKHGGR--IEVESEPGGGTTFTITLPL 360
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
394-561 4.58e-03

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 39.44  E-value: 4.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992 394 VIRRDSDQAGQLVQYLSTFFRKnlkRPSEF--VTLADEIEHVnayLQIEKARFQANLQIQML----VPDALAH----HQL 463
Cdd:COG3852  175 LIIEEADRLNNLVDRLLSFSRP---RPPERepVNLHEVLERV---LELLRAEAPKNIRIVRDydpsLPEVLGDpdqlIQV 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491002992 464 paftLQPIVENAIKHGTSQhlgvGEITIRAS----------QHERWLQLDIEDN-AGLYQDN------------PNASGL 520
Cdd:COG3852  249 ----LLNLVRNAAEAMPEG----GTITIRTRverqvtlgglRPRLYVRIEVIDNgPGIPEEIldrifepffttkEKGTGL 320

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 491002992 521 GMSLVdRRLRARFGADcgITVTCEAERFTRVTLRLPLEENA 561
Cdd:COG3852  321 GLAIV-QKIVEQHGGT--IEVESEPGKGTTFRIYLPLEQAE 358
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH